pre-miRNA Information
pre-miRNA hsa-mir-23a   
Genomic Coordinates chr19: 13836587 - 13836659
Synonyms MIRN23A, hsa-mir-23a, miRNA23A, MIR23A
Description Homo sapiens miR-23a stem-loop
Comment This miRNA was previously named miR-23 . This finding was later retracted after the discovery that the regulated gene was human homolog of ES1 (HES1), whose function is unknown.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-23a-5p
Sequence 9| GGGGUUCCUGGGGAUGGGAUUU |30
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs748509260 12 dbSNP
rs1205403719 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GDE1   
Synonyms 363E6.2, MIR16
Description glycerophosphodiester phosphodiesterase 1
Transcript NM_016641   
Expression
Putative miRNA Targets on GDE1
3'UTR of GDE1
(miRNA target sites are highlighted)
>GDE1|NM_016641|3'UTR
   1 ACTTTCACGGTGGGACGAAACGGGTTCAGAAACTGCCAGGGGCCTCATACAGGGATATCAAAATACCCTTTGTGCTAGCC
  81 CAGGCCCTGGGGAATCAGGTGACTCACACAAATGCAATAGTTGGTCACTGCATTTTTACCTGAACCAAAGCTAAACCCGG
 161 TGTTGCCACCATGCACCATGGCATGCCAGAGTTCAACACTGTTGCTCTTGAAAATCTGGGTCTGAAAAAACGCACAAGAG
 241 CCCCTGCCCTGCCCTAGCTGAGGCACACAGGGAGACCCAGTGAGGATAAGCACAGATTGAATTGTACAGTTTGCAGATGC
 321 AGATGTAAATGCATGGGACATGCATGATAACTCAGAGTTGACATTTTAAAACTTGCCACACTTATTTCAAATATTTGTAC
 401 TCAGCTATGTTAACATGTACTGTAGACATCAAACTTGTGGCCATACTAATAAAATTATTAAAAGGAGCACTAAAGGAAAA
 481 CTGTGTGCCAAGCATCATATCCTAAGGCATACGGAATTTGGGGAAGCCACCATGCAATCCAGTGAGGCTTCAGTGTACAG
 561 CAACCAAAATGGTAGGGAGGTCTTGAAGCCAATGAGGGATTTATAGCATCTTGAATAGAGAGCTGCAAACCACCAGGGGG
 641 CAGAGTTGCATTTTTCCAGGCTTTTTAGGAAGCTCTGCAACAGATGTGATCTGATCATAGGCAATTAGAACTGGAAGAAA
 721 CTTCCAAAAATATCTAGGTTTGTCCTCATTTTACAAATGAGGAAACTAAACTCTGTGGAAGGGAAGGGGTTGCCTCAAAA
 801 GTCACAGCTTAGCTGGGCACAGTGGCTCATGCCGATAATCCCAGCAATTCAGAAAGCTGAGGCAGGAGGATTACTTGAGG
 881 CCAGACTGGGCAATATAGCAAGACCCCATCTCTAAAAAATTAGGCATGGTGGTGCATGCCTGTATTCCCAGCTACTCAGG
 961 AGGTTGAGGTGGGAGGATCACTTGAGCCCAGAAGTTCAAGGCTGCAATGAGCCATGATTACACCACGGCACTACAACCTT
1041 GGTGGCACAGTGAGAACCTGACTCTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGATAACTAGAACTTCTAGAACATCT
1121 TGTTTACAGTTAGCCAGAAACTATACAAGTGGTTTAACATGCATTATCTTACTCAATCCATACAAAAGTCTTATGGAGGT
1201 GTTAGCACTCTTTCTACTGATGAAGAACTGAGGTACTTCATAAAACCACTTACCCAAGGTGTCTTGAGTCTGGTACAACT
1281 GGCATTCAAATCTAGGTCAGTCTGCCCCCAGAGCCACTACCCTTACCCCTCACTGAATCTGCCTTTATATTGTTGAGCCC
1361 ATGACCCCAAACTGCTCTTTCCAATTTGAACTTCCAGGGATTTTATTGTGAACTTACATAGCAACATTAAAATGAAGTTG
1441 AATTGTTTTTAATGGCAACGCCGTCTGTCTCCTCTAGCTTACCGCTTCTCACCTTTCAACCCCATCTGTGGCCTTTGTCC
1521 AGGCCCACAGCTTAGCCATGGCTTCCCTCCTGCATCCCTGCCGTGGGTTGCTGGCCTCACACTTGCAGCAGCTGGACAGT
1601 GATTTTAGAAGGCCACCAGTCCCCATAGCTATGTGACAATGAGAAGCAAACTTTTTTGTGACAGATTGTATTGGCATAGG
1681 CATGATAGATGGGGATTGGTACGTTTTGAATCAGCATTTGCAAAAAAATTGTCTTGAATTTTAAAATAAACAACAAAGAT
1761 TTGTTCATTGAGTGCAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uuUAGGGUAGGGG--UCCUUGGgg 5'
            | ||||  |||  :||||:|  
Target 5' ctAGCCCAGGCCCTGGGGAATCag 3'
75 - 98 126.00 -22.50
2
miRNA  3' uuuaggGUAGGGGUCCU-UGGGg 5'
                || | | :||| |||| 
Target 5' ctgaggCA-CACAGGGAGACCCa 3'
258 - 279 115.00 -14.20
3
miRNA  3' uuuAGGGU---AGGGGUCCUUGGGg 5'
             |:|||   |::::||||| |: 
Target 5' tttTTCCAGGCTTTTTAGGAAGCTc 3'
651 - 675 115.00 -16.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31585155 17 COSMIC
COSN31598050 21 COSMIC
COSN30577852 59 COSMIC
COSN30494902 65 COSMIC
COSN30447875 68 COSMIC
COSN31602377 79 COSMIC
COSN30103175 81 COSMIC
COSN30454977 92 COSMIC
COSN31508981 125 COSMIC
COSN8230199 126 COSMIC
COSN30577714 144 COSMIC
COSN31602539 188 COSMIC
COSN23641719 488 COSMIC
COSN23191467 1050 COSMIC
COSN6081170 1182 COSMIC
COSN32150645 1219 COSMIC
COSN8391077 1245 COSMIC
COSN24952865 1453 COSMIC
COSN21516386 1768 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs747575581 5 dbSNP
rs770737790 5 dbSNP
rs1341784379 7 dbSNP
rs201160961 8 dbSNP
rs757947752 9 dbSNP
rs1325676021 11 dbSNP
rs778448691 14 dbSNP
rs562476032 16 dbSNP
rs1044644814 17 dbSNP
rs372112650 19 dbSNP
rs1412238952 21 dbSNP
rs764064115 22 dbSNP
rs756105412 31 dbSNP
rs202202853 35 dbSNP
rs766545567 36 dbSNP
rs762964578 40 dbSNP
rs1167532071 42 dbSNP
rs930997096 44 dbSNP
rs773445992 48 dbSNP
rs1257398108 50 dbSNP
rs765383538 51 dbSNP
rs972523456 54 dbSNP
rs1041582880 60 dbSNP
rs574197701 61 dbSNP
rs1011452499 66 dbSNP
rs943852302 67 dbSNP
rs1157531849 72 dbSNP
rs555491834 76 dbSNP
rs534239283 77 dbSNP
rs985291658 78 dbSNP
rs953958930 79 dbSNP
rs184843372 83 dbSNP
rs1403983999 84 dbSNP
rs1433148309 91 dbSNP
rs1261759104 93 dbSNP
rs1279809884 97 dbSNP
rs1056070256 106 dbSNP
rs1221914962 108 dbSNP
rs1283465668 109 dbSNP
rs558011192 117 dbSNP
rs1021579793 124 dbSNP
rs937095927 126 dbSNP
rs1484653298 137 dbSNP
rs1294074606 145 dbSNP
rs1284867535 150 dbSNP
rs1198389541 153 dbSNP
rs773525301 158 dbSNP
rs539484386 159 dbSNP
rs1175916839 160 dbSNP
rs1380163294 172 dbSNP
rs990515336 175 dbSNP
rs1349752694 177 dbSNP
rs1045496121 180 dbSNP
rs956071572 187 dbSNP
rs772292696 189 dbSNP
rs192796293 190 dbSNP
rs1428180596 201 dbSNP
rs550842789 203 dbSNP
rs535898301 204 dbSNP
rs1355979802 214 dbSNP
rs1232389537 231 dbSNP
rs186701458 231 dbSNP
rs564469686 232 dbSNP
rs1248123489 233 dbSNP
rs1002975674 242 dbSNP
rs1357345872 245 dbSNP
rs1384001322 254 dbSNP
rs1338598485 255 dbSNP
rs549164343 260 dbSNP
rs1273970843 266 dbSNP
rs1435617049 268 dbSNP
rs1202806733 271 dbSNP
rs1237985670 272 dbSNP
rs1023125522 282 dbSNP
rs1445659391 286 dbSNP
rs1013124594 297 dbSNP
rs887987465 298 dbSNP
rs774783879 301 dbSNP
rs7135 309 dbSNP
rs1383983368 310 dbSNP
rs146678235 324 dbSNP
rs920077977 334 dbSNP
rs976009112 340 dbSNP
rs896837329 344 dbSNP
rs1465931655 346 dbSNP
rs758729768 355 dbSNP
rs570056516 358 dbSNP
rs1454422331 375 dbSNP
rs1020088710 379 dbSNP
rs374313286 382 dbSNP
rs1037130376 389 dbSNP
rs1008320913 392 dbSNP
rs943778174 407 dbSNP
rs779919317 408 dbSNP
rs967313338 409 dbSNP
rs1341686234 414 dbSNP
rs1426202965 422 dbSNP
rs1261896788 426 dbSNP
rs183920599 428 dbSNP
rs1257720137 430 dbSNP
rs1188179753 440 dbSNP
rs76065554 441 dbSNP
rs1011442784 452 dbSNP
rs1053138 467 dbSNP
rs893085977 483 dbSNP
rs543974197 484 dbSNP
rs573647601 485 dbSNP
rs561967642 488 dbSNP
rs1169492284 492 dbSNP
rs540454479 494 dbSNP
rs914436684 496 dbSNP
rs990095650 512 dbSNP
rs1173997657 513 dbSNP
rs1401348213 515 dbSNP
rs1382740428 518 dbSNP
rs1320251705 531 dbSNP
rs956209393 535 dbSNP
rs760470244 536 dbSNP
rs1225216074 542 dbSNP
rs1277798802 545 dbSNP
rs1324536569 548 dbSNP
rs924616404 554 dbSNP
rs1254655945 555 dbSNP
rs1277683121 563 dbSNP
rs981468136 571 dbSNP
rs971463332 576 dbSNP
rs1206209525 579 dbSNP
rs1357620320 585 dbSNP
rs1444768072 590 dbSNP
rs1332533903 592 dbSNP
rs1045850684 593 dbSNP
rs1023058493 594 dbSNP
rs745819260 606 dbSNP
rs1397735482 613 dbSNP
rs1048787490 615 dbSNP
rs1464554085 626 dbSNP
rs1454162159 629 dbSNP
rs1160210319 637 dbSNP
rs1422232781 641 dbSNP
rs1382780528 649 dbSNP
rs2521795 651 dbSNP
rs1475949975 657 dbSNP
rs1028299613 669 dbSNP
rs756817784 675 dbSNP
rs975703923 676 dbSNP
rs1299524066 677 dbSNP
rs1330865761 682 dbSNP
rs993747934 684 dbSNP
rs1352160846 685 dbSNP
rs964527165 689 dbSNP
rs898102539 692 dbSNP
rs912734301 697 dbSNP
rs1438163337 700 dbSNP
rs987288924 708 dbSNP
rs1490708726 710 dbSNP
rs1036650974 714 dbSNP
rs1219768860 715 dbSNP
rs1007890432 716 dbSNP
rs890834144 732 dbSNP
rs1020231062 733 dbSNP
rs1193965467 735 dbSNP
rs1183723337 736 dbSNP
rs567896122 747 dbSNP
rs990135409 756 dbSNP
rs1257443765 760 dbSNP
rs999618385 764 dbSNP
rs371782878 774 dbSNP
rs1282634082 775 dbSNP
rs1291990905 775 dbSNP
rs1390375704 778 dbSNP
rs575555435 781 dbSNP
rs1336692001 782 dbSNP
rs1375266975 785 dbSNP
rs1316409811 789 dbSNP
rs1360959583 802 dbSNP
rs1218825715 803 dbSNP
rs914427925 816 dbSNP
rs1480760064 821 dbSNP
rs1054718345 825 dbSNP
rs191486957 830 dbSNP
rs1024175320 833 dbSNP
rs542703368 834 dbSNP
rs1184109284 836 dbSNP
rs1325914025 839 dbSNP
rs1446521009 848 dbSNP
rs368324124 865 dbSNP
rs1411069351 871 dbSNP
rs1162249407 877 dbSNP
rs1462709732 884 dbSNP
rs3179016 897 dbSNP
rs1048860529 908 dbSNP
rs930267944 919 dbSNP
rs1365276670 920 dbSNP
rs1385620252 927 dbSNP
rs971396340 931 dbSNP
rs915969419 932 dbSNP
rs900174176 938 dbSNP
rs1229122902 940 dbSNP
rs1040322023 942 dbSNP
rs1215551080 943 dbSNP
rs758070615 945 dbSNP
rs3179017 954 dbSNP
rs952252653 957 dbSNP
rs3179018 958 dbSNP
rs946118632 959 dbSNP
rs143264388 961 dbSNP
rs374108871 962 dbSNP
rs1421842604 967 dbSNP
rs565644523 969 dbSNP
rs1019159815 970 dbSNP
rs1177613300 976 dbSNP
rs553479416 981 dbSNP
rs957560186 986 dbSNP
rs534009195 989 dbSNP
rs766771810 996 dbSNP
rs11551688 1001 dbSNP
rs1302814530 1004 dbSNP
rs890802496 1007 dbSNP
rs1049444049 1010 dbSNP
rs187785060 1019 dbSNP
rs996588418 1024 dbSNP
rs551433202 1026 dbSNP
rs1156533654 1027 dbSNP
rs1438840350 1038 dbSNP
rs1223836782 1042 dbSNP
rs1395515219 1049 dbSNP
rs1264794877 1050 dbSNP
rs1054287350 1052 dbSNP
rs1195387346 1063 dbSNP
rs1310329929 1064 dbSNP
rs866008778 1064 dbSNP
rs3179019 1067 dbSNP
rs980417669 1070 dbSNP
rs1486232516 1071 dbSNP
rs934528271 1077 dbSNP
rs1477016027 1083 dbSNP
rs1245002418 1087 dbSNP
rs1198264433 1088 dbSNP
rs1447730175 1089 dbSNP
rs1288419869 1093 dbSNP
rs1214792526 1094 dbSNP
rs1353409168 1095 dbSNP
rs1175964010 1096 dbSNP
rs1200545439 1096 dbSNP
rs1218495782 1096 dbSNP
rs1218815977 1096 dbSNP
rs1223472099 1096 dbSNP
rs1284008180 1096 dbSNP
rs1295828282 1096 dbSNP
rs1307540387 1096 dbSNP
rs1318669956 1096 dbSNP
rs1339391418 1096 dbSNP
rs1346382255 1096 dbSNP
rs1365207635 1096 dbSNP
rs1405214970 1096 dbSNP
rs1413172899 1096 dbSNP
rs1427657080 1096 dbSNP
rs1454836025 1096 dbSNP
rs1479124664 1096 dbSNP
rs59519757 1096 dbSNP
rs1248736495 1098 dbSNP
rs1281534309 1098 dbSNP
rs1477243615 1098 dbSNP
rs1237083701 1101 dbSNP
rs148514696 1101 dbSNP
rs971367540 1103 dbSNP
rs924488676 1106 dbSNP
rs1273664187 1121 dbSNP
rs1442111930 1125 dbSNP
rs1045692231 1129 dbSNP
rs556721350 1143 dbSNP
rs1327745049 1152 dbSNP
rs915897293 1154 dbSNP
rs991517652 1159 dbSNP
rs3180351 1163 dbSNP
rs930738800 1176 dbSNP
rs920718366 1182 dbSNP
rs533205972 1198 dbSNP
rs1027374306 1219 dbSNP
rs972221566 1224 dbSNP
rs1279942453 1228 dbSNP
rs1375386697 1228 dbSNP
rs1237828029 1229 dbSNP
rs994592090 1248 dbSNP
rs1353065124 1249 dbSNP
rs148644736 1258 dbSNP
rs550523796 1264 dbSNP
rs1450102486 1266 dbSNP
rs1221234489 1267 dbSNP
rs1233849144 1274 dbSNP
rs987700158 1276 dbSNP
rs1412630380 1295 dbSNP
rs1177292690 1296 dbSNP
rs1380294261 1297 dbSNP
rs1444641073 1301 dbSNP
rs942935162 1302 dbSNP
rs1404425928 1310 dbSNP
rs891403306 1312 dbSNP
rs1187106021 1315 dbSNP
rs953651972 1317 dbSNP
rs1027932187 1321 dbSNP
rs1402167924 1327 dbSNP
rs1051307720 1333 dbSNP
rs946182368 1339 dbSNP
rs1383448001 1342 dbSNP
rs996950107 1346 dbSNP
rs913403632 1359 dbSNP
rs144020066 1361 dbSNP
rs1191727897 1365 dbSNP
rs1274041765 1367 dbSNP
rs1320434439 1368 dbSNP
rs370395981 1370 dbSNP
rs561481932 1374 dbSNP
rs1462172154 1392 dbSNP
rs1188968488 1396 dbSNP
rs149921525 1399 dbSNP
rs1472204716 1422 dbSNP
rs998671930 1425 dbSNP
rs183890769 1428 dbSNP
rs1168120036 1434 dbSNP
rs927272095 1454 dbSNP
rs2856615 1459 dbSNP
rs771327832 1460 dbSNP
rs564295381 1462 dbSNP
rs367803566 1463 dbSNP
rs575857848 1472 dbSNP
rs193031971 1476 dbSNP
rs1275796056 1483 dbSNP
rs577484272 1484 dbSNP
rs1027529122 1485 dbSNP
rs930643653 1493 dbSNP
rs574867373 1501 dbSNP
rs45457396 1503 dbSNP
rs1217129606 1505 dbSNP
rs1257856463 1508 dbSNP
rs1324761542 1509 dbSNP
rs1202676592 1511 dbSNP
rs1277188831 1516 dbSNP
rs964523268 1519 dbSNP
rs1193285925 1520 dbSNP
rs557743284 1522 dbSNP
rs1017672226 1528 dbSNP
rs553544849 1531 dbSNP
rs1008542731 1536 dbSNP
rs890123513 1543 dbSNP
rs1170730176 1551 dbSNP
rs1401494692 1554 dbSNP
rs114006199 1562 dbSNP
rs188542040 1563 dbSNP
rs1362648396 1570 dbSNP
rs1398345239 1571 dbSNP
rs891955351 1574 dbSNP
rs1054579923 1586 dbSNP
rs1411630637 1623 dbSNP
rs10572 1625 dbSNP
rs912041234 1633 dbSNP
rs1273520496 1635 dbSNP
rs1344944305 1639 dbSNP
rs987626669 1651 dbSNP
rs927377234 1659 dbSNP
rs1287585940 1666 dbSNP
rs1487045828 1675 dbSNP
rs1215414414 1683 dbSNP
rs1269230322 1686 dbSNP
rs183273232 1687 dbSNP
rs569162447 1694 dbSNP
rs1196495453 1699 dbSNP
rs550586177 1702 dbSNP
rs528897579 1703 dbSNP
rs567717515 1710 dbSNP
rs1418839788 1715 dbSNP
rs745636834 1719 dbSNP
rs950046634 1721 dbSNP
rs1297812982 1728 dbSNP
rs917258053 1729 dbSNP
rs1388832529 1754 dbSNP
rs1237303481 1757 dbSNP
rs1205784463 1758 dbSNP
rs1330994982 1759 dbSNP
rs1459499553 1763 dbSNP
rs1255541667 1767 dbSNP
rs983366129 1768 dbSNP
rs1217491084 1775 dbSNP
rs546294407 1778 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uuuaggguaggggucCUUGggg 5'
                         ||||   
Target 5' caaggagaauugcuuGAAC--- 3'
5 - 23
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000353258.3 | 3UTR | GAAGCAAGGAGAAUUGCUUGAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE15076 Monocyte-derived dendritic cells 0.93 1.4e-4 0.683 2.1e-2 9 Click to see details
GSE28544 Breast cancer 0.663 2.1e-4 0.617 6.6e-4 24 Click to see details
GSE32688 Pancreatic cancer -0.523 1.1e-3 -0.558 4.5e-4 32 Click to see details
GSE28260 Renal cortex and medulla -0.65 8.1e-3 -0.621 1.2e-2 13 Click to see details
GSE26953 Aortic valvular endothelial cells 0.296 8.0e-2 0.197 1.8e-1 24 Click to see details
GSE21032 Prostate cancer -0.15 8.8e-2 -0.147 9.2e-2 83 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.252 1.1e-1 -0.198 1.7e-1 25 Click to see details
GSE19783 ER+ ER+ breast cancer -0.262 1.3e-1 -0.329 7.8e-2 20 Click to see details
GSE21687 Ependynoma primary tumors 0.14 1.3e-1 0.182 7.5e-2 64 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.241 1.5e-1 0.412 3.6e-2 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.207 1.6e-1 -0.195 1.8e-1 25 Click to see details
GSE38226 Liver fibrosis -0.203 1.9e-1 -0.155 2.5e-1 21 Click to see details
GSE17498 Multiple myeloma 0.104 2.6e-1 0.056 3.7e-1 40 Click to see details
GSE19536 Breast cancer -0.045 3.3e-1 -0.014 4.5e-1 100 Click to see details
GSE19783 ER- ER- breast cancer 0.049 3.3e-1 0.083 2.3e-1 79 Click to see details
GSE19350 CNS germ cell tumors 0.106 3.7e-1 -0.215 2.5e-1 12 Click to see details
GSE42095 Differentiated embryonic stem cells -0.052 4.1e-1 0.057 4.0e-1 23 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
PAAD 0.938 0.03 1.000 0.5 4 Click to see details
KIRC -0.216 0.05 -0.286 0.01 62 Click to see details
BLCA 0.427 0.05 0.282 0.14 16 Click to see details
STAD -0.291 0.07 -0.332 0.04 28 Click to see details
HNSC -0.223 0.08 -0.289 0.04 40 Click to see details
PCPG 0.962 0.09 1.000 0.5 3 Click to see details
CESC 0.881 0.16 0.500 0.33 3 Click to see details
KICH -0.165 0.24 0.147 0.27 20 Click to see details
BRCA -0.068 0.28 -0.016 0.44 78 Click to see details
CHOL -0.229 0.29 -0.500 0.1 8 Click to see details
UCEC 0.129 0.3 0.174 0.24 19 Click to see details
LIHC -0.084 0.31 -0.050 0.38 38 Click to see details
KIRP -0.077 0.34 0.035 0.42 32 Click to see details
LUSC 0.029 0.43 0.089 0.3 38 Click to see details
COAD 0.058 0.45 0.024 0.48 8 Click to see details
ESCA -0.046 0.45 -0.073 0.42 11 Click to see details
PRAD -0.03 0.45 0.214 0.19 19 Click to see details
LUAD -0.047 0.45 -0.017 0.48 9 Click to see details
THCA -0.014 0.46 -0.057 0.33 59 Click to see details
THCA -0.014 0.46 -0.057 0.33 59 Click to see details
THCA -0.014 0.46 -0.057 0.33 59 Click to see details
131 hsa-miR-23a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038958 ATF1 activating transcription factor 1 1 1
MIRT057661 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT395438 NFKBID NFKB inhibitor delta 2 2
MIRT463884 WNT7B Wnt family member 7B 2 4
MIRT475804 HDGF heparin binding growth factor 2 2
MIRT478528 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT479278 CHD4 chromodomain helicase DNA binding protein 4 2 6
MIRT492564 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT500353 ZNF385A zinc finger protein 385A 2 2
MIRT509788 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT511566 HIST3H2BB histone cluster 3 H2B family member b 2 4
MIRT525450 GPATCH2L G-patch domain containing 2 like 2 2
MIRT539558 CNKSR3 CNKSR family member 3 2 4
MIRT540034 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT540225 SAMD5 sterile alpha motif domain containing 5 2 2
MIRT540242 RGS17 regulator of G protein signaling 17 2 2
MIRT540871 ZBTB24 zinc finger and BTB domain containing 24 2 2
MIRT559065 C19orf47 chromosome 19 open reading frame 47 2 4
MIRT560685 HIST1H1T histone cluster 1 H1 family member t 2 2
MIRT565593 SLC35G1 solute carrier family 35 member G1 2 2
MIRT565642 SKI SKI proto-oncogene 2 2
MIRT576747 Tmem127 transmembrane protein 127 2 2
MIRT607712 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT615682 NAV2 neuron navigator 2 2 2
MIRT617337 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT617378 FAM227A family with sequence similarity 227 member A 2 2
MIRT620855 SERPING1 serpin family G member 1 2 2
MIRT625112 SLC1A5 solute carrier family 1 member 5 2 2
MIRT625124 NUP93 nucleoporin 93 2 2
MIRT625898 LINC00632 long intergenic non-protein coding RNA 632 2 2
MIRT626016 XRCC2 X-ray repair cross complementing 2 2 2
MIRT626481 ADAT1 adenosine deaminase, tRNA specific 1 2 2
MIRT626573 MED7 mediator complex subunit 7 2 2
MIRT626814 PRR11 proline rich 11 2 2
MIRT628136 HM13 histocompatibility minor 13 2 2
MIRT630771 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT633133 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT636950 APTX aprataxin 2 2
MIRT637802 GGPS1 geranylgeranyl diphosphate synthase 1 2 2
MIRT638622 GSR glutathione-disulfide reductase 2 4
MIRT642196 SMAGP small cell adhesion glycoprotein 2 2
MIRT645121 HES2 hes family bHLH transcription factor 2 2 2
MIRT645344 AGTPBP1 ATP/GTP binding protein 1 2 2
MIRT646564 ALDH5A1 aldehyde dehydrogenase 5 family member A1 2 2
MIRT649243 TRIM65 tripartite motif containing 65 2 2
MIRT651810 USP49 ubiquitin specific peptidase 49 2 2
MIRT652137 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT652668 TIMELESS timeless circadian clock 2 2
MIRT655894 NEK9 NIMA related kinase 9 2 2
MIRT656564 LYRM7 LYR motif containing 7 2 2
MIRT657194 IKZF3 IKAROS family zinc finger 3 2 2
MIRT657907 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT660207 BMPR1A bone morphogenetic protein receptor type 1A 2 2
MIRT660619 ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2 2
MIRT660826 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT660986 ABHD2 abhydrolase domain containing 2 2 2
MIRT662232 PGBD4 piggyBac transposable element derived 4 2 2
MIRT663691 ZNF347 zinc finger protein 347 2 2
MIRT665577 TUBD1 tubulin delta 1 2 2
MIRT666149 SP2 Sp2 transcription factor 2 2
MIRT666310 SLC22A3 solute carrier family 22 member 3 2 2
MIRT666457 SCRG1 stimulator of chondrogenesis 1 2 2
MIRT667716 KIAA1468 KIAA1468 2 2
MIRT668329 FKBP5 FK506 binding protein 5 2 2
MIRT668370 FBXO47 F-box protein 47 2 2
MIRT669304 C17orf75 chromosome 17 open reading frame 75 2 2
MIRT669538 ALG9 ALG9, alpha-1,2-mannosyltransferase 2 2
MIRT671681 ADK adenosine kinase 2 2
MIRT672177 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT673604 HPSE heparanase 2 2
MIRT673749 ZNF333 zinc finger protein 333 2 2
MIRT674807 FAM229B family with sequence similarity 229 member B 2 2
MIRT675286 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT675391 SVOP SV2 related protein 2 2
MIRT675788 MED28 mediator complex subunit 28 2 2
MIRT676151 OGFOD1 2-oxoglutarate and iron dependent oxygenase domain containing 1 2 2
MIRT676499 GJD3 gap junction protein delta 3 2 2
MIRT676621 CSNK1E casein kinase 1 epsilon 2 2
MIRT676644 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT676711 METTL14 methyltransferase like 14 2 2
MIRT676809 SHROOM4 shroom family member 4 2 2
MIRT677036 FOXO3 forkhead box O3 2 2
MIRT677062 NT5C2 5'-nucleotidase, cytosolic II 2 2
MIRT677086 SMIM15 small integral membrane protein 15 2 2
MIRT677193 MURC caveolae associated protein 4 2 2
MIRT677273 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT677345 POC1A POC1 centriolar protein A 2 2
MIRT677504 SLC10A6 solute carrier family 10 member 6 2 2
MIRT677526 OCIAD2 OCIA domain containing 2 2 2
MIRT677661 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT677727 SSR1 signal sequence receptor subunit 1 2 2
MIRT677803 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT678144 SLC4A4 solute carrier family 4 member 4 2 2
MIRT678376 VTA1 vesicle trafficking 1 2 2
MIRT678708 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT678868 FAM118A family with sequence similarity 118 member A 2 2
MIRT679039 LACTB lactamase beta 2 2
MIRT679081 PURB purine rich element binding protein B 2 2
MIRT679137 SYK spleen associated tyrosine kinase 2 2
MIRT679299 SSBP2 single stranded DNA binding protein 2 2 2
MIRT679741 CABP4 calcium binding protein 4 2 2
MIRT679946 AS3MT arsenite methyltransferase 2 2
MIRT679976 E2F2 E2F transcription factor 2 2 2
MIRT683628 MTO1 mitochondrial tRNA translation optimization 1 2 2
MIRT683901 PSMB9 proteasome subunit beta 9 2 2
MIRT684172 MOG myelin oligodendrocyte glycoprotein 2 2
MIRT684231 C20orf144 chromosome 20 open reading frame 144 2 2
MIRT685403 C1orf158 chromosome 1 open reading frame 158 2 2
MIRT686253 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT687513 NCKAP1 NCK associated protein 1 2 2
MIRT688243 FITM2 fat storage inducing transmembrane protein 2 2 2
MIRT688315 FAM151B family with sequence similarity 151 member B 2 2
MIRT688733 CNDP1 carnosine dipeptidase 1 2 2
MIRT689031 ANGPTL3 angiopoietin like 3 2 2
MIRT698207 TMEM248 transmembrane protein 248 2 2
MIRT699859 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT709954 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT711541 MSH3 mutS homolog 3 2 2
MIRT712077 WDR37 WD repeat domain 37 2 2
MIRT715312 POLR2E RNA polymerase II subunit E 2 2
MIRT715725 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT715748 HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like 2 2
MIRT717604 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT717875 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT718042 NIPAL2 NIPA like domain containing 2 2 2
MIRT718829 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT724037 CAMK2N2 calcium/calmodulin dependent protein kinase II inhibitor 2 2 2
MIRT733305 TNF tumor necrosis factor 1 0
MIRT734941 HSPA1B heat shock protein family A (Hsp70) member 1B 3 0
MIRT737343 IGF2 insulin like growth factor 2 3 0
MIRT737546 PTEN phosphatase and tensin homolog 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-23a 1'-Acetoxychavicol acetate (ACA) NULL 119104 Microarray HN4 cell line 24317043 2014 down-regulated
miR-23a 5-Fluorouracil approved 3385 Quantitative real-time PCR colon cancer cells 17702597 2007 up-regulated
miR-23a Curcumin NULL 969516 Microarray BxPC-3 human pancreatic carcinoma cell line 18347134 2008 up-regulated
miR-23a Enoxacin approved 3229 Quantitative real-time PCR HEK293 cells 18641635 2008 up-regulated
miR-23a 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR endometrial stromal 19088369 2008 down-regulated
miR-23a 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR glandular epithelial cells 19088369 2008 down-regulated
miR-23a Medroxyprogesterone acetate approved 6279 Quantitative real-time PCR endometrial stromal 19088369 2008 down-regulated
miR-23a Medroxyprogesterone acetate approved 6279 Quantitative real-time PCR glandular epithelial cells 19088369 2008 up-regulated
miR-23a 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
miR-23a Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miR-23a Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-23a Bio-Oss NULL NULL Microarray osteoblast-like cell line (MG63) 20224834 2010 up-regulated
miR-23a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-23a 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 up-regulated
miR-23a Trastuzumab approved NULL Microarray BT474 cells 22384020 2012 up-regulated
miR-23a Trastuzumab approved NULL Microarray SKBR3 cells. 22384020 2012 up-regulated
miR-23a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Quantitative real-time PCR thymus 23024791 2012 down-regulated
miR-23a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-23a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 up-regulated
miR-23a Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 up-regualted
miR-23a Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
miR-23a Comfrey NULL 6440495 Microarray rat liver 21370286 2011 up-regulated
miR-23a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-23a Ethanol NULL 702 Quantitative real-time PCR zebrafish embryos 22298809 2012 down-regulated
miR-23a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 up-regulated
miR-23a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 up-regulated
miR-23a Morphine approved 5288826 Microarray human monocyte-derived macrophages (h-mdms) infection with HIV-1 20564181 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive Low Breast Cancer cell line (MDA-MB-231)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (BGC823)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC-7901)
hsa-mir-23a Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-mir-23a Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-23a Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive cell line (OE19)
hsa-mir-23a Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-23a Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive cell line (SGC-7901)
hsa-miR-23a-5p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-23a-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-23a-5p Palbociclib 5330286 NSC758247 approved resistant High Breast Cancer cell line (T47D)
hsa-miR-23a-5p Arsenic trioxide 261004 NSC759274 approved sensitive Low Acute Myeloid Leukemia cell line (U937, Kasumi-1, THP-1, Jurkat E6.1, SUP B15)
hsa-miR-23a-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-23a-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-23a-5p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-23a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-23a-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-23a-5p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-23a-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-23a-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-23a-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-23a-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-23a-5p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-23a-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (MDA-231)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-23a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-23a-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-23a-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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