pre-miRNA Information
pre-miRNA hsa-mir-4749   
Genomic Coordinates chr19: 49854591 - 49854651
Description Homo sapiens miR-4749 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4749-3p
Sequence 42| CGCCCCUCCUGCCCCCACAG |61
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN19730808 2 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs147943327 1 dbSNP
rs148982635 2 dbSNP
rs372882504 3 dbSNP
rs200056596 4 dbSNP
rs570340094 5 dbSNP
rs778438436 11 dbSNP
rs748573000 13 dbSNP
rs770230641 14 dbSNP
rs201103722 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FCHSD1   
Synonyms NWK2
Description FCH and double SH3 domains 1
Transcript NM_033449   
Expression
Putative miRNA Targets on FCHSD1
3'UTR of FCHSD1
(miRNA target sites are highlighted)
>FCHSD1|NM_033449|3'UTR
   1 AGGCCAGGGAAGCCTTGACCCCCAGTGATGCTGCTGTCCCTATCTTCAAGCTGTCAGACCACACCATCAATGATCCAGAG
  81 CAACACAGCCAAAAGCTGGAATCGCCCTTATTTCCACCCTCACCTCCAAGGGTGGAAACTTGCCCCTTCCCATTTCTAGA
 161 GCTGGAACCCACTCCTTTTTTTCCCATTGTTCTATCATCTCTAGGACCGGAACTACCTTCTCTTCTGTCATGACCCTATC
 241 TAGGGTGGTGAAATGCCTGAAATCTCTGGGGCTGGAAACCATCCATCAAGGTCTCTAGTAGTTCTGGCCCACCTCTTTCC
 321 CCACCCTGGCTCCATGACCCACCCCACTCTGGATGCCAGGGTCACTGGGGTTGGGCTGGGGAGAGGAACAGGCCTTGGGA
 401 ATCAGGAGCTGGAGCCAGGATGCGAAGCAGCTGTAATGGTCTGAGCGGATTTATTGACAATGAATAAAGGGCACGAAGGC
 481 CAGGCCAGGGCCTGGGCCTCTTGTGCTAAGAGGGCAGGGGGCCTACGGTGCTATTGCTTTAGGGGCCCACCACGGGCAGG
 561 GGCCTGCTCCCAGCTGCCACGCTCTATCATATGGAGCGAGGTGTTGGGGAAGGCGGGGCAGGCAGCCTGTTGCAGGCAGG
 641 GGAAGGAGAAGAGACTGAGGGGCTGTGACCTCTCCTGAGGCCCCCAGCCTGAGACTGTGCAACTCCAGGTGGAAGTAGAG
 721 CTGGTCCCTCAGCTGGGGGGCAGTGCTGTCCAGTGGAGGGGAGGGCTTTCACGCCCACCCACCCCCTGGCCCTGCCAGCT
 801 GGTAGTCCATCAGCACAATGAAGGAGACTTGGAGAAGAGGAAGAATAACACTGTTGCTTCCTGTTCAAGCTGTGTCCAGC
 881 TTTTCCCCTGGGGCTCCAGGACCTTCCCTACCTCCACCACCAAACCAAGGGATTTATAGCAAAGGCTAAGCCTGCAGTTT
 961 ACTCGGGGGGTTCAGGGAGCCGAAAGGCTTAAATAGTTTAAGTAGGTGATGGGAAGATGAGATTACCTCATTTAGGGCTC
1041 AGGCAGACTCACCTCACATACTCCCTGCTCCCTGTGGTAGAGACACCTGAGAGAAAGGGGAGGGGTCAACAATGAGAGAC
1121 CAGGAGTAGGTCCTATCAGTGCCCCCCAGAGTAGAGAGCAATAAGAGCCCAGCCCAGTGCAGTCCCGGCTGTGTTTTCCT
1201 ACCTGGTGATCAGAAGTGTCTGGTTTGCTTGGCTGCCCATTTGCCTCTTGAGTGGGCAGCCCTGGGCTTGGGCCCCTCCC
1281 TCCGGCCCTCAGTGTTGGCTCTGCAGAAGCTCTGGGGTTCCCTTCAAGTGCACGAGGGGTTAGGCTGCTGTCCCTGAGTC
1361 CTCCATTCTGTACTGGGGGGCTGGCTAGGACCTGGGGCTGTGGCCTCTCAGGGGGCAGCCTCTCCATGGCAGGCATCCCT
1441 GCCTTGGGCTGCCCTCCCCCAGACCCCTGACCACCCCCTGGGTCCTGTCCCCCACCAGAGCCCCAGCTCCTGTCTGTGGG
1521 GGAGCCATCACGGTGTTCGTGCAGTCCATAGCGCTTCTCAATGTGTGTCACCCGGAACCTGGGAGGGGAGGGAACACTGG
1601 GGTTTAGGACCACAACTCAGAGGCTGCTTGGCCCTCCCCTCTGACCAGGGACATCCTGAGTTTGGTGGCTACTTCCCTCT
1681 GGCCTAAGGTAGGGGAGGCCTTCTCAGATTGTGGGGCACATTGTGTAGCCTGACTTCTGCCGGAGCTCCCAGTCCAGGAG
1761 GAAAGAGCCAAGGCCCACTTTTGGGATCAGGTGCCTGATCACTGGGCCCCCTACCTCAGCCCCCCTTTCCCTGGAGCACC
1841 TGCCCCACCTGCCCACAGAGAACACAGTGGTCTCCCCTGTCCGGGGGCGGCTTTTTCCTTCCTTGGAGCGTCCCTGACGG
1921 ACAAGTGGAGGCCTCTTGCTGCGGCTGCAATGGAGGCAAGGGGCTGCAGAGCCCAGGTGCACTGTGTGATGATGGGAGGG
2001 GGCTCCGTCCTGCAGGCTGGAGGTGGCATCCACACTGGACAGCAGGGAGGAGGGGAGTGAGGGTAACATTTCCATTTCCC
2081 TTCATGTTTTGTTTCTTACGTTCTTTCAGCATGCTCCTTAAAACCCCAGAAGCCCCAATTTCCCCAAGCCCCATTTTTTC
2161 TTGTCTTTATCTAATAAACTCAATATTAAGATGTTAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gacacCCCCGUC-----CUCCCCGc 5'
               || | ||     ||||||| 
Target 5' gggaaGGAGAAGAGACTGAGGGGCt 3'
640 - 664 143.00 -15.70
2
miRNA  3' gaCACCCCCGUCCUCCCCGc 5'
            || |||| ||| ||||| 
Target 5' gtGTTGGGGAAGGCGGGGCa 3'
601 - 620 142.00 -25.30
3
miRNA  3' gaCACCCCCGUCCUCCCCgc 5'
            |||  | ::|||||||  
Target 5' gtGTGATGATGGGAGGGGgc 3'
1984 - 2003 138.00 -22.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31553511 3 COSMIC
COSN26639347 4 COSMIC
COSN16130552 32 COSMIC
COSN31492399 52 COSMIC
COSN26586335 86 COSMIC
COSN23016557 104 COSMIC
COSN20101935 211 COSMIC
COSN9408617 240 COSMIC
COSN28760362 329 COSMIC
COSN16131432 403 COSMIC
COSN31566159 424 COSMIC
COSN31569703 427 COSMIC
COSN26678784 441 COSMIC
COSN31589505 487 COSMIC
COSN31550216 518 COSMIC
COSN1308517 535 COSMIC
COSN2073501 579 COSMIC
COSN26602272 612 COSMIC
COSN26677877 614 COSMIC
COSN30098879 637 COSMIC
COSN28871046 735 COSMIC
COSN20075420 772 COSMIC
COSN28887615 785 COSMIC
COSN7877781 802 COSMIC
COSN28685000 813 COSMIC
COSN30159040 946 COSMIC
COSN30503792 954 COSMIC
COSN28647297 965 COSMIC
COSN30524246 973 COSMIC
COSN14144681 982 COSMIC
COSN30176811 1019 COSMIC
COSN30177227 1029 COSMIC
COSM366581 1061 COSMIC
COSM7856131 1065 COSMIC
COSM7678496 1070 COSMIC
COSM736584 1074 COSMIC
COSM6662806 1091 COSMIC
COSM9037420 1093 COSMIC
COSM8179635 1096 COSMIC
COSN31576233 1106 COSMIC
COSN23016556 1114 COSMIC
COSN30511057 1126 COSMIC
COSN31555260 1141 COSMIC
COSN8892354 1147 COSMIC
COSN26548724 1170 COSMIC
COSN26729105 1184 COSMIC
COSN30499874 1185 COSMIC
COSN14144676 1186 COSMIC
COSN26556806 1186 COSMIC
COSN14144675 1187 COSMIC
COSN30185190 1187 COSMIC
COSM7535752 1207 COSMIC
COSM295185 1220 COSMIC
COSM1063522 1228 COSMIC
COSM4159581 1235 COSMIC
COSM8039990 1254 COSMIC
COSM9438841 1280 COSMIC
COSM8521072 1283 COSMIC
COSM1754076 1290 COSMIC
COSM7594736 1299 COSMIC
COSM5918800 1301 COSMIC
COSM8319217 1320 COSMIC
COSM5604680 1321 COSMIC
COSM7964308 1321 COSMIC
COSM5961790 1328 COSMIC
COSM3209080 1330 COSMIC
COSM9631883 1333 COSMIC
COSM3697046 1334 COSMIC
COSM7955802 1338 COSMIC
COSM4585574 1352 COSMIC
COSM1223511 1355 COSMIC
COSM7848144 1356 COSMIC
COSM736585 1361 COSMIC
COSM7494128 1374 COSMIC
COSM7908302 1376 COSMIC
COSM3852236 1381 COSMIC
COSM4847372 1409 COSMIC
COSM5733499 1427 COSMIC
COSM1434738 1436 COSMIC
COSM3365890 1437 COSMIC
COSM8291887 1437 COSMIC
COSM1063521 1452 COSMIC
COSM4937046 1474 COSMIC
COSM8564319 1474 COSMIC
COSM9227827 1483 COSMIC
COSM9521217 1489 COSMIC
COSM3611760 1491 COSMIC
COSM8138731 1493 COSMIC
COSM7140856 1495 COSMIC
COSM4159580 1496 COSMIC
COSM8940346 1500 COSMIC
COSM4585573 1514 COSMIC
COSM5867672 1522 COSMIC
COSM8767586 1527 COSMIC
COSM1063520 1536 COSMIC
COSM3975290 1552 COSMIC
COSM7261029 1553 COSMIC
COSN18451939 1598 COSMIC
COSN30502891 1617 COSMIC
COSN30456856 1622 COSMIC
COSN30107162 1624 COSMIC
COSN26976299 1627 COSMIC
COSN31497884 1634 COSMIC
COSN19750886 1677 COSMIC
COSN18245850 1739 COSMIC
COSN28658582 1741 COSMIC
COSN23016554 1749 COSMIC
COSN24310327 1758 COSMIC
COSN32056516 1797 COSMIC
COSN30172596 1800 COSMIC
COSN5272594 1805 COSMIC
COSN30519794 1806 COSMIC
COSM8198334 1842 COSMIC
COSM8781572 1843 COSMIC
COSM9308366 1858 COSMIC
COSM8950348 1867 COSMIC
COSM3209074 1882 COSMIC
COSM121128 1883 COSMIC
COSM736586 1883 COSMIC
COSM3611759 1885 COSMIC
COSM8695698 1885 COSMIC
COSM1186860 1889 COSMIC
COSM1434737 1910 COSMIC
COSM3209073 1919 COSMIC
COSM7906785 1919 COSMIC
COSM8202731 1934 COSMIC
COSM8720709 1935 COSMIC
COSM7782613 1938 COSMIC
COSM8466049 1942 COSMIC
COSM9154342 1952 COSMIC
COSM3761009 1955 COSMIC
COSM6836606 1957 COSMIC
COSM6836605 1964 COSMIC
COSM3209071 1972 COSMIC
COSM4790433 2007 COSMIC
COSM7769946 2009 COSMIC
COSM8077515 2031 COSMIC
COSM8830835 2042 COSMIC
COSN30468242 2061 COSMIC
COSN30495107 2066 COSMIC
COSN20075272 2071 COSMIC
COSN508249 2073 COSMIC
COSN26976297 2125 COSMIC
COSN30192950 2149 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs764848520 3 dbSNP
rs1199770291 4 dbSNP
rs200503843 9 dbSNP
rs752937207 17 dbSNP
rs1259271523 20 dbSNP
rs1218857472 21 dbSNP
rs1488599278 26 dbSNP
rs763183547 29 dbSNP
rs1198534929 30 dbSNP
rs773509569 36 dbSNP
rs1244493370 38 dbSNP
rs201722475 39 dbSNP
rs564562335 42 dbSNP
rs544381992 44 dbSNP
rs1025728394 49 dbSNP
rs1226977340 52 dbSNP
rs114773384 55 dbSNP
rs1170803026 58 dbSNP
rs1316644019 64 dbSNP
rs1468220871 68 dbSNP
rs1178474408 71 dbSNP
rs922457489 72 dbSNP
rs1448801793 76 dbSNP
rs1288522204 88 dbSNP
rs370266583 99 dbSNP
rs965216350 103 dbSNP
rs1018620229 104 dbSNP
rs1360047662 107 dbSNP
rs1006835916 117 dbSNP
rs1279297862 118 dbSNP
rs1400564964 119 dbSNP
rs143284170 124 dbSNP
rs1041381890 126 dbSNP
rs1222261750 142 dbSNP
rs1312286857 159 dbSNP
rs372926038 160 dbSNP
rs541855186 169 dbSNP
rs999139462 170 dbSNP
rs902279180 171 dbSNP
rs1240011629 178 dbSNP
rs1486683144 182 dbSNP
rs939938761 183 dbSNP
rs1356725506 184 dbSNP
rs1267978354 186 dbSNP
rs1479316940 195 dbSNP
rs1201543896 204 dbSNP
rs1046092837 208 dbSNP
rs950238702 209 dbSNP
rs1158560211 215 dbSNP
rs149876519 216 dbSNP
rs1160948 217 dbSNP
rs35590706 217 dbSNP
rs3833652 217 dbSNP
rs4042097 217 dbSNP
rs1298993675 222 dbSNP
rs1385921788 229 dbSNP
rs1185704504 238 dbSNP
rs1285771161 241 dbSNP
rs1368842174 243 dbSNP
rs1223713642 244 dbSNP
rs572777481 247 dbSNP
rs895957764 253 dbSNP
rs552894518 259 dbSNP
rs539208005 282 dbSNP
rs1216938229 283 dbSNP
rs1290534798 289 dbSNP
rs1489805604 292 dbSNP
rs920714177 295 dbSNP
rs980210178 296 dbSNP
rs1481578469 299 dbSNP
rs187515 300 dbSNP
rs1048452 304 dbSNP
rs1203837989 311 dbSNP
rs1441574701 316 dbSNP
rs1159493776 319 dbSNP
rs910125612 322 dbSNP
rs1048453 323 dbSNP
rs1293282219 329 dbSNP
rs1024464886 334 dbSNP
rs984158207 336 dbSNP
rs1339492852 338 dbSNP
rs1442185991 339 dbSNP
rs1048455 341 dbSNP
rs1278263976 345 dbSNP
rs1048456 346 dbSNP
rs1374923207 349 dbSNP
rs1240182790 357 dbSNP
rs1312471619 373 dbSNP
rs1392256795 376 dbSNP
rs1376198664 377 dbSNP
rs1306776260 379 dbSNP
rs1409723354 385 dbSNP
rs1290389515 386 dbSNP
rs993377819 392 dbSNP
rs1202389125 399 dbSNP
rs1234483723 401 dbSNP
rs1459152841 403 dbSNP
rs1306206486 409 dbSNP
rs929919644 412 dbSNP
rs1384684983 413 dbSNP
rs918691621 414 dbSNP
rs556991972 421 dbSNP
rs965830328 423 dbSNP
rs1028528900 424 dbSNP
rs1327463450 426 dbSNP
rs781491352 430 dbSNP
rs191608161 438 dbSNP
rs1403015420 439 dbSNP
rs1018129244 446 dbSNP
rs985693917 448 dbSNP
rs958013984 454 dbSNP
rs1032186620 458 dbSNP
rs999149577 464 dbSNP
rs1284379507 470 dbSNP
rs902164244 471 dbSNP
rs1024694156 474 dbSNP
rs939809639 475 dbSNP
rs1275028868 479 dbSNP
rs1318608331 482 dbSNP
rs1013366780 486 dbSNP
rs1202945848 489 dbSNP
rs1490491236 494 dbSNP
rs1460013135 497 dbSNP
rs894869747 500 dbSNP
rs1048336900 501 dbSNP
rs536764365 502 dbSNP
rs116046686 508 dbSNP
rs548187714 509 dbSNP
rs948845973 514 dbSNP
rs879261835 520 dbSNP
rs937500045 526 dbSNP
rs888715992 527 dbSNP
rs1403305613 533 dbSNP
rs1397218369 536 dbSNP
rs1240722987 543 dbSNP
rs1325420040 545 dbSNP
rs1428212892 547 dbSNP
rs1279924021 549 dbSNP
rs1319149564 551 dbSNP
rs1048651294 553 dbSNP
rs534654711 554 dbSNP
rs1371681045 555 dbSNP
rs1409815853 556 dbSNP
rs1279610390 560 dbSNP
rs918618108 561 dbSNP
rs1191270903 562 dbSNP
rs1265840482 563 dbSNP
rs1478327775 566 dbSNP
rs760999279 572 dbSNP
rs1427742450 576 dbSNP
rs944174878 580 dbSNP
rs186830089 581 dbSNP
rs1383604362 587 dbSNP
rs1398644896 589 dbSNP
rs985318706 590 dbSNP
rs547323573 594 dbSNP
rs1289718894 596 dbSNP
rs958071851 597 dbSNP
rs1404062523 598 dbSNP
rs978979249 600 dbSNP
rs778650886 601 dbSNP
rs968378000 604 dbSNP
rs977950874 607 dbSNP
rs1350001518 612 dbSNP
rs533515996 614 dbSNP
rs570976701 615 dbSNP
rs1158126517 616 dbSNP
rs551016096 618 dbSNP
rs1480728982 627 dbSNP
rs1267205813 629 dbSNP
rs573268180 629 dbSNP
rs1200174696 630 dbSNP
rs757107001 636 dbSNP
rs996885597 637 dbSNP
rs530892699 641 dbSNP
rs1013668289 645 dbSNP
rs1360707422 651 dbSNP
rs1423774843 653 dbSNP
rs1392587941 657 dbSNP
rs562236997 659 dbSNP
rs775888438 660 dbSNP
rs1387318769 665 dbSNP
rs1328051045 667 dbSNP
rs1335265304 674 dbSNP
rs1450593973 677 dbSNP
rs894930967 688 dbSNP
rs1261782704 691 dbSNP
rs1368199052 697 dbSNP
rs1206600850 699 dbSNP
rs1264106682 700 dbSNP
rs1489654165 701 dbSNP
rs1210993510 706 dbSNP
rs1250372184 717 dbSNP
rs1033815092 718 dbSNP
rs753624568 722 dbSNP
rs1266643541 723 dbSNP
rs1001725897 727 dbSNP
rs1228098573 728 dbSNP
rs1004085355 734 dbSNP
rs1324922882 737 dbSNP
rs1337933957 761 dbSNP
rs1279591028 763 dbSNP
rs1161245890 764 dbSNP
rs78047479 772 dbSNP
rs556933991 773 dbSNP
rs1334019675 774 dbSNP
rs559176808 779 dbSNP
rs112543254 780 dbSNP
rs574168742 785 dbSNP
rs1177586259 788 dbSNP
rs994443160 791 dbSNP
rs1421714431 795 dbSNP
rs1195971848 796 dbSNP
rs1478160808 798 dbSNP
rs1236844571 801 dbSNP
rs1448896833 802 dbSNP
rs773444868 811 dbSNP
rs1444057941 812 dbSNP
rs117127684 813 dbSNP
rs1197748849 818 dbSNP
rs1377714445 822 dbSNP
rs1315716474 823 dbSNP
rs1259539336 825 dbSNP
rs1218726989 830 dbSNP
rs1354957514 831 dbSNP
rs1323901829 833 dbSNP
rs931207235 839 dbSNP
rs1281921508 840 dbSNP
rs748411110 845 dbSNP
rs766527426 855 dbSNP
rs1337847821 862 dbSNP
rs1044423092 866 dbSNP
rs576935504 867 dbSNP
rs1398404728 871 dbSNP
rs556863623 872 dbSNP
rs1410605800 874 dbSNP
rs543632419 884 dbSNP
rs944002302 885 dbSNP
rs1057136210 888 dbSNP
rs1257759875 890 dbSNP
rs911313235 892 dbSNP
rs139324945 897 dbSNP
rs1477656432 902 dbSNP
rs1371113448 914 dbSNP
rs1467164617 915 dbSNP
rs181346623 917 dbSNP
rs752330892 923 dbSNP
rs534561023 925 dbSNP
rs1401166738 927 dbSNP
rs979010205 931 dbSNP
rs767024402 939 dbSNP
rs1447289234 940 dbSNP
rs759965004 941 dbSNP
rs968953480 947 dbSNP
rs1295387298 957 dbSNP
rs565679679 960 dbSNP
rs925141121 961 dbSNP
rs1246988853 964 dbSNP
rs41098 965 dbSNP
rs144355880 966 dbSNP
rs571156836 969 dbSNP
rs553398650 971 dbSNP
rs1265351390 973 dbSNP
rs1199312048 976 dbSNP
rs572286753 981 dbSNP
rs371336881 1003 dbSNP
rs1019400382 1005 dbSNP
rs1294689887 1006 dbSNP
rs779937041 1008 dbSNP
rs1473760952 1010 dbSNP
rs758379983 1016 dbSNP
rs1177802411 1017 dbSNP
rs1456238226 1023 dbSNP
rs1239624770 1024 dbSNP
rs1198959405 1026 dbSNP
rs745334394 1027 dbSNP
rs991839285 1029 dbSNP
rs778425892 1031 dbSNP
rs1229504838 1037 dbSNP
rs377702069 1040 dbSNP
rs1003949336 1041 dbSNP
rs1316286070 1044 dbSNP
rs373731297 1054 dbSNP
rs763720485 1055 dbSNP
rs959261951 1057 dbSNP
rs755337622 1058 dbSNP
rs752134327 1063 dbSNP
rs766941038 1065 dbSNP
rs763581454 1067 dbSNP
rs201826457 1070 dbSNP
rs202083613 1072 dbSNP
rs1407109074 1076 dbSNP
rs1385805923 1080 dbSNP
rs761858851 1082 dbSNP
rs1401175121 1084 dbSNP
rs1437745242 1085 dbSNP
rs776910084 1086 dbSNP
rs1177547824 1088 dbSNP
rs1487975984 1092 dbSNP
rs1279388418 1093 dbSNP
rs768802618 1099 dbSNP
rs1223156625 1102 dbSNP
rs951764332 1104 dbSNP
rs746786469 1106 dbSNP
rs775287532 1110 dbSNP
rs771957885 1112 dbSNP
rs1352126800 1114 dbSNP
rs1311979583 1115 dbSNP
rs1027191338 1118 dbSNP
rs1420334322 1120 dbSNP
rs375795159 1131 dbSNP
rs778773771 1133 dbSNP
rs1273245983 1134 dbSNP
rs149611844 1135 dbSNP
rs1283381100 1142 dbSNP
rs367620461 1147 dbSNP
rs1183863930 1148 dbSNP
rs1267916462 1148 dbSNP
rs1366345829 1156 dbSNP
rs748788130 1157 dbSNP
rs755741628 1158 dbSNP
rs751928779 1161 dbSNP
rs1159600702 1162 dbSNP
rs377253130 1163 dbSNP
rs1179536130 1165 dbSNP
rs758921383 1170 dbSNP
rs369105841 1173 dbSNP
rs1480554790 1178 dbSNP
rs1261907910 1180 dbSNP
rs1213794649 1181 dbSNP
rs1487616147 1182 dbSNP
rs32956 1184 dbSNP
rs199786252 1185 dbSNP
rs764330298 1186 dbSNP
rs769298620 1187 dbSNP
rs761133000 1189 dbSNP
rs775199549 1191 dbSNP
rs1346368861 1193 dbSNP
rs1365315453 1195 dbSNP
rs760874296 1195 dbSNP
rs1277694297 1200 dbSNP
rs771839658 1205 dbSNP
rs747660127 1213 dbSNP
rs759392634 1217 dbSNP
rs1289314478 1221 dbSNP
rs1274666385 1222 dbSNP
rs774311343 1228 dbSNP
rs1357282024 1229 dbSNP
rs1222648973 1233 dbSNP
rs11742646 1235 dbSNP
rs1355497419 1236 dbSNP
rs1240411349 1238 dbSNP
rs748779251 1239 dbSNP
rs1422430744 1240 dbSNP
rs762186023 1243 dbSNP
rs1478484169 1249 dbSNP
rs934732291 1250 dbSNP
rs1049731746 1252 dbSNP
rs1187685019 1255 dbSNP
rs200320253 1270 dbSNP
rs924668013 1272 dbSNP
rs769500107 1277 dbSNP
rs532286514 1279 dbSNP
rs372439670 1283 dbSNP
rs543245703 1284 dbSNP
rs1488848519 1285 dbSNP
rs758833121 1286 dbSNP
rs1252704246 1287 dbSNP
rs750797330 1288 dbSNP
rs779454867 1293 dbSNP
rs936785930 1294 dbSNP
rs1225443430 1299 dbSNP
rs1413562420 1300 dbSNP
rs1395442179 1301 dbSNP
rs369892061 1306 dbSNP
rs569973650 1307 dbSNP
rs1167546651 1309 dbSNP
rs764086935 1311 dbSNP
rs1399113551 1317 dbSNP
rs768261083 1322 dbSNP
rs35340436 1325 dbSNP
rs760800991 1325 dbSNP
rs1396718570 1326 dbSNP
rs752911612 1328 dbSNP
rs767764451 1329 dbSNP
rs759302837 1330 dbSNP
rs375807322 1333 dbSNP
rs770859414 1334 dbSNP
rs762800363 1337 dbSNP
rs772716969 1341 dbSNP
rs769418606 1348 dbSNP
rs773346518 1351 dbSNP
rs747731609 1352 dbSNP
rs1042238956 1355 dbSNP
rs574587182 1362 dbSNP
rs780963876 1363 dbSNP
rs554655827 1374 dbSNP
rs541147231 1375 dbSNP
rs1246446522 1377 dbSNP
rs1375963159 1380 dbSNP
rs1329029383 1381 dbSNP
rs779178806 1391 dbSNP
rs1396736347 1392 dbSNP
rs757716395 1393 dbSNP
rs749774266 1395 dbSNP
rs1367247458 1397 dbSNP
rs1440645389 1398 dbSNP
rs778319234 1400 dbSNP
rs1236473571 1407 dbSNP
rs572034845 1411 dbSNP
rs992464662 1414 dbSNP
rs752821611 1415 dbSNP
rs1472017213 1416 dbSNP
rs147092968 1418 dbSNP
rs951129844 1422 dbSNP
rs141623307 1433 dbSNP
rs199675831 1434 dbSNP
rs1487509577 1437 dbSNP
rs1294037155 1438 dbSNP
rs762859903 1441 dbSNP
rs1192232162 1446 dbSNP
rs772107241 1449 dbSNP
rs773022132 1452 dbSNP
rs1240873689 1453 dbSNP
rs765309159 1455 dbSNP
rs995347857 1456 dbSNP
rs761387148 1458 dbSNP
rs1338403119 1459 dbSNP
rs139146106 1460 dbSNP
rs200210180 1463 dbSNP
rs549495978 1464 dbSNP
rs771194230 1471 dbSNP
rs749701664 1472 dbSNP
rs369910947 1473 dbSNP
rs756634349 1476 dbSNP
rs748182762 1477 dbSNP
rs951816613 1478 dbSNP
rs202176294 1479 dbSNP
rs1200200113 1482 dbSNP
rs1026030528 1485 dbSNP
rs1487941975 1486 dbSNP
rs781250282 1489 dbSNP
rs1485328630 1490 dbSNP
rs994346456 1492 dbSNP
rs146298065 1493 dbSNP
rs758102055 1494 dbSNP
rs372907773 1495 dbSNP
rs750295136 1495 dbSNP
rs17855844 1496 dbSNP
rs1346977425 1498 dbSNP
rs1477679158 1499 dbSNP
rs1283413669 1500 dbSNP
rs1398806224 1509 dbSNP
rs1340472005 1510 dbSNP
rs1316782695 1511 dbSNP
rs79900076 1512 dbSNP
rs1231979470 1514 dbSNP
rs200873530 1515 dbSNP
rs760292174 1516 dbSNP
rs1464769405 1517 dbSNP
rs774973573 1518 dbSNP
rs1171543217 1520 dbSNP
rs1399402184 1523 dbSNP
rs771805856 1524 dbSNP
rs1477504969 1525 dbSNP
rs1334356973 1526 dbSNP
rs368350946 1531 dbSNP
rs376262095 1532 dbSNP
rs1447496484 1533 dbSNP
rs1280022716 1536 dbSNP
rs202174311 1538 dbSNP
rs1198481698 1543 dbSNP
rs1342923684 1544 dbSNP
rs1325282392 1551 dbSNP
rs143590565 1552 dbSNP
rs780121313 1553 dbSNP
rs1279543453 1554 dbSNP
rs1488168727 1556 dbSNP
rs1315602112 1560 dbSNP
rs138005647 1561 dbSNP
rs1265774885 1563 dbSNP
rs1488929937 1567 dbSNP
rs1198737641 1568 dbSNP
rs1433560444 1569 dbSNP
rs750207148 1573 dbSNP
rs199910418 1574 dbSNP
rs1478696430 1582 dbSNP
rs757202616 1585 dbSNP
rs1437118491 1587 dbSNP
rs1172812835 1588 dbSNP
rs1450854541 1592 dbSNP
rs753814408 1594 dbSNP
rs764131821 1600 dbSNP
rs563399305 1602 dbSNP
rs1417529347 1607 dbSNP
rs1169697479 1608 dbSNP
rs1417479247 1611 dbSNP
rs752273514 1617 dbSNP
rs775617205 1621 dbSNP
rs1185169448 1626 dbSNP
rs1056289171 1629 dbSNP
rs944302221 1631 dbSNP
rs937961494 1633 dbSNP
rs1329444222 1639 dbSNP
rs1235443436 1640 dbSNP
rs1304245871 1648 dbSNP
rs1353327834 1664 dbSNP
rs1238216614 1670 dbSNP
rs912795656 1673 dbSNP
rs550054398 1676 dbSNP
rs1209790052 1682 dbSNP
rs529820004 1683 dbSNP
rs930261674 1684 dbSNP
rs929595696 1688 dbSNP
rs1199038488 1690 dbSNP
rs919709120 1694 dbSNP
rs1447783962 1695 dbSNP
rs1357585354 1698 dbSNP
rs1269797733 1700 dbSNP
rs1160054964 1706 dbSNP
rs919023692 1709 dbSNP
rs974225892 1720 dbSNP
rs1161408914 1721 dbSNP
rs971783927 1724 dbSNP
rs1328426636 1729 dbSNP
rs73285814 1741 dbSNP
rs541259955 1742 dbSNP
rs1364923848 1749 dbSNP
rs32955 1752 dbSNP
rs991976729 1768 dbSNP
rs755843926 1774 dbSNP
rs1346534916 1777 dbSNP
rs954479405 1778 dbSNP
rs1244434783 1780 dbSNP
rs1264046313 1781 dbSNP
rs1028533317 1782 dbSNP
rs1359147231 1783 dbSNP
rs1256916581 1785 dbSNP
rs78820103 1791 dbSNP
rs1180150611 1792 dbSNP
rs1462440517 1797 dbSNP
rs1238352040 1803 dbSNP
rs1243380116 1807 dbSNP
rs1427368785 1809 dbSNP
rs1197689606 1812 dbSNP
rs759190176 1814 dbSNP
rs56017834 1815 dbSNP
rs773503771 1824 dbSNP
rs770128553 1825 dbSNP
rs1340713926 1826 dbSNP
rs1284067112 1833 dbSNP
rs1369951695 1835 dbSNP
rs1458381562 1838 dbSNP
rs762229943 1845 dbSNP
rs748083136 1847 dbSNP
rs148911284 1854 dbSNP
rs774298715 1855 dbSNP
rs1464075082 1856 dbSNP
rs1333622066 1860 dbSNP
rs1352945521 1863 dbSNP
rs374920239 1867 dbSNP
rs1030834911 1870 dbSNP
rs769257857 1882 dbSNP
rs747016028 1883 dbSNP
rs780217003 1886 dbSNP
rs145547239 1888 dbSNP
rs746101960 1889 dbSNP
rs150312997 1891 dbSNP
rs757114672 1893 dbSNP
rs201219952 1902 dbSNP
rs1349933420 1905 dbSNP
rs756107881 1908 dbSNP
rs370251427 1909 dbSNP
rs139840036 1910 dbSNP
rs768369208 1910 dbSNP
rs1330991565 1915 dbSNP
rs146456008 1918 dbSNP
rs751205892 1919 dbSNP
rs766056651 1924 dbSNP
rs144069501 1925 dbSNP
rs1316214940 1928 dbSNP
rs777079548 1937 dbSNP
rs139014914 1942 dbSNP
rs761252999 1943 dbSNP
rs1443025210 1944 dbSNP
rs778742907 1950 dbSNP
rs150727860 1952 dbSNP
rs14251 1955 dbSNP
rs1426519901 1957 dbSNP
rs1355166616 1961 dbSNP
rs749046772 1965 dbSNP
rs17855845 1970 dbSNP
rs1157851924 1971 dbSNP
rs1465768037 1972 dbSNP
rs987376013 1983 dbSNP
rs891391205 1986 dbSNP
rs779865975 1995 dbSNP
rs954202547 1997 dbSNP
rs755893549 1998 dbSNP
rs746013868 1999 dbSNP
rs1047337508 2000 dbSNP
rs1177495515 2002 dbSNP
rs1477486373 2003 dbSNP
rs113111824 2006 dbSNP
rs531905510 2007 dbSNP
rs148592125 2010 dbSNP
rs919572805 2016 dbSNP
rs554721773 2017 dbSNP
rs374582822 2022 dbSNP
rs748099162 2023 dbSNP
rs1224593066 2026 dbSNP
rs1257332972 2033 dbSNP
rs781056296 2035 dbSNP
rs534935746 2036 dbSNP
rs140243622 2042 dbSNP
rs1215711011 2043 dbSNP
rs1406796226 2046 dbSNP
rs751122042 2048 dbSNP
rs1172460579 2059 dbSNP
rs765970520 2061 dbSNP
rs1187005758 2064 dbSNP
rs1428550123 2066 dbSNP
rs758082791 2069 dbSNP
rs961080318 2073 dbSNP
rs1035078373 2075 dbSNP
rs992402016 2079 dbSNP
rs552652553 2099 dbSNP
rs1002461059 2100 dbSNP
rs1410552956 2102 dbSNP
rs1392073465 2103 dbSNP
rs905001461 2107 dbSNP
rs563233016 2108 dbSNP
rs1435572394 2112 dbSNP
rs1358985785 2116 dbSNP
rs1402428697 2124 dbSNP
rs1186947339 2132 dbSNP
rs867854274 2133 dbSNP
rs994784103 2136 dbSNP
rs1366305613 2137 dbSNP
rs183917220 2145 dbSNP
rs1036067166 2146 dbSNP
rs1302760079 2147 dbSNP
rs977962348 2155 dbSNP
rs1238946940 2160 dbSNP
rs757340034 2176 dbSNP
rs1022060011 2184 dbSNP
rs570051558 2190 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gacacCCCCGUC-----CUCCCCGc 5'
               || | ||     ||||||| 
Target 5' --gaaGGAGAAGAGACUGAGGGGCu 3'
1 - 23
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000435817.2 | 3UTR | GAAGGAGAAGAGACUGAGGGGCUGUGACCUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
63 hsa-miR-4749-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT082256 MED29 mediator complex subunit 29 2 4
MIRT112161 OTUD3 OTU deubiquitinase 3 2 2
MIRT150036 MIDN midnolin 2 2
MIRT246308 HIST2H2AA3 histone cluster 2 H2A family member a3 2 4
MIRT246320 HIST2H2AA4 histone cluster 2 H2A family member a4 2 4
MIRT248254 SP1 Sp1 transcription factor 2 2
MIRT257944 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT466973 STARD7 StAR related lipid transfer domain containing 7 2 4
MIRT492322 SETD1B SET domain containing 1B 2 2
MIRT496204 EFCAB1 EF-hand calcium binding domain 1 2 2
MIRT497568 CCR6 C-C motif chemokine receptor 6 2 2
MIRT502990 CCDC71L coiled-coil domain containing 71 like 2 8
MIRT508300 SIX5 SIX homeobox 5 2 4
MIRT522472 ZAK mitogen-activated protein kinase kinase kinase 20 2 2
MIRT525825 VIMP selenoprotein S 2 4
MIRT528154 BCL2L1 BCL2 like 1 2 2
MIRT532606 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT551302 RPRM reprimo, TP53 dependent G2 arrest mediator homolog 2 2
MIRT568777 FAM53C family with sequence similarity 53 member C 2 6
MIRT570896 METTL21A methyltransferase like 21A 2 2
MIRT570963 TMBIM4 transmembrane BAX inhibitor motif containing 4 2 2
MIRT571167 ZNF85 zinc finger protein 85 2 2
MIRT576751 Tmem127 transmembrane protein 127 2 2
MIRT609854 DAZAP2 DAZ associated protein 2 2 2
MIRT627101 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT637060 PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 2 2
MIRT639423 PKP1 plakophilin 1 2 2
MIRT643208 TYW3 tRNA-yW synthesizing protein 3 homolog 2 4
MIRT646251 PRSS38 protease, serine 38 2 2
MIRT647145 CYP27C1 cytochrome P450 family 27 subfamily C member 1 2 2
MIRT647429 ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2 2
MIRT650666 GAPDHP44 glyceraldehyde 3 phosphate dehydrogenase pseudogene 44 2 2
MIRT651816 USP49 ubiquitin specific peptidase 49 2 2
MIRT657376 HMGA1 high mobility group AT-hook 1 2 2
MIRT658105 FOXK1 forkhead box K1 2 2
MIRT658161 FCHSD1 FCH and double SH3 domains 1 2 2
MIRT662754 LRRC3C leucine rich repeat containing 3C 2 2
MIRT667209 NIPAL1 NIPA like domain containing 1 2 2
MIRT687003 RPL35 ribosomal protein L35 2 2
MIRT707057 NACC2 NACC family member 2 2 2
MIRT709048 MRO maestro 2 2
MIRT709054 MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B 2 2
MIRT709446 VWA2 von Willebrand factor A domain containing 2 2 2
MIRT709847 SNX12 sorting nexin 12 2 2
MIRT710790 IFNLR1 interferon lambda receptor 1 2 2
MIRT711696 GMPR guanosine monophosphate reductase 2 2
MIRT712462 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT713884 MOB3A MOB kinase activator 3A 2 2
MIRT715329 NTN1 netrin 1 2 2
MIRT715927 CHD4 chromodomain helicase DNA binding protein 4 2 2
MIRT716533 ATF5 activating transcription factor 5 2 2
MIRT716937 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT717007 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT719139 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT720853 MEF2D myocyte enhancer factor 2D 2 2
MIRT721484 LTB4R2 leukotriene B4 receptor 2 2 2
MIRT721517 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT722895 LRRC20 leucine rich repeat containing 20 2 2
MIRT723066 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723086 INSIG1 insulin induced gene 1 2 2
MIRT723353 ASCL2 achaete-scute family bHLH transcription factor 2 2 2
MIRT723483 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT724576 NOTCH2 notch 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4749 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4749 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4749 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4749-3p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4749-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (TOV-112D)

Error report submission