miRTarBase - #MIRT658718


—
pre-miRNA Information
pre-miRNA hsa-mir-2115   
Genomic Coordinates chr3: 48316360 - 48316459
Description Homo sapiens miR-2115 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2115-3p
Sequence 58| CAUCAGAAUUCAUGGAGGCUAG |79
Evidence Experimental
Experiments 454
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31490809 22 COSMIC
COSN31579735 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs543123304 18 dbSNP
rs1450988157 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ELN   
Synonyms ADCL1, SVAS, WBS, WS
Description elastin
Transcript NM_000501   
Other Transcripts NM_001081752 , NM_001081753 , NM_001081754 , NM_001081755   
Expression
Putative miRNA Targets on ELN
3'UTR of ELN
(miRNA target sites are highlighted)		 
>ELN|NM_000501|3'UTR
   1 GCTTCCTAGGACCCCTGACTCACGACCTCATCAACGTTGGTGCTACTGCTTGGTGGAGAATGTAAACCCTTTGTAACCCC
  81 ATCCCATGCCCCTCCGACTCCCCACCCCAGGAGGGAACGGGCAGGCCGGGCGGCCTTGCAGATCCACAGGGCAAGGAAAC
 161 AAGAGGGGAGCGGCCAAGTGCCCCGACCAGGAGGCCCCCTACTTCAGAGGCAAGGGCCATGTGGTCCTGGCCCCCCACCC
 241 CATCCCTTCCCACCTAGGAGCTCCCCCTCCACACAGCCTCCATCTCCAGGGGAACTTGGTGCTACACGCTGGTGCTCTTA
 321 TCTTCCTGGGGGGAGGGAGGAGGGAAGGGTGGCCCCTCGGGGAACCCCCTACCTGGGGCTCCTCTAAAGATGGTGCAGAC
 401 ACTTCCTGGGCAGTCCCAGCTCCCCCTGCCCACCAGGACCCACCGTTGGCTGCCATCCAGTTGGTACCCAAGCACCTGAA
 481 GCCTCAAAGCTGGATTCGCTCTAGCATCCCTCCTCTCCTGGGTCCACTTGGCCGTCTCCTCCCCACCGATCGCTGTTCCC
 561 CACATCTGGGGCGCTTTTGGGTTGGAAAACCACCCCACACTGGGAATAGCCACCTTGCCCTTGTAGAATCCATCCGCCCA
 641 TCCGTCCATTCATCCATCGGTCCGTCCATCCATGTCCCCAGTTGACCGCCCGGCACCACTAGCTGGCTGGGTGCACCCAC
 721 CATCAACCTGGTTGACCTGTCATGGCCGCCTGTGCCCTGCCTCCACCCCCATCCTACACTCCCCCAGGGCGTGCGGGGCT
 801 GTGCAGACTGGGGTGCCAGGCATCTCCTCCCCACCCGGGGTGTCCCCACATGCAGTACTGTATACCCCCCATCCCTCCCT
 881 CGGTCCACTGAACTTCAGAGCAGTTCCCATTCCTGCCCCGCCCATCTTTTTGTGTCTCGCTGTGATAGATCAATAAATAT
 961 TTTATTTTTTGTCCTGGATATTTGGGGATTATTTTTGATTGTTGATATTCTCTTTTGGTTTTATTGTTGTGGTTCATTGA
1041 AAAAAAAAGATAATTTTTTTTTCTGATCCGGGGAGCTGTATCCCCAGTAGAAAAAACATTTTAATCACTCTAATATAACT
1121 CTGGATGAAACACACCTTTTTTTTTAATAAGAAAAGAGAATTAACTGCTTCAGAAATGACTAATAAATGAAAAACCTTTA
1201 AAGGAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaUCGGAGGUACUUAAGACUAc 5'
            | ::|:: |   ||||||| 
Target 5' atAATTTTTTT---TTCTGATc 3'
 1050 - 1068 141.00 -5.70
2 
miRNA  3' gaucggAGGU-ACUU-AAGACUac 5'
                |||| |||| ||| ||  
Target 5' cctcggTCCACTGAACTTCAGAgc 3'
 878 - 901 112.00 -7.70
3 
miRNA  3' gaUCGGAGGUACUUAAGACUac 5'
            || | || | | ||| ||  
Target 5' ggAGGCCCCCT-ACTTCAGAgg 3'
 190 - 210 103.00 -6.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
360663 96 ClinVar
908408 103 ClinVar
908409 172 ClinVar
360664 173 ClinVar
360665 239 ClinVar
360666 252 ClinVar
909257 265 ClinVar
909258 359 ClinVar
360667 384 ClinVar
360668 430 ClinVar
360669 459 ClinVar
360670 490 ClinVar
360671 502 ClinVar
911255 533 ClinVar
360672 549 ClinVar
360673 563 ClinVar
360674 571 ClinVar
908475 579 ClinVar
908476 592 ClinVar
360675 630 ClinVar
908477 632 ClinVar
360676 637 ClinVar
909327 645 ClinVar
360677 660 ClinVar
360678 664 ClinVar
910296 665 ClinVar
360679 795 ClinVar
360680 998 ClinVar
360681 1054 ClinVar
360682 1137 ClinVar
360683 1195 ClinVar
360684 1196 ClinVar
COSN30480973 11 COSMIC
COSN31512683 19 COSMIC
COSN20120738 20 COSMIC
COSN30146923 22 COSMIC
COSN30492076 28 COSMIC
COSN31551747 28 COSMIC
COSN30106306 33 COSMIC
COSN31543048 79 COSMIC
COSN28854896 96 COSMIC
COSN31495939 96 COSMIC
COSN30485955 102 COSMIC
COSN30485949 103 COSMIC
COSN30462149 114 COSMIC
COSN30485134 115 COSMIC
COSN31519584 118 COSMIC
COSN30118067 119 COSMIC
COSN30503337 123 COSMIC
COSN24374578 133 COSMIC
COSN508072 145 COSMIC
COSN30132339 148 COSMIC
COSN30105541 191 COSMIC
COSN30469667 210 COSMIC
COSN30745011 224 COSMIC
COSN30503380 251 COSMIC
COSN1353464 312 COSMIC
COSN31549958 318 COSMIC
COSN29930579 398 COSMIC
COSN25861917 446 COSMIC
COSN31541142 473 COSMIC
COSN8517627 483 COSMIC
COSN31539363 499 COSMIC
COSN20104343 502 COSMIC
COSN17181967 589 COSMIC
COSN29504034 603 COSMIC
COSN8307442 609 COSMIC
COSN31481839 644 COSMIC
COSN8307443 645 COSMIC
COSN26556878 714 COSMIC
COSN26603886 780 COSMIC
COSN31585892 957 COSMIC
COSN32062135 1146 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1487649993 3 dbSNP
rs11768231 7 dbSNP
rs782307877 11 dbSNP
rs782792718 14 dbSNP
rs782686799 15 dbSNP
rs1261675400 17 dbSNP
rs377353160 24 dbSNP
rs572506935 25 dbSNP
rs1003063715 33 dbSNP
rs781974917 36 dbSNP
rs370665836 37 dbSNP
rs375696064 45 dbSNP
rs1279029507 46 dbSNP
rs781924310 47 dbSNP
rs782169905 49 dbSNP
rs914657702 51 dbSNP
rs967355706 79 dbSNP
rs575495469 81 dbSNP
rs1397774694 88 dbSNP
rs181078432 96 dbSNP
rs912497477 97 dbSNP
rs1464325009 103 dbSNP
rs1402055724 104 dbSNP
rs1170879322 106 dbSNP
rs573898491 108 dbSNP
rs1477214426 120 dbSNP
rs1420921912 126 dbSNP
rs1189001951 128 dbSNP
rs943981290 129 dbSNP
rs1256027685 132 dbSNP
rs544374170 133 dbSNP
rs1459332323 136 dbSNP
rs1258962304 151 dbSNP
rs1039608276 152 dbSNP
rs568047681 165 dbSNP
rs782696069 168 dbSNP
rs781941957 172 dbSNP
rs56120764 173 dbSNP
rs1450204265 185 dbSNP
rs774047388 186 dbSNP
rs1331789386 187 dbSNP
rs1464827966 195 dbSNP
rs1397644519 200 dbSNP
rs782146535 210 dbSNP
rs1457930904 217 dbSNP
rs1368421244 220 dbSNP
rs782819632 223 dbSNP
rs1441933913 227 dbSNP
rs543784994 231 dbSNP
rs1046076703 237 dbSNP
rs546341976 239 dbSNP
rs1243776420 245 dbSNP
rs886062430 252 dbSNP
rs11768314 255 dbSNP
rs564427976 261 dbSNP
rs1309771565 265 dbSNP
rs1445725512 267 dbSNP
rs1333648651 272 dbSNP
rs1325057850 275 dbSNP
rs1386856809 283 dbSNP
rs1389300922 291 dbSNP
rs1161127379 308 dbSNP
rs1003566132 309 dbSNP
rs1381441815 323 dbSNP
rs1158451564 329 dbSNP
rs1438170372 330 dbSNP
rs1199774351 337 dbSNP
rs781869990 339 dbSNP
rs1034599176 349 dbSNP
rs1265434687 353 dbSNP
rs1218854967 357 dbSNP
rs1489252176 359 dbSNP
rs761538157 360 dbSNP
rs1011708013 369 dbSNP
rs1239181180 370 dbSNP
rs1348204421 379 dbSNP
rs528497233 382 dbSNP
rs184490734 384 dbSNP
rs568736593 409 dbSNP
rs967411293 412 dbSNP
rs1233603458 418 dbSNP
rs1330134190 419 dbSNP
rs868928478 427 dbSNP
rs62476387 430 dbSNP
rs912590857 432 dbSNP
rs189306738 445 dbSNP
rs975773272 446 dbSNP
rs1298064071 454 dbSNP
rs921150441 455 dbSNP
rs886062431 459 dbSNP
rs1399330109 460 dbSNP
rs1427780413 461 dbSNP
rs931145169 466 dbSNP
rs1048231378 475 dbSNP
rs1477849133 477 dbSNP
rs886062432 490 dbSNP
rs1195967200 498 dbSNP
rs908312383 499 dbSNP
rs1215723980 502 dbSNP
rs1445203754 502 dbSNP
rs34208922 502 dbSNP
rs1280540366 514 dbSNP
rs1200790729 532 dbSNP
rs939778506 533 dbSNP
rs782742217 534 dbSNP
rs1280918066 535 dbSNP
rs181973759 538 dbSNP
rs1340529872 540 dbSNP
rs1277019546 548 dbSNP
rs117454480 549 dbSNP
rs906232911 553 dbSNP
rs539096901 563 dbSNP
rs1404210873 570 dbSNP
rs565400803 571 dbSNP
rs766250722 573 dbSNP
rs1423087592 574 dbSNP
rs1184841794 578 dbSNP
rs1474413551 582 dbSNP
rs1239091614 586 dbSNP
rs1188025186 587 dbSNP
rs1441577184 590 dbSNP
rs782460313 592 dbSNP
rs1200217048 594 dbSNP
rs1318153106 599 dbSNP
rs1012176845 602 dbSNP
rs782654101 605 dbSNP
rs1212262355 608 dbSNP
rs1382000758 612 dbSNP
rs1285248507 613 dbSNP
rs1021771167 615 dbSNP
rs1380951560 619 dbSNP
rs1333781052 620 dbSNP
rs1466389457 624 dbSNP
rs776424755 630 dbSNP
rs1168466814 632 dbSNP
rs557439074 635 dbSNP
rs566270076 636 dbSNP
rs533779578 637 dbSNP
rs1415894108 640 dbSNP
rs1019652109 644 dbSNP
rs759507028 645 dbSNP
rs975404753 646 dbSNP
rs1180256263 649 dbSNP
rs1457968173 654 dbSNP
rs555096630 659 dbSNP
rs8326 660 dbSNP
rs149644057 661 dbSNP
rs886062433 664 dbSNP
rs952638605 665 dbSNP
rs1311983897 669 dbSNP
rs556367389 673 dbSNP
rs577916788 674 dbSNP
rs368289658 678 dbSNP
rs984022442 679 dbSNP
rs908407280 688 dbSNP
rs564564089 689 dbSNP
rs1322960818 692 dbSNP
rs1423996275 693 dbSNP
rs752794929 699 dbSNP
rs1383273609 702 dbSNP
rs1160264418 704 dbSNP
rs1440019398 707 dbSNP
rs573306464 714 dbSNP
rs1406805343 715 dbSNP
rs981898035 723 dbSNP
rs540603127 729 dbSNP
rs782658237 740 dbSNP
rs937683279 748 dbSNP
rs1489254351 753 dbSNP
rs1054773871 756 dbSNP
rs1221062498 767 dbSNP
rs1490014188 773 dbSNP
rs1288720537 788 dbSNP
rs1241345159 790 dbSNP
rs561951325 792 dbSNP
rs185988110 795 dbSNP
rs1368548304 796 dbSNP
rs947691494 801 dbSNP
rs1043281341 821 dbSNP
rs1299894132 833 dbSNP
rs1344454994 835 dbSNP
rs1420083666 835 dbSNP
rs782221819 836 dbSNP
rs550863560 837 dbSNP
rs903398764 838 dbSNP
rs998938260 840 dbSNP
rs782672945 843 dbSNP
rs1198102092 851 dbSNP
rs1479137963 860 dbSNP
rs1265982082 865 dbSNP
rs1218075029 866 dbSNP
rs1485820889 872 dbSNP
rs1259392361 880 dbSNP
rs781798908 882 dbSNP
rs1212650309 883 dbSNP
rs1282825800 888 dbSNP
rs1221772987 894 dbSNP
rs562701254 895 dbSNP
rs1342371551 897 dbSNP
rs1019663472 901 dbSNP
rs901227406 904 dbSNP
rs1400598383 917 dbSNP
rs1361157081 918 dbSNP
rs1467352583 920 dbSNP
rs1359396364 921 dbSNP
rs1175182962 925 dbSNP
rs782364484 937 dbSNP
rs1425222959 940 dbSNP
rs1428486682 952 dbSNP
rs1260215137 954 dbSNP
rs1183990939 973 dbSNP
rs1483747550 987 dbSNP
rs1262752199 988 dbSNP
rs1202080768 989 dbSNP
rs1320252334 997 dbSNP
rs886062434 998 dbSNP
rs1226741307 1018 dbSNP
rs1325814877 1023 dbSNP
rs1293293518 1033 dbSNP
rs1397567749 1040 dbSNP
rs200584164 1040 dbSNP
rs1335825960 1050 dbSNP
rs1450075490 1051 dbSNP
rs1170812539 1054 dbSNP
rs574934142 1054 dbSNP
rs886062435 1054 dbSNP
rs1461003970 1063 dbSNP
rs1371867237 1069 dbSNP
rs1167439331 1070 dbSNP
rs533339250 1076 dbSNP
rs1242980543 1082 dbSNP
rs1182108414 1083 dbSNP
rs1459289794 1084 dbSNP
rs1238977888 1091 dbSNP
rs1195323029 1092 dbSNP
rs1337455789 1103 dbSNP
rs952811482 1108 dbSNP
rs758577209 1111 dbSNP
rs189177080 1113 dbSNP
rs1015517498 1116 dbSNP
rs1360042775 1120 dbSNP
rs1314165266 1126 dbSNP
rs961202469 1133 dbSNP
rs1243452121 1137 dbSNP
rs1378690927 1137 dbSNP
rs886062436 1137 dbSNP
rs1329051928 1143 dbSNP
rs1390314325 1149 dbSNP
rs1393772599 1151 dbSNP
rs1294757155 1152 dbSNP
rs981908109 1166 dbSNP
rs1458906895 1167 dbSNP
rs535556124 1186 dbSNP
rs1385121505 1193 dbSNP
rs10233395 1195 dbSNP
rs115872030 1196 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000252034.7 | 3UTR | AAAAGAUAAUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC -0.419 0.06 -0.421 0.06 15 Click to see details
HNSC -0.278 0.17 -0.288 0.16 14 Click to see details
BRCA -0.153 0.21 -0.158 0.2 31 Click to see details
LIHC 0.325 0.34 0.800 0.1 4 Click to see details
STAD -0.32 0.4 -0.500 0.33 3 Click to see details
UCEC 0.283 0.41 0.500 0.33 3 Click to see details
BLCA -0.103 0.42 -0.257 0.31 6 Click to see details
BLCA -0.103 0.42 -0.257 0.31 6 Click to see details
BLCA -0.103 0.42 -0.257 0.31 6 Click to see details
BLCA -0.103 0.42 -0.257 0.31 6 Click to see details
BLCA -0.103 0.42 -0.257 0.31 6 Click to see details
BLCA -0.103 0.42 -0.257 0.31 6 Click to see details
BLCA -0.103 0.42 -0.257 0.31 6 Click to see details
80 hsa-miR-2115-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057089 DDIT4 DNA damage inducible transcript 4 2 2
MIRT071216 FCF1 FCF1, rRNA-processing protein 2 2
MIRT226901 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT235961 BACH1 BTB domain and CNC homolog 1 2 2
MIRT294569 ZNF460 zinc finger protein 460 2 4
MIRT321046 RAC1 Rac family small GTPase 1 2 4
MIRT359666 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT366451 KLHL15 kelch like family member 15 2 2
MIRT405375 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT441794 TCEAL5 transcription elongation factor A like 5 2 2
MIRT443295 TCEAL3 transcription elongation factor A like 3 2 2
MIRT455275 DDX39B DExD-box helicase 39B 2 2
MIRT458523 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT464960 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT466848 STX6 syntaxin 6 2 2
MIRT469252 RHOB ras homolog family member B 2 2
MIRT469825 RAB14 RAB14, member RAS oncogene family 2 4
MIRT470047 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT471420 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT472024 NPM1 nucleophosmin 1 2 2
MIRT484156 CENPN centromere protein N 2 2
MIRT485490 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT490462 PROSER2 proline and serine rich 2 2 2
MIRT493069 MTCH1 mitochondrial carrier 1 2 2
MIRT493573 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 8
MIRT494919 NDUFC2-KCTD14 NDUFC2-KCTD14 readthrough 2 2
MIRT500439 ZMAT3 zinc finger matrin-type 3 2 2
MIRT500931 SRPR SRP receptor alpha subunit 2 4
MIRT501551 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501809 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT502415 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT506504 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT507861 CCNE2 cyclin E2 2 2
MIRT510511 YOD1 YOD1 deubiquitinase 2 6
MIRT516073 RAB42 RAB42, member RAS oncogene family 2 2
MIRT519030 KYNU kynureninase 2 6
MIRT521762 PPIL1 peptidylprolyl isomerase like 1 2 4
MIRT522898 KCNJ3 potassium voltage-gated channel subfamily J member 3 2 4
MIRT527370 MGARP mitochondria localized glutamic acid rich protein 2 2
MIRT530691 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT530867 TRUB1 TruB pseudouridine synthase family member 1 2 2
MIRT531832 MTPAP mitochondrial poly(A) polymerase 2 4
MIRT533035 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT533165 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT533464 TRIM71 tripartite motif containing 71 2 2
MIRT534331 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT539372 ADSS adenylosuccinate synthase 2 6
MIRT545951 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT553283 TSR1 TSR1, ribosome maturation factor 2 2
MIRT553532 TMEM185B transmembrane protein 185B 2 4
MIRT556480 LIPA lipase A, lysosomal acid type 2 2
MIRT556975 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT557697 GATA6 GATA binding protein 6 2 2
MIRT558901 CCDC58 coiled-coil domain containing 58 2 2
MIRT559224 BLMH bleomycin hydrolase 2 2
MIRT559827 SLPI secretory leukocyte peptidase inhibitor 2 2
MIRT563435 SLC3A2 solute carrier family 3 member 2 2 2
MIRT569270 PCDH11X protocadherin 11 X-linked 2 2
MIRT571386 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572567 AFF1 AF4/FMR2 family member 1 2 2
MIRT610400 AR androgen receptor 2 2
MIRT611058 ZNF621 zinc finger protein 621 2 2
MIRT635118 TMEM233 transmembrane protein 233 2 2
MIRT641617 DEFB118 defensin beta 118 2 2
MIRT642146 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT647295 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT648155 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT652780 TENM3 teneurin transmembrane protein 3 2 2
MIRT657356 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT658718 ELN elastin 2 2
MIRT662441 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT665302 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT699898 RUNX1 runt related transcription factor 1 2 2
MIRT700921 PDS5A PDS5 cohesin associated factor A 2 2
MIRT700992 PDE3A phosphodiesterase 3A 2 2
MIRT707397 DCAF4L1 DDB1 and CUL4 associated factor 4 like 1 2 2
MIRT711895 INSIG2 insulin induced gene 2 2 2
MIRT712072 XRCC5 X-ray repair cross complementing 5 2 2
MIRT716121 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT724470 SMAD2 SMAD family member 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2115 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-2115 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-2115-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2115-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2115-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

Error report submission