pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SRCAP   
Synonyms DOMO1, EAF1, FLHS, SWR1
Description Snf2 related CREBBP activator protein
Transcript NM_006662   
Expression
Putative miRNA Targets on SRCAP
3'UTR of SRCAP
(miRNA target sites are highlighted)
>SRCAP|NM_006662|3'UTR
   1 GTGGGCTGCCCCTCCACCTAGGCTTTCCACCGTGGCCACTCCCTCCATGACCAGGCCTGACTCTGTTAACCACTACTTGA
  81 AGTCTTGAGGGGGAAAGCCTCCAGGGAGACATAGGGGCCTTCTCCCTTCTTCCCACCAAAGTAGGGGGTAGGCAACTGGT
 161 TGTCATGGAAATGGGGATCATCACAGTCCCCTTCCCCTTCACCCCACGTGGCTGGGCAGTGTTAAGGGTGGCAAGATAGT
 241 CTCTGTCCCCACCCCCTTGTACTTGATTCCCCAGCTGTCTTTCACACAGCCCCCCACCCTTAGGGGAAGGGGGAGGGGCT
 321 TCTCTACAATGAGGTTTTTTTCTTTTTTTTTTTTTTTTAAGAAGAAAAAATAATAAACTTAGTTTCTGTATGAGCAAAAA
 401 AAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cggUUCCCUUAC---CGUCCCUUUa 5'
             ::||||| |    ||||||:| 
Target 5' tgaGGGGGAAAGCCTCCAGGGAGAc 3'
86 - 110 143.00 -20.60
2
miRNA  3' cgGUUCCCUUACCGUCCCUUUa 5'
            |||  |: || || ||||| 
Target 5' ggCAACTGGTTGTCATGGAAAt 3'
151 - 172 132.00 -10.30
3
miRNA  3' cgguucccuuaccGUCCCUUUa 5'
                       :||||:|| 
Target 5' agccccccaccctTAGGGGAAg 3'
288 - 309 125.00 -11.25
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
318924 244 ClinVar
318925 342 ClinVar
318926 343 ClinVar
COSN30096746 118 COSMIC
COSN31492407 175 COSMIC
COSN8497637 299 COSMIC
COSN17037408 332 COSMIC
COSN28087724 350 COSMIC
COSN31533057 351 COSMIC
COSN30538549 360 COSMIC
COSN31489109 362 COSMIC
COSN15157296 742 COSMIC
COSN9645498 834 COSMIC
COSN15848948 972 COSMIC
COSN17819902 1356 COSMIC
COSN5406409 1443 COSMIC
COSN5406410 1466 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs776557423 2 dbSNP
rs920827090 7 dbSNP
rs929481204 10 dbSNP
rs1181472367 11 dbSNP
rs1047899710 12 dbSNP
rs761359958 13 dbSNP
rs1421787558 15 dbSNP
rs764991569 16 dbSNP
rs376319548 23 dbSNP
rs1263045695 24 dbSNP
rs1451790192 30 dbSNP
rs763403768 32 dbSNP
rs142064048 33 dbSNP
rs990098300 36 dbSNP
rs1039127322 37 dbSNP
rs1220379641 38 dbSNP
rs368747756 39 dbSNP
rs1430339222 40 dbSNP
rs764402414 44 dbSNP
rs192066047 48 dbSNP
rs977267255 49 dbSNP
rs1403890918 50 dbSNP
rs1054394963 52 dbSNP
rs891678537 55 dbSNP
rs1010032406 57 dbSNP
rs1185651516 58 dbSNP
rs572979591 61 dbSNP
rs991137929 62 dbSNP
rs1185408688 64 dbSNP
rs1024051979 71 dbSNP
rs1478163895 73 dbSNP
rs971200508 80 dbSNP
rs1219113443 83 dbSNP
rs147764660 84 dbSNP
rs1034502093 89 dbSNP
rs1367429040 92 dbSNP
rs1315963175 93 dbSNP
rs1256266768 97 dbSNP
rs1461474763 103 dbSNP
rs1276775042 111 dbSNP
rs931563363 123 dbSNP
rs1166677030 125 dbSNP
rs1332420642 126 dbSNP
rs1467684677 126 dbSNP
rs1048650217 127 dbSNP
rs908702653 130 dbSNP
rs1414474911 139 dbSNP
rs1289883441 147 dbSNP
rs867682530 148 dbSNP
rs1041214888 151 dbSNP
rs901216188 154 dbSNP
rs997346786 162 dbSNP
rs1360492686 165 dbSNP
rs962429511 180 dbSNP
rs546713293 183 dbSNP
rs920872056 184 dbSNP
rs1180223095 194 dbSNP
rs1312595661 196 dbSNP
rs950913857 201 dbSNP
rs1257274216 204 dbSNP
rs1203933634 207 dbSNP
rs983623495 209 dbSNP
rs1280818929 210 dbSNP
rs1217728502 219 dbSNP
rs912104979 237 dbSNP
rs1235153595 238 dbSNP
rs1310475676 240 dbSNP
rs577624873 244 dbSNP
rs1011489319 245 dbSNP
rs1298046581 252 dbSNP
rs544993543 253 dbSNP
rs1360430515 259 dbSNP
rs1328825607 270 dbSNP
rs1380492403 275 dbSNP
rs1039141034 283 dbSNP
rs921985739 287 dbSNP
rs936026831 288 dbSNP
rs1054830183 290 dbSNP
rs1486708879 290 dbSNP
rs891713447 293 dbSNP
rs1003588420 297 dbSNP
rs562943440 299 dbSNP
rs998651359 300 dbSNP
rs1198695191 303 dbSNP
rs1286925826 307 dbSNP
rs1035941832 311 dbSNP
rs1010147301 327 dbSNP
rs1256663227 328 dbSNP
rs1306701526 329 dbSNP
rs1229446333 335 dbSNP
rs1475254932 335 dbSNP
rs1300601189 338 dbSNP
rs530755836 339 dbSNP
rs1360786556 341 dbSNP
rs1409118873 342 dbSNP
rs886051909 342 dbSNP
rs1035511782 343 dbSNP
rs1185902855 343 dbSNP
rs1221287930 343 dbSNP
rs1411482285 343 dbSNP
rs1417475585 343 dbSNP
rs1474887554 343 dbSNP
rs397854666 343 dbSNP
rs1472091329 344 dbSNP
rs991687911 347 dbSNP
rs1485004190 348 dbSNP
rs1159350934 351 dbSNP
rs1260528421 352 dbSNP
rs1365953253 353 dbSNP
rs915561349 356 dbSNP
rs1233199795 359 dbSNP
rs1279502351 359 dbSNP
rs1291918525 359 dbSNP
rs1340670699 359 dbSNP
rs1397800780 360 dbSNP
rs1383730204 379 dbSNP
rs1293923284 381 dbSNP
rs1464821035 387 dbSNP
rs907075225 400 dbSNP
rs1001305949 402 dbSNP
rs1164195403 409 dbSNP
rs1478103703 411 dbSNP
rs1424486075 415 dbSNP
rs983763438 416 dbSNP
rs1426995091 423 dbSNP
rs1261221121 428 dbSNP
rs1034121687 435 dbSNP
rs1302797507 435 dbSNP
rs962749711 439 dbSNP
rs1489707479 448 dbSNP
rs995192843 450 dbSNP
rs1213660495 452 dbSNP
rs756527660 453 dbSNP
rs1224556978 456 dbSNP
rs951026057 459 dbSNP
rs781512302 460 dbSNP
rs780533954 465 dbSNP
rs1301465381 467 dbSNP
rs1388137197 473 dbSNP
rs1365308834 475 dbSNP
rs1324948789 478 dbSNP
rs1466099528 479 dbSNP
rs1306323833 480 dbSNP
rs940278442 481 dbSNP
rs1349926436 487 dbSNP
rs548851878 492 dbSNP
rs1224585291 495 dbSNP
rs983731699 496 dbSNP
rs912127807 497 dbSNP
rs1177147912 507 dbSNP
rs1041182499 520 dbSNP
rs1251572879 534 dbSNP
rs1193338924 536 dbSNP
rs1458627308 536 dbSNP
rs1240494710 537 dbSNP
rs922793934 538 dbSNP
rs141458112 542 dbSNP
rs932747376 547 dbSNP
rs975284786 548 dbSNP
rs147006778 553 dbSNP
rs893911110 557 dbSNP
rs750439577 559 dbSNP
rs1279524141 560 dbSNP
rs1326843690 562 dbSNP
rs1485994219 563 dbSNP
rs1395916011 566 dbSNP
rs1010889927 570 dbSNP
rs1467792074 571 dbSNP
rs936043967 576 dbSNP
rs1347394128 583 dbSNP
rs770233425 585 dbSNP
rs1393455237 589 dbSNP
rs1042417836 590 dbSNP
rs1173407041 592 dbSNP
rs1249045313 607 dbSNP
rs903069658 612 dbSNP
rs1177456162 614 dbSNP
rs546440500 615 dbSNP
rs1431815446 616 dbSNP
rs1256271791 627 dbSNP
rs990247754 628 dbSNP
rs1201633355 631 dbSNP
rs913268128 634 dbSNP
rs183818756 639 dbSNP
rs756202931 640 dbSNP
rs138139662 641 dbSNP
rs1437178820 642 dbSNP
rs1277528136 643 dbSNP
rs1238307040 650 dbSNP
rs1340936328 651 dbSNP
rs960169506 652 dbSNP
rs1012656442 653 dbSNP
rs1312560397 659 dbSNP
rs1288458785 660 dbSNP
rs1362886538 673 dbSNP
rs1157169442 679 dbSNP
rs1370067531 680 dbSNP
rs937203554 681 dbSNP
rs1442964937 682 dbSNP
rs1488627297 691 dbSNP
rs1023107831 705 dbSNP
rs1189035263 710 dbSNP
rs952482124 711 dbSNP
rs1256193332 719 dbSNP
rs1489055832 722 dbSNP
rs1056002598 729 dbSNP
rs983712363 732 dbSNP
rs1015220200 735 dbSNP
rs898250234 738 dbSNP
rs1215166747 741 dbSNP
rs79825013 742 dbSNP
rs1204283250 743 dbSNP
rs1300132702 746 dbSNP
rs1356963864 749 dbSNP
rs995704201 765 dbSNP
rs1386417177 767 dbSNP
rs749291849 768 dbSNP
rs768222606 772 dbSNP
rs1353715156 773 dbSNP
rs922774033 775 dbSNP
rs754993208 776 dbSNP
rs985667060 776 dbSNP
rs915292376 785 dbSNP
rs946792538 786 dbSNP
rs1391891878 806 dbSNP
rs1167826689 807 dbSNP
rs551039985 809 dbSNP
rs1302479388 814 dbSNP
rs1348294146 815 dbSNP
rs886796177 817 dbSNP
rs1416593123 818 dbSNP
rs1007871939 820 dbSNP
rs1272335818 825 dbSNP
rs1239934374 833 dbSNP
rs1306437454 837 dbSNP
rs754772444 846 dbSNP
rs1291754281 849 dbSNP
rs778522390 858 dbSNP
rs1234112742 859 dbSNP
rs966248475 860 dbSNP
rs140828389 865 dbSNP
rs1364367604 866 dbSNP
rs1268701768 867 dbSNP
rs1029614645 870 dbSNP
rs1332083788 872 dbSNP
rs957552420 877 dbSNP
rs771555845 882 dbSNP
rs558365012 890 dbSNP
rs946069490 892 dbSNP
rs1187255559 902 dbSNP
rs981380239 908 dbSNP
rs928566114 911 dbSNP
rs1411093759 915 dbSNP
rs1419359535 931 dbSNP
rs1167030246 940 dbSNP
rs1410612335 942 dbSNP
rs576594709 943 dbSNP
rs937218726 943 dbSNP
rs536979252 944 dbSNP
rs1491434293 949 dbSNP
rs1491237356 950 dbSNP
rs1461164449 951 dbSNP
rs1055715240 952 dbSNP
rs1270937183 952 dbSNP
rs898358057 955 dbSNP
rs555279681 957 dbSNP
rs573424611 959 dbSNP
rs1439073985 968 dbSNP
rs977015981 969 dbSNP
rs886827234 971 dbSNP
rs1007904268 972 dbSNP
rs113827466 978 dbSNP
rs1332694583 981 dbSNP
rs1444980662 984 dbSNP
rs1352301398 991 dbSNP
rs1327575740 992 dbSNP
rs1030306873 993 dbSNP
rs1171541129 1000 dbSNP
rs1453636000 1004 dbSNP
rs1380681186 1006 dbSNP
rs954324315 1013 dbSNP
rs772273914 1014 dbSNP
rs1231277754 1019 dbSNP
rs772930291 1024 dbSNP
rs1282662052 1025 dbSNP
rs374661349 1030 dbSNP
rs1347695032 1033 dbSNP
rs915447741 1036 dbSNP
rs946782541 1037 dbSNP
rs561800501 1047 dbSNP
rs1278475014 1052 dbSNP
rs1448052126 1053 dbSNP
rs996864129 1054 dbSNP
rs1029233331 1056 dbSNP
rs923925976 1058 dbSNP
rs939319349 1060 dbSNP
rs773586107 1061 dbSNP
rs1160962581 1068 dbSNP
rs1417280601 1071 dbSNP
rs1176700910 1079 dbSNP
rs1056486996 1083 dbSNP
rs534415389 1085 dbSNP
rs1274564684 1091 dbSNP
rs895683452 1097 dbSNP
rs1209042595 1101 dbSNP
rs558839176 1103 dbSNP
rs115156410 1105 dbSNP
rs990311695 1106 dbSNP
rs1218336803 1109 dbSNP
rs1315661856 1118 dbSNP
rs1212720862 1120 dbSNP
rs1273375131 1124 dbSNP
rs1044198819 1127 dbSNP
rs544696401 1131 dbSNP
rs746501444 1132 dbSNP
rs562980604 1133 dbSNP
rs1340707067 1134 dbSNP
rs1470120745 1139 dbSNP
rs574874533 1140 dbSNP
rs1241883777 1143 dbSNP
rs386790272 1149 dbSNP
rs11150595 1150 dbSNP
rs967401698 1151 dbSNP
rs561249562 1152 dbSNP
rs1420172039 1153 dbSNP
rs928681178 1156 dbSNP
rs958727266 1157 dbSNP
rs991846125 1162 dbSNP
rs896923265 1171 dbSNP
rs113911928 1181 dbSNP
rs931151555 1186 dbSNP
rs1396889904 1196 dbSNP
rs542904793 1200 dbSNP
rs187212114 1205 dbSNP
rs1007182750 1206 dbSNP
rs191966958 1208 dbSNP
rs1316032967 1216 dbSNP
rs763601477 1220 dbSNP
rs1380161915 1222 dbSNP
rs150230181 1223 dbSNP
rs1040808191 1224 dbSNP
rs1443039706 1230 dbSNP
rs1392148444 1233 dbSNP
rs1162883653 1234 dbSNP
rs1460931918 1253 dbSNP
rs960824935 1256 dbSNP
rs916619657 1259 dbSNP
rs1261501431 1262 dbSNP
rs1194615879 1278 dbSNP
rs551078635 1279 dbSNP
rs559174853 1280 dbSNP
rs1376373000 1288 dbSNP
rs1044312538 1301 dbSNP
rs138815841 1302 dbSNP
rs941167037 1306 dbSNP
rs1293538334 1308 dbSNP
rs1306506748 1315 dbSNP
rs1303915865 1317 dbSNP
rs1336585117 1319 dbSNP
rs1206421029 1326 dbSNP
rs996506490 1338 dbSNP
rs896865898 1340 dbSNP
rs764687119 1348 dbSNP
rs893360192 1349 dbSNP
rs530138953 1350 dbSNP
rs548562535 1351 dbSNP
rs1171308449 1354 dbSNP
rs182162636 1354 dbSNP
rs1397364930 1362 dbSNP
rs1447908063 1366 dbSNP
rs1011709261 1379 dbSNP
rs1218592750 1383 dbSNP
rs1372657408 1384 dbSNP
rs1020373063 1387 dbSNP
rs1174675901 1393 dbSNP
rs1455901997 1396 dbSNP
rs1393648656 1399 dbSNP
rs1193600229 1409 dbSNP
rs1438873473 1410 dbSNP
rs997981704 1411 dbSNP
rs774542153 1416 dbSNP
rs1480108321 1424 dbSNP
rs1280527560 1431 dbSNP
rs762247854 1435 dbSNP
rs534223265 1437 dbSNP
rs889483604 1441 dbSNP
rs1002948620 1448 dbSNP
rs1022525752 1449 dbSNP
rs1035725857 1450 dbSNP
rs1471762291 1455 dbSNP
rs1370017395 1472 dbSNP
rs1313793311 1477 dbSNP
rs767581645 1478 dbSNP
rs999655179 1479 dbSNP
rs375428172 1480 dbSNP
rs1173347456 1482 dbSNP
rs1031176283 1484 dbSNP
rs961067227 1491 dbSNP
rs991475069 1492 dbSNP
rs1401029235 1499 dbSNP
rs186851430 1502 dbSNP
rs992294843 1511 dbSNP
rs916549618 1518 dbSNP
rs919843303 1523 dbSNP
rs1484458601 1528 dbSNP
rs1320225225 1531 dbSNP
rs149364337 1532 dbSNP
rs1205436909 1550 dbSNP
rs952617991 1556 dbSNP
rs984767607 1557 dbSNP
rs909766473 1559 dbSNP
rs1293956436 1566 dbSNP
rs941292927 1566 dbSNP
rs982692900 1572 dbSNP
rs1353750539 1577 dbSNP
rs1036819171 1582 dbSNP
rs750702610 1583 dbSNP
rs775542845 1584 dbSNP
rs933717392 1591 dbSNP
rs1050895076 1593 dbSNP
rs538377567 1596 dbSNP
rs1040838715 1598 dbSNP
rs565076239 1601 dbSNP
rs1259366679 1604 dbSNP
rs1204531202 1609 dbSNP
rs1335337837 1614 dbSNP
rs556662049 1617 dbSNP
rs1235139005 1619 dbSNP
rs1332977478 1623 dbSNP
rs1283882288 1625 dbSNP
rs529260222 1628 dbSNP
rs756182412 1629 dbSNP
rs1053423550 1630 dbSNP
rs896673738 1631 dbSNP
rs1351875190 1656 dbSNP
rs1435053483 1658 dbSNP
rs1395773877 1661 dbSNP
rs1014072339 1662 dbSNP
rs1225771861 1663 dbSNP
rs893382319 1665 dbSNP
rs969460302 1671 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgguucccuuaccgUCCCUUUa 5'
                        ||||||| 
Target 5' -----------aaaAGGGAAAa 3'
1 - 11
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000396842.2 | 3UTR | AAAAGGGAAAAAAAAAGCAGGGACUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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