miRTarBase - #MIRT659662


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pre-miRNA Information
pre-miRNA hsa-mir-124-1   
Genomic Coordinates chr8: 9903388 - 9903472
Description Homo sapiens miR-124-1 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-2   
Genomic Coordinates chr8: 64379149 - 64379257
Description Homo sapiens miR-124-2 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-3   
Genomic Coordinates chr20: 63178500 - 63178586
Description Homo sapiens miR-124-3 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-124-5p
Sequence 14| CGUGUUCACAGCGGACCUUGAU |35
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 8 8 + 64379180 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1280076135 1 dbSNP
rs775858016 4 dbSNP
rs760972715 7 dbSNP
rs1334649236 11 dbSNP
rs1160219511 12 dbSNP
rs764591061 12 dbSNP
rs1261326747 13 dbSNP
rs1344491363 20 dbSNP
rs1340798465 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Increase Plasma Polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Peripheral blood mononuclear cell Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol CDC73   
Synonyms C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX
Description cell division cycle 73
Transcript NM_024529   
Expression
Putative miRNA Targets on CDC73
3'UTR of CDC73
(miRNA target sites are highlighted)		 
>CDC73|NM_024529|3'UTR
   1 ATTATTTGGCTCCTCCATTTCTGGAAATTGAGACTCAAGCTTTATGAATTTATCAAGAACTTAAAAATGAAGAAGGTCAC
  81 AGATTGATCTTTTATAAGACCTTATTTGATGCTTTGTGCTTCAAGGAGATGATACCTGTCATCCATATAAGCAAACTTTT
 161 TGGCTTACAACTATTTTTTTAATATTAGCCTTCTAGTCTGTAATGGAAATTGTATATTTTGATAGAAGTTTTTTCTCCAT
 241 TGGTTAAATTAGCATTACTTAAAATTTGTTTCTTTAGAAAATAAATGCAGGTTATAAATGTGTGTATATTTAGAGATTAT
 321 AAGGCTCTCTGAGCCATCTTCTGATTTTTCATTGCTCTATAATTCTTTTTACTGAAAATACTATGTTATGAATGGTATTA
 401 AATTTTAGTCTCTGGAACATCCAAAACCAAGCAAAGGGATGTGACTATTTTGAATGAATCAGAATGTCAACTTGTATGTA
 481 CACTATATCTACACTTACTCATTATTTAAAAAGAATAATGAAAAATCTAGATCAATTCTTCAATTTGATTGAACTGTTCA
 561 GCCTTTTCAAGATTTCTTTATTTACAAATGATTACATTTAAATGAATGTACATTCTTCTCACTGACTTTGGTGATTTTGA
 641 AACCTAGAATGATGTGTTTCTATCTGTAATATCTTTCCATTTGAAAAAAATCTCAAAACACAGATTAAAACCACAATAGG
 721 CTGTAGTATTTTTTATTTTGGGAGCCAGAGTATGATTTGGGGGAAGAATATGTATCAGCCCTATTGCAGTATAACTTTAA
 801 GCTCCTTTTCTCTTTAGTCCACTTTTGATTGTAATTTTTATGGTATAGGATTTTGAATCTTCTATTTTAGGCTTGTCAGT
 881 CTTGGAGTTCTTATCTTCCATTATCCCTAAATATTGATAAACTCCCAGGCACCAAAGAAAACATTTGCTTAATTGTCTGA
 961 AAAGAAACAAGAGAAAAACACTGGTATTTTTATGTCTGTATTCAATATGGTATAAAATATAAAAACTATATTTTAACTTA
1041 GTGAAATATTTTACTATTTCTCTACTTCAGACAAAATGTTGCATCCAAGGTACATCAAGTGACCATTTGCCTTGAACCTT
1121 GATTTCACTTTGTTTTTTTTTTTTCCTTAAAGGCAACTAGGAAGCTTTACTTTCCTAAAGTGTTTTTGCCATTGGAATTT
1201 TTGCTGATCACAGTCTTATGTCATTTTTTTCTCTGTTTTTATTCCCAGCAATTTTCTCCTAGGTTAACATATTTTTGGTG
1281 AACGTTTAGGCCTTTCATAGGTATTAAGCTGACATTATCTAGCTTCTTAATGAAATTTAACACTGTCACAAAAATGAGAA
1361 GTTATTATTTTTTAAGTGATCACATAGTTCATACCACTAGTAACTAGAAAAGATATTTATTCACATGATATTTACAAGGC
1441 TCTTCAGAAGGGAACAGTCAGCATTTTAAATTACTAGATTTTAGCATACTTAACAAGGTTTGAACAGATTCTACCCCTAT
1521 TTTCCTCCCTTTTTAGCGTCTTCTTTCCTTAAAGATAAAAGAAAACTCAAATTTGTTTACATTAGGCTTTCTTAGCATAT
1601 AAATATATTTCCAAAATAAATTACATGTTGTGTAAACTTTCTCCATGATGAAATAGTCAAGGACCAGAATCTGTAATATT
1681 TTTATGTAAGATTACTTGTCAAGACTACTACAAGTCAGTATGAACTACCTTCCCATAAAGATTTTTGGTATTTGTACTTA
1761 TTTATGAACTTTACTTGAGACAGAATATGGTTAAAATTAGGAACATCTACTTTGAATGAGGTTTATTTTTCTATTTTGAA
1841 TTTGCCTTATGTATATTCAAAGGCTTATGGAAATACTGTAAAGGAACATTAGGAAAAGGACAAATAGGCTATAACCATCT
1921 ATCTTAAAATCAGACCCTTAGTATAAGCACCTCTTTTTCTTTTCCTCTTTGACAATTTAGTCTCTTATTTAGGTCCATGT
2001 AATTAATTTCATTCCATTATTTTTTAGCTGTTTATTCTAAAAAACAAAAATTTTCAGCCACTCCCATTTATTCTCCCATG
2081 ACATGGTCCTATATAGCAGTACTTAACACAGTGCCTTGCACATAGTAGGCATTCAGTAAATACTTACATGCATGAATGAA
2161 TAATGTATTTTCAGTGTAACAAATTTATTATAAAAGTGTAGTTCGACTCTTCTTGGTCTTGGAGTTTGAGAGTACAGAAT
2241 TACAGGGAATGAAGAGAGGTATAAGTAGATATTTTAATGGAAATGAAGTATAAATTAATAACTTGACTTACCCCTCCATA
2321 AGTTACTGCTAACTGGAGATACCCTTGTATGCCCAACCTGTAAAGGAAAAAGTTCTATTTCTATATTTATAGGACATTCT
2401 TCTCAGTCAAGGAACAGTAAGAAATATGTAGGTTTCAATCAGTTGCTCTCAACCCTGACTGCATTTTAGAATCATTTGGA
2481 GAGTTTTTAAAAATATCCATGCCTGAATCTTGATTCCCATTTTCATGTAATTTGAGACAAGACCTGGTCATCAGTATTTT
2561 TTTTAAAGTTCTCCAGGTAATTTGAATGTGCAGGAAGGATTCAGAATCACTGGTTTAATTTGTTATTGAAAACAGTACCA
2641 GTATTAAATGTGTTTCCTCTTCCTTCTTTTCTGTATGTATGTGTGGTTTTTGATTTTTTGTTGTTGTTGTTGTTTTGTGG
2721 CCACCCTTTGCACTAGACCATCCCTTTTATTGGTGGTATTGGCCTATATTCCCATTGACAAATGCAATTTTTAATTATTT
2801 ATTTAATATAGGAGTATTTTACTGTTTAATATTTAAACAATGTTTAATGTATTTCATTATTAACTAGTATTATAGTTTGT
2881 TTTTTTCCCATGTCTCCATAACTTTTACTAACATTTGTTTTTAGCAGCACAACAGTAATCCATATAAAAACAACTAATTC
2961 ATAATGAGGAAAATCTCATAATTTTTAAGGCAGAAAGAAGTATTAATTTTTGATCTGCCATGTAGAATGAGACAAATACA
3041 GTTTGCTTATGAAAGGAAAGTGGCATACTTTTAAATTGGTCTACACAGAAAAGTAAAAGTAAACTATTCATTTAAATAAG
3121 ATTCATTATCTAATAAATATTGAGGGAATATTTTTCCTAAATAAAAATTTTTCTGACTGCTAACAAAAATTAAAGTGATT
3201 ACATTGTTCTTTTTTGGAGGGGTGGGGAGGAATATTTGTTGAACTAAAGTATATAAAATTTTTTGAGACTAGCAGTATAT
3281 TTTATAATATTACAAATACAACAATTATTTATAAAAGCTAGTCAAATTAATGGCTTAGAAAGTAGCTGTAAACTTTGTGT
3361 TTTGAAATTGCTTGTTTAAATGCAAAATTATGAGTAAGATAAGTCTTTTTAAATTTTTTATTTTTAATTTTTTTGGAAGT
3441 TTATTAAAGCCCTTCATATACACATACTTTTTAAAAAAAGATTCTTAATAAAGAAATTATTGGTTTGTCTGGTTAAAGTC
3521 CATATAGAATGCTGAGAAATAATTTATAAAATAAGAACTATAGAAATTTGTTCTCAGCTGAAAAGTTGGCAGCTGCTCTG
3601 TTTCTTTAAAAAAGTACAACATGAAAATTTAATTACATTAGCCTTAATATTACTTGACTGAATTTCTACTATTTATTCAC
3681 TTGTGTTTGAGATTCACCCAGCTATTCTAATGATAGAAATAAAAAGTGGAGAAATGACTAAAGTTGACTTAAGTTAAGAA
3761 TTGGAGTGGGAATTTTGAAATGCCATGTCCTATATATTCTGGCATATTTGTTGGCACATTTGCAAGTATGTTGATCCCAG
3841 CATTGTTTATATCTGTTGGAATAATAACTAAGGAAAAATTGAAAATGTATAATAGATGTATAAAGATTTATATTTAGTTA
3921 GTATATAATAGATAATACTTGCAGGTTTTTTATGTGTTTTGGGTTTCTGTGTATTATTTTAGGTAATCTTTATAAGGGCA
4001 TCTTGGAAGTTATAAATATGTGCCATTTACTGAAAAGTGGGAAGCATTTTTATATGAGTAAAGCTAATGAAATAAAACTA
4081 GTTTTATTGCCAAAATTCAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaGUUCCAGGCGACACUUGUgc 5'
            ||||||:     ||||||  
Target 5' aaCAAGGTT-----TGAACAga 3'
 1492 - 1508 135.00 -13.10
2 
miRNA  3' uaGUUCCAGGCGACACUUG-UGc 5'
            ||| ||| | | ||||| || 
Target 5' taCAA-GTCAG-TATGAACTACc 3'
 1709 - 1729 126.00 -7.40
3 
miRNA  3' uaGUUCCAGG------CGAC---ACUUGUGc 5'
            || |||||      || |   | ||||| 
Target 5' gaCATGGTCCTATATAGCAGTACTTAACACa 3'
 2080 - 2110 122.00 -10.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
221109 13 ClinVar
294416 95 ClinVar
873578 245 ClinVar
874579 299 ClinVar
294417 454 ClinVar
294418 464 ClinVar
294419 519 ClinVar
294420 581 ClinVar
875503 684 ClinVar
294421 938 ClinVar
876517 949 ClinVar
294422 957 ClinVar
294423 973 ClinVar
294424 1057 ClinVar
294425 1075 ClinVar
294426 1076 ClinVar
294427 1084 ClinVar
294428 1093 ClinVar
294429 1133 ClinVar
294430 1133 ClinVar
875556 1133 ClinVar
294431 1252 ClinVar
294432 1268 ClinVar
876559 1293 ClinVar
873695 1297 ClinVar
294433 1304 ClinVar
294434 1366 ClinVar
873696 1443 ClinVar
294435 1473 ClinVar
294436 1500 ClinVar
875611 1536 ClinVar
294437 1600 ClinVar
875612 1645 ClinVar
876609 1661 ClinVar
294438 1762 ClinVar
294439 1788 ClinVar
873764 1790 ClinVar
873765 1822 ClinVar
294440 1834 ClinVar
294441 1859 ClinVar
294442 1957 ClinVar
294443 1986 ClinVar
294444 2044 ClinVar
294445 2086 ClinVar
294446 2132 ClinVar
294447 2305 ClinVar
294448 2421 ClinVar
294449 2428 ClinVar
294450 2447 ClinVar
294451 2456 ClinVar
874775 2626 ClinVar
874776 2640 ClinVar
294452 2652 ClinVar
294453 2678 ClinVar
876699 2802 ClinVar
294454 2951 ClinVar
294455 2963 ClinVar
294456 2964 ClinVar
294457 2983 ClinVar
873869 3064 ClinVar
294458 3087 ClinVar
294459 3258 ClinVar
294460 3267 ClinVar
875756 3343 ClinVar
294461 3406 ClinVar
294462 3420 ClinVar
294463 3508 ClinVar
294464 3525 ClinVar
294465 3543 ClinVar
294466 3642 ClinVar
873925 3696 ClinVar
294467 3715 ClinVar
874870 3784 ClinVar
294468 3786 ClinVar
294469 3787 ClinVar
294470 3787 ClinVar
294471 3792 ClinVar
294472 3808 ClinVar
875802 3876 ClinVar
875803 3888 ClinVar
COSN19558956 13 COSMIC
COSN31546356 29 COSMIC
COSN30136386 34 COSMIC
COSN31495671 37 COSMIC
COSN5865482 40 COSMIC
COSN30523662 58 COSMIC
COSN20647716 83 COSMIC
COSN31558600 90 COSMIC
COSN1095111 104 COSMIC
COSN31549210 132 COSMIC
COSN19446107 278 COSMIC
COSN31532708 328 COSMIC
COSN16130379 375 COSMIC
COSN31546777 411 COSMIC
COSN31547957 688 COSMIC
COSN31489740 773 COSMIC
COSN26049550 1004 COSMIC
COSN20095696 1145 COSMIC
COSN27273154 1145 COSMIC
COSN15662388 1191 COSMIC
COSN22145049 1293 COSMIC
COSN16993766 1520 COSMIC
COSN24034574 1592 COSMIC
COSN6016307 1675 COSMIC
COSN9024553 2063 COSMIC
COSN22103415 2384 COSMIC
COSN21169557 2756 COSMIC
COSN16555958 2925 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1299986593 8 dbSNP
rs756502131 10 dbSNP
rs200593588 11 dbSNP
rs1329970032 12 dbSNP
rs193025205 13 dbSNP
rs770268430 16 dbSNP
rs758236997 18 dbSNP
rs1041992562 28 dbSNP
rs1320757009 32 dbSNP
rs374812661 35 dbSNP
rs1241902010 39 dbSNP
rs1374057644 40 dbSNP
rs200166430 41 dbSNP
rs137934323 45 dbSNP
rs747134646 53 dbSNP
rs935678386 64 dbSNP
rs1315243053 67 dbSNP
rs1054186955 69 dbSNP
rs1039205401 70 dbSNP
rs1306161199 72 dbSNP
rs1226955411 75 dbSNP
rs1198721073 80 dbSNP
rs1252053693 83 dbSNP
rs1341384430 85 dbSNP
rs1484164250 94 dbSNP
rs547969893 95 dbSNP
rs780435158 96 dbSNP
rs899353781 101 dbSNP
rs899561312 103 dbSNP
rs1256932425 105 dbSNP
rs1294750593 114 dbSNP
rs780001207 120 dbSNP
rs1358128194 128 dbSNP
rs571060685 130 dbSNP
rs1412166616 137 dbSNP
rs540086158 139 dbSNP
rs1464423985 148 dbSNP
rs1420396431 158 dbSNP
rs1188942497 162 dbSNP
rs1029903973 164 dbSNP
rs1026820387 173 dbSNP
rs1235872000 174 dbSNP
rs1184044762 185 dbSNP
rs752740701 189 dbSNP
rs1427764390 195 dbSNP
rs1273658820 203 dbSNP
rs550697956 204 dbSNP
rs1315852244 211 dbSNP
rs1274796293 213 dbSNP
rs1014706292 224 dbSNP
rs1015473735 225 dbSNP
rs1024228801 227 dbSNP
rs1377946245 238 dbSNP
rs1281969160 240 dbSNP
rs1443763245 241 dbSNP
rs1170894668 275 dbSNP
rs969988680 292 dbSNP
rs1432509060 306 dbSNP
rs756127370 308 dbSNP
rs926157467 316 dbSNP
rs1375571849 319 dbSNP
rs1461160623 324 dbSNP
rs1449355313 329 dbSNP
rs961992550 330 dbSNP
rs1470572147 339 dbSNP
rs980026411 355 dbSNP
rs1360293362 356 dbSNP
rs1178005194 357 dbSNP
rs747679189 360 dbSNP
rs771545477 366 dbSNP
rs1320835955 373 dbSNP
rs957433561 376 dbSNP
rs959030964 381 dbSNP
rs556687284 384 dbSNP
rs576486752 391 dbSNP
rs1350785160 392 dbSNP
rs185120002 411 dbSNP
rs1445305452 416 dbSNP
rs1373791377 418 dbSNP
rs971561653 422 dbSNP
rs1212136178 432 dbSNP
rs1436234749 434 dbSNP
rs1348459544 435 dbSNP
rs1320547761 436 dbSNP
rs1240225331 438 dbSNP
rs1379832846 439 dbSNP
rs1156895288 440 dbSNP
rs913005928 442 dbSNP
rs1396834562 447 dbSNP
rs749503658 448 dbSNP
rs1249685338 452 dbSNP
rs547363180 454 dbSNP
rs1447216124 460 dbSNP
rs879039427 464 dbSNP
rs1395153256 475 dbSNP
rs1415735853 476 dbSNP
rs912132280 477 dbSNP
rs112924878 483 dbSNP
rs942968255 486 dbSNP
rs943596405 493 dbSNP
rs1430674911 501 dbSNP
rs1321621892 505 dbSNP
rs1039280384 514 dbSNP
rs920972085 518 dbSNP
rs190433473 519 dbSNP
rs565589424 532 dbSNP
rs1360108375 534 dbSNP
rs1296524825 536 dbSNP
rs930815430 544 dbSNP
rs1047801376 550 dbSNP
rs1303025334 552 dbSNP
rs1422889199 561 dbSNP
rs890925630 571 dbSNP
rs1477972039 573 dbSNP
rs191600804 581 dbSNP
rs1220952107 585 dbSNP
rs1486370108 588 dbSNP
rs746430772 590 dbSNP
rs1280402932 599 dbSNP
rs540968381 600 dbSNP
rs1310927310 607 dbSNP
rs1298250772 611 dbSNP
rs772489155 622 dbSNP
rs776019879 629 dbSNP
rs539729468 630 dbSNP
rs1316217088 638 dbSNP
rs557675611 645 dbSNP
rs1356246154 657 dbSNP
rs1024343240 659 dbSNP
rs1209331032 665 dbSNP
rs577404748 667 dbSNP
rs1357340431 670 dbSNP
rs1028062647 673 dbSNP
rs905879297 684 dbSNP
rs1191082925 690 dbSNP
rs145971830 691 dbSNP
rs1475980219 698 dbSNP
rs1467021185 702 dbSNP
rs1001411513 707 dbSNP
rs958735335 715 dbSNP
rs116580721 717 dbSNP
rs1205751794 724 dbSNP
rs184119278 727 dbSNP
rs1024407158 729 dbSNP
rs1235444911 729 dbSNP
rs971532073 730 dbSNP
rs1335694573 731 dbSNP
rs1312164646 734 dbSNP
rs1168378675 742 dbSNP
rs1375573968 753 dbSNP
rs1010524103 755 dbSNP
rs1020012893 763 dbSNP
rs1399355487 765 dbSNP
rs1160642140 766 dbSNP
rs955328690 767 dbSNP
rs760275535 773 dbSNP
rs1460149421 778 dbSNP
rs986526333 792 dbSNP
rs1325655852 799 dbSNP
rs1366694977 813 dbSNP
rs957848234 814 dbSNP
rs542578210 816 dbSNP
rs768216980 821 dbSNP
rs910864429 844 dbSNP
rs761880826 851 dbSNP
rs963684856 856 dbSNP
rs974933613 858 dbSNP
rs920880998 863 dbSNP
rs930827141 867 dbSNP
rs1215921937 872 dbSNP
rs746726973 876 dbSNP
rs1357442156 882 dbSNP
rs1438902502 889 dbSNP
rs1242796732 891 dbSNP
rs1318830558 899 dbSNP
rs1277830683 906 dbSNP
rs1372743956 907 dbSNP
rs920890936 908 dbSNP
rs559095804 911 dbSNP
rs1240836800 918 dbSNP
rs776494114 920 dbSNP
rs1228924908 924 dbSNP
rs932343365 929 dbSNP
rs1290197628 935 dbSNP
rs1329164134 936 dbSNP
rs886045715 938 dbSNP
rs1332600514 939 dbSNP
rs1391093017 943 dbSNP
rs1212800254 944 dbSNP
rs761544591 949 dbSNP
rs886045716 957 dbSNP
rs1456050756 961 dbSNP
rs866773575 966 dbSNP
rs1452956485 968 dbSNP
rs1202058027 969 dbSNP
rs1365101609 969 dbSNP
rs886045717 973 dbSNP
rs907941373 977 dbSNP
rs950087478 981 dbSNP
rs754552784 983 dbSNP
rs1379029977 984 dbSNP
rs1196005073 987 dbSNP
rs912332249 992 dbSNP
rs1267042655 1006 dbSNP
rs939799509 1008 dbSNP
rs527940893 1010 dbSNP
rs1286890674 1011 dbSNP
rs898364777 1013 dbSNP
rs1351547351 1027 dbSNP
rs1306992040 1031 dbSNP
rs1164598850 1053 dbSNP
rs1391962719 1054 dbSNP
rs1407262013 1055 dbSNP
rs1300325294 1056 dbSNP
rs548106852 1057 dbSNP
rs1001568230 1063 dbSNP
rs1357998075 1065 dbSNP
rs1054375413 1071 dbSNP
rs886045718 1075 dbSNP
rs886045719 1076 dbSNP
rs1410446204 1082 dbSNP
rs1010057583 1083 dbSNP
rs367704451 1084 dbSNP
rs1353436263 1088 dbSNP
rs955253118 1092 dbSNP
rs886045720 1093 dbSNP
rs553620344 1094 dbSNP
rs1282542963 1099 dbSNP
rs1202170101 1100 dbSNP
rs1345588085 1116 dbSNP
rs1007893664 1123 dbSNP
rs1284543196 1128 dbSNP
rs1031840615 1129 dbSNP
rs998973442 1129 dbSNP
rs1342102599 1132 dbSNP
rs1017988008 1133 dbSNP
rs1337853413 1133 dbSNP
rs538761780 1133 dbSNP
rs886045721 1133 dbSNP
rs886045722 1133 dbSNP
rs957564068 1135 dbSNP
rs1358287179 1146 dbSNP
rs1212428405 1147 dbSNP
rs963675077 1148 dbSNP
rs1171294943 1154 dbSNP
rs990775430 1157 dbSNP
rs1424707616 1158 dbSNP
rs1483182267 1163 dbSNP
rs1206628870 1165 dbSNP
rs973750447 1178 dbSNP
rs953821017 1180 dbSNP
rs920839315 1181 dbSNP
rs912261319 1196 dbSNP
rs1369402699 1197 dbSNP
rs1474009520 1204 dbSNP
rs1166528869 1205 dbSNP
rs1319754561 1207 dbSNP
rs1258452207 1213 dbSNP
rs770605135 1214 dbSNP
rs1217711564 1217 dbSNP
rs369311753 1220 dbSNP
rs1285538569 1224 dbSNP
rs972498020 1230 dbSNP
rs1430673603 1232 dbSNP
rs1309912850 1249 dbSNP
rs550417983 1252 dbSNP
rs78218016 1268 dbSNP
rs1414092590 1270 dbSNP
rs1170369357 1272 dbSNP
rs188022876 1272 dbSNP
rs1342210153 1273 dbSNP
rs1045840753 1284 dbSNP
rs1464306342 1284 dbSNP
rs1428304405 1285 dbSNP
rs1472513951 1290 dbSNP
rs1366738173 1291 dbSNP
rs1185406099 1292 dbSNP
rs895043816 1293 dbSNP
rs1269411417 1297 dbSNP
rs949310328 1298 dbSNP
rs886045723 1304 dbSNP
rs1291584115 1324 dbSNP
rs1228479264 1333 dbSNP
rs1355103277 1342 dbSNP
rs766888046 1344 dbSNP
rs927399041 1346 dbSNP
rs937306129 1347 dbSNP
rs1242995913 1360 dbSNP
rs753141268 1362 dbSNP
rs750216508 1365 dbSNP
rs180929933 1366 dbSNP
rs1445071898 1374 dbSNP
rs1351917366 1384 dbSNP
rs1346607879 1387 dbSNP
rs1404973415 1408 dbSNP
rs766239532 1413 dbSNP
rs1160343764 1417 dbSNP
rs893149309 1421 dbSNP
rs751428695 1424 dbSNP
rs1380874193 1425 dbSNP
rs536823753 1430 dbSNP
rs907241628 1432 dbSNP
rs756250069 1436 dbSNP
rs777813437 1446 dbSNP
rs1221928811 1449 dbSNP
rs1450650547 1453 dbSNP
rs558363194 1464 dbSNP
rs890925516 1469 dbSNP
rs576716003 1473 dbSNP
rs1017977988 1475 dbSNP
rs1191430640 1479 dbSNP
rs1238541134 1494 dbSNP
rs1370258083 1498 dbSNP
rs899617410 1499 dbSNP
rs138503809 1500 dbSNP
rs1436078293 1505 dbSNP
rs186077434 1508 dbSNP
rs1031764833 1512 dbSNP
rs1027040001 1518 dbSNP
rs1359915164 1519 dbSNP
rs752646607 1520 dbSNP
rs757392730 1524 dbSNP
rs867185432 1525 dbSNP
rs1427051493 1530 dbSNP
rs1393334253 1534 dbSNP
rs1011765527 1536 dbSNP
rs541013513 1537 dbSNP
rs954310282 1538 dbSNP
rs984072904 1539 dbSNP
rs1015209151 1541 dbSNP
rs1019238426 1542 dbSNP
rs1314426025 1543 dbSNP
rs971551694 1547 dbSNP
rs567042351 1555 dbSNP
rs1219032726 1556 dbSNP
rs557118447 1557 dbSNP
rs1280348507 1563 dbSNP
rs919703138 1579 dbSNP
rs927348128 1580 dbSNP
rs141160842 1583 dbSNP
rs1296385854 1587 dbSNP
rs1451604141 1591 dbSNP
rs1360847631 1597 dbSNP
rs543187347 1598 dbSNP
rs543573271 1600 dbSNP
rs949279879 1606 dbSNP
rs772427151 1615 dbSNP
rs1477940920 1617 dbSNP
rs1261892686 1625 dbSNP
rs1184239502 1626 dbSNP
rs946076807 1629 dbSNP
rs556896257 1644 dbSNP
rs764317616 1645 dbSNP
rs907169719 1646 dbSNP
rs891082317 1648 dbSNP
rs943857282 1654 dbSNP
rs573643456 1656 dbSNP
rs1257272521 1659 dbSNP
rs1310867519 1661 dbSNP
rs1347731452 1675 dbSNP
rs1219522139 1676 dbSNP
rs1317497972 1677 dbSNP
rs1276484461 1679 dbSNP
rs542361987 1689 dbSNP
rs780431096 1696 dbSNP
rs934662843 1699 dbSNP
rs559446810 1702 dbSNP
rs1053589485 1703 dbSNP
rs747515533 1704 dbSNP
rs995643366 1705 dbSNP
rs1422503979 1708 dbSNP
rs893203101 1711 dbSNP
rs1432854551 1712 dbSNP
rs1413866589 1714 dbSNP
rs1181854754 1718 dbSNP
rs1199612108 1719 dbSNP
rs1012106459 1726 dbSNP
rs1199686672 1727 dbSNP
rs1457565479 1729 dbSNP
rs768339753 1731 dbSNP
rs1256401716 1736 dbSNP
rs886764112 1737 dbSNP
rs1003920439 1738 dbSNP
rs1312089211 1739 dbSNP
rs1451499167 1748 dbSNP
rs1227712354 1750 dbSNP
rs528066706 1762 dbSNP
rs1333234348 1768 dbSNP
rs971667769 1782 dbSNP
rs1447290543 1784 dbSNP
rs981703326 1786 dbSNP
rs747621423 1788 dbSNP
rs1323646186 1790 dbSNP
rs958863633 1791 dbSNP
rs1349998927 1796 dbSNP
rs1163434047 1802 dbSNP
rs1442186314 1803 dbSNP
rs990605502 1810 dbSNP
rs1393223157 1813 dbSNP
rs1179736065 1820 dbSNP
rs1387012644 1822 dbSNP
rs1008396650 1827 dbSNP
rs1019835106 1832 dbSNP
rs545058088 1833 dbSNP
rs150894778 1834 dbSNP
rs993827952 1845 dbSNP
rs946037093 1847 dbSNP
rs977474352 1848 dbSNP
rs751710813 1854 dbSNP
rs886045724 1859 dbSNP
rs114073917 1861 dbSNP
rs991014556 1866 dbSNP
rs1288213600 1878 dbSNP
rs943930768 1881 dbSNP
rs1039617468 1899 dbSNP
rs1375958831 1901 dbSNP
rs769354344 1908 dbSNP
rs190426825 1909 dbSNP
rs970557742 1922 dbSNP
rs1367893733 1924 dbSNP
rs931194459 1930 dbSNP
rs139430054 1932 dbSNP
rs1271688720 1937 dbSNP
rs1048614318 1944 dbSNP
rs886884666 1954 dbSNP
rs886045725 1957 dbSNP
rs935259644 1964 dbSNP
rs1488265476 1970 dbSNP
rs1004272469 1975 dbSNP
rs1210701199 1976 dbSNP
rs1053115144 1983 dbSNP
rs886045726 1986 dbSNP
rs1197459151 1998 dbSNP
rs1489321592 2012 dbSNP
rs1417465088 2017 dbSNP
rs947493749 2020 dbSNP
rs1412529892 2039 dbSNP
rs886045727 2044 dbSNP
rs1003087058 2048 dbSNP
rs1034609373 2051 dbSNP
rs959120097 2061 dbSNP
rs1011788146 2066 dbSNP
rs1050276291 2067 dbSNP
rs1022110724 2074 dbSNP
rs889921738 2077 dbSNP
rs1008367163 2079 dbSNP
rs182563953 2081 dbSNP
rs967518741 2084 dbSNP
rs150030810 2086 dbSNP
rs1341907407 2092 dbSNP
rs897397501 2099 dbSNP
rs912541650 2104 dbSNP
rs1026648196 2105 dbSNP
rs965354967 2112 dbSNP
rs1377371400 2114 dbSNP
rs1466881920 2114 dbSNP
rs1046869 2115 dbSNP
rs566197187 2116 dbSNP
rs1174631822 2120 dbSNP
rs534677734 2121 dbSNP
rs952484065 2129 dbSNP
rs886045728 2132 dbSNP
rs1264052652 2135 dbSNP
rs1011964883 2141 dbSNP
rs1445313334 2146 dbSNP
rs975291512 2149 dbSNP
rs1259579200 2156 dbSNP
rs1202051610 2159 dbSNP
rs1345520673 2168 dbSNP
rs1262274604 2174 dbSNP
rs1023403315 2179 dbSNP
rs1351591415 2180 dbSNP
rs878949293 2193 dbSNP
rs1278381694 2194 dbSNP
rs1226103367 2197 dbSNP
rs921217659 2205 dbSNP
rs931119008 2206 dbSNP
rs1291785578 2209 dbSNP
rs981922949 2219 dbSNP
rs1048251918 2233 dbSNP
rs1401989227 2252 dbSNP
rs1335110018 2253 dbSNP
rs1467463334 2253 dbSNP
rs1424644960 2257 dbSNP
rs908383718 2259 dbSNP
rs939762446 2260 dbSNP
rs762659341 2263 dbSNP
rs989845183 2265 dbSNP
rs1245778309 2266 dbSNP
rs1189619873 2282 dbSNP
rs1442905011 2285 dbSNP
rs1267395423 2299 dbSNP
rs1201560635 2303 dbSNP
rs144363422 2305 dbSNP
rs1258314878 2306 dbSNP
rs12067264 2319 dbSNP
rs1285415317 2327 dbSNP
rs1204468637 2343 dbSNP
rs1382720978 2346 dbSNP
rs1049809792 2350 dbSNP
rs1449470259 2351 dbSNP
rs1483980935 2357 dbSNP
rs1185804528 2367 dbSNP
rs1401406578 2369 dbSNP
rs1255204586 2378 dbSNP
rs866427443 2379 dbSNP
rs1001903755 2384 dbSNP
rs1393021858 2386 dbSNP
rs1163889714 2397 dbSNP
rs879269443 2401 dbSNP
rs1041188381 2409 dbSNP
rs1181611046 2409 dbSNP
rs571175984 2410 dbSNP
rs1056056361 2420 dbSNP
rs536960020 2421 dbSNP
rs372585994 2428 dbSNP
rs1435690872 2431 dbSNP
rs1291518253 2444 dbSNP
rs572307472 2447 dbSNP
rs888091632 2448 dbSNP
rs1242933551 2454 dbSNP
rs886045729 2456 dbSNP
rs967970230 2460 dbSNP
rs1023331145 2461 dbSNP
rs906270357 2464 dbSNP
rs1424108034 2472 dbSNP
rs1363733740 2473 dbSNP
rs1161658821 2477 dbSNP
rs1421440694 2478 dbSNP
rs1209496382 2480 dbSNP
rs1380731450 2489 dbSNP
rs1379100256 2491 dbSNP
rs1468369011 2500 dbSNP
rs998859649 2501 dbSNP
rs1003330578 2511 dbSNP
rs1030837939 2515 dbSNP
rs1266143404 2520 dbSNP
rs573752666 2526 dbSNP
rs956751915 2538 dbSNP
rs76148009 2544 dbSNP
rs1284126813 2547 dbSNP
rs965344611 2553 dbSNP
rs140807921 2555 dbSNP
rs1022649815 2557 dbSNP
rs1340241223 2557 dbSNP
rs1347498546 2557 dbSNP
rs186656311 2558 dbSNP
rs1404558948 2563 dbSNP
rs1228003651 2564 dbSNP
rs1343794605 2566 dbSNP
rs1300084825 2572 dbSNP
rs975406287 2576 dbSNP
rs1345744563 2577 dbSNP
rs921164763 2578 dbSNP
rs1398752683 2580 dbSNP
rs1426992322 2583 dbSNP
rs953342411 2589 dbSNP
rs1266213109 2593 dbSNP
rs1195243212 2594 dbSNP
rs952629440 2597 dbSNP
rs984462173 2600 dbSNP
rs561336515 2604 dbSNP
rs531872328 2626 dbSNP
rs939856473 2627 dbSNP
rs1183331506 2629 dbSNP
rs544986367 2633 dbSNP
rs1046171773 2634 dbSNP
rs564883182 2639 dbSNP
rs1361287206 2640 dbSNP
rs1288273674 2641 dbSNP
rs578238143 2651 dbSNP
rs886045730 2652 dbSNP
rs1360723768 2658 dbSNP
rs927738419 2661 dbSNP
rs1337122393 2663 dbSNP
rs1469056960 2664 dbSNP
rs1426807966 2665 dbSNP
rs192018514 2678 dbSNP
rs1188879435 2679 dbSNP
rs1048617160 2687 dbSNP
rs888677465 2687 dbSNP
rs1474044012 2695 dbSNP
rs373238501 2698 dbSNP
rs948359159 2698 dbSNP
rs564048660 2701 dbSNP
rs1260249418 2703 dbSNP
rs1199490826 2704 dbSNP
rs1359048359 2705 dbSNP
rs750593209 2715 dbSNP
rs906239417 2722 dbSNP
rs1293482997 2725 dbSNP
rs1212784835 2743 dbSNP
rs756490684 2771 dbSNP
rs947642001 2776 dbSNP
rs1381280618 2777 dbSNP
rs1043707313 2780 dbSNP
rs1451656467 2784 dbSNP
rs529447734 2793 dbSNP
rs1403557989 2795 dbSNP
rs866965180 2799 dbSNP
rs999015399 2802 dbSNP
rs549580789 2805 dbSNP
rs1167682189 2814 dbSNP
rs1019636013 2820 dbSNP
rs1386411327 2825 dbSNP
rs1363512713 2832 dbSNP
rs1183453810 2839 dbSNP
rs1443228769 2840 dbSNP
rs1240408375 2864 dbSNP
rs1434633784 2873 dbSNP
rs1480417278 2878 dbSNP
rs1249785939 2879 dbSNP
rs1223908229 2880 dbSNP
rs1322334705 2887 dbSNP
rs901293519 2889 dbSNP
rs1380397108 2890 dbSNP
rs996898906 2891 dbSNP
rs1311144465 2899 dbSNP
rs1367631488 2906 dbSNP
rs1028300757 2930 dbSNP
rs1011136265 2935 dbSNP
rs1296019874 2940 dbSNP
rs1022155888 2943 dbSNP
rs952824530 2945 dbSNP
rs144681513 2951 dbSNP
rs1423254102 2952 dbSNP
rs147904515 2963 dbSNP
rs886045731 2964 dbSNP
rs1418823358 2965 dbSNP
rs981966719 2969 dbSNP
rs1248691872 2978 dbSNP
rs1018190453 2981 dbSNP
rs886045732 2983 dbSNP
rs1249431396 2995 dbSNP
rs780552985 3001 dbSNP
rs1357167270 3004 dbSNP
rs1190069611 3007 dbSNP
rs1239504957 3013 dbSNP
rs990996435 3020 dbSNP
rs914876058 3023 dbSNP
rs1304488372 3026 dbSNP
rs1425317421 3027 dbSNP
rs1434225360 3036 dbSNP
rs930100660 3040 dbSNP
rs946384834 3048 dbSNP
rs1301963365 3051 dbSNP
rs1043309182 3057 dbSNP
rs1363038052 3059 dbSNP
rs551321945 3063 dbSNP
rs182545034 3064 dbSNP
rs1041165659 3065 dbSNP
rs1178592184 3066 dbSNP
rs1390701258 3076 dbSNP
rs1391044929 3076 dbSNP
rs1428746528 3082 dbSNP
rs910086650 3086 dbSNP
rs886045733 3087 dbSNP
rs185781840 3091 dbSNP
rs1045344829 3105 dbSNP
rs996847112 3106 dbSNP
rs141516447 3107 dbSNP
rs1258703722 3110 dbSNP
rs567587199 3117 dbSNP
rs1323833596 3118 dbSNP
rs939014174 3122 dbSNP
rs1221160846 3138 dbSNP
rs1052121857 3151 dbSNP
rs1028833410 3154 dbSNP
rs1319625247 3156 dbSNP
rs1382154567 3168 dbSNP
rs536039740 3181 dbSNP
rs892194287 3193 dbSNP
rs1220858513 3197 dbSNP
rs888445576 3201 dbSNP
rs142813353 3202 dbSNP
rs1174468496 3204 dbSNP
rs1478875017 3219 dbSNP
rs1952018 3220 dbSNP
rs1043945643 3222 dbSNP
rs1015492419 3227 dbSNP
rs961313772 3229 dbSNP
rs1193858551 3230 dbSNP
rs888956601 3231 dbSNP
rs1328395218 3234 dbSNP
rs1007396445 3237 dbSNP
rs11551121 3239 dbSNP
rs1205364953 3249 dbSNP
rs1320675582 3251 dbSNP
rs982039077 3252 dbSNP
rs1209077484 3254 dbSNP
rs1018831136 3255 dbSNP
rs886045734 3258 dbSNP
rs1340947442 3264 dbSNP
rs532839308 3267 dbSNP
rs959198126 3275 dbSNP
rs990552351 3281 dbSNP
rs1227408377 3282 dbSNP
rs1325226880 3283 dbSNP
rs998124025 3294 dbSNP
rs1449489007 3297 dbSNP
rs1405787065 3298 dbSNP
rs1335045868 3303 dbSNP
rs1467346681 3303 dbSNP
rs547727220 3305 dbSNP
rs946382347 3315 dbSNP
rs1025673092 3318 dbSNP
rs1460493582 3320 dbSNP
rs1246775498 3324 dbSNP
rs1185285001 3325 dbSNP
rs1489143750 3331 dbSNP
rs1242297899 3335 dbSNP
rs1174982740 3343 dbSNP
rs1439174697 3354 dbSNP
rs978188470 3376 dbSNP
rs1410350206 3393 dbSNP
rs951539736 3394 dbSNP
rs115902405 3395 dbSNP
rs1160336625 3401 dbSNP
rs1294655062 3404 dbSNP
rs777243964 3404 dbSNP
rs1313340647 3406 dbSNP
rs1382549470 3406 dbSNP
rs886045735 3406 dbSNP
rs910003708 3406 dbSNP
rs1336610243 3414 dbSNP
rs1403810676 3414 dbSNP
rs1323207944 3419 dbSNP
rs566373225 3420 dbSNP
rs1367515250 3421 dbSNP
rs1165468665 3455 dbSNP
rs1425189028 3457 dbSNP
rs1384436577 3459 dbSNP
rs1161471118 3464 dbSNP
rs1041301268 3465 dbSNP
rs1296489406 3468 dbSNP
rs1233109076 3473 dbSNP
rs1471018502 3473 dbSNP
rs980994213 3474 dbSNP
rs1435635188 3481 dbSNP
rs928221648 3482 dbSNP
rs922745689 3484 dbSNP
rs939609834 3487 dbSNP
rs561074766 3490 dbSNP
rs1290167434 3493 dbSNP
rs913606075 3499 dbSNP
rs1351777454 3501 dbSNP
rs1349739877 3506 dbSNP
rs151216299 3508 dbSNP
rs1347512973 3510 dbSNP
rs1303816591 3517 dbSNP
rs1289946051 3520 dbSNP
rs1246772830 3522 dbSNP
rs1049818253 3523 dbSNP
rs548190260 3525 dbSNP
rs1007365395 3526 dbSNP
rs886045736 3543 dbSNP
rs1290068500 3549 dbSNP
rs1408432499 3561 dbSNP
rs1157672758 3562 dbSNP
rs1468260254 3575 dbSNP
rs1430908667 3577 dbSNP
rs1005542664 3578 dbSNP
rs1323181105 3579 dbSNP
rs1040208479 3592 dbSNP
rs1037405869 3596 dbSNP
rs1448005594 3596 dbSNP
rs897160432 3600 dbSNP
rs1222332525 3601 dbSNP
rs745622946 3605 dbSNP
rs1026063039 3608 dbSNP
rs1343659299 3616 dbSNP
rs951417244 3616 dbSNP
rs1273069965 3618 dbSNP
rs1003436762 3622 dbSNP
rs1345616538 3635 dbSNP
rs565579791 3642 dbSNP
rs1034946952 3643 dbSNP
rs574298616 3648 dbSNP
rs1176630749 3651 dbSNP
rs1479857080 3656 dbSNP
rs1234950189 3659 dbSNP
rs1422439457 3660 dbSNP
rs1188870702 3669 dbSNP
rs868032886 3679 dbSNP
rs1471980306 3684 dbSNP
rs1476019065 3687 dbSNP
rs1163046304 3692 dbSNP
rs959177185 3698 dbSNP
rs1407316840 3700 dbSNP
rs1012514861 3705 dbSNP
rs886045737 3715 dbSNP
rs968170204 3720 dbSNP
rs1203242605 3723 dbSNP
rs1321588422 3724 dbSNP
rs868845890 3727 dbSNP
rs1275193966 3735 dbSNP
rs977872570 3737 dbSNP
rs1410353800 3739 dbSNP
rs1309837563 3744 dbSNP
rs767823715 3749 dbSNP
rs923586284 3760 dbSNP
rs1446968173 3764 dbSNP
rs1432663390 3767 dbSNP
rs965697654 3770 dbSNP
rs748954781 3771 dbSNP
rs1337028451 3784 dbSNP
rs976959619 3785 dbSNP
rs886045738 3786 dbSNP
rs74130943 3787 dbSNP
rs528519878 3788 dbSNP
rs551461071 3791 dbSNP
rs886045739 3792 dbSNP
rs941401913 3793 dbSNP
rs1342332735 3797 dbSNP
rs1187170254 3804 dbSNP
rs746529105 3805 dbSNP
rs143131672 3808 dbSNP
rs886045740 3808 dbSNP
rs1275640086 3829 dbSNP
rs1037135520 3840 dbSNP
rs1183287478 3846 dbSNP
rs897128738 3850 dbSNP
rs1003571653 3859 dbSNP
rs1253226513 3865 dbSNP
rs1056375292 3870 dbSNP
rs943151694 3879 dbSNP
rs895099989 3880 dbSNP
rs1446637665 3893 dbSNP
rs1186981264 3905 dbSNP
rs901725473 3905 dbSNP
rs1389616443 3911 dbSNP
rs1430415470 3914 dbSNP
rs1012176044 3921 dbSNP
rs1442324083 3929 dbSNP
rs1353388079 3934 dbSNP
rs1399920138 3937 dbSNP
rs565081054 3939 dbSNP
rs1047650129 3942 dbSNP
rs1163348762 3946 dbSNP
rs1422395663 3947 dbSNP
rs1022511306 3953 dbSNP
rs1252958294 3963 dbSNP
rs1334533897 3972 dbSNP
rs189653401 3975 dbSNP
rs1177977050 3978 dbSNP
rs887080256 3982 dbSNP
rs1249709184 3983 dbSNP
rs182327121 3988 dbSNP
rs1490823814 3991 dbSNP
rs1292320969 3999 dbSNP
rs1245011504 4007 dbSNP
rs999654560 4010 dbSNP
rs1030738035 4018 dbSNP
rs1308755528 4018 dbSNP
rs1017375724 4026 dbSNP
rs965665104 4038 dbSNP
rs1305660093 4042 dbSNP
rs1406178689 4057 dbSNP
rs1366772442 4058 dbSNP
rs1303025767 4064 dbSNP
rs1456758830 4066 dbSNP
rs1365881249 4073 dbSNP
rs1160194380 4079 dbSNP
rs776324947 4080 dbSNP
rs188015996 4094 dbSNP
rs577414726 4099 dbSNP
rs1490522355 4104 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000367435.3 | 3UTR | AGAAGAAAUGGAUGGUGAAAAAGAAUUGCUGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.659 2.3e-4 -0.648 3.1e-4 24 Click to see details
GSE21687 Ependynoma primary tumors -0.238 2.9e-2 -0.046 3.6e-1 64 Click to see details
GSE32688 Pancreatic cancer -0.337 3.0e-2 -0.342 2.8e-2 32 Click to see details
GSE42095 Differentiated embryonic stem cells 0.385 3.5e-2 0.486 9.4e-3 23 Click to see details
GSE38226 Liver fibrosis 0.374 4.7e-2 0.435 2.4e-2 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.339 4.9e-2 0.396 2.5e-2 25 Click to see details
GSE28260 Renal cortex and medulla 0.435 6.9e-2 0.346 1.2e-1 13 Click to see details
GSE17498 Multiple myeloma 0.154 1.7e-1 0.121 2.3e-1 40 Click to see details
GSE19350 CNS germ cell tumors -0.191 2.8e-1 0.119 3.6e-1 12 Click to see details
GSE26953 Aortic valvular endothelial cells 0.08 3.6e-1 0.047 4.1e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.032 4.5e-1 -0.598 2.7e-3 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.032 4.5e-1 -0.598 2.7e-3 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
0.032 4.5e-1 -0.598 2.7e-3 20 Click to see details
0.032 4.5e-1 -0.598 2.7e-3 20 Click to see details
0.032 4.5e-1 -0.598 2.7e-3 20 Click to see details
65 hsa-miR-124-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064177 KIAA1804 mitogen-activated protein kinase kinase kinase 21 2 2
MIRT069736 FOXG1 forkhead box G1 2 4
MIRT086429 NABP1 nucleic acid binding protein 1 2 6
MIRT105334 SLC7A2 solute carrier family 7 member 2 2 4
MIRT110455 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT172998 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT196428 TAOK1 TAO kinase 1 2 14
MIRT325704 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT365670 TSC22D3 TSC22 domain family member 3 2 4
MIRT365873 XIAP X-linked inhibitor of apoptosis 2 2
MIRT404126 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT404626 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT405284 ARF1 ADP ribosylation factor 1 2 2
MIRT406099 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT446627 SDC3 syndecan 3 2 2
MIRT446906 RGS5 regulator of G protein signaling 5 2 2
MIRT461790 FXR2 FMR1 autosomal homolog 2 2 2
MIRT463982 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT464204 VGLL4 vestigial like family member 4 2 2
MIRT472790 MTMR4 myotubularin related protein 4 2 4
MIRT473485 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT481124 AZIN1 antizyme inhibitor 1 2 4
MIRT485060 SUCO SUN domain containing ossification factor 2 2
MIRT487343 HLA-DRA major histocompatibility complex, class II, DR alpha 2 2
MIRT491948 VPS52 VPS52, GARP complex subunit 2 2
MIRT497208 CDH7 cadherin 7 2 2
MIRT497476 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT528203 NELFE negative elongation factor complex member E 2 2
MIRT529255 TRIM4 tripartite motif containing 4 2 4
MIRT530096 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530597 C7orf33 chromosome 7 open reading frame 33 2 4
MIRT534980 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT538326 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2 2
MIRT561237 ZNF652 zinc finger protein 652 2 2
MIRT562035 KRAS KRAS proto-oncogene, GTPase 2 2
MIRT563120 THAP5 THAP domain containing 5 2 2
MIRT563538 RBM41 RNA binding motif protein 41 2 2
MIRT566037 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT566505 PAWR pro-apoptotic WT1 regulator 2 2
MIRT566745 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT566850 LRRC58 leucine rich repeat containing 58 2 2
MIRT568077 CELF2 CUGBP Elav-like family member 2 2 2
MIRT576826 Tgfbr3 transforming growth factor, beta receptor III 2 2
MIRT608870 NR2E1 nuclear receptor subfamily 2 group E member 1 2 4
MIRT611997 VAC14 Vac14, PIKFYVE complex component 2 2
MIRT614054 FAM89A family with sequence similarity 89 member A 2 2
MIRT618800 SPATA21 spermatogenesis associated 21 2 2
MIRT619389 RSPH3 radial spoke head 3 homolog 2 2
MIRT622282 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624026 EN2 engrailed homeobox 2 2 2
MIRT626000 MPEG1 macrophage expressed 1 2 2
MIRT641792 USP32 ubiquitin specific peptidase 32 2 2
MIRT651599 WDFY2 WD repeat and FYVE domain containing 2 2 2
MIRT659662 CDC73 cell division cycle 73 2 2
MIRT663010 KIAA1586 KIAA1586 2 2
MIRT663561 ASTN2 astrotactin 2 2 2
MIRT669312 C16orf72 chromosome 16 open reading frame 72 2 2
MIRT685216 POTED POTE ankyrin domain family member D 2 2
MIRT695757 ZNF117 zinc finger protein 117 2 2
MIRT697909 TXNRD1 thioredoxin reductase 1 2 2
MIRT707181 RPH3A rabphilin 3A 2 2
MIRT707214 TRIM13 tripartite motif containing 13 2 2
MIRT707478 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT719507 LMAN2L lectin, mannose binding 2 like 2 2
MIRT755814 PARP1 poly(ADP-ribose) polymerase 1 2 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-124 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) NULL 16078949 Microarray hepatocytes 23107762 2013 up-regulated
miR-124 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-124 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-124 Cocaine NULL 446220 Quantitative real-time PCR HEK293 cells or rat brain parts 19703567 2009 down-regulated
miR-124 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-124 Chaihu Shugan San NULL NULL Microarray hippocampus 23947143 2013 up-regualted
miR-124 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-124 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved resistant High Laryngeal Cancer cell line (Hep2)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (MGC803)
hsa-miR-124-5p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-124-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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