miRTarBase - #MIRT660041


—
pre-miRNA Information
pre-miRNA hsa-mir-3911   
Genomic Coordinates chr9: 127690687 - 127690795
Description Homo sapiens miR-3911 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3911
Sequence 12| UGUGUGGAUCCUGGAGGAGGCA |33
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
431152 7 ClinVar
COSM3847691 15 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs943029638 2 dbSNP
rs780635543 3 dbSNP
rs371437556 6 dbSNP
rs1135401819 7 dbSNP
rs748706130 14 dbSNP
rs1403241180 15 dbSNP
rs779344153 17 dbSNP
rs755366929 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol C15orf61   
Synonyms -
Description chromosome 15 open reading frame 61
Transcript NM_001143936   
Expression
Putative miRNA Targets on C15orf61
3'UTR of C15orf61
(miRNA target sites are highlighted)		 
>C15orf61|NM_001143936|3'UTR
   1 AAGTGTGCGTCAAAGAACATAAATATCAGTGGATTTTCTCTGTGTATATGTGCAGTATTTATTTTTGATCCTTTAAAATA
  81 AAACTTTTGCAAATACTTTTTTCTTTCTACAGTATCTGCTTCTTTAAGATGAATCATTGCCCTCAAGAGGTGAAGCTTTT
 161 TATACATCGTTATATATTACATACTCTGTTTAGCTGATGTGAACTACAAACACATGAAGCTTCACACCATTTTTTCCCTA
 241 GAACTAGGTTAACCTACAGATAAAAAATGATTACAATGTAATAGATTCTATAGTTAATTAACAATTTAAATCAACTCTGA
 321 AGAGAAAATATAGATGCCCACACAAAAGAGAAGGGGGGAAAATCTTTTATGTAACAATGGAAAAAGAAGTAGAAGACATT
 401 AGGATGTATGATGGAAATATTACATCATTGGCAAATCCAAAATTGATGAGAATCTAATTGTAATCTCAAGTCTAAACCAT
 481 TCAGCTGCCAGGATTGTAAATAGAAACGTTTTAAAGGCCTTGTGCCATTTACCTGGAGGAGGGGTTGGAGTGTAATGTTG
 561 AAACTTCTTGTTGCTTAAAGAGTCCAAAACCATATCGTTTGTAAAATGTAATAATAACTGGTTAATATAAGTGTAGCAAG
 641 GTGAATGAAACTCAGACTTATTAAAAGTTAAAACAGCTTTCCTATAAAGCTGTAAGAACAATTAAGATCTTCTAGAAAGA
 721 TGCAGAAAAATAAATTTGGTAACTGTTTATAAAAGCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acggaggagGUCCU---AGGUGUGu 5'
                   || ||   |:||||| 
Target 5' ctacaaacaCATGAAGCTTCACACc 3'
 204 - 228 129.00 -7.70
2 
miRNA  3' acggaggagguccuaGGUGUGu 5'
                         |||||| 
Target 5' agaaaatatagatgcCCACACa 3'
 323 - 344 120.00 -12.50
3 
miRNA  3' acGGAGGAGGUCCUAGGUGUgu 5'
            |:|::|:|    ||:|||  
Target 5' taCTTTTTTC--TTTCTACAgt 3'
 94 - 113 112.00 -11.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30733352 26 COSMIC
COSN16633296 182 COSMIC
COSN20208084 385 COSMIC
COSN25770068 490 COSMIC
COSN21629637 834 COSMIC
COSN8389907 888 COSMIC
COSN24483597 1131 COSMIC
COSN28313924 2115 COSMIC
COSN23455173 2158 COSMIC
COSN20911220 3350 COSMIC
COSN5400135 3594 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs755737894 3 dbSNP
rs1165695368 4 dbSNP
rs1389918323 7 dbSNP
rs777390551 9 dbSNP
rs574020770 10 dbSNP
rs542937252 14 dbSNP
rs1387732083 20 dbSNP
rs1187574821 25 dbSNP
rs951338389 28 dbSNP
rs1356827391 47 dbSNP
rs982762923 49 dbSNP
rs553052874 56 dbSNP
rs1224221788 59 dbSNP
rs144220753 70 dbSNP
rs970828724 73 dbSNP
rs1258290972 74 dbSNP
rs754157837 75 dbSNP
rs1196510975 81 dbSNP
rs1344439718 85 dbSNP
rs1272482195 87 dbSNP
rs1227956964 88 dbSNP
rs981052310 91 dbSNP
rs1276462496 93 dbSNP
rs1433988690 97 dbSNP
rs1330500404 98 dbSNP
rs557622287 108 dbSNP
rs921536598 112 dbSNP
rs1186078006 120 dbSNP
rs1050934883 123 dbSNP
rs926436684 126 dbSNP
rs957956469 137 dbSNP
rs569451928 140 dbSNP
rs936631531 142 dbSNP
rs1193329851 143 dbSNP
rs767896599 144 dbSNP
rs1167662062 155 dbSNP
rs537189814 157 dbSNP
rs1416632389 162 dbSNP
rs945065331 167 dbSNP
rs1484287611 169 dbSNP
rs564845902 170 dbSNP
rs1051423528 173 dbSNP
rs1313038949 174 dbSNP
rs911672369 184 dbSNP
rs775914132 185 dbSNP
rs1355538616 187 dbSNP
rs575272781 192 dbSNP
rs761198134 197 dbSNP
rs1411602229 201 dbSNP
rs1413560189 207 dbSNP
rs181454368 214 dbSNP
rs943096383 215 dbSNP
rs907028496 217 dbSNP
rs1327781515 227 dbSNP
rs1001409666 230 dbSNP
rs8027115 233 dbSNP
rs951831814 235 dbSNP
rs1424917571 236 dbSNP
rs1160347017 237 dbSNP
rs1005818357 245 dbSNP
rs753849929 250 dbSNP
rs899971750 253 dbSNP
rs1250204786 265 dbSNP
rs1014556320 277 dbSNP
rs961715361 296 dbSNP
rs530365527 298 dbSNP
rs1048701171 300 dbSNP
rs1442003258 303 dbSNP
rs1212921820 310 dbSNP
rs1229997986 313 dbSNP
rs546886221 324 dbSNP
rs765502058 328 dbSNP
rs185741438 332 dbSNP
rs1380753258 333 dbSNP
rs1300504300 336 dbSNP
rs560365854 340 dbSNP
rs986322291 344 dbSNP
rs1321688354 347 dbSNP
rs79582845 349 dbSNP
rs1459135370 353 dbSNP
rs1024971741 354 dbSNP
rs971222802 357 dbSNP
rs76681955 359 dbSNP
rs1002258850 360 dbSNP
rs151132895 361 dbSNP
rs866291822 365 dbSNP
rs988254875 369 dbSNP
rs1472630797 385 dbSNP
rs1478094735 388 dbSNP
rs1248848442 390 dbSNP
rs1210414318 409 dbSNP
rs913886487 410 dbSNP
rs949405346 413 dbSNP
rs957842043 419 dbSNP
rs1371686042 427 dbSNP
rs1323414969 431 dbSNP
rs1310036158 462 dbSNP
rs1045669813 476 dbSNP
rs907126710 493 dbSNP
rs989253467 503 dbSNP
rs190209246 508 dbSNP
rs552507969 509 dbSNP
rs966598684 512 dbSNP
rs1055649962 524 dbSNP
rs1433585466 525 dbSNP
rs987548147 527 dbSNP
rs1458918605 528 dbSNP
rs1352117984 534 dbSNP
rs911528984 566 dbSNP
rs1310504292 570 dbSNP
rs943127817 573 dbSNP
rs78661816 576 dbSNP
rs920324668 578 dbSNP
rs1190791101 594 dbSNP
rs1005913272 595 dbSNP
rs1382418487 597 dbSNP
rs745916012 598 dbSNP
rs1489445394 609 dbSNP
rs1263583307 610 dbSNP
rs897492377 614 dbSNP
rs112387515 628 dbSNP
rs558675439 629 dbSNP
rs887396490 633 dbSNP
rs187532708 638 dbSNP
rs192436784 640 dbSNP
rs1232234071 654 dbSNP
rs1262545935 660 dbSNP
rs1292317307 660 dbSNP
rs551444462 662 dbSNP
rs553314551 678 dbSNP
rs958217616 685 dbSNP
rs1428131555 695 dbSNP
rs1389744617 696 dbSNP
rs1176582480 708 dbSNP
rs1002716205 715 dbSNP
rs1434706289 716 dbSNP
rs1264950356 722 dbSNP
rs1190552443 738 dbSNP
rs1483308822 740 dbSNP
rs796355394 744 dbSNP
rs1202402742 752 dbSNP
rs1033791714 756 dbSNP
rs10518729 767 dbSNP
rs914023850 772 dbSNP
rs140201352 776 dbSNP
rs982137587 778 dbSNP
rs534400147 791 dbSNP
rs1404899846 796 dbSNP
rs1351634837 799 dbSNP
rs1309975504 805 dbSNP
rs756035919 814 dbSNP
rs1453089848 822 dbSNP
rs987378151 824 dbSNP
rs1019046201 838 dbSNP
rs774166907 852 dbSNP
rs1175074322 877 dbSNP
rs1472915973 877 dbSNP
rs941906562 888 dbSNP
rs964433117 897 dbSNP
rs1482456114 898 dbSNP
rs1036061198 904 dbSNP
rs974802711 905 dbSNP
rs1287934434 914 dbSNP
rs1382257905 916 dbSNP
rs1442866983 924 dbSNP
rs1326294448 930 dbSNP
rs747957016 932 dbSNP
rs897585408 946 dbSNP
rs370555434 949 dbSNP
rs1317600307 956 dbSNP
rs1290774595 959 dbSNP
rs1227050299 962 dbSNP
rs558503266 963 dbSNP
rs1259209656 970 dbSNP
rs183940208 975 dbSNP
rs1337174202 977 dbSNP
rs748745904 978 dbSNP
rs888809818 979 dbSNP
rs770547313 990 dbSNP
rs1390505064 993 dbSNP
rs1156897444 995 dbSNP
rs1046619814 999 dbSNP
rs906758366 1001 dbSNP
rs1179461750 1004 dbSNP
rs938052766 1006 dbSNP
rs1419171172 1007 dbSNP
rs1255014915 1016 dbSNP
rs958185251 1025 dbSNP
rs769695247 1026 dbSNP
rs1270333992 1031 dbSNP
rs1207402176 1036 dbSNP
rs1021011857 1039 dbSNP
rs1462672359 1042 dbSNP
rs543893921 1043 dbSNP
rs1393451231 1045 dbSNP
rs1433946665 1047 dbSNP
rs1314662431 1051 dbSNP
rs187638145 1051 dbSNP
rs970819668 1052 dbSNP
rs893897304 1058 dbSNP
rs959660165 1061 dbSNP
rs1010914521 1064 dbSNP
rs1164540349 1065 dbSNP
rs1020759182 1084 dbSNP
rs991417624 1085 dbSNP
rs909164972 1087 dbSNP
rs1450881089 1089 dbSNP
rs772867016 1089 dbSNP
rs902333124 1091 dbSNP
rs1009129371 1094 dbSNP
rs1036154235 1114 dbSNP
rs1304924032 1115 dbSNP
rs1357659331 1125 dbSNP
rs774190834 1131 dbSNP
rs918980413 1138 dbSNP
rs574693278 1140 dbSNP
rs1212102970 1143 dbSNP
rs1273026177 1146 dbSNP
rs1291047427 1149 dbSNP
rs1018894109 1150 dbSNP
rs1333158503 1165 dbSNP
rs964978378 1173 dbSNP
rs866179389 1182 dbSNP
rs933073362 1189 dbSNP
rs1207002569 1192 dbSNP
rs974474240 1195 dbSNP
rs1051975988 1196 dbSNP
rs888786690 1206 dbSNP
rs1027284433 1208 dbSNP
rs1331418552 1210 dbSNP
rs540384694 1213 dbSNP
rs1176169883 1217 dbSNP
rs1325478145 1218 dbSNP
rs1248970157 1229 dbSNP
rs951783777 1230 dbSNP
rs1384937575 1231 dbSNP
rs983168723 1233 dbSNP
rs1476021681 1243 dbSNP
rs554075189 1261 dbSNP
rs1007671948 1265 dbSNP
rs574234942 1268 dbSNP
rs772348878 1272 dbSNP
rs1403418798 1286 dbSNP
rs1172216726 1296 dbSNP
rs894066335 1305 dbSNP
rs1355082491 1306 dbSNP
rs1461404800 1308 dbSNP
rs776833708 1311 dbSNP
rs1489987136 1315 dbSNP
rs1021145938 1316 dbSNP
rs1357446317 1316 dbSNP
rs532809404 1327 dbSNP
rs1292928694 1330 dbSNP
rs192105982 1338 dbSNP
rs928269536 1351 dbSNP
rs938258549 1352 dbSNP
rs1296706393 1366 dbSNP
rs749018067 1366 dbSNP
rs1003612664 1368 dbSNP
rs1034218927 1393 dbSNP
rs1434287899 1397 dbSNP
rs1344796921 1417 dbSNP
rs1308153253 1427 dbSNP
rs775886998 1428 dbSNP
rs984534201 1432 dbSNP
rs562895358 1442 dbSNP
rs1414618008 1443 dbSNP
rs1203029259 1457 dbSNP
rs1174667365 1460 dbSNP
rs1479782626 1462 dbSNP
rs946822366 1465 dbSNP
rs1183054286 1473 dbSNP
rs1231177628 1475 dbSNP
rs1204105310 1482 dbSNP
rs1443199867 1486 dbSNP
rs879863824 1487 dbSNP
rs1486373899 1489 dbSNP
rs1280550217 1490 dbSNP
rs1221430655 1491 dbSNP
rs1322797678 1494 dbSNP
rs1288934098 1500 dbSNP
rs1042475384 1503 dbSNP
rs531761810 1505 dbSNP
rs1278387686 1506 dbSNP
rs1008766996 1507 dbSNP
rs919075328 1508 dbSNP
rs1188101421 1515 dbSNP
rs761092328 1533 dbSNP
rs1019192017 1541 dbSNP
rs900419722 1543 dbSNP
rs1166650519 1546 dbSNP
rs1051515927 1559 dbSNP
rs1473823316 1562 dbSNP
rs142484305 1563 dbSNP
rs1412124135 1565 dbSNP
rs996461512 1568 dbSNP
rs1027336830 1570 dbSNP
rs1435447117 1579 dbSNP
rs943011465 1582 dbSNP
rs1280181019 1584 dbSNP
rs1053467928 1586 dbSNP
rs951668492 1602 dbSNP
rs1433134132 1603 dbSNP
rs1315045672 1607 dbSNP
rs1283028904 1610 dbSNP
rs1004532908 1613 dbSNP
rs1009808024 1614 dbSNP
rs1380957825 1619 dbSNP
rs1014708770 1625 dbSNP
rs971544936 1634 dbSNP
rs982338871 1635 dbSNP
rs1306295725 1638 dbSNP
rs548707432 1639 dbSNP
rs568527358 1641 dbSNP
rs1004151890 1657 dbSNP
rs1459344357 1658 dbSNP
rs959663927 1666 dbSNP
rs1234436643 1677 dbSNP
rs1278966968 1679 dbSNP
rs1406049121 1686 dbSNP
rs1416003071 1687 dbSNP
rs1033732883 1689 dbSNP
rs1444183095 1692 dbSNP
rs991009878 1694 dbSNP
rs12437625 1699 dbSNP
rs761947636 1701 dbSNP
rs765268770 1703 dbSNP
rs1222136281 1707 dbSNP
rs1485431474 1714 dbSNP
rs1244858350 1715 dbSNP
rs868773006 1715 dbSNP
rs1186392900 1720 dbSNP
rs546790678 1725 dbSNP
rs924088631 1743 dbSNP
rs1173153364 1752 dbSNP
rs1360242115 1754 dbSNP
rs954535047 1764 dbSNP
rs944748888 1779 dbSNP
rs1423147048 1784 dbSNP
rs1437758427 1789 dbSNP
rs987712998 1790 dbSNP
rs750692255 1792 dbSNP
rs1161722622 1799 dbSNP
rs1424305870 1800 dbSNP
rs1391010456 1801 dbSNP
rs1170316019 1802 dbSNP
rs1402453531 1812 dbSNP
rs1319241565 1813 dbSNP
rs1426529105 1815 dbSNP
rs184190909 1823 dbSNP
rs910280098 1824 dbSNP
rs943126370 1830 dbSNP
rs989257635 1842 dbSNP
rs1266204389 1847 dbSNP
rs1221089532 1852 dbSNP
rs914891333 1870 dbSNP
rs1344779312 1875 dbSNP
rs1433392188 1876 dbSNP
rs576781107 1878 dbSNP
rs945063958 1888 dbSNP
rs1328308677 1891 dbSNP
rs1425737117 1898 dbSNP
rs996113358 1899 dbSNP
rs1295242272 1906 dbSNP
rs1302328268 1908 dbSNP
rs187157986 1921 dbSNP
rs150323103 1926 dbSNP
rs1347904110 1927 dbSNP
rs1301444477 1931 dbSNP
rs1404395566 1934 dbSNP
rs887679208 1940 dbSNP
rs1440803431 1947 dbSNP
rs1042654695 1963 dbSNP
rs906784536 1972 dbSNP
rs192691795 1975 dbSNP
rs1055719247 1976 dbSNP
rs1176485991 1979 dbSNP
rs1015000118 1986 dbSNP
rs895200902 1988 dbSNP
rs138295090 1996 dbSNP
rs1483100305 2002 dbSNP
rs1284553088 2014 dbSNP
rs540622490 2017 dbSNP
rs1480094011 2022 dbSNP
rs752467537 2031 dbSNP
rs1211256517 2034 dbSNP
rs1314133698 2040 dbSNP
rs184582496 2042 dbSNP
rs574159816 2045 dbSNP
rs990937726 2048 dbSNP
rs1254629976 2065 dbSNP
rs1026150252 2086 dbSNP
rs60789873 2089 dbSNP
rs1192937177 2092 dbSNP
rs1303274113 2096 dbSNP
rs987294358 2106 dbSNP
rs1403546720 2109 dbSNP
rs1017842218 2113 dbSNP
rs1472849502 2119 dbSNP
rs968268436 2125 dbSNP
rs1179007032 2126 dbSNP
rs1418213159 2127 dbSNP
rs775909219 2135 dbSNP
rs978067132 2141 dbSNP
rs1183178596 2150 dbSNP
rs1471211275 2150 dbSNP
rs570938259 2152 dbSNP
rs1203644705 2158 dbSNP
rs189241854 2173 dbSNP
rs12904015 2174 dbSNP
rs1167625011 2177 dbSNP
rs180778631 2181 dbSNP
rs564883313 2187 dbSNP
rs1313711429 2198 dbSNP
rs564991591 2211 dbSNP
rs1380336598 2213 dbSNP
rs76931266 2214 dbSNP
rs77469155 2219 dbSNP
rs1457741295 2220 dbSNP
rs1461194959 2224 dbSNP
rs756880165 2233 dbSNP
rs922021345 2240 dbSNP
rs1156360055 2241 dbSNP
rs1452443297 2243 dbSNP
rs531748262 2245 dbSNP
rs778521289 2251 dbSNP
rs367666635 2256 dbSNP
rs1442337576 2257 dbSNP
rs1241732149 2262 dbSNP
rs939610071 2266 dbSNP
rs1048915675 2267 dbSNP
rs1264499927 2271 dbSNP
rs887730228 2273 dbSNP
rs1266058694 2274 dbSNP
rs572052503 2274 dbSNP
rs1248505348 2278 dbSNP
rs1004762137 2279 dbSNP
rs745540934 2280 dbSNP
rs12904044 2282 dbSNP
rs994105311 2284 dbSNP
rs184937626 2288 dbSNP
rs891157753 2291 dbSNP
rs1009211140 2299 dbSNP
rs1017559085 2306 dbSNP
rs1208966498 2307 dbSNP
rs1475949435 2310 dbSNP
rs138150940 2311 dbSNP
rs1010752294 2312 dbSNP
rs1439460750 2331 dbSNP
rs1446907899 2331 dbSNP
rs1224808895 2333 dbSNP
rs1489937061 2334 dbSNP
rs1291333685 2337 dbSNP
rs34444796 2346 dbSNP
rs1182686617 2349 dbSNP
rs1034544801 2353 dbSNP
rs966466518 2354 dbSNP
rs1190341705 2359 dbSNP
rs1418779664 2370 dbSNP
rs894221981 2374 dbSNP
rs1304494526 2395 dbSNP
rs977722986 2398 dbSNP
rs927605484 2402 dbSNP
rs527765830 2410 dbSNP
rs1161789227 2411 dbSNP
rs1411249552 2421 dbSNP
rs1422157051 2427 dbSNP
rs1166485137 2431 dbSNP
rs757542549 2436 dbSNP
rs1430589142 2437 dbSNP
rs747466678 2438 dbSNP
rs529970289 2442 dbSNP
rs968279807 2443 dbSNP
rs978719923 2445 dbSNP
rs1329018586 2447 dbSNP
rs1031018396 2452 dbSNP
rs1407389421 2455 dbSNP
rs966464282 2462 dbSNP
rs1294771118 2467 dbSNP
rs916848429 2468 dbSNP
rs941495591 2474 dbSNP
rs546511955 2478 dbSNP
rs976096411 2479 dbSNP
rs12904412 2483 dbSNP
rs532350003 2487 dbSNP
rs758482311 2490 dbSNP
rs891117759 2500 dbSNP
rs1443977283 2520 dbSNP
rs984624182 2530 dbSNP
rs1327337528 2532 dbSNP
rs1409762809 2540 dbSNP
rs552446886 2541 dbSNP
rs1179244502 2543 dbSNP
rs1468652131 2546 dbSNP
rs1428738053 2551 dbSNP
rs1177817229 2556 dbSNP
rs1471316037 2556 dbSNP
rs1196302666 2564 dbSNP
rs1231413460 2565 dbSNP
rs1181280095 2566 dbSNP
rs1273746067 2567 dbSNP
rs1461631798 2571 dbSNP
rs1482124892 2573 dbSNP
rs1201748006 2576 dbSNP
rs1039329213 2585 dbSNP
rs1322692367 2596 dbSNP
rs1284425776 2608 dbSNP
rs1224953329 2609 dbSNP
rs1370464724 2617 dbSNP
rs940608893 2619 dbSNP
rs1258530566 2620 dbSNP
rs12906075 2623 dbSNP
rs1448245612 2632 dbSNP
rs1384015212 2633 dbSNP
rs1339075983 2634 dbSNP
rs569015814 2639 dbSNP
rs1405982580 2646 dbSNP
rs907107340 2648 dbSNP
rs1010719475 2649 dbSNP
rs1375133952 2664 dbSNP
rs1022148756 2689 dbSNP
rs966561913 2700 dbSNP
rs1244788342 2701 dbSNP
rs999680845 2702 dbSNP
rs938383082 2714 dbSNP
rs537460813 2723 dbSNP
rs1242646492 2728 dbSNP
rs1055463211 2739 dbSNP
rs553253285 2742 dbSNP
rs894231866 2745 dbSNP
rs1282877632 2746 dbSNP
rs769883573 2748 dbSNP
rs1246317137 2759 dbSNP
rs1380006810 2776 dbSNP
rs916795125 2777 dbSNP
rs1011248357 2778 dbSNP
rs1022433362 2780 dbSNP
rs904006833 2782 dbSNP
rs1450935528 2807 dbSNP
rs563275740 2809 dbSNP
rs1314146623 2814 dbSNP
rs1290003572 2818 dbSNP
rs999679635 2824 dbSNP
rs1420855696 2825 dbSNP
rs1317689519 2827 dbSNP
rs930183268 2835 dbSNP
rs531586192 2836 dbSNP
rs1051606686 2844 dbSNP
rs912655554 2861 dbSNP
rs1031698627 2863 dbSNP
rs554114493 2864 dbSNP
rs1188225971 2866 dbSNP
rs567840142 2870 dbSNP
rs533624890 2873 dbSNP
rs554120181 2874 dbSNP
rs946601733 2879 dbSNP
rs1028957207 2885 dbSNP
rs1321524310 2890 dbSNP
rs1296713038 2898 dbSNP
rs953449288 2900 dbSNP
rs1360487922 2909 dbSNP
rs984842933 2916 dbSNP
rs189316908 2917 dbSNP
rs1405642804 2922 dbSNP
rs11632473 2925 dbSNP
rs909279743 2932 dbSNP
rs1339932280 2937 dbSNP
rs1043686865 2939 dbSNP
rs1424200769 2942 dbSNP
rs141341699 2943 dbSNP
rs1172223182 2944 dbSNP
rs971917308 2946 dbSNP
rs999376682 2947 dbSNP
rs1198949082 2952 dbSNP
rs1481151180 2954 dbSNP
rs1264047264 2961 dbSNP
rs1266094569 2964 dbSNP
rs1221348307 2965 dbSNP
rs1480737514 2969 dbSNP
rs1252325413 2971 dbSNP
rs1207051184 2972 dbSNP
rs1306070578 2981 dbSNP
rs780272925 2983 dbSNP
rs1278124548 2984 dbSNP
rs766561504 2989 dbSNP
rs181731561 2997 dbSNP
rs1347491728 2998 dbSNP
rs894117420 3006 dbSNP
rs947156038 3028 dbSNP
rs1042809495 3034 dbSNP
rs571666921 3035 dbSNP
rs902927676 3037 dbSNP
rs748151312 3038 dbSNP
rs112390795 3040 dbSNP
rs902093187 3041 dbSNP
rs1395156876 3043 dbSNP
rs962377844 3060 dbSNP
rs139024026 3067 dbSNP
rs562048757 3068 dbSNP
rs1170464315 3076 dbSNP
rs1252249709 3077 dbSNP
rs1386622604 3094 dbSNP
rs1175048956 3096 dbSNP
rs751714196 3110 dbSNP
rs7173821 3119 dbSNP
rs1326232771 3120 dbSNP
rs576070475 3120 dbSNP
rs1443001281 3122 dbSNP
rs1232602323 3123 dbSNP
rs1317530758 3125 dbSNP
rs564377096 3128 dbSNP
rs1311691514 3129 dbSNP
rs7172423 3134 dbSNP
rs1262745716 3135 dbSNP
rs1454578598 3137 dbSNP
rs1403799398 3138 dbSNP
rs1016393805 3144 dbSNP
rs1171874733 3149 dbSNP
rs975930406 3150 dbSNP
rs552050719 3152 dbSNP
rs1351634464 3155 dbSNP
rs1208548964 3161 dbSNP
rs972310995 3169 dbSNP
rs928454234 3175 dbSNP
rs960243695 3184 dbSNP
rs1241844875 3185 dbSNP
rs1470272354 3190 dbSNP
rs374489560 3192 dbSNP
rs796767146 3192 dbSNP
rs1267206683 3200 dbSNP
rs991343587 3201 dbSNP
rs1237212325 3205 dbSNP
rs902435711 3217 dbSNP
rs1196083524 3219 dbSNP
rs1247919334 3223 dbSNP
rs2583572 3243 dbSNP
rs1333462842 3252 dbSNP
rs947082424 3260 dbSNP
rs547935719 3265 dbSNP
rs1158230496 3268 dbSNP
rs896338439 3269 dbSNP
rs1042696456 3271 dbSNP
rs1462764485 3273 dbSNP
rs1165021369 3275 dbSNP
rs796866716 3277 dbSNP
rs1326520224 3284 dbSNP
rs924402967 3288 dbSNP
rs12439210 3290 dbSNP
rs547812629 3302 dbSNP
rs901980003 3320 dbSNP
rs1448054713 3321 dbSNP
rs1264035229 3329 dbSNP
rs1203453677 3332 dbSNP
rs998193521 3336 dbSNP
rs1050696212 3340 dbSNP
rs1224960041 3342 dbSNP
rs1357035136 3352 dbSNP
rs1283357222 3357 dbSNP
rs867952806 3358 dbSNP
rs1309209950 3360 dbSNP
rs995140861 3369 dbSNP
rs889364871 3371 dbSNP
rs567706918 3372 dbSNP
rs1398860117 3380 dbSNP
rs1228012939 3381 dbSNP
rs72747472 3383 dbSNP
rs1304608580 3386 dbSNP
rs750626551 3387 dbSNP
rs559885665 3392 dbSNP
rs757836320 3394 dbSNP
rs1422339875 3398 dbSNP
rs1389079647 3406 dbSNP
rs553843816 3409 dbSNP
rs1476060719 3412 dbSNP
rs1375299362 3418 dbSNP
rs570419112 3423 dbSNP
rs1477555673 3429 dbSNP
rs987342855 3432 dbSNP
rs1265404516 3438 dbSNP
rs1019765815 3444 dbSNP
rs779823399 3454 dbSNP
rs964581699 3456 dbSNP
rs1288963440 3457 dbSNP
rs962446860 3469 dbSNP
rs1341136874 3483 dbSNP
rs1487776331 3493 dbSNP
rs1207606891 3495 dbSNP
rs1217891886 3496 dbSNP
rs914668979 3503 dbSNP
rs1242043869 3509 dbSNP
rs1252040443 3510 dbSNP
rs1345651573 3523 dbSNP
rs1287688307 3528 dbSNP
rs947332526 3532 dbSNP
rs1472592252 3540 dbSNP
rs993569310 3549 dbSNP
rs540047869 3560 dbSNP
rs1181021405 3567 dbSNP
rs1035951687 3569 dbSNP
rs1410885445 3570 dbSNP
rs556459555 3571 dbSNP
rs75707312 3573 dbSNP
rs1169193837 3578 dbSNP
rs935250398 3595 dbSNP
rs1476082403 3596 dbSNP
rs1430119334 3602 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000342683.4 | 3UTR | AAAAGAGAAGGGGGGAAAAUCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC 0.831 0.08 1.000 0.5 4 Click to see details
HNSC 0.394 0.19 0.143 0.38 7 Click to see details
THCA -0.575 0.21 -0.400 0.3 4 Click to see details
BRCA 0.286 0.32 0.200 0.37 5 Click to see details
BRCA 0.286 0.32 0.200 0.37 5 Click to see details
BRCA 0.286 0.32 0.200 0.37 5 Click to see details
BRCA 0.286 0.32 0.200 0.37 5 Click to see details
BRCA 0.286 0.32 0.200 0.37 5 Click to see details
BRCA 0.286 0.32 0.200 0.37 5 Click to see details
BRCA 0.286 0.32 0.200 0.37 5 Click to see details
70 hsa-miR-3911 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT207399 MAT2A methionine adenosyltransferase 2A 2 6
MIRT284537 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT291946 TPM4 tropomyosin 4 2 2
MIRT293609 PVR poliovirus receptor 2 2
MIRT357688 PAIP2 poly(A) binding protein interacting protein 2 2 2
MIRT451607 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452110 IFITM1 interferon induced transmembrane protein 1 2 2
MIRT457804 KLHL25 kelch like family member 25 2 2
MIRT462730 EFNB1 ephrin B1 2 2
MIRT463219 ZNF131 zinc finger protein 131 2 2
MIRT464141 VPS28 VPS28, ESCRT-I subunit 2 2
MIRT467582 SLC7A5 solute carrier family 7 member 5 2 6
MIRT470824 PLXND1 plexin D1 2 2
MIRT474230 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT478989 COLGALT1 collagen beta(1-O)galactosyltransferase 1 2 2
MIRT479462 CDK6 cyclin dependent kinase 6 2 2
MIRT483558 SYT2 synaptotagmin 2 2 2
MIRT484483 SLC9A1 solute carrier family 9 member A1 2 2
MIRT485224 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT490356 DPYSL5 dihydropyrimidinase like 5 2 4
MIRT493177 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT509802 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT511815 HDGF heparin binding growth factor 2 2
MIRT512254 ARPP19 cAMP regulated phosphoprotein 19 2 6
MIRT513025 GPT2 glutamic--pyruvic transaminase 2 2 2
MIRT519640 ZNF772 zinc finger protein 772 2 4
MIRT531178 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT537870 EDA2R ectodysplasin A2 receptor 2 2
MIRT551914 IGLON5 IgLON family member 5 2 2
MIRT558359 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT559771 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 4
MIRT559813 ZNF83 zinc finger protein 83 2 2
MIRT561999 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT565754 SERTAD2 SERTA domain containing 2 2 2
MIRT569423 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT569845 RGS5 regulator of G protein signaling 5 2 2
MIRT606928 CDK15 cyclin dependent kinase 15 2 2
MIRT607616 TMEM130 transmembrane protein 130 2 4
MIRT607629 TRIOBP TRIO and F-actin binding protein 2 2
MIRT607885 SATB1 SATB homeobox 1 2 2
MIRT607942 SSX2 SSX family member 2 2 4
MIRT608017 CARNS1 carnosine synthase 1 2 4
MIRT608036 UBLCP1 ubiquitin like domain containing CTD phosphatase 1 2 2
MIRT608063 SSX2B SSX family member 2B 2 4
MIRT608558 SBK1 SH3 domain binding kinase 1 2 6
MIRT608915 NCDN neurochondrin 2 6
MIRT615876 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT618023 ELFN1 extracellular leucine rich repeat and fibronectin type III domain containing 1 2 2
MIRT620505 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT628101 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 2
MIRT628700 ZNF548 zinc finger protein 548 2 2
MIRT630658 POU2F1 POU class 2 homeobox 1 2 2
MIRT643508 ZNF28 zinc finger protein 28 2 2
MIRT646379 SLC22A6 solute carrier family 22 member 6 2 2
MIRT660041 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT687700 KRR1 KRR1, small subunit processome component homolog 2 2
MIRT688858 CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 2 2
MIRT690443 REPIN1 replication initiator 1 2 2
MIRT690456 ZNF33A zinc finger protein 33A 2 2
MIRT693796 RHOG ras homolog family member G 2 2
MIRT694274 ZNF529 zinc finger protein 529 2 4
MIRT697697 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT700242 RCC2 regulator of chromosome condensation 2 2 2
MIRT701836 MRPL37 mitochondrial ribosomal protein L37 2 2
MIRT704255 DHCR24 24-dehydrocholesterol reductase 2 2
MIRT707203 SDK2 sidekick cell adhesion molecule 2 2 2
MIRT710365 CREB5 cAMP responsive element binding protein 5 2 2
MIRT711943 WDFY1 WD repeat and FYVE domain containing 1 2 2
MIRT715496 MAZ MYC associated zinc finger protein 2 2
MIRT719250 MS4A1 membrane spanning 4-domains A1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-3911 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3911 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-3911 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3911 Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-mir-3911 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-3911 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-miR-3911 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-3911 Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-3911 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3911 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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