miRTarBase - #MIRT660900


—
pre-miRNA Information
pre-miRNA hsa-mir-6769b   
Genomic Coordinates chr1: 206474803 - 206474864
Description Homo sapiens miR-6769b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6769b-3p
Sequence 42| CCCUCUCUGUCCCACCCAUAG |62
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN26671848 9 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs555627187 3 dbSNP
rs782102173 4 dbSNP
rs201952639 7 dbSNP
rs782001154 9 dbSNP
rs1488064450 15 dbSNP
rs782111367 16 dbSNP
rs370859899 18 dbSNP
rs1305197911 19 dbSNP
Putative Targets

Gene Information
Gene Symbol ADCY6   
Synonyms AC6, LCCS8
Description adenylate cyclase 6
Transcript NM_015270   
Expression
Putative miRNA Targets on ADCY6
3'UTR of ADCY6
(miRNA target sites are highlighted)		 
>ADCY6|NM_015270|3'UTR
   1 CAGGGCCCAGCCACAAATTCAGCTGAAGGGACCAAGGTGGGCATTGAGTGGACTCTGTGCTCACTGGGTGGAGCTGTGGC
  81 AGGGGGCACTGAGCCTCCAGACCCTGCTAACCACAAAAGGGAACATCCCAGCAGGCTGTGCTTGGATCATGCTCGTCTGC
 161 CCTCAAGCTGGAAAACAAGGGGCTACCTACCGAGAGGATTATGCAAGTGACTTTCTTTCTTACTTGGGGTAGGGCTGTTC
 241 CCTCTCCAATCTTCCAGCCTTTGGGAGCAGGGGAGGGGTCAGTAGCAGAAGCAGAGGGAGGCCTCTTGCCTGAGGGATTA
 321 AAATGGCAGCTTGCCATGCCTACCCTTCCCTGTCTGTCTGGGCAGCAGGTTCAGGGCTGAGCCCTTCTTTTCCCTCTTTT
 401 TTCCTGGGAATATTTTGTACAATATTTTGTACAAAGACAGGCATGAGGAGTGCCTATTCCATGCTTGCCTTTGCAATACC
 481 TGCATCCCCAGCACTGGTCCTGGGCACTTCCCCACCCCAGCCAGGTGTCCCTCCTATGCACAGAGCAGAGGAGGGAGAAG
 561 CTCTGGGGAGCCAGCTTTGGCCATATTTCAGGAGAATGTTTCCATGTGCCAAATCTTAGTCCCATGATCTGTCCCCAAAG
 641 GGGAACAAAGGGACCTCTGACAGCTTAGATTTAGCCCCAGTTCCTGCACGCTCCAGGGAACGGGGTGTCTGGCCTCACTG
 721 GTACTGTGAAAAATGCTCAGAGAGCAAGCCTGTGTGTGGGGATGTCAGGTCAGGAGCTGGAAGTTCACCTGCAGGTGCCA
 801 AAGAGCAGGCCGGCCAGGGCTGGGGCAGTGCCAGACTCTGATCTGAGGACCCCGTCGGGGTCCAGATCAGGTCACTCTGC
 881 CCCAGTGCTCTCTTGCTGTCTGCTGACAAGGGGGCATGGAGCATCTCTTCCTCTTCTGTTGCCAAATAGAAAAGGGTCAG
 961 GGCATGGAGAAAGGTGACCCTGATCCCAAACCTGCCCTCCCAAGTCTCTGGTGTTGGGGAGGGCCCGTGTGTTTGTGTAA
1041 CTGTGTGTGCATGTTGGTCTTTGTGTGCATATCTGTTTTCCAGGTCTATGTGAGTCCTTGTGCTCCTGCTCCTCAGCTCT
1121 CCACCCCAGGTTGCCTCTCTCCTGTGGGCCTCTGTCTTCTGGGAATAAAGCAGGGTTTCCTACTTCAGGGGATGTAGAGA
1201 GATGCCCAGGTTGCACAGGAGTGGGATGGGGTGTGGTAGCAAAAGGAGGGAGAGGAGTCCTTTTTGTGCCAAATCCCTAA
1281 GTGCCGTTCGGGGGCCATGTGTGCAGCATGACTCTCCCTGTCTGTGGCAGGGACCCAAGCGCTTGCTTAAGCCCCAGTGC
1361 TCCATGCCAGCACTTGAACTGTCTGGGGTTTGATGGACAGAGGCTGAGGAATTTCCTGGCTTCCCCAGATAGTGTCCTGG
1441 GACATGGTATGCTTTGGGGCTGGGGTAGCATGGAATCCCTCTGAGGACCTGGATACTGGTACTACGGGGTGGGGAAGAGG
1521 AACCTTAAACTTGGCTTTCCCCAGCCTTCAGCCTGAGTCTAGCATGTTTCTAGCTCCCCAGTCCCTTGTGAAGCCTTGAG
1601 GGCTGGCAGAAGGGTTAGGAGGTTGAACTCTAGATTCCCTTCCTGTCTTTGCCTTCCTTTTACCCCTTTCCCTGCAACCT
1681 CCTTGACTCTGGCCTGAATTTGTTGGTGCCTCAGTTTCTCTGTCTGTACCTATTTAAGCCAAAGGCACTAGCCTGAATTT
1761 TGCTTGAAGATCACTTTGTCTTGGAAATGACTAGAGAGGCAGAGGAGAAGGGTTTCCAGAGTTGCTAGGTTTGGGAGTGG
1841 AAGGGGCAGGCAGTGCACTTGCCCCTCCTCATGCCCCTTCTGACACCAGCTCCCTGTGGAGGCCTGGTTTCTGGGTAATG
1921 CCTCCCTTGGGCATCTTCATGCATCAACCAAATGGGCCATCAGGTACTTCATTAGTCATGGCAGAAGGAGGGGAAAAGAC
2001 TTGTTTTCCAGACAGAAAATCTACTCCCCTGTCCCCAGCCATATCCCTGGATAGGAAGGGATAGGAAGAGACTACTTGGT
2081 GCCATGGGGTAGGGGTGAGGGTATAAGTAGATCAGAGTGGGAAGACCTCAGCCTTGGGTGGCTTGTCTCTGCTTCTTGCC
2161 AGGTGGGAGGGCCTGTCCACACCCTGGATCCCCGTACCACAGTGCCAGCCATGCCCTTCCCCTGGGCTACCATTGTCCCT
2241 TTCCTCACCCAGTTGGTAGAGGAGTCAGGAGGTGGGAGGCCGTGGGCTTTGGTTTTATAATGTAACCACTGTGGGGGTGG
2321 GGGAGGATGGTGAACCATGTATTTCAGTGAAATATTTAATATATTTAAATATCAATAAAATCAAACTCTTTGTAAAATTC
2401 AAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gauACCCACCCUG-UCUCUCCc 5'
             |||    ||| ||||||| 
Target 5' tctTGGAAATGACTAGAGAGGc 3'
 1779 - 1800 150.00 -15.70
2 
miRNA  3' gauacccacCCUGUCUCUCCc 5'
                   ||| :|||||| 
Target 5' gtagcaaaaGGAGGGAGAGGa 3'
 1236 - 1256 136.00 -15.60
3 
miRNA  3' gauacccaCCCU--GUCUCUCcc 5'
                  ||||  :||||||  
Target 5' tacttcagGGGATGTAGAGAGat 3'
 1181 - 1203 131.00 -13.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30475147 8 COSMIC
COSN26965195 10 COSMIC
COSN30496208 11 COSMIC
COSN30105451 12 COSMIC
COSN30487664 20 COSMIC
COSN31488722 155 COSMIC
COSN31526647 242 COSMIC
COSN16815889 268 COSMIC
COSN23057158 395 COSMIC
COSN30164550 568 COSMIC
COSN30175629 655 COSMIC
COSN31490650 659 COSMIC
COSN8586238 703 COSMIC
COSN31516337 731 COSMIC
COSN1148721 860 COSMIC
COSN1575347 888 COSMIC
COSN26573404 1021 COSMIC
COSN31489344 1114 COSMIC
COSN31522315 1209 COSMIC
COSN1148720 1265 COSMIC
COSN4730038 1425 COSMIC
COSN26564950 1452 COSMIC
COSN25038677 1462 COSMIC
COSN23527723 1505 COSMIC
COSN23169964 1914 COSMIC
COSN32056530 2025 COSMIC
COSN31487125 2095 COSMIC
COSN26561383 2238 COSMIC
COSN22624917 2253 COSMIC
COSN31540102 2261 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1304667620 3 dbSNP
rs747663920 5 dbSNP
rs1432410424 7 dbSNP
rs1357094519 11 dbSNP
rs1332907381 13 dbSNP
rs1046675836 20 dbSNP
rs368177470 23 dbSNP
rs1166708083 24 dbSNP
rs771320108 25 dbSNP
rs754502107 33 dbSNP
rs749813085 35 dbSNP
rs1208852149 36 dbSNP
rs1188078283 37 dbSNP
rs1482369826 42 dbSNP
rs780645206 44 dbSNP
rs1375249024 48 dbSNP
rs1038212407 49 dbSNP
rs1183930694 55 dbSNP
rs1160482727 57 dbSNP
rs942096763 57 dbSNP
rs552374524 62 dbSNP
rs907887317 74 dbSNP
rs1333621048 77 dbSNP
rs1359945220 82 dbSNP
rs1371561935 83 dbSNP
rs207472920 86 dbSNP
rs991189108 102 dbSNP
rs1443561396 103 dbSNP
rs1359155723 108 dbSNP
rs1174340907 109 dbSNP
rs938443879 111 dbSNP
rs3729973 121 dbSNP
rs1430111768 126 dbSNP
rs933319106 127 dbSNP
rs971850482 135 dbSNP
rs974618401 140 dbSNP
rs1202076092 141 dbSNP
rs1250633855 144 dbSNP
rs750292370 149 dbSNP
rs961817261 150 dbSNP
rs1477356187 154 dbSNP
rs552533168 154 dbSNP
rs1178796962 155 dbSNP
rs1166870495 161 dbSNP
rs147963105 177 dbSNP
rs369475047 188 dbSNP
rs867038902 189 dbSNP
rs546911280 191 dbSNP
rs527658229 192 dbSNP
rs965415599 197 dbSNP
rs185638739 201 dbSNP
rs1273416094 210 dbSNP
rs1227330385 214 dbSNP
rs1206290772 215 dbSNP
rs1002574368 222 dbSNP
rs548420974 224 dbSNP
rs1224737696 233 dbSNP
rs1198855461 237 dbSNP
rs1025256432 245 dbSNP
rs903002279 246 dbSNP
rs1379044921 247 dbSNP
rs1479024048 250 dbSNP
rs1186776539 253 dbSNP
rs1389754998 254 dbSNP
rs1430687456 283 dbSNP
rs1170246159 286 dbSNP
rs1388379185 289 dbSNP
rs144955011 292 dbSNP
rs1011494121 294 dbSNP
rs1324051736 301 dbSNP
rs1332793335 303 dbSNP
rs894437666 308 dbSNP
rs942110709 312 dbSNP
rs562760135 315 dbSNP
rs1230252070 334 dbSNP
rs1354623160 340 dbSNP
rs1209648269 346 dbSNP
rs1291155049 347 dbSNP
rs1047794915 348 dbSNP
rs1186716316 351 dbSNP
rs1247561512 361 dbSNP
rs938316144 361 dbSNP
rs765487255 363 dbSNP
rs923255981 381 dbSNP
rs558414845 382 dbSNP
rs943271285 383 dbSNP
rs1392768196 387 dbSNP
rs1455615624 394 dbSNP
rs1365821845 402 dbSNP
rs1388809812 403 dbSNP
rs1436666783 403 dbSNP
rs1310080982 412 dbSNP
rs940480657 422 dbSNP
rs908707577 423 dbSNP
rs1244485901 433 dbSNP
rs1285195733 435 dbSNP
rs914393892 443 dbSNP
rs776804652 448 dbSNP
rs990040171 449 dbSNP
rs984291876 455 dbSNP
rs371908452 456 dbSNP
rs1384408836 464 dbSNP
rs952883430 489 dbSNP
rs921483266 494 dbSNP
rs956059272 498 dbSNP
rs1181622409 502 dbSNP
rs1187964347 503 dbSNP
rs1370044965 511 dbSNP
rs1471563653 513 dbSNP
rs1462604570 519 dbSNP
rs924385946 536 dbSNP
rs975705336 538 dbSNP
rs546109718 543 dbSNP
rs1019636134 545 dbSNP
rs1204101126 548 dbSNP
rs1022610196 552 dbSNP
rs757103955 561 dbSNP
rs1484678015 566 dbSNP
rs1335272305 570 dbSNP
rs1357685393 574 dbSNP
rs967492061 583 dbSNP
rs1226959211 596 dbSNP
rs1021467070 602 dbSNP
rs761285941 604 dbSNP
rs1262166678 606 dbSNP
rs1216106041 607 dbSNP
rs773572285 614 dbSNP
rs1241233970 619 dbSNP
rs1321447446 621 dbSNP
rs1313393527 624 dbSNP
rs1011377624 625 dbSNP
rs1259877043 634 dbSNP
rs1481915390 638 dbSNP
rs753611531 645 dbSNP
rs545950008 648 dbSNP
rs368638446 650 dbSNP
rs1420861401 651 dbSNP
rs894324936 657 dbSNP
rs1376643670 662 dbSNP
rs1056091698 676 dbSNP
rs1162985168 679 dbSNP
rs1173909739 685 dbSNP
rs1368339536 689 dbSNP
rs577124342 691 dbSNP
rs1384269330 692 dbSNP
rs1307851144 694 dbSNP
rs1016923623 695 dbSNP
rs1393703898 700 dbSNP
rs906849915 701 dbSNP
rs1311606174 702 dbSNP
rs1036061830 703 dbSNP
rs1234068692 706 dbSNP
rs1282672649 719 dbSNP
rs1340359822 721 dbSNP
rs1204154173 722 dbSNP
rs940441062 723 dbSNP
rs908924989 735 dbSNP
rs1048805797 745 dbSNP
rs1266607362 747 dbSNP
rs931453758 752 dbSNP
rs1194989745 754 dbSNP
rs1387904377 761 dbSNP
rs1428760208 764 dbSNP
rs1168338165 767 dbSNP
rs1371630384 769 dbSNP
rs921451994 772 dbSNP
rs772547425 788 dbSNP
rs560496564 804 dbSNP
rs1463853804 807 dbSNP
rs540518067 808 dbSNP
rs1289623643 811 dbSNP
rs574386572 812 dbSNP
rs912548886 819 dbSNP
rs575818585 825 dbSNP
rs1228032207 834 dbSNP
rs1298616660 843 dbSNP
rs1308979301 852 dbSNP
rs56009129 853 dbSNP
rs148713267 854 dbSNP
rs1038996897 856 dbSNP
rs74512157 857 dbSNP
rs990250093 870 dbSNP
rs1190069791 879 dbSNP
rs914529024 885 dbSNP
rs1188723662 895 dbSNP
rs958506793 897 dbSNP
rs1034213467 911 dbSNP
rs1430611421 915 dbSNP
rs1163153797 917 dbSNP
rs1426181156 928 dbSNP
rs1349791538 930 dbSNP
rs1462485234 938 dbSNP
rs1003195481 954 dbSNP
rs1386461283 956 dbSNP
rs1434484146 963 dbSNP
rs1263250114 964 dbSNP
rs1298549351 972 dbSNP
rs7961282 978 dbSNP
rs1226368368 987 dbSNP
rs1490085554 992 dbSNP
rs558785713 1024 dbSNP
rs768244916 1025 dbSNP
rs1235131432 1026 dbSNP
rs748824361 1027 dbSNP
rs971104508 1028 dbSNP
rs915563284 1033 dbSNP
rs575573725 1035 dbSNP
rs887458778 1041 dbSNP
rs1243446099 1044 dbSNP
rs1482101732 1050 dbSNP
rs1225915426 1053 dbSNP
rs1180470100 1054 dbSNP
rs1413612570 1056 dbSNP
rs1475743353 1057 dbSNP
rs1328221212 1062 dbSNP
rs1167661152 1069 dbSNP
rs779576470 1079 dbSNP
rs1410430822 1080 dbSNP
rs1456738653 1080 dbSNP
rs1048775619 1088 dbSNP
rs1386424735 1095 dbSNP
rs34681523 1096 dbSNP
rs374587953 1126 dbSNP
rs1446163922 1130 dbSNP
rs1343938747 1135 dbSNP
rs1301043391 1137 dbSNP
rs1426362986 1145 dbSNP
rs1016543622 1148 dbSNP
rs1286325166 1152 dbSNP
rs1328426561 1155 dbSNP
rs1365998393 1159 dbSNP
rs931756381 1163 dbSNP
rs1285819210 1176 dbSNP
rs1310073648 1186 dbSNP
rs538879818 1193 dbSNP
rs1374227457 1198 dbSNP
rs1039909114 1204 dbSNP
rs944287349 1215 dbSNP
rs912776717 1230 dbSNP
rs1472579917 1231 dbSNP
rs557279546 1232 dbSNP
rs1202000738 1233 dbSNP
rs1410340668 1233 dbSNP
rs1026411797 1239 dbSNP
rs977679108 1250 dbSNP
rs997563850 1252 dbSNP
rs1349788088 1263 dbSNP
rs1490603213 1277 dbSNP
rs566658684 1285 dbSNP
rs150009601 1286 dbSNP
rs1194521673 1288 dbSNP
rs536524480 1289 dbSNP
rs1349650857 1290 dbSNP
rs990217358 1290 dbSNP
rs1223040599 1296 dbSNP
rs1321639082 1297 dbSNP
rs537558592 1298 dbSNP
rs1183080226 1301 dbSNP
rs1285390155 1312 dbSNP
rs755554025 1316 dbSNP
rs56258492 1324 dbSNP
rs1477052065 1328 dbSNP
rs1190714926 1335 dbSNP
rs1405807669 1340 dbSNP
rs1395882310 1341 dbSNP
rs958809096 1342 dbSNP
rs139309787 1359 dbSNP
rs1034594837 1361 dbSNP
rs981258372 1373 dbSNP
rs1330756357 1377 dbSNP
rs758632634 1380 dbSNP
rs1348085617 1388 dbSNP
rs893109286 1396 dbSNP
rs1054398509 1398 dbSNP
rs545854465 1402 dbSNP
rs55708807 1408 dbSNP
rs903028337 1411 dbSNP
rs1167965183 1420 dbSNP
rs1045548848 1423 dbSNP
rs370709558 1424 dbSNP
rs531722220 1425 dbSNP
rs60640368 1437 dbSNP
rs745874328 1449 dbSNP
rs949859557 1450 dbSNP
rs1426627520 1452 dbSNP
rs568963907 1457 dbSNP
rs566976251 1459 dbSNP
rs1450431944 1460 dbSNP
rs1178081655 1464 dbSNP
rs552251224 1475 dbSNP
rs1253784117 1478 dbSNP
rs1044574 1481 dbSNP
rs1455647356 1489 dbSNP
rs1004775806 1505 dbSNP
rs887426137 1506 dbSNP
rs1389811407 1529 dbSNP
rs1027306828 1535 dbSNP
rs991632089 1539 dbSNP
rs941060197 1541 dbSNP
rs1388461081 1555 dbSNP
rs879249124 1565 dbSNP
rs1325988852 1575 dbSNP
rs1180184018 1576 dbSNP
rs141933511 1586 dbSNP
rs900291962 1594 dbSNP
rs1251923796 1602 dbSNP
rs1040531351 1614 dbSNP
rs1319409129 1618 dbSNP
rs1326686339 1620 dbSNP
rs1203623654 1629 dbSNP
rs1459998967 1631 dbSNP
rs1265096505 1640 dbSNP
rs1228570961 1642 dbSNP
rs944187975 1643 dbSNP
rs1189766910 1649 dbSNP
rs532608288 1657 dbSNP
rs1354840833 1674 dbSNP
rs891305462 1677 dbSNP
rs560301570 1688 dbSNP
rs1469843780 1693 dbSNP
rs1206943559 1695 dbSNP
rs1350317750 1698 dbSNP
rs1447852199 1702 dbSNP
rs1026521523 1706 dbSNP
rs1366570646 1707 dbSNP
rs1472345911 1710 dbSNP
rs1236677878 1713 dbSNP
rs1337428328 1715 dbSNP
rs1419963797 1716 dbSNP
rs540600324 1718 dbSNP
rs1157821235 1724 dbSNP
rs1385195748 1726 dbSNP
rs966170898 1739 dbSNP
rs914567217 1740 dbSNP
rs530394248 1752 dbSNP
rs1403191289 1753 dbSNP
rs990187913 1762 dbSNP
rs1339019215 1777 dbSNP
rs146231750 1780 dbSNP
rs1294405195 1783 dbSNP
rs1469987574 1794 dbSNP
rs1337638619 1799 dbSNP
rs192676519 1828 dbSNP
rs1260278458 1837 dbSNP
rs1351668031 1844 dbSNP
rs1207048906 1849 dbSNP
rs1254351680 1854 dbSNP
rs893150967 1855 dbSNP
rs140559205 1860 dbSNP
rs1259483683 1874 dbSNP
rs575305400 1875 dbSNP
rs971231949 1877 dbSNP
rs1364763515 1884 dbSNP
rs1363940907 1886 dbSNP
rs998777115 1894 dbSNP
rs1170397991 1898 dbSNP
rs1401097771 1915 dbSNP
rs1183458202 1924 dbSNP
rs903138388 1925 dbSNP
rs187444340 1933 dbSNP
rs1357903476 1941 dbSNP
rs1443335076 1944 dbSNP
rs572322986 1956 dbSNP
rs983318454 1957 dbSNP
rs1306922736 1963 dbSNP
rs894280069 1966 dbSNP
rs757078292 1969 dbSNP
rs1254443065 1970 dbSNP
rs183152956 1971 dbSNP
rs1282268625 1976 dbSNP
rs1282468049 1977 dbSNP
rs909557513 1979 dbSNP
rs190693682 1991 dbSNP
rs374102645 1994 dbSNP
rs982373169 1997 dbSNP
rs1352509915 2004 dbSNP
rs1196185926 2011 dbSNP
rs1309727787 2013 dbSNP
rs1454488909 2015 dbSNP
rs1245066814 2019 dbSNP
rs1377584459 2020 dbSNP
rs1428236077 2025 dbSNP
rs1380575129 2027 dbSNP
rs1316512041 2039 dbSNP
rs1393180806 2043 dbSNP
rs553175196 2057 dbSNP
rs929637009 2059 dbSNP
rs1018669711 2061 dbSNP
rs1305902425 2064 dbSNP
rs1339751320 2067 dbSNP
rs1203601021 2071 dbSNP
rs1009085264 2072 dbSNP
rs1481606588 2074 dbSNP
rs1207537773 2078 dbSNP
rs891280481 2079 dbSNP
rs1468544033 2082 dbSNP
rs1195051925 2083 dbSNP
rs1427065878 2084 dbSNP
rs1041940184 2092 dbSNP
rs536169838 2093 dbSNP
rs759964642 2099 dbSNP
rs1163422775 2103 dbSNP
rs1393740395 2110 dbSNP
rs893353328 2111 dbSNP
rs1328127917 2116 dbSNP
rs1363344799 2119 dbSNP
rs1387685627 2120 dbSNP
rs1213753290 2125 dbSNP
rs1296099903 2126 dbSNP
rs1184251403 2127 dbSNP
rs1475102578 2129 dbSNP
rs1240451220 2133 dbSNP
rs1033090234 2146 dbSNP
rs998888339 2148 dbSNP
rs1195519586 2153 dbSNP
rs1215053740 2159 dbSNP
rs942709425 2164 dbSNP
rs1054720078 2182 dbSNP
rs567512112 2183 dbSNP
rs927305008 2193 dbSNP
rs1045799002 2194 dbSNP
rs554669692 2196 dbSNP
rs894320803 2199 dbSNP
rs1357155068 2201 dbSNP
rs538284867 2213 dbSNP
rs1167256164 2214 dbSNP
rs1343643869 2230 dbSNP
rs1430362651 2235 dbSNP
rs1228845308 2238 dbSNP
rs1360597067 2242 dbSNP
rs755210753 2243 dbSNP
rs907706807 2244 dbSNP
rs1267903475 2260 dbSNP
rs1363745665 2264 dbSNP
rs1394095221 2273 dbSNP
rs71464931 2279 dbSNP
rs373941978 2281 dbSNP
rs754083103 2288 dbSNP
rs767064246 2300 dbSNP
rs920480122 2301 dbSNP
rs1432455955 2306 dbSNP
rs1315956783 2311 dbSNP
rs568902692 2313 dbSNP
rs1262135306 2319 dbSNP
rs1487024282 2322 dbSNP
rs964389325 2327 dbSNP
rs1186306610 2328 dbSNP
rs1302903259 2336 dbSNP
rs1403530937 2338 dbSNP
rs1257411840 2346 dbSNP
rs1367883814 2347 dbSNP
rs1475855658 2355 dbSNP
rs888227076 2357 dbSNP
rs1405797350 2359 dbSNP
rs1019054111 2380 dbSNP
rs1464885086 2383 dbSNP
rs1160043045 2391 dbSNP
rs1347209602 2395 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gauacccacCCUGUCUCUCCc 5'
                   ||| :|||||| 
Target 5' -----aaaaGGAGGGAGAGGa 3'
 		1 - 16
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000357869.3 | 3UTR | AAAAGGAGGGAGAGGAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
209 hsa-miR-6769b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT181753 UHMK1 U2AF homology motif kinase 1 2 2
MIRT287119 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT395372 CDC42EP4 CDC42 effector protein 4 2 4
MIRT472533 NACC1 nucleus accumbens associated 1 2 4
MIRT472611 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT482405 ADRB1 adrenoceptor beta 1 2 10
MIRT492330 SETD1B SET domain containing 1B 2 2
MIRT499238 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT512274 ARHGDIA Rho GDP dissociation inhibitor alpha 2 6
MIRT534548 RUNX1 runt related transcription factor 1 2 2
MIRT535374 PEX5L peroxisomal biogenesis factor 5 like 2 2
MIRT535424 PDZD8 PDZ domain containing 8 2 2
MIRT539329 AHSA2 activator of HSP90 ATPase homolog 2 2 4
MIRT569350 EFHC1 EF-hand domain containing 1 2 2
MIRT576116 Klf6 Kruppel-like factor 6 2 2
MIRT607241 LINS lines homolog 1 2 4
MIRT607364 ASAH2 N-acylsphingosine amidohydrolase 2 2 4
MIRT609572 CATSPER4 cation channel sperm associated 4 2 2
MIRT610045 SERPINA3 serpin family A member 3 2 2
MIRT610284 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT610302 KLHL21 kelch like family member 21 2 2
MIRT610393 FOXE1 forkhead box E1 2 2
MIRT610432 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT610510 BARHL2 BarH like homeobox 2 2 2
MIRT611818 FCRL4 Fc receptor like 4 2 2
MIRT612755 MYOCD myocardin 2 2
MIRT613698 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613917 POU3F1 POU class 3 homeobox 1 2 2
MIRT615153 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 2
MIRT615201 CLUAP1 clusterin associated protein 1 2 2
MIRT615338 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT616706 UBXN2A UBX domain protein 2A 2 2
MIRT617186 GOSR2 golgi SNAP receptor complex member 2 2 4
MIRT617526 SORCS2 sortilin related VPS10 domain containing receptor 2 2 2
MIRT617596 NUDT5 nudix hydrolase 5 2 4
MIRT617763 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT618613 SHOX short stature homeobox 2 2
MIRT619301 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619515 TXLNB taxilin beta 2 2
MIRT619925 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT619942 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT620025 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT620554 C10orf10 chromosome 10 open reading frame 10 2 4
MIRT620752 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT621798 TMEM233 transmembrane protein 233 2 2
MIRT621843 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT622693 PLSCR1 phospholipid scramblase 1 2 2
MIRT622733 PITPNM3 PITPNM family member 3 2 2
MIRT623004 ONECUT3 one cut homeobox 3 2 2
MIRT623211 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT623771 GPR37L1 G protein-coupled receptor 37 like 1 2 2
MIRT624119 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT624150 DIAPH1 diaphanous related formin 1 2 2
MIRT624443 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT624855 ABI2 abl interactor 2 2 2
MIRT625311 SHISA6 shisa family member 6 2 2
MIRT625741 MTSS1 MTSS1, I-BAR domain containing 2 2
MIRT626292 ZNF85 zinc finger protein 85 2 2
MIRT627400 TMEM170A transmembrane protein 170A 2 2
MIRT627464 SYNRG synergin gamma 2 2
MIRT627913 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT636508 GDAP1L1 ganglioside induced differentiation associated protein 1 like 1 2 2
MIRT636910 KIAA0408 KIAA0408 2 2
MIRT637302 ACTN2 actinin alpha 2 2 2
MIRT638230 SOGA3 SOGA family member 3 2 2
MIRT639880 STC1 stanniocalcin 1 2 2
MIRT639999 PHF21B PHD finger protein 21B 2 2
MIRT640149 CEP104 centrosomal protein 104 2 2
MIRT640699 SKI SKI proto-oncogene 2 2
MIRT640911 RAB13 RAB13, member RAS oncogene family 2 2
MIRT641518 CREBBP CREB binding protein 2 2
MIRT641990 OXSR1 oxidative stress responsive 1 2 2
MIRT642635 EPPIN epididymal peptidase inhibitor 2 2
MIRT642744 TDRD6 tudor domain containing 6 2 2
MIRT642759 SDHAF2 succinate dehydrogenase complex assembly factor 2 2 2
MIRT642787 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2 2
MIRT643054 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643104 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT643316 TMEM151B transmembrane protein 151B 2 2
MIRT643715 ITK IL2 inducible T-cell kinase 2 2
MIRT644087 A4GALT alpha 1,4-galactosyltransferase (P blood group) 2 2
MIRT644112 SEL1L3 SEL1L family member 3 2 2
MIRT644377 ZNF286A zinc finger protein 286A 2 2
MIRT644408 FRMD6 FERM domain containing 6 2 2
MIRT644684 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT644744 CCDC174 coiled-coil domain containing 174 2 2
MIRT644876 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT645417 FAM110A family with sequence similarity 110 member A 2 2
MIRT645928 PLXNA3 plexin A3 2 2
MIRT646181 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT646554 TMCC2 transmembrane and coiled-coil domain family 2 2 2
MIRT647235 OR6A2 olfactory receptor family 6 subfamily A member 2 2 2
MIRT647263 PTGDR2 prostaglandin D2 receptor 2 2 2
MIRT647660 FOXL1 forkhead box L1 2 2
MIRT648284 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT648493 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT648963 TMEM45B transmembrane protein 45B 2 2
MIRT649511 RAB17 RAB17, member RAS oncogene family 2 2
MIRT650446 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650712 KRT32 keratin 32 2 2
MIRT651069 ZNF518B zinc finger protein 518B 2 4
MIRT651090 ZNF516 zinc finger protein 516 2 2
MIRT651193 ZNF281 zinc finger protein 281 2 2
MIRT651330 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT651445 XKR4 XK related 4 2 2
MIRT651517 WNT4 Wnt family member 4 2 4
MIRT651694 VPS13D vacuolar protein sorting 13 homolog D 2 2
MIRT652173 TRIM66 tripartite motif containing 66 2 2
MIRT652432 TMEM239 transmembrane protein 239 2 2
MIRT652656 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT652707 THBS2 thrombospondin 2 2 2
MIRT652812 TBL2 transducin beta like 2 2 2
MIRT653350 SMG7 SMG7, nonsense mediated mRNA decay factor 2 2
MIRT653471 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT653658 SLC27A4 solute carrier family 27 member 4 2 2
MIRT654691 PSMB5 proteasome subunit beta 5 2 2
MIRT654735 PRLR prolactin receptor 2 2
MIRT654931 POLR3D RNA polymerase III subunit D 2 2
MIRT655209 PHAX phosphorylated adaptor for RNA export 2 2
MIRT655346 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT655404 PANK1 pantothenate kinase 1 2 2
MIRT655482 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT655964 NDNF neuron derived neurotrophic factor 2 2
MIRT656017 MYPN myopalladin 2 2
MIRT656491 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657151 ITGA1 integrin subunit alpha 1 2 2
MIRT657411 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 2
MIRT657608 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT658181 FBXO9 F-box protein 9 2 2
MIRT658932 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT659028 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659092 DENR density regulated re-initiation and release factor 2 2
MIRT659204 CYBB cytochrome b-245 beta chain 2 2
MIRT659718 CCDC93 coiled-coil domain containing 93 2 2
MIRT660185 BNC2 basonuclin 2 2 2
MIRT660805 AIFM2 apoptosis inducing factor, mitochondria associated 2 2 2
MIRT660900 ADCY6 adenylate cyclase 6 2 2
MIRT660925 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT661741 DTHD1 death domain containing 1 2 2
MIRT661998 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT662639 PKHD1L1 PKHD1 like 1 2 2
MIRT664338 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT666743 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT667070 PANK3 pantothenate kinase 3 2 2
MIRT667925 IGLON5 IgLON family member 5 2 2
MIRT668488 ETV3 ETS variant 3 2 2
MIRT668610 EHD4 EH domain containing 4 2 2
MIRT669419 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT669652 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT674005 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT680447 SLCO5A1 solute carrier organic anion transporter family member 5A1 2 2
MIRT684326 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT685625 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT689978 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT693962 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT698543 TFRC transferrin receptor 2 2
MIRT699982 RREB1 ras responsive element binding protein 1 2 2
MIRT702898 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT707383 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT708312 CDH8 cadherin 8 2 2
MIRT708406 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT709299 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT710326 STK40 serine/threonine kinase 40 2 2
MIRT710729 C19orf68 zinc finger SWIM-type containing 9 2 2
MIRT710970 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT711178 EMCN endomucin 2 2
MIRT711590 SETD1A SET domain containing 1A 2 2
MIRT711611 LHX5 LIM homeobox 5 2 2
MIRT711701 GMPR guanosine monophosphate reductase 2 2
MIRT711850 AMOTL2 angiomotin like 2 2 2
MIRT712358 NAT14 N-acetyltransferase 14 (putative) 2 2
MIRT712377 MTPN myotrophin 2 2
MIRT712469 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT712839 RHOA ras homolog family member A 2 2
MIRT713592 ANKMY1 ankyrin repeat and MYND domain containing 1 2 2
MIRT713982 ASIC4 acid sensing ion channel subunit family member 4 2 2
MIRT714534 ZBTB39 zinc finger and BTB domain containing 39 2 2
MIRT714570 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT714610 EXO5 exonuclease 5 2 2
MIRT714943 ZNF330 zinc finger protein 330 2 2
MIRT715132 ACADL acyl-CoA dehydrogenase, long chain 2 2
MIRT716018 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT716204 TYW3 tRNA-yW synthesizing protein 3 homolog 2 2
MIRT716674 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT717366 EDN2 endothelin 2 2 2
MIRT718110 CRTC1 CREB regulated transcription coactivator 1 2 2
MIRT718502 GYS1 glycogen synthase 1 2 2
MIRT719146 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719415 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT719986 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT720347 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT720452 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720493 TMEM178B transmembrane protein 178B 2 2
MIRT720666 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT721091 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT721334 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT721384 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT721508 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721827 POU6F1 POU class 6 homeobox 1 2 2
MIRT722136 TTLL11 tubulin tyrosine ligase like 11 2 2
MIRT723070 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723115 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT723374 ZNF470 zinc finger protein 470 2 2
MIRT724446 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT724528 ATP2B1 ATPase plasma membrane Ca2+ transporting 1 2 2
MIRT724643 PKDREJ polycystin family receptor for egg jelly 2 2
MIRT724711 CRAMP1L cramped chromatin regulator homolog 1 2 2
MIRT724750 ZNF391 zinc finger protein 391 2 2
MIRT724770 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6769b Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-6769b Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-6769b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-6769b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-6769b-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

Error report submission