pre-miRNA Information
pre-miRNA hsa-mir-6871   
Genomic Coordinates chr20: 41169023 - 41169078
Description Homo sapiens miR-6871 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6871-3p
Sequence 35| CAGCACCCUGUGGCUCCCACAG |56
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN16670239 4 COSMIC
COSN1872096 9 COSMIC
COSM1741616 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs545076040 1 dbSNP
rs1273348199 2 dbSNP
rs1202373059 5 dbSNP
rs1340707970 7 dbSNP
rs372994756 8 dbSNP
rs869070782 15 dbSNP
rs931272568 16 dbSNP
rs1333765165 18 dbSNP
Putative Targets

Gene Information
Gene Symbol EPHX2   
Synonyms CEH, SEH
Description epoxide hydrolase 2
Transcript NM_001979   
Expression
Putative miRNA Targets on EPHX2
3'UTR of EPHX2
(miRNA target sites are highlighted)
>EPHX2|NM_001979|3'UTR
   1 AACGCAGCGTGTGCCCACGCTCAGCAGGTGTGCCATCCTTCCACCTGCTGGGGCACCATTCTTAGTATACAGAGGTGGCC
  81 TTACACACATCTTGCATGGATGGCAGCATTGTTCTGAAGGGGTTTGCAGAAAAAAAAGATTTTCTTTACATAAAGTGAAT
 161 CAAATTTGACATTATTTTAGATCCCAGAGAAATCAGGTGTGATTAGTTCTCCAGGCATGAATGCATCGTCCCTTTATCTG
 241 TAAGAACCCTTAGTGTCCTGTAGGGGGACAGAATGGGGTGGCCAGGTGGTGATTTCTCTTTGACCAATGCATAGTTTGGC
 321 AGAAAAATCAGCCGTTCATTTAGAAGAATCTTAGCAGAGATTGGGATGCCTTACTCAATAAAGCTAAGATGACTATGCTG
 401 AAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaCA-CCCUCGG---UGUCCCACgac 5'
            || |||:| |   |::|||||   
Target 5' ctGTAGGGGGACAGAATGGGGTGgcc 3'
258 - 283 120.00 -21.02
2
miRNA  3' gaCACCC---U-CG-GU-GUCC-CACGac 5'
            ||| |   | || || |||| ||||  
Target 5' gcGTGTGCCCACGCTCAGCAGGTGTGCca 3'
7 - 35 104.00 -16.70
3
miRNA  3' gacACCCUCGGUGUCCC-ACGac 5'
             | | ||  |: ||| |||  
Target 5' tctTAGCAGAGATTGGGATGCct 3'
349 - 371 99.00 -10.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26678383 8 COSMIC
COSN30529591 10 COSMIC
COSN30100872 19 COSMIC
COSN30159491 20 COSMIC
COSN9629997 26 COSMIC
COSN28794011 36 COSMIC
COSN31507879 51 COSMIC
COSN28709936 94 COSMIC
COSN30167122 101 COSMIC
COSN30151088 117 COSMIC
COSN28846980 138 COSMIC
COSN31506130 140 COSMIC
COSN30120621 145 COSMIC
COSN27300814 429 COSMIC
COSN25756837 821 COSMIC
COSN22925934 840 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs370038028 4 dbSNP
rs201671681 5 dbSNP
rs962523315 8 dbSNP
rs375593102 9 dbSNP
rs369372219 10 dbSNP
rs529710398 12 dbSNP
rs749303575 14 dbSNP
rs199902688 19 dbSNP
rs746160691 20 dbSNP
rs768382199 21 dbSNP
rs776419985 23 dbSNP
rs1361491045 27 dbSNP
rs766178696 35 dbSNP
rs1042032 36 dbSNP
rs1318621012 37 dbSNP
rs1222998252 38 dbSNP
rs773253379 43 dbSNP
rs1157164456 44 dbSNP
rs201934064 45 dbSNP
rs1211939566 46 dbSNP
rs532790832 47 dbSNP
rs751110951 53 dbSNP
rs1364590384 67 dbSNP
rs1180744374 68 dbSNP
rs185514308 69 dbSNP
rs913856988 72 dbSNP
rs945256267 75 dbSNP
rs1043776545 78 dbSNP
rs1252472584 85 dbSNP
rs1042064 94 dbSNP
rs1265070362 99 dbSNP
rs1292021973 104 dbSNP
rs144328663 107 dbSNP
rs538556998 110 dbSNP
rs1309448418 117 dbSNP
rs973105628 120 dbSNP
rs1055579529 122 dbSNP
rs896660604 125 dbSNP
rs1198678604 129 dbSNP
rs1368088310 130 dbSNP
rs1302037464 133 dbSNP
rs1436626579 140 dbSNP
rs1446813548 142 dbSNP
rs1013741352 146 dbSNP
rs112744942 149 dbSNP
rs1378111921 152 dbSNP
rs1316917625 156 dbSNP
rs1400437722 158 dbSNP
rs1479072230 161 dbSNP
rs1156931623 181 dbSNP
rs1361602735 198 dbSNP
rs1026439504 201 dbSNP
rs754835910 203 dbSNP
rs1394746053 207 dbSNP
rs988099157 210 dbSNP
rs950992846 212 dbSNP
rs56187906 215 dbSNP
rs533997343 217 dbSNP
rs113816395 221 dbSNP
rs1364169176 226 dbSNP
rs554282739 228 dbSNP
rs72478910 229 dbSNP
rs15520 239 dbSNP
rs538855549 241 dbSNP
rs962670812 242 dbSNP
rs1286504446 252 dbSNP
rs369196685 254 dbSNP
rs1345258209 260 dbSNP
rs778573660 261 dbSNP
rs946798014 264 dbSNP
rs1369125546 265 dbSNP
rs1333300309 266 dbSNP
rs955146044 268 dbSNP
rs986654793 270 dbSNP
rs1277282105 271 dbSNP
rs1268888115 272 dbSNP
rs558413926 281 dbSNP
rs913722693 287 dbSNP
rs945288831 289 dbSNP
rs747967822 297 dbSNP
rs1349257460 307 dbSNP
rs1240513650 311 dbSNP
rs1177071974 320 dbSNP
rs1287707175 326 dbSNP
rs905166781 328 dbSNP
rs937295016 330 dbSNP
rs1244597404 332 dbSNP
rs1043639730 334 dbSNP
rs112182784 335 dbSNP
rs1195573630 342 dbSNP
rs1484603226 347 dbSNP
rs937975980 350 dbSNP
rs1055126234 351 dbSNP
rs1210398419 365 dbSNP
rs1005159955 367 dbSNP
rs1313386023 379 dbSNP
rs1267741488 384 dbSNP
rs1453279940 387 dbSNP
rs758383869 392 dbSNP
rs896602573 396 dbSNP
rs1013607126 401 dbSNP
rs544119405 402 dbSNP
rs1319203319 408 dbSNP
rs1014758266 410 dbSNP
rs200503210 414 dbSNP
rs777662194 418 dbSNP
rs1047913418 424 dbSNP
rs886582718 426 dbSNP
rs1160739381 428 dbSNP
rs1006448103 434 dbSNP
rs544565063 440 dbSNP
rs962416105 443 dbSNP
rs1169790902 451 dbSNP
rs774616685 453 dbSNP
rs953001833 454 dbSNP
rs4149259 456 dbSNP
rs575746606 457 dbSNP
rs1182280236 458 dbSNP
rs986517503 464 dbSNP
rs1230886937 466 dbSNP
rs1203189077 480 dbSNP
rs956967961 484 dbSNP
rs1334722805 491 dbSNP
rs61607222 493 dbSNP
rs1454283003 495 dbSNP
rs1311052948 496 dbSNP
rs915369274 500 dbSNP
rs769992945 506 dbSNP
rs946807801 507 dbSNP
rs979380830 510 dbSNP
rs980801329 512 dbSNP
rs189089713 515 dbSNP
rs1333225062 516 dbSNP
rs937939852 527 dbSNP
rs1056462644 528 dbSNP
rs895761449 534 dbSNP
rs543124961 535 dbSNP
rs1177641421 540 dbSNP
rs1439722483 544 dbSNP
rs1211322311 549 dbSNP
rs917913341 549 dbSNP
rs1488426890 551 dbSNP
rs1266603785 563 dbSNP
rs898970297 569 dbSNP
rs1315508096 574 dbSNP
rs1306483801 575 dbSNP
rs147356309 576 dbSNP
rs1358117699 580 dbSNP
rs1379452247 581 dbSNP
rs994606668 584 dbSNP
rs1028770638 588 dbSNP
rs546346616 589 dbSNP
rs1389922561 598 dbSNP
rs888854275 602 dbSNP
rs1272185888 607 dbSNP
rs1009013286 621 dbSNP
rs181543461 624 dbSNP
rs1157633242 625 dbSNP
rs4149260 626 dbSNP
rs1381832043 633 dbSNP
rs1191189513 637 dbSNP
rs774971862 642 dbSNP
rs988373188 656 dbSNP
rs1193435805 660 dbSNP
rs1022430203 664 dbSNP
rs886613983 665 dbSNP
rs1217876145 683 dbSNP
rs1356111470 684 dbSNP
rs762374287 685 dbSNP
rs527840165 695 dbSNP
rs1233576788 703 dbSNP
rs1188431875 706 dbSNP
rs77781664 726 dbSNP
rs1301837904 728 dbSNP
rs7341557 739 dbSNP
rs1359829775 740 dbSNP
rs1297331051 745 dbSNP
rs1400445944 747 dbSNP
rs939450646 763 dbSNP
rs1171366080 769 dbSNP
rs753319834 772 dbSNP
rs1377717502 776 dbSNP
rs1178814430 785 dbSNP
rs1473630936 793 dbSNP
rs908505351 796 dbSNP
rs1167900564 799 dbSNP
rs996428082 806 dbSNP
rs1028417628 807 dbSNP
rs1194844933 809 dbSNP
rs890770321 816 dbSNP
rs1401623058 824 dbSNP
rs527732918 826 dbSNP
rs1255602317 827 dbSNP
rs1467608489 837 dbSNP
rs1332820511 838 dbSNP
rs1165812109 840 dbSNP
rs547550442 846 dbSNP
rs1257803812 847 dbSNP
rs1225399012 848 dbSNP
rs1020682663 853 dbSNP
rs1315974849 865 dbSNP
rs966442020 866 dbSNP
rs1400311421 879 dbSNP
rs1451466181 882 dbSNP
rs1342154760 885 dbSNP
rs979714837 891 dbSNP
rs1395120184 905 dbSNP
rs1402515433 922 dbSNP
rs1036257057 936 dbSNP
rs920492238 937 dbSNP
rs1172031919 939 dbSNP
rs1423456390 939 dbSNP
rs1478980299 940 dbSNP
rs1032158130 944 dbSNP
rs959581293 949 dbSNP
rs1443193524 956 dbSNP
rs1258601110 966 dbSNP
rs747916730 971 dbSNP
rs888901225 975 dbSNP
rs11989325 976 dbSNP
rs892098756 981 dbSNP
rs1243871716 987 dbSNP
rs1009172578 991 dbSNP
rs1314441939 995 dbSNP
rs1443866551 998 dbSNP
rs1398950864 999 dbSNP
rs1318550876 1000 dbSNP
rs1012681576 1004 dbSNP
rs1467616474 1004 dbSNP
rs1200403388 1006 dbSNP
rs185592412 1007 dbSNP
rs1163026935 1009 dbSNP
rs1261348123 1010 dbSNP
rs1370346336 1011 dbSNP
rs917937426 1014 dbSNP
rs539564729 1015 dbSNP
rs1200639997 1020 dbSNP
rs1459014541 1021 dbSNP
rs1208951993 1025 dbSNP
rs190050446 1037 dbSNP
rs1266798124 1039 dbSNP
rs1258509195 1041 dbSNP
rs1427150987 1042 dbSNP
rs1309325738 1043 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gacacccucggugucCCACGac 5'
                         |||||  
Target 5' gaaagagaagggggaGGUGC-- 3'
13 - 32
2
miRNA  3' gacacccucggugUCCCACgac 5'
                       |||| |   
Target 5' ----------aggAGGGAGaga 3'
1 - 12
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000521400.1 | 3UTR | AGGAGGGAGAGAGAAAGAGAAGGGGGAGGUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
88 hsa-miR-6871-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061678 BTG2 BTG anti-proliferation factor 2 2 4
MIRT116181 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT150139 MIDN midnolin 2 2
MIRT197058 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT225108 GOLGA7 golgin A7 2 2
MIRT376288 CALM3 calmodulin 3 2 2
MIRT454810 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT464228 VEGFA vascular endothelial growth factor A 2 6
MIRT466961 STAT3 signal transducer and activator of transcription 3 2 2
MIRT468219 SGK1 serum/glucocorticoid regulated kinase 1 2 2
MIRT472460 NASP nuclear autoantigenic sperm protein 2 2
MIRT474203 LEPRE1 prolyl 3-hydroxylase 1 1 1
MIRT475836 HDGF heparin binding growth factor 2 4
MIRT478667 CTC1 CST telomere replication complex component 1 2 14
MIRT478707 CSRNP2 cysteine and serine rich nuclear protein 2 2 2
MIRT478982 COMMD2 COMM domain containing 2 2 2
MIRT479693 CCNT2 cyclin T2 2 6
MIRT488440 ULBP2 UL16 binding protein 2 2 2
MIRT492511 RAET1L retinoic acid early transcript 1L 2 2
MIRT492975 NCS1 neuronal calcium sensor 1 2 2
MIRT494158 COL4A1 collagen type IV alpha 1 chain 2 6
MIRT495934 SLC7A5P2 solute carrier family 7 member 5 pseudogene 2 2 2
MIRT496210 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT496356 PPY pancreatic polypeptide 2 2
MIRT496385 ZC3H6 zinc finger CCCH-type containing 6 2 2
MIRT496463 DCTN5 dynactin subunit 5 2 2
MIRT497642 GLDN gliomedin 2 2
MIRT498496 FRK fyn related Src family tyrosine kinase 2 2
MIRT501928 MCL1 MCL1, BCL2 family apoptosis regulator 2 8
MIRT513286 PDPK1 3-phosphoinositide dependent protein kinase 1 2 2
MIRT514767 RBM4B RNA binding motif protein 4B 2 2
MIRT514916 MDM2 MDM2 proto-oncogene 2 6
MIRT515669 LRRC27 leucine rich repeat containing 27 2 2
MIRT520367 UBE2G2 ubiquitin conjugating enzyme E2 G2 2 2
MIRT523960 DYNLT1 dynein light chain Tctex-type 1 2 4
MIRT526859 KIFC1 kinesin family member C1 2 2
MIRT527673 CASP8 caspase 8 2 2
MIRT527828 TMEM74B transmembrane protein 74B 2 2
MIRT529553 EI24 EI24, autophagy associated transmembrane protein 2 2
MIRT530547 SYNPO synaptopodin 2 2
MIRT531725 TARS threonyl-tRNA synthetase 2 2
MIRT533340 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT533620 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT537226 GAN gigaxonin 2 2
MIRT544430 ZNF460 zinc finger protein 460 2 4
MIRT546905 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT547102 PLAG1 PLAG1 zinc finger 2 2
MIRT547820 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT548236 FEM1B fem-1 homolog B 2 2
MIRT550034 WWTR1 WW domain containing transcription regulator 1 2 2
MIRT554337 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 4
MIRT565483 SPRTN SprT-like N-terminal domain 2 2
MIRT568200 CBX6 chromobox 6 2 2
MIRT569754 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT571369 ZNF45 zinc finger protein 45 2 2
MIRT609886 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT640543 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT640885 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT643494 LRCH3 leucine rich repeats and calponin homology domain containing 3 2 2
MIRT643627 YY2 YY2 transcription factor 2 2
MIRT644384 ZNF286A zinc finger protein 286A 2 2
MIRT646126 SLC26A9 solute carrier family 26 member 9 2 2
MIRT655939 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT656057 MYLK4 myosin light chain kinase family member 4 2 2
MIRT658767 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT661583 EPHX2 epoxide hydrolase 2 2 2
MIRT664285 RNMTL1 mitochondrial rRNA methyltransferase 3 2 2
MIRT689391 ZNF850 zinc finger protein 850 2 2
MIRT694530 TRIM72 tripartite motif containing 72 2 2
MIRT694626 ZFPM1 zinc finger protein, FOG family member 1 2 2
MIRT695133 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695150 PRY PTPN13-like, Y-linked 2 2
MIRT697468 ZC3H4 zinc finger CCCH-type containing 4 2 2
MIRT701919 MLXIP MLX interacting protein 2 2
MIRT704548 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT704791 CDK6 cyclin dependent kinase 6 2 2
MIRT705696 ANKRD13A ankyrin repeat domain 13A 2 2
MIRT707992 OTUD4 OTU deubiquitinase 4 2 2
MIRT708739 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT713401 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT713846 FAM3D family with sequence similarity 3 member D 2 2
MIRT716998 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT718511 DIRAS1 DIRAS family GTPase 1 2 2
MIRT718698 BTBD9 BTB domain containing 9 2 2
MIRT719578 TYRO3 TYRO3 protein tyrosine kinase 2 2
MIRT720892 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2 2
MIRT722633 C8A complement C8 alpha chain 2 2
MIRT723333 DGAT1 diacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6871-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6871-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6871-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6871-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)

Error report submission