pre-miRNA Information
pre-miRNA hsa-mir-4708   
Genomic Coordinates chr14: 65335117 - 65335183
Description Homo sapiens miR-4708 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4708-5p
Sequence 9| AGAGAUGCCGCCUUGCUCCUU |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1017378847 9 dbSNP
rs750825813 10 dbSNP
rs1297395738 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol C2orf15   
Synonyms -
Description chromosome 2 open reading frame 15
Transcript NM_144706   
Expression
Putative miRNA Targets on C2orf15
3'UTR of C2orf15
(miRNA target sites are highlighted)
>C2orf15|NM_144706|3'UTR
   1 AGCAATTTGTACGTATTACCAAAGAAACCAAAAACTGCCTTTGACTAAGGGGGGTGTTGAAAGAGAACTTAACCTTATTA
  81 GGAAACCCTGACAAAATGATGGAAGACTATTGCCTTATTTTGCACTATTTGTGAATCATCTTACACTGCATTTTTTTATG
 161 ATGCTTATTCAAAAGGCAGTTGCTTTAGGGTGAAAAAGCCTTCCAAGATTCAAAGCAGATTTCTCTGGTATTATATTATA
 241 TCCTTCTTAAAAACCAGAGTTTTTAAGTAACAGTATTTGAATGGCATCAAAACATTTTCATTTTAATGTATTTCTTTAAC
 321 AAGTGGTTAAAAAAAGTGTCCAAGCAGCCGGGCGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGG
 401 GTCAATCACCTGAGGTCAGGAGTTCGCAACCAGCCTGGCCAATATGGTGAGACCCCATCTCTACTAAAAATGCAAAAAGT
 481 TAGCCAGGCATGGTGGTGGGCACCTGTGATCCCAGCTACCTGGGAGGCTGAGGAAGGAGAATCGCTTGAACCCTGGAGGC
 561 GGAGGCTGCACTGAGCTGAGGTCATGCCATTGTACTCCAGCCTGGGCAACAAGAGCAAAACTCCGTCTCAAAAAAAAAAA
 641 AAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uuccUCGUUCCGCCGUAGAGa 5'
              :|::|| |  |||||| 
Target 5' atatGGTGAGACCCCATCTCt 3'
442 - 462 125.00 -10.70
2
miRNA  3' uucCUCGUUCCGCCGUAGAGa 5'
             ||||||  |  |:|||| 
Target 5' caaGAGCAAAACTCCGTCTCa 3'
610 - 630 118.00 -13.00
3
miRNA  3' uuccucguuccGCCGUAGAGa 5'
                     | ||||:|: 
Target 5' atcatcttacaCTGCATTTTt 3'
135 - 155 110.00 -5.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN14017258 14 COSMIC
COSN30122587 54 COSMIC
COSN5270497 55 COSMIC
COSN30129399 66 COSMIC
COSN31552825 123 COSMIC
COSN5270498 123 COSMIC
COSN9394469 353 COSMIC
COSN22787739 467 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs751665325 1 dbSNP
rs1488812718 5 dbSNP
rs756640722 6 dbSNP
rs144085307 8 dbSNP
rs185415798 9 dbSNP
rs1289183743 12 dbSNP
rs111826595 13 dbSNP
rs376071599 14 dbSNP
rs1282496043 15 dbSNP
rs1391302908 25 dbSNP
rs879069731 29 dbSNP
rs1305548089 31 dbSNP
rs779926644 36 dbSNP
rs1234859315 38 dbSNP
rs1280529582 41 dbSNP
rs368152150 42 dbSNP
rs1208412705 46 dbSNP
rs768100089 48 dbSNP
rs763094198 49 dbSNP
rs764730615 49 dbSNP
rs774062161 49 dbSNP
rs1047188023 50 dbSNP
rs374028854 51 dbSNP
rs1173854357 52 dbSNP
rs886207080 55 dbSNP
rs112564961 57 dbSNP
rs868706269 61 dbSNP
rs1176326017 64 dbSNP
rs1016001642 66 dbSNP
rs1194579823 70 dbSNP
rs145478469 75 dbSNP
rs1019521672 87 dbSNP
rs894836972 96 dbSNP
rs572375617 97 dbSNP
rs1257041155 101 dbSNP
rs899672668 102 dbSNP
rs1321490798 108 dbSNP
rs997085437 108 dbSNP
rs1032400688 109 dbSNP
rs541068536 110 dbSNP
rs1262506051 115 dbSNP
rs10201856 123 dbSNP
rs528283161 129 dbSNP
rs1385490942 132 dbSNP
rs1268225889 140 dbSNP
rs971586412 151 dbSNP
rs981586725 154 dbSNP
rs1384052203 158 dbSNP
rs1032282244 159 dbSNP
rs1020956112 180 dbSNP
rs1322499148 186 dbSNP
rs1403750866 191 dbSNP
rs970752490 217 dbSNP
rs956221551 219 dbSNP
rs1466621074 227 dbSNP
rs990675884 229 dbSNP
rs914661580 231 dbSNP
rs1475256880 232 dbSNP
rs190897202 233 dbSNP
rs1383608901 235 dbSNP
rs1460068515 242 dbSNP
rs1242591272 247 dbSNP
rs926866651 255 dbSNP
rs974707659 256 dbSNP
rs772557123 258 dbSNP
rs923198051 274 dbSNP
rs1213832769 278 dbSNP
rs1356778578 283 dbSNP
rs1285630898 287 dbSNP
rs1277981040 293 dbSNP
rs1350455077 294 dbSNP
rs1309392217 308 dbSNP
rs1206047731 310 dbSNP
rs1448262533 311 dbSNP
rs933201870 327 dbSNP
rs1327423860 329 dbSNP
rs1047621120 336 dbSNP
rs77235418 337 dbSNP
rs1270601984 344 dbSNP
rs938159459 350 dbSNP
rs182852568 351 dbSNP
rs563849747 352 dbSNP
rs148829737 354 dbSNP
rs931038465 355 dbSNP
rs1046838534 358 dbSNP
rs886765873 362 dbSNP
rs1231167727 364 dbSNP
rs1037894786 365 dbSNP
rs894856723 370 dbSNP
rs1425031508 371 dbSNP
rs1011873133 377 dbSNP
rs571446360 378 dbSNP
rs1219925924 385 dbSNP
rs538583283 393 dbSNP
rs943743781 394 dbSNP
rs1040899987 399 dbSNP
rs899766561 400 dbSNP
rs1470400527 402 dbSNP
rs1442088413 403 dbSNP
rs549670419 406 dbSNP
rs1427114847 411 dbSNP
rs1469285707 414 dbSNP
rs879647216 426 dbSNP
rs566248561 427 dbSNP
rs1405852385 434 dbSNP
rs1176639663 435 dbSNP
rs1270876016 442 dbSNP
rs956447239 442 dbSNP
rs1010061036 446 dbSNP
rs1197028178 453 dbSNP
rs1011706683 455 dbSNP
rs1021090142 466 dbSNP
rs35506231 474 dbSNP
rs1403061991 481 dbSNP
rs528050280 483 dbSNP
rs970677424 485 dbSNP
rs982118906 493 dbSNP
rs1219269720 494 dbSNP
rs188947556 499 dbSNP
rs1033904051 527 dbSNP
rs571268996 531 dbSNP
rs1290527185 533 dbSNP
rs2931530 537 dbSNP
rs1284114285 538 dbSNP
rs1345236105 541 dbSNP
rs536729859 544 dbSNP
rs1433178488 554 dbSNP
rs1343611210 561 dbSNP
rs1158481325 562 dbSNP
rs974760076 569 dbSNP
rs11890338 572 dbSNP
rs973703353 579 dbSNP
rs568535024 589 dbSNP
rs954679958 591 dbSNP
rs1484708957 597 dbSNP
rs1210225890 604 dbSNP
rs1462262544 608 dbSNP
rs1265581054 611 dbSNP
rs1222194648 617 dbSNP
rs1323384304 621 dbSNP
rs1279265030 623 dbSNP
rs1360150704 625 dbSNP
rs929522843 625 dbSNP
rs143578429 626 dbSNP
rs1448934663 626 dbSNP
rs1408351297 629 dbSNP
rs1469251834 629 dbSNP
rs1491183950 629 dbSNP
rs1182085566 630 dbSNP
rs1207133123 630 dbSNP
rs1240744891 630 dbSNP
rs1252343512 630 dbSNP
rs1280239020 630 dbSNP
rs1295174247 630 dbSNP
rs1306122020 630 dbSNP
rs1424203695 630 dbSNP
rs1491102407 630 dbSNP
rs55966864 630 dbSNP
rs746215848 630 dbSNP
rs747303058 630 dbSNP
rs758554997 630 dbSNP
rs869088484 630 dbSNP
rs865801267 638 dbSNP
rs1385201756 639 dbSNP
rs1249394293 655 dbSNP
rs1437978483 661 dbSNP
rs1400962628 664 dbSNP
rs908300688 673 dbSNP
rs1183889498 674 dbSNP
rs553184020 675 dbSNP
rs943671800 684 dbSNP
rs1353681538 685 dbSNP
rs1165151469 698 dbSNP
rs1446112475 701 dbSNP
rs907782808 710 dbSNP
rs1182456539 731 dbSNP
rs1040707037 739 dbSNP
rs1439757843 740 dbSNP
rs1179430623 741 dbSNP
rs1251128917 743 dbSNP
rs1479891861 743 dbSNP
rs1223636231 746 dbSNP
rs1479974493 759 dbSNP
rs1289794834 762 dbSNP
rs11123765 768 dbSNP
rs1037504518 772 dbSNP
rs1309114592 791 dbSNP
rs1389624739 795 dbSNP
rs1372472066 796 dbSNP
rs545326336 797 dbSNP
rs1467667663 798 dbSNP
rs557862723 809 dbSNP
rs147643448 813 dbSNP
rs1162530300 818 dbSNP
rs1046120426 819 dbSNP
rs906243628 826 dbSNP
rs1156254648 830 dbSNP
rs1410742038 831 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uuCCUCGUUCCGCCGUAGAGa 5'
            ||| ::|| |  |||||| 
Target 5' -aGGA-UGAGACUCCAUCUCa 3'
1 - 19
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000512183.2 | 3UTR | AGGAUGAGACUCCAUCUCAGGGGAAAAAAAAAAAUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
94 hsa-miR-4708-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT095681 RBM27 RNA binding motif protein 27 2 4
MIRT104033 USP42 ubiquitin specific peptidase 42 2 6
MIRT114773 CMPK1 cytidine/uridine monophosphate kinase 1 2 2
MIRT246923 CCND1 cyclin D1 2 2
MIRT392569 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT443949 LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 2 2
MIRT446695 PAPPA pappalysin 1 2 2
MIRT447383 VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2 2
MIRT449321 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT449717 C1orf61 chromosome 1 open reading frame 61 2 2
MIRT449738 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2 2
MIRT450531 PGLS 6-phosphogluconolactonase 2 2
MIRT455650 YARS tyrosyl-tRNA synthetase 2 2
MIRT458036 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT463468 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT466677 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 4
MIRT467789 SLC2A14 solute carrier family 2 member 14 2 2
MIRT468167 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT468652 SECISBP2L SECIS binding protein 2 like 2 6
MIRT469380 RER1 retention in endoplasmic reticulum sorting receptor 1 2 2
MIRT470346 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT472418 NCKAP1 NCK associated protein 1 2 2
MIRT474612 KLF3 Kruppel like factor 3 2 2
MIRT478703 CSRNP2 cysteine and serine rich nuclear protein 2 2 2
MIRT481008 BBC3 BCL2 binding component 3 2 4
MIRT483098 TFPI tissue factor pathway inhibitor 2 2
MIRT485113 SHISA6 shisa family member 6 2 2
MIRT497533 ZNF607 zinc finger protein 607 2 2
MIRT500644 TUBB2A tubulin beta 2A class IIa 2 6
MIRT500890 STRN striatin 2 4
MIRT501900 MED13 mediator complex subunit 13 2 2
MIRT506646 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT512675 ENO4 enolase family member 4 2 2
MIRT516977 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT528754 RPS27 ribosomal protein S27 2 6
MIRT539670 ZBTB44 zinc finger and BTB domain containing 44 2 2
MIRT544129 PPIL1 peptidylprolyl isomerase like 1 2 2
MIRT546382 STOX2 storkhead box 2 2 4
MIRT562143 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568713 TMEM30B transmembrane protein 30B 2 2
MIRT571029 CENPP centromere protein P 2 2
MIRT572781 ZNF277 zinc finger protein 277 2 2
MIRT573162 SLC30A9 solute carrier family 30 member 9 2 2
MIRT609126 NUDT3 nudix hydrolase 3 2 2
MIRT609284 OAS3 2'-5'-oligoadenylate synthetase 3 2 2
MIRT613430 GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2 2
MIRT613770 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT616645 LRAT lecithin retinol acyltransferase 2 4
MIRT630892 SLC25A33 solute carrier family 25 member 33 2 2
MIRT636526 FAXC failed axon connections homolog 2 4
MIRT641394 NUBPL nucleotide binding protein like 2 2
MIRT641412 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT642528 CERS4 ceramide synthase 4 2 2
MIRT643186 HYPK huntingtin interacting protein K 2 2
MIRT647800 FRMD8 FERM domain containing 8 2 2
MIRT652150 TRIM71 tripartite motif containing 71 2 2
MIRT652602 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT661606 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT666339 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT670414 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671122 ZNF573 zinc finger protein 573 2 2
MIRT671155 ANKRD9 ankyrin repeat domain 9 2 2
MIRT671338 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT671869 ZNF429 zinc finger protein 429 2 2
MIRT671974 IKZF3 IKAROS family zinc finger 3 2 2
MIRT672064 KIAA0930 KIAA0930 2 2
MIRT672654 SLC25A16 solute carrier family 25 member 16 2 4
MIRT672673 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT672771 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672929 LRRC2 leucine rich repeat containing 2 2 2
MIRT673159 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673272 RUNDC1 RUN domain containing 1 2 2
MIRT673332 THAP1 THAP domain containing 1 2 2
MIRT673351 SLC35F6 solute carrier family 35 member F6 2 2
MIRT673667 ZNF440 zinc finger protein 440 2 2
MIRT673904 DCTN6 dynactin subunit 6 2 2
MIRT674096 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT674401 MYCBP MYC binding protein 2 2
MIRT674525 PRR23A proline rich 23A 2 2
MIRT674793 NPR1 natriuretic peptide receptor 1 2 2
MIRT674833 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 2
MIRT675066 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT675080 CCR6 C-C motif chemokine receptor 6 2 2
MIRT675126 FSD2 fibronectin type III and SPRY domain containing 2 2 2
MIRT679401 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT689229 RPS19 ribosomal protein S19 2 2
MIRT694008 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT699671 SFT2D2 SFT2 domain containing 2 2 2
MIRT706213 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706548 GJD2 gap junction protein delta 2 2 2
MIRT707418 RRP7A ribosomal RNA processing 7 homolog A 2 2
MIRT710648 GLUL glutamate-ammonia ligase 2 2
MIRT719393 NPCA1 Nasopharyngeal carcinoma 1 2 2
MIRT720166 PNPO pyridoxamine 5'-phosphate oxidase 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4708-5p Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tripterygium wilfordii Hook F sensitive tissue
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-4708-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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