pre-miRNA Information
pre-miRNA hsa-mir-1245a   
Genomic Coordinates chr2: 188978092 - 188978161
Description Homo sapiens miR-1245a stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1245a
Sequence 45| AAGUGAUCUAAAGGCCUACAU |65
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31562560 15 COSMIC
COSN26581044 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs906938680 2 dbSNP
rs1159117523 3 dbSNP
rs780486044 6 dbSNP
rs771479866 17 dbSNP
rs1002976932 18 dbSNP
rs1428029219 19 dbSNP
Putative Targets

Gene Information
Gene Symbol FUT2   
Synonyms B12QTL1, SE, SEC2, Se2, sej
Description fucosyltransferase 2
Transcript NM_000511   
Other Transcripts NM_001097638   
Expression
Putative miRNA Targets on FUT2
3'UTR of FUT2
(miRNA target sites are highlighted)
>FUT2|NM_000511|3'UTR
   1 TGCTGGCCCATTCTTTGAGACCTTTTCTCCTTCTCTGCCTCCCTCAAGATGAGTGCCCGGGCATGAGAAGCACATGGTTC
  81 CATGAGCAGGACCCATCTCTCTTCTGTGAAGATGCGTTGGGCTGCAAGTAACAGAAATCTCAGTGAACAGTGGCCTGGCG
 161 TGGTGGCTCATGCCTGTAATGCTCGCACTTTGTGAGGCCAGGGTGGGTGGATCACTTGAGGTCAGGAGTTCAAGACTAGC
 241 CTGGCCAACATGGTGAAACCCCATCTCGACTAAAAATACAAAAATTAGCCAGGCGTGGTGGTGCACACCTGTAATCCCAG
 321 CTACTCGGGAGGCTGAGGCAAGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATGGTGCCGCTGCAC
 401 TCCAGTCTGGGTGACACAGCAAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAGAAAAGAAAAAGAAATGAATGGGTTCA
 481 AAGACCATAATCATGCATATCACATAAGACCAGAAGTGGCCCAGGTCCAGGGTCAGTTAATTTAGCGGCTCCACAAAGTC
 561 ATCAGTCACCTGAGCTCCATCCATCTTCACATGCTGTGCTACCATTTCTTAGCTGTATCATCCCATGGTCCCAAAAGGGC
 641 TGCTACACATCCAGCCATCACATGCAGATAATTCCTTTCAAAAACAGCAGAAAGAGGCTCGTTCTTGTCTTGGTCCCTTT
 721 TGAAGAATGAATGAAACCTTCCTAAGCCTTCCAGCAATTTCCCCCCAACTCCGATGGGTAGGAATTGTCACATACCCATG
 801 TGACCCGATAGGAGGCAAAAGAAATGAGACTTCTGGGATTAGTTTAGCCTCAGATTCTGCAGCTGAGAAGTTGATCAGCC
 881 ACCTCTGAAGGACATGCAGCTTGCAGAAAATTAGGGTGGTGTTACCAAGGTGAAAAGGGGAAATGGCTTTAGAGTAGACA
 961 ACAGAGATGCCCTGAGGGGTTGTGTAGGTTGTTCACTGCAGGAAGTCCCCTGGTTAAGAAGGCAAGTGGGGTTTAAACAG
1041 ACCCACAGTCTACTCATCAAACCAGGTGTCCTTGGCATTGTGTCCACCCAGAGAGCTCACTGTTTTCTTTTCTTTTTCTT
1121 TTCTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTGCATCCCCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTG
1201 CAGCCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTAGGATTACAGGTGCGTGCCACCACG
1281 CCCAGCTAATTTTTATATGTTTAGTGGAAATGGAGTTTCACCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCATGA
1361 TCCGCCTTCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTTAGCCACTGCGCCCGGCCCTAGAGCTCACTGTTTTCTA
1441 GTTAGTCCATCTGGAAGTGGAGCCTTTTTCCAGTTTGCACAAATGTGCCATATTGGCTTGTAGCTGGCATGCATCCAAGT
1521 CCATAGGTCCTGCCTCTTCAATCCTGGCTTTCTAGGGCCTGGGATGATCATTGCTAGAACTGAGAGACCAGCCTGGCTCA
1601 GTGAACTTCAGGGCGTTCCGTTCATTCTTTCAGTAAATGTTTGCAGCACATGTGTTACATGTCAGGCAGTGAAACCCCCC
1681 ACAGCAGCCTTCCCTCTCAGAGGATACATTTGTAACCATTACACAGTCATCAAAGGAATAATTTTTTTTAATCACCAGTG
1761 TGCATACAGTCATGGAGTTGGGTATTCCCAGCTACCAGGGAGGCTGAGGTGGGAGGATTGCTTGATGCCAGGAGTTAGGG
1841 AATATAGTGCACCGTGATTGGACTTGCGAATAGCCACTGCACTGCGGCCTGGACGACGTAGTGATACCCTGACTCTTATA
1921 AATAAATAAATGAATAAACACAATTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uaCAUCCGGAAAUCUAGUGAa 5'
            ||:||    |:||||||| 
Target 5' ggGTGGG----TGGATCACTt 3'
201 - 217 153.00 -16.30
2
miRNA  3' uacAU-CCGGAAAU--CUAGUGAa 5'
             || |||||  :  |||||:| 
Target 5' ttcTAGGGCCTGGGATGATCATTg 3'
1550 - 1573 136.00 -15.20
3
miRNA  3' uacaUCCGGAAAUCUAGUGAa 5'
              :| |||  || ||||| 
Target 5' gcccGGCCCTAGAGCTCACTg 3'
1413 - 1433 125.00 -11.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM8806640 1 COSMIC
COSN31613464 5 COSMIC
COSN30606575 33 COSMIC
COSN30521167 46 COSMIC
COSN30139975 116 COSMIC
COSN31512755 117 COSMIC
COSN30543629 150 COSMIC
COSN31557210 160 COSMIC
COSN31555517 174 COSMIC
COSN31595240 177 COSMIC
COSN30125129 186 COSMIC
COSN28814669 215 COSMIC
COSN30143669 295 COSMIC
COSN30142659 345 COSMIC
COSN28766835 407 COSMIC
COSN23012664 450 COSMIC
COSN17463949 455 COSMIC
COSN30142050 471 COSMIC
COSN31549827 492 COSMIC
COSN31538970 501 COSMIC
COSN15624159 533 COSMIC
COSN28765145 548 COSMIC
COSN30120166 688 COSMIC
COSN6552798 826 COSMIC
COSN32065247 1059 COSMIC
COSN30144231 1072 COSMIC
COSN30144029 1082 COSMIC
COSN18841130 1108 COSMIC
COSN28787994 1124 COSMIC
COSN30126408 1128 COSMIC
COSN30136896 1129 COSMIC
COSN7447590 1300 COSMIC
COSN30537813 1375 COSMIC
COSN30510330 1377 COSMIC
COSN9851453 1444 COSMIC
COSN31529999 1519 COSMIC
COSN28796391 1621 COSMIC
COSN28771933 1734 COSMIC
COSN31517819 1742 COSMIC
COSN31961571 1750 COSMIC
COSN26505513 1786 COSMIC
COSN31562527 1859 COSMIC
COSN31523367 1868 COSMIC
COSN30115882 1887 COSMIC
COSN23363059 1898 COSMIC
rs603985 13 GWAS
rs2432132 1124 GWAS
rs504963 1621 GWAS
rs632111 1734 GWAS
rs503279 1766 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs771982255 1 dbSNP
rs780209339 2 dbSNP
rs1159564691 3 dbSNP
rs368513794 7 dbSNP
rs1364065883 10 dbSNP
rs74183384 10 dbSNP
rs485073 11 dbSNP
rs112950322 12 dbSNP
rs603985 13 dbSNP
rs1397254339 14 dbSNP
rs762901305 22 dbSNP
rs112058615 23 dbSNP
rs771198083 23 dbSNP
rs1293527057 30 dbSNP
rs1461027583 31 dbSNP
rs1388652185 32 dbSNP
rs1393268753 34 dbSNP
rs1329759439 40 dbSNP
rs376574452 42 dbSNP
rs1242850781 43 dbSNP
rs771233484 51 dbSNP
rs1026021552 59 dbSNP
rs972259484 60 dbSNP
rs952379679 62 dbSNP
rs1248700191 72 dbSNP
rs547678363 74 dbSNP
rs1266398234 91 dbSNP
rs1450099767 93 dbSNP
rs1377990296 95 dbSNP
rs769653435 101 dbSNP
rs985017899 112 dbSNP
rs910786676 116 dbSNP
rs144000993 117 dbSNP
rs970233814 124 dbSNP
rs1040389654 128 dbSNP
rs1444023324 133 dbSNP
rs901963703 133 dbSNP
rs981485856 140 dbSNP
rs1188467901 151 dbSNP
rs1458293755 152 dbSNP
rs185388503 160 dbSNP
rs551728977 161 dbSNP
rs1223964881 170 dbSNP
rs1383664899 174 dbSNP
rs1490983578 177 dbSNP
rs928713358 185 dbSNP
rs892272863 186 dbSNP
rs934796339 187 dbSNP
rs28362840 188 dbSNP
rs1295886393 192 dbSNP
rs1368848549 193 dbSNP
rs281376 194 dbSNP
rs1359664324 195 dbSNP
rs905111490 197 dbSNP
rs555879115 201 dbSNP
rs1405552510 204 dbSNP
rs1001865349 210 dbSNP
rs1296416455 211 dbSNP
rs568158277 214 dbSNP
rs960494158 224 dbSNP
rs993624692 226 dbSNP
rs1172874265 238 dbSNP
rs1426950772 241 dbSNP
rs1419337503 251 dbSNP
rs1402333135 252 dbSNP
rs1200612415 265 dbSNP
rs535588117 269 dbSNP
rs770912866 294 dbSNP
rs774644840 295 dbSNP
rs189504139 296 dbSNP
rs759849130 301 dbSNP
rs1195686000 303 dbSNP
rs1263305035 304 dbSNP
rs1427371608 307 dbSNP
rs1167668080 308 dbSNP
rs571689 310 dbSNP
rs993287588 312 dbSNP
rs1026389860 317 dbSNP
rs1225645874 327 dbSNP
rs1253634254 328 dbSNP
rs1319180589 340 dbSNP
rs1281346949 342 dbSNP
rs1203171542 349 dbSNP
rs1374222737 350 dbSNP
rs976090584 354 dbSNP
rs923237164 362 dbSNP
rs1221857457 363 dbSNP
rs374477120 366 dbSNP
rs1006860831 367 dbSNP
rs1427599129 371 dbSNP
rs1199388525 384 dbSNP
rs1053638192 394 dbSNP
rs28746181 395 dbSNP
rs970181381 399 dbSNP
rs558170404 405 dbSNP
rs570794 407 dbSNP
rs1203875153 416 dbSNP
rs181245327 417 dbSNP
rs1175534345 421 dbSNP
rs1403281243 428 dbSNP
rs1449519289 429 dbSNP
rs1303095736 430 dbSNP
rs1336286761 431 dbSNP
rs1308982795 433 dbSNP
rs1389772645 433 dbSNP
rs1157507271 434 dbSNP
rs1172356736 434 dbSNP
rs1237007887 434 dbSNP
rs1271234393 434 dbSNP
rs1292868617 434 dbSNP
rs1366072114 434 dbSNP
rs140411756 434 dbSNP
rs1437322733 434 dbSNP
rs1454572256 434 dbSNP
rs753260230 434 dbSNP
rs764829292 434 dbSNP
rs765220953 434 dbSNP
rs796673354 434 dbSNP
rs1360796489 436 dbSNP
rs1380929618 439 dbSNP
rs1280471227 441 dbSNP
rs1341450077 442 dbSNP
rs372342255 443 dbSNP
rs532039628 443 dbSNP
rs1261765358 444 dbSNP
rs1262458424 444 dbSNP
rs1468816959 444 dbSNP
rs1325798040 445 dbSNP
rs1236757952 447 dbSNP
rs1210870888 448 dbSNP
rs1353143481 448 dbSNP
rs938332345 449 dbSNP
rs1333688398 450 dbSNP
rs1380863255 450 dbSNP
rs905122624 453 dbSNP
rs76209092 454 dbSNP
rs112479907 455 dbSNP
rs879069672 460 dbSNP
rs1265065534 464 dbSNP
rs1379224162 464 dbSNP
rs1477991946 466 dbSNP
rs1198628236 469 dbSNP
rs1427063212 470 dbSNP
rs569970 474 dbSNP
rs1186356262 475 dbSNP
rs562166036 484 dbSNP
rs1447407947 488 dbSNP
rs529379640 498 dbSNP
rs1344293845 501 dbSNP
rs1035899499 514 dbSNP
rs956299854 517 dbSNP
rs754425812 528 dbSNP
rs28746182 529 dbSNP
rs1487920708 544 dbSNP
rs757614652 547 dbSNP
rs2251034 548 dbSNP
rs947425762 559 dbSNP
rs979278359 562 dbSNP
rs1361602507 566 dbSNP
rs533653828 573 dbSNP
rs551691877 593 dbSNP
rs1228399083 597 dbSNP
rs1328619454 618 dbSNP
rs951765827 619 dbSNP
rs943330060 621 dbSNP
rs570103128 625 dbSNP
rs1040165748 627 dbSNP
rs1006432473 634 dbSNP
rs1370334843 640 dbSNP
rs1017745447 642 dbSNP
rs1305436649 649 dbSNP
rs760605522 657 dbSNP
rs1426035637 659 dbSNP
rs556564192 675 dbSNP
rs964974467 677 dbSNP
rs976719105 680 dbSNP
rs1374651726 685 dbSNP
rs929021701 694 dbSNP
rs1477340551 698 dbSNP
rs1269548701 700 dbSNP
rs531251556 701 dbSNP
rs988820216 702 dbSNP
rs914681639 708 dbSNP
rs372340430 731 dbSNP
rs1219090590 738 dbSNP
rs549367381 743 dbSNP
rs1043547326 747 dbSNP
rs568104943 753 dbSNP
rs78667713 759 dbSNP
rs79565041 761 dbSNP
rs1005899851 765 dbSNP
rs1346494959 770 dbSNP
rs1022672266 773 dbSNP
rs1403618291 774 dbSNP
rs906111534 778 dbSNP
rs1266743929 783 dbSNP
rs147051249 788 dbSNP
rs28362841 796 dbSNP
rs896387887 797 dbSNP
rs928995586 799 dbSNP
rs28362842 804 dbSNP
rs567037 808 dbSNP
rs1429706458 810 dbSNP
rs1416745534 818 dbSNP
rs184968768 822 dbSNP
rs1021711636 825 dbSNP
rs866549016 828 dbSNP
rs997683645 832 dbSNP
rs1182634183 837 dbSNP
rs1424780646 839 dbSNP
rs576409524 840 dbSNP
rs1031035845 844 dbSNP
rs1256430241 848 dbSNP
rs1380500921 850 dbSNP
rs1324784421 852 dbSNP
rs1424483808 868 dbSNP
rs1218053047 870 dbSNP
rs1301666732 873 dbSNP
rs969087674 880 dbSNP
rs537402724 882 dbSNP
rs536150948 896 dbSNP
rs1442329920 911 dbSNP
rs1336975067 916 dbSNP
rs574052097 919 dbSNP
rs758777432 924 dbSNP
rs541195881 929 dbSNP
rs964589174 931 dbSNP
rs975986922 932 dbSNP
rs1412484456 945 dbSNP
rs1358965172 948 dbSNP
rs1245044559 953 dbSNP
rs879045579 954 dbSNP
rs188167052 966 dbSNP
rs577856671 970 dbSNP
rs1236413258 985 dbSNP
rs929158066 988 dbSNP
rs1178326484 997 dbSNP
rs1047902951 999 dbSNP
rs908955426 1002 dbSNP
rs28362843 1006 dbSNP
rs929198875 1008 dbSNP
rs1208481136 1014 dbSNP
rs1442157322 1016 dbSNP
rs1232197544 1018 dbSNP
rs563591286 1023 dbSNP
rs1044065778 1024 dbSNP
rs1225944398 1027 dbSNP
rs1355301497 1028 dbSNP
rs1047856260 1041 dbSNP
rs1238705145 1043 dbSNP
rs2638279 1046 dbSNP
rs887420691 1047 dbSNP
rs941659735 1049 dbSNP
rs531117196 1060 dbSNP
rs1443629619 1069 dbSNP
rs1358325125 1074 dbSNP
rs1318946755 1078 dbSNP
rs1392925345 1081 dbSNP
rs900245781 1084 dbSNP
rs1003096863 1086 dbSNP
rs1030461138 1090 dbSNP
rs772423883 1099 dbSNP
rs1472698034 1100 dbSNP
rs28362844 1100 dbSNP
rs759419897 1100 dbSNP
rs781289726 1100 dbSNP
rs138075927 1101 dbSNP
rs147298829 1102 dbSNP
rs1356466532 1103 dbSNP
rs148901607 1103 dbSNP
rs892052293 1103 dbSNP
rs1010457621 1104 dbSNP
rs751299605 1107 dbSNP
rs1353234846 1108 dbSNP
rs878926021 1108 dbSNP
rs1449148816 1111 dbSNP
rs767116404 1112 dbSNP
rs879251280 1113 dbSNP
rs1332107056 1114 dbSNP
rs771051879 1117 dbSNP
rs1382387289 1118 dbSNP
rs146519458 1119 dbSNP
rs750075953 1119 dbSNP
rs1450724398 1120 dbSNP
rs1358566647 1121 dbSNP
rs1286130371 1122 dbSNP
rs1358247092 1123 dbSNP
rs1163009438 1124 dbSNP
rs1297453811 1124 dbSNP
rs1423457086 1124 dbSNP
rs2432132 1124 dbSNP
rs764196118 1124 dbSNP
rs113153848 1125 dbSNP
rs1188670861 1127 dbSNP
rs1263137544 1128 dbSNP
rs1477017400 1128 dbSNP
rs868855781 1129 dbSNP
rs1272268366 1130 dbSNP
rs1266681027 1132 dbSNP
rs1219022135 1134 dbSNP
rs1315976178 1135 dbSNP
rs112820994 1136 dbSNP
rs1238255838 1139 dbSNP
rs1220266059 1141 dbSNP
rs1031492296 1142 dbSNP
rs1184990920 1143 dbSNP
rs980058964 1144 dbSNP
rs1246979914 1145 dbSNP
rs1473352405 1147 dbSNP
rs1034428790 1148 dbSNP
rs955425753 1149 dbSNP
rs960146396 1158 dbSNP
rs992402172 1159 dbSNP
rs1418059569 1160 dbSNP
rs1464425856 1172 dbSNP
rs1467636699 1174 dbSNP
rs112140559 1177 dbSNP
rs528958901 1180 dbSNP
rs547219480 1181 dbSNP
rs1265808977 1183 dbSNP
rs1188968152 1206 dbSNP
rs1057390621 1209 dbSNP
rs891918021 1210 dbSNP
rs929234174 1222 dbSNP
rs1010410141 1226 dbSNP
rs28362845 1227 dbSNP
rs1290761238 1229 dbSNP
rs1223825171 1231 dbSNP
rs780715769 1247 dbSNP
rs539599894 1248 dbSNP
rs187173109 1249 dbSNP
rs507855 1257 dbSNP
rs545464708 1270 dbSNP
rs1220407812 1280 dbSNP
rs537365058 1281 dbSNP
rs1376457670 1285 dbSNP
rs923221665 1295 dbSNP
rs1322254854 1297 dbSNP
rs507766 1299 dbSNP
rs1052377668 1300 dbSNP
rs1280357323 1312 dbSNP
rs192420604 1314 dbSNP
rs507711 1320 dbSNP
rs752225090 1321 dbSNP
rs1237127208 1328 dbSNP
rs909061577 1329 dbSNP
rs1261480467 1330 dbSNP
rs1478971823 1335 dbSNP
rs1254217567 1339 dbSNP
rs372565082 1345 dbSNP
rs1195077812 1352 dbSNP
rs774307589 1356 dbSNP
rs763014846 1358 dbSNP
rs1232407798 1362 dbSNP
rs553236359 1364 dbSNP
rs577717320 1365 dbSNP
rs1237970194 1367 dbSNP
rs759790492 1373 dbSNP
rs1034271849 1374 dbSNP
rs1403264492 1382 dbSNP
rs938328311 1383 dbSNP
rs506897 1385 dbSNP
rs1316419705 1395 dbSNP
rs1302825309 1400 dbSNP
rs12971304 1401 dbSNP
rs142974478 1413 dbSNP
rs1401573995 1414 dbSNP
rs1159944630 1416 dbSNP
rs751457688 1417 dbSNP
rs1026133422 1418 dbSNP
rs950611217 1420 dbSNP
rs28746183 1427 dbSNP
rs372103105 1427 dbSNP
rs1253797832 1430 dbSNP
rs1199866315 1431 dbSNP
rs1486154722 1434 dbSNP
rs1288005965 1438 dbSNP
rs1010942899 1452 dbSNP
rs183368302 1454 dbSNP
rs909168641 1464 dbSNP
rs1230509902 1472 dbSNP
rs12985342 1474 dbSNP
rs1316048133 1474 dbSNP
rs1043220192 1491 dbSNP
rs1345015684 1492 dbSNP
rs28362846 1497 dbSNP
rs1283375554 1499 dbSNP
rs1363027132 1501 dbSNP
rs933082843 1501 dbSNP
rs1296842322 1503 dbSNP
rs1417365044 1506 dbSNP
rs867583895 1507 dbSNP
rs1359325445 1515 dbSNP
rs1163535702 1524 dbSNP
rs1006907512 1534 dbSNP
rs751638878 1535 dbSNP
rs1051544740 1540 dbSNP
rs1186592474 1541 dbSNP
rs561718061 1542 dbSNP
rs1265292008 1545 dbSNP
rs1191382710 1546 dbSNP
rs1488032870 1557 dbSNP
rs757005371 1560 dbSNP
rs775829779 1568 dbSNP
rs1026105850 1578 dbSNP
rs1211927962 1584 dbSNP
rs1171451887 1586 dbSNP
rs1265032488 1589 dbSNP
rs561767294 1594 dbSNP
rs1043201860 1607 dbSNP
rs1276915990 1615 dbSNP
rs528931513 1616 dbSNP
rs983801331 1620 dbSNP
rs504963 1621 dbSNP
rs1388164400 1629 dbSNP
rs1469648493 1638 dbSNP
rs1425484126 1639 dbSNP
rs1157115869 1644 dbSNP
rs559452485 1649 dbSNP
rs1014660231 1650 dbSNP
rs1247147416 1650 dbSNP
rs1201111852 1654 dbSNP
rs533077109 1658 dbSNP
rs1449897380 1659 dbSNP
rs754232109 1661 dbSNP
rs1298568983 1662 dbSNP
rs1025763227 1668 dbSNP
rs762322228 1669 dbSNP
rs1256551438 1671 dbSNP
rs979807232 1676 dbSNP
rs1016070706 1678 dbSNP
rs927034680 1680 dbSNP
rs1328820599 1689 dbSNP
rs1322537929 1690 dbSNP
rs1331199154 1696 dbSNP
rs541324964 1696 dbSNP
rs1402276916 1704 dbSNP
rs187037538 1705 dbSNP
rs1306695312 1706 dbSNP
rs1425823591 1707 dbSNP
rs938444441 1720 dbSNP
rs1174215875 1725 dbSNP
rs1477109467 1730 dbSNP
rs632111 1734 dbSNP
rs535921375 1739 dbSNP
rs533141410 1740 dbSNP
rs1291510670 1742 dbSNP
rs565774262 1742 dbSNP
rs758805915 1750 dbSNP
rs1198434265 1752 dbSNP
rs1043722819 1756 dbSNP
rs1487677312 1759 dbSNP
rs503279 1766 dbSNP
rs1268622448 1774 dbSNP
rs1281403091 1779 dbSNP
rs987534913 1799 dbSNP
rs913020166 1814 dbSNP
rs752457081 1818 dbSNP
rs1039883465 1821 dbSNP
rs945757848 1835 dbSNP
rs1176830589 1839 dbSNP
rs748168746 1840 dbSNP
rs772690444 1844 dbSNP
rs1378676002 1845 dbSNP
rs1240324333 1849 dbSNP
rs1306570672 1852 dbSNP
rs1445825176 1854 dbSNP
rs978905912 1855 dbSNP
rs901264292 1859 dbSNP
rs1163091943 1860 dbSNP
rs1401322567 1864 dbSNP
rs1159338483 1868 dbSNP
rs998700861 1869 dbSNP
rs1025630444 1873 dbSNP
rs896050733 1878 dbSNP
rs1239570372 1881 dbSNP
rs1456150417 1886 dbSNP
rs567647108 1887 dbSNP
rs1355184752 1888 dbSNP
rs1047469408 1895 dbSNP
rs1222837290 1896 dbSNP
rs1379703899 1898 dbSNP
rs137925114 1899 dbSNP
rs780399149 1900 dbSNP
rs1328687057 1905 dbSNP
rs1378394534 1908 dbSNP
rs1016192049 1909 dbSNP
rs553341251 1916 dbSNP
rs1358681959 1918 dbSNP
rs567788105 1918 dbSNP
rs963170978 1920 dbSNP
rs979921963 1922 dbSNP
rs755508772 1937 dbSNP
rs1034221896 1948 dbSNP
rs959797097 1949 dbSNP
rs993001392 1953 dbSNP
rs571371853 1954 dbSNP
rs538768527 1956 dbSNP
rs1028943861 1957 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uaCAUCCGGAAAUCUAgugaa 5'
            ||:||    |:|||     
Target 5' ggGUGGG----UGGAU----- 3'
5 - 16
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000425340.2 | 3UTR | GCCAGGGUGGGUGGAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BLCA -0.992 0.04 -1.000 0.5 3 Click to see details
HNSC 0.501 0.13 0.321 0.24 7 Click to see details
UCEC 0.879 0.16 1.000 0.5 3 Click to see details
BRCA 0.269 0.41 -0.500 0.33 3 Click to see details
BRCA 0.269 0.41 -0.500 0.33 3 Click to see details
BRCA 0.269 0.41 -0.500 0.33 3 Click to see details
BRCA 0.269 0.41 -0.500 0.33 3 Click to see details
BRCA 0.269 0.41 -0.500 0.33 3 Click to see details
109 hsa-miR-1245a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006574 BRCA2 BRCA2, DNA repair associated 2 1
MIRT055432 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT063879 RASSF8 Ras association domain family member 8 2 6
MIRT077025 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT095775 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT099172 MAP3K4 mitogen-activated protein kinase kinase kinase 4 2 2
MIRT175616 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT456518 LYPLAL1 lysophospholipase like 1 2 2
MIRT464457 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465747 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT468257 SFXN4 sideroflexin 4 2 2
MIRT469216 RICTOR RPTOR independent companion of MTOR complex 2 2 2
MIRT472045 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT481795 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT500154 CREBBP CREB binding protein 2 2
MIRT506514 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 4
MIRT506915 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT513901 GRB10 growth factor receptor bound protein 10 2 6
MIRT519128 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT528121 FOXH1 forkhead box H1 2 2
MIRT528942 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT540580 CEP89 centrosomal protein 89 2 2
MIRT545858 ZNF264 zinc finger protein 264 2 4
MIRT547147 PGM3 phosphoglucomutase 3 2 2
MIRT547434 MED4 mediator complex subunit 4 2 2
MIRT554650 ROBO1 roundabout guidance receptor 1 2 2
MIRT558524 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT559762 ABHD5 abhydrolase domain containing 5 2 2
MIRT560438 GOLGA7B golgin A7 family member B 2 2
MIRT561974 LRRC59 leucine rich repeat containing 59 2 2
MIRT562442 DDIT4 DNA damage inducible transcript 4 2 2
MIRT563489 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT568265 BMP2K BMP2 inducible kinase 2 2
MIRT572522 KIAA0232 KIAA0232 2 2
MIRT612801 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT621533 ZNF507 zinc finger protein 507 2 2
MIRT625205 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT625615 ZNF84 zinc finger protein 84 2 2
MIRT629215 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629509 AS3MT arsenite methyltransferase 2 2
MIRT629769 STK25 serine/threonine kinase 25 2 2
MIRT630908 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT632508 RAB13 RAB13, member RAS oncogene family 2 2
MIRT636871 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT637106 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637332 FAM9B family with sequence similarity 9 member B 2 2
MIRT637553 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637639 ZNF431 zinc finger protein 431 2 2
MIRT637836 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT638326 RNF11 ring finger protein 11 2 2
MIRT638393 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT642450 CLUAP1 clusterin associated protein 1 2 2
MIRT642616 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT643133 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644324 NFKBID NFKB inhibitor delta 2 2
MIRT645150 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT645673 ADK adenosine kinase 2 2
MIRT646091 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646858 SLC35E4 solute carrier family 35 member E4 2 2
MIRT650153 ZNF426 zinc finger protein 426 2 2
MIRT652483 TMEM181 transmembrane protein 181 2 2
MIRT653790 SIRPA signal regulatory protein alpha 2 2
MIRT655526 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT657077 JPH2 junctophilin 2 2 2
MIRT657322 HOOK3 hook microtubule tethering protein 3 2 2
MIRT662036 FUT2 fucosyltransferase 2 2 2
MIRT662322 ADM2 adrenomedullin 2 2 2
MIRT663211 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663559 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663937 ZNF554 zinc finger protein 554 2 2
MIRT664689 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT664709 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT665291 ZFP14 ZFP14 zinc finger protein 2 2
MIRT665572 TXNL1 thioredoxin like 1 2 2
MIRT667068 PAOX polyamine oxidase 2 2
MIRT667304 MYO5A myosin VA 2 2
MIRT667442 METTL14 methyltransferase like 14 2 2
MIRT668048 GTPBP10 GTP binding protein 10 2 2
MIRT669604 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT671088 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT674361 SLC35E3 solute carrier family 35 member E3 2 2
MIRT674962 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT676394 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676819 AGMAT agmatinase 2 2
MIRT676891 ENSA endosulfine alpha 2 2
MIRT677059 ZNF34 zinc finger protein 34 2 2
MIRT678424 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678735 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT678930 XPOT exportin for tRNA 2 2
MIRT678954 MYADM myeloid associated differentiation marker 2 2
MIRT679228 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679765 TLR6 toll like receptor 6 2 2
MIRT681992 HRH4 histamine receptor H4 2 2
MIRT687405 NSUN4 NOP2/Sun RNA methyltransferase family member 4 2 2
MIRT694570 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT698449 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT706406 HAS2 hyaluronan synthase 2 2 2
MIRT706582 ZNF432 zinc finger protein 432 2 2
MIRT706838 VHLL VHL like 2 2
MIRT706909 DVL3 dishevelled segment polarity protein 3 2 2
MIRT707052 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT708583 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT708988 CABP4 calcium binding protein 4 2 2
MIRT713041 ADRA2B adrenoceptor alpha 2B 2 2
MIRT713731 SUCO SUN domain containing ossification factor 2 2
MIRT714968 RAB21 RAB21, member RAS oncogene family 2 2
MIRT717485 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT722826 KLK2 kallikrein related peptidase 2 2 2
MIRT723305 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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