pre-miRNA Information
pre-miRNA hsa-mir-412   
Genomic Coordinates chr14: 101065447 - 101065537
Synonyms MIRN412, hsa-mir-412, MIR412
Description Homo sapiens miR-412 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-412-3p
Sequence 54| ACUUCACCUGGUCCACUAGCCGU |76
Evidence Not_experimental
Experiments
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
rs61992671 18 GWAS
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369997462 1 dbSNP
rs1439693090 7 dbSNP
rs1301668924 11 dbSNP
rs534204576 13 dbSNP
rs775386036 14 dbSNP
rs762832140 15 dbSNP
rs1203323285 16 dbSNP
rs61992671 18 dbSNP
rs1022012324 19 dbSNP
rs1207609936 20 dbSNP
rs139967426 21 dbSNP
rs539487075 22 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol IL2RA   
Synonyms CD25, IDDM10, IL2R, IMD41, TCGFR, p55
Description interleukin 2 receptor subunit alpha
Transcript NM_000417   
Expression
Putative miRNA Targets on IL2RA
3'UTR of IL2RA
(miRNA target sites are highlighted)
>IL2RA|NM_000417|3'UTR
   1 AAAACCAAAAGAACAAGAATTTCTTGGTAAGAAGCCGGGAACAGACAACAGAAGTCATGAAGCCCAAGTGAAATCAAAGG
  81 TGCTAAATGGTCGCCCAGGAGACATCCGTTGTGCTTGCCTGCGTTTTGGAAGCTCTGAAGTCACATCACAGGACACGGGG
 161 CAGTGGCAACCTTGTCTCTATGCCAGCTCAGTCCCATCAGAGAGCGAGCGCTACCCACTTCTAAATAGCAATTTCGCCGT
 241 TGAAGAGGAAGGGCAAAACCACTAGAACTCTCCATCTTATTTTCATGTATATGTGTTCATTAAAGCATGAATGGTATGGA
 321 ACTCTCTCCACCCTATATGTAGTATAAAGAAAAGTAGGTTTACATTCATCTCATTCCAACTTCCCAGTTCAGGAGTCCCA
 401 AGGAAAGCCCCAGCACTAACGTAAATACACAACACACACACTCTACCCTATACAACTGGACATTGTCTGCGTGGTTCCTT
 481 TCTCAGCCGCTTCTGACTGCTGATTCTCCCGTTCACGTTGCCTAATAAACATCCTTCAAGAACTCTGGGCTGCTACCCAG
 561 AAATCATTTTACCCTTGGCTCAATCCTCTAAGCTAACCCCCTTCTACTGAGCCTTCAGTCTTGAATTTCTAAAAAACAGA
 641 GGCCATGGCAGAATAATCTTTGGGTAACTTCAAAACGGGGCAGCCAAACCCATGAGGCAATGTCAGGAACAGAAGGATGA
 721 ATGAGGTCCCAGGCAGAGAATCATACTTAGCAAAGTTTTACCTGTGCGTTACTAATTGGCCTCTTTAAGAGTTAGTTTCT
 801 TTGGGATTGCTATGAATGATACCCTGAATTTGGCCTGCACTAATTTGATGTTTACAGGTGGACACACAAGGTGCAAATCA
 881 ATGCGTACGTTTCCTGAGAAGTGTCTAAAAACACCAAAAAGGGATCCGTACATTCAATGTTTATGCAAGGAAGGAAAGAA
 961 AGAAGGAAGTGAAGAGGGAGAAGGGATGGAGGTCACACTGGTAGAACGTAACCACGGAAAAGAGCGCATCAGGCCTGGCA
1041 CGGTGGCTCAGGCCTATAACCCCAGCTCCCTAGGAGACCAAGGCGGGAGCATCTCTTGAGGCCAGGAGTTTGAGACCAGC
1121 CTGGGCAGCATAGCAAGACACATCCCTACAAAAAATTAGAAATTGGCTGGATGTGGTGGCATACGCCTGTAGTCCTAGCC
1201 ACTCAGGAGGCTGAGGCAGGAGGATTGCTTGAGCCCAGGAGTTCGAGGCTGCAGTCAGTCATGATGGCACCACTGCACTC
1281 CAGCCTGGGCAACAGAGCAAGATCCTGTCTTTAAGGAAAAAAAGACAAGATGAGCATACCAGCAGTCCTTGAACATTATC
1361 AAAAAGTTCAGCATATTAGAATCACCGGGAGGCCTTGTTAAAAGAGTTCGCTGGGCCCATCTTCAGAGTCTCTGAGTTGT
1441 TGGTCTGGAATAGAGCCAAATGTTTTGTGTGTCTAACAATTCCCAGGTGCTGTTGCTGCTGCTACTATTCCAGGAACACA
1521 CTTTGAGAACCATTGTGTTATTGCTCTGCACGCCCACCCACTCTCAACTCCCACGAAAAAAATCAACTTCCAGAGCTAAG
1601 ATTTCGGTGGAAGTCCTGGTTCCATATCTGGTGCAAGATCTCCCCTCACGAATCAGTTGAGTCAACATTCTAGCTCAACA
1681 ACATCACACGATTAACATTAACGAAAATTATTCATTTGGGAAACTATCAGCCAGTTTTCACTTCTGAAGGGGCAGGAGAG
1761 TGTTATGAGAAATCACGGCAGTTTTCAGCAGGGTCCAGATTCAGATTAAATAACTATTTTCTGTCATTTCTGTGACCAAC
1841 CACATACAAACAGACTCATCTGTGCACTCTCCCCCTCCCCCTTCAGGTATATGTTTTCTGAGTAAAGTTGAAAAGAATCT
1921 CAGACCAGAAAATATAGATATATATTTAAATCTTACTTGAGTAGAACTGATTACGACTTTTGGGTGTTGAGGGGTCTATA
2001 AGATCAAAACTTTTCCATGATAATACTAAGATGTTATCGACCATTTATCTGTCCTTCTCTCAAAAGTGTATGGTGGAATT
2081 TTCCAGAAGCTATGTGATACGTGATGATGTCATCACTCTGCTGTTAACATATAATAAATTTATTGCTATTGTTTATAAAA
2161 GAATAAATGATATTTTTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugccgaUCACCUGGUCCACUUCa 5'
                |||| |  :|| |||| 
Target 5' gaaggaAGTGAAGAGGGAGAAGg 3'
962 - 984 125.00 -12.40
2
miRNA  3' ugcCGAUCACCUGGUCCACUUCa 5'
             || | |  :|| | ||||| 
Target 5' ataGCAATTTCGCC-GTTGAAGa 3'
225 - 246 119.00 -6.60
3
miRNA  3' ugccGAUCA---CCUGGUCCAC-UUCa 5'
              ||:||     |:| |||| ||| 
Target 5' agtcCTGGTTCCATATCTGGTGCAAGa 3'
1612 - 1638 119.00 -12.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
880360 55 ClinVar
300248 70 ClinVar
300247 93 ClinVar
300246 103 ClinVar
300245 107 ClinVar
880359 183 ClinVar
880358 261 ClinVar
300244 412 ClinVar
300243 414 ClinVar
300242 444 ClinVar
879158 471 ClinVar
879157 513 ClinVar
879156 599 ClinVar
300241 672 ClinVar
300240 676 ClinVar
300239 677 ClinVar
879155 752 ClinVar
300238 767 ClinVar
300237 884 ClinVar
300236 888 ClinVar
300235 889 ClinVar
878565 895 ClinVar
878564 963 ClinVar
300234 969 ClinVar
300233 1008 ClinVar
878563 1024 ClinVar
300231 1026 ClinVar
300232 1026 ClinVar
300230 1041 ClinVar
877538 1042 ClinVar
877537 1044 ClinVar
300229 1061 ClinVar
877536 1084 ClinVar
300228 1159 ClinVar
300227 1186 ClinVar
300226 1267 ClinVar
880320 1426 ClinVar
880319 1443 ClinVar
300225 1454 ClinVar
300224 1461 ClinVar
880318 1500 ClinVar
300223 1539 ClinVar
300222 1549 ClinVar
300221 1574 ClinVar
300220 1575 ClinVar
879104 1619 ClinVar
879103 1643 ClinVar
300219 1650 ClinVar
300218 1672 ClinVar
300217 1702 ClinVar
879102 1766 ClinVar
300216 1772 ClinVar
300215 1880 ClinVar
300214 1974 ClinVar
300213 1994 ClinVar
300212 2055 ClinVar
300211 2108 ClinVar
878519 2131 ClinVar
878518 2144 ClinVar
300210 2178 ClinVar
COSN31547228 23 COSMIC
COSN30492974 49 COSMIC
COSN30465005 59 COSMIC
COSN31524140 64 COSMIC
COSN30131956 75 COSMIC
COSN19749042 84 COSMIC
COSN30167310 91 COSMIC
COSN30112916 93 COSMIC
COSN30491609 106 COSMIC
COSN13278696 123 COSMIC
COSN30187137 156 COSMIC
COSN29138399 209 COSMIC
COSN30137491 210 COSMIC
COSN30177292 214 COSMIC
COSN31527056 231 COSMIC
COSN8187552 497 COSMIC
COSN30288392 1254 COSMIC
COSN15381950 1409 COSMIC
COSN8715020 1643 COSMIC
COSN8715019 1741 COSMIC
COSN31778806 1755 COSMIC
COSN8715018 1862 COSMIC
COSN17182184 1961 COSMIC
COSN22430017 1992 COSMIC
rs12722605 1672 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs752490211 5 dbSNP
rs920592834 7 dbSNP
rs746347754 13 dbSNP
rs1311058776 23 dbSNP
rs769795224 29 dbSNP
rs372312640 36 dbSNP
rs747854116 37 dbSNP
rs1318477027 42 dbSNP
rs778662335 46 dbSNP
rs575663406 50 dbSNP
rs12722713 55 dbSNP
rs1302503374 58 dbSNP
rs1435269946 59 dbSNP
rs547047548 61 dbSNP
rs1311349488 67 dbSNP
rs12722600 70 dbSNP
rs1246565596 75 dbSNP
rs972136274 92 dbSNP
rs886047081 93 dbSNP
rs1172674351 96 dbSNP
rs753838977 99 dbSNP
rs886047080 103 dbSNP
rs749452297 104 dbSNP
rs12722714 107 dbSNP
rs1423198256 108 dbSNP
rs1012922758 117 dbSNP
rs1490952194 118 dbSNP
rs1269992429 121 dbSNP
rs1456561434 122 dbSNP
rs549892288 123 dbSNP
rs1390799538 144 dbSNP
rs531582979 149 dbSNP
rs1023976376 157 dbSNP
rs560898947 166 dbSNP
rs1053883274 178 dbSNP
rs1399476668 180 dbSNP
rs1013475322 181 dbSNP
rs542942584 183 dbSNP
rs1397200896 186 dbSNP
rs572213760 202 dbSNP
rs1349486650 204 dbSNP
rs367718232 205 dbSNP
rs1330180795 206 dbSNP
rs535911457 209 dbSNP
rs999339677 210 dbSNP
rs903627253 215 dbSNP
rs866767255 225 dbSNP
rs1201094583 227 dbSNP
rs1040799650 235 dbSNP
rs943884205 236 dbSNP
rs1043477456 238 dbSNP
rs559720581 239 dbSNP
rs1419412833 241 dbSNP
rs931239603 259 dbSNP
rs1467188803 273 dbSNP
rs185829590 274 dbSNP
rs1302918155 286 dbSNP
rs919824754 287 dbSNP
rs1407633829 288 dbSNP
rs1309423645 289 dbSNP
rs756213567 305 dbSNP
rs751588150 314 dbSNP
rs973840090 321 dbSNP
rs1299888790 322 dbSNP
rs12722715 323 dbSNP
rs1282450726 328 dbSNP
rs910851011 330 dbSNP
rs1398630638 332 dbSNP
rs1482080927 333 dbSNP
rs1050646874 335 dbSNP
rs1462566584 336 dbSNP
rs1252758688 337 dbSNP
rs1399590711 339 dbSNP
rs1480847709 342 dbSNP
rs933546058 355 dbSNP
rs866534259 363 dbSNP
rs1190386036 375 dbSNP
rs982154177 383 dbSNP
rs34686279 386 dbSNP
rs1434827393 387 dbSNP
rs923460298 393 dbSNP
rs574873827 395 dbSNP
rs1389020679 399 dbSNP
rs970752915 408 dbSNP
rs886047079 412 dbSNP
rs886047078 414 dbSNP
rs1168828216 420 dbSNP
rs1481571402 421 dbSNP
rs1024227901 426 dbSNP
rs972229492 429 dbSNP
rs990982402 436 dbSNP
rs958546994 440 dbSNP
rs12722601 444 dbSNP
rs1297424486 445 dbSNP
rs1340171302 449 dbSNP
rs768574986 453 dbSNP
rs1275677603 458 dbSNP
rs181357994 461 dbSNP
rs909326184 462 dbSNP
rs1220636834 464 dbSNP
rs1244782119 465 dbSNP
rs984852514 470 dbSNP
rs553112485 471 dbSNP
rs1196816714 477 dbSNP
rs188613092 478 dbSNP
rs1447190806 482 dbSNP
rs1023612429 483 dbSNP
rs1419872892 487 dbSNP
rs576607759 488 dbSNP
rs1255544053 489 dbSNP
rs1351988394 499 dbSNP
rs1204990101 503 dbSNP
rs1323861297 510 dbSNP
rs960634389 511 dbSNP
rs1230867431 512 dbSNP
rs554828895 516 dbSNP
rs1050038084 517 dbSNP
rs931147337 521 dbSNP
rs898429956 533 dbSNP
rs1267471412 543 dbSNP
rs1463487202 551 dbSNP
rs1190009557 552 dbSNP
rs1242207203 554 dbSNP
rs1472139069 555 dbSNP
rs1179785584 560 dbSNP
rs1415445782 573 dbSNP
rs1475765686 575 dbSNP
rs56206280 582 dbSNP
rs1445897036 583 dbSNP
rs1374546219 597 dbSNP
rs541601070 599 dbSNP
rs1387174069 604 dbSNP
rs536972453 605 dbSNP
rs903683997 606 dbSNP
rs764877940 609 dbSNP
rs1006609925 612 dbSNP
rs1445854762 623 dbSNP
rs1286226144 630 dbSNP
rs1407195307 633 dbSNP
rs907888953 634 dbSNP
rs1326744916 636 dbSNP
rs982040171 658 dbSNP
rs949490384 659 dbSNP
rs916642780 660 dbSNP
rs1464859479 661 dbSNP
rs1485790362 663 dbSNP
rs1181979489 664 dbSNP
rs991426557 668 dbSNP
rs886047077 672 dbSNP
rs566194606 676 dbSNP
rs12719919 677 dbSNP
rs1050695706 679 dbSNP
rs1412881006 681 dbSNP
rs1336243109 692 dbSNP
rs1376357524 693 dbSNP
rs933640701 698 dbSNP
rs1306338051 702 dbSNP
rs76471890 706 dbSNP
rs75779793 707 dbSNP
rs1348434286 708 dbSNP
rs76242406 709 dbSNP
rs1240857306 711 dbSNP
rs1439672181 715 dbSNP
rs1280113847 716 dbSNP
rs1344175058 722 dbSNP
rs1217033352 726 dbSNP
rs1280105926 727 dbSNP
rs1347893105 736 dbSNP
rs1336272043 746 dbSNP
rs41290329 752 dbSNP
rs1036569161 756 dbSNP
rs143416542 767 dbSNP
rs909348135 768 dbSNP
rs985292993 773 dbSNP
rs948136085 776 dbSNP
rs549930913 786 dbSNP
rs1174770067 791 dbSNP
rs1277484044 792 dbSNP
rs1395772529 802 dbSNP
rs1429139963 815 dbSNP
rs1198332255 816 dbSNP
rs1352602578 824 dbSNP
rs531419003 838 dbSNP
rs1239124450 840 dbSNP
rs1019307368 856 dbSNP
rs1351508542 871 dbSNP
rs1317063851 875 dbSNP
rs916647121 877 dbSNP
rs1454665255 883 dbSNP
rs886047076 884 dbSNP
rs760142892 885 dbSNP
rs12722716 888 dbSNP
rs147669116 889 dbSNP
rs1227002858 890 dbSNP
rs1272091677 903 dbSNP
rs1159669307 917 dbSNP
rs1196803612 924 dbSNP
rs1289633280 927 dbSNP
rs968296462 928 dbSNP
rs775924333 929 dbSNP
rs1201685861 931 dbSNP
rs1254120377 938 dbSNP
rs1448990704 940 dbSNP
rs1186717922 942 dbSNP
rs1392326768 944 dbSNP
rs12722717 953 dbSNP
rs1462674086 961 dbSNP
rs527589024 963 dbSNP
rs1389751446 965 dbSNP
rs939943430 965 dbSNP
rs759899126 966 dbSNP
rs12722602 969 dbSNP
rs1433807020 970 dbSNP
rs1046396172 977 dbSNP
rs1294753025 978 dbSNP
rs1184754937 984 dbSNP
rs544896196 986 dbSNP
rs1448414072 992 dbSNP
rs997842886 996 dbSNP
rs1227709205 998 dbSNP
rs949376143 1007 dbSNP
rs34164172 1008 dbSNP
rs1215706035 1012 dbSNP
rs1215916391 1014 dbSNP
rs1055214907 1015 dbSNP
rs936715109 1016 dbSNP
rs12722718 1024 dbSNP
rs28360484 1026 dbSNP
rs912803984 1034 dbSNP
rs1366914842 1038 dbSNP
rs141524746 1041 dbSNP
rs1471713662 1041 dbSNP
rs542812308 1042 dbSNP
rs572589682 1044 dbSNP
rs781076912 1047 dbSNP
rs1382248207 1055 dbSNP
rs55885853 1061 dbSNP
rs1338303184 1068 dbSNP
rs149796519 1069 dbSNP
rs962737707 1071 dbSNP
rs571299400 1075 dbSNP
rs1003974783 1076 dbSNP
rs1305512354 1084 dbSNP
rs374118462 1085 dbSNP
rs1262970870 1087 dbSNP
rs537968636 1100 dbSNP
rs1014045828 1118 dbSNP
rs1199914727 1119 dbSNP
rs745755601 1120 dbSNP
rs895143394 1130 dbSNP
rs1486770995 1134 dbSNP
rs1413667780 1158 dbSNP
rs543983290 1159 dbSNP
rs1418315161 1164 dbSNP
rs1472119288 1165 dbSNP
rs936785292 1174 dbSNP
rs567205124 1176 dbSNP
rs1453903761 1183 dbSNP
rs925329636 1184 dbSNP
rs923906350 1185 dbSNP
rs12722603 1186 dbSNP
rs1313034744 1192 dbSNP
rs1350284230 1193 dbSNP
rs967967407 1207 dbSNP
rs1408333317 1210 dbSNP
rs1022617157 1214 dbSNP
rs945508248 1216 dbSNP
rs1318048444 1223 dbSNP
rs985341613 1229 dbSNP
rs953874339 1233 dbSNP
rs370765858 1234 dbSNP
rs1211906588 1236 dbSNP
rs1270711095 1244 dbSNP
rs527536271 1250 dbSNP
rs1482634040 1253 dbSNP
rs987042934 1260 dbSNP
rs115247277 1261 dbSNP
rs1419585371 1262 dbSNP
rs1451004232 1266 dbSNP
rs1570538 1267 dbSNP
rs896837610 1270 dbSNP
rs1435993039 1272 dbSNP
rs1173898853 1275 dbSNP
rs533020456 1277 dbSNP
rs1369525813 1280 dbSNP
rs1408459730 1295 dbSNP
rs1300254663 1302 dbSNP
rs1015233762 1303 dbSNP
rs1005611743 1305 dbSNP
rs1299770374 1312 dbSNP
rs1279083301 1313 dbSNP
rs529774081 1315 dbSNP
rs1373318134 1318 dbSNP
rs1235088665 1324 dbSNP
rs151183621 1324 dbSNP
rs1340295157 1330 dbSNP
rs763727948 1332 dbSNP
rs1202254013 1337 dbSNP
rs12722719 1343 dbSNP
rs1012459364 1349 dbSNP
rs1190575849 1354 dbSNP
rs1437627148 1359 dbSNP
rs1349871726 1365 dbSNP
rs1004027145 1370 dbSNP
rs755674960 1373 dbSNP
rs555259758 1378 dbSNP
rs1455229690 1380 dbSNP
rs1441763562 1386 dbSNP
rs1056570859 1387 dbSNP
rs1407877288 1390 dbSNP
rs774337279 1390 dbSNP
rs939388737 1393 dbSNP
rs1355513026 1398 dbSNP
rs1169542368 1409 dbSNP
rs1397287800 1410 dbSNP
rs923957065 1415 dbSNP
rs1441821624 1420 dbSNP
rs143496123 1428 dbSNP
rs946697468 1443 dbSNP
rs1216550929 1445 dbSNP
rs1296510516 1446 dbSNP
rs886047075 1454 dbSNP
rs1307879011 1457 dbSNP
rs752262905 1459 dbSNP
rs12244380 1461 dbSNP
rs1244925382 1471 dbSNP
rs953887284 1487 dbSNP
rs1012835968 1492 dbSNP
rs1469757461 1496 dbSNP
rs894358573 1500 dbSNP
rs1439655817 1501 dbSNP
rs1474118992 1503 dbSNP
rs1187925682 1504 dbSNP
rs1258852375 1525 dbSNP
rs760118576 1528 dbSNP
rs1316362802 1533 dbSNP
rs1163217859 1534 dbSNP
rs1055143949 1535 dbSNP
rs148885460 1539 dbSNP
rs71390108 1539 dbSNP
rs886047074 1539 dbSNP
rs1320390425 1547 dbSNP
rs12722604 1549 dbSNP
rs961133114 1551 dbSNP
rs945560714 1552 dbSNP
rs1273607911 1557 dbSNP
rs891307572 1558 dbSNP
rs886047073 1574 dbSNP
rs886047072 1575 dbSNP
rs952479194 1579 dbSNP
rs1233860700 1583 dbSNP
rs932937510 1583 dbSNP
rs1267374011 1584 dbSNP
rs1444829596 1586 dbSNP
rs1217273569 1588 dbSNP
rs766898254 1589 dbSNP
rs763406166 1599 dbSNP
rs1444937808 1605 dbSNP
rs1482716118 1606 dbSNP
rs1185271445 1609 dbSNP
rs1012472415 1610 dbSNP
rs1475714754 1611 dbSNP
rs895330376 1618 dbSNP
rs773626989 1619 dbSNP
rs1159097022 1628 dbSNP
rs921487054 1638 dbSNP
rs770156563 1640 dbSNP
rs184686521 1649 dbSNP
rs886047071 1650 dbSNP
rs1003697602 1652 dbSNP
rs867792991 1656 dbSNP
rs1042859315 1662 dbSNP
rs1314960236 1665 dbSNP
rs1357160334 1670 dbSNP
rs1415147168 1671 dbSNP
rs12722605 1672 dbSNP
rs915191823 1676 dbSNP
rs1225026057 1681 dbSNP
rs1413705111 1684 dbSNP
rs908341102 1689 dbSNP
rs1422752905 1690 dbSNP
rs879214554 1691 dbSNP
rs1208319152 1697 dbSNP
rs1259114643 1701 dbSNP
rs12722606 1702 dbSNP
rs971089935 1703 dbSNP
rs1231739213 1704 dbSNP
rs1440281298 1711 dbSNP
rs1471451264 1723 dbSNP
rs932544897 1725 dbSNP
rs1424593976 1729 dbSNP
rs1432894145 1745 dbSNP
rs1175815474 1754 dbSNP
rs922502446 1756 dbSNP
rs976583673 1757 dbSNP
rs961187614 1766 dbSNP
rs74973937 1772 dbSNP
rs1333708219 1776 dbSNP
rs542143897 1777 dbSNP
rs952421681 1785 dbSNP
rs1280027166 1795 dbSNP
rs556200257 1804 dbSNP
rs958677529 1810 dbSNP
rs1231405270 1814 dbSNP
rs537404393 1816 dbSNP
rs1023025956 1823 dbSNP
rs1348145432 1824 dbSNP
rs546491159 1827 dbSNP
rs1271333004 1843 dbSNP
rs1439883088 1849 dbSNP
rs1183198482 1853 dbSNP
rs1452703721 1855 dbSNP
rs1195578323 1859 dbSNP
rs1395983259 1863 dbSNP
rs1449103231 1873 dbSNP
rs1000912499 1877 dbSNP
rs12722607 1880 dbSNP
rs1411401032 1881 dbSNP
rs1225803394 1884 dbSNP
rs1020933054 1885 dbSNP
rs1393595443 1885 dbSNP
rs1009658185 1889 dbSNP
rs1309155854 1890 dbSNP
rs891193033 1898 dbSNP
rs1267999448 1904 dbSNP
rs1341975056 1907 dbSNP
rs1443955522 1917 dbSNP
rs1384280810 1927 dbSNP
rs1051285618 1963 dbSNP
rs932800261 1968 dbSNP
rs12722720 1974 dbSNP
rs555221196 1975 dbSNP
rs1039025708 1976 dbSNP
rs1003749869 1980 dbSNP
rs902680302 1984 dbSNP
rs12722608 1994 dbSNP
rs1161104131 2000 dbSNP
rs192145132 2002 dbSNP
rs1011378465 2004 dbSNP
rs1168274480 2011 dbSNP
rs949814842 2013 dbSNP
rs1459815382 2016 dbSNP
rs1327796959 2017 dbSNP
rs1394615047 2018 dbSNP
rs761805503 2033 dbSNP
rs551131164 2038 dbSNP
rs539350013 2039 dbSNP
rs1228689679 2044 dbSNP
rs573034970 2051 dbSNP
rs561032746 2055 dbSNP
rs550450134 2065 dbSNP
rs1040937753 2089 dbSNP
rs1333060071 2096 dbSNP
rs531654198 2100 dbSNP
rs908337333 2101 dbSNP
rs74895246 2108 dbSNP
rs1411691490 2109 dbSNP
rs1203429064 2112 dbSNP
rs1483072826 2121 dbSNP
rs549245031 2131 dbSNP
rs915644843 2132 dbSNP
rs991184251 2134 dbSNP
rs1256583917 2139 dbSNP
rs757107768 2144 dbSNP
rs1488789988 2149 dbSNP
rs979094426 2151 dbSNP
rs959689042 2152 dbSNP
rs1418451254 2154 dbSNP
rs1035313038 2161 dbSNP
rs1156292584 2166 dbSNP
rs1386419949 2172 dbSNP
rs982323438 2177 dbSNP
rs886047070 2178 dbSNP
rs1020985543 2179 dbSNP
rs1311856151 2179 dbSNP
rs1416985406 2183 dbSNP
rs749065694 2184 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ugccgaUCACCUGGUCCACUUCa 5'
                |||| |  :|| |||| 
Target 5' gaaggaAGUGAAGAGGGAGAAGg 3'
8 - 30
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000379959.3 | 3UTR | AAAGAAAGAAGGAAGUGAAGAGGGAGAAGGGAUGGAGGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
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138 hsa-miR-412-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005780 ACVR1C activin A receptor type 1C 1 1
MIRT062013 YOD1 YOD1 deubiquitinase 2 2
MIRT345112 ATXN7L3 ataxin 7 like 3 2 2
MIRT383735 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT396956 CELF1 CUGBP Elav-like family member 1 2 2
MIRT439280 XIAP X-linked inhibitor of apoptosis 1 1
MIRT439313 VAT1 vesicle amine transport 1 1 1
MIRT439375 TUBA1A tubulin alpha 1a 1 1
MIRT439418 TMOD1 tropomodulin 1 1 1
MIRT439503 SURF4 surfeit 4 1 1
MIRT439563 SON SON DNA binding protein 1 1
MIRT439598 SLC3A2 solute carrier family 3 member 2 1 1
MIRT439670 SETD1B SET domain containing 1B 1 1
MIRT439767 RMND5A required for meiotic nuclear division 5 homolog A 1 1
MIRT439922 PPL periplakin 1 1
MIRT439947 PLEKHA6 pleckstrin homology domain containing A6 1 1
MIRT439952 PLCB4 phospholipase C beta 4 1 1
MIRT439961 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT440005 PEG3 paternally expressed 3 1 1
MIRT440061 OSBPL8 oxysterol binding protein like 8 1 1
MIRT440166 MYH14 myosin heavy chain 14 1 1
MIRT440276 MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 1 1
MIRT440437 IPO13 importin 13 1 1
MIRT440441 INTS3 integrator complex subunit 3 1 1
MIRT440448 INS insulin 1 1
MIRT440461 IGF2R insulin like growth factor 2 receptor 1 1
MIRT440472 IARS isoleucyl-tRNA synthetase 1 1
MIRT440530 GUCY1A3 guanylate cyclase 1 soluble subunit alpha 1 1
MIRT440542 GOLGA2 golgin A2 1 1
MIRT440569 GIGYF1 GRB10 interacting GYF protein 1 1 1
MIRT440608 FTSJD2 cap methyltransferase 1 1 1
MIRT440750 EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1 1
MIRT440781 DOT1L DOT1 like histone lysine methyltransferase 1 1
MIRT440804 DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 1 1
MIRT440867 CSDE1 cold shock domain containing E1 1 1
MIRT440890 CPEB4 cytoplasmic polyadenylation element binding protein 4 1 1
MIRT440917 COL1A1 collagen type I alpha 1 chain 1 1
MIRT440967 CDH22 cadherin 22 1 1
MIRT440968 CDH2 cadherin 2 1 1
MIRT441024 CALR calreticulin 1 1
MIRT441278 ACTB actin beta 1 1
MIRT448421 TNFAIP3 TNF alpha induced protein 3 2 2
MIRT462833 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT465062 TSR1 TSR1, ribosome maturation factor 2 2
MIRT476050 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT485318 MZT1 mitotic spindle organizing protein 1 2 4
MIRT493584 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 6
MIRT494567 BAK1 BCL2 antagonist/killer 1 2 2
MIRT497393 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT503250 ZNF257 zinc finger protein 257 2 10
MIRT503656 ZNF138 zinc finger protein 138 2 10
MIRT505882 RNF219 ring finger protein 219 2 2
MIRT507525 DSTN destrin, actin depolymerizing factor 2 4
MIRT510663 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT514682 ZNF701 zinc finger protein 701 2 4
MIRT515370 ZNF208 zinc finger protein 208 2 6
MIRT525237 KCNJ12 potassium voltage-gated channel subfamily J member 12 2 2
MIRT527963 MTAP methylthioadenosine phosphorylase 2 2
MIRT528482 STAMBPL1 STAM binding protein like 1 2 2
MIRT529909 C1orf64 steroid receptor associated and regulated protein 2 4
MIRT531558 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT532234 KLF2 Kruppel like factor 2 2 4
MIRT532480 HOXA13 homeobox A13 2 2
MIRT535544 P2RY2 purinergic receptor P2Y2 2 2
MIRT547311 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT551795 ZNF117 zinc finger protein 117 2 4
MIRT554939 RAP1A RAP1A, member of RAS oncogene family 2 2
MIRT558171 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT568771 LY6K lymphocyte antigen 6 family member K 2 2
MIRT570766 ZNF99 zinc finger protein 99 2 2
MIRT572405 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT573396 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT610403 RXRB retinoid X receptor beta 2 2
MIRT610886 SCN8A sodium voltage-gated channel alpha subunit 8 2 2
MIRT611197 TMEM105 transmembrane protein 105 2 2
MIRT611244 ZNF550 zinc finger protein 550 2 2
MIRT615669 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 4
MIRT617974 DOCK4 dedicator of cytokinesis 4 2 2
MIRT619150 ZNF326 zinc finger protein 326 2 2
MIRT619608 MKKS McKusick-Kaufman syndrome 2 2
MIRT621053 DGKD diacylglycerol kinase delta 2 2
MIRT623665 HRK harakiri, BCL2 interacting protein 2 2
MIRT624883 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT624939 MARCH2 membrane associated ring-CH-type finger 2 2 2
MIRT634198 TMOD2 tropomodulin 2 2 4
MIRT636727 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT637741 POLR3K RNA polymerase III subunit K 2 2
MIRT638002 ZC3H13 zinc finger CCCH-type containing 13 2 2
MIRT640395 ZNF785 zinc finger protein 785 2 2
MIRT640505 ANTXR1 anthrax toxin receptor 1 2 2
MIRT641293 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT641863 STOML1 stomatin like 1 2 2
MIRT642600 C14orf180 chromosome 14 open reading frame 180 2 2
MIRT642895 CASP1 caspase 1 2 2
MIRT643967 FHL2 four and a half LIM domains 2 2 4
MIRT645237 KCTD12 potassium channel tetramerization domain containing 12 2 2
MIRT646621 CENPL centromere protein L 2 2
MIRT648620 CYB561A3 cytochrome b561 family member A3 2 2
MIRT648908 ZNF551 zinc finger protein 551 2 2
MIRT649439 HIBADH 3-hydroxyisobutyrate dehydrogenase 2 2
MIRT650637 LTF lactotransferrin 2 2
MIRT650971 STARD3NL STARD3 N-terminal like 2 2
MIRT651067 ZNF518B zinc finger protein 518B 2 4
MIRT652384 TMEM55A phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2 2
MIRT653958 SEPN1 selenoprotein N 2 2
MIRT656885 KIF1C kinesin family member 1C 2 2
MIRT657965 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT658080 FOXR2 forkhead box R2 2 2
MIRT662570 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT663089 METTL10 EEF1A lysine methyltransferase 2 2 2
MIRT683705 ZNF195 zinc finger protein 195 2 2
MIRT683835 ZNF682 zinc finger protein 682 2 2
MIRT706811 APOL4 apolipoprotein L4 2 2
MIRT707575 DYNC2LI1 dynein cytoplasmic 2 light intermediate chain 1 2 2
MIRT708606 ZNF260 zinc finger protein 260 2 2
MIRT708859 TMSB4X thymosin beta 4, X-linked 2 2
MIRT709861 PDIK1L PDLIM1 interacting kinase 1 like 2 2
MIRT709987 RBM41 RNA binding motif protein 41 2 2
MIRT710098 KPNA5 karyopherin subunit alpha 5 2 2
MIRT710211 ENAH ENAH, actin regulator 2 2
MIRT710868 B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 2 2
MIRT710986 SUSD5 sushi domain containing 5 2 2
MIRT711460 RNF145 ring finger protein 145 2 2
MIRT712302 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT713609 SYTL4 synaptotagmin like 4 2 2
MIRT713789 MAK16 MAK16 homolog 2 2
MIRT715480 MYO9B myosin IXB 2 2
MIRT716328 POU5F1 POU class 5 homeobox 1 2 2
MIRT717252 TMEM246 transmembrane protein 246 2 2
MIRT718077 CLIC5 chloride intracellular channel 5 2 2
MIRT718463 EED embryonic ectoderm development 2 2
MIRT718645 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT718982 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT721078 RPS9 ribosomal protein S9 2 2
MIRT721419 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT721863 CENPJ centromere protein J 2 2
MIRT722492 PNKD paroxysmal nonkinesigenic dyskinesia 2 2
MIRT723391 CALN1 calneuron 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-412 Gemcitabine approved 60750 Northern blot Mz-ChA-1 human cholangiocarcinoma cell lines 16762633 2006 down-regulated
miR-412 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-412 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-412 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-412-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved sensitive High Anaplastic Thyroid Cancer tissue
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-412-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-412-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-412-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (Panc1-GR1)
hsa-miR-412-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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