pre-miRNA Information
pre-miRNA hsa-mir-6511b-1   
Genomic Coordinates chr16: 2106669 - 2106753
Description Homo sapiens miR-6511b-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-6511b-2   
Genomic Coordinates chr16: 15134075 - 15134145
Description Homo sapiens miR-6511b-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6511b-3p
Sequence 53| CCUCACCACCCCUUCUGCCUGCA |75
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
993639 5 ClinVar
1196654 15 ClinVar
256998 15 ClinVar
433980 16 ClinVar
586295 18 ClinVar
433979 19 ClinVar
COSM3948368 17 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs769351879 1 dbSNP
rs1001283562 2 dbSNP
rs763611191 3 dbSNP
rs1465530682 4 dbSNP
rs1227492873 4 dbSNP
rs745502224 5 dbSNP
rs551972801 6 dbSNP
rs538162642 6 dbSNP
rs751438298 7 dbSNP
rs1285683081 7 dbSNP
rs1340898267 8 dbSNP
rs4018164 9 dbSNP
rs370568831 9 dbSNP
rs1180919709 10 dbSNP
rs1339482497 10 dbSNP
rs758216756 11 dbSNP
rs1323026290 11 dbSNP
rs1239445091 12 dbSNP
rs1310601001 12 dbSNP
rs1431093969 13 dbSNP
rs752690118 15 dbSNP
rs1371790714 15 dbSNP
rs746463189 16 dbSNP
rs1209415208 17 dbSNP
rs761022804 17 dbSNP
rs1242038386 17 dbSNP
rs370411414 18 dbSNP
rs759723934 19 dbSNP
rs1428318191 19 dbSNP
rs1416441031 20 dbSNP
rs754040914 21 dbSNP
rs776062795 21 dbSNP
rs1273686335 22 dbSNP
rs1182772456 22 dbSNP
rs1472619959 23 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MED18   
Synonyms SRB5, p28b
Description mediator complex subunit 18
Transcript NM_001127350   
Other Transcripts NM_017638   
Expression
Putative miRNA Targets on MED18
3'UTR of MED18
(miRNA target sites are highlighted)
>MED18|NM_001127350|3'UTR
   1 CTAAGAGGATCTGTCCACATTTGGGGCCTATCCTTACTTGTTTGAAAAAATATGTTTGCTTTTTTTGGTTTTTGTTTTGT
  81 TTTGTTTTTGAGACAGAGTCTCGCTTTGTTTCCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAACCTCTGCC
 161 TCCTGGGTTCAAGCAATTCTCCCACCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACATGCCACCATGCTCAGCTAATT
 241 TTTGTATTTTTAGTAGAAATGGGGATTCACCATGTTGGTCAGGCTATTCTCGAACTCCTGACCTCGTGATCCACCCACCT
 321 TGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCTGGCCAAAAAAATATGTTTTAAATGTCCCATTTCAC
 401 CATTGCCAGGCAGGCATTCTTCCTTCAGGGAGAGGATGGTGAGAATTAATTGGTTCTTTGCACTGTTCTCCTCATGTGGC
 481 GATTTCACTTTCATGACAGCCTTTCTATATTAAAGGCTCAGGATGTCACGGAGAATCTATCTAATCCCACTGTATTAAGA
 561 GGGGAAACCGGGCCAAGCGCAGTGGCTCACACCTCTAATCCCAGCACTTTGGGAGGCTGAGGTAGGTGGATCACCCAAGG
 641 TCAGGAGTTTGAGACCAGCCTGGCCAAATGGTGAAACCCCATCTCTACGAAAAATACAAAATTTAGCCGGGCATGGTAGC
 721 AGGCGCTTGTAATCCCAGCTACTTGGGAGGCTGAGGCTGGAGAATCGCTTGAACCCAGGAGGTGAAGGTTGCAGTGACCA
 801 GAGATGACGCCATTGCACTCCAGCCTGGGTGAGAAGAGCGAAACTCCGTCTCAAAAAAAAATAAAAATGAAGAGGGGAAA
 881 CCAGAATAAATTATCTTTTGGAAAGGACAATTTCTTGTTTGGCCATTTGTGTATAAGGTTGGTAACATTAGAGGCTGTGA
 961 GCTTGTGTTACATGGTAATAAAGCCAATGAAGAGACA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acGUCCGUCUUCCCCACCACUCc 5'
            |||| |||  || ||||||| 
Target 5' ttCAGGGAGA--GGATGGTGAGa 3'
424 - 444 169.00 -23.20
2
miRNA  3' acGUCCGUCUUCCCCACCACUcc 5'
            | |||  ||    ||||||  
Target 5' gcCTGGCCAAA----TGGTGAaa 3'
658 - 676 127.00 -8.60
3
miRNA  3' acguccgucuuccccaCCACUCc 5'
                          |||||| 
Target 5' attgcactccagcctgGGTGAGa 3'
812 - 834 120.00 -11.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30568682 11 COSMIC
COSN30455710 33 COSMIC
COSN31547605 49 COSMIC
COSN30500468 51 COSMIC
COSN30548384 67 COSMIC
COSN28601885 96 COSMIC
COSN32081251 487 COSMIC
COSN19075854 596 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs769874643 2 dbSNP
rs749307872 3 dbSNP
rs767008923 5 dbSNP
rs934643226 17 dbSNP
rs753161862 19 dbSNP
rs1168374805 23 dbSNP
rs1441575583 25 dbSNP
rs761179287 28 dbSNP
rs764504648 31 dbSNP
rs754314223 32 dbSNP
rs773529721 33 dbSNP
rs1173100648 45 dbSNP
rs757674767 49 dbSNP
rs779316599 52 dbSNP
rs557439919 54 dbSNP
rs1281096888 55 dbSNP
rs1486725952 59 dbSNP
rs1316655928 62 dbSNP
rs1203623198 69 dbSNP
rs1326167329 70 dbSNP
rs1251641176 78 dbSNP
rs767570789 89 dbSNP
rs567621857 103 dbSNP
rs186269323 104 dbSNP
rs1231422958 107 dbSNP
rs1423549403 117 dbSNP
rs1345246754 120 dbSNP
rs934013509 125 dbSNP
rs1201870785 127 dbSNP
rs1052825974 135 dbSNP
rs1446171728 136 dbSNP
rs1188975704 138 dbSNP
rs1432208502 139 dbSNP
rs1173933135 141 dbSNP
rs190741784 142 dbSNP
rs890460843 143 dbSNP
rs1427341125 147 dbSNP
rs1479062977 153 dbSNP
rs1157008404 156 dbSNP
rs1011444109 163 dbSNP
rs1401594445 165 dbSNP
rs1354986936 167 dbSNP
rs1323038360 168 dbSNP
rs1392914048 177 dbSNP
rs1440876584 182 dbSNP
rs1444329972 198 dbSNP
rs943603552 204 dbSNP
rs1291540560 208 dbSNP
rs1022378429 219 dbSNP
rs1277341979 232 dbSNP
rs1349520538 236 dbSNP
rs1209105938 237 dbSNP
rs1039710837 238 dbSNP
rs1366705961 245 dbSNP
rs1268011865 247 dbSNP
rs1434917971 248 dbSNP
rs761015756 254 dbSNP
rs899318849 259 dbSNP
rs1422504197 260 dbSNP
rs1440423431 262 dbSNP
rs995001837 266 dbSNP
rs766583019 267 dbSNP
rs572883645 269 dbSNP
rs1026689647 270 dbSNP
rs1416210316 271 dbSNP
rs886820133 280 dbSNP
rs1327114847 288 dbSNP
rs1393521044 292 dbSNP
rs538428960 293 dbSNP
rs1002342080 304 dbSNP
rs1334797502 306 dbSNP
rs1228667851 307 dbSNP
rs1035336930 319 dbSNP
rs1332361025 327 dbSNP
rs1232464576 329 dbSNP
rs1035288579 332 dbSNP
rs960906842 338 dbSNP
rs971763519 349 dbSNP
rs369258343 355 dbSNP
rs1249960240 360 dbSNP
rs951743662 362 dbSNP
rs984969940 363 dbSNP
rs968530482 368 dbSNP
rs558295355 372 dbSNP
rs1245322003 374 dbSNP
rs1475045678 378 dbSNP
rs143360062 380 dbSNP
rs1193875705 392 dbSNP
rs924439574 395 dbSNP
rs1254420674 403 dbSNP
rs1165616112 409 dbSNP
rs776730265 420 dbSNP
rs1447305983 431 dbSNP
rs1409941021 436 dbSNP
rs1167371843 438 dbSNP
rs759588812 451 dbSNP
rs182645192 456 dbSNP
rs1419660324 457 dbSNP
rs1413932478 462 dbSNP
rs1313247152 463 dbSNP
rs1323399324 465 dbSNP
rs1411570456 468 dbSNP
rs1250715441 474 dbSNP
rs1162660570 481 dbSNP
rs975865836 482 dbSNP
rs987974173 485 dbSNP
rs1485500868 488 dbSNP
rs923195096 493 dbSNP
rs144845475 494 dbSNP
rs867347723 501 dbSNP
rs1327681848 502 dbSNP
rs892503690 502 dbSNP
rs946722853 503 dbSNP
rs543210895 504 dbSNP
rs1170008161 509 dbSNP
rs1373239751 521 dbSNP
rs1433212036 526 dbSNP
rs905252735 527 dbSNP
rs1002374693 530 dbSNP
rs1035150877 531 dbSNP
rs896647156 534 dbSNP
rs148574118 537 dbSNP
rs1026548445 540 dbSNP
rs575102622 542 dbSNP
rs1005858075 551 dbSNP
rs759346474 558 dbSNP
rs1278370949 562 dbSNP
rs1334774731 570 dbSNP
rs373363282 571 dbSNP
rs1017326215 575 dbSNP
rs964391408 579 dbSNP
rs529009069 580 dbSNP
rs923144385 596 dbSNP
rs1463241988 602 dbSNP
rs955898197 603 dbSNP
rs570680390 605 dbSNP
rs866498148 607 dbSNP
rs1242174691 608 dbSNP
rs946723716 618 dbSNP
rs1013029394 624 dbSNP
rs1389281935 625 dbSNP
rs1437233804 643 dbSNP
rs1301306305 648 dbSNP
rs1043691816 655 dbSNP
rs926700097 657 dbSNP
rs1461912148 663 dbSNP
rs938110896 669 dbSNP
rs141162063 679 dbSNP
rs758212434 689 dbSNP
rs764008477 690 dbSNP
rs1386237297 695 dbSNP
rs751311184 697 dbSNP
rs538105862 698 dbSNP
rs955875018 704 dbSNP
rs987554263 710 dbSNP
rs888012896 724 dbSNP
rs1006303776 725 dbSNP
rs757014887 726 dbSNP
rs1417006143 730 dbSNP
rs752418310 732 dbSNP
rs997261449 735 dbSNP
rs1345860466 742 dbSNP
rs528093346 743 dbSNP
rs186347977 745 dbSNP
rs943382544 745 dbSNP
rs1030021292 746 dbSNP
rs191302571 756 dbSNP
rs1437268384 759 dbSNP
rs1282517781 761 dbSNP
rs956097432 763 dbSNP
rs1355335647 768 dbSNP
rs1131732 773 dbSNP
rs1228072545 782 dbSNP
rs988636774 783 dbSNP
rs182930430 789 dbSNP
rs1234481515 790 dbSNP
rs968629344 792 dbSNP
rs980006496 793 dbSNP
rs975110701 797 dbSNP
rs1131733 801 dbSNP
rs1231854046 802 dbSNP
rs1131734 805 dbSNP
rs926649133 809 dbSNP
rs1221651897 810 dbSNP
rs1204182305 818 dbSNP
rs1247987297 834 dbSNP
rs571809857 837 dbSNP
rs1340925442 840 dbSNP
rs1047987755 841 dbSNP
rs908033572 848 dbSNP
rs1056590643 849 dbSNP
rs1412973810 850 dbSNP
rs1166974178 853 dbSNP
rs1405924960 853 dbSNP
rs1256235831 857 dbSNP
rs939553023 858 dbSNP
rs917977773 863 dbSNP
rs1352580796 866 dbSNP
rs1413305467 869 dbSNP
rs929483952 875 dbSNP
rs1380483867 877 dbSNP
rs1230575080 879 dbSNP
rs1047853408 911 dbSNP
rs895593317 912 dbSNP
rs888034904 913 dbSNP
rs1274839781 923 dbSNP
rs1012668223 930 dbSNP
rs1044417547 932 dbSNP
rs904201833 934 dbSNP
rs1158939003 937 dbSNP
rs1473019241 940 dbSNP
rs1006508876 942 dbSNP
rs1183490009 943 dbSNP
rs1000090415 944 dbSNP
rs1039260859 955 dbSNP
rs1169368766 963 dbSNP
rs150710022 968 dbSNP
rs1009186677 973 dbSNP
rs550865068 977 dbSNP
rs1333894318 979 dbSNP
rs567824248 985 dbSNP
rs1450672767 988 dbSNP
rs1268865840 993 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000373842.4 | 3UTR | AGAUGACGCCAUUGCACUCCAGCCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
69 hsa-miR-6511b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059269 CELF1 CUGBP Elav-like family member 1 2 2
MIRT061287 IPO7 importin 7 2 2
MIRT115533 MAZ MYC associated zinc finger protein 2 2
MIRT345986 BIRC5 baculoviral IAP repeat containing 5 2 8
MIRT379536 HNRNPK heterogeneous nuclear ribonucleoprotein K 2 2
MIRT442491 RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit 2 8
MIRT443701 HUNK hormonally up-regulated Neu-associated kinase 2 4
MIRT459167 HSPA6 heat shock protein family A (Hsp70) member 6 2 21
MIRT497179 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT497846 GATA6 GATA binding protein 6 2 4
MIRT519625 ZNF781 zinc finger protein 781 2 2
MIRT519838 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT528560 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT530718 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT530810 GPR182 G protein-coupled receptor 182 2 2
MIRT533265 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT533726 TMEM246 transmembrane protein 246 2 2
MIRT535547 P2RY2 purinergic receptor P2Y2 2 2
MIRT536019 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT539494 ACTN4 actinin alpha 4 2 2
MIRT541793 MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2 8
MIRT554509 RUNX1T1 RUNX1 translocation partner 1 2 2
MIRT558784 CEP55 centrosomal protein 55 2 2
MIRT560013 ZNF525 zinc finger protein 525 2 2
MIRT560078 ZNF195 zinc finger protein 195 2 2
MIRT570135 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT570890 ZNF780A zinc finger protein 780A 2 2
MIRT607972 SNX22 sorting nexin 22 2 2
MIRT608104 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT610471 ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 2 4
MIRT611134 GGT7 gamma-glutamyltransferase 7 2 2
MIRT611448 NRIP3 nuclear receptor interacting protein 3 2 2
MIRT613019 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT615753 C6 complement C6 2 2
MIRT620464 CERS6 ceramide synthase 6 2 2
MIRT632248 VPS41 VPS41, HOPS complex subunit 2 2
MIRT636099 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT637452 ZNF324B zinc finger protein 324B 2 2
MIRT638927 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT646768 WDR3 WD repeat domain 3 2 2
MIRT652610 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT652868 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT653655 SLC27A4 solute carrier family 27 member 4 2 2
MIRT657089 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657884 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT662919 MED18 mediator complex subunit 18 2 2
MIRT685622 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT687427 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT692304 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT695127 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695144 PRY PTPN13-like, Y-linked 2 2
MIRT696286 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT699350 SLC35E1 solute carrier family 35 member E1 2 2
MIRT709901 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT710877 SLC25A42 solute carrier family 25 member 42 2 2
MIRT711365 MED7 mediator complex subunit 7 2 2
MIRT711444 FRMPD3 FERM and PDZ domain containing 3 2 2
MIRT713221 RCAN2 regulator of calcineurin 2 2 2
MIRT713281 LAIR1 leukocyte associated immunoglobulin like receptor 1 2 2
MIRT714195 TRAF7 TNF receptor associated factor 7 2 2
MIRT715152 IL12B interleukin 12B 2 2
MIRT719197 CASP10 caspase 10 2 2
MIRT719469 SRF serum response factor 2 2
MIRT720197 MPP6 membrane palmitoylated protein 6 2 2
MIRT720449 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720461 RAB31 RAB31, member RAS oncogene family 2 2
MIRT721646 ZNF207 zinc finger protein 207 2 2
MIRT722001 CLLU1OS chronic lymphocytic leukemia up-regulated 1 opposite strand 2 2
MIRT725521 FAM229B family with sequence similarity 229 member B 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6511b-3p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia tissue
hsa-miR-6511b-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-6511b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-6511b-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6511b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6511b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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