pre-miRNA Information
pre-miRNA hsa-mir-6752   
Genomic Coordinates chr11: 67490245 - 67490315
Description Homo sapiens miR-6752 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6752-3p
Sequence 51| UCCCUGCCCCCAUACUCCCAG |71
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760443460 2 dbSNP
rs746450218 4 dbSNP
rs897972135 4 dbSNP
rs766020814 10 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FBXO2   
Synonyms FBG1, FBX2, Fbs1, NFB42, OCP1
Description F-box protein 2
Transcript NM_012168   
Expression
Putative miRNA Targets on FBXO2
3'UTR of FBXO2
(miRNA target sites are highlighted)
>FBXO2|NM_012168|3'UTR
   1 GCGACCCTGCCTCCACTCTCCCCCAGCTGCCTGGAGGGGCAAAGGTCGAGGGTAGATAGGCCTTAACTTAGTCCATAGCG
  81 TCCTCACCTTCCCCAAGCCACACATCCTCCTCCCATCCCTTGCTCCGATCCCAGCCCCTGAGCAGGGAGAGAGAAGTTTT
 161 GTTGGCATAGGTTTGCTTAGGTAGCCGGCTTCTAGAATGTAGATCCGTGAGGGCGTGAGCTTGGACTGGACCCACTGCTG
 241 ATTCCCTGCACCTAGCACAGTGCTTGCCACAAAGTGGGCTCTCAATAAATATTATTTGTCCAAGGAAGGAATGAATGAAA
 321 AAATGGATAAACAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gacccucauaccccCGUCCCu 5'
                        |||||| 
Target 5' atcccagcccctgaGCAGGGa 3'
128 - 148 120.00 -11.90
2
miRNA  3' gaCCCUCAUACC----CCCGUCccu 5'
            |||:  | ||    |||:||   
Target 5' gaGGGGCAAAGGTCGAGGGTAGata 3'
34 - 58 97.00 -14.12
3
miRNA  3' gacCCUC-AUACCCCCG--UCCcu 5'
             | || | ||  |||  |||  
Target 5' agaGAAGTTTTGTTGGCATAGGtt 3'
150 - 173 90.00 -6.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26976175 15 COSMIC
COSN31544077 26 COSMIC
COSN30186688 55 COSMIC
COSN30491227 55 COSMIC
COSN30177729 58 COSMIC
COSN30150658 82 COSMIC
COSN30130416 97 COSMIC
COSN30531200 207 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs775127494 2 dbSNP
rs181587119 4 dbSNP
rs776503750 5 dbSNP
rs371569494 6 dbSNP
rs773349330 14 dbSNP
rs1055547 15 dbSNP
rs778955384 21 dbSNP
rs1254713199 22 dbSNP
rs1209726783 23 dbSNP
rs1483141439 25 dbSNP
rs375524213 26 dbSNP
rs749699103 30 dbSNP
rs1339105518 34 dbSNP
rs888586565 37 dbSNP
rs780488674 38 dbSNP
rs1439926028 39 dbSNP
rs758020366 40 dbSNP
rs1353657402 44 dbSNP
rs1292674634 45 dbSNP
rs563523547 47 dbSNP
rs775867348 52 dbSNP
rs959497374 58 dbSNP
rs1336079925 65 dbSNP
rs1295247042 66 dbSNP
rs75179987 73 dbSNP
rs974271454 76 dbSNP
rs901413391 80 dbSNP
rs1327910629 81 dbSNP
rs575076225 106 dbSNP
rs867954355 108 dbSNP
rs1162241982 112 dbSNP
rs1041087310 116 dbSNP
rs1460477151 121 dbSNP
rs1411970772 124 dbSNP
rs1178609895 126 dbSNP
rs1468240409 143 dbSNP
rs748771891 156 dbSNP
rs1483406787 157 dbSNP
rs1181502198 167 dbSNP
rs1469361397 169 dbSNP
rs886665444 171 dbSNP
rs942693130 185 dbSNP
rs1284983954 186 dbSNP
rs889881238 187 dbSNP
rs997680250 192 dbSNP
rs1371412332 196 dbSNP
rs1043503767 199 dbSNP
rs1278806454 201 dbSNP
rs777442572 206 dbSNP
rs1372832306 207 dbSNP
rs769615021 210 dbSNP
rs1323810494 212 dbSNP
rs115007707 214 dbSNP
rs1266267671 224 dbSNP
rs1388762424 228 dbSNP
rs1160627550 234 dbSNP
rs936718826 240 dbSNP
rs1406790202 244 dbSNP
rs1158415492 251 dbSNP
rs1454994063 256 dbSNP
rs1255215285 262 dbSNP
rs903954795 268 dbSNP
rs915055136 276 dbSNP
rs1042346621 294 dbSNP
rs987919765 305 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gacccucauaccccCGUCCCu 5'
                        |||||| 
Target 5' -------------aGCAGGGa 3'
1 - 8
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000354287.4 | 3UTR | AGCAGGGAGAGAGAAGUUUUGUUGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
110 hsa-miR-6752-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT152341 TNFSF9 TNF superfamily member 9 2 2
MIRT273594 SP1 Sp1 transcription factor 2 2
MIRT291927 TPM4 tropomyosin 4 2 4
MIRT311186 ANKRD33B ankyrin repeat domain 33B 2 4
MIRT378521 CDKN1A cyclin dependent kinase inhibitor 1A 2 4
MIRT452467 SORCS2 sortilin related VPS10 domain containing receptor 2 2 2
MIRT478636 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT496343 TMEM81 transmembrane protein 81 2 2
MIRT496646 MFAP3 microfibril associated protein 3 2 2
MIRT496711 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT499242 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT519777 ZNF354B zinc finger protein 354B 2 6
MIRT520883 STX17 syntaxin 17 2 2
MIRT522476 ZAK mitogen-activated protein kinase kinase kinase 20 2 2
MIRT523587 G3BP2 G3BP stress granule assembly factor 2 2 6
MIRT525240 KCNJ12 potassium voltage-gated channel subfamily J member 12 2 2
MIRT527025 PABPN1L poly(A) binding protein nuclear 1 like, cytoplasmic 2 2
MIRT527709 IL17REL interleukin 17 receptor E like 2 2
MIRT530778 GPD1 glycerol-3-phosphate dehydrogenase 1 2 2
MIRT531883 SCN1B sodium voltage-gated channel beta subunit 1 2 2
MIRT533043 ZBTB46 zinc finger and BTB domain containing 46 2 2
MIRT535062 PPP2R5D protein phosphatase 2 regulatory subunit B'delta 2 4
MIRT536512 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT543793 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 2 2
MIRT563977 HCFC1 host cell factor C1 2 2
MIRT569472 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT570600 NFIX nuclear factor I X 2 2
MIRT571402 MED4 mediator complex subunit 4 2 2
MIRT608418 PPIC peptidylprolyl isomerase C 2 6
MIRT608928 REXO2 RNA exonuclease 2 2 4
MIRT609357 ZNF664 zinc finger protein 664 2 2
MIRT611189 WBSCR17 polypeptide N-acetylgalactosaminyltransferase 17 2 4
MIRT615266 DPF2 double PHD fingers 2 2 2
MIRT615408 VDAC2 voltage dependent anion channel 2 2 2
MIRT616323 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT616566 ZNF512B zinc finger protein 512B 2 2
MIRT616745 TAZ tafazzin 2 2
MIRT617316 MBOAT1 membrane bound O-acyltransferase domain containing 1 2 2
MIRT620030 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT621166 RTTN rotatin 2 2
MIRT623501 KCNQ3 potassium voltage-gated channel subfamily Q member 3 2 2
MIRT623524 KCNK10 potassium two pore domain channel subfamily K member 10 2 2
MIRT629683 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT630795 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT634638 HIP1 huntingtin interacting protein 1 2 4
MIRT636788 RAB40B RAB40B, member RAS oncogene family 2 2
MIRT640332 DAAM2 dishevelled associated activator of morphogenesis 2 2 2
MIRT640557 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT643319 TMEM151B transmembrane protein 151B 2 2
MIRT643991 DUSP28 dual specificity phosphatase 28 2 2
MIRT644618 CD300E CD300e molecule 2 2
MIRT646445 XRCC2 X-ray repair cross complementing 2 2 2
MIRT648020 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT648077 ZMIZ2 zinc finger MIZ-type containing 2 2 2
MIRT649618 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650414 ZNF442 zinc finger protein 442 2 2
MIRT650850 SEMA4G semaphorin 4G 2 2
MIRT654694 PSMB5 proteasome subunit beta 5 2 2
MIRT655512 PAIP2B poly(A) binding protein interacting protein 2B 2 2
MIRT657620 GRAP2 GRB2-related adaptor protein 2 2 2
MIRT658009 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT658329 FAM83F family with sequence similarity 83 member F 2 2
MIRT658832 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658920 DPY19L4 dpy-19 like 4 2 2
MIRT661058 RPL18A ribosomal protein L18a 2 2
MIRT662342 MYLK3 myosin light chain kinase 3 2 2
MIRT663451 FBXO2 F-box protein 2 2 2
MIRT676752 SGTB small glutamine rich tetratricopeptide repeat containing beta 2 4
MIRT684705 LRRD1 leucine rich repeats and death domain containing 1 2 2
MIRT687247 PDHB pyruvate dehydrogenase E1 beta subunit 2 2
MIRT693881 NT5C2 5'-nucleotidase, cytosolic II 2 2
MIRT693922 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT695921 ZNF174 zinc finger protein 174 2 2
MIRT702867 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT708863 TMSB4X thymosin beta 4, X-linked 2 2
MIRT708936 CRY2 cryptochrome circadian clock 2 2 2
MIRT709476 FAXC failed axon connections homolog 2 2
MIRT709752 UBD ubiquitin D 2 2
MIRT710128 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT710274 FAM107A family with sequence similarity 107 member A 2 2
MIRT711146 TMEM174 transmembrane protein 174 2 2
MIRT712582 ATP2B4 ATPase plasma membrane Ca2+ transporting 4 2 2
MIRT712648 TXNL4A thioredoxin like 4A 2 2
MIRT713325 TMEM44 transmembrane protein 44 2 2
MIRT713413 PEX16 peroxisomal biogenesis factor 16 2 2
MIRT713891 RNF19B ring finger protein 19B 2 2
MIRT714549 COL14A1 collagen type XIV alpha 1 chain 2 2
MIRT714809 ARHGEF19 Rho guanine nucleotide exchange factor 19 2 2
MIRT714840 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT715779 DDX42 DEAD-box helicase 42 2 2
MIRT715795 TBL3 transducin beta like 3 2 2
MIRT716088 RNF150 ring finger protein 150 2 2
MIRT716712 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT716737 APOL6 apolipoprotein L6 2 2
MIRT717069 MTMR6 myotubularin related protein 6 2 2
MIRT718185 HLCS holocarboxylase synthetase 2 2
MIRT719386 SECTM1 secreted and transmembrane 1 2 2
MIRT720679 SLC39A13 solute carrier family 39 member 13 2 2
MIRT721315 FAM58A cyclin Q 2 2
MIRT721396 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT721896 ITPR2 inositol 1,4,5-trisphosphate receptor type 2 2 2
MIRT722442 ZBTB7B zinc finger and BTB domain containing 7B 2 2
MIRT723009 FADS1 fatty acid desaturase 1 2 2
MIRT723675 CTC1 CST telomere replication complex component 1 2 2
MIRT723774 ROBO4 roundabout guidance receptor 4 2 2
MIRT723814 OR1L8 olfactory receptor family 1 subfamily L member 8 2 2
MIRT723959 TMEM184A transmembrane protein 184A 2 2
MIRT724449 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT724798 C1D C1D nuclear receptor corepressor 2 2
MIRT725626 CAMKV CaM kinase like vesicle associated 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6752-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-6752-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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