pre-miRNA Information
pre-miRNA hsa-mir-1245a   
Genomic Coordinates chr2: 188978092 - 188978161
Description Homo sapiens miR-1245a stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1245a
Sequence 45| AAGUGAUCUAAAGGCCUACAU |65
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31562560 15 COSMIC
COSN26581044 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs906938680 2 dbSNP
rs1159117523 3 dbSNP
rs780486044 6 dbSNP
rs771479866 17 dbSNP
rs1002976932 18 dbSNP
rs1428029219 19 dbSNP
Putative Targets

Gene Information
Gene Symbol CCR6   
Synonyms BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22
Description C-C motif chemokine receptor 6
Transcript NM_004367   
Other Transcripts NM_031409   
Expression
Putative miRNA Targets on CCR6
3'UTR of CCR6
(miRNA target sites are highlighted)
>CCR6|NM_004367|3'UTR
   1 TAGAAAGCTGAGTCTCCCTAAGGCATGTGTGAAACATACTCATAGATGTTATGCAAAAAAAAGTCTATGGCCAGGTATGC
  81 ATGGAAAATGTGGGAATTAAGCAAAATCAAGCAAGCCTCTCTCCTGCGGGACTTAACGTGCTCATGGGCTGTGTGATCTC
 161 TTCAGGGTGGGGTGGTCTCTGATAGGTAGCATTTTCCAGCACTTTGCAAGGAATGTTTTGTAGCTCTAGGGTATATATCC
 241 GCCTGGCATTTCACAAAACAGCCTTTGGGAAATGCTGAATTAAAGTGAATTGTTGACAAATGTAAACATTTTCAGAAATA
 321 TTCATGAAGCGGTCACAGATCACAGTGTCTTTTGGTTACAGCACAAAATGATGGCAGTGGTTTGAAAAACTAAAACAGAA
 401 AAAAAAATGGAAGCCAACACATCACTCATTTTAGGCAAATGTTTAAACATTTTTATCTATCAGAATGTTTATTGTTGCTG
 481 GTTATAAGCAGCAGGATTGGCCGGCTAGTGTTTCCTCTCATTTCCCTTTGATACAGTCAACAAGCCTGACCCTGTAAAAT
 561 GGAGGTGGAAAGACAAGCTCAAGTGTTCACAACCTGGAAGTGCTTCGGGAAGAAGGGGACAATGGCAGAACAGGTGTTGG
 641 TGACAATTGTCACCAATTGGATAAAGCAGCTCAGGTTGTAGTGGGCCATTAGGAAACTGTCGGTTTGCTTTGATTTCCCT
 721 GGGAGCTGTTCTCTGTCGTGAGTGTCTCTTGTCTAAACGTCCATTAAGCTGAGAGTGCTATGAAGACAGGATCTAGAATA
 801 ATCTTGCTCACAGCTGTGCTCTGAGTGCCTAGCGGAGTTCCAGCAAACAAAATGGACTCAAGAGAGATTTGATTAATGAA
 881 TCGTAATGAAGTTGGGGTTTATTGTACAGTTTAAAATGTTAGATGTTTTTAATTTTTTAAATAAATGGAATACTTTTTTT
 961 TTTTTTTTAAAGAAAGCAACTTTACTGAGACAATGTAGAAAGAAGTTTTGTTCCGTTTCTTTAATGTGGTTGAAGAGCAA
1041 TGTGTGGCTGAAGACTTTTGTTATGAGGAGCTGCAGATTAGCTAGGGGACAGCTGGAATTATGCTGGCTTCTGATAATTA
1121 TTTTAAAGGGGTCTGAAATTTGTGATGGAATCAGATTTTAACAGCTCTCTTCAATGACATAGAAAGTTCATGGAACTCAT
1201 GTTTTTAAAGGGCTATGTAAATATATGAACATTAGAAAAATAGCAACTTGTGTTACAAAAATACAAACACATGTTAGGAA
1281 GGTACTGTCATGGGCTAGGCATGGTGGCTCACACCTGTAATCCCAGCATTTTGGGAAGCTAAGATGGGTGGATCACTTGA
1361 GGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCGAAACCCCTCTCTACTAAAAATACAAAAATTTGCCAGGCGTGGTG
1441 GCGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAAGAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAG
1521 CCGAGATCGTGCCATTGCACTCCAGCCTGGGTGACAAAGCGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAGGAAAG
1601 AACTGTCATGTAAACATACCAACATGTTTAAACCTGACAATGGTGTTATTTGAAACTTTATATTGTTCTTGTAAGCTTTA
1681 ACTATATCTCTCTTTAAAATGCAAAATAATGTCTTAAGATTCAAAGTCTGTATTTTTAAAGCATGGCTTTGGCTTTGCAA
1761 AATAAAAAATGTGTTTTGTACATGAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uacAUCCGGAAAUCUAGUGAa 5'
             |:||    |:||||||| 
Target 5' agaTGGG----TGGATCACTt 3'
1342 - 1358 148.00 -12.90
2
miRNA  3' uacauCCGGAAAUCUAGUGaa 5'
               ||:|   |||||||  
Target 5' gaagcGGTC-ACAGATCACag 3'
326 - 345 127.00 -11.00
3
miRNA  3' uacAUCCGGAAAUCUAGUGAa 5'
             |:|||: |  |||| || 
Target 5' tcaTGGGCTGTGTGATCTCTt 3'
142 - 162 126.00 -12.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30463414 19 COSMIC
COSN30452677 21 COSMIC
COSN30462223 32 COSMIC
COSN15664116 63 COSMIC
COSN30140994 72 COSMIC
COSN31549921 75 COSMIC
COSN30156180 76 COSMIC
COSN31494034 81 COSMIC
COSN31555486 89 COSMIC
COSN8513707 102 COSMIC
COSN32077960 139 COSMIC
COSN28790900 141 COSMIC
COSN28148888 180 COSMIC
COSN29358320 226 COSMIC
COSN32062645 589 COSMIC
COSN32064221 804 COSMIC
COSN20103645 968 COSMIC
COSN20103643 969 COSMIC
COSN26403079 1444 COSMIC
COSN9501825 1515 COSMIC
COSN2153321 1760 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1405277610 1 dbSNP
rs757970953 2 dbSNP
rs149010509 3 dbSNP
rs367637187 8 dbSNP
rs371334790 9 dbSNP
rs774136024 15 dbSNP
rs375979417 27 dbSNP
rs368305564 28 dbSNP
rs1236105990 40 dbSNP
rs1472732336 42 dbSNP
rs750367865 44 dbSNP
rs777781807 46 dbSNP
rs1382748999 47 dbSNP
rs1437891185 49 dbSNP
rs373043902 53 dbSNP
rs533011104 54 dbSNP
rs1181327619 55 dbSNP
rs1486256107 55 dbSNP
rs551258713 56 dbSNP
rs1207007536 57 dbSNP
rs950059260 59 dbSNP
rs933190177 61 dbSNP
rs1047555947 68 dbSNP
rs1234984057 69 dbSNP
rs1319841141 72 dbSNP
rs55838414 79 dbSNP
rs886381225 83 dbSNP
rs1311984652 87 dbSNP
rs1214616804 90 dbSNP
rs958228368 99 dbSNP
rs1363404465 102 dbSNP
rs200469053 103 dbSNP
rs1006105474 106 dbSNP
rs927351962 107 dbSNP
rs988260098 113 dbSNP
rs191972938 120 dbSNP
rs1017365981 128 dbSNP
rs1459810674 129 dbSNP
rs1367200921 131 dbSNP
rs777260856 138 dbSNP
rs566693748 139 dbSNP
rs1392040975 142 dbSNP
rs1186764480 145 dbSNP
rs886270348 146 dbSNP
rs1253934682 158 dbSNP
rs1023089234 164 dbSNP
rs1004833485 168 dbSNP
rs971468356 171 dbSNP
rs1040658378 172 dbSNP
rs1294759257 177 dbSNP
rs533971801 179 dbSNP
rs1371248928 184 dbSNP
rs1305225898 185 dbSNP
rs1031826754 188 dbSNP
rs1384744324 197 dbSNP
rs35695660 210 dbSNP
rs746856512 211 dbSNP
rs1305495272 212 dbSNP
rs990395012 218 dbSNP
rs548930998 226 dbSNP
rs1462888142 227 dbSNP
rs1166786210 231 dbSNP
rs1373023470 231 dbSNP
rs943006046 232 dbSNP
rs996219402 235 dbSNP
rs770791820 236 dbSNP
rs1395887937 240 dbSNP
rs1201230009 241 dbSNP
rs41411246 242 dbSNP
rs1266324710 249 dbSNP
rs1196227404 253 dbSNP
rs1483987328 258 dbSNP
rs923065966 262 dbSNP
rs368123608 263 dbSNP
rs139105246 277 dbSNP
rs41501544 278 dbSNP
rs886247876 296 dbSNP
rs879232056 301 dbSNP
rs1033219608 310 dbSNP
rs143957696 325 dbSNP
rs1330156465 331 dbSNP
rs941943040 332 dbSNP
rs538687486 336 dbSNP
rs554440150 337 dbSNP
rs1352849622 341 dbSNP
rs1306762229 350 dbSNP
rs1429708390 379 dbSNP
rs956396296 383 dbSNP
rs572685704 394 dbSNP
rs1376096673 396 dbSNP
rs1174404319 397 dbSNP
rs1292445933 397 dbSNP
rs1464726958 399 dbSNP
rs199864702 399 dbSNP
rs554563917 408 dbSNP
rs6931699 409 dbSNP
rs1248508508 412 dbSNP
rs753426256 418 dbSNP
rs1182817008 420 dbSNP
rs188648743 421 dbSNP
rs927278473 422 dbSNP
rs930767595 425 dbSNP
rs543513205 429 dbSNP
rs1261002999 430 dbSNP
rs1229360774 431 dbSNP
rs1331619809 437 dbSNP
rs1286872952 440 dbSNP
rs1165810591 456 dbSNP
rs1341658750 458 dbSNP
rs745643756 460 dbSNP
rs1386460773 463 dbSNP
rs1429638142 466 dbSNP
rs1401729729 472 dbSNP
rs1165719318 475 dbSNP
rs1049124852 481 dbSNP
rs1032275659 485 dbSNP
rs956195223 495 dbSNP
rs1158151975 498 dbSNP
rs1475493732 499 dbSNP
rs1239200492 502 dbSNP
rs1012252013 503 dbSNP
rs17860854 504 dbSNP
rs1380067308 515 dbSNP
rs74592470 516 dbSNP
rs1441383195 519 dbSNP
rs1261857312 520 dbSNP
rs1454423575 525 dbSNP
rs940478403 527 dbSNP
rs1040308726 535 dbSNP
rs1266556340 542 dbSNP
rs532363199 542 dbSNP
rs1315439793 548 dbSNP
rs1357641844 554 dbSNP
rs901730232 566 dbSNP
rs1176553172 569 dbSNP
rs1364459319 574 dbSNP
rs1226072568 585 dbSNP
rs1243293209 594 dbSNP
rs1339892555 602 dbSNP
rs1321313783 604 dbSNP
rs541101238 607 dbSNP
rs1050113782 608 dbSNP
rs3093006 610 dbSNP
rs1415836105 621 dbSNP
rs527610365 622 dbSNP
rs1000651818 632 dbSNP
rs1196415856 650 dbSNP
rs748033664 652 dbSNP
rs1189949566 654 dbSNP
rs41409048 658 dbSNP
rs954631725 660 dbSNP
rs891967008 667 dbSNP
rs180999088 670 dbSNP
rs1452507087 671 dbSNP
rs907707530 676 dbSNP
rs528577100 682 dbSNP
rs1037536754 683 dbSNP
rs1449451597 686 dbSNP
rs980318764 693 dbSNP
rs1230781685 702 dbSNP
rs1363262478 703 dbSNP
rs774950476 707 dbSNP
rs1297194707 710 dbSNP
rs1191676352 717 dbSNP
rs1375214183 727 dbSNP
rs1462077320 738 dbSNP
rs916524706 738 dbSNP
rs549900554 739 dbSNP
rs547158812 747 dbSNP
rs41331945 748 dbSNP
rs1169911539 749 dbSNP
rs965603541 752 dbSNP
rs41376751 759 dbSNP
rs1193819766 778 dbSNP
rs1364213981 781 dbSNP
rs1380246432 790 dbSNP
rs1297676901 792 dbSNP
rs1451523096 806 dbSNP
rs189354587 808 dbSNP
rs536560287 819 dbSNP
rs3093005 831 dbSNP
rs1011788376 833 dbSNP
rs746764726 834 dbSNP
rs1272857199 835 dbSNP
rs1435557615 838 dbSNP
rs1350996215 843 dbSNP
rs140165498 853 dbSNP
rs1263926771 858 dbSNP
rs543650060 867 dbSNP
rs558610397 868 dbSNP
rs1203712652 872 dbSNP
rs1029954142 882 dbSNP
rs182173696 883 dbSNP
rs1050328108 884 dbSNP
rs1429600667 891 dbSNP
rs187212069 893 dbSNP
rs1426579946 894 dbSNP
rs1477929416 897 dbSNP
rs936284311 897 dbSNP
rs1481101386 898 dbSNP
rs1184906263 903 dbSNP
rs907654975 904 dbSNP
rs76436762 905 dbSNP
rs1210998079 913 dbSNP
rs1314153373 931 dbSNP
rs1276821208 933 dbSNP
rs1218891902 935 dbSNP
rs1329536530 936 dbSNP
rs559501180 945 dbSNP
rs41322047 947 dbSNP
rs1349867005 950 dbSNP
rs973261402 950 dbSNP
rs1413088186 954 dbSNP
rs1457463949 954 dbSNP
rs35220458 954 dbSNP
rs369925665 954 dbSNP
rs536636155 954 dbSNP
rs58535245 954 dbSNP
rs67363454 954 dbSNP
rs764558623 954 dbSNP
rs79569135 954 dbSNP
rs55796656 964 dbSNP
rs916389725 965 dbSNP
rs1451390184 969 dbSNP
rs1471895829 969 dbSNP
rs370035138 970 dbSNP
rs947970783 996 dbSNP
rs1013317184 1000 dbSNP
rs1484252205 1010 dbSNP
rs1386136055 1014 dbSNP
rs1046307596 1015 dbSNP
rs907360677 1016 dbSNP
rs569983083 1024 dbSNP
rs928635736 1036 dbSNP
rs1225353097 1038 dbSNP
rs1284196166 1051 dbSNP
rs938732197 1071 dbSNP
rs1313403398 1072 dbSNP
rs1229989828 1103 dbSNP
rs1220844604 1109 dbSNP
rs1301768767 1115 dbSNP
rs1435287098 1122 dbSNP
rs1390472440 1126 dbSNP
rs1237393048 1132 dbSNP
rs1053528438 1136 dbSNP
rs1322958624 1139 dbSNP
rs1262863766 1154 dbSNP
rs891917210 1168 dbSNP
rs947464261 1169 dbSNP
rs1486514265 1177 dbSNP
rs1166040882 1178 dbSNP
rs1209787247 1179 dbSNP
rs1043211717 1180 dbSNP
rs10946217 1185 dbSNP
rs1490706608 1186 dbSNP
rs1411629186 1197 dbSNP
rs1183138028 1211 dbSNP
rs757987475 1217 dbSNP
rs1199447931 1219 dbSNP
rs1410835064 1225 dbSNP
rs952063798 1226 dbSNP
rs1030571222 1236 dbSNP
rs763472427 1244 dbSNP
rs1004593094 1251 dbSNP
rs1223599967 1253 dbSNP
rs1319858943 1256 dbSNP
rs1311388565 1257 dbSNP
rs1228579116 1264 dbSNP
rs1014914817 1270 dbSNP
rs11575083 1271 dbSNP
rs1433929963 1271 dbSNP
rs116855733 1279 dbSNP
rs1294490994 1292 dbSNP
rs973110352 1308 dbSNP
rs531527941 1311 dbSNP
rs969181838 1316 dbSNP
rs986048423 1318 dbSNP
rs1430528630 1341 dbSNP
rs925168696 1344 dbSNP
rs550036935 1346 dbSNP
rs11575084 1350 dbSNP
rs1267707590 1351 dbSNP
rs191584399 1363 dbSNP
rs1487459613 1365 dbSNP
rs1291011774 1367 dbSNP
rs1205218374 1368 dbSNP
rs1343614357 1387 dbSNP
rs1271872880 1392 dbSNP
rs181542353 1396 dbSNP
rs745720012 1397 dbSNP
rs947494952 1415 dbSNP
rs755844205 1418 dbSNP
rs949191837 1419 dbSNP
rs1388937332 1427 dbSNP
rs780256313 1430 dbSNP
rs932176604 1435 dbSNP
rs768821373 1436 dbSNP
rs1410997695 1441 dbSNP
rs41472245 1443 dbSNP
rs11575085 1444 dbSNP
rs374914584 1446 dbSNP
rs1178588621 1452 dbSNP
rs1250709956 1454 dbSNP
rs1423056293 1458 dbSNP
rs1055983314 1462 dbSNP
rs1483995524 1466 dbSNP
rs1248976534 1479 dbSNP
rs1005511890 1482 dbSNP
rs888056770 1488 dbSNP
rs768799983 1489 dbSNP
rs898802553 1490 dbSNP
rs185625723 1492 dbSNP
rs1257432451 1493 dbSNP
rs1230645405 1500 dbSNP
rs1321798532 1510 dbSNP
rs1387061183 1523 dbSNP
rs994601684 1524 dbSNP
rs1306249775 1527 dbSNP
rs1164362025 1529 dbSNP
rs1304772283 1530 dbSNP
rs1464742309 1535 dbSNP
rs1354027994 1536 dbSNP
rs1428257604 1540 dbSNP
rs1159711152 1544 dbSNP
rs1460474350 1553 dbSNP
rs1409727835 1556 dbSNP
rs9366094 1558 dbSNP
rs1257684994 1560 dbSNP
rs11575086 1561 dbSNP
rs1452431294 1562 dbSNP
rs1157876556 1574 dbSNP
rs1184863114 1574 dbSNP
rs1213942869 1574 dbSNP
rs1278341324 1574 dbSNP
rs1320952688 1574 dbSNP
rs1369625854 1574 dbSNP
rs1386220401 1574 dbSNP
rs1424299578 1574 dbSNP
rs1443618925 1574 dbSNP
rs1458654468 1574 dbSNP
rs1473093800 1574 dbSNP
rs1491434028 1574 dbSNP
rs35977074 1574 dbSNP
rs1015379845 1575 dbSNP
rs962065709 1575 dbSNP
rs1466500554 1576 dbSNP
rs1313333821 1577 dbSNP
rs1282627419 1582 dbSNP
rs1385711815 1586 dbSNP
rs1204988414 1588 dbSNP
rs998019977 1588 dbSNP
rs1247330791 1595 dbSNP
rs1272850833 1596 dbSNP
rs1243929351 1598 dbSNP
rs1305261927 1601 dbSNP
rs1205959518 1603 dbSNP
rs1030377682 1609 dbSNP
rs1298554595 1610 dbSNP
rs1251549494 1619 dbSNP
rs534815245 1621 dbSNP
rs6456162 1622 dbSNP
rs1181566159 1625 dbSNP
rs1244734980 1639 dbSNP
rs981979868 1643 dbSNP
rs1035255995 1646 dbSNP
rs1240710800 1650 dbSNP
rs1192989038 1651 dbSNP
rs956655935 1653 dbSNP
rs1452668205 1657 dbSNP
rs1292690522 1660 dbSNP
rs1185866761 1661 dbSNP
rs1220941057 1666 dbSNP
rs1417254931 1670 dbSNP
rs1408299528 1672 dbSNP
rs985933487 1675 dbSNP
rs988421526 1676 dbSNP
rs1337771516 1679 dbSNP
rs1269366135 1688 dbSNP
rs1436994338 1691 dbSNP
rs913247856 1694 dbSNP
rs55701277 1703 dbSNP
rs542251187 1708 dbSNP
rs988067551 1710 dbSNP
rs1170009470 1711 dbSNP
rs142353378 1717 dbSNP
rs576436832 1718 dbSNP
rs1469480292 1723 dbSNP
rs761137457 1724 dbSNP
rs766784882 1725 dbSNP
rs1248840797 1731 dbSNP
rs1051945788 1742 dbSNP
rs1046587617 1756 dbSNP
rs1453750109 1764 dbSNP
rs1270161085 1769 dbSNP
rs926344805 1772 dbSNP
rs56240207 1777 dbSNP
rs1055914757 1783 dbSNP
rs1215862095 1786 dbSNP
rs1272616002 1787 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000341935.5 | 3UTR | CUAAGAUGGGUGGAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
UCEC 0.893 0.15 1.000 0.5 3 Click to see details
HNSC 0.414 0.18 0.643 0.06 7 Click to see details
BLCA 0.275 0.41 0.500 0.33 3 Click to see details
BRCA -0.221 0.43 -0.500 0.33 3 Click to see details
BRCA -0.221 0.43 -0.500 0.33 3 Click to see details
BRCA -0.221 0.43 -0.500 0.33 3 Click to see details
BRCA -0.221 0.43 -0.500 0.33 3 Click to see details
BRCA -0.221 0.43 -0.500 0.33 3 Click to see details
109 hsa-miR-1245a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006574 BRCA2 BRCA2, DNA repair associated 2 1
MIRT055432 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT063879 RASSF8 Ras association domain family member 8 2 6
MIRT077025 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT095775 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT099172 MAP3K4 mitogen-activated protein kinase kinase kinase 4 2 2
MIRT175616 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT456518 LYPLAL1 lysophospholipase like 1 2 2
MIRT464457 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465747 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT468257 SFXN4 sideroflexin 4 2 2
MIRT469216 RICTOR RPTOR independent companion of MTOR complex 2 2 2
MIRT472045 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT481795 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT500154 CREBBP CREB binding protein 2 2
MIRT506514 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 4
MIRT506915 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT513901 GRB10 growth factor receptor bound protein 10 2 6
MIRT519128 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT528121 FOXH1 forkhead box H1 2 2
MIRT528942 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT540580 CEP89 centrosomal protein 89 2 2
MIRT545858 ZNF264 zinc finger protein 264 2 4
MIRT547147 PGM3 phosphoglucomutase 3 2 2
MIRT547434 MED4 mediator complex subunit 4 2 2
MIRT554650 ROBO1 roundabout guidance receptor 1 2 2
MIRT558524 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT559762 ABHD5 abhydrolase domain containing 5 2 2
MIRT560438 GOLGA7B golgin A7 family member B 2 2
MIRT561974 LRRC59 leucine rich repeat containing 59 2 2
MIRT562442 DDIT4 DNA damage inducible transcript 4 2 2
MIRT563489 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT568265 BMP2K BMP2 inducible kinase 2 2
MIRT572522 KIAA0232 KIAA0232 2 2
MIRT612801 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT621533 ZNF507 zinc finger protein 507 2 2
MIRT625205 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT625615 ZNF84 zinc finger protein 84 2 2
MIRT629215 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629509 AS3MT arsenite methyltransferase 2 2
MIRT629769 STK25 serine/threonine kinase 25 2 2
MIRT630908 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT632508 RAB13 RAB13, member RAS oncogene family 2 2
MIRT636871 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT637106 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637332 FAM9B family with sequence similarity 9 member B 2 2
MIRT637553 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637639 ZNF431 zinc finger protein 431 2 2
MIRT637836 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT638326 RNF11 ring finger protein 11 2 2
MIRT638393 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT642450 CLUAP1 clusterin associated protein 1 2 2
MIRT642616 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT643133 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644324 NFKBID NFKB inhibitor delta 2 2
MIRT645150 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT645673 ADK adenosine kinase 2 2
MIRT646091 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646858 SLC35E4 solute carrier family 35 member E4 2 2
MIRT650153 ZNF426 zinc finger protein 426 2 2
MIRT652483 TMEM181 transmembrane protein 181 2 2
MIRT653790 SIRPA signal regulatory protein alpha 2 2
MIRT655526 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT657077 JPH2 junctophilin 2 2 2
MIRT657322 HOOK3 hook microtubule tethering protein 3 2 2
MIRT662036 FUT2 fucosyltransferase 2 2 2
MIRT662322 ADM2 adrenomedullin 2 2 2
MIRT663211 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663559 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663937 ZNF554 zinc finger protein 554 2 2
MIRT664689 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT664709 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT665291 ZFP14 ZFP14 zinc finger protein 2 2
MIRT665572 TXNL1 thioredoxin like 1 2 2
MIRT667068 PAOX polyamine oxidase 2 2
MIRT667304 MYO5A myosin VA 2 2
MIRT667442 METTL14 methyltransferase like 14 2 2
MIRT668048 GTPBP10 GTP binding protein 10 2 2
MIRT669604 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT671088 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT674361 SLC35E3 solute carrier family 35 member E3 2 2
MIRT674962 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT676394 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676819 AGMAT agmatinase 2 2
MIRT676891 ENSA endosulfine alpha 2 2
MIRT677059 ZNF34 zinc finger protein 34 2 2
MIRT678424 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678735 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT678930 XPOT exportin for tRNA 2 2
MIRT678954 MYADM myeloid associated differentiation marker 2 2
MIRT679228 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679765 TLR6 toll like receptor 6 2 2
MIRT681992 HRH4 histamine receptor H4 2 2
MIRT687405 NSUN4 NOP2/Sun RNA methyltransferase family member 4 2 2
MIRT694570 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT698449 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT706406 HAS2 hyaluronan synthase 2 2 2
MIRT706582 ZNF432 zinc finger protein 432 2 2
MIRT706838 VHLL VHL like 2 2
MIRT706909 DVL3 dishevelled segment polarity protein 3 2 2
MIRT707052 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT708583 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT708988 CABP4 calcium binding protein 4 2 2
MIRT713041 ADRA2B adrenoceptor alpha 2B 2 2
MIRT713731 SUCO SUN domain containing ossification factor 2 2
MIRT714968 RAB21 RAB21, member RAS oncogene family 2 2
MIRT717485 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT722826 KLK2 kallikrein related peptidase 2 2 2
MIRT723305 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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