pre-miRNA Information
pre-miRNA hsa-mir-124-1   
Genomic Coordinates chr8: 9903388 - 9903472
Description Homo sapiens miR-124-1 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-2   
Genomic Coordinates chr8: 64379149 - 64379257
Description Homo sapiens miR-124-2 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-3   
Genomic Coordinates chr20: 63178500 - 63178586
Description Homo sapiens miR-124-3 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-124-5p
Sequence 14| CGUGUUCACAGCGGACCUUGAU |35
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 8 8 + 64379180 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1280076135 1 dbSNP
rs775858016 4 dbSNP
rs760972715 7 dbSNP
rs1334649236 11 dbSNP
rs1160219511 12 dbSNP
rs764591061 12 dbSNP
rs1261326747 13 dbSNP
rs1344491363 20 dbSNP
rs1340798465 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Increase Plasma Polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Peripheral blood mononuclear cell Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol ASTN2   
Synonyms bA67K19.1
Description astrotactin 2
Transcript NM_001184735   
Other Transcripts NM_001184734 , NM_014010 , NM_198186 , NM_198187 , NM_198188   
Expression
Putative miRNA Targets on ASTN2
3'UTR of ASTN2
(miRNA target sites are highlighted)
>ASTN2|NM_001184735|3'UTR
   1 TTGTGGTGGATAAGCTTTTTGATGTGCTGCTGGATTTGGTTTGCCAATATTTTATTGAAGATTTTTGCATCGATGTTCAT
  81 CAGGGATATTGGTCTAAAATTCTCTTTTTTTGTTGTGTCTCTGCCAGGCTTTGGTATCAGGATGATGTTGGCCTCATAAA
 161 ATGAATTAGGGAGGATTCCCTCTTTTTCTATTGATTTGAATAGTTTCAGAAGGAATGGTACCAGCTCATCTTTGTACCTC
 241 TGGTAGAATTCGGCTGTGAATCCATCTGGTCCTGGACTTATTTTGGTTAGTAGGCTATTAATTATGGCCTCAATTTCAGA
 321 ACCTGTTATTGGTCTATTCAGGGATTCAACTTCTTCCTGGTTTAGTCTTGGGAGGAGGCTGTATGTGTCCAGGAATTTAT
 401 CCATTTCTTCTAGATTTTCTAGTTTATTTGCATAGAGGTGTTTATAGTATTCTCTAATGGTAGTTTGTATTTCTGTGGGA
 481 TCGGTGGTGATATCCCCTTTATCATTTTTTATTGCGTCTATTTGATTCTTCTCTCTTTTATTCTTTATGAGTCTTGCTAG
 561 TAGTCTATCAATTTTGTTGATTTTTTCAAAAAACCAGCTCCTGGATTCATTGATTTTTTGAAGGGTTTTTTTTTTTTTGT
 641 CTCTATCTCCTTCAGTTCTGCTCTCATCTTAGTTATTTCTTGCCTTCTGCTAGCTTTTGTGTGTTTGCTCTTGCTTCTCT
 721 AGTTCTTTTAATTATGATGTTAGGGTGTCAGTTTCAGATCTTTCTTGCTTTCTCCTGTGGGCATTTAGTGCTATAAATCT
 801 CCCTCTACACACTGCTTTAAATGTGTCCCAGAGATTCTGGTATGTTGTGTCCTGTTCTCATTGGTTTCAAAGAACATCTT
 881 TATTTCCGCTTTCATTTCGTTATGTACCCAGTAGTCATTCAGGAGCAAGTTGTTCAGTTTCCATGTAGTTGAGCGGTTTT
 961 GAGTGAGTTTCTTAATCCTGAGTTCTAGTTTGATTGCACTGTGTTCTGAGAGACAGTTTGTTATAATTTCTTTCTTTTAC
1041 ATTTGCTGAGGAGTGCTTTACTTCCCACTGTGTGATCAATTTTGGAATAACTGCGATGTGGTGCTGAGAAGAATGTATAT
1121 TCTGTTGATTGGGGTGGATAGTTCTGTAGATGTCTATTAGGTCCGCTTGGTGCAGAGCTGAGTTCAATTCCTGGATATCC
1201 TTGTTAACTTTCTGTCTCATTGATCTATCTAATGTTGACAGTGGGGTGTTAAAGTCTCCCATTATTATTGTGTGGGAGTC
1281 TAAGTCTCTTTGTAAGTCTCTAAGGACTTGCTTTATGAATCTGGGTGCTCCTATATTGGGTGCATATATATTTAGGATAG
1361 TTAGCTCGAAGAAGGTATCTTCTATTTCTAGTCTGCTGCAAAGGCTCTGTTTTGTTTCCATTGGAAACAGATGTTGAATT
1441 TTCTGTGTCTATTAAAATGATTGTATAGTTTATCTCTCTAAATTTGTTAATATGATAAGTCACATTGATAGATTTTCATA
1521 TTATAAAACAACCTACTATGTGAGATTTATCCCAGGAATGTGTAGGTTGTTTTATCTGTTTGTTTTAATTAGGATCATTC
1601 TGGTCTCACAAAATGAATTATAAAATATTTTCTCCTTTTCAGTTTTCTGAAGTGTATCTGTCTTCTCAGAGAATCACTGT
1681 GGTTAAAATTGATAGTATTTTTTTCTTAATCATTTTTTAGAATTCACCAGTGAAGGCATCTGGGCTTAGACCTTTTCTTG
1761 CAAGAAGGTTTTTAACTACTAATTTAGTTATTTAATAGATATAGATTTACTTAGATTATCTGTTTCTTCTTGAGTGATCT
1841 TTGGCAGCTTGTGTGTTTTAAGGAACTTGTTCATTCCATGTAAATTATCAAATTTATTGGAAAAAGTTGTTTATGACATT
1921 CCGTTACTATTCTTTTGAAATCTGTTGAGATTATAGTGATATTAGTCTCATCTTGATATTGGTAATGTGTGTCTCCTCTG
2001 TTTTTTTTCTAGATCAGTTTGGCTAGATAGCTATGACATTTATTTGTATTTTCAAAGAATCAACTTTCGGTTTTATCTGT
2081 TTTTGCTTATTGTTTCCTATTTCATTGATTTATCCTCTAATTTTTATTATAATTTTCTTTGTTTGGCTTACTTTGAGTTT
2161 GGTTTTCTCCGCATTTTAATTTTTGAAATGGTAGCTGAGGCTATTGATTTGAGACCTTTCTTGTAATGTAGTCATTCCCT
2241 CTTAACTACTGCTTTAGTAGTATCTCAAAGATTGTGTTATGTTGCGTTTTCATTTTCATTCAGTTCAAAGTATTTCCAAT
2321 TTCACTTTTGTTTTCTTCTTTGACTTATGAGTTATTTAGAGGCATGCCACTTCGTTTTCAAATATTTGGGAGTTTTTTCA
2401 GAAATTTTTGTTGTTGATTTTTGATTCCGCTATAGTCAGAAAATATGTTTTTATGACTTTAAACATTTTAAATTTATTGA
2481 GACTAGTTTTTGGTCTAGATGGTCTATTGCTGTATTCAGTGTTCACTTTAAAATAATGTGTATCCACTTATTTATGGGTA
2561 TTTTATAAATGCCTGTTAGATAAAATCGGTTAATTATGTTATTCAAGTCTTCTGGAGCCTTTCTGATTTTCTGTCTTCTT
2641 GTATCAATATTTGAGAGAGGGGTATTAAAACCTCTGATTATGGACTTAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uaguuccAGGCGACACUUGUGc 5'
                 || ||||||||: | 
Target 5' gtagaatTCGGCTGTGAATCCa 3'
243 - 264 119.00 -13.00
2
miRNA  3' uaguuccAGGCGACACUUGUGc 5'
                 ||: |||||::||: 
Target 5' cttgcttTCTCCTGTGGGCATt 3'
764 - 785 115.00 -12.30
3
miRNA  3' uaguuccaggcgacaCUUGUGc 5'
                         |||||: 
Target 5' ctcattggtttcaaaGAACATc 3'
857 - 878 104.00 -7.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31963099 238 COSMIC
COSN4943861 549 COSMIC
COSN2307468 645 COSMIC
COSN4924741 799 COSMIC
COSN4924740 1295 COSMIC
COSN9697138 1662 COSMIC
COSN26539010 1802 COSMIC
COSN25903090 2026 COSMIC
COSN2307467 2074 COSMIC
COSN2307466 2268 COSMIC
COSN24375702 2286 COSMIC
COSN30249093 2410 COSMIC
COSN25128900 2481 COSMIC
COSN6377382 2557 COSMIC
COSN6377381 2614 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1490649931 2 dbSNP
rs1294519592 3 dbSNP
rs1251186046 7 dbSNP
rs1324374262 11 dbSNP
rs753738213 13 dbSNP
rs889593907 23 dbSNP
rs1354954142 29 dbSNP
rs1164384750 33 dbSNP
rs1270283177 37 dbSNP
rs1461077134 39 dbSNP
rs1241309499 43 dbSNP
rs1187292409 46 dbSNP
rs1229154075 47 dbSNP
rs570578179 49 dbSNP
rs1190943919 50 dbSNP
rs1346830180 59 dbSNP
rs1422918865 69 dbSNP
rs1049536479 71 dbSNP
rs1178033350 72 dbSNP
rs1403231870 77 dbSNP
rs932081579 79 dbSNP
rs899245075 83 dbSNP
rs1362903821 85 dbSNP
rs1038141646 88 dbSNP
rs1430038061 93 dbSNP
rs932862730 99 dbSNP
rs1359822428 103 dbSNP
rs1380816786 106 dbSNP
rs922838418 109 dbSNP
rs940665720 111 dbSNP
rs1225865836 116 dbSNP
rs547320271 117 dbSNP
rs140860162 118 dbSNP
rs949546668 119 dbSNP
rs908570792 125 dbSNP
rs1203226296 126 dbSNP
rs984189255 128 dbSNP
rs1394761098 136 dbSNP
rs916780244 144 dbSNP
rs990969968 148 dbSNP
rs952925421 152 dbSNP
rs945991452 163 dbSNP
rs958068642 164 dbSNP
rs925049957 165 dbSNP
rs978169073 178 dbSNP
rs1013149677 182 dbSNP
rs561879003 187 dbSNP
rs548299623 188 dbSNP
rs531566353 190 dbSNP
rs184523687 197 dbSNP
rs1366549422 198 dbSNP
rs1407330856 207 dbSNP
rs1186456024 215 dbSNP
rs1224471600 216 dbSNP
rs1008126293 219 dbSNP
rs1315407520 222 dbSNP
rs9775101 224 dbSNP
rs376853766 228 dbSNP
rs1488112690 229 dbSNP
rs1485126675 231 dbSNP
rs1028151651 239 dbSNP
rs1011304318 245 dbSNP
rs781441078 251 dbSNP
rs1386263520 256 dbSNP
rs1050215561 263 dbSNP
rs755176826 264 dbSNP
rs1037749259 275 dbSNP
rs1041312764 280 dbSNP
rs577513877 285 dbSNP
rs1371229273 292 dbSNP
rs908500053 296 dbSNP
rs1005309084 297 dbSNP
rs984540896 298 dbSNP
rs1247981420 300 dbSNP
rs560728707 301 dbSNP
rs751374653 305 dbSNP
rs1321097472 306 dbSNP
rs1205095362 313 dbSNP
rs1234145920 319 dbSNP
rs931359609 320 dbSNP
rs540506543 321 dbSNP
rs755665241 324 dbSNP
rs1162121350 325 dbSNP
rs1413490274 327 dbSNP
rs1375070992 328 dbSNP
rs779899142 329 dbSNP
rs1035492790 331 dbSNP
rs1352847772 336 dbSNP
rs1431947510 342 dbSNP
rs145488361 343 dbSNP
rs1385329218 349 dbSNP
rs949641470 359 dbSNP
rs1450693669 360 dbSNP
rs555473639 379 dbSNP
rs916834151 383 dbSNP
rs1215110053 387 dbSNP
rs1416650158 389 dbSNP
rs1274947480 390 dbSNP
rs758583067 393 dbSNP
rs1011647869 398 dbSNP
rs888812725 399 dbSNP
rs1462410193 401 dbSNP
rs1181330589 406 dbSNP
rs137930210 407 dbSNP
rs372627583 408 dbSNP
rs1475915247 421 dbSNP
rs1188801600 424 dbSNP
rs1252015458 440 dbSNP
rs1465548735 445 dbSNP
rs1177303751 446 dbSNP
rs1408347976 447 dbSNP
rs1468460277 464 dbSNP
rs1206859275 470 dbSNP
rs1333695426 471 dbSNP
rs750529134 482 dbSNP
rs997302248 483 dbSNP
rs1250574051 495 dbSNP
rs1217906611 496 dbSNP
rs1283406753 511 dbSNP
rs1325012751 513 dbSNP
rs1198389191 514 dbSNP
rs576066629 515 dbSNP
rs140283219 516 dbSNP
rs530039189 518 dbSNP
rs539714573 520 dbSNP
rs1200730905 521 dbSNP
rs1048664511 523 dbSNP
rs1354912314 543 dbSNP
rs750410089 547 dbSNP
rs1172064476 549 dbSNP
rs1409063691 551 dbSNP
rs931302924 552 dbSNP
rs7856659 556 dbSNP
rs991497307 564 dbSNP
rs35440891 567 dbSNP
rs1297939481 587 dbSNP
rs1346858747 587 dbSNP
rs533772760 594 dbSNP
rs1273715119 597 dbSNP
rs928446309 598 dbSNP
rs1034118718 601 dbSNP
rs1352117710 609 dbSNP
rs1223897372 610 dbSNP
rs1163360346 612 dbSNP
rs1450382015 620 dbSNP
rs977239779 624 dbSNP
rs1384394340 625 dbSNP
rs967267800 626 dbSNP
rs1471394258 637 dbSNP
rs1156999488 639 dbSNP
rs148781475 639 dbSNP
rs770043547 639 dbSNP
rs868546441 639 dbSNP
rs1367431848 641 dbSNP
rs1384981182 641 dbSNP
rs1249434823 643 dbSNP
rs1191556679 645 dbSNP
rs1306557195 646 dbSNP
rs1489376746 647 dbSNP
rs1263540471 649 dbSNP
rs1212993106 650 dbSNP
rs1334197340 653 dbSNP
rs1268871285 654 dbSNP
rs1294376308 655 dbSNP
rs867835750 661 dbSNP
rs1354913091 663 dbSNP
rs1230361437 665 dbSNP
rs567931585 668 dbSNP
rs548237283 676 dbSNP
rs1315317840 686 dbSNP
rs149139662 690 dbSNP
rs1439580868 694 dbSNP
rs1177011078 698 dbSNP
rs1237879975 699 dbSNP
rs1387694664 700 dbSNP
rs990125082 701 dbSNP
rs953154903 710 dbSNP
rs936820989 732 dbSNP
rs568911023 734 dbSNP
rs1369944886 739 dbSNP
rs1456357387 747 dbSNP
rs1162532795 749 dbSNP
rs925027517 751 dbSNP
rs1411089911 755 dbSNP
rs1328683058 760 dbSNP
rs977846255 768 dbSNP
rs374109251 770 dbSNP
rs1317649805 777 dbSNP
rs1339027423 782 dbSNP
rs1421807672 793 dbSNP
rs189591726 795 dbSNP
rs112073536 799 dbSNP
rs1342085469 801 dbSNP
rs1196888798 807 dbSNP
rs901612975 807 dbSNP
rs1014710180 811 dbSNP
rs1176355460 812 dbSNP
rs1004364908 815 dbSNP
rs529576349 817 dbSNP
rs1373641439 819 dbSNP
rs986426466 825 dbSNP
rs1049112658 827 dbSNP
rs953997781 830 dbSNP
rs1265036365 844 dbSNP
rs1028161591 848 dbSNP
rs995748087 852 dbSNP
rs1466054853 854 dbSNP
rs1167967519 857 dbSNP
rs931588735 859 dbSNP
rs962549653 861 dbSNP
rs1304159828 863 dbSNP
rs1400518459 864 dbSNP
rs1395875006 865 dbSNP
rs1296717364 870 dbSNP
rs1465271659 871 dbSNP
rs1016773193 876 dbSNP
rs1328760666 878 dbSNP
rs1004998919 887 dbSNP
rs886506636 888 dbSNP
rs1484967247 890 dbSNP
rs1254418774 897 dbSNP
rs184385705 898 dbSNP
rs1013586703 899 dbSNP
rs1055739142 901 dbSNP
rs938741652 902 dbSNP
rs7028470 904 dbSNP
rs1314261089 911 dbSNP
rs1055343447 918 dbSNP
rs936854260 924 dbSNP
rs7871810 928 dbSNP
rs945869841 929 dbSNP
rs192224249 936 dbSNP
rs914445963 950 dbSNP
rs544029998 952 dbSNP
rs990440076 953 dbSNP
rs541899218 955 dbSNP
rs1289863350 958 dbSNP
rs1362806095 963 dbSNP
rs912305101 985 dbSNP
rs761110186 990 dbSNP
rs986436603 1004 dbSNP
rs1383618309 1008 dbSNP
rs921576273 1012 dbSNP
rs975732209 1016 dbSNP
rs932278356 1020 dbSNP
rs1311870626 1023 dbSNP
rs1239981033 1029 dbSNP
rs865782317 1030 dbSNP
rs1489114688 1032 dbSNP
rs187788977 1047 dbSNP
rs973986685 1051 dbSNP
rs962932141 1054 dbSNP
rs1192472941 1060 dbSNP
rs1449917598 1066 dbSNP
rs1391933161 1070 dbSNP
rs965724629 1078 dbSNP
rs576251425 1079 dbSNP
rs1014679204 1087 dbSNP
rs760380213 1091 dbSNP
rs139947529 1094 dbSNP
rs1261156810 1095 dbSNP
rs1027154138 1097 dbSNP
rs996136045 1102 dbSNP
rs1025032380 1105 dbSNP
rs1201158660 1115 dbSNP
rs533520388 1117 dbSNP
rs1056003216 1120 dbSNP
rs565107162 1124 dbSNP
rs1002812705 1129 dbSNP
rs1311650584 1130 dbSNP
rs1343339290 1134 dbSNP
rs763187599 1138 dbSNP
rs34512437 1139 dbSNP
rs895124402 1139 dbSNP
rs1237759482 1140 dbSNP
rs1300365630 1142 dbSNP
rs1360128231 1144 dbSNP
rs1225912896 1147 dbSNP
rs545512482 1156 dbSNP
rs1001154432 1163 dbSNP
rs1312775910 1164 dbSNP
rs904099499 1165 dbSNP
rs907255182 1166 dbSNP
rs577043205 1170 dbSNP
rs1178464723 1180 dbSNP
rs1386208093 1187 dbSNP
rs945513561 1198 dbSNP
rs1163219874 1199 dbSNP
rs946160354 1204 dbSNP
rs1462618810 1205 dbSNP
rs1372181777 1207 dbSNP
rs868490556 1209 dbSNP
rs890878154 1213 dbSNP
rs1375014736 1218 dbSNP
rs1475030230 1220 dbSNP
rs1369025677 1222 dbSNP
rs1050776152 1225 dbSNP
rs867956255 1227 dbSNP
rs920966900 1228 dbSNP
rs147477725 1229 dbSNP
rs1310410061 1231 dbSNP
rs941328741 1238 dbSNP
rs1476259909 1244 dbSNP
rs1321046234 1248 dbSNP
rs931863904 1259 dbSNP
rs1255595555 1261 dbSNP
rs921826867 1262 dbSNP
rs1259404393 1264 dbSNP
rs908449227 1265 dbSNP
rs1456200744 1266 dbSNP
rs1187497731 1267 dbSNP
rs1197566288 1272 dbSNP
rs982622578 1275 dbSNP
rs564582516 1279 dbSNP
rs1473940094 1280 dbSNP
rs533846660 1282 dbSNP
rs1483566259 1295 dbSNP
rs1429604421 1298 dbSNP
rs1025083203 1300 dbSNP
rs149833883 1305 dbSNP
rs1398157846 1311 dbSNP
rs1277244082 1317 dbSNP
rs959709227 1318 dbSNP
rs1033724473 1324 dbSNP
rs1001264905 1325 dbSNP
rs904112810 1327 dbSNP
rs868723006 1330 dbSNP
rs1282200814 1331 dbSNP
rs1339272063 1333 dbSNP
rs1009707631 1337 dbSNP
rs1246338468 1344 dbSNP
rs1279565981 1347 dbSNP
rs150704482 1348 dbSNP
rs1217637802 1362 dbSNP
rs1051190901 1367 dbSNP
rs537940329 1368 dbSNP
rs899579341 1372 dbSNP
rs773748956 1373 dbSNP
rs1208522625 1374 dbSNP
rs1027536517 1375 dbSNP
rs775646673 1376 dbSNP
rs1196412896 1377 dbSNP
rs1326570340 1390 dbSNP
rs1477499943 1391 dbSNP
rs1038075192 1398 dbSNP
rs569043637 1408 dbSNP
rs552524141 1409 dbSNP
rs7027788 1423 dbSNP
rs908461018 1427 dbSNP
rs907178586 1428 dbSNP
rs1400550555 1429 dbSNP
rs1299887254 1431 dbSNP
rs1463017055 1432 dbSNP
rs762645593 1440 dbSNP
rs1415804160 1443 dbSNP
rs1187436249 1444 dbSNP
rs1046991016 1445 dbSNP
rs1274898384 1445 dbSNP
rs566873987 1450 dbSNP
rs949877704 1451 dbSNP
rs1346730391 1461 dbSNP
rs531821429 1465 dbSNP
rs755079708 1468 dbSNP
rs184829637 1472 dbSNP
rs1054970612 1476 dbSNP
rs1488243190 1480 dbSNP
rs931830702 1484 dbSNP
rs561463182 1489 dbSNP
rs868602252 1501 dbSNP
rs926664909 1502 dbSNP
rs866795156 1503 dbSNP
rs386737980 1504 dbSNP
rs10983269 1505 dbSNP
rs1420147620 1508 dbSNP
rs1160221431 1518 dbSNP
rs1228513317 1522 dbSNP
rs907511804 1523 dbSNP
rs747265168 1532 dbSNP
rs1441133958 1533 dbSNP
rs1331474489 1534 dbSNP
rs1325394864 1536 dbSNP
rs769467524 1538 dbSNP
rs1433871029 1539 dbSNP
rs1273815277 1549 dbSNP
rs113395792 1556 dbSNP
rs1242844998 1562 dbSNP
rs747600543 1564 dbSNP
rs1353674831 1574 dbSNP
rs1210918224 1576 dbSNP
rs1164267248 1578 dbSNP
rs1457900267 1582 dbSNP
rs920341967 1583 dbSNP
rs1239078105 1586 dbSNP
rs192625692 1594 dbSNP
rs1378206222 1602 dbSNP
rs1419040421 1603 dbSNP
rs1163708068 1605 dbSNP
rs1392271708 1613 dbSNP
rs1403168052 1614 dbSNP
rs1322294351 1615 dbSNP
rs1029822964 1618 dbSNP
rs997416963 1620 dbSNP
rs958859938 1621 dbSNP
rs1376564253 1625 dbSNP
rs1469887816 1635 dbSNP
rs899591369 1636 dbSNP
rs1246169429 1649 dbSNP
rs1378606064 1658 dbSNP
rs1286533090 1664 dbSNP
rs780102700 1674 dbSNP
rs758256105 1677 dbSNP
rs1005236328 1686 dbSNP
rs1209367282 1689 dbSNP
rs1258754992 1694 dbSNP
rs1196925647 1695 dbSNP
rs886746156 1704 dbSNP
rs1046752723 1713 dbSNP
rs1187998672 1723 dbSNP
rs971640358 1726 dbSNP
rs949972872 1736 dbSNP
rs1163636046 1738 dbSNP
rs1400345577 1740 dbSNP
rs1208792785 1743 dbSNP
rs1201132275 1747 dbSNP
rs112633890 1754 dbSNP
rs1328797175 1756 dbSNP
rs750225675 1758 dbSNP
rs138531283 1761 dbSNP
rs187827474 1767 dbSNP
rs1281614104 1768 dbSNP
rs1339266555 1773 dbSNP
rs893165009 1779 dbSNP
rs1345388423 1786 dbSNP
rs10739469 1788 dbSNP
rs182757798 1792 dbSNP
rs1370155598 1797 dbSNP
rs1040248192 1801 dbSNP
rs10983268 1802 dbSNP
rs968144421 1803 dbSNP
rs1257974639 1804 dbSNP
rs1435833346 1804 dbSNP
rs1187080114 1816 dbSNP
rs913926121 1817 dbSNP
rs1478554294 1822 dbSNP
rs1167899640 1826 dbSNP
rs988098107 1830 dbSNP
rs955657940 1832 dbSNP
rs376102461 1843 dbSNP
rs997029624 1851 dbSNP
rs1426187984 1853 dbSNP
rs964538650 1869 dbSNP
rs1400446395 1882 dbSNP
rs1016697513 1883 dbSNP
rs1005742544 1887 dbSNP
rs1453025973 1890 dbSNP
rs886840125 1891 dbSNP
rs1025354912 1908 dbSNP
rs1398294168 1909 dbSNP
rs1277624327 1914 dbSNP
rs1394943467 1915 dbSNP
rs554328954 1922 dbSNP
rs537678583 1923 dbSNP
rs1210082938 1924 dbSNP
rs895737856 1929 dbSNP
rs1055696794 1947 dbSNP
rs1190926071 1949 dbSNP
rs937203402 1956 dbSNP
rs1433430687 1959 dbSNP
rs1020531411 1962 dbSNP
rs904381900 1965 dbSNP
rs1042875975 1970 dbSNP
rs946828133 1973 dbSNP
rs1376284800 1979 dbSNP
rs1159618955 1999 dbSNP
rs1434558680 1999 dbSNP
rs1282104260 2004 dbSNP
rs1418381877 2009 dbSNP
rs913978580 2022 dbSNP
rs988111288 2030 dbSNP
rs575419984 2033 dbSNP
rs922877800 2040 dbSNP
rs558749646 2044 dbSNP
rs1330726827 2051 dbSNP
rs1033429045 2053 dbSNP
rs539130736 2054 dbSNP
rs1355805986 2055 dbSNP
rs964314631 2056 dbSNP
rs1214293914 2067 dbSNP
rs56396947 2068 dbSNP
rs1216289877 2069 dbSNP
rs1488482390 2079 dbSNP
rs191233562 2086 dbSNP
rs763712167 2099 dbSNP
rs1264905073 2112 dbSNP
rs555987282 2115 dbSNP
rs900599236 2126 dbSNP
rs1359949346 2127 dbSNP
rs73528716 2128 dbSNP
rs117711705 2135 dbSNP
rs886312415 2139 dbSNP
rs895454517 2141 dbSNP
rs1169725821 2146 dbSNP
rs1412107052 2161 dbSNP
rs1034004761 2164 dbSNP
rs551170739 2170 dbSNP
rs115214642 2171 dbSNP
rs1043314765 2173 dbSNP
rs945850637 2189 dbSNP
rs565486408 2190 dbSNP
rs1322238142 2194 dbSNP
rs892554346 2204 dbSNP
rs1052450557 2227 dbSNP
rs879109670 2230 dbSNP
rs551940385 2231 dbSNP
rs773551045 2238 dbSNP
rs1467780467 2240 dbSNP
rs1485200340 2244 dbSNP
rs145932056 2246 dbSNP
rs1206425002 2248 dbSNP
rs765796397 2254 dbSNP
rs922633485 2256 dbSNP
rs1456670737 2260 dbSNP
rs1305689053 2262 dbSNP
rs975422973 2273 dbSNP
rs942987004 2276 dbSNP
rs10983267 2284 dbSNP
rs1356181267 2285 dbSNP
rs539876717 2286 dbSNP
rs777062007 2288 dbSNP
rs574368275 2293 dbSNP
rs1439822912 2298 dbSNP
rs1297375468 2304 dbSNP
rs1379860642 2310 dbSNP
rs1413190056 2317 dbSNP
rs1355112605 2319 dbSNP
rs1290933352 2330 dbSNP
rs553464675 2330 dbSNP
rs1444903918 2341 dbSNP
rs1218869393 2343 dbSNP
rs1259666499 2347 dbSNP
rs1456163610 2362 dbSNP
rs1353259109 2363 dbSNP
rs1204314276 2367 dbSNP
rs1025409449 2369 dbSNP
rs1484538469 2373 dbSNP
rs560822852 2374 dbSNP
rs959759047 2379 dbSNP
rs1034469366 2384 dbSNP
rs142331602 2386 dbSNP
rs1474664291 2389 dbSNP
rs575304230 2393 dbSNP
rs1172890665 2398 dbSNP
rs1421816150 2399 dbSNP
rs969046644 2401 dbSNP
rs1169526356 2407 dbSNP
rs558718689 2410 dbSNP
rs1252177017 2411 dbSNP
rs1450147990 2413 dbSNP
rs1021504825 2416 dbSNP
rs1010043965 2423 dbSNP
rs533864375 2428 dbSNP
rs1232165762 2429 dbSNP
rs188014291 2432 dbSNP
rs116199837 2433 dbSNP
rs1209168209 2435 dbSNP
rs1001808007 2437 dbSNP
rs182757156 2439 dbSNP
rs567998654 2441 dbSNP
rs1231570890 2444 dbSNP
rs138162179 2446 dbSNP
rs1475223541 2446 dbSNP
rs371753923 2446 dbSNP
rs201162264 2447 dbSNP
rs565890845 2455 dbSNP
rs1425615287 2459 dbSNP
rs1416027205 2472 dbSNP
rs1308054574 2474 dbSNP
rs1171510773 2478 dbSNP
rs1393444643 2479 dbSNP
rs913375752 2480 dbSNP
rs1371640925 2492 dbSNP
rs536670109 2498 dbSNP
rs1420188310 2509 dbSNP
rs1324112074 2512 dbSNP
rs1429595899 2513 dbSNP
rs1275139472 2515 dbSNP
rs35536666 2534 dbSNP
rs1298068005 2537 dbSNP
rs548159910 2538 dbSNP
rs1442314620 2540 dbSNP
rs1051536195 2544 dbSNP
rs1232615211 2547 dbSNP
rs1280019662 2553 dbSNP
rs1355088410 2557 dbSNP
rs1053707173 2565 dbSNP
rs1446438762 2567 dbSNP
rs998251243 2569 dbSNP
rs1452786841 2571 dbSNP
rs936209781 2577 dbSNP
rs1394196993 2581 dbSNP
rs1440253582 2587 dbSNP
rs114175562 2588 dbSNP
rs1040145389 2590 dbSNP
rs975029790 2594 dbSNP
rs964700314 2596 dbSNP
rs1323617820 2603 dbSNP
rs1351295384 2604 dbSNP
rs1160844396 2605 dbSNP
rs911905914 2606 dbSNP
rs190578695 2615 dbSNP
rs185962959 2617 dbSNP
rs1469736061 2619 dbSNP
rs942676357 2620 dbSNP
rs529606489 2621 dbSNP
rs1048609172 2628 dbSNP
rs537754072 2635 dbSNP
rs149376437 2643 dbSNP
rs375408522 2643 dbSNP
rs930196162 2643 dbSNP
rs1458099008 2647 dbSNP
rs571746639 2648 dbSNP
rs1362037541 2657 dbSNP
rs1261467576 2658 dbSNP
rs1002082959 2659 dbSNP
rs1459562181 2662 dbSNP
rs181823208 2671 dbSNP
rs1400575746 2672 dbSNP
rs992992849 2677 dbSNP
rs1024614632 2689 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000341734.4 | 3UTR | ACACAGAUGUGUGUGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE32688 Pancreatic cancer 0.334 3.1e-2 0.103 2.9e-1 32 Click to see details
GSE28260 Renal cortex and medulla 0.428 7.2e-2 0.374 1.0e-1 13 Click to see details
GSE19350 CNS germ cell tumors -0.432 8.0e-2 0.028 4.7e-1 12 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.253 1.1e-1 0.243 1.2e-1 25 Click to see details
GSE28544 Breast cancer 0.233 1.4e-1 0.140 2.6e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.159 2.5e-1 0.337 7.3e-2 20 Click to see details
GSE17498 Multiple myeloma 0.1 2.7e-1 0.108 2.5e-1 40 Click to see details
GSE42095 Differentiated embryonic stem cells -0.121 2.9e-1 -0.230 1.5e-1 23 Click to see details
GSE21687 Ependynoma primary tumors -0.068 3.0e-1 -0.149 1.2e-1 64 Click to see details
GSE26953 Aortic valvular endothelial cells 0.05 4.1e-1 -0.111 3.0e-1 24 Click to see details
GSE38226 Liver fibrosis -0.05 4.1e-1 -0.210 1.8e-1 21 Click to see details
GSE38226 Liver fibrosis -0.05 4.1e-1 -0.210 1.8e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
-0.05 4.1e-1 -0.210 1.8e-1 21 Click to see details
-0.05 4.1e-1 -0.210 1.8e-1 21 Click to see details
-0.05 4.1e-1 -0.210 1.8e-1 21 Click to see details
65 hsa-miR-124-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064177 KIAA1804 mitogen-activated protein kinase kinase kinase 21 2 2
MIRT069736 FOXG1 forkhead box G1 2 4
MIRT086429 NABP1 nucleic acid binding protein 1 2 6
MIRT105334 SLC7A2 solute carrier family 7 member 2 2 4
MIRT110455 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT172998 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT196428 TAOK1 TAO kinase 1 2 14
MIRT325704 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT365670 TSC22D3 TSC22 domain family member 3 2 4
MIRT365873 XIAP X-linked inhibitor of apoptosis 2 2
MIRT404126 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT404626 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT405284 ARF1 ADP ribosylation factor 1 2 2
MIRT406099 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT446627 SDC3 syndecan 3 2 2
MIRT446906 RGS5 regulator of G protein signaling 5 2 2
MIRT461790 FXR2 FMR1 autosomal homolog 2 2 2
MIRT463982 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT464204 VGLL4 vestigial like family member 4 2 2
MIRT472790 MTMR4 myotubularin related protein 4 2 4
MIRT473485 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT481124 AZIN1 antizyme inhibitor 1 2 4
MIRT485060 SUCO SUN domain containing ossification factor 2 2
MIRT487343 HLA-DRA major histocompatibility complex, class II, DR alpha 2 2
MIRT491948 VPS52 VPS52, GARP complex subunit 2 2
MIRT497208 CDH7 cadherin 7 2 2
MIRT497476 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT528203 NELFE negative elongation factor complex member E 2 2
MIRT529255 TRIM4 tripartite motif containing 4 2 4
MIRT530096 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530597 C7orf33 chromosome 7 open reading frame 33 2 4
MIRT534980 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT538326 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2 2
MIRT561237 ZNF652 zinc finger protein 652 2 2
MIRT562035 KRAS KRAS proto-oncogene, GTPase 2 2
MIRT563120 THAP5 THAP domain containing 5 2 2
MIRT563538 RBM41 RNA binding motif protein 41 2 2
MIRT566037 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT566505 PAWR pro-apoptotic WT1 regulator 2 2
MIRT566745 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT566850 LRRC58 leucine rich repeat containing 58 2 2
MIRT568077 CELF2 CUGBP Elav-like family member 2 2 2
MIRT576826 Tgfbr3 transforming growth factor, beta receptor III 2 2
MIRT608870 NR2E1 nuclear receptor subfamily 2 group E member 1 2 4
MIRT611997 VAC14 Vac14, PIKFYVE complex component 2 2
MIRT614054 FAM89A family with sequence similarity 89 member A 2 2
MIRT618800 SPATA21 spermatogenesis associated 21 2 2
MIRT619389 RSPH3 radial spoke head 3 homolog 2 2
MIRT622282 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624026 EN2 engrailed homeobox 2 2 2
MIRT626000 MPEG1 macrophage expressed 1 2 2
MIRT641792 USP32 ubiquitin specific peptidase 32 2 2
MIRT651599 WDFY2 WD repeat and FYVE domain containing 2 2 2
MIRT659662 CDC73 cell division cycle 73 2 2
MIRT663010 KIAA1586 KIAA1586 2 2
MIRT663561 ASTN2 astrotactin 2 2 2
MIRT669312 C16orf72 chromosome 16 open reading frame 72 2 2
MIRT685216 POTED POTE ankyrin domain family member D 2 2
MIRT695757 ZNF117 zinc finger protein 117 2 2
MIRT697909 TXNRD1 thioredoxin reductase 1 2 2
MIRT707181 RPH3A rabphilin 3A 2 2
MIRT707214 TRIM13 tripartite motif containing 13 2 2
MIRT707478 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT719507 LMAN2L lectin, mannose binding 2 like 2 2
MIRT755814 PARP1 poly(ADP-ribose) polymerase 1 2 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-124 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) NULL 16078949 Microarray hepatocytes 23107762 2013 up-regulated
miR-124 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-124 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-124 Cocaine NULL 446220 Quantitative real-time PCR HEK293 cells or rat brain parts 19703567 2009 down-regulated
miR-124 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-124 Chaihu Shugan San NULL NULL Microarray hippocampus 23947143 2013 up-regualted
miR-124 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-124 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved resistant High Laryngeal Cancer cell line (Hep2)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (MGC803)
hsa-miR-124-5p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-124-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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