pre-miRNA Information
pre-miRNA hsa-mir-1245a   
Genomic Coordinates chr2: 188978092 - 188978161
Description Homo sapiens miR-1245a stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1245a
Sequence 45| AAGUGAUCUAAAGGCCUACAU |65
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31562560 15 COSMIC
COSN26581044 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs906938680 2 dbSNP
rs1159117523 3 dbSNP
rs780486044 6 dbSNP
rs771479866 17 dbSNP
rs1002976932 18 dbSNP
rs1428029219 19 dbSNP
Putative Targets

Gene Information
Gene Symbol ZNF554   
Synonyms -
Description zinc finger protein 554
Transcript NM_001102651   
Expression
Putative miRNA Targets on ZNF554
3'UTR of ZNF554
(miRNA target sites are highlighted)
>ZNF554|NM_001102651|3'UTR
   1 CAATTGCACGCTGCTTTGTAAGCCACTTTTTAGTACTCTGACACATACATGTGGTTATCTTTTGCCCTGTTGTGATGGAT
  81 AATTTGAAAAGAAGTGGGTTTATGTCACCTTCTCACCTTCTTATAAGAAAGCTCTGAGAATGGGCATTTTTGTATTTTGT
 161 TGTTGTTGTTGAGATGGAGTCTGCCACCCAGGCTGGAGTCCAGTGGCGTGATCATACCTCACTGCAGCTTCAACTTCCTG
 241 GGCTCAAGTAATCCTCCCACCCCAGCCTCCCAGGTAGCTAGTACTATAGGTGTGCACCACCACGCCCAGCAAATTTTTAA
 321 ATTTATTATAGAGTGGGAGGCAGGGTGCGGTGGCTCATGCCTATAATCCTAACACTTTAGGAGGCCGAGGCGGGTGGATC
 401 ATGAGGTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACCCTGTCTCTACTAAAAATACAAAAAAGTAGCCGGGC
 481 GTGGTGGTGGGCGCCTGTAGTCCCAACTACTCAGGAGGCTGAGGCAGGAGAATGGTGTGAACCCGGGAGGTGGAGCTTGC
 561 AGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGGAGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAATTATA
 641 GAGTTGGGGTCTTGCTACATTGCCAAGACTGGTCTTGAACTCCTGGGGTCAAGCATCCTCCTGTCTTGGCCTCCCAAAGT
 721 GTTGGGATTAGAAGCATGAGCCGCTGTGCCCAGCCTGACGGGGCCTTTTAGTGGGAGGAGTTGCCATTACACTACGTCCA
 801 GTAAGCTCCAGACTTTCGGAAAAGATTGGTGGACGGGAATGCTGTCATGGATGGGATCTTGCCAAGAACCATCACGTGTT
 881 AATTTAGTTGCTTAAACAAAAGGTGTTCTGTTTCTTAACTACTTCTGTGTCTTTACTTTTTATTTCATTGTTCATTGTTT
 961 TTATTTTAATATTCTTTTCTGGGTTTATATGAGACGAGTTTTCACTCTGTTGCTGAGGCTGAAGTGCAGTGGCGTGATCA
1041 TAGCTCCCTGTAGTCAGCCTTCATCTCCTGGACTCAAGCAATCCTCCCACCTCAGCCTCTCCGGTAGCTGGGACTACACA
1121 TGTGCACCGCTACCACACCCAGCTAAATTTTTTTTTTGTATTTTTGTAGTGATGGGCTTTCACCAGGTTGCCCAGGCTGG
1201 TCTCAAACTCCTGAGCTCAAGCAATCCACCCACCTTGGCCTCCCAAAGTGCTGGTATTACAGGTGTGAGCCACCGTGCTG
1281 GTATTACGGGTGTGAGCCACTGTGCTGGGATTACGGGCGTGAGCTGCCCATGCTGGGATTACGGGTGTGAGCCACCGTGC
1361 TGGTATTACGGGTGTGAGCCACCGTGCTGGGATTACGGGCGTGAGCCACTGTGCTGGGATTACGGGCGCGAGCCACTGTG
1441 CTGGGATTACAGGTGTGAGCCACCCTGCTGGGATTATGGGTGCGAGCCGCCGTGCTGGGATTACAGGTGTGAACCACTGC
1521 TCCTGGCCTTTATTTCAGCATTCTGTTTCAGTGTTTCACATTGGCCACTTAGCTAGATCCGTTTGTCTTCTGCAGTACTG
1601 TGCTGATCCAGAGTATATGCTAAGACGGAAAGCGCTTTGGAGGTAAAGTTTAAAAAATACAAGGGCTTCAAAATAGTACT
1681 AGTAATTTGATCCATTCACAAAAGGACAAAGGCTGGACAGAGACGTGAAGAAATGAATCATTTACGCAATGATTGGGGTG
1761 TTCCAATTATGTGTGATTTTGTGTTTTCTGCCGTTTCATTTTGTATTGCCATAATCATTTTGACAATGAATACAAATCAA
1841 ATAGCACCCAAAATTGTGAAGGATACGGAACCTCATTGATGAG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uacaUCCGGAAAUCUAGUGaa 5'
              ||||   |:|||||:  
Target 5' gccgAGGCGGGTGGATCATga 3'
384 - 404 121.00 -12.40
2
miRNA  3' uaCAUCCGGAAAUCUAGUGaa 5'
            ||: |||   |||||:|  
Target 5' caGTGAGCC--GAGATCGCac 3'
560 - 578 119.00 -15.10
3
miRNA  3' uaCAUCCGGAAAUCUAGUGaa 5'
            || ||| |   |||||:  
Target 5' caGT-GGCGT---GATCATac 3'
201 - 217 111.00 -7.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30131317 65 COSMIC
COSN30461173 110 COSMIC
COSN24834656 170 COSMIC
COSN1764212 245 COSMIC
COSN7052452 615 COSMIC
COSN7120858 760 COSMIC
COSN27575229 796 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1225344498 3 dbSNP
rs775478154 5 dbSNP
rs760982581 7 dbSNP
rs1016753999 8 dbSNP
rs188183451 10 dbSNP
rs750018067 11 dbSNP
rs997070924 12 dbSNP
rs1340967439 13 dbSNP
rs1212411418 15 dbSNP
rs1291427663 16 dbSNP
rs762720202 17 dbSNP
rs1028170115 18 dbSNP
rs765998053 18 dbSNP
rs1045031919 24 dbSNP
rs1208104439 26 dbSNP
rs575554970 27 dbSNP
rs751120323 37 dbSNP
rs754849116 38 dbSNP
rs781224191 40 dbSNP
rs752711595 41 dbSNP
rs1414666421 47 dbSNP
rs1460930596 49 dbSNP
rs1162858008 50 dbSNP
rs755907820 51 dbSNP
rs1402990030 55 dbSNP
rs369780432 62 dbSNP
rs1329234490 65 dbSNP
rs542720826 68 dbSNP
rs1410754140 69 dbSNP
rs1381320759 70 dbSNP
rs1421870620 73 dbSNP
rs1240321231 77 dbSNP
rs1280911384 82 dbSNP
rs1348156082 97 dbSNP
rs1477566025 98 dbSNP
rs905291570 115 dbSNP
rs201305142 117 dbSNP
rs867654255 117 dbSNP
rs560932452 118 dbSNP
rs1489999133 119 dbSNP
rs1279733635 127 dbSNP
rs913535005 140 dbSNP
rs1462954536 141 dbSNP
rs1032826340 143 dbSNP
rs966340466 156 dbSNP
rs772812826 157 dbSNP
rs1270385356 177 dbSNP
rs1217607939 178 dbSNP
rs1323671674 180 dbSNP
rs1243075354 184 dbSNP
rs1221667865 194 dbSNP
rs1458260308 202 dbSNP
rs979103658 208 dbSNP
rs925003167 209 dbSNP
rs1009737650 212 dbSNP
rs1352524897 214 dbSNP
rs1329610255 215 dbSNP
rs937807153 216 dbSNP
rs965588350 217 dbSNP
rs1178605719 224 dbSNP
rs976157354 226 dbSNP
rs1425031243 228 dbSNP
rs1055674764 229 dbSNP
rs1471387585 230 dbSNP
rs953263305 234 dbSNP
rs984587198 242 dbSNP
rs1470837682 248 dbSNP
rs757879710 251 dbSNP
rs1201192219 252 dbSNP
rs949578221 255 dbSNP
rs1311557545 260 dbSNP
rs1284933766 262 dbSNP
rs1405334765 268 dbSNP
rs1370996883 270 dbSNP
rs1048017787 278 dbSNP
rs1391438989 280 dbSNP
rs886725944 287 dbSNP
rs1439133267 297 dbSNP
rs1383717198 298 dbSNP
rs193262022 304 dbSNP
rs528213349 305 dbSNP
rs900555844 309 dbSNP
rs1358626876 314 dbSNP
rs917832972 319 dbSNP
rs996293732 322 dbSNP
rs1028535050 323 dbSNP
rs1444900443 327 dbSNP
rs949279075 346 dbSNP
rs955214601 349 dbSNP
rs905219049 350 dbSNP
rs1222129345 354 dbSNP
rs539798418 355 dbSNP
rs1260799648 357 dbSNP
rs1217940034 360 dbSNP
rs1001258019 361 dbSNP
rs1008047701 362 dbSNP
rs892548793 364 dbSNP
rs1009748930 366 dbSNP
rs1020823122 372 dbSNP
rs1317489645 376 dbSNP
rs1198111961 378 dbSNP
rs1394477858 379 dbSNP
rs564905575 387 dbSNP
rs73526343 388 dbSNP
rs997080355 391 dbSNP
rs1028980714 392 dbSNP
rs185413930 393 dbSNP
rs964275566 396 dbSNP
rs569895661 403 dbSNP
rs1174055590 409 dbSNP
rs1428471290 411 dbSNP
rs1387438841 416 dbSNP
rs959361041 417 dbSNP
rs990589700 418 dbSNP
rs1393620650 428 dbSNP
rs1015974875 430 dbSNP
rs1262326540 439 dbSNP
rs1303373824 448 dbSNP
rs961731163 456 dbSNP
rs751453986 457 dbSNP
rs531045609 458 dbSNP
rs1242955969 477 dbSNP
rs75377257 477 dbSNP
rs1282998172 478 dbSNP
rs1047966261 481 dbSNP
rs567623880 482 dbSNP
rs781258601 483 dbSNP
rs1338496636 484 dbSNP
rs535118985 485 dbSNP
rs1406089240 486 dbSNP
rs1367915584 492 dbSNP
rs1038083001 493 dbSNP
rs764671665 494 dbSNP
rs1373248915 511 dbSNP
rs1171930830 515 dbSNP
rs1338824746 518 dbSNP
rs1223399551 521 dbSNP
rs1422244946 532 dbSNP
rs1200138678 533 dbSNP
rs932024321 537 dbSNP
rs1481368029 538 dbSNP
rs1265012588 544 dbSNP
rs79667368 545 dbSNP
rs890577163 546 dbSNP
rs1200728221 560 dbSNP
rs1316217590 562 dbSNP
rs148864349 569 dbSNP
rs2317036 570 dbSNP
rs902411616 572 dbSNP
rs781537182 575 dbSNP
rs1195158424 576 dbSNP
rs955316228 581 dbSNP
rs945419993 582 dbSNP
rs1000809696 595 dbSNP
rs1397630667 599 dbSNP
rs1299564829 602 dbSNP
rs1463729448 607 dbSNP
rs1041247628 608 dbSNP
rs988553038 615 dbSNP
rs1481377703 616 dbSNP
rs1337936130 619 dbSNP
rs1021037186 620 dbSNP
rs10695177 620 dbSNP
rs1204342129 620 dbSNP
rs1257512312 620 dbSNP
rs1456567297 620 dbSNP
rs3059202 620 dbSNP
rs1347780085 625 dbSNP
rs1254811526 629 dbSNP
rs1233123827 631 dbSNP
rs959079304 632 dbSNP
rs1336791050 635 dbSNP
rs557320354 636 dbSNP
rs1163710947 643 dbSNP
rs1366934225 644 dbSNP
rs1422312031 645 dbSNP
rs1375608073 647 dbSNP
rs990927656 648 dbSNP
rs575494088 649 dbSNP
rs1302165214 651 dbSNP
rs970489262 657 dbSNP
rs1363013181 661 dbSNP
rs1454238596 664 dbSNP
rs1365339198 679 dbSNP
rs997406925 683 dbSNP
rs1438100287 684 dbSNP
rs147998793 685 dbSNP
rs1294047797 686 dbSNP
rs536135748 688 dbSNP
rs908059539 694 dbSNP
rs942219593 703 dbSNP
rs1200444557 705 dbSNP
rs1317196110 727 dbSNP
rs1357394661 735 dbSNP
rs1005887740 737 dbSNP
rs973688593 743 dbSNP
rs922210081 744 dbSNP
rs554752980 749 dbSNP
rs971815450 750 dbSNP
rs968564253 755 dbSNP
rs1449771031 758 dbSNP
rs767427441 759 dbSNP
rs1206732456 760 dbSNP
rs779308356 761 dbSNP
rs1427808687 762 dbSNP
rs936548945 764 dbSNP
rs1385598901 770 dbSNP
rs890524793 773 dbSNP
rs1164519124 788 dbSNP
rs879621639 796 dbSNP
rs1042181321 797 dbSNP
rs913876406 799 dbSNP
rs1265910600 806 dbSNP
rs1215051041 810 dbSNP
rs528492889 818 dbSNP
rs557724113 819 dbSNP
rs1229695122 830 dbSNP
rs780257734 835 dbSNP
rs1283124695 836 dbSNP
rs1227460926 838 dbSNP
rs932842816 840 dbSNP
rs1050311429 844 dbSNP
rs1296308484 847 dbSNP
rs895095273 852 dbSNP
rs564726458 853 dbSNP
rs1011897810 854 dbSNP
rs1455654692 862 dbSNP
rs377427509 866 dbSNP
rs1287525849 870 dbSNP
rs112155892 876 dbSNP
rs749504482 877 dbSNP
rs1006185866 899 dbSNP
rs970441713 900 dbSNP
rs1192200072 915 dbSNP
rs983201663 917 dbSNP
rs1015065925 918 dbSNP
rs545283295 922 dbSNP
rs963568966 928 dbSNP
rs1270060214 931 dbSNP
rs1224187182 932 dbSNP
rs1015783091 938 dbSNP
rs974018308 948 dbSNP
rs375258613 954 dbSNP
rs932252906 962 dbSNP
rs987401730 963 dbSNP
rs911913879 973 dbSNP
rs546751137 988 dbSNP
rs970851891 994 dbSNP
rs946098667 996 dbSNP
rs1002048176 997 dbSNP
rs1041793545 998 dbSNP
rs531130098 1005 dbSNP
rs768732798 1009 dbSNP
rs926074400 1010 dbSNP
rs1466328156 1012 dbSNP
rs191333202 1020 dbSNP
rs1054052953 1032 dbSNP
rs957994198 1033 dbSNP
rs566773528 1034 dbSNP
rs567854826 1035 dbSNP
rs1182148309 1040 dbSNP
rs529063403 1041 dbSNP
rs1046059080 1043 dbSNP
rs1197409132 1050 dbSNP
rs1324210101 1054 dbSNP
rs1280708648 1060 dbSNP
rs1217372834 1061 dbSNP
rs368027279 1066 dbSNP
rs1279862491 1069 dbSNP
rs1004583983 1077 dbSNP
rs1459584576 1081 dbSNP
rs1180827972 1082 dbSNP
rs1329422072 1094 dbSNP
rs1446198042 1102 dbSNP
rs528567234 1103 dbSNP
rs1178955472 1104 dbSNP
rs1413253022 1113 dbSNP
rs760708269 1114 dbSNP
rs1159558544 1117 dbSNP
rs1441196371 1118 dbSNP
rs1235922188 1119 dbSNP
rs1177597075 1121 dbSNP
rs1461408193 1124 dbSNP
rs1420457012 1125 dbSNP
rs775574335 1129 dbSNP
rs932705132 1130 dbSNP
rs1049938833 1134 dbSNP
rs747057004 1139 dbSNP
rs1470509520 1143 dbSNP
rs1037283110 1148 dbSNP
rs879795870 1148 dbSNP
rs769264025 1152 dbSNP
rs1446322273 1158 dbSNP
rs1339260073 1159 dbSNP
rs897405866 1159 dbSNP
rs1404611199 1160 dbSNP
rs1451977061 1161 dbSNP
rs993134096 1162 dbSNP
rs1446466792 1174 dbSNP
rs547117571 1176 dbSNP
rs1029586594 1183 dbSNP
rs1378818561 1184 dbSNP
rs550390766 1185 dbSNP
rs1157743645 1188 dbSNP
rs1423975014 1195 dbSNP
rs1415341219 1196 dbSNP
rs953633863 1201 dbSNP
rs987687259 1228 dbSNP
rs1482901175 1248 dbSNP
rs1263877789 1252 dbSNP
rs911861323 1256 dbSNP
rs1239710077 1262 dbSNP
rs1285031893 1262 dbSNP
rs1033422103 1264 dbSNP
rs1306567860 1265 dbSNP
rs1314978204 1265 dbSNP
rs967345922 1268 dbSNP
rs1226628510 1271 dbSNP
rs958135616 1273 dbSNP
rs977432709 1275 dbSNP
rs926042619 1276 dbSNP
rs936112784 1282 dbSNP
rs369788375 1283 dbSNP
rs1162233665 1287 dbSNP
rs777100894 1288 dbSNP
rs568808763 1289 dbSNP
rs571528042 1291 dbSNP
rs373931085 1292 dbSNP
rs947918345 1293 dbSNP
rs1210172316 1294 dbSNP
rs966578230 1299 dbSNP
rs1219604859 1300 dbSNP
rs56010141 1302 dbSNP
rs1258776372 1303 dbSNP
rs1221011494 1308 dbSNP
rs1321384059 1310 dbSNP
rs1277993482 1316 dbSNP
rs1046337123 1319 dbSNP
rs906487264 1320 dbSNP
rs1370141197 1321 dbSNP
rs1291498740 1324 dbSNP
rs1457085915 1325 dbSNP
rs1400409443 1326 dbSNP
rs1464026662 1327 dbSNP
rs976767577 1327 dbSNP
rs1422772086 1330 dbSNP
rs1199462734 1331 dbSNP
rs926431375 1338 dbSNP
rs1481334753 1343 dbSNP
rs371165269 1344 dbSNP
rs1004531429 1345 dbSNP
rs56065950 1347 dbSNP
rs55780459 1349 dbSNP
rs922566500 1352 dbSNP
rs1175048977 1357 dbSNP
rs569127316 1358 dbSNP
rs536559896 1364 dbSNP
rs55660536 1365 dbSNP
rs1299573788 1367 dbSNP
rs1385879023 1369 dbSNP
rs898883209 1370 dbSNP
rs56309832 1371 dbSNP
rs1443999738 1372 dbSNP
rs1029125483 1374 dbSNP
rs1173152772 1375 dbSNP
rs953682875 1382 dbSNP
rs1009055470 1384 dbSNP
rs147704774 1385 dbSNP
rs1037129448 1392 dbSNP
rs55877321 1397 dbSNP
rs977380484 1398 dbSNP
rs1249894916 1399 dbSNP
rs1297811292 1400 dbSNP
rs925960041 1401 dbSNP
rs114347844 1402 dbSNP
rs1405300247 1403 dbSNP
rs56372229 1403 dbSNP
rs1354835871 1406 dbSNP
rs1284913850 1410 dbSNP
rs56379421 1411 dbSNP
rs906220238 1414 dbSNP
rs1218513115 1415 dbSNP
rs373645526 1420 dbSNP
rs576547023 1424 dbSNP
rs947864951 1425 dbSNP
rs1273437004 1428 dbSNP
rs543775552 1429 dbSNP
rs184287792 1430 dbSNP
rs115230208 1431 dbSNP
rs1036002841 1436 dbSNP
rs1029841 1438 dbSNP
rs930378821 1439 dbSNP
rs1187612641 1441 dbSNP
rs151211646 1446 dbSNP
rs1408258446 1447 dbSNP
rs1168086889 1452 dbSNP
rs1214018573 1455 dbSNP
rs888912458 1463 dbSNP
rs1284303102 1465 dbSNP
rs1366310923 1465 dbSNP
rs2012992 1466 dbSNP
rs546761400 1478 dbSNP
rs140402279 1480 dbSNP
rs532657581 1482 dbSNP
rs550954178 1483 dbSNP
rs1418137305 1484 dbSNP
rs1301536303 1485 dbSNP
rs1363408333 1489 dbSNP
rs72982740 1490 dbSNP
rs188648699 1492 dbSNP
rs548495131 1493 dbSNP
rs1212265375 1498 dbSNP
rs1478401288 1503 dbSNP
rs1265798606 1506 dbSNP
rs1191903411 1507 dbSNP
rs957593054 1508 dbSNP
rs991544344 1511 dbSNP
rs200942202 1514 dbSNP
rs1290198797 1517 dbSNP
rs1211261115 1520 dbSNP
rs972895804 1523 dbSNP
rs1023451570 1533 dbSNP
rs1224172435 1537 dbSNP
rs1219178324 1541 dbSNP
rs150383493 1549 dbSNP
rs1276092323 1562 dbSNP
rs1289234408 1576 dbSNP
rs1331438519 1578 dbSNP
rs918729637 1582 dbSNP
rs1407281752 1584 dbSNP
rs1392390807 1592 dbSNP
rs981911353 1594 dbSNP
rs927797524 1599 dbSNP
rs1244308679 1601 dbSNP
rs1426475782 1604 dbSNP
rs1474692664 1604 dbSNP
rs940548172 1605 dbSNP
rs1188507166 1607 dbSNP
rs533956896 1607 dbSNP
rs1029843 1628 dbSNP
rs1475331318 1630 dbSNP
rs1029844 1634 dbSNP
rs1161896172 1635 dbSNP
rs1198673545 1639 dbSNP
rs1319353475 1642 dbSNP
rs138026251 1643 dbSNP
rs1213913034 1649 dbSNP
rs555727751 1658 dbSNP
rs1276334633 1666 dbSNP
rs1318770907 1682 dbSNP
rs1346776511 1686 dbSNP
rs1438883950 1688 dbSNP
rs1368997381 1692 dbSNP
rs1325327375 1693 dbSNP
rs1447665553 1694 dbSNP
rs1432737672 1708 dbSNP
rs141052938 1713 dbSNP
rs1169030361 1715 dbSNP
rs78380586 1716 dbSNP
rs561659475 1724 dbSNP
rs1174639442 1725 dbSNP
rs564795372 1726 dbSNP
rs1394149089 1727 dbSNP
rs902368612 1732 dbSNP
rs573122761 1734 dbSNP
rs777651735 1736 dbSNP
rs1458759626 1738 dbSNP
rs998024366 1740 dbSNP
rs999066505 1746 dbSNP
rs746083984 1747 dbSNP
rs1312436478 1749 dbSNP
rs1355259140 1753 dbSNP
rs1224027302 1754 dbSNP
rs1007307256 1771 dbSNP
rs1286727867 1772 dbSNP
rs893411062 1773 dbSNP
rs1016913695 1780 dbSNP
rs1379227842 1780 dbSNP
rs1208572807 1782 dbSNP
rs1244363589 1784 dbSNP
rs962783306 1787 dbSNP
rs1442162633 1789 dbSNP
rs758715185 1793 dbSNP
rs181759112 1794 dbSNP
rs1181875091 1798 dbSNP
rs1029845 1811 dbSNP
rs1433288224 1812 dbSNP
rs186116193 1832 dbSNP
rs768695170 1838 dbSNP
rs1441091764 1839 dbSNP
rs1405171000 1840 dbSNP
rs144671774 1842 dbSNP
rs1409805777 1847 dbSNP
rs971963249 1852 dbSNP
rs138591062 1858 dbSNP
rs1485256393 1860 dbSNP
rs927545087 1864 dbSNP
rs952027107 1866 dbSNP
rs766116681 1867 dbSNP
rs990904741 1868 dbSNP
rs910236849 1869 dbSNP
rs944420420 1877 dbSNP
rs1040091308 1880 dbSNP
rs1286532130 1883 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084040. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep1 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uacaUCCGGAAAUCUAGugaa 5'
              |||:   |:||||    
Target 5' gcugAGGUGGGUGGAUC---- 3'
8 - 24
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084040
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep1
Location of target site ENST00000317243.5 | 3UTR | AGGUGGGUGGAUCACUUGAGGUCAGGAGUUCGAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000317243.5 | 3UTR | UUGAGAGGCUGAGGUGGGUGGAUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC 0.59 0.08 0.679 0.05 7 Click to see details
UCEC -0.933 0.12 -1.000 0.5 3 Click to see details
BRCA 0.925 0.12 0.500 0.33 3 Click to see details
BLCA 0.041 0.49 -0.500 0.33 3 Click to see details
BLCA 0.041 0.49 -0.500 0.33 3 Click to see details
BLCA 0.041 0.49 -0.500 0.33 3 Click to see details
BLCA 0.041 0.49 -0.500 0.33 3 Click to see details
BLCA 0.041 0.49 -0.500 0.33 3 Click to see details
109 hsa-miR-1245a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006574 BRCA2 BRCA2, DNA repair associated 2 1
MIRT055432 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT063879 RASSF8 Ras association domain family member 8 2 6
MIRT077025 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT095775 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT099172 MAP3K4 mitogen-activated protein kinase kinase kinase 4 2 2
MIRT175616 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT456518 LYPLAL1 lysophospholipase like 1 2 2
MIRT464457 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465747 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT468257 SFXN4 sideroflexin 4 2 2
MIRT469216 RICTOR RPTOR independent companion of MTOR complex 2 2 2
MIRT472045 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT481795 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT500154 CREBBP CREB binding protein 2 2
MIRT506514 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 4
MIRT506915 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT513901 GRB10 growth factor receptor bound protein 10 2 6
MIRT519128 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT528121 FOXH1 forkhead box H1 2 2
MIRT528942 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT540580 CEP89 centrosomal protein 89 2 2
MIRT545858 ZNF264 zinc finger protein 264 2 4
MIRT547147 PGM3 phosphoglucomutase 3 2 2
MIRT547434 MED4 mediator complex subunit 4 2 2
MIRT554650 ROBO1 roundabout guidance receptor 1 2 2
MIRT558524 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT559762 ABHD5 abhydrolase domain containing 5 2 2
MIRT560438 GOLGA7B golgin A7 family member B 2 2
MIRT561974 LRRC59 leucine rich repeat containing 59 2 2
MIRT562442 DDIT4 DNA damage inducible transcript 4 2 2
MIRT563489 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT568265 BMP2K BMP2 inducible kinase 2 2
MIRT572522 KIAA0232 KIAA0232 2 2
MIRT612801 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT621533 ZNF507 zinc finger protein 507 2 2
MIRT625205 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT625615 ZNF84 zinc finger protein 84 2 2
MIRT629215 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629509 AS3MT arsenite methyltransferase 2 2
MIRT629769 STK25 serine/threonine kinase 25 2 2
MIRT630908 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT632508 RAB13 RAB13, member RAS oncogene family 2 2
MIRT636871 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT637106 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637332 FAM9B family with sequence similarity 9 member B 2 2
MIRT637553 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637639 ZNF431 zinc finger protein 431 2 2
MIRT637836 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT638326 RNF11 ring finger protein 11 2 2
MIRT638393 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT642450 CLUAP1 clusterin associated protein 1 2 2
MIRT642616 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT643133 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644324 NFKBID NFKB inhibitor delta 2 2
MIRT645150 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT645673 ADK adenosine kinase 2 2
MIRT646091 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646858 SLC35E4 solute carrier family 35 member E4 2 2
MIRT650153 ZNF426 zinc finger protein 426 2 2
MIRT652483 TMEM181 transmembrane protein 181 2 2
MIRT653790 SIRPA signal regulatory protein alpha 2 2
MIRT655526 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT657077 JPH2 junctophilin 2 2 2
MIRT657322 HOOK3 hook microtubule tethering protein 3 2 2
MIRT662036 FUT2 fucosyltransferase 2 2 2
MIRT662322 ADM2 adrenomedullin 2 2 2
MIRT663211 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663559 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663937 ZNF554 zinc finger protein 554 2 2
MIRT664689 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT664709 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT665291 ZFP14 ZFP14 zinc finger protein 2 2
MIRT665572 TXNL1 thioredoxin like 1 2 2
MIRT667068 PAOX polyamine oxidase 2 2
MIRT667304 MYO5A myosin VA 2 2
MIRT667442 METTL14 methyltransferase like 14 2 2
MIRT668048 GTPBP10 GTP binding protein 10 2 2
MIRT669604 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT671088 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT674361 SLC35E3 solute carrier family 35 member E3 2 2
MIRT674962 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT676394 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676819 AGMAT agmatinase 2 2
MIRT676891 ENSA endosulfine alpha 2 2
MIRT677059 ZNF34 zinc finger protein 34 2 2
MIRT678424 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678735 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT678930 XPOT exportin for tRNA 2 2
MIRT678954 MYADM myeloid associated differentiation marker 2 2
MIRT679228 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679765 TLR6 toll like receptor 6 2 2
MIRT681992 HRH4 histamine receptor H4 2 2
MIRT687405 NSUN4 NOP2/Sun RNA methyltransferase family member 4 2 2
MIRT694570 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT698449 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT706406 HAS2 hyaluronan synthase 2 2 2
MIRT706582 ZNF432 zinc finger protein 432 2 2
MIRT706838 VHLL VHL like 2 2
MIRT706909 DVL3 dishevelled segment polarity protein 3 2 2
MIRT707052 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT708583 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT708988 CABP4 calcium binding protein 4 2 2
MIRT713041 ADRA2B adrenoceptor alpha 2B 2 2
MIRT713731 SUCO SUN domain containing ossification factor 2 2
MIRT714968 RAB21 RAB21, member RAS oncogene family 2 2
MIRT717485 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT722826 KLK2 kallikrein related peptidase 2 2 2
MIRT723305 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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