pre-miRNA Information
pre-miRNA hsa-mir-103b-1   
Genomic Coordinates chr5: 168560904 - 168560965
Description Homo sapiens miR-103b-1 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-103b-2   
Genomic Coordinates chr20: 3917502 - 3917563
Description Homo sapiens miR-103b-2 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-103b
Sequence 1| UCAUAGCCCUGUACAAUGCUGCU |23
Evidence Experimental
Experiments ChIP-seq
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN28198041 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369221403 4 dbSNP
rs1283132774 7 dbSNP
rs1222085747 10 dbSNP
rs572980521 14 dbSNP
rs748411363 15 dbSNP
rs769854452 23 dbSNP
Putative Targets

Gene Information
Gene Symbol HSD17B12   
Synonyms KAR, SDR12C1
Description hydroxysteroid 17-beta dehydrogenase 12
Transcript NM_016142   
Expression
Putative miRNA Targets on HSD17B12
3'UTR of HSD17B12
(miRNA target sites are highlighted)
>HSD17B12|NM_016142|3'UTR
   1 GCATTGATAACTGCATTGTAACTTGGCCAGATGCTCCAGCATATGCACGTTCACTGCAAAGCACCCTACTGGTTTTGAAA
  81 ATCTGACCTTGTCATTTCAATAGTTATTAACATGACTAAATATTATCTTAATTAAGAGGAAAATAGAAGTTGCTTTTAGG
 161 GGTTTCTGACATATATTCTGGATACTATCCGAGGTAATTTTGAAGTTTAATATAAATGCTCATATCAAATGAATATAGAA
 241 CTAATATTGTCGGGAACACCTAATAGAAAGGAATACTATTATAGCAAATCACAGAATGATAGACTCAAGCATAAAACTTG
 321 GCAGTTTTATCTGCTTCAAAATGCCATTGATCATTATTCCTGTATTTTCTCTGAAACTGATTATAAAAACCAATGTCCAG
 401 CTACTCTTTTGTTTTTGACACTTGAAGAAATGGAGATCGATTTGATTTGTTTATAAGCAGACACACTGCAATTTACAAAG
 481 ATCTCTTTACGGTTTTATAAAATTATCTTCCAGTTTGTACATTTATATGGAATTGTTCTTTATCAAGGGTAGCTAATGAC
 561 ATGAAAATAATTGTGAAATATGGAATTATTTCTGACACATGAAGCCCACTAAACTATGCTTTCTTATAATGCATATTTCT
 641 TCTCAGTTTAAATGTATGTAAATATCGAAGCTATATGGTATGATTTATAAAGATAAATGGGCCAAAGTGTACATTGAGAC
 721 TGGCAGCCATCTATGGTACCACTGAAACCCTGACCCAGAAAAGTGGCTTGCTTGGACACCCAGCTGCCTTTGTTTCTGCA
 801 TTAAACCAATATTGATCACACATATGACACAGGCTAGTCCTATAAAAGTAATGACTTCATAGAAATGGCATTATAATTTT
 881 TAAGTTGATACTCTACAGGTAGCTATTGATATAATTAGTTTTAATAAAACATGCTGCAACCATGGTATACAACAAAAATA
 961 CATTTCTTTGGTGATTGAAATTAAGGCCGTATTTACAATGACTTAATATAAGACTGACTTTTATCCTGCTTCATAACTTG
1041 TATGGAGAACTCACCAAGAAAGAATTCAATACTGTGAAATATGCAGCAAGAAGATTGGTCTTTACCTAGGCTGTGTTTCC
1121 TAAGCTCTGAGTTTTCAGCACCAGTAGATTTGTATTAAAAGAAAAAAAAATGGGGCCTTAGCTTCTGGCTTTTAATTTTG
1201 CCAGCTAAGGACATAAAACAAAAATAAACAAACAAAAACAAATAGCCATCTGCTATCAGCATCATTATGTAAAAGAAAAT
1281 ATATTTTAGCCCCTAAAATTAGGAAGAATGTAATCTCAGAATAAAGGTTGTCATTTAAGTTGAATAAATATATAGCTTTA
1361 TGAAAAACACAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucGUCGUAACAUG--UCCCGAUACu 5'
            ::|: || |||  | ||||:|| 
Target 5' atTGGTCTT-TACCTA-GGCTGTGt 3'
1094 - 1116 133.00 -10.50
2
miRNA  3' ucGUCGUA-ACAUGU-CCCGAUacu 5'
            || ||| || |||  |||||   
Target 5' caCA-CATATG-ACACAGGCTAgtc 3'
817 - 839 115.00 -8.60
3
miRNA  3' ucgucGUAACAUGUCC--CGAUAcu 5'
               :| | ||||||  |||||  
Target 5' gttgaTACTCTACAGGTAGCTATtg 3'
884 - 908 110.00 -10.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30145670 78 COSMIC
COSN30171537 78 COSMIC
COSN31554819 111 COSMIC
COSN505734 163 COSMIC
COSN30130079 303 COSMIC
COSN17181619 325 COSMIC
COSN18976139 413 COSMIC
COSN20108166 413 COSMIC
COSN32062544 439 COSMIC
COSN30172050 481 COSMIC
COSN31539157 491 COSMIC
COSN30543462 553 COSMIC
COSN15804837 720 COSMIC
COSN17290300 1251 COSMIC
COSN26157499 1254 COSMIC
COSN1534902 1344 COSMIC
rs1061810 1137 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs750830046 4 dbSNP
rs753804701 13 dbSNP
rs573019251 14 dbSNP
rs11037683 16 dbSNP
rs751079549 17 dbSNP
rs754668712 25 dbSNP
rs780805754 26 dbSNP
rs1171800028 31 dbSNP
rs11037684 32 dbSNP
rs769508734 42 dbSNP
rs182511068 49 dbSNP
rs187110642 50 dbSNP
rs751153565 53 dbSNP
rs1480383833 56 dbSNP
rs753519790 57 dbSNP
rs1440988974 61 dbSNP
rs563672988 62 dbSNP
rs1380690691 67 dbSNP
rs1226060321 71 dbSNP
rs1245009693 83 dbSNP
rs191217025 85 dbSNP
rs1383214535 91 dbSNP
rs755397213 94 dbSNP
rs552336983 102 dbSNP
rs549013875 104 dbSNP
rs1372063192 112 dbSNP
rs1298255732 117 dbSNP
rs1431042668 122 dbSNP
rs887022493 126 dbSNP
rs1163471985 145 dbSNP
rs781645581 146 dbSNP
rs1272179776 148 dbSNP
rs1016997081 152 dbSNP
rs560951749 162 dbSNP
rs1418731319 164 dbSNP
rs763291488 171 dbSNP
rs1251446235 173 dbSNP
rs898175913 173 dbSNP
rs996573120 191 dbSNP
rs1289552102 192 dbSNP
rs1221619570 208 dbSNP
rs1028077572 214 dbSNP
rs111650837 221 dbSNP
rs1266983141 227 dbSNP
rs1236528321 233 dbSNP
rs748676184 239 dbSNP
rs1204082530 241 dbSNP
rs987364242 251 dbSNP
rs1031880757 252 dbSNP
rs528727998 253 dbSNP
rs1473902429 260 dbSNP
rs990447062 264 dbSNP
rs1180154284 265 dbSNP
rs528539782 266 dbSNP
rs755199252 271 dbSNP
rs1384715942 279 dbSNP
rs1450618389 283 dbSNP
rs1453440998 283 dbSNP
rs948741876 287 dbSNP
rs541334060 297 dbSNP
rs980117950 307 dbSNP
rs938802722 308 dbSNP
rs182661482 318 dbSNP
rs1335292071 319 dbSNP
rs778419070 335 dbSNP
rs1360464312 338 dbSNP
rs1203186701 340 dbSNP
rs1485403944 344 dbSNP
rs1268424887 347 dbSNP
rs1229840663 365 dbSNP
rs551633681 391 dbSNP
rs1445396914 395 dbSNP
rs1282099385 405 dbSNP
rs146635402 407 dbSNP
rs367793452 407 dbSNP
rs768994653 407 dbSNP
rs939902270 410 dbSNP
rs1038307637 411 dbSNP
rs898122097 414 dbSNP
rs996520793 425 dbSNP
rs1322869974 427 dbSNP
rs1468425732 432 dbSNP
rs1028023687 436 dbSNP
rs1230477469 437 dbSNP
rs749441064 440 dbSNP
rs1379340278 451 dbSNP
rs1190909916 460 dbSNP
rs1446272205 461 dbSNP
rs1248407318 464 dbSNP
rs1210293316 472 dbSNP
rs570535682 479 dbSNP
rs1295397174 491 dbSNP
rs1338487393 492 dbSNP
rs1200570038 504 dbSNP
rs762691130 506 dbSNP
rs187660681 543 dbSNP
rs1008003028 546 dbSNP
rs1366456277 549 dbSNP
rs550582224 563 dbSNP
rs1450834000 564 dbSNP
rs1487372611 582 dbSNP
rs569212595 590 dbSNP
rs1335055681 594 dbSNP
rs956247733 599 dbSNP
rs1012219479 610 dbSNP
rs193205496 615 dbSNP
rs1242582030 617 dbSNP
rs1390653847 627 dbSNP
rs1270527990 653 dbSNP
rs1465454459 654 dbSNP
rs1191042468 655 dbSNP
rs1388796682 658 dbSNP
rs1475376278 659 dbSNP
rs1190302880 668 dbSNP
rs969997315 674 dbSNP
rs980065321 675 dbSNP
rs752905430 677 dbSNP
rs1270264284 680 dbSNP
rs928663030 686 dbSNP
rs1343513877 687 dbSNP
rs1277333312 698 dbSNP
rs960387165 702 dbSNP
rs759637391 710 dbSNP
rs1285067630 718 dbSNP
rs1450462614 730 dbSNP
rs983567975 732 dbSNP
rs1328289271 733 dbSNP
rs1430436738 734 dbSNP
rs908347374 734 dbSNP
rs1170385492 738 dbSNP
rs1422564497 739 dbSNP
rs1384361148 752 dbSNP
rs757553876 752 dbSNP
rs1473576610 753 dbSNP
rs1038659465 755 dbSNP
rs554557084 759 dbSNP
rs1483074005 761 dbSNP
rs1254644303 762 dbSNP
rs566482460 767 dbSNP
rs908517665 771 dbSNP
rs533617306 772 dbSNP
rs1359259239 782 dbSNP
rs932592520 783 dbSNP
rs1230333503 786 dbSNP
rs1348842664 786 dbSNP
rs1279151310 789 dbSNP
rs1410562814 804 dbSNP
rs1049407709 810 dbSNP
rs558641381 813 dbSNP
rs1309835820 815 dbSNP
rs1403019569 822 dbSNP
rs1325746163 840 dbSNP
rs1437137607 844 dbSNP
rs1165232148 852 dbSNP
rs890826285 852 dbSNP
rs758525090 853 dbSNP
rs1405380898 857 dbSNP
rs1157916228 861 dbSNP
rs1472666264 868 dbSNP
rs1413527453 871 dbSNP
rs970956242 885 dbSNP
rs1052893358 886 dbSNP
rs891921395 907 dbSNP
rs1221907205 910 dbSNP
rs1224283421 919 dbSNP
rs1011755670 920 dbSNP
rs578099036 929 dbSNP
rs1229226253 931 dbSNP
rs1331389481 932 dbSNP
rs545624373 943 dbSNP
rs1259778429 947 dbSNP
rs1446877168 948 dbSNP
rs1021782625 975 dbSNP
rs1343191667 976 dbSNP
rs557230073 989 dbSNP
rs549385406 990 dbSNP
rs1001770246 997 dbSNP
rs1413638814 1009 dbSNP
rs1173660644 1019 dbSNP
rs11555763 1020 dbSNP
rs1426530811 1032 dbSNP
rs11555765 1041 dbSNP
rs542925576 1042 dbSNP
rs1241890452 1058 dbSNP
rs1209683002 1060 dbSNP
rs1198217945 1066 dbSNP
rs1412172612 1070 dbSNP
rs1261445460 1083 dbSNP
rs1203148829 1092 dbSNP
rs1312816205 1095 dbSNP
rs960085110 1096 dbSNP
rs983901267 1101 dbSNP
rs1359696025 1113 dbSNP
rs1061810 1137 dbSNP
rs144353338 1138 dbSNP
rs1182285910 1145 dbSNP
rs555290841 1148 dbSNP
rs1334247653 1153 dbSNP
rs1465148428 1155 dbSNP
rs1405855068 1157 dbSNP
rs1359218565 1158 dbSNP
rs919779315 1162 dbSNP
rs973896924 1162 dbSNP
rs1189640029 1175 dbSNP
rs1451676063 1194 dbSNP
rs1325526017 1196 dbSNP
rs1181476088 1197 dbSNP
rs1483653303 1210 dbSNP
rs932545345 1212 dbSNP
rs1329125431 1221 dbSNP
rs1404046184 1226 dbSNP
rs1305715349 1227 dbSNP
rs1288756024 1231 dbSNP
rs1228915821 1233 dbSNP
rs1367062541 1234 dbSNP
rs540343616 1235 dbSNP
rs565415301 1249 dbSNP
rs1395083962 1255 dbSNP
rs1230486111 1261 dbSNP
rs1259015745 1265 dbSNP
rs1379364917 1269 dbSNP
rs1304096448 1275 dbSNP
rs1350095584 1294 dbSNP
rs1210950938 1302 dbSNP
rs1292708224 1328 dbSNP
rs1432069202 1340 dbSNP
rs1383759719 1342 dbSNP
rs1164437699 1343 dbSNP
rs1424628959 1343 dbSNP
rs1490006034 1351 dbSNP
rs1258469132 1352 dbSNP
rs1175585672 1353 dbSNP
rs1482750389 1361 dbSNP
rs944381882 1364 dbSNP
rs1205764169 1365 dbSNP
rs1253019421 1368 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ucGUCGUAAC---AUGUCCCGAUACu 5'
            || || ||   | || | ||: | 
Target 5' cgCACCACUGCACUCCA-GCCUGGGc 3'
5 - 29
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000278353.4 | 3UTR | UGAUCGCACCACUGCACUCCAGCCUGGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.682 5.1e-3 0.753 1.5e-3 13 Click to see details
GSE28544 Breast cancer -0.252 1.2e-1 -0.332 5.6e-2 24 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
53 hsa-miR-103b Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT218386 E2F3 E2F transcription factor 3 2 2
MIRT404221 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT441502 SPG20 spartin 2 6
MIRT444124 ZNRF3 zinc and ring finger 3 2 2
MIRT454236 OSBPL10 oxysterol binding protein like 10 2 4
MIRT457919 ZNF212 zinc finger protein 212 2 2
MIRT462254 LAMA4 laminin subunit alpha 4 2 2
MIRT463176 ZNF281 zinc finger protein 281 2 2
MIRT472355 TSPAN1 tetraspanin 1 2 2
MIRT474133 LIN54 lin-54 DREAM MuvB core complex component 2 4
MIRT494946 IFFO2 intermediate filament family orphan 2 2 2
MIRT497403 NPY4R neuropeptide Y receptor Y4 2 2
MIRT497641 GLDN gliomedin 2 2
MIRT505340 TMEM245 transmembrane protein 245 2 6
MIRT505680 SESTD1 SEC14 and spectrin domain containing 1 2 6
MIRT510706 SREK1IP1 SREK1 interacting protein 1 2 6
MIRT512198 C1orf43 chromosome 1 open reading frame 43 2 2
MIRT522089 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT525074 FRK fyn related Src family tyrosine kinase 2 2
MIRT531276 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT535119 PLXNA2 plexin A2 2 2
MIRT540836 GNAT1 G protein subunit alpha transducin 1 2 4
MIRT541018 WIPI2 WD repeat domain, phosphoinositide interacting 2 2 2
MIRT545752 CA12 carbonic anhydrase 12 2 4
MIRT546404 SRP9 signal recognition particle 9 2 2
MIRT547991 HCFC2 host cell factor C2 2 4
MIRT554502 SAE1 SUMO1 activating enzyme subunit 1 2 2
MIRT558360 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT558863 CD2AP CD2 associated protein 2 2
MIRT559939 ZNF567 zinc finger protein 567 2 2
MIRT566300 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT567490 FOXK1 forkhead box K1 2 2
MIRT617139 ZNF556 zinc finger protein 556 2 2
MIRT625400 AKR7L aldo-keto reductase family 7 like (gene/pseudogene) 2 2
MIRT626491 CEP89 centrosomal protein 89 2 2
MIRT629487 GSN gelsolin 2 4
MIRT638456 PLXDC2 plexin domain containing 2 2 2
MIRT648498 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT654845 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT664587 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT664977 TDRD1 tudor domain containing 1 2 2
MIRT665028 ELK1 ELK1, ETS transcription factor 2 2
MIRT666043 STON2 stonin 2 2 2
MIRT668863 CRY2 cryptochrome circadian clock 2 2 2
MIRT669297 C17orf85 nuclear cap binding subunit 3 2 2
MIRT680975 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT682267 RS1 retinoschisin 1 2 2
MIRT685283 KIAA1143 KIAA1143 2 2
MIRT693375 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT701785 MSL1 male specific lethal 1 homolog 2 2
MIRT709373 SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 2 2
MIRT715154 IL12B interleukin 12B 2 2
MIRT734499 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-miR-103b Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-103b Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-103b Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)

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