pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SF3A1   
Synonyms PRP21, PRPF21, SAP114, SF3A120
Description splicing factor 3a subunit 1
Transcript NM_005877   
Expression
Putative miRNA Targets on SF3A1
3'UTR of SF3A1
(miRNA target sites are highlighted)
>SF3A1|NM_005877|3'UTR
   1 ACAAGAGGAACCTGCTGTCAAGTCCCTGCCATTTTGCCTCTCCTGTCTCCCACCCCCTGCCCCAGACCCAGGAGCCCCCC
  81 TGAGGCTTTGCCTTGCCTGCATATTTGTTTCGCTCTTACTCAGTTTGGGAATTCAAATTGTCCTGCAGAGGTTCATTCCC
 161 CTGACCCTTTCCCCACATTGGTAAGAGTAGCTGGGTTTTCTAAGCCACTCTCTGGAATCTCTTTGTGTTAGGGTCTCGAT
 241 TTGAGGACATTCATTTCTTCAGCAGCCCATTAGCAACTGAGAGCCCAGGGATGTCCTACAGGATAGTTTCATAGTGACAG
 321 GTGGCACTTGGCTAATAGAATATGGCTGATATTGTCATTAATCATTTTGTACCTTGACATGGGTTGTCTAATAAAACTCG
 401 GACCCTTCTTGTGAAATCAGTTAAATAAGACTTGTCTCGGTCACCTGTGCCCTGTCCAGACTCGAGGCAGTGGTAACACT
 481 GCACAGTGCTATGTGGCTTCTCTTTGAGGATTTTTGGGTTTTGTAACTAAATTCTTGCTGCCCTCATACTTTTTATGTAT
 561 TAGAATCATATTCGTATTGCCCTTTTAAAACATTGGGATCCTCCAAAGGCCTGCCCCATGTATTTAACAGTAATACAGGA
 641 AGCATGGCAGGCACCATGCAAACCAAGGATGGATGGTGCAGTCCCTGTGTCAGTGGGCGGTGGTTTCCTGCTGGCCTGGA
 721 ATCACTCATCACCTGATTGATTGGCTCTGTGGTCCTGGGCAGGTGCCTCATAGGTGTGTGGATATGATGACGTTTCTTTA
 801 AAATGTATGTATTTAACAAATACTTAATTGTATTAAGGTCATGTACCAAGGATTTGATAAAGTTTAAATAATTTACTCTC
 881 TACTTTTATCCATTTTATCCATTTTAACTCATGTAATCCTCATGTGAGTATTCCTGTTTAACACTTGAGTAAACTGAGGC
 961 ACAGAGAACATAAGTTGCATGCCATAGTCACACACTGTGAAAGTGAAAAGAGAATGTGTGCAAAACACGTCACAGTCCTG
1041 GTTTCTGAGTAAAGGCAGGCTGTTATCTTTAGAATCAAGCTATCACAGGGAGATAGGCAATGCTGTGGGTGTTGGAGGAA
1121 GGTGAGAGCCTGTTGCTAACAATTTCCTGGTTTTAAAGCTAAGGCTGATTTTATTGGGAAGATCTCACATGTGTGTGGCC
1201 CCTGAGAGTTCCCAGTGCCTTTTATTTGCAGTCCTTCCATTTGGACCTCCTAGCTGCCCCATCAGGTCATCTCCAGGGCT
1281 CAGAGGGGTGAGACCATTTCCCAAGGTCACAGAACCAGCTCTCTAGTCACCACCCTGCCTCTCCCTCTCACCCAGAGTCA
1361 GTACCAGTTTTATGGCTTTATTACAAACTGCTGGGTCCCTCCCATTTTCAACTTGATTGATGGGATGTCATCCCTTATCC
1441 TGTCTGACATTTGCCTCTGGCCTGGTTGCTAGAAGTTTGCCCCAGGGGCAAGAGTTGAAATTTGGCTTCCTGAGGTGGGC
1521 TTTGTGGTTTGCGTCCCTAAAGTGAGCCCACTACTGGTTGCTTGTCCATGGCCAACACCAGAAATCCCCTGAGCACTACC
1601 TGGGTCTCATTCCAAGAAGGAAGAGGGTCAGGAGACCTGGGGAGTCTCATATTCCAAGTTCTTCTTTCTTTCTGGGAGCA
1681 GTGGGCAGTTCATGGTGTTAGGGCACTCACCCCCACAGACTGGCAAACCCTGCAGGACTTCCGTGGCTGAGGCTGTGACC
1761 GGAGGCCAGGAATGCCGTTGGGTGGATTGTGAGTGAATGGGCCCTTTGAGCTGCCCTCTAGAGAGCAAATCCAGTTTCCT
1841 GGAGCTCCTGAATGAATATCTGTACTGGCTCGCTCAGATGCAGAAGCTCCATTGACCATGAGGCCTTGTGAACATCAGTG
1921 GCCACAGGCCCAGTGTGCTGCTTGGCACTGCACTAGTTTAGGACCTGCAGCATGTAGGTAGCGTCCTAGTGTTTATAATA
2001 CAAAGCTGCTCTGCACAGCTTTTCTGATTCTTCTTGCAATCTCCTGAGGATTATCTGCCCCATTTTTAAAACGAGGTGGA
2081 ATACCCAAGGTCATGTAGCCAGTGAGTGCTCTGGAAAGCCAAAGCAGCTCATCCCTTCCTGGGGACCACACTGCTCTGCT
2161 CCACCAGACCACACTATGAAATAGGAATAAGTGCTCCTGTTGCAGGACTGCTGGGAAAACAGGTGGTGTGGGACTTAAGT
2241 CACCATAATTTTGAAGACTTGCATGCAGAGGGCTCCAGGAATTGTAGACATTAAGGAATTTCACTTTCAGTTCTACCCAC
2321 TACTTAAGTACTTGTCATGTACTCTTAGAGGAGGCCAGTAATGATCAGAACCATTTTACTTTAAAATTAATAATATTGTA
2401 TTAGAGAATATATTAAATGGTTATATTGGGTTATGTTAGGATATATACTTGAATGGAAATACATGTACTATTAGCAATCA
2481 TATTTCATTTATCCCTGTAATTAGACAAGAAAGCATAATATAGCTCTACTCATGGGTACACATACCAGTGTATAAGATTT
2561 TTAGAAGTTTACTTTTTAAAAATAAAAGCAAAATGTAAGATCTTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acgGUCGGAGCGGGUCg 5'
             | | |||||:||| 
Target 5' gtaCTGGCTCGCTCAGa 3'
1862 - 1878 138.00 -19.00
2
miRNA  3' acggucggagCGGGUCg 5'
                    |||||| 
Target 5' gcaactgagaGCCCAGg 3'
273 - 289 120.00 -11.60
3
miRNA  3' acgguCGGAGCGGGUCg 5'
               ||| :|:|||| 
Target 5' cctgtGCCCTGTCCAGa 3'
444 - 460 120.00 -17.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30498258 38 COSMIC
COSN26994427 60 COSMIC
COSN30166210 74 COSMIC
COSN30154654 185 COSMIC
COSN15727197 342 COSMIC
COSN21961327 517 COSMIC
COSN26592707 592 COSMIC
COSN16367857 807 COSMIC
COSN23636124 842 COSMIC
COSN9164014 1383 COSMIC
COSN6423097 1820 COSMIC
COSN19117329 1872 COSMIC
COSN8009755 1957 COSMIC
COSN9164013 2199 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs749964922 1 dbSNP
rs1396397107 5 dbSNP
rs201154972 11 dbSNP
rs761786172 12 dbSNP
rs1440077551 14 dbSNP
rs1251818469 19 dbSNP
rs1200256571 22 dbSNP
rs751483682 23 dbSNP
rs1321931449 29 dbSNP
rs763862103 37 dbSNP
rs762810591 38 dbSNP
rs76936529 42 dbSNP
rs770076729 45 dbSNP
rs1322050371 47 dbSNP
rs375301118 51 dbSNP
rs887752848 55 dbSNP
rs1305665080 56 dbSNP
rs1341782275 63 dbSNP
rs1032018193 67 dbSNP
rs1390759797 69 dbSNP
rs1400670314 70 dbSNP
rs751572592 74 dbSNP
rs1269520573 76 dbSNP
rs1002025605 78 dbSNP
rs1467723150 79 dbSNP
rs1213952883 81 dbSNP
rs1417473521 95 dbSNP
rs764012148 97 dbSNP
rs543715750 100 dbSNP
rs905031226 101 dbSNP
rs1161790713 105 dbSNP
rs1040544020 107 dbSNP
rs1231272801 109 dbSNP
rs1328185736 111 dbSNP
rs1046327976 112 dbSNP
rs1381711261 113 dbSNP
rs1013471210 131 dbSNP
rs1319124247 132 dbSNP
rs1438968887 136 dbSNP
rs943501522 139 dbSNP
rs887007230 147 dbSNP
rs1291159473 154 dbSNP
rs556869720 155 dbSNP
rs762775050 165 dbSNP
rs1233448179 166 dbSNP
rs1274658100 171 dbSNP
rs1047508654 180 dbSNP
rs1466838264 194 dbSNP
rs1180849689 199 dbSNP
rs1045784 200 dbSNP
rs1204011178 202 dbSNP
rs775287755 206 dbSNP
rs1228558434 208 dbSNP
rs148941306 210 dbSNP
rs769539684 212 dbSNP
rs1186072414 213 dbSNP
rs1039809437 222 dbSNP
rs1475739165 225 dbSNP
rs1277267774 236 dbSNP
rs759809914 237 dbSNP
rs1453373861 238 dbSNP
rs1238233725 241 dbSNP
rs1387264536 244 dbSNP
rs1411612947 249 dbSNP
rs776661122 252 dbSNP
rs1354814216 253 dbSNP
rs3171603 257 dbSNP
rs543088935 260 dbSNP
rs771104580 263 dbSNP
rs1314730629 266 dbSNP
rs1237914462 276 dbSNP
rs1260751436 279 dbSNP
rs867080914 281 dbSNP
rs1352229888 299 dbSNP
rs924955315 302 dbSNP
rs978191917 314 dbSNP
rs1393494166 317 dbSNP
rs747059189 323 dbSNP
rs986937302 327 dbSNP
rs1190479173 335 dbSNP
rs1248905134 347 dbSNP
rs1418675117 352 dbSNP
rs1160127916 356 dbSNP
rs368115921 374 dbSNP
rs569436772 384 dbSNP
rs917868530 388 dbSNP
rs572563820 400 dbSNP
rs554250167 401 dbSNP
rs988220144 402 dbSNP
rs959162322 404 dbSNP
rs1435307598 411 dbSNP
rs957720027 413 dbSNP
rs1370932718 417 dbSNP
rs538809779 418 dbSNP
rs1032089893 419 dbSNP
rs1307262183 425 dbSNP
rs867676045 431 dbSNP
rs373966755 434 dbSNP
rs145711744 438 dbSNP
rs984854307 439 dbSNP
rs1178207602 440 dbSNP
rs1382747543 443 dbSNP
rs1192345411 449 dbSNP
rs1013382875 456 dbSNP
rs1252910818 457 dbSNP
rs1452860178 458 dbSNP
rs748614878 463 dbSNP
rs1026305815 464 dbSNP
rs1046970430 470 dbSNP
rs1435204102 477 dbSNP
rs1178152377 481 dbSNP
rs901845885 504 dbSNP
rs995953859 505 dbSNP
rs1019581407 515 dbSNP
rs1461288680 534 dbSNP
rs898482369 540 dbSNP
rs1481843738 545 dbSNP
rs1007779236 551 dbSNP
rs1453037355 552 dbSNP
rs1281502462 559 dbSNP
rs889259826 568 dbSNP
rs779448031 570 dbSNP
rs1054576693 573 dbSNP
rs538136146 574 dbSNP
rs552466013 578 dbSNP
rs118168076 585 dbSNP
rs912625376 586 dbSNP
rs1051265775 594 dbSNP
rs1042055530 596 dbSNP
rs946201221 605 dbSNP
rs750103357 620 dbSNP
rs1253488519 621 dbSNP
rs1467278640 626 dbSNP
rs913507878 630 dbSNP
rs990412865 635 dbSNP
rs957965427 641 dbSNP
rs1455642156 644 dbSNP
rs1184922237 651 dbSNP
rs1417274000 653 dbSNP
rs1427892125 654 dbSNP
rs924964438 656 dbSNP
rs1369896033 669 dbSNP
rs1170838253 670 dbSNP
rs1425541323 675 dbSNP
rs547782060 678 dbSNP
rs969112627 687 dbSNP
rs535853257 698 dbSNP
rs1394851375 719 dbSNP
rs992438012 725 dbSNP
rs951246145 726 dbSNP
rs1286660798 735 dbSNP
rs1361830186 744 dbSNP
rs1215701313 745 dbSNP
rs565388563 747 dbSNP
rs780692804 748 dbSNP
rs1298119358 750 dbSNP
rs995425099 752 dbSNP
rs898385237 755 dbSNP
rs1056370811 769 dbSNP
rs937932912 770 dbSNP
rs758378517 776 dbSNP
rs547489305 782 dbSNP
rs1006854413 789 dbSNP
rs865842372 791 dbSNP
rs756858931 792 dbSNP
rs1187056353 807 dbSNP
rs118010891 809 dbSNP
rs972182393 827 dbSNP
rs891943669 840 dbSNP
rs1418097034 841 dbSNP
rs966412918 841 dbSNP
rs1156261387 843 dbSNP
rs1055143282 844 dbSNP
rs2108094 845 dbSNP
rs1018966169 846 dbSNP
rs1007748256 857 dbSNP
rs565075096 862 dbSNP
rs115826798 865 dbSNP
rs1192062045 867 dbSNP
rs1488302842 872 dbSNP
rs927511808 876 dbSNP
rs1287555393 878 dbSNP
rs1300587475 895 dbSNP
rs1208637732 906 dbSNP
rs1354181361 907 dbSNP
rs760433777 910 dbSNP
rs1414535846 917 dbSNP
rs1000361607 920 dbSNP
rs531633627 921 dbSNP
rs775231678 922 dbSNP
rs1222307572 924 dbSNP
rs188022198 928 dbSNP
rs1220779065 935 dbSNP
rs1009335154 939 dbSNP
rs1359649879 947 dbSNP
rs1265232948 959 dbSNP
rs1484679244 962 dbSNP
rs1186920547 963 dbSNP
rs182558122 966 dbSNP
rs1056169468 968 dbSNP
rs1175132749 970 dbSNP
rs1406517737 974 dbSNP
rs1400774306 979 dbSNP
rs991906557 981 dbSNP
rs868547865 982 dbSNP
rs1374149891 983 dbSNP
rs926566066 995 dbSNP
rs763546602 996 dbSNP
rs1342655295 999 dbSNP
rs1342378680 1000 dbSNP
rs1440213962 1000 dbSNP
rs1311207840 1007 dbSNP
rs1049005348 1013 dbSNP
rs1374406846 1014 dbSNP
rs930506288 1014 dbSNP
rs1278337395 1015 dbSNP
rs1210102334 1026 dbSNP
rs1434626107 1028 dbSNP
rs1360295523 1029 dbSNP
rs919084228 1032 dbSNP
rs116412817 1034 dbSNP
rs1419278356 1036 dbSNP
rs1179934012 1037 dbSNP
rs1169441808 1040 dbSNP
rs762910174 1049 dbSNP
rs962621569 1054 dbSNP
rs1264692095 1057 dbSNP
rs1244663696 1063 dbSNP
rs112624788 1065 dbSNP
rs1405066746 1066 dbSNP
rs114359185 1074 dbSNP
rs2839998 1076 dbSNP
rs891129132 1085 dbSNP
rs765031436 1089 dbSNP
rs759241019 1090 dbSNP
rs978972712 1094 dbSNP
rs776981570 1095 dbSNP
rs1054632855 1142 dbSNP
rs371401061 1145 dbSNP
rs1272070776 1150 dbSNP
rs1438000442 1160 dbSNP
rs896204535 1161 dbSNP
rs1219479575 1163 dbSNP
rs376784304 1164 dbSNP
rs556697317 1174 dbSNP
rs947748422 1187 dbSNP
rs56184734 1189 dbSNP
rs1414283629 1190 dbSNP
rs1379856862 1191 dbSNP
rs992207663 1193 dbSNP
rs1380017240 1199 dbSNP
rs929758410 1200 dbSNP
rs918289374 1205 dbSNP
rs1420694803 1208 dbSNP
rs973940503 1215 dbSNP
rs1324137515 1221 dbSNP
rs573953129 1229 dbSNP
rs911179809 1233 dbSNP
rs1441710224 1252 dbSNP
rs760861689 1261 dbSNP
rs1325663439 1265 dbSNP
rs150182853 1272 dbSNP
rs1269320735 1274 dbSNP
rs955387506 1276 dbSNP
rs1465801099 1278 dbSNP
rs1318345746 1279 dbSNP
rs1029676343 1287 dbSNP
rs1220313358 1290 dbSNP
rs897671424 1304 dbSNP
rs535815507 1305 dbSNP
rs773444934 1306 dbSNP
rs1333766820 1316 dbSNP
rs1036167384 1321 dbSNP
rs1010614257 1323 dbSNP
rs911936578 1325 dbSNP
rs772233697 1331 dbSNP
rs374219757 1343 dbSNP
rs1033504296 1345 dbSNP
rs1163292704 1348 dbSNP
rs1422684142 1349 dbSNP
rs1413910064 1351 dbSNP
rs1417385426 1365 dbSNP
rs1462198447 1372 dbSNP
rs1165033837 1380 dbSNP
rs1183460896 1383 dbSNP
rs1000360049 1402 dbSNP
rs906023902 1411 dbSNP
rs1044658967 1418 dbSNP
rs1014475299 1429 dbSNP
rs59653506 1430 dbSNP
rs1401593927 1433 dbSNP
rs1291253856 1434 dbSNP
rs1333656417 1436 dbSNP
rs925940101 1438 dbSNP
rs979444828 1442 dbSNP
rs1347928304 1445 dbSNP
rs1056133041 1451 dbSNP
rs1287354208 1453 dbSNP
rs1459231639 1460 dbSNP
rs1020881260 1480 dbSNP
rs992972716 1490 dbSNP
rs929595449 1493 dbSNP
rs1189887003 1494 dbSNP
rs1362350671 1503 dbSNP
rs1453134124 1509 dbSNP
rs1034801677 1521 dbSNP
rs1361055027 1532 dbSNP
rs918375255 1533 dbSNP
rs1310798279 1535 dbSNP
rs1232922031 1536 dbSNP
rs1314425627 1537 dbSNP
rs1333680699 1538 dbSNP
rs547110926 1539 dbSNP
rs1237669991 1550 dbSNP
rs538704543 1565 dbSNP
rs1038122562 1569 dbSNP
rs1356416074 1571 dbSNP
rs1322344078 1576 dbSNP
rs1001941194 1578 dbSNP
rs904882778 1580 dbSNP
rs571300083 1587 dbSNP
rs1418763173 1589 dbSNP
rs1179293340 1603 dbSNP
rs1222558270 1608 dbSNP
rs995175485 1612 dbSNP
rs1373311906 1615 dbSNP
rs549990006 1620 dbSNP
rs897705740 1622 dbSNP
rs531545414 1624 dbSNP
rs567521319 1633 dbSNP
rs1304423221 1637 dbSNP
rs779501451 1646 dbSNP
rs1332426696 1654 dbSNP
rs1393826951 1655 dbSNP
rs1390489963 1661 dbSNP
rs773990651 1667 dbSNP
rs1378485726 1672 dbSNP
rs1231533064 1673 dbSNP
rs1392767221 1674 dbSNP
rs944593030 1674 dbSNP
rs1313348051 1676 dbSNP
rs1235850982 1685 dbSNP
rs985262451 1687 dbSNP
rs955321348 1689 dbSNP
rs1480404136 1692 dbSNP
rs1323412790 1696 dbSNP
rs5753073 1699 dbSNP
rs12169570 1701 dbSNP
rs1349956421 1706 dbSNP
rs1193148070 1708 dbSNP
rs1424343829 1714 dbSNP
rs749609163 1730 dbSNP
rs527652149 1741 dbSNP
rs1050497642 1742 dbSNP
rs9606717 1743 dbSNP
rs1379655004 1746 dbSNP
rs1179208604 1749 dbSNP
rs1000224841 1760 dbSNP
rs756837348 1761 dbSNP
rs551060860 1764 dbSNP
rs1488967102 1766 dbSNP
rs533465879 1767 dbSNP
rs777270226 1768 dbSNP
rs77926917 1776 dbSNP
rs927426843 1777 dbSNP
rs896075556 1781 dbSNP
rs1260217293 1787 dbSNP
rs752690769 1802 dbSNP
rs969096908 1811 dbSNP
rs1369155716 1820 dbSNP
rs1247396375 1834 dbSNP
rs1303221954 1843 dbSNP
rs1048438177 1844 dbSNP
rs1192862246 1852 dbSNP
rs993886632 1858 dbSNP
rs1477366473 1862 dbSNP
rs1171189648 1865 dbSNP
rs1385865775 1870 dbSNP
rs896795508 1871 dbSNP
rs951928713 1872 dbSNP
rs962009948 1879 dbSNP
rs866925817 1898 dbSNP
rs1008752841 1924 dbSNP
rs1361935492 1939 dbSNP
rs765084985 1947 dbSNP
rs1280530751 1952 dbSNP
rs1353753692 1967 dbSNP
rs890308705 1968 dbSNP
rs1290610868 1974 dbSNP
rs910950196 1976 dbSNP
rs1050189544 1977 dbSNP
rs996226649 1980 dbSNP
rs1049596907 1982 dbSNP
rs933810936 1983 dbSNP
rs754844290 1986 dbSNP
rs562728745 1988 dbSNP
rs1197976339 1990 dbSNP
rs1473990418 2008 dbSNP
rs1180932625 2012 dbSNP
rs781434829 2016 dbSNP
rs1433954726 2027 dbSNP
rs537299666 2034 dbSNP
rs185295318 2039 dbSNP
rs1269689804 2043 dbSNP
rs922585085 2054 dbSNP
rs1156372670 2057 dbSNP
rs913211670 2062 dbSNP
rs1300384578 2072 dbSNP
rs1286837816 2086 dbSNP
rs1374041399 2090 dbSNP
rs1447487649 2091 dbSNP
rs1219433356 2093 dbSNP
rs1346418432 2099 dbSNP
rs989117072 2109 dbSNP
rs555602800 2111 dbSNP
rs1352832916 2115 dbSNP
rs925971214 2125 dbSNP
rs9606716 2130 dbSNP
rs1484566556 2131 dbSNP
rs970116802 2133 dbSNP
rs980231804 2136 dbSNP
rs1237669590 2139 dbSNP
rs751696709 2144 dbSNP
rs1473595703 2147 dbSNP
rs527721939 2152 dbSNP
rs920394574 2156 dbSNP
rs1339192906 2158 dbSNP
rs992988847 2174 dbSNP
rs1298347920 2176 dbSNP
rs1160977792 2178 dbSNP
rs766152156 2182 dbSNP
rs1026589414 2185 dbSNP
rs140401298 2189 dbSNP
rs1171959425 2191 dbSNP
rs553725300 2193 dbSNP
rs1335323859 2196 dbSNP
rs1361072468 2197 dbSNP
rs1330697798 2199 dbSNP
rs961763731 2199 dbSNP
rs1062349 2215 dbSNP
rs10376 2227 dbSNP
rs1168524785 2228 dbSNP
rs560460311 2238 dbSNP
rs1311356898 2246 dbSNP
rs954595950 2263 dbSNP
rs118096913 2270 dbSNP
rs1005188994 2284 dbSNP
rs761969590 2286 dbSNP
rs1201549150 2287 dbSNP
rs1236961888 2289 dbSNP
rs1457817714 2302 dbSNP
rs1180030883 2305 dbSNP
rs34428744 2308 dbSNP
rs556297986 2310 dbSNP
rs1478006852 2318 dbSNP
rs1043176622 2320 dbSNP
rs1374266952 2326 dbSNP
rs1299973540 2341 dbSNP
rs933863710 2352 dbSNP
rs538012300 2353 dbSNP
rs900990575 2360 dbSNP
rs775063691 2377 dbSNP
rs938922138 2379 dbSNP
rs567484463 2390 dbSNP
rs1316984020 2391 dbSNP
rs927488965 2393 dbSNP
rs1275161284 2396 dbSNP
rs1278252962 2400 dbSNP
rs934593766 2403 dbSNP
rs1044664233 2411 dbSNP
rs1257014579 2419 dbSNP
rs1318202822 2420 dbSNP
rs774596404 2439 dbSNP
rs925835405 2444 dbSNP
rs750854523 2446 dbSNP
rs978737553 2451 dbSNP
rs1200211220 2454 dbSNP
rs1249038515 2462 dbSNP
rs182927015 2463 dbSNP
rs190380548 2468 dbSNP
rs1193462097 2470 dbSNP
rs1424562439 2470 dbSNP
rs1279902111 2477 dbSNP
rs1467407641 2481 dbSNP
rs1162815027 2482 dbSNP
rs973197654 2489 dbSNP
rs769013026 2491 dbSNP
rs116961604 2495 dbSNP
rs1404628252 2506 dbSNP
rs940409451 2521 dbSNP
rs1333366559 2529 dbSNP
rs993301220 2531 dbSNP
rs1397885841 2532 dbSNP
rs566702020 2539 dbSNP
rs1277364662 2546 dbSNP
rs960262702 2558 dbSNP
rs1340696938 2564 dbSNP
rs1220103372 2572 dbSNP
rs74278067 2584 dbSNP
rs1404083793 2588 dbSNP
rs1263097008 2589 dbSNP
rs1296297613 2605 dbSNP
rs987059839 2607 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293/HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1067869. RNA binding protein: AGO2. Condition:Ago2 IP-seq (asynchronous cells) ...

- Kishore S; Gruber AR; Jedlinski DJ; Syed et al., 2013, Genome biology.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acggucGGAGCGGGUCg 5'
                ::|||||||| 
Target 5' uugcucUUUCGCCCAGg 3'
2 - 18
Article - Kishore S; Gruber AR; Jedlinski DJ; Syed et al.
- Genome biology, 2013
BACKGROUND: In recent years, a variety of small RNAs derived from other RNAs with well-known functions such as tRNAs and snoRNAs, have been identified. The functional relevance of these RNAs is largely unknown. To gain insight into the complexity of snoRNA processing and the functional relevance of snoRNA-derived small RNAs, we sequence long and short RNAs, small RNAs that co-precipitate with the Argonaute 2 protein and RNA fragments obtained in photoreactive nucleotide-enhanced crosslinking and immunoprecipitation (PAR-CLIP) of core snoRNA-associated proteins. RESULTS: Analysis of these data sets reveals that many loci in the human genome reproducibly give rise to C/D box-like snoRNAs, whose expression and evolutionary conservation are typically less pronounced relative to the snoRNAs that are currently cataloged. We further find that virtually all C/D box snoRNAs are specifically processed inside the regions of terminal complementarity, retaining in the mature form only 4-5 nucleotides upstream of the C box and 2-5 nucleotides downstream of the D box. Sequencing of the total and Argonaute 2-associated populations of small RNAs reveals that despite their cellular abundance, C/D box-derived small RNAs are not efficiently incorporated into the Ago2 protein. CONCLUSIONS: We conclude that the human genome encodes a large number of snoRNAs that are processed along the canonical pathway and expressed at relatively low levels. Generation of snoRNA-derived processing products with alternative, particularly miRNA-like, functions appears to be uncommon.
LinkOut: [PMID: 23706177]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acggucGGAGCGGGUCg 5'
                ::|||||||| 
Target 5' ------UUUCGCCCAGg 3'
1 - 11
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1067869
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293/HeLa / Ago2 IP-seq (asynchronous cells)
Location of target site ENST00000215793.8 | 3UTR | CUUGCUCUUUCGCCCAGGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23706177 / GSE43666
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000215793.8 | 3UTR | UUUCGCCCAGGCUGGAGUGCAGUGGCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

Error report submission