pre-miRNA Information
pre-miRNA hsa-mir-452   
Genomic Coordinates chrX: 151959628 - 151959712
Synonyms MIRN452, hsa-mir-452, MIR452
Description Homo sapiens miR-452 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-452-3p
Sequence 58| CUCAUCUGCAAAGAAGUAAGUG |79
Evidence Experimental
Experiments Array-cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 X - 151959644 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757928550 3 dbSNP
rs1324216965 6 dbSNP
rs1390793899 13 dbSNP
rs899383242 17 dbSNP
rs747858567 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SLC22A3   
Synonyms EMT, EMTH, OCT3
Description solute carrier family 22 member 3
Transcript NM_021977   
Expression
Putative miRNA Targets on SLC22A3
3'UTR of SLC22A3
(miRNA target sites are highlighted)
>SLC22A3|NM_021977|3'UTR
   1 GGCCCCCGACAAAGACAGAAAGAAGGAGCTATCCAGGAGCTGATCCTCCTTGCAAAGCTGTGCCTTGCAGAGATGCACGT
  81 GTGCATTTCAGCTACATCATGCCGCGCTGTTGTAATACTGTATAAAGACCTCAATCTATCCAGAGTATTTTTATATAATG
 161 TTGGATGAGTTAGGATTTGTAATGCTGTTGAAGTTTCTGGGAACACATAATATGTAGCCAGTTTAACAAAGAAGCTGTCA
 241 GGTGCACAGCCCTTCCTGGGTTTTTTTCTTGTGTTCCCTGTGGTCTCTGACCCATTAGGCTAAAGAGAGACAAGAGAAGC
 321 CCCCAACCTGATTCTCATGACAGCTCCATCAAGAATGTGGGATGTGCCGACCAAGGATTTGAGAAAGTTGTACAGAAATG
 401 TGTTCATCAAATCTGGTCAAGGGACTAAGCTCCTAGCTGACCATTCATTCTGAAGATTGCATGGAGGATGAACATCTGGG
 481 AATCCTGTTAATGAGAAGGCTGAATCACAGGCACCTGGGCCAAAGGGTGTGAGCATTCATGTTCTCTGCTCACCTTGGTT
 561 TCCGCACACCTTCGCAATGTGAACAGGTCAGGAGTCCCTCCCGTCCACCTCCTCTGTAACAGCTGGGGTTCCAGGCATGG
 641 TTTAGGCCCTGTTCCAGCAATAAGAACCAATCTGCTGTACAATCTGAGGACTTGGCTCTGTTATTTACAAAATGATGCTG
 721 TGGTTCTGAGATTATTTGGGACATTTTTGGCTCTCCTTTAGTGGACACCTAGAGCCACAGATTCCCTTCTTTACTAAACA
 801 AATCCCATGGATTCTGATTTCTGGGTCTTAGGATTTTAAAAGTGAAGGGATATTTTTCTTATATTTGTGAGTTCAGTTCC
 881 GATGGTGCCCGTGGTCAAAAGCGAAAAACATGGACAATTCCTATTCATTCTTAGCACTTTGACATGTCTTGGGGAAAAGC
 961 TTACATTTTAATTTAAAAGAAAGATCAATTATATCCATGCTTAACAGGATCAGCAGGAGCTTTATAAATGACTTTACAGA
1041 GACTAATAAGGGATTTGATCTTTCTTTTTTTGTTATCGAGGCTTTTGAAATGTGGAACTTGTGTGTTCTGCTTTATATGT
1121 TATATTCAATATCTTTTCAGATGCAGTCTATATTTTATGCTGAGTTTTAAAAATGAAATACTTTATGCAAACAGGCAAAA
1201 TTGGTACCAAAGGGAAACATTAACCATGAGGAAGAGCATTTTTCTAAGGAGAACAGGTGACAATATACACATGTGCGCTA
1281 ATCGTAAAATGAGCATCTTAGTCTTTAAAACACATCAGAATTGAATACGAATAATCTATTTGTCGATGAAATAAACACAA
1361 CTCTTTGAGGATTTGAGACTACATTCACCCTTTATTCACAGTCACTTGCAGTTTTGCTTTTCTCTGCATTTCTCTGCTGT
1441 AAGATGACTGTTGCATTGTTGAATTGTATTTTGAGTGGATATTTTTGTTTGGTAACAATTAAAATTTTAAATCGTAAAAA
1521 ATGAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gugaaUGAAGAAACGUCUACuc 5'
               |: ||||| ||||||  
Target 5' attcaATATCTTTTCAGATGca 3'
1124 - 1145 145.00 -10.70
2
miRNA  3' guGAAUGAAGAAAC-----GUCUACUc 5'
            | | :||||  |     |||:||| 
Target 5' agCATTTTTCTAAGGAGAACAGGTGAc 3'
1235 - 1261 132.00 -10.00
3
miRNA  3' gugaaUGAAGAAAC----GUCUACUc 5'
               |:|||| ||     |||||| 
Target 5' tctgcATTTCTCTGCTGTAAGATGAc 3'
1423 - 1448 127.00 -10.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31584076 4 COSMIC
COSN30109364 8 COSMIC
COSN31600455 12 COSMIC
COSN20075595 15 COSMIC
COSN31589091 26 COSMIC
COSN30512352 54 COSMIC
COSN14848669 64 COSMIC
COSN31513438 80 COSMIC
COSN31542408 103 COSMIC
COSN30576234 109 COSMIC
COSN31575693 118 COSMIC
COSN1328063 194 COSMIC
COSN9499752 422 COSMIC
COSN7786940 439 COSMIC
COSN32199023 539 COSMIC
COSN14902770 565 COSMIC
COSN9499753 604 COSMIC
COSN16473178 710 COSMIC
COSN20706081 1115 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs903177962 2 dbSNP
rs763459835 4 dbSNP
rs1220280685 5 dbSNP
rs377076095 7 dbSNP
rs751885139 8 dbSNP
rs369591001 9 dbSNP
rs1238475328 13 dbSNP
rs1458791360 17 dbSNP
rs779662660 19 dbSNP
rs1379099842 22 dbSNP
rs1456556834 22 dbSNP
rs753448571 24 dbSNP
rs754440236 28 dbSNP
rs372759649 31 dbSNP
rs748046115 34 dbSNP
rs377205127 36 dbSNP
rs772082162 38 dbSNP
rs777741642 40 dbSNP
rs1235204631 41 dbSNP
rs1401365441 45 dbSNP
rs1449216598 47 dbSNP
rs1329428110 50 dbSNP
rs1018120180 60 dbSNP
rs1810126 64 dbSNP
rs1340445505 69 dbSNP
rs973808654 74 dbSNP
rs781692293 78 dbSNP
rs1026765668 79 dbSNP
rs1378481818 80 dbSNP
rs1032630823 82 dbSNP
rs1328885634 91 dbSNP
rs951011183 92 dbSNP
rs191624790 93 dbSNP
rs556353088 97 dbSNP
rs1171316050 101 dbSNP
rs184920672 104 dbSNP
rs542142109 105 dbSNP
rs189849617 106 dbSNP
rs991632584 107 dbSNP
rs527260329 108 dbSNP
rs1382273031 112 dbSNP
rs1182572704 113 dbSNP
rs1490784301 120 dbSNP
rs916077848 135 dbSNP
rs947584128 138 dbSNP
rs1254066349 140 dbSNP
rs1202102872 143 dbSNP
rs1262475982 155 dbSNP
rs547147648 157 dbSNP
rs1284968211 172 dbSNP
rs1429018753 178 dbSNP
rs903295564 197 dbSNP
rs1237533965 198 dbSNP
rs865980633 200 dbSNP
rs1052205551 205 dbSNP
rs1338181945 214 dbSNP
rs541047764 215 dbSNP
rs891003902 228 dbSNP
rs1456422494 229 dbSNP
rs909826911 235 dbSNP
rs570640629 239 dbSNP
rs1008558409 244 dbSNP
rs114301921 246 dbSNP
rs533005883 248 dbSNP
rs995364286 257 dbSNP
rs1159351185 258 dbSNP
rs1472547536 260 dbSNP
rs1026714668 261 dbSNP
rs1055687432 261 dbSNP
rs1366724827 261 dbSNP
rs193175180 262 dbSNP
rs895156042 269 dbSNP
rs1214226308 273 dbSNP
rs1489134478 279 dbSNP
rs982435014 290 dbSNP
rs1360499389 292 dbSNP
rs1208869233 296 dbSNP
rs1383287105 297 dbSNP
rs1035767491 299 dbSNP
rs781767344 305 dbSNP
rs748933081 308 dbSNP
rs1235703147 312 dbSNP
rs959774118 316 dbSNP
rs1013549619 318 dbSNP
rs1046526305 320 dbSNP
rs367559514 320 dbSNP
rs532028299 320 dbSNP
rs550052010 320 dbSNP
rs570006598 320 dbSNP
rs999737030 327 dbSNP
rs1410301325 328 dbSNP
rs1404926710 329 dbSNP
rs112916979 331 dbSNP
rs1243362284 333 dbSNP
rs1032495360 338 dbSNP
rs1167138782 338 dbSNP
rs1461999073 339 dbSNP
rs1315378580 346 dbSNP
rs1191406181 347 dbSNP
rs1478720543 348 dbSNP
rs1242420882 357 dbSNP
rs958201833 363 dbSNP
rs1361146592 369 dbSNP
rs1291442895 379 dbSNP
rs1213816979 384 dbSNP
rs992145509 396 dbSNP
rs1258052725 399 dbSNP
rs916187321 402 dbSNP
rs947533521 407 dbSNP
rs1364540662 408 dbSNP
rs978912662 409 dbSNP
rs1486045993 413 dbSNP
rs1436060731 418 dbSNP
rs1329603924 419 dbSNP
rs770801917 421 dbSNP
rs185463021 424 dbSNP
rs1441807481 430 dbSNP
rs529488108 431 dbSNP
rs1253919409 440 dbSNP
rs1168454506 441 dbSNP
rs1018486681 451 dbSNP
rs773997322 453 dbSNP
rs1171740830 457 dbSNP
rs78995511 458 dbSNP
rs1254551658 459 dbSNP
rs1193870631 462 dbSNP
rs1456931800 470 dbSNP
rs1235763843 476 dbSNP
rs1197322732 480 dbSNP
rs1025385919 485 dbSNP
rs1051893145 492 dbSNP
rs1274286333 494 dbSNP
rs890442694 498 dbSNP
rs1219058601 501 dbSNP
rs112018187 502 dbSNP
rs1305988314 509 dbSNP
rs79466232 515 dbSNP
rs1157030639 518 dbSNP
rs3088441 522 dbSNP
rs995313364 526 dbSNP
rs1048267218 529 dbSNP
rs1400676410 532 dbSNP
rs1333407803 535 dbSNP
rs190765476 539 dbSNP
rs1396587532 554 dbSNP
rs1173889183 558 dbSNP
rs991818638 560 dbSNP
rs115069429 561 dbSNP
rs1035480191 564 dbSNP
rs3088442 565 dbSNP
rs1234027535 574 dbSNP
rs1308030125 575 dbSNP
rs73592949 579 dbSNP
rs750744865 582 dbSNP
rs935391838 584 dbSNP
rs1053846039 586 dbSNP
rs372517273 590 dbSNP
rs968949943 592 dbSNP
rs1240899230 598 dbSNP
rs1353208029 603 dbSNP
rs1307315879 605 dbSNP
rs1254244391 608 dbSNP
rs978858443 608 dbSNP
rs1374133979 614 dbSNP
rs1283530136 615 dbSNP
rs1445652760 618 dbSNP
rs180800333 620 dbSNP
rs1203162512 621 dbSNP
rs1313216513 623 dbSNP
rs1007023751 637 dbSNP
rs1358286579 642 dbSNP
rs1160823614 644 dbSNP
rs1050898 650 dbSNP
rs775802183 652 dbSNP
rs1018975130 662 dbSNP
rs956265570 669 dbSNP
rs1462678064 678 dbSNP
rs997829889 685 dbSNP
rs987944938 686 dbSNP
rs1025252024 689 dbSNP
rs1488157310 691 dbSNP
rs1259246871 692 dbSNP
rs376065278 694 dbSNP
rs2076828 699 dbSNP
rs1317604547 705 dbSNP
rs1278558947 712 dbSNP
rs983854802 717 dbSNP
rs138683758 720 dbSNP
rs1016645130 729 dbSNP
rs1293808463 729 dbSNP
rs1399231246 731 dbSNP
rs943342322 736 dbSNP
rs1338140190 737 dbSNP
rs868312923 743 dbSNP
rs768800428 756 dbSNP
rs1039070069 760 dbSNP
rs141962834 762 dbSNP
rs958796132 765 dbSNP
rs751896705 766 dbSNP
rs185246709 769 dbSNP
rs564065138 777 dbSNP
rs41267801 779 dbSNP
rs1162046546 780 dbSNP
rs1376474760 794 dbSNP
rs931221815 800 dbSNP
rs1420721115 802 dbSNP
rs146317414 804 dbSNP
rs1477738569 807 dbSNP
rs886935657 809 dbSNP
rs1177727599 815 dbSNP
rs1407703753 817 dbSNP
rs1486292041 818 dbSNP
rs1443854599 831 dbSNP
rs1297308398 834 dbSNP
rs1004079140 835 dbSNP
rs1273806296 850 dbSNP
rs949931712 851 dbSNP
rs1305566757 867 dbSNP
rs1297392572 868 dbSNP
rs543702784 881 dbSNP
rs1392957115 882 dbSNP
rs1291412517 884 dbSNP
rs1442550065 886 dbSNP
rs755300793 891 dbSNP
rs72552766 892 dbSNP
rs1053879010 896 dbSNP
rs1371730121 897 dbSNP
rs1252073367 901 dbSNP
rs529425167 903 dbSNP
rs867128722 904 dbSNP
rs181062898 912 dbSNP
rs1022588845 915 dbSNP
rs942900950 919 dbSNP
rs41267803 921 dbSNP
rs1337324240 924 dbSNP
rs901450468 926 dbSNP
rs1311380709 927 dbSNP
rs1300893946 931 dbSNP
rs1196816502 940 dbSNP
rs1235957803 945 dbSNP
rs998406549 946 dbSNP
rs1025829183 949 dbSNP
rs1395024805 955 dbSNP
rs886777678 965 dbSNP
rs1462877208 976 dbSNP
rs1377356569 977 dbSNP
rs1172021314 980 dbSNP
rs1455709159 983 dbSNP
rs1178151229 984 dbSNP
rs1395805577 984 dbSNP
rs1005142475 985 dbSNP
rs1000394329 986 dbSNP
rs1179369746 987 dbSNP
rs867737505 989 dbSNP
rs1265739333 991 dbSNP
rs1482809512 993 dbSNP
rs755687049 993 dbSNP
rs1277855911 997 dbSNP
rs987678056 998 dbSNP
rs111808074 1000 dbSNP
rs191476883 1006 dbSNP
rs1432012752 1017 dbSNP
rs974704381 1031 dbSNP
rs1337011170 1033 dbSNP
rs1309791389 1039 dbSNP
rs1392417906 1058 dbSNP
rs1463665340 1059 dbSNP
rs920591596 1061 dbSNP
rs971193233 1062 dbSNP
rs770513660 1064 dbSNP
rs1354798034 1069 dbSNP
rs115391354 1078 dbSNP
rs537090951 1079 dbSNP
rs1365545506 1099 dbSNP
rs1182458918 1102 dbSNP
rs1291389925 1115 dbSNP
rs1344642555 1117 dbSNP
rs1405267022 1119 dbSNP
rs1255277493 1120 dbSNP
rs375258349 1124 dbSNP
rs143361248 1126 dbSNP
rs1285175308 1132 dbSNP
rs956724183 1133 dbSNP
rs1284950143 1165 dbSNP
rs1338333404 1168 dbSNP
rs1243884665 1169 dbSNP
rs1216919645 1180 dbSNP
rs1048777719 1189 dbSNP
rs908480603 1190 dbSNP
rs939820309 1193 dbSNP
rs1056973467 1196 dbSNP
rs1240431291 1197 dbSNP
rs1355430626 1201 dbSNP
rs1291954031 1202 dbSNP
rs62440430 1210 dbSNP
rs1317918287 1212 dbSNP
rs1399119478 1219 dbSNP
rs942785699 1221 dbSNP
rs1040163468 1226 dbSNP
rs771844755 1228 dbSNP
rs571276725 1232 dbSNP
rs1460964162 1236 dbSNP
rs922813175 1238 dbSNP
rs1271728736 1239 dbSNP
rs1475415189 1243 dbSNP
rs182097457 1255 dbSNP
rs1190604281 1256 dbSNP
rs1047311156 1258 dbSNP
rs747197819 1260 dbSNP
rs752087355 1271 dbSNP
rs1208778478 1273 dbSNP
rs1050908 1277 dbSNP
rs72552767 1278 dbSNP
rs1235613804 1284 dbSNP
rs572152387 1293 dbSNP
rs1335936161 1295 dbSNP
rs1429705080 1301 dbSNP
rs1269930942 1302 dbSNP
rs187135071 1305 dbSNP
rs1032317826 1316 dbSNP
rs892063264 1318 dbSNP
rs1425142051 1329 dbSNP
rs1009448097 1330 dbSNP
rs1392294340 1335 dbSNP
rs1019117448 1345 dbSNP
rs1167028051 1345 dbSNP
rs1358602343 1346 dbSNP
rs557811476 1352 dbSNP
rs1476259462 1353 dbSNP
rs566641877 1354 dbSNP
rs1197720585 1355 dbSNP
rs1027771444 1360 dbSNP
rs1466757013 1361 dbSNP
rs998679077 1362 dbSNP
rs1031631691 1366 dbSNP
rs952008518 1376 dbSNP
rs1272891988 1382 dbSNP
rs1313266740 1385 dbSNP
rs1213236014 1387 dbSNP
rs1358954773 1397 dbSNP
rs983484151 1398 dbSNP
rs908419909 1400 dbSNP
rs1327959435 1401 dbSNP
rs1294426481 1403 dbSNP
rs1353912860 1414 dbSNP
rs527258791 1417 dbSNP
rs993192822 1423 dbSNP
rs917070063 1440 dbSNP
rs1411519135 1447 dbSNP
rs1215709649 1449 dbSNP
rs1243141062 1455 dbSNP
rs759288170 1457 dbSNP
rs915258512 1467 dbSNP
rs948582011 1476 dbSNP
rs1044104344 1483 dbSNP
rs181946142 1488 dbSNP
rs184529888 1492 dbSNP
rs142685529 1498 dbSNP
rs373227049 1502 dbSNP
rs1179601827 1514 dbSNP
rs144564212 1515 dbSNP
rs1444844703 1516 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000392145.1 | 3UTR | AAAAGAUGAAAGAAAUGGUUGCUGAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38226 Liver fibrosis -0.742 5.9e-5 -0.610 1.7e-3 21 Click to see details
GSE32688 Pancreatic cancer 0.317 3.9e-2 0.343 2.7e-2 32 Click to see details
GSE21849 B cell lymphoma 0.302 5.6e-2 0.083 3.3e-1 29 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.256 1.1e-1 -0.269 9.7e-2 25 Click to see details
GSE28544 Breast cancer 0.251 1.2e-1 0.265 1.1e-1 24 Click to see details
GSE19350 CNS germ cell tumors 0.363 1.2e-1 0.531 3.8e-2 12 Click to see details
GSE21687 Ependynoma primary tumors 0.098 2.2e-1 0.118 1.8e-1 64 Click to see details
GSE28260 Renal cortex and medulla -0.186 2.7e-1 -0.291 1.7e-1 13 Click to see details
GSE26953 Aortic valvular endothelial cells 0.129 2.7e-1 0.289 8.5e-2 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.08 3.7e-1 0.002 5.0e-1 20 Click to see details
GSE14794 Lymphoblastoid cells 0.023 4.1e-1 -0.021 4.2e-1 90 Click to see details
GSE17498 Multiple myeloma 0.035 4.2e-1 0.110 2.5e-1 40 Click to see details
GSE27834 Pluripotent stem cells -0.046 4.3e-1 0.197 2.3e-1 16 Click to see details
GSE17306 Multiple myeloma -0.007 4.8e-1 0.473 3.0e-4 49 Click to see details
GSE42095 Differentiated embryonic stem cells 0.001 5.0e-1 0.007 4.9e-1 23 Click to see details
GSE42095 Differentiated embryonic stem cells 0.001 5.0e-1 0.007 4.9e-1 23 Click to see details
GSE42095 Differentiated embryonic stem cells 0.001 5.0e-1 0.007 4.9e-1 23 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.392 0 0.472 0 79 Click to see details
STAD -0.496 0 -0.600 0 29 Click to see details
KIRP -0.416 0.01 -0.501 0 31 Click to see details
PRAD -0.258 0.04 -0.193 0.09 48 Click to see details
ESCA -0.526 0.07 -0.633 0.03 9 Click to see details
KICH -0.306 0.07 -0.291 0.08 24 Click to see details
LUAD -0.289 0.19 -0.182 0.3 11 Click to see details
THCA -0.1 0.23 -0.190 0.07 59 Click to see details
UCEC -0.145 0.28 -0.121 0.31 19 Click to see details
BLCA 0.127 0.31 0.059 0.41 17 Click to see details
LIHC 0.065 0.33 0.008 0.48 49 Click to see details
HNSC -0.054 0.37 0.056 0.36 42 Click to see details
LUSC -0.056 0.37 -0.010 0.48 38 Click to see details
CESC 0.357 0.38 0.500 0.33 3 Click to see details
CHOL -0.073 0.43 -0.083 0.42 9 Click to see details
KIRC -0.019 0.44 -0.012 0.46 65 Click to see details
PAAD -0.001 0.5 0.400 0.3 4 Click to see details
PAAD -0.001 0.5 0.400 0.3 4 Click to see details
PAAD -0.001 0.5 0.400 0.3 4 Click to see details
PAAD -0.001 0.5 0.400 0.3 4 Click to see details
87 hsa-miR-452-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT150000 MIDN midnolin 2 10
MIRT330600 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT358701 SUB1 SUB1 homolog, transcriptional regulator 2 4
MIRT362854 EIF4H eukaryotic translation initiation factor 4H 2 2
MIRT447215 ATXN7 ataxin 7 2 2
MIRT466655 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT483979 PANK1 pantothenate kinase 1 2 8
MIRT485118 SF3B3 splicing factor 3b subunit 3 2 2
MIRT488864 AUTS8 Autism, susceptibility to, 8 2 2
MIRT492293 SH2B3 SH2B adaptor protein 3 2 2
MIRT492976 NCK2 NCK adaptor protein 2 2 2
MIRT497410 LRRC40 leucine rich repeat containing 40 2 2
MIRT511143 MRPL17 mitochondrial ribosomal protein L17 2 6
MIRT512650 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT513017 NSFL1C NSFL1 cofactor 2 6
MIRT520445 TSPAN2 tetraspanin 2 2 6
MIRT527995 NDNF neuron derived neurotrophic factor 2 2
MIRT528667 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT533512 TRIM71 tripartite motif containing 71 2 2
MIRT537404 FBXO47 F-box protein 47 2 2
MIRT538161 DCP2 decapping mRNA 2 2 2
MIRT539124 ARHGEF17 Rho guanine nucleotide exchange factor 17 2 2
MIRT540666 MIS18A MIS18 kinetochore protein A 2 4
MIRT542948 GDF11 growth differentiation factor 11 2 2
MIRT547534 MAML3 mastermind like transcriptional coactivator 3 2 2
MIRT559033 C20orf24 chromosome 20 open reading frame 24 2 4
MIRT559554 ARF6 ADP ribosylation factor 6 2 2
MIRT570177 RCBTB1 RCC1 and BTB domain containing protein 1 2 2
MIRT573149 ITGA9 integrin subunit alpha 9 2 2
MIRT575849 Rab1 RAB1A, member RAS oncogene family 1 1
MIRT611034 RRP1B ribosomal RNA processing 1B 2 2
MIRT616281 HMGB1 high mobility group box 1 2 2
MIRT618372 PRKG2 protein kinase, cGMP-dependent, type II 2 2
MIRT619540 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT622303 SGIP1 SH3 domain GRB2 like endophilin interacting protein 1 2 2
MIRT622590 PRRG4 proline rich and Gla domain 4 2 2
MIRT624441 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT637089 KLRD1 killer cell lectin like receptor D1 2 2
MIRT639084 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT639334 NINJ1 ninjurin 1 2 2
MIRT639798 EIF3E eukaryotic translation initiation factor 3 subunit E 2 2
MIRT640851 RAB3B RAB3B, member RAS oncogene family 2 2
MIRT641628 KIAA1244 ARFGEF family member 3 1 1
MIRT642634 EPPIN epididymal peptidase inhibitor 2 2
MIRT643053 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643416 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT645586 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT647393 FAM181B family with sequence similarity 181 member B 2 2
MIRT649411 CDC14B cell division cycle 14B 2 2
MIRT649477 CLDN16 claudin 16 2 2
MIRT651307 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT651387 ZBTB16 zinc finger and BTB domain containing 16 2 2
MIRT653411 SLC7A2 solute carrier family 7 member 2 2 2
MIRT654084 RSPH4A radial spoke head 4 homolog A 2 2
MIRT654613 PTPRM protein tyrosine phosphatase, receptor type M 2 2
MIRT655338 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT656173 MRPL44 mitochondrial ribosomal protein L44 2 2
MIRT657272 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 2
MIRT657881 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT659875 CAPRIN1 cell cycle associated protein 1 2 2
MIRT662381 ICA1L islet cell autoantigen 1 like 2 4
MIRT666308 SLC22A3 solute carrier family 22 member 3 2 2
MIRT667274 NAV1 neuron navigator 1 2 2
MIRT667614 LIMCH1 LIM and calponin homology domains 1 2 2
MIRT674242 NUP62 nucleoporin 62 2 4
MIRT690386 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT693402 NUDT16 nudix hydrolase 16 2 2
MIRT702503 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT708632 STMN4 stathmin 4 2 2
MIRT708839 SCAND3 zinc finger BED-type containing 9 1 1
MIRT709016 HSBP1 heat shock factor binding protein 1 2 2
MIRT709235 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT710885 PARL presenilin associated rhomboid like 2 2
MIRT712262 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712573 ATP2B4 ATPase plasma membrane Ca2+ transporting 4 2 2
MIRT715046 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT718905 GALR1 galanin receptor 1 2 2
MIRT719368 FEM1A fem-1 homolog A 2 2
MIRT719495 SEC24B SEC24 homolog B, COPII coat complex component 2 2
MIRT719601 PRKX protein kinase, X-linked 2 2
MIRT719891 RRP36 ribosomal RNA processing 36 2 2
MIRT720063 ZNF449 zinc finger protein 449 2 2
MIRT721679 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT721724 VTI1A vesicle transport through interaction with t-SNAREs 1A 2 2
MIRT723370 ZNF470 zinc finger protein 470 2 2
MIRT724941 TXNL1 thioredoxin like 1 2 2
MIRT725302 NLRC5 NLR family CARD domain containing 5 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-452 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-452 Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice liver 20145010 2010 up-regulated
miR-452 Tert-butyl hydroperoxide (t-BHP) NULL 6410 Microarray mouse auditory cells 20510889 2010 down-regulated
miR-452 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CP20)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-mir-452 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-452-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-452-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-452-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (HCT8)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-452-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-452-3p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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