miRTarBase - #MIRT666339


—
pre-miRNA Information
pre-miRNA hsa-mir-4708   
Genomic Coordinates chr14: 65335117 - 65335183
Description Homo sapiens miR-4708 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4708-5p
Sequence 9| AGAGAUGCCGCCUUGCUCCUU |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1017378847 9 dbSNP
rs750825813 10 dbSNP
rs1297395738 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SKAP2   
Synonyms PRAP, RA70, SAPS, SCAP2, SKAP-HOM, SKAP55R
Description src kinase associated phosphoprotein 2
Transcript NM_003930   
Expression
Putative miRNA Targets on SKAP2
3'UTR of SKAP2
(miRNA target sites are highlighted)		 
>SKAP2|NM_003930|3'UTR
   1 GAGTCCTGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATTTAGAAGCGTCATGAAAGCACGAGTGACAGC
  81 TCCTAACCTCTCCTTGTTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTCGCTCATTAAAATATTCCTCT
 161 GATGTGAAATTAAATGAAGGATATTAATGTAAATTAGATGCAACCAGTTAAGTTATACCTGTTGCTATTTTGCAAAGAAA
 241 TAATTATAGTTTTTATTTACCCATTTGATTTGTGTGAAGAATTCATCACTATTTTATACGTAACATATAGTCTACTATAG
 321 CATAGTATGCTACTATTGCTACTTCTGGTGTGATTTGTAATGTTTCTTAATCATTGGACATCAATTATTTTTAGAGAGTA
 401 ATGTATAATTTCATAGCATTTTAAATTTAGTGTATCATGCGAGTTTTTTTTGGTAGATGCTGAAGAATGTGGTTGCTAAA
 481 CAAAGAATGCTAAAGAATGTTCAAACTTTATAGATAACTTTATTGTTATTATTTATTTTCACACATTTAATTCCTATTAA
 561 GTACAGCCGCAAGAAAGAAAAAATGATGAAGTTGCAAATGGCAGTGTGCTGTCACCTGCAACAGAAGTGCGTACCAGAAG
 641 TATGACTCATGCAAAGCATTTTACCGTACAAATATCCTGGTGCGATGATGGGCCTGGCAACATTTTCTACTGTACTTTTG
 721 TTTAAATTTAATGAAACAAAAAATTCCTAAGAAATACCACCCTACCACTAACAAAATGGTATAAAGAATCTCCCAGCCAG
 801 GCCAACATGGTGAAACCCTGTCTCTACTAAAAATTAGCCAAGTGTGGTAATGTTCACCTGCAGTCCCAGCTACTTGGGAG
 881 GCCAAGGCACGAGAATTGCTTGAACAAGGTAGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGG
 961 CGACAGAGTGAGACTCCATCTCAGAAAAAAAAAAAAAAAAAAACAGAATCTCAGTGTATTCTCAAAGTAAAAAGGCATAA
1041 CCAAGCACTCTCTTATCTTGCCTTATTGCTATACTATTTACATCCCACTGCAGAACAGCAGATTTGAGGCTTTTCTATAT
1121 ACTTCTCAGAGCACTGAAAAGAAAGGAAGGGTTTGCAGAGGAGAGTGTAGAAATCCCAGTGGTAGCATGTACCAACAGGT
1201 GAGTAGAAAGGTAGTGTTAGCCTGACATTTGAGTTATACTCTGTGCTGCCTGAGCAAGATTTGTAGAATCATATAATTAC
1281 CTTTTCATGTATATTTGAAATCAGAGGTGTTTAAAATACCTATGAGATACCAATGTAGCCTTAACATATGTCAAAATGCA
1361 TTGCTGGTTAGATAATTATTTGGACTACACATAAACTCCTAATATTGAATCATTACCTATCAGGTATTATCTTTATGGAA
1441 CTTTTCAATATCTTTGCTTTATAAAGATTCTAAACATGTATCTGAGCTGGTAATATTTTAAAATCTCCATTATTTGTGTA
1521 AAACTGTTTATAAGCAGTGTTTGAGAGGGTCTGCTTTACCATTACCCCCTCAATATCATGATCATCCAATCTCAAATGTG
1601 AAAAAAAAAAAGAAATTTGATTTTAGGGATTGTGAGTAAACAAGTTTATATAGAGAGACATTGTGAAGTTAAAGTTTTCA
1681 GAAGTTACATTTGTGCAGTTCTTACCTTTTCCTCATATAGTGCCATTGAAATAGACTGAAATTATCTTGGCAAAAGTTAG
1761 ACAACCAAAGACGACTTTAGTGGACTGGTTTTCAAAACTTGAGCAGCTGAAAAGCAAAAGCCGTTGTTTCCCATGACAAT
1841 GTAGCCTTTGTGGATTTGGGTTTGTGCTTTGGGTTGAAAAGAAGTTTTTAGTCCTAGGCCAGTAGATGGCAGCAGCTTTT
1921 CATTGCAGACAAAACCTCTTGAAACCCTTCCCCCATGGCACAAACTCGCCCATGATGGAAAGCATCTAGATTTCTGCCTC
2001 CTTTTACAGTTAATCCAGGAGAGGGAGTCCTTTGCCAACTGATGACCAACAGTTCCAAGCCAGATAGTCTCGTGAACAGT
2081 GACAATACAGAAATAAGGTGTTATTTCTGTTCAGATCTCCACCGGCCTTTGTTCTTTTAAAACTTGAATATAGGTGGGAG
2161 ACATAAGAAAGGAAAGAAAAGACTTAAAACTGGAGTGACAGGACAAATAATCATTACTTTCAATTCATGACTGCTTTATA
2241 TTCATTTGATGAAATCATTTGTATACAAACCAGGGAGAGTTTTCTTTACACCCTTGACAATATATCACATACTCTTCAAG
2321 ATCATAATAATATCATTAATATAAATTTAAACAACATGGCTTGTTAGAAAATATGCTAATTGCTATGGTCTCATTATGTT
2401 TGCTTAGCTTTTATTTGTTTTTCTGTGAACAGTTAGAGAGCTAATTTTTTTCAAAGGTGATTGTAAGTCATATTTTATAT
2481 AGCATTTTGCTTGATTATTTGCTCTGTACTGAATTTGTACTCTATTGCCATTAGATCTTACAATAATGTTCCACTCTGCA
2561 AATTTTTAAGGTTCAAATAAAGTTTAATTGTTTGCAAACTGTTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uucCUCGUUCCGCCGUAGAGa 5'
             |||::|| |  |||||| 
Target 5' acaGAGTGAGACTCCATCTCa 3'
 963 - 983 134.00 -12.00
2 
miRNA  3' uuccucGUUCCGC----CGUAGAga 5'
                || | :|    ||||||  
Target 5' ctcgccCATGATGGAAAGCATCTag 3'
 1965 - 1989 121.00 -7.70
3 
miRNA  3' uuCCUCGUUCCGCCGU-AGAGa 5'
            ||  :||    ||| |||| 
Target 5' aaGGCATAACCAAGCACTCTCt 3'
 1032 - 1053 111.00 -8.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN32059356 1 COSMIC
COSN28648315 53 COSMIC
COSN21619885 402 COSMIC
COSN16875453 491 COSMIC
COSN29834427 701 COSMIC
COSN7976185 1168 COSMIC
COSN9983939 1346 COSMIC
COSN9983938 1426 COSMIC
COSN22862222 1705 COSMIC
COSN2217594 1891 COSMIC
COSN20103982 2035 COSMIC
COSN9983937 2270 COSMIC
COSN2217593 2321 COSMIC
COSN9940392 2441 COSMIC
COSN9983936 2462 COSMIC
COSN31585459 2528 COSMIC
COSN31589528 2651 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1447370281 5 dbSNP
rs904660856 17 dbSNP
rs770568326 18 dbSNP
rs1421321623 20 dbSNP
rs1358339938 21 dbSNP
rs529899363 27 dbSNP
rs1405523161 42 dbSNP
rs777093193 45 dbSNP
rs3735549 53 dbSNP
rs1244593243 58 dbSNP
rs1291757438 62 dbSNP
rs774886198 63 dbSNP
rs1051849912 66 dbSNP
rs932971844 67 dbSNP
rs1220781285 68 dbSNP
rs139464146 75 dbSNP
rs1365206001 76 dbSNP
rs919192101 92 dbSNP
rs1197005517 114 dbSNP
rs527667697 129 dbSNP
rs565247317 130 dbSNP
rs1185543292 132 dbSNP
rs909038026 133 dbSNP
rs763095706 149 dbSNP
rs1476325946 151 dbSNP
rs1165864851 152 dbSNP
rs1372695638 167 dbSNP
rs1317982994 173 dbSNP
rs1460563266 186 dbSNP
rs1299955359 187 dbSNP
rs1456210838 190 dbSNP
rs1395891433 191 dbSNP
rs1359420415 206 dbSNP
rs1311477724 211 dbSNP
rs984259917 223 dbSNP
rs1018746255 232 dbSNP
rs970527302 234 dbSNP
rs1305402056 247 dbSNP
rs1435340446 254 dbSNP
rs773327377 257 dbSNP
rs993252048 270 dbSNP
rs112439134 271 dbSNP
rs1208588159 274 dbSNP
rs1259381594 286 dbSNP
rs1485903435 291 dbSNP
rs1031887638 292 dbSNP
rs1261378348 300 dbSNP
rs531814916 322 dbSNP
rs999031532 335 dbSNP
rs1250396811 355 dbSNP
rs1206942711 360 dbSNP
rs968894411 362 dbSNP
rs13247713 367 dbSNP
rs1029783686 373 dbSNP
rs1415858349 379 dbSNP
rs902733064 391 dbSNP
rs999739224 391 dbSNP
rs1021746840 396 dbSNP
rs1007334711 406 dbSNP
rs1295709520 426 dbSNP
rs1043416345 429 dbSNP
rs1231409066 435 dbSNP
rs888875112 437 dbSNP
rs1051498400 438 dbSNP
rs1010960726 441 dbSNP
rs1310591165 445 dbSNP
rs997592099 449 dbSNP
rs897458581 467 dbSNP
rs1485034705 469 dbSNP
rs141436037 480 dbSNP
rs1262672711 481 dbSNP
rs1279353515 491 dbSNP
rs1191827656 492 dbSNP
rs769833607 501 dbSNP
rs1228806434 504 dbSNP
rs1158835085 505 dbSNP
rs941923733 522 dbSNP
rs374029297 523 dbSNP
rs535171189 535 dbSNP
rs1369745208 545 dbSNP
rs947885700 550 dbSNP
rs1379249697 551 dbSNP
rs543232775 555 dbSNP
rs1464235611 556 dbSNP
rs1358157816 560 dbSNP
rs916000161 560 dbSNP
rs992887747 563 dbSNP
rs1216206456 575 dbSNP
rs148372191 575 dbSNP
rs1430761398 576 dbSNP
rs924609229 578 dbSNP
rs929212458 579 dbSNP
rs1211921171 580 dbSNP
rs144404492 592 dbSNP
rs187834240 593 dbSNP
rs779832659 598 dbSNP
rs1428060786 622 dbSNP
rs1256954804 634 dbSNP
rs551219547 646 dbSNP
rs1021824509 649 dbSNP
rs1421289795 658 dbSNP
rs758014778 661 dbSNP
rs1393349312 671 dbSNP
rs1459494036 683 dbSNP
rs1257025534 684 dbSNP
rs1205656308 689 dbSNP
rs1394516387 689 dbSNP
rs1440808063 697 dbSNP
rs1344009166 710 dbSNP
rs953531552 714 dbSNP
rs531137922 723 dbSNP
rs375485011 733 dbSNP
rs1226601705 734 dbSNP
rs997256947 742 dbSNP
rs1334443471 746 dbSNP
rs1231639843 747 dbSNP
rs1275147717 751 dbSNP
rs985989261 756 dbSNP
rs1203868462 762 dbSNP
rs1231741335 766 dbSNP
rs780091175 775 dbSNP
rs1481898684 782 dbSNP
rs955449881 786 dbSNP
rs558393743 787 dbSNP
rs1029786838 789 dbSNP
rs1014579682 794 dbSNP
rs1006170196 796 dbSNP
rs1408933597 799 dbSNP
rs1393746200 800 dbSNP
rs1326267205 806 dbSNP
rs1356224301 807 dbSNP
rs1354464393 809 dbSNP
rs1308233906 814 dbSNP
rs778453279 818 dbSNP
rs1312080401 822 dbSNP
rs1372791421 832 dbSNP
rs887708614 850 dbSNP
rs1022996480 865 dbSNP
rs1044966032 874 dbSNP
rs1270897539 875 dbSNP
rs1309787421 879 dbSNP
rs947883372 884 dbSNP
rs1011137578 886 dbSNP
rs894841660 886 dbSNP
rs1484919712 901 dbSNP
rs1190510213 902 dbSNP
rs896286316 908 dbSNP
rs756762070 915 dbSNP
rs372090166 917 dbSNP
rs1172983856 919 dbSNP
rs1410482879 919 dbSNP
rs1167042184 928 dbSNP
rs753418278 931 dbSNP
rs1003302970 938 dbSNP
rs1422100448 942 dbSNP
rs1430197226 944 dbSNP
rs1268515098 946 dbSNP
rs1364233996 951 dbSNP
rs1229193702 959 dbSNP
rs938768258 959 dbSNP
rs1183144639 962 dbSNP
rs1483953044 965 dbSNP
rs1213488530 972 dbSNP
rs1446102146 973 dbSNP
rs764800647 973 dbSNP
rs1190509094 974 dbSNP
rs1249357164 978 dbSNP
rs924640306 979 dbSNP
rs1475477157 981 dbSNP
rs569526705 995 dbSNP
rs1047615675 1002 dbSNP
rs143960607 1003 dbSNP
rs1383919308 1015 dbSNP
rs1398717448 1016 dbSNP
rs914810559 1018 dbSNP
rs1038046866 1019 dbSNP
rs943299127 1045 dbSNP
rs1302692883 1047 dbSNP
rs183543583 1047 dbSNP
rs1237097376 1049 dbSNP
rs1394637298 1051 dbSNP
rs567254887 1054 dbSNP
rs1350464105 1062 dbSNP
rs1203720718 1064 dbSNP
rs1242036670 1065 dbSNP
rs1333502271 1076 dbSNP
rs1465056419 1083 dbSNP
rs1212535613 1084 dbSNP
rs953705151 1090 dbSNP
rs985386716 1092 dbSNP
rs532946023 1097 dbSNP
rs975853226 1099 dbSNP
rs961776929 1100 dbSNP
rs868691939 1104 dbSNP
rs1348175485 1107 dbSNP
rs1325347106 1110 dbSNP
rs1327291807 1114 dbSNP
rs190629830 1118 dbSNP
rs1392130245 1121 dbSNP
rs1324823793 1122 dbSNP
rs571569859 1132 dbSNP
rs190033 1141 dbSNP
rs1335679771 1146 dbSNP
rs1005909744 1153 dbSNP
rs1281577274 1154 dbSNP
rs1329433339 1158 dbSNP
rs1232258824 1159 dbSNP
rs887412389 1180 dbSNP
rs169873 1193 dbSNP
rs959614994 1196 dbSNP
rs1023981522 1205 dbSNP
rs1459993520 1217 dbSNP
rs1417248502 1233 dbSNP
rs1012158169 1235 dbSNP
rs896351311 1237 dbSNP
rs1003188328 1242 dbSNP
rs906296322 1248 dbSNP
rs1056284216 1249 dbSNP
rs1183733441 1254 dbSNP
rs551591982 1258 dbSNP
rs1026100411 1261 dbSNP
rs993228060 1262 dbSNP
rs1164548107 1271 dbSNP
rs1415919790 1273 dbSNP
rs1269440809 1274 dbSNP
rs1207977387 1278 dbSNP
rs938799222 1280 dbSNP
rs531880147 1286 dbSNP
rs1331330504 1295 dbSNP
rs1351433776 1299 dbSNP
rs562969460 1308 dbSNP
rs543273461 1315 dbSNP
rs943289920 1316 dbSNP
rs529495567 1318 dbSNP
rs560782710 1320 dbSNP
rs1041742726 1321 dbSNP
rs751912712 1324 dbSNP
rs947397001 1325 dbSNP
rs77746300 1333 dbSNP
rs1326670645 1343 dbSNP
rs766710196 1364 dbSNP
rs932233797 1371 dbSNP
rs923462396 1372 dbSNP
rs976260852 1373 dbSNP
rs1185530640 1374 dbSNP
rs962181944 1377 dbSNP
rs907629409 1378 dbSNP
rs1188342128 1380 dbSNP
rs571952368 1382 dbSNP
rs369836169 1383 dbSNP
rs984505286 1388 dbSNP
rs1439349602 1395 dbSNP
rs1372538004 1396 dbSNP
rs1460938717 1397 dbSNP
rs1171093524 1399 dbSNP
rs1339009270 1403 dbSNP
rs558488969 1404 dbSNP
rs1371709472 1409 dbSNP
rs1394318176 1413 dbSNP
rs1434550617 1414 dbSNP
rs1321326755 1416 dbSNP
rs938025967 1418 dbSNP
rs1356977871 1419 dbSNP
rs1396207807 1419 dbSNP
rs59588152 1419 dbSNP
rs1294256272 1420 dbSNP
rs951836447 1420 dbSNP
rs1023299645 1421 dbSNP
rs1158192337 1421 dbSNP
rs1012604137 1430 dbSNP
rs1228941236 1430 dbSNP
rs1208485811 1431 dbSNP
rs960644942 1431 dbSNP
rs1034873850 1432 dbSNP
rs1261270398 1432 dbSNP
rs200768023 1433 dbSNP
rs922583966 1433 dbSNP
rs1191449639 1434 dbSNP
rs945471471 1434 dbSNP
rs915401422 1435 dbSNP
rs1248521154 1436 dbSNP
rs989626236 1436 dbSNP
rs1182274338 1438 dbSNP
rs1297624085 1438 dbSNP
rs1382325263 1438 dbSNP
rs1436723247 1438 dbSNP
rs369317261 1438 dbSNP
rs376030200 1438 dbSNP
rs542284535 1438 dbSNP
rs959910727 1439 dbSNP
rs1248678740 1442 dbSNP
rs1468443703 1449 dbSNP
rs926835715 1462 dbSNP
rs902319918 1463 dbSNP
rs1463142421 1465 dbSNP
rs146947306 1466 dbSNP
rs750654215 1473 dbSNP
rs1361722185 1476 dbSNP
rs1458430313 1482 dbSNP
rs970405688 1483 dbSNP
rs1393036763 1489 dbSNP
rs575757675 1505 dbSNP
rs1346605109 1521 dbSNP
rs893150082 1525 dbSNP
rs555821957 1526 dbSNP
rs931945817 1528 dbSNP
rs1223011415 1530 dbSNP
rs1304513851 1531 dbSNP
rs1232488341 1540 dbSNP
rs879675192 1541 dbSNP
rs923564333 1543 dbSNP
rs761833104 1547 dbSNP
rs1211890903 1550 dbSNP
rs1040610577 1551 dbSNP
rs940848463 1561 dbSNP
rs1370951737 1569 dbSNP
rs908033406 1574 dbSNP
rs1489062055 1577 dbSNP
rs984578801 1595 dbSNP
rs776726387 1597 dbSNP
rs1324750532 1598 dbSNP
rs113081607 1603 dbSNP
rs916263207 1605 dbSNP
rs888933981 1612 dbSNP
rs990515692 1613 dbSNP
rs1404553302 1617 dbSNP
rs10248592 1622 dbSNP
rs1433830569 1631 dbSNP
rs188383860 1636 dbSNP
rs1441341623 1646 dbSNP
rs1296260932 1648 dbSNP
rs1170400287 1655 dbSNP
rs1034906557 1661 dbSNP
rs1241018956 1671 dbSNP
rs997383733 1672 dbSNP
rs1187569527 1673 dbSNP
rs138557030 1674 dbSNP
rs901213632 1676 dbSNP
rs1322889859 1686 dbSNP
rs1204383374 1697 dbSNP
rs966553167 1699 dbSNP
rs1443810749 1708 dbSNP
rs1254911203 1725 dbSNP
rs1484264584 1726 dbSNP
rs1183347258 1732 dbSNP
rs1209230047 1733 dbSNP
rs1256384361 1742 dbSNP
rs1347587605 1751 dbSNP
rs1183125991 1754 dbSNP
rs1413820942 1756 dbSNP
rs1022064091 1760 dbSNP
rs1012103321 1762 dbSNP
rs893234169 1767 dbSNP
rs545443438 1768 dbSNP
rs915307565 1769 dbSNP
rs1269692514 1783 dbSNP
rs996195925 1797 dbSNP
rs150085557 1799 dbSNP
rs1286054839 1808 dbSNP
rs926762220 1816 dbSNP
rs559597098 1824 dbSNP
rs982400168 1829 dbSNP
rs1344919354 1865 dbSNP
rs1040682677 1875 dbSNP
rs1311263364 1876 dbSNP
rs970961811 1882 dbSNP
rs1280011193 1883 dbSNP
rs918935395 1887 dbSNP
rs374752394 1890 dbSNP
rs1211859568 1891 dbSNP
rs1370933455 1912 dbSNP
rs971719317 1915 dbSNP
rs1309549815 1918 dbSNP
rs1184241488 1928 dbSNP
rs756918452 1930 dbSNP
rs963470196 1933 dbSNP
rs1172817077 1934 dbSNP
rs1408154793 1935 dbSNP
rs746703526 1941 dbSNP
rs1415941558 1958 dbSNP
rs1336447250 1963 dbSNP
rs1418645429 1973 dbSNP
rs1016044011 1983 dbSNP
rs1295411023 1987 dbSNP
rs760621242 1991 dbSNP
rs866279756 1994 dbSNP
rs1303283287 2000 dbSNP
rs775345382 2001 dbSNP
rs930779366 2003 dbSNP
rs916353066 2008 dbSNP
rs990939181 2020 dbSNP
rs1206289921 2021 dbSNP
rs1473476452 2027 dbSNP
rs1415280257 2031 dbSNP
rs1186769975 2033 dbSNP
rs1485589259 2034 dbSNP
rs1252998271 2035 dbSNP
rs953252021 2041 dbSNP
rs551799011 2043 dbSNP
rs796682530 2045 dbSNP
rs1426153351 2046 dbSNP
rs1478926592 2046 dbSNP
rs560723256 2046 dbSNP
rs1400299093 2048 dbSNP
rs997395048 2050 dbSNP
rs1272878725 2060 dbSNP
rs13186 2062 dbSNP
rs978000144 2066 dbSNP
rs1329841554 2067 dbSNP
rs1042389788 2072 dbSNP
rs1009543403 2074 dbSNP
rs1436479822 2082 dbSNP
rs893788090 2084 dbSNP
rs1226141021 2085 dbSNP
rs1269608253 2087 dbSNP
rs1053898639 2096 dbSNP
rs1358545154 2107 dbSNP
rs1291737448 2113 dbSNP
rs1265253039 2115 dbSNP
rs1453198476 2119 dbSNP
rs938094031 2123 dbSNP
rs966586024 2127 dbSNP
rs1232904419 2128 dbSNP
rs183102987 2130 dbSNP
rs989345478 2132 dbSNP
rs1309647040 2139 dbSNP
rs1157266596 2140 dbSNP
rs919478798 2152 dbSNP
rs1457886752 2167 dbSNP
rs1164225332 2173 dbSNP
rs972710501 2175 dbSNP
rs1388995384 2205 dbSNP
rs191244740 2206 dbSNP
rs1335597656 2207 dbSNP
rs941727260 2213 dbSNP
rs1029087716 2218 dbSNP
rs1324103793 2221 dbSNP
rs1350719237 2256 dbSNP
rs1232166207 2257 dbSNP
rs1406661953 2262 dbSNP
rs996657525 2264 dbSNP
rs1263097078 2267 dbSNP
rs1210409947 2268 dbSNP
rs1358407513 2268 dbSNP
rs755381122 2273 dbSNP
rs1481988434 2274 dbSNP
rs908865220 2278 dbSNP
rs371976338 2279 dbSNP
rs1186966326 2285 dbSNP
rs1366746033 2296 dbSNP
rs527515488 2305 dbSNP
rs549465854 2307 dbSNP
rs10233843 2317 dbSNP
rs560692218 2319 dbSNP
rs1428286444 2324 dbSNP
rs1472723676 2344 dbSNP
rs1310179661 2361 dbSNP
rs1413658619 2363 dbSNP
rs1413734945 2365 dbSNP
rs967282048 2370 dbSNP
rs1341787495 2379 dbSNP
rs1018938940 2386 dbSNP
rs546990132 2387 dbSNP
rs35642976 2389 dbSNP
rs1179359384 2391 dbSNP
rs1339900514 2394 dbSNP
rs1005169324 2398 dbSNP
rs1275033522 2401 dbSNP
rs1483519569 2402 dbSNP
rs754218819 2405 dbSNP
rs1232865583 2406 dbSNP
rs1254306283 2407 dbSNP
rs1425707998 2417 dbSNP
rs10274472 2420 dbSNP
rs10244663 2427 dbSNP
rs1271362103 2432 dbSNP
rs1170912363 2449 dbSNP
rs930832123 2459 dbSNP
rs895295157 2462 dbSNP
rs750505437 2471 dbSNP
rs369413829 2472 dbSNP
rs1396116915 2476 dbSNP
rs185970970 2480 dbSNP
rs939083332 2481 dbSNP
rs1316930776 2483 dbSNP
rs1362980126 2487 dbSNP
rs140742047 2492 dbSNP
rs977740391 2503 dbSNP
rs945020556 2505 dbSNP
rs180750672 2506 dbSNP
rs1254546993 2507 dbSNP
rs949558357 2508 dbSNP
rs897976112 2510 dbSNP
rs1036653889 2512 dbSNP
rs118103246 2518 dbSNP
rs1275437791 2521 dbSNP
rs774487079 2528 dbSNP
rs1191095677 2531 dbSNP
rs953938239 2532 dbSNP
rs573509239 2537 dbSNP
rs757349650 2541 dbSNP
rs553973316 2548 dbSNP
rs1457279618 2554 dbSNP
rs533743198 2557 dbSNP
rs1157796777 2558 dbSNP
rs1390439239 2559 dbSNP
rs10244449 2583 dbSNP
rs189840554 2588 dbSNP
rs1321220318 2594 dbSNP
rs1281935489 2595 dbSNP
rs1019012599 2597 dbSNP
rs1192078622 2601 dbSNP
rs1384875616 2612 dbSNP
rs1455984362 2621 dbSNP
rs1314197954 2627 dbSNP
rs186213072 2635 dbSNP
rs950659123 2636 dbSNP
rs1210657345 2637 dbSNP
rs151004359 2650 dbSNP
rs549504830 2657 dbSNP
rs895338401 2669 dbSNP
rs1262776020 2675 dbSNP
rs1032348452 2685 dbSNP
rs1002183390 2689 dbSNP
rs905180696 2695 dbSNP
rs535913769 2698 dbSNP
rs1279088723 2700 dbSNP
rs1055686429 2701 dbSNP
rs1409309783 2704 dbSNP
rs1003637667 2707 dbSNP
rs530571223 2708 dbSNP
rs1458415906 2709 dbSNP
rs1159184851 2711 dbSNP
rs1025086406 2714 dbSNP
rs984895447 2725 dbSNP
rs1456294647 2731 dbSNP
rs906309006 2738 dbSNP
rs1302555962 2743 dbSNP
rs1042081770 2747 dbSNP
rs1368086863 2748 dbSNP
rs374948008 2755 dbSNP
rs1288025310 2760 dbSNP
rs1348794118 2772 dbSNP
rs1230303902 2786 dbSNP
rs1268803918 2787 dbSNP
rs1321665297 2790 dbSNP
rs1220064250 2797 dbSNP
rs1267726953 2802 dbSNP
rs1489051293 2807 dbSNP
rs945051693 2831 dbSNP
rs1435254252 2832 dbSNP
rs576826741 2833 dbSNP
rs1473330751 2837 dbSNP
rs1245070613 2854 dbSNP
rs1412384651 2862 dbSNP
rs1421521256 2864 dbSNP
rs1166908820 2871 dbSNP
rs762796825 2875 dbSNP
rs914883916 2878 dbSNP
rs1053748731 2885 dbSNP
rs898026068 2891 dbSNP
rs1428884057 2903 dbSNP
rs1305881239 2911 dbSNP
rs182025800 2914 dbSNP
rs750821744 2915 dbSNP
rs17154295 2917 dbSNP
rs1177289368 2931 dbSNP
rs976596123 2937 dbSNP
rs762031146 2946 dbSNP
rs1050107732 2947 dbSNP
rs965186358 2949 dbSNP
rs547221032 2957 dbSNP
rs983503545 2958 dbSNP
rs1483845886 2962 dbSNP
rs1205492893 2963 dbSNP
rs142714228 2977 dbSNP
rs1471556595 2979 dbSNP
rs1183040772 2980 dbSNP
rs564816201 2990 dbSNP
rs1040139331 2993 dbSNP
rs1166503584 2997 dbSNP
rs1391831339 3002 dbSNP
rs1430129753 3011 dbSNP
rs1329876142 3018 dbSNP
rs1173549062 3020 dbSNP
rs1450247016 3024 dbSNP
rs1445935471 3025 dbSNP
rs1304596822 3033 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uucCUCGUUCCGCCGUAGAGa 5'
             |||::|| |  |||||| 
Target 5' -caGAGUGAGACUCCAUCUCa 3'
 		1 - 20
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903829
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / CTLTD_shCTL_a
Location of target site NM_003930 | 3UTR | CGCCACUGCACUCCAGCCUGGGCGACAGAGUGAGACUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903831
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / 124TD_shELAVL3_a
Location of target site NM_003930 | 3UTR | CGCCACUGCACUCCAGCCUGGGCGACAGAGUGAGACUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_003930 | 3UTR | CUUGGGAGGCCAAGGCACGAGAAUUGCUUGAACAAGGUAGGCAGAGGUUGCAGUGAGCCAAGAUCGCGCCACUGCACUCCAGCCUGGGCGACAGAGUGAGACUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_003930 | 3UTR | AAGGCACGAGAAUUGCUUGAACAAGGUAGGCAGAGGUUGCAGUGAGCCAAGAUCGCGCCACUGCACUCCAGCCUGGGCGACAGAGUGAGACUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000345317.2 | 3UTR | CAGAGUGAGACUCCAUCUCAGAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
94 hsa-miR-4708-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT095681 RBM27 RNA binding motif protein 27 2 4
MIRT104033 USP42 ubiquitin specific peptidase 42 2 6
MIRT114773 CMPK1 cytidine/uridine monophosphate kinase 1 2 2
MIRT246923 CCND1 cyclin D1 2 2
MIRT392569 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT443949 LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 2 2
MIRT446695 PAPPA pappalysin 1 2 2
MIRT447383 VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2 2
MIRT449321 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT449717 C1orf61 chromosome 1 open reading frame 61 2 2
MIRT449738 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2 2
MIRT450531 PGLS 6-phosphogluconolactonase 2 2
MIRT455650 YARS tyrosyl-tRNA synthetase 2 2
MIRT458036 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT463468 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT466677 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 4
MIRT467789 SLC2A14 solute carrier family 2 member 14 2 2
MIRT468167 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT468652 SECISBP2L SECIS binding protein 2 like 2 6
MIRT469380 RER1 retention in endoplasmic reticulum sorting receptor 1 2 2
MIRT470346 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT472418 NCKAP1 NCK associated protein 1 2 2
MIRT474612 KLF3 Kruppel like factor 3 2 2
MIRT478703 CSRNP2 cysteine and serine rich nuclear protein 2 2 2
MIRT481008 BBC3 BCL2 binding component 3 2 4
MIRT483098 TFPI tissue factor pathway inhibitor 2 2
MIRT485113 SHISA6 shisa family member 6 2 2
MIRT497533 ZNF607 zinc finger protein 607 2 2
MIRT500644 TUBB2A tubulin beta 2A class IIa 2 6
MIRT500890 STRN striatin 2 4
MIRT501900 MED13 mediator complex subunit 13 2 2
MIRT506646 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT512675 ENO4 enolase family member 4 2 2
MIRT516977 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT528754 RPS27 ribosomal protein S27 2 6
MIRT539670 ZBTB44 zinc finger and BTB domain containing 44 2 2
MIRT544129 PPIL1 peptidylprolyl isomerase like 1 2 2
MIRT546382 STOX2 storkhead box 2 2 4
MIRT562143 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568713 TMEM30B transmembrane protein 30B 2 2
MIRT571029 CENPP centromere protein P 2 2
MIRT572781 ZNF277 zinc finger protein 277 2 2
MIRT573162 SLC30A9 solute carrier family 30 member 9 2 2
MIRT609126 NUDT3 nudix hydrolase 3 2 2
MIRT609284 OAS3 2'-5'-oligoadenylate synthetase 3 2 2
MIRT613430 GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2 2
MIRT613770 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT616645 LRAT lecithin retinol acyltransferase 2 4
MIRT630892 SLC25A33 solute carrier family 25 member 33 2 2
MIRT636526 FAXC failed axon connections homolog 2 4
MIRT641394 NUBPL nucleotide binding protein like 2 2
MIRT641412 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT642528 CERS4 ceramide synthase 4 2 2
MIRT643186 HYPK huntingtin interacting protein K 2 2
MIRT647800 FRMD8 FERM domain containing 8 2 2
MIRT652150 TRIM71 tripartite motif containing 71 2 2
MIRT652602 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT661606 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT666339 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT670414 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671122 ZNF573 zinc finger protein 573 2 2
MIRT671155 ANKRD9 ankyrin repeat domain 9 2 2
MIRT671338 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT671869 ZNF429 zinc finger protein 429 2 2
MIRT671974 IKZF3 IKAROS family zinc finger 3 2 2
MIRT672064 KIAA0930 KIAA0930 2 2
MIRT672654 SLC25A16 solute carrier family 25 member 16 2 4
MIRT672673 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT672771 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672929 LRRC2 leucine rich repeat containing 2 2 2
MIRT673159 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673272 RUNDC1 RUN domain containing 1 2 2
MIRT673332 THAP1 THAP domain containing 1 2 2
MIRT673351 SLC35F6 solute carrier family 35 member F6 2 2
MIRT673667 ZNF440 zinc finger protein 440 2 2
MIRT673904 DCTN6 dynactin subunit 6 2 2
MIRT674096 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT674401 MYCBP MYC binding protein 2 2
MIRT674525 PRR23A proline rich 23A 2 2
MIRT674793 NPR1 natriuretic peptide receptor 1 2 2
MIRT674833 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 2
MIRT675066 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT675080 CCR6 C-C motif chemokine receptor 6 2 2
MIRT675126 FSD2 fibronectin type III and SPRY domain containing 2 2 2
MIRT679401 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT689229 RPS19 ribosomal protein S19 2 2
MIRT694008 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT699671 SFT2D2 SFT2 domain containing 2 2 2
MIRT706213 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706548 GJD2 gap junction protein delta 2 2 2
MIRT707418 RRP7A ribosomal RNA processing 7 homolog A 2 2
MIRT710648 GLUL glutamate-ammonia ligase 2 2
MIRT719393 NPCA1 Nasopharyngeal carcinoma 1 2 2
MIRT720166 PNPO pyridoxamine 5'-phosphate oxidase 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4708-5p Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tripterygium wilfordii Hook F sensitive tissue
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-4708-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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