miRTarBase - #MIRT667614


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pre-miRNA Information
pre-miRNA hsa-mir-452   
Genomic Coordinates chrX: 151959628 - 151959712
Synonyms MIRN452, hsa-mir-452, MIR452
Description Homo sapiens miR-452 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-452-3p
Sequence 58| CUCAUCUGCAAAGAAGUAAGUG |79
Evidence Experimental
Experiments Array-cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 X - 151959644 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757928550 3 dbSNP
rs1324216965 6 dbSNP
rs1390793899 13 dbSNP
rs899383242 17 dbSNP
rs747858567 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol LIMCH1   
Synonyms LIMCH1A, LMO7B
Description LIM and calponin homology domains 1
Transcript NM_001112717   
Other Transcripts NM_001112718 , NM_001112719 , NM_001112720 , NM_014988   
Expression
Putative miRNA Targets on LIMCH1
3'UTR of LIMCH1
(miRNA target sites are highlighted)		 
>LIMCH1|NM_001112717|3'UTR
   1 CACGGCTTTCAAGCTTCCGGATCACTCACCATTTCTTTACTGAGAGTGTCCCCTGGCAACTGCTTAACAAAATCCCAAGC
  81 TCAGGGGCTTCTCAGCATTTACCTAATTTCTGAAAGGCTCTTCTGAAAGGTGGTATCTGTTCTTTCGTAGCACAGTGTTT
 161 ATGTTTTTCCTGTTTATTGTTTTGGTTTTTTTTTTTTTTTTGCATTTGCACAGTATACACAAAAGAATATGGGGTTGTAA
 241 TGATCCTGAATAGCTCAAAAAAGGTTTTAGCATGGTCAAACAGGCTTATGGTTTAAAATGTGTTATTCTCTTCTTTGGGA
 321 ATTAGCTAAATGATGCAATAAACCTGTTTTGTTTTAGAATGTCTAGGAATTAAACACTTTATGTTTACAGAATTGAGCTG
 401 CAGAAAGTGCAAGACATGCCAATTTGAGACACACGGTCTTCTAAGACTGAAGGATAAATTTAATGCATTTCAGAAACTAA
 481 ACATCACAGCAAGCTCTATCTCTGAGCTATAATTTGTTTTTAATGCAAAGACACTAGTTTGATAATATATACTGTAATCC
 561 TGAAACATTTGTGTTACTTACCTTTGGAGGTAGAAATTATACCAATAAATTATTGCACCGTTAGTATTAGATTCTGTGTA
 641 CCTTGGAAGTTATGTCATTAATATAGGCTGGTTCATCAAATAAAGCAAAACCTTGCAATATCAGCTAGATTTACACTCCG
 721 GGACGTTGCCCAAAGGTAGGAAGAAAGCAGAGGGAAATATTTCAGTCATCATTTCCAAAGTCATTATCAAAATCTGTGAG
 801 GAAGTTTAATCTTCCAAAGAGTCAATGTCAGACATCAGGCCTCTGTTGCCTGCTTCTCTCGAGGCACTAGATTAGGAGTC
 881 TTCAATAAGAGACTTAACATGAGGTATATGGAAGATGAGGCACCGAGATAAGTTCATCATTAGGTGTGAGCACTGCTCAC
 961 CCTTGCTGGCAAGTTCTCCTTAAGGGCCTGAAGCACAGGTGTCCAAAGAAAAGCGTTAAGTCCATCTTAATAGAATCTAT
1041 GTGGTATATGATGTGGTCAGCCCCTGGTCTGTGATCAGCAAGAACCTACAGCACAGATTATGCCCTGCCCACTTCAATGA
1121 ATACCTACTCTCCTCCATTCTCCATCACTTTTTTTGCTATCAAGAACTCCGGACCTTGCCCATGGAGAAGTTTAGAGAGG
1201 AACTCTTGTGGAGAGCTGGTTTATTTTCTGCCCTGTGCGACGAGTTTCAGCTGGCCAAGAAAGGAGTCAAGTTATTAAAA
1281 AGCATCACAATGTAGATCTCCAGGCTGGTTTTTTGTTTTTTGTTGTTAAGACTGGGGAAAGGGGGACTATTTATTCTGCC
1361 TTAAATCAATGGCAAATAAGTCAAGATGACATTTTGTGAATGTAGACTATGGATACACTCCTAATAGATTGATGTAGTCA
1441 TAAAAGGGGGTCAAGTAGATGTTTTTCTGTTATGTAAGCAATAATTTTTCCGTGTCTTATTGAGTATGGCTAGCGATTAT
1521 TTATTACATGCTAGATGGGTTCTTTGCATGTGGGTTCCATATAGGTGCAGAAATTTCCTCAGCCACTGGAGGGATTTCGA
1601 CCATATTTGTCATTTGGATGAGCTGTTATTAGATTGAAATCTACACATCATTTCATTAAAAATTGTGCCTTAGAAAACGC
1681 AAAGCTGTTGCACATGGCGATAAATTATGGATGCAGTACATTGAAGAGAGATGAAGTCACTTCCAAGTTTCCAAGACTTC
1761 TCATGGAGGTGTTTGCTGTTTTACAGGAAAAAATAAAAATAAAAAAAGAAAAAAAGAAAAAATTAAAAAGAAAAATTGTT
1841 TTGAAAATGTACAGATCAAGTCCAATATTTTGATTATCCACCTGCATGTTTTATTAAATATTTTGATAATGTGGATGTTT
1921 ACACTTTGCATGATATTAGCAGAGTACCACTAGTAATGCACAAACATGTACAATATGGTCATTCATAACCGATTTTTATA
2001 GAATACTTTTTACATGTGCAACTCCATCCGTTATGTAAGGATTACATGAATATTGCACATTCCCTTCTGGTTTCACAAAC
2081 CCATTTATACATATTTCTTAGTGAGGCTCATTGTACATGTATTGAAGCTAGAATCGAGTCAAGAAAAATAAAGCCCCATT
2161 CTCCAACTGCAAAATGTGCTTTCCCATAATGAACACTAGTCACCAGCACAGAATAATCTCCAACATTTTCTAAATTCTAA
2241 TTGCCAACTGTTTCTATTTATATTTGATTTATATTTCATTTGGAGTCTGTTACATGGCAGCTTAGGCAGACTAGATCTTG
2321 TTTTTTCCAATGCAGCATAATGAGTATGATCTATTTCTTTTCAAATAATCTTTGAGATCCCAGGAAAAAAAAAATGCTCT
2401 GCTCCATTGAGCTATAATGTAAATGTGTTTGTTTAAAAAACAGGTGAGGCAAGTGAGTGATTTATTGTTCCTGAGGAAGT
2481 ATATCTGATTTTTTTTCTCATACTCCAAAAGCTAGTCCCTACTCTTTAATAAAAATAATGGGTAACTTTTTGTTTTTCAC
2561 TAGCGAACTTCCATGACATTTCCTTTCTATGTAGTGTGATTAATGCAATACATATTATAGTTATCTATACACAGTGTAAG
2641 ATTTAACAAACTGAAATGATCCACCTCATATGTGAGTCCGTCCAAAAGATGTTACTGCTCTGGGTGGGCCAGTGTTCTAT
2721 ATCGGTTATACTAACTTTCATTTAAAGTATTTATTCTAAAATGCCTCTGAGAAACAGTAAAAAATAAAAACAACAAGTTG
2801 TCTAAAATGCAACAGCTTTTATAGTAAATGTACATTTATAAATAAAATACTCAAATCAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gugaAUGAAGAAA-----CGUCUACUc 5'
              |::|| |||      |||:||| 
Target 5' aatgTGTTTGTTTAAAAAACAGGTGAg 3'
 2422 - 2448 134.00 -14.40
2 
miRNA  3' gugAAUGAAGAA---AC-GUCUACUc 5'
             |||:|| ||   || :|||||: 
Target 5' cgaTTATTTATTACATGCTAGATGGg 3'
 1514 - 1539 131.00 -13.80
3 
miRNA  3' guGAAUGA--AGAAACGUCUACUc 5'
            | ||:|  || || ::||||| 
Target 5' acCATATTTGTCATT-TGGATGAg 3'
 1600 - 1622 125.00 -10.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31497055 5 COSMIC
COSN30448705 20 COSMIC
COSN31494258 20 COSMIC
COSN30475686 30 COSMIC
COSN9040555 30 COSMIC
COSN26982464 58 COSMIC
COSN30479974 96 COSMIC
COSN30462539 143 COSMIC
COSN30465610 171 COSMIC
COSN15666937 180 COSMIC
COSN20100007 201 COSMIC
COSN18745867 202 COSMIC
COSN9790192 322 COSMIC
COSN21306893 554 COSMIC
COSN7490686 841 COSMIC
COSN32056039 1053 COSMIC
COSN6830817 1122 COSMIC
COSN1297100 1156 COSMIC
COSN32057665 1160 COSMIC
COSN31618946 1479 COSMIC
COSN31541120 1491 COSMIC
COSN26584403 1516 COSMIC
COSN5015075 1572 COSMIC
COSN32065478 1674 COSMIC
COSN25120497 1824 COSMIC
COSN6830818 1852 COSMIC
COSN32064832 1886 COSMIC
COSN20100008 1967 COSMIC
COSN2028569 2018 COSMIC
COSN28060861 2150 COSMIC
COSN2028570 2224 COSMIC
COSN2028571 2225 COSMIC
COSN2028572 2247 COSMIC
COSN20642553 2288 COSMIC
COSN32056577 2340 COSMIC
COSN20100009 2395 COSMIC
COSN27599338 2395 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1258646753 2 dbSNP
rs745995108 3 dbSNP
rs775848174 4 dbSNP
rs199843076 5 dbSNP
rs772913435 10 dbSNP
rs1184310562 11 dbSNP
rs1412618456 13 dbSNP
rs1009167271 14 dbSNP
rs1401421090 16 dbSNP
rs760488800 17 dbSNP
rs10027910 19 dbSNP
rs776698811 20 dbSNP
rs192567395 21 dbSNP
rs1313478450 25 dbSNP
rs773768102 29 dbSNP
rs764848796 30 dbSNP
rs900469365 32 dbSNP
rs1319074323 33 dbSNP
rs752189505 34 dbSNP
rs762531238 36 dbSNP
rs1223661474 37 dbSNP
rs763759852 40 dbSNP
rs757598326 45 dbSNP
rs1368539204 46 dbSNP
rs1211218290 48 dbSNP
rs116565093 51 dbSNP
rs750925529 53 dbSNP
rs1408116210 54 dbSNP
rs147991826 70 dbSNP
rs1027806565 79 dbSNP
rs1365918142 84 dbSNP
rs534976439 88 dbSNP
rs113543450 92 dbSNP
rs951804439 96 dbSNP
rs951062264 101 dbSNP
rs376269024 102 dbSNP
rs1329550339 118 dbSNP
rs971262397 133 dbSNP
rs1290255388 134 dbSNP
rs1317643781 140 dbSNP
rs1283632303 143 dbSNP
rs981754990 145 dbSNP
rs1347636163 146 dbSNP
rs554667376 147 dbSNP
rs141681359 148 dbSNP
rs1435935563 162 dbSNP
rs537580497 163 dbSNP
rs1405366148 173 dbSNP
rs1005033309 177 dbSNP
rs1291767385 180 dbSNP
rs927256374 180 dbSNP
rs1016884296 184 dbSNP
rs937169399 185 dbSNP
rs10709122 186 dbSNP
rs1176651336 186 dbSNP
rs1455129148 186 dbSNP
rs569294141 186 dbSNP
rs796561403 186 dbSNP
rs869233054 186 dbSNP
rs1364765664 187 dbSNP
rs557175358 190 dbSNP
rs1226777488 191 dbSNP
rs1213764482 197 dbSNP
rs1274415789 199 dbSNP
rs1360537534 200 dbSNP
rs1225162425 201 dbSNP
rs1325708017 202 dbSNP
rs1287373695 203 dbSNP
rs1450651589 204 dbSNP
rs1193337440 208 dbSNP
rs1223112862 209 dbSNP
rs1322623588 212 dbSNP
rs1298920683 213 dbSNP
rs1383641788 215 dbSNP
rs1243293482 216 dbSNP
rs1474402329 217 dbSNP
rs1187780465 223 dbSNP
rs1385647776 226 dbSNP
rs1432297287 234 dbSNP
rs577139866 264 dbSNP
rs1337035204 265 dbSNP
rs963587163 273 dbSNP
rs1161439582 274 dbSNP
rs1172993163 274 dbSNP
rs1429426194 280 dbSNP
rs979809219 284 dbSNP
rs185825658 285 dbSNP
rs1187191466 289 dbSNP
rs1462748547 290 dbSNP
rs1243807485 301 dbSNP
rs1203346442 306 dbSNP
rs959666375 320 dbSNP
rs992524701 328 dbSNP
rs913131772 376 dbSNP
rs1482400068 379 dbSNP
rs1253227868 381 dbSNP
rs1229373889 382 dbSNP
rs1307823285 384 dbSNP
rs915278705 389 dbSNP
rs1226057374 406 dbSNP
rs115979243 408 dbSNP
rs1315135058 409 dbSNP
rs1042382164 411 dbSNP
rs866647365 413 dbSNP
rs1399627687 417 dbSNP
rs750054954 423 dbSNP
rs925740636 435 dbSNP
rs942538028 436 dbSNP
rs944712057 438 dbSNP
rs1041022454 445 dbSNP
rs900784624 446 dbSNP
rs996713404 450 dbSNP
rs1328237980 456 dbSNP
rs1252970452 458 dbSNP
rs1027823586 459 dbSNP
rs887506727 461 dbSNP
rs1273637695 464 dbSNP
rs542625326 486 dbSNP
rs1004603827 503 dbSNP
rs1361510868 507 dbSNP
rs1315578446 510 dbSNP
rs1039069223 517 dbSNP
rs900606974 519 dbSNP
rs997458897 531 dbSNP
rs1052222111 532 dbSNP
rs1373139237 533 dbSNP
rs886691081 545 dbSNP
rs796410023 548 dbSNP
rs1034672058 551 dbSNP
rs1426878358 555 dbSNP
rs958659487 560 dbSNP
rs1005511796 563 dbSNP
rs1016519402 566 dbSNP
rs1456495353 567 dbSNP
rs914420589 571 dbSNP
rs1182877722 579 dbSNP
rs116256854 592 dbSNP
rs1249809594 593 dbSNP
rs1001717283 603 dbSNP
rs1205311890 607 dbSNP
rs1285749847 610 dbSNP
rs56688481 620 dbSNP
rs561394368 621 dbSNP
rs992493796 634 dbSNP
rs1353716369 638 dbSNP
rs912925347 641 dbSNP
rs1427329018 643 dbSNP
rs967076273 664 dbSNP
rs1222481491 673 dbSNP
rs1185205879 680 dbSNP
rs201178367 692 dbSNP
rs1367629588 696 dbSNP
rs1328061981 697 dbSNP
rs1286015097 699 dbSNP
rs1472611223 704 dbSNP
rs1407175548 707 dbSNP
rs1159301696 711 dbSNP
rs530512880 717 dbSNP
rs550296709 720 dbSNP
rs765627951 721 dbSNP
rs1049667900 723 dbSNP
rs752949213 725 dbSNP
rs975243947 726 dbSNP
rs1005034395 739 dbSNP
rs1178804167 748 dbSNP
rs563860287 749 dbSNP
rs1014625211 755 dbSNP
rs1269316365 759 dbSNP
rs532705316 760 dbSNP
rs922002952 768 dbSNP
rs906996669 772 dbSNP
rs1319930963 778 dbSNP
rs1407531117 782 dbSNP
rs561380312 783 dbSNP
rs1263688344 797 dbSNP
rs1205224470 803 dbSNP
rs1034022530 805 dbSNP
rs1265902021 807 dbSNP
rs958843549 809 dbSNP
rs1324793074 810 dbSNP
rs1011478940 811 dbSNP
rs1231440312 811 dbSNP
rs145257135 817 dbSNP
rs1328723870 820 dbSNP
rs574353344 821 dbSNP
rs778103270 823 dbSNP
rs1340173583 825 dbSNP
rs1434503566 826 dbSNP
rs552505075 827 dbSNP
rs1280987159 837 dbSNP
rs1339009362 842 dbSNP
rs566314051 846 dbSNP
rs1428774284 849 dbSNP
rs1171793785 859 dbSNP
rs747125192 862 dbSNP
rs1193766459 881 dbSNP
rs1464091973 890 dbSNP
rs1372225611 905 dbSNP
rs7674006 906 dbSNP
rs1462616379 913 dbSNP
rs940719640 920 dbSNP
rs757394093 925 dbSNP
rs1255225387 926 dbSNP
rs1438132655 932 dbSNP
rs1228293770 933 dbSNP
rs1183711594 934 dbSNP
rs921970764 940 dbSNP
rs1453388342 961 dbSNP
rs1414511585 968 dbSNP
rs1358824352 972 dbSNP
rs547698989 977 dbSNP
rs1332386041 978 dbSNP
rs1412581759 979 dbSNP
rs1471718482 982 dbSNP
rs1158545182 983 dbSNP
rs1398342909 985 dbSNP
rs1168487098 987 dbSNP
rs150543534 994 dbSNP
rs1388175930 999 dbSNP
rs1049286351 1001 dbSNP
rs909509828 1007 dbSNP
rs940854802 1009 dbSNP
rs1001684218 1014 dbSNP
rs1034554737 1015 dbSNP
rs115421177 1016 dbSNP
rs1402102133 1024 dbSNP
rs770827277 1025 dbSNP
rs1013977522 1027 dbSNP
rs1392402313 1032 dbSNP
rs1331256162 1033 dbSNP
rs1340675278 1035 dbSNP
rs781624294 1040 dbSNP
rs1027209331 1057 dbSNP
rs1002645296 1061 dbSNP
rs1020037427 1064 dbSNP
rs967427219 1067 dbSNP
rs1348296018 1068 dbSNP
rs571847682 1072 dbSNP
rs17590376 1076 dbSNP
rs1444625765 1086 dbSNP
rs1033330741 1094 dbSNP
rs1283406591 1095 dbSNP
rs116807154 1101 dbSNP
rs1368656108 1104 dbSNP
rs975214492 1105 dbSNP
rs865878302 1106 dbSNP
rs1230998820 1112 dbSNP
rs922474434 1113 dbSNP
rs1255404742 1117 dbSNP
rs1339954388 1118 dbSNP
rs1021544191 1124 dbSNP
rs1179823779 1129 dbSNP
rs1470961131 1130 dbSNP
rs1233036702 1134 dbSNP
rs933828586 1135 dbSNP
rs1181933346 1139 dbSNP
rs987936603 1146 dbSNP
rs967294346 1151 dbSNP
rs1061562 1160 dbSNP
rs1321261439 1164 dbSNP
rs1482213554 1165 dbSNP
rs1225474657 1169 dbSNP
rs748984527 1171 dbSNP
rs539582094 1172 dbSNP
rs1037729613 1184 dbSNP
rs976181557 1191 dbSNP
rs899411436 1192 dbSNP
rs1304931449 1196 dbSNP
rs922036588 1197 dbSNP
rs1349163236 1199 dbSNP
rs1435038677 1204 dbSNP
rs1174037413 1208 dbSNP
rs537005833 1217 dbSNP
rs953404501 1219 dbSNP
rs1377598075 1220 dbSNP
rs1401888933 1220 dbSNP
rs774237100 1229 dbSNP
rs1056063173 1239 dbSNP
rs188685366 1240 dbSNP
rs1014445194 1242 dbSNP
rs151089436 1243 dbSNP
rs902962567 1245 dbSNP
rs192808091 1247 dbSNP
rs1032678994 1259 dbSNP
rs1447616940 1266 dbSNP
rs1267786342 1269 dbSNP
rs1384643620 1271 dbSNP
rs1326883797 1277 dbSNP
rs963921157 1283 dbSNP
rs1284963389 1287 dbSNP
rs369082020 1288 dbSNP
rs1366845927 1289 dbSNP
rs1291671975 1290 dbSNP
rs1299957445 1291 dbSNP
rs1326974870 1296 dbSNP
rs1229463278 1297 dbSNP
rs1272212521 1301 dbSNP
rs1388694682 1301 dbSNP
rs1319539657 1303 dbSNP
rs1341122032 1305 dbSNP
rs1455316632 1305 dbSNP
rs1430894429 1306 dbSNP
rs1055546083 1309 dbSNP
rs1432920552 1316 dbSNP
rs1029552773 1343 dbSNP
rs955179103 1345 dbSNP
rs1450222918 1348 dbSNP
rs554928184 1351 dbSNP
rs374174135 1371 dbSNP
rs1206827654 1378 dbSNP
rs907932125 1383 dbSNP
rs1042744728 1402 dbSNP
rs1489570717 1404 dbSNP
rs1210594626 1405 dbSNP
rs1311357627 1409 dbSNP
rs903077652 1413 dbSNP
rs962190796 1415 dbSNP
rs998783692 1422 dbSNP
rs1296236808 1424 dbSNP
rs973802318 1427 dbSNP
rs1189595640 1430 dbSNP
rs1019574296 1432 dbSNP
rs1465891711 1441 dbSNP
rs1429663046 1442 dbSNP
rs543819767 1443 dbSNP
rs1430950303 1460 dbSNP
rs555406296 1463 dbSNP
rs761362718 1472 dbSNP
rs937325621 1478 dbSNP
rs1186777576 1481 dbSNP
rs747284209 1482 dbSNP
rs1257172916 1488 dbSNP
rs997126304 1490 dbSNP
rs184304218 1492 dbSNP
rs917520613 1493 dbSNP
rs1206950818 1501 dbSNP
rs532888250 1511 dbSNP
rs950253306 1515 dbSNP
rs546373215 1516 dbSNP
rs902930339 1521 dbSNP
rs376642898 1539 dbSNP
rs1273771055 1548 dbSNP
rs999983049 1550 dbSNP
rs1384327416 1560 dbSNP
rs1054141369 1562 dbSNP
rs899484666 1564 dbSNP
rs1456014066 1575 dbSNP
rs996480790 1578 dbSNP
rs1395080837 1581 dbSNP
rs138814699 1588 dbSNP
rs1300278427 1597 dbSNP
rs1430745361 1599 dbSNP
rs1370518639 1600 dbSNP
rs1167226856 1604 dbSNP
rs1426674667 1613 dbSNP
rs1369111482 1616 dbSNP
rs567445975 1618 dbSNP
rs1004449029 1619 dbSNP
rs928919301 1624 dbSNP
rs938854837 1626 dbSNP
rs1015459568 1630 dbSNP
rs1364366099 1631 dbSNP
rs947136155 1635 dbSNP
rs962868879 1638 dbSNP
rs1042715129 1641 dbSNP
rs757388337 1645 dbSNP
rs534958221 1651 dbSNP
rs1308642016 1655 dbSNP
rs1316863082 1658 dbSNP
rs1410872215 1664 dbSNP
rs934340537 1676 dbSNP
rs1040966934 1679 dbSNP
rs1219599484 1683 dbSNP
rs528764907 1686 dbSNP
rs958668380 1699 dbSNP
rs760378257 1700 dbSNP
rs765900370 1702 dbSNP
rs1160144901 1717 dbSNP
rs1246800834 1725 dbSNP
rs1408418754 1733 dbSNP
rs1472824852 1746 dbSNP
rs996659263 1752 dbSNP
rs1180011546 1756 dbSNP
rs1028577818 1763 dbSNP
rs1267911447 1769 dbSNP
rs991517660 1776 dbSNP
rs889184042 1780 dbSNP
rs1487201025 1782 dbSNP
rs548925362 1787 dbSNP
rs1269682261 1788 dbSNP
rs568794884 1792 dbSNP
rs1016325358 1794 dbSNP
rs1184612230 1795 dbSNP
rs1225760194 1801 dbSNP
rs1286849981 1801 dbSNP
rs77567988 1801 dbSNP
rs972072454 1803 dbSNP
rs1323433208 1808 dbSNP
rs1064973 1809 dbSNP
rs960568928 1809 dbSNP
rs1387209294 1811 dbSNP
rs991647055 1814 dbSNP
rs577795704 1815 dbSNP
rs796625214 1816 dbSNP
rs112048741 1817 dbSNP
rs947564130 1818 dbSNP
rs936169735 1823 dbSNP
rs978490180 1825 dbSNP
rs1458418874 1829 dbSNP
rs1054104290 1831 dbSNP
rs1431009622 1838 dbSNP
rs899620625 1839 dbSNP
rs934308945 1854 dbSNP
rs996449556 1861 dbSNP
rs539595142 1862 dbSNP
rs1041119645 1864 dbSNP
rs901050776 1865 dbSNP
rs932580412 1885 dbSNP
rs764746944 1888 dbSNP
rs1453225214 1892 dbSNP
rs888268295 1907 dbSNP
rs1298429443 1912 dbSNP
rs147411290 1915 dbSNP
rs1363323832 1924 dbSNP
rs1336366716 1927 dbSNP
rs1037741546 1930 dbSNP
rs1402626772 1934 dbSNP
rs897921784 1951 dbSNP
rs891028124 1953 dbSNP
rs1036116215 1956 dbSNP
rs200583022 1966 dbSNP
rs751800298 1966 dbSNP
rs1013571377 1967 dbSNP
rs139719703 1969 dbSNP
rs1004097263 1970 dbSNP
rs1015927029 1972 dbSNP
rs1443415464 1974 dbSNP
rs898302749 1981 dbSNP
rs968873541 1986 dbSNP
rs995355762 1990 dbSNP
rs80151652 1991 dbSNP
rs781429787 1992 dbSNP
rs1275914791 1995 dbSNP
rs991486356 2001 dbSNP
rs1227814555 2018 dbSNP
rs924325394 2019 dbSNP
rs1286231855 2022 dbSNP
rs377462368 2025 dbSNP
rs189878384 2030 dbSNP
rs977662980 2031 dbSNP
rs976422139 2034 dbSNP
rs1266259286 2035 dbSNP
rs922275375 2036 dbSNP
rs1169112288 2037 dbSNP
rs1428607237 2038 dbSNP
rs1387775312 2040 dbSNP
rs932364780 2041 dbSNP
rs386673893 2045 dbSNP
rs76961450 2046 dbSNP
rs76405436 2047 dbSNP
rs1484222440 2054 dbSNP
rs990300935 2057 dbSNP
rs1181634197 2065 dbSNP
rs1205058394 2069 dbSNP
rs780096489 2076 dbSNP
rs1340213948 2077 dbSNP
rs921008459 2084 dbSNP
rs557375359 2086 dbSNP
rs1228901965 2090 dbSNP
rs897887595 2092 dbSNP
rs1282600288 2098 dbSNP
rs778569654 2100 dbSNP
rs577655617 2114 dbSNP
rs867756326 2116 dbSNP
rs1308625146 2118 dbSNP
rs1050807473 2122 dbSNP
rs1470260315 2123 dbSNP
rs1352624076 2132 dbSNP
rs1405395741 2133 dbSNP
rs890756564 2136 dbSNP
rs939697657 2137 dbSNP
rs1162315904 2148 dbSNP
rs181033451 2168 dbSNP
rs879024013 2173 dbSNP
rs561377567 2180 dbSNP
rs1023216993 2197 dbSNP
rs1357349684 2208 dbSNP
rs768313913 2210 dbSNP
rs574046228 2219 dbSNP
rs1000329261 2230 dbSNP
rs1451075075 2233 dbSNP
rs1288055635 2255 dbSNP
rs995323163 2257 dbSNP
rs1033553941 2261 dbSNP
rs955787976 2272 dbSNP
rs894557044 2275 dbSNP
rs528651621 2278 dbSNP
rs1351393591 2280 dbSNP
rs976896752 2284 dbSNP
rs1436632711 2286 dbSNP
rs573445163 2290 dbSNP
rs1012972855 2295 dbSNP
rs1286569237 2296 dbSNP
rs1348778230 2298 dbSNP
rs922401681 2305 dbSNP
rs866333596 2310 dbSNP
rs1328518766 2321 dbSNP
rs1024813387 2324 dbSNP
rs542460454 2331 dbSNP
rs1427912772 2340 dbSNP
rs1192262061 2343 dbSNP
rs1477774965 2345 dbSNP
rs1251216050 2347 dbSNP
rs1281402940 2348 dbSNP
rs1310952926 2357 dbSNP
rs909763352 2363 dbSNP
rs1267691086 2373 dbSNP
rs1233752963 2377 dbSNP
rs1483834563 2378 dbSNP
rs1207913722 2385 dbSNP
rs369358100 2385 dbSNP
rs371782469 2385 dbSNP
rs562331406 2386 dbSNP
rs531237108 2400 dbSNP
rs1300642320 2407 dbSNP
rs1436579644 2408 dbSNP
rs778879342 2412 dbSNP
rs1319430390 2415 dbSNP
rs1250451699 2418 dbSNP
rs1452144178 2421 dbSNP
rs115644168 2442 dbSNP
rs1192395997 2452 dbSNP
rs1414407959 2454 dbSNP
rs1031903974 2462 dbSNP
rs957655692 2468 dbSNP
rs1393747829 2477 dbSNP
rs1190620508 2481 dbSNP
rs1450122729 2483 dbSNP
rs1184983301 2489 dbSNP
rs1484808556 2489 dbSNP
rs375708194 2489 dbSNP
rs1413823409 2497 dbSNP
rs1210489677 2500 dbSNP
rs1311551448 2501 dbSNP
rs1278046410 2508 dbSNP
rs1230024002 2513 dbSNP
rs1342222388 2516 dbSNP
rs1296493110 2518 dbSNP
rs990269843 2519 dbSNP
rs921396471 2530 dbSNP
rs1372138070 2538 dbSNP
rs939221342 2542 dbSNP
rs1374208027 2546 dbSNP
rs34067601 2547 dbSNP
rs1431889372 2551 dbSNP
rs1306460460 2559 dbSNP
rs564363898 2560 dbSNP
rs986541455 2565 dbSNP
rs532719132 2566 dbSNP
rs1437364698 2572 dbSNP
rs1257057656 2574 dbSNP
rs533451875 2583 dbSNP
rs1366131814 2584 dbSNP
rs1255377643 2588 dbSNP
rs1044421771 2592 dbSNP
rs1483136510 2593 dbSNP
rs1250272981 2619 dbSNP
rs1224539381 2626 dbSNP
rs939692125 2627 dbSNP
rs546808216 2631 dbSNP
rs1062144 2632 dbSNP
rs1228154121 2637 dbSNP
rs898410767 2646 dbSNP
rs1344695872 2647 dbSNP
rs1310458236 2648 dbSNP
rs931254537 2650 dbSNP
rs1410975560 2661 dbSNP
rs1055056112 2662 dbSNP
rs1296541077 2664 dbSNP
rs1459472682 2677 dbSNP
rs1369311768 2680 dbSNP
rs772733500 2681 dbSNP
rs1273516974 2691 dbSNP
rs894941285 2692 dbSNP
rs1031958379 2695 dbSNP
rs535230250 2704 dbSNP
rs1183998016 2710 dbSNP
rs1490409441 2720 dbSNP
rs1249673241 2721 dbSNP
rs1013444379 2724 dbSNP
rs998397335 2725 dbSNP
rs1265717342 2726 dbSNP
rs184407196 2727 dbSNP
rs1045802427 2728 dbSNP
rs1332123297 2729 dbSNP
rs1229337055 2730 dbSNP
rs907304757 2731 dbSNP
rs1244410396 2733 dbSNP
rs998863555 2739 dbSNP
rs1388646764 2748 dbSNP
rs1032123287 2755 dbSNP
rs1016565840 2764 dbSNP
rs749631813 2765 dbSNP
rs1293223986 2768 dbSNP
rs1460077927 2769 dbSNP
rs962379662 2771 dbSNP
rs60815093 2776 dbSNP
rs563325587 2778 dbSNP
rs1363200634 2779 dbSNP
rs918541581 2779 dbSNP
rs939175276 2783 dbSNP
rs992015449 2786 dbSNP
rs758004478 2789 dbSNP
rs1192395154 2791 dbSNP
rs1167724639 2792 dbSNP
rs917283766 2794 dbSNP
rs1209792502 2795 dbSNP
rs1350381766 2796 dbSNP
rs1259542262 2816 dbSNP
rs1011743777 2821 dbSNP
rs530670531 2822 dbSNP
rs1332116242 2830 dbSNP
rs1302786157 2834 dbSNP
rs1044389342 2836 dbSNP
rs757332577 2839 dbSNP
rs1367660082 2844 dbSNP
rs1325614327 2851 dbSNP
rs1321433717 2852 dbSNP
rs1348159225 2854 dbSNP
rs1383958935 2858 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000313860.7 | 3UTR | UGAAGAGAGAUGAAGUCACUUCCAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.93 2.1e-6 0.923 3.4e-6 13 Click to see details
GSE28544 Breast cancer 0.527 4.1e-3 0.567 1.9e-3 24 Click to see details
GSE32688 Pancreatic cancer 0.35 2.5e-2 0.367 1.9e-2 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.289 8.1e-2 -0.415 2.0e-2 25 Click to see details
GSE26953 Aortic valvular endothelial cells 0.269 1.0e-1 0.170 2.1e-1 24 Click to see details
GSE38226 Liver fibrosis 0.211 1.8e-1 0.106 3.2e-1 21 Click to see details
GSE17306 Multiple myeloma 0.125 2.0e-1 0.513 8.2e-5 49 Click to see details
GSE17498 Multiple myeloma 0.134 2.0e-1 -0.040 4.0e-1 40 Click to see details
GSE42095 Differentiated embryonic stem cells -0.113 3.0e-1 -0.095 3.3e-1 23 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.072 3.8e-1 -0.338 7.2e-2 20 Click to see details
GSE19350 CNS germ cell tumors 0.082 4.0e-1 0.448 7.2e-2 12 Click to see details
GSE21687 Ependynoma primary tumors 0.027 4.2e-1 -0.003 4.9e-1 64 Click to see details
GSE14794 Lymphoblastoid cells -0.002 4.9e-1 -0.027 4.0e-1 90 Click to see details
GSE27834 Pluripotent stem cells 0.002 5.0e-1 -0.194 2.4e-1 16 Click to see details
GSE27834 Pluripotent stem cells 0.002 5.0e-1 -0.194 2.4e-1 16 Click to see details
GSE27834 Pluripotent stem cells 0.002 5.0e-1 -0.194 2.4e-1 16 Click to see details
GSE27834 Pluripotent stem cells 0.002 5.0e-1 -0.194 2.4e-1 16 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUAD -0.63 0.02 -0.636 0.02 11 Click to see details
KIRC -0.207 0.05 -0.171 0.09 65 Click to see details
LUSC -0.225 0.09 -0.171 0.15 38 Click to see details
HNSC -0.191 0.11 -0.211 0.09 42 Click to see details
PAAD 0.75 0.13 0.400 0.3 4 Click to see details
KICH 0.236 0.13 0.288 0.09 24 Click to see details
BRCA 0.125 0.14 0.083 0.23 79 Click to see details
STAD 0.204 0.14 0.046 0.41 29 Click to see details
THCA 0.118 0.19 0.062 0.32 59 Click to see details
ESCA -0.337 0.19 -0.350 0.18 9 Click to see details
CHOL 0.289 0.23 0.183 0.32 9 Click to see details
LIHC -0.11 0.23 -0.113 0.22 49 Click to see details
UCEC 0.167 0.25 0.170 0.24 19 Click to see details
KIRP 0.116 0.27 0.117 0.27 31 Click to see details
BLCA 0.046 0.43 -0.373 0.07 17 Click to see details
PRAD 0.005 0.49 -0.067 0.33 48 Click to see details
PRAD 0.005 0.49 -0.067 0.33 48 Click to see details
PRAD 0.005 0.49 -0.067 0.33 48 Click to see details
CESC 1 0.5 1.000 0.5 3 Click to see details
CESC 1 0.5 1.000 0.5 3 Click to see details
87 hsa-miR-452-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT150000 MIDN midnolin 2 10
MIRT330600 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT358701 SUB1 SUB1 homolog, transcriptional regulator 2 4
MIRT362854 EIF4H eukaryotic translation initiation factor 4H 2 2
MIRT447215 ATXN7 ataxin 7 2 2
MIRT466655 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT483979 PANK1 pantothenate kinase 1 2 8
MIRT485118 SF3B3 splicing factor 3b subunit 3 2 2
MIRT488864 AUTS8 Autism, susceptibility to, 8 2 2
MIRT492293 SH2B3 SH2B adaptor protein 3 2 2
MIRT492976 NCK2 NCK adaptor protein 2 2 2
MIRT497410 LRRC40 leucine rich repeat containing 40 2 2
MIRT511143 MRPL17 mitochondrial ribosomal protein L17 2 6
MIRT512650 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT513017 NSFL1C NSFL1 cofactor 2 6
MIRT520445 TSPAN2 tetraspanin 2 2 6
MIRT527995 NDNF neuron derived neurotrophic factor 2 2
MIRT528667 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT533512 TRIM71 tripartite motif containing 71 2 2
MIRT537404 FBXO47 F-box protein 47 2 2
MIRT538161 DCP2 decapping mRNA 2 2 2
MIRT539124 ARHGEF17 Rho guanine nucleotide exchange factor 17 2 2
MIRT540666 MIS18A MIS18 kinetochore protein A 2 4
MIRT542948 GDF11 growth differentiation factor 11 2 2
MIRT547534 MAML3 mastermind like transcriptional coactivator 3 2 2
MIRT559033 C20orf24 chromosome 20 open reading frame 24 2 4
MIRT559554 ARF6 ADP ribosylation factor 6 2 2
MIRT570177 RCBTB1 RCC1 and BTB domain containing protein 1 2 2
MIRT573149 ITGA9 integrin subunit alpha 9 2 2
MIRT575849 Rab1 RAB1A, member RAS oncogene family 1 1
MIRT611034 RRP1B ribosomal RNA processing 1B 2 2
MIRT616281 HMGB1 high mobility group box 1 2 2
MIRT618372 PRKG2 protein kinase, cGMP-dependent, type II 2 2
MIRT619540 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT622303 SGIP1 SH3 domain GRB2 like endophilin interacting protein 1 2 2
MIRT622590 PRRG4 proline rich and Gla domain 4 2 2
MIRT624441 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT637089 KLRD1 killer cell lectin like receptor D1 2 2
MIRT639084 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT639334 NINJ1 ninjurin 1 2 2
MIRT639798 EIF3E eukaryotic translation initiation factor 3 subunit E 2 2
MIRT640851 RAB3B RAB3B, member RAS oncogene family 2 2
MIRT641628 KIAA1244 ARFGEF family member 3 1 1
MIRT642634 EPPIN epididymal peptidase inhibitor 2 2
MIRT643053 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643416 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT645586 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT647393 FAM181B family with sequence similarity 181 member B 2 2
MIRT649411 CDC14B cell division cycle 14B 2 2
MIRT649477 CLDN16 claudin 16 2 2
MIRT651307 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT651387 ZBTB16 zinc finger and BTB domain containing 16 2 2
MIRT653411 SLC7A2 solute carrier family 7 member 2 2 2
MIRT654084 RSPH4A radial spoke head 4 homolog A 2 2
MIRT654613 PTPRM protein tyrosine phosphatase, receptor type M 2 2
MIRT655338 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT656173 MRPL44 mitochondrial ribosomal protein L44 2 2
MIRT657272 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 2
MIRT657881 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT659875 CAPRIN1 cell cycle associated protein 1 2 2
MIRT662381 ICA1L islet cell autoantigen 1 like 2 4
MIRT666308 SLC22A3 solute carrier family 22 member 3 2 2
MIRT667274 NAV1 neuron navigator 1 2 2
MIRT667614 LIMCH1 LIM and calponin homology domains 1 2 2
MIRT674242 NUP62 nucleoporin 62 2 4
MIRT690386 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT693402 NUDT16 nudix hydrolase 16 2 2
MIRT702503 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT708632 STMN4 stathmin 4 2 2
MIRT708839 SCAND3 zinc finger BED-type containing 9 1 1
MIRT709016 HSBP1 heat shock factor binding protein 1 2 2
MIRT709235 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT710885 PARL presenilin associated rhomboid like 2 2
MIRT712262 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712573 ATP2B4 ATPase plasma membrane Ca2+ transporting 4 2 2
MIRT715046 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT718905 GALR1 galanin receptor 1 2 2
MIRT719368 FEM1A fem-1 homolog A 2 2
MIRT719495 SEC24B SEC24 homolog B, COPII coat complex component 2 2
MIRT719601 PRKX protein kinase, X-linked 2 2
MIRT719891 RRP36 ribosomal RNA processing 36 2 2
MIRT720063 ZNF449 zinc finger protein 449 2 2
MIRT721679 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT721724 VTI1A vesicle transport through interaction with t-SNAREs 1A 2 2
MIRT723370 ZNF470 zinc finger protein 470 2 2
MIRT724941 TXNL1 thioredoxin like 1 2 2
MIRT725302 NLRC5 NLR family CARD domain containing 5 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-452 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-452 Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice liver 20145010 2010 up-regulated
miR-452 Tert-butyl hydroperoxide (t-BHP) NULL 6410 Microarray mouse auditory cells 20510889 2010 down-regulated
miR-452 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CP20)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-mir-452 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-452-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-452-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-452-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (HCT8)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-452-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-452-3p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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