miRTarBase - #MIRT668304


—
pre-miRNA Information
pre-miRNA hsa-mir-4281   
Genomic Coordinates chr5: 176629439 - 176629500
Description Homo sapiens miR-4281 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4281
Sequence 35| GGGUCCCGGGGAGGGGGG |52
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs921488943 1 dbSNP
rs1040286402 3 dbSNP
rs1375541904 8 dbSNP
rs759166911 12 dbSNP
rs768735686 13 dbSNP
rs746495416 14 dbSNP
rs779751131 18 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FOSL2   
Synonyms FRA2
Description FOS like 2, AP-1 transcription factor subunit
Transcript NM_005253   
Expression
Putative miRNA Targets on FOSL2
3'UTR of FOSL2
(miRNA target sites are highlighted)		 
>FOSL2|NM_005253|3'UTR
   1 CCCAGTGCACCTCCCTCCCCAGCTCCGGAGGGGGTCCTCCTCGCTCCTCCTTCCCAGGGACCAGCACCTTCAAGCGCTCC
  81 AGGGCCGTGAGGGCAAGAGGGGGACCTGCCACCAGGGAGCTTCCTGGCTCTGGGGGACCCAGGTGGGACTTAGCAGTGAG
 161 TATTGGAAGACTTGGGTTGATCTCTTAGAAGCCATGGGACCTCCTCCCTCATTCATCTTGCAAGCAAATCCCATTTCTTG
 241 AAAAGCCTTGGAGAACTCGGTTTGGTAGACTTGGACATCTCTCTGGCTTCTGAAGAGCCTGAAGCTGGCCTGGACCATTC
 321 CTGTCCCTTTGTTACCATACTGTCTCTGGAGTGATGGTGTCCTTCCCTGCCCCACCACGCATGCTCAGTGCCTTTTGGTT
 401 TCACCTTCCCTCGACTTGACCCTTTCCTCCCCCAGCGTCAGTTTCACTCCCTCTTGGTTTTTATCAAATTTGCCATGACA
 481 TTTCATCTGGGTGGTCTGAATATTAAAGCTCTTCATTTCTGGAGATGGGGCAGCAGGTGGCTCTTCTGCTGGGGCTGACT
 561 TGTCCAGAAGGGGACAAAGTGCAATACAGAGCCTTCCCTACCCTGACGCCTCCCAGTCATCATCTCCAGAACTCCCAGCG
 641 GGGCTCCCTGAGCTCTCAAGGAGATGCTGCCATCACTGGGAGGCTCAGAGGACCCTTCCTGCCCACCTTCGGAGACGGCT
 721 TCTGGAGGAACGGCTTGGCCAGAAGACAGGGTGTGAGTGAGACAGTGGGGCACAGGTTGGGTTTGCCAAACGCCTAATTA
 801 CCAGGCCAGGAAGCATGCCAACAAAGCCACACGGGTGTCCTAGCCAGCTTCCCTTCACCTGGTGTCTTGAGTAGGGCGTC
 881 TCCTGTAATTACTGCCTTGCCATTCTGCCCCTGGACCCTTCTCTCCGGACCAGGGAGGCGTCCCTCCCTAGGAGCCACAC
 961 ATTATACTCCAAGTCCCTGCCGGGCTCCGCCTTTCCCCCACCCTGGCTCTCAGGGTGACGCCACCCACAGAGATTTAATG
1041 AGCGTGGGCCTGGACCTTCCCCAGATGCTGCCAGGCAGCCCCTCCCCAAGCCTCAAAGAAGCATTTGCTGAGGATGGAGA
1121 GGCAGGGGAGGGAGGCGGGAGGCCGTCACTGGAGTGGCGTCTGCAGCAGCTGCTGCCCCAGCACCCGCTCAGCCTGTCCT
1201 GGCTGCTCACCTCCCCGCAGGGCACCGGGCCTTTCCTGCCCTCTGTGGTCATCTGCCACCTGCTGGATCAAGTGCTTTCT
1281 CTTTTACACTCCCCTGTCCCCACCCCAGTGCACTCTTCTGGCCCAGGCAGCAAGCAAGCTGTGAACAGCTGGCCTGAGCT
1361 GTCGCTGTGGCTTGTGGCTCATGCGCCATTCCTGGTTGTCTGTTGAATCTTTCTGGCTGCTGGAATTGGAGATAGGATGT
1441 TTTGCTTCCCACTGCAGGAGAGCTGCCCCCTTTCACGGGGTTGGGGAAGGGTCCCCCTGGCCTCCAGCAGGAGCACAGCT
1521 CAGCAGGGTCCCTGCTGCCCACCCCTCTGAGCCTTTTCTCCCCAGGGTATGGCTCCTGCTGAGTTTCTTGTCCAGCAGGG
1601 CCTTGACAGGAATCCAGGGAGTAGCTCCTGGCCAGAACCAGCCTCTGCGGGGCTTGTGCTCTGCAAAGACTCTGCTGCTG
1681 GGGATTCAGCTCTAGAGGTCACAGTATCCTCGTTTGAAAGATAATTAAGATCCCCCGTGGAGAAAGCAGTGACACATTCA
1761 CACAGCTGTTCCCTCGCATGTTATTTCATGAACATGACCTGTTTTCGTGCACTAGACACACAGAGTGGAACAGCCGTATG
1841 CTTAAAGTACATGGGCCAGTGGGACTGGAAGTGACCTGTACAAGTGATGCAGAAAGGAGGGTTTCAAAGAAAAAGGATTT
1921 TGTTTAAAATACTTTAAAAATGTTATTTCCTGCATCCCTTGGCTGTGATGCCCCTCTCCCGATTTCCCAGGGGCTCTGGG
2001 AGGGACCCTTCTAAGAAGATTGGGCAGTTGGGTTTCTGGCTTGAGATGAATCCAAGCAGCAGAATGAGCCAGGAGTAGCA
2081 GGAGATGGGCAAAGAAAACTGGGGTGCACTCAGCTCTCACAGGGGTAATCATCTCAAGTGGTATTTGTAGCCAAGTGGGA
2161 GCTATTTTCTTTTTTGTGCATATAGATATTTCTTAAATGAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ggGGGGAGGGGCCCUGGg 5'
            :||:|||| |||||| 
Target 5' ccTCCTTCCCAGGGACCa 3'
 46 - 63 140.00 -31.60
2 
miRNA  3' ggGGGGA-----GGGGCCCUGGg 5'
            |:|:|     || :|||||| 
Target 5' atCTCTTAGAAGCCATGGGACCt 3'
 180 - 202 132.00 -19.80
3 
miRNA  3' ggGGGGAG-GGGCCCUGGg 5'
            |||:|| |:| ||||| 
Target 5' gaCCCTTCTCTCCGGACCa 3'
 914 - 932 132.00 -30.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30485515 14 COSMIC
COSN30498949 17 COSMIC
COSN31496949 18 COSMIC
COSN26641812 23 COSMIC
COSN30148400 26 COSMIC
COSN30474409 41 COSMIC
COSN26976630 44 COSMIC
COSN7243988 60 COSMIC
COSN31492527 66 COSMIC
COSN7243989 74 COSMIC
COSN30535389 76 COSMIC
COSN20074386 89 COSMIC
COSN23876830 254 COSMIC
COSN20090508 742 COSMIC
COSN4803632 831 COSMIC
COSN28201558 1050 COSMIC
COSN25009318 1397 COSMIC
COSN21371512 1420 COSMIC
COSN25434761 1621 COSMIC
COSN9369430 1762 COSMIC
COSN20585779 1777 COSMIC
COSN7802054 1879 COSMIC
COSN21192841 1936 COSMIC
COSN24993504 2185 COSMIC
COSN29997032 2359 COSMIC
COSN16702710 2530 COSMIC
COSN23485098 2704 COSMIC
COSN17755588 2968 COSMIC
COSN27061953 3414 COSMIC
COSN6177671 3908 COSMIC
COSN1834833 3920 COSMIC
COSN29245777 4745 COSMIC
rs7562 426 GWAS
rs2279990 1426 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1369727920 5 dbSNP
rs780871670 7 dbSNP
rs1391089269 8 dbSNP
rs559659681 10 dbSNP
rs377353016 11 dbSNP
rs774796016 12 dbSNP
rs1210447755 14 dbSNP
rs746278488 21 dbSNP
rs1334136181 23 dbSNP
rs772631018 24 dbSNP
rs912024728 26 dbSNP
rs199858036 27 dbSNP
rs374763277 28 dbSNP
rs762943930 30 dbSNP
rs1271368908 32 dbSNP
rs1247758206 33 dbSNP
rs11884725 34 dbSNP
rs776723974 35 dbSNP
rs1467807553 38 dbSNP
rs761957981 43 dbSNP
rs765460511 44 dbSNP
rs750212971 45 dbSNP
rs1391467424 46 dbSNP
rs1369430427 47 dbSNP
rs762694247 50 dbSNP
rs1166371688 51 dbSNP
rs1180678651 61 dbSNP
rs1472457083 65 dbSNP
rs764133183 68 dbSNP
rs1417727980 72 dbSNP
rs773188322 76 dbSNP
rs373955920 77 dbSNP
rs1253895697 79 dbSNP
rs1202410416 80 dbSNP
rs1345959777 83 dbSNP
rs1404108701 85 dbSNP
rs904758186 86 dbSNP
rs1273356671 87 dbSNP
rs187515659 88 dbSNP
rs1000475229 92 dbSNP
rs1224412672 96 dbSNP
rs113836379 100 dbSNP
rs1056669727 101 dbSNP
rs760598702 103 dbSNP
rs766159790 104 dbSNP
rs1157551361 106 dbSNP
rs1457240382 114 dbSNP
rs1369398579 117 dbSNP
rs1167275206 118 dbSNP
rs1422438648 121 dbSNP
rs896304426 139 dbSNP
rs1182619366 146 dbSNP
rs970514351 155 dbSNP
rs1249386385 156 dbSNP
rs939956107 161 dbSNP
rs1036947514 167 dbSNP
rs1002006014 173 dbSNP
rs1349799492 175 dbSNP
rs1265970446 194 dbSNP
rs1246668662 195 dbSNP
rs1033547749 201 dbSNP
rs898197125 207 dbSNP
rs995136224 215 dbSNP
rs1436143707 216 dbSNP
rs1028095656 221 dbSNP
rs1318688699 224 dbSNP
rs1171670240 233 dbSNP
rs1244623568 237 dbSNP
rs889505224 240 dbSNP
rs1470934413 259 dbSNP
rs1391997793 260 dbSNP
rs552649862 266 dbSNP
rs1456667121 292 dbSNP
rs1379212318 298 dbSNP
rs1368300020 306 dbSNP
rs1162497894 310 dbSNP
rs1449764850 311 dbSNP
rs1391464181 317 dbSNP
rs570936507 318 dbSNP
rs534839799 326 dbSNP
rs1445952499 327 dbSNP
rs1019555087 338 dbSNP
rs966236128 343 dbSNP
rs988389653 347 dbSNP
rs1366103466 354 dbSNP
rs1021130700 358 dbSNP
rs1211620295 367 dbSNP
rs1290849989 369 dbSNP
rs1229396296 376 dbSNP
rs146306617 379 dbSNP
rs1295683063 380 dbSNP
rs1226727612 388 dbSNP
rs968026018 391 dbSNP
rs1326083081 404 dbSNP
rs950415023 413 dbSNP
rs754683509 414 dbSNP
rs7562 426 dbSNP
rs1356526828 432 dbSNP
rs938121241 437 dbSNP
rs190811106 438 dbSNP
rs1279155589 439 dbSNP
rs1377739168 450 dbSNP
rs917781915 452 dbSNP
rs939827538 464 dbSNP
rs1431428527 467 dbSNP
rs115925640 468 dbSNP
rs1316367414 478 dbSNP
rs898375487 486 dbSNP
rs138100767 488 dbSNP
rs1049452609 492 dbSNP
rs1208460996 504 dbSNP
rs1195493566 506 dbSNP
rs758032230 512 dbSNP
rs926180207 525 dbSNP
rs184763141 537 dbSNP
rs1289562821 543 dbSNP
rs754680329 544 dbSNP
rs1438725816 555 dbSNP
rs1412013610 566 dbSNP
rs1349076662 574 dbSNP
rs545373943 576 dbSNP
rs1204830563 580 dbSNP
rs1237185240 581 dbSNP
rs557369074 582 dbSNP
rs902018146 588 dbSNP
rs1184843693 589 dbSNP
rs1009653607 592 dbSNP
rs1464110036 593 dbSNP
rs1428462597 599 dbSNP
rs1182837641 602 dbSNP
rs117257740 603 dbSNP
rs539923454 608 dbSNP
rs1001057386 609 dbSNP
rs1443267860 616 dbSNP
rs1034117709 620 dbSNP
rs959397988 628 dbSNP
rs1322949149 630 dbSNP
rs992685609 638 dbSNP
rs1398305088 639 dbSNP
rs917973896 640 dbSNP
rs1033929351 641 dbSNP
rs1279398266 645 dbSNP
rs1449234330 654 dbSNP
rs961200838 662 dbSNP
rs899005603 665 dbSNP
rs561824673 673 dbSNP
rs1337422563 675 dbSNP
rs1335813799 684 dbSNP
rs1449768158 695 dbSNP
rs1404783830 696 dbSNP
rs1382722340 698 dbSNP
rs972533063 707 dbSNP
rs1159773289 709 dbSNP
rs189093820 711 dbSNP
rs931243024 712 dbSNP
rs542451415 717 dbSNP
rs149119794 718 dbSNP
rs747588771 719 dbSNP
rs1460906514 720 dbSNP
rs1214340748 731 dbSNP
rs780850361 732 dbSNP
rs1041196373 735 dbSNP
rs1284189885 738 dbSNP
rs891525426 742 dbSNP
rs1009702856 749 dbSNP
rs1012126293 753 dbSNP
rs1285567057 757 dbSNP
rs974551364 758 dbSNP
rs1243368428 759 dbSNP
rs1381396950 761 dbSNP
rs1205051914 765 dbSNP
rs1042560697 767 dbSNP
rs1320708247 769 dbSNP
rs926081285 774 dbSNP
rs904010113 792 dbSNP
rs1317588513 793 dbSNP
rs1001109759 794 dbSNP
rs1441313962 802 dbSNP
rs936186830 806 dbSNP
rs7601241 814 dbSNP
rs959644411 816 dbSNP
rs1013547673 822 dbSNP
rs1190518701 833 dbSNP
rs1025498294 834 dbSNP
rs1475625169 836 dbSNP
rs1045690021 844 dbSNP
rs1453653670 845 dbSNP
rs1421795915 851 dbSNP
rs905914095 854 dbSNP
rs552589697 857 dbSNP
rs781501023 869 dbSNP
rs961484081 874 dbSNP
rs972795848 878 dbSNP
rs7601341 879 dbSNP
rs752272540 883 dbSNP
rs1437193485 884 dbSNP
rs746273170 894 dbSNP
rs952516763 902 dbSNP
rs1327475284 903 dbSNP
rs994693634 912 dbSNP
rs1026594565 916 dbSNP
rs1371357895 918 dbSNP
rs1399787393 922 dbSNP
rs574883018 927 dbSNP
rs1008855160 928 dbSNP
rs1479323280 937 dbSNP
rs1245494833 939 dbSNP
rs1315705458 940 dbSNP
rs7601357 941 dbSNP
rs1274849476 945 dbSNP
rs1206904928 953 dbSNP
rs974860736 962 dbSNP
rs1032782637 965 dbSNP
rs1219319531 968 dbSNP
rs1369559060 976 dbSNP
rs943723215 977 dbSNP
rs542364927 982 dbSNP
rs368863451 983 dbSNP
rs1343743675 985 dbSNP
rs913427077 987 dbSNP
rs1040683262 988 dbSNP
rs755978360 989 dbSNP
rs550984447 990 dbSNP
rs1416242195 996 dbSNP
rs1260819010 1000 dbSNP
rs1042783534 1002 dbSNP
rs1473107159 1007 dbSNP
rs1254504363 1012 dbSNP
rs1481275434 1013 dbSNP
rs1200506584 1020 dbSNP
rs1479423059 1021 dbSNP
rs1250418198 1023 dbSNP
rs1377275770 1025 dbSNP
rs937359721 1026 dbSNP
rs1261155773 1042 dbSNP
rs181752258 1044 dbSNP
rs1329596980 1045 dbSNP
rs568547948 1056 dbSNP
rs1001007465 1058 dbSNP
rs920009857 1060 dbSNP
rs930072651 1071 dbSNP
rs1419578892 1073 dbSNP
rs535281030 1074 dbSNP
rs1296864001 1075 dbSNP
rs1404059590 1075 dbSNP
rs556768160 1077 dbSNP
rs1347826776 1085 dbSNP
rs775737358 1093 dbSNP
rs1405918242 1098 dbSNP
rs1414861024 1104 dbSNP
rs1157293827 1106 dbSNP
rs568798409 1114 dbSNP
rs539317426 1120 dbSNP
rs1330079310 1122 dbSNP
rs1182137521 1124 dbSNP
rs1462243001 1128 dbSNP
rs1014242319 1137 dbSNP
rs1025004907 1138 dbSNP
rs897157071 1139 dbSNP
rs1008783083 1145 dbSNP
rs1040319742 1146 dbSNP
rs994288703 1150 dbSNP
rs1027040223 1159 dbSNP
rs952528470 1160 dbSNP
rs1283788030 1162 dbSNP
rs1388636719 1165 dbSNP
rs1490797180 1169 dbSNP
rs985289306 1180 dbSNP
rs957126049 1181 dbSNP
rs1266951046 1187 dbSNP
rs557655186 1188 dbSNP
rs1018623468 1196 dbSNP
rs1431618843 1198 dbSNP
rs1165031744 1200 dbSNP
rs1446141767 1211 dbSNP
rs563510525 1217 dbSNP
rs977055060 1218 dbSNP
rs1364509110 1219 dbSNP
rs572460328 1227 dbSNP
rs945705118 1228 dbSNP
rs768787074 1232 dbSNP
rs1203365974 1251 dbSNP
rs981635499 1258 dbSNP
rs1265872122 1260 dbSNP
rs1224466445 1263 dbSNP
rs1357473913 1277 dbSNP
rs1314669870 1283 dbSNP
rs1367941417 1284 dbSNP
rs1425690508 1285 dbSNP
rs540232455 1289 dbSNP
rs1367505137 1295 dbSNP
rs1294023204 1299 dbSNP
rs1293261244 1300 dbSNP
rs1389591548 1301 dbSNP
rs1384766123 1308 dbSNP
rs1295593739 1309 dbSNP
rs7589796 1313 dbSNP
rs1363283050 1319 dbSNP
rs4666072 1330 dbSNP
rs1238779379 1331 dbSNP
rs925666345 1343 dbSNP
rs1374335478 1344 dbSNP
rs761738020 1352 dbSNP
rs1307015702 1358 dbSNP
rs573725428 1364 dbSNP
rs895287056 1365 dbSNP
rs542034555 1373 dbSNP
rs930066431 1383 dbSNP
rs1245288693 1385 dbSNP
rs1047184523 1386 dbSNP
rs949703210 1388 dbSNP
rs1341558922 1397 dbSNP
rs1487370373 1407 dbSNP
rs1197820054 1410 dbSNP
rs1332111418 1413 dbSNP
rs2279990 1426 dbSNP
rs1457379232 1437 dbSNP
rs1176781723 1441 dbSNP
rs368166363 1445 dbSNP
rs1403439094 1447 dbSNP
rs897167074 1448 dbSNP
rs1040288132 1450 dbSNP
rs776395832 1453 dbSNP
rs759420095 1456 dbSNP
rs1027092623 1459 dbSNP
rs1165586842 1461 dbSNP
rs1461072750 1464 dbSNP
rs1164659680 1466 dbSNP
rs1378089043 1466 dbSNP
rs888511190 1468 dbSNP
rs1178563836 1470 dbSNP
rs900409388 1471 dbSNP
rs184499178 1477 dbSNP
rs546488990 1478 dbSNP
rs564770709 1488 dbSNP
rs1183144433 1490 dbSNP
rs1018129141 1494 dbSNP
rs1299583177 1495 dbSNP
rs965582666 1500 dbSNP
rs1439715212 1501 dbSNP
rs77148777 1502 dbSNP
rs1195259703 1510 dbSNP
rs1445412999 1513 dbSNP
rs892828197 1519 dbSNP
rs1222265335 1524 dbSNP
rs1328643786 1529 dbSNP
rs1020123095 1531 dbSNP
rs1323266799 1541 dbSNP
rs967020009 1544 dbSNP
rs775493248 1546 dbSNP
rs1444821969 1553 dbSNP
rs1337121252 1556 dbSNP
rs1326472245 1560 dbSNP
rs1390295050 1570 dbSNP
rs1396586974 1572 dbSNP
rs1178499282 1576 dbSNP
rs1468222231 1583 dbSNP
rs1428530331 1594 dbSNP
rs780114265 1596 dbSNP
rs1159537998 1602 dbSNP
rs1471055069 1603 dbSNP
rs1362222298 1609 dbSNP
rs1009954516 1623 dbSNP
rs978372691 1632 dbSNP
rs1245113117 1634 dbSNP
rs1202315416 1642 dbSNP
rs1461208159 1644 dbSNP
rs1020008948 1648 dbSNP
rs547009818 1649 dbSNP
rs925717844 1653 dbSNP
rs752456290 1657 dbSNP
rs562022145 1660 dbSNP
rs991645221 1661 dbSNP
rs1382872726 1667 dbSNP
rs1258953225 1673 dbSNP
rs1449836768 1681 dbSNP
rs189987815 1684 dbSNP
rs1318911918 1694 dbSNP
rs949549712 1698 dbSNP
rs1046687007 1699 dbSNP
rs529424267 1705 dbSNP
rs1196855588 1707 dbSNP
rs747054048 1710 dbSNP
rs929975296 1712 dbSNP
rs550680485 1713 dbSNP
rs974763483 1715 dbSNP
rs1387318616 1722 dbSNP
rs768885340 1723 dbSNP
rs762079686 1725 dbSNP
rs1444108893 1734 dbSNP
rs1249165273 1735 dbSNP
rs888424727 1736 dbSNP
rs568686120 1737 dbSNP
rs762690573 1738 dbSNP
rs951461224 1741 dbSNP
rs982842905 1747 dbSNP
rs1210825306 1760 dbSNP
rs1359624223 1761 dbSNP
rs1316750469 1764 dbSNP
rs866501050 1771 dbSNP
rs1243069288 1776 dbSNP
rs368760725 1777 dbSNP
rs1343200399 1779 dbSNP
rs1040182992 1782 dbSNP
rs763775249 1784 dbSNP
rs1367630565 1788 dbSNP
rs975897517 1798 dbSNP
rs1424064330 1799 dbSNP
rs921799877 1800 dbSNP
rs181203381 1807 dbSNP
rs539253070 1808 dbSNP
rs967238013 1813 dbSNP
rs572834271 1816 dbSNP
rs1000056026 1820 dbSNP
rs1464737589 1822 dbSNP
rs1032718957 1824 dbSNP
rs551221719 1829 dbSNP
rs991262302 1831 dbSNP
rs916946705 1834 dbSNP
rs566800110 1836 dbSNP
rs370380022 1837 dbSNP
rs894641597 1838 dbSNP
rs1269545274 1839 dbSNP
rs1405305965 1841 dbSNP
rs533551476 1859 dbSNP
rs80003980 1860 dbSNP
rs756680148 1880 dbSNP
rs930237092 1899 dbSNP
rs1048673535 1908 dbSNP
rs1419363495 1911 dbSNP
rs1383735514 1916 dbSNP
rs909916610 1917 dbSNP
rs1267292893 1918 dbSNP
rs1196820360 1920 dbSNP
rs1490067216 1921 dbSNP
rs143179014 1933 dbSNP
rs1339571756 1934 dbSNP
rs148258107 1941 dbSNP
rs901229561 1942 dbSNP
rs1272166174 1943 dbSNP
rs965453468 1950 dbSNP
rs997985573 1951 dbSNP
rs1041561315 1954 dbSNP
rs975529293 1956 dbSNP
rs1404118846 1958 dbSNP
rs373788078 1967 dbSNP
rs921753197 1972 dbSNP
rs931811535 1977 dbSNP
rs556314614 1981 dbSNP
rs569232149 1982 dbSNP
rs1033308038 1986 dbSNP
rs945989417 1991 dbSNP
rs750871342 1994 dbSNP
rs1012975338 1997 dbSNP
rs546425739 2001 dbSNP
rs564758747 2002 dbSNP
rs971166796 2005 dbSNP
rs1178617949 2007 dbSNP
rs1477028956 2009 dbSNP
rs1479370488 2021 dbSNP
rs1237100391 2022 dbSNP
rs971790660 2029 dbSNP
rs1462548355 2031 dbSNP
rs918796280 2042 dbSNP
rs186143743 2043 dbSNP
rs984379414 2046 dbSNP
rs1222619323 2047 dbSNP
rs1430959367 2049 dbSNP
rs910084219 2057 dbSNP
rs1317346272 2060 dbSNP
rs942735062 2080 dbSNP
rs894618391 2083 dbSNP
rs996093666 2086 dbSNP
rs1315749895 2087 dbSNP
rs540252990 2088 dbSNP
rs1404489267 2096 dbSNP
rs1455326197 2097 dbSNP
rs922614621 2098 dbSNP
rs1336705656 2103 dbSNP
rs934100434 2108 dbSNP
rs1347385616 2109 dbSNP
rs1041776909 2110 dbSNP
rs903032387 2112 dbSNP
rs1416884266 2115 dbSNP
rs1359733730 2119 dbSNP
rs1379311669 2128 dbSNP
rs1019618721 2129 dbSNP
rs1445946905 2131 dbSNP
rs1397895350 2135 dbSNP
rs756555612 2141 dbSNP
rs865845040 2144 dbSNP
rs996895117 2176 dbSNP
rs1028844935 2178 dbSNP
rs1368495957 2181 dbSNP
rs1316031084 2195 dbSNP
rs1316487688 2195 dbSNP
rs958175940 2198 dbSNP
rs1218754393 2203 dbSNP
rs1380729514 2204 dbSNP
rs1299226916 2206 dbSNP
rs894356952 2207 dbSNP
rs1318792400 2212 dbSNP
rs1012824010 2213 dbSNP
rs1364718816 2216 dbSNP
rs1287420607 2221 dbSNP
rs1024416383 2231 dbSNP
rs562082337 2232 dbSNP
rs1487546749 2236 dbSNP
rs1225114668 2239 dbSNP
rs1382920688 2240 dbSNP
rs1248126595 2243 dbSNP
rs1428989430 2245 dbSNP
rs528535310 2252 dbSNP
rs1184515578 2256 dbSNP
rs780388934 2267 dbSNP
rs967259414 2268 dbSNP
rs977314366 2271 dbSNP
rs1357354881 2279 dbSNP
rs951527027 2287 dbSNP
rs984671925 2325 dbSNP
rs12614037 2336 dbSNP
rs1264882891 2350 dbSNP
rs529296609 2354 dbSNP
rs1440991094 2376 dbSNP
rs1381991137 2377 dbSNP
rs550616379 2377 dbSNP
rs1346581075 2378 dbSNP
rs1303370471 2380 dbSNP
rs562652039 2385 dbSNP
rs532951692 2387 dbSNP
rs922639824 2390 dbSNP
rs1304691501 2397 dbSNP
rs141693061 2402 dbSNP
rs1374676100 2416 dbSNP
rs73925326 2418 dbSNP
rs547050115 2419 dbSNP
rs1375705818 2422 dbSNP
rs1489902859 2425 dbSNP
rs1266983536 2426 dbSNP
rs935852381 2431 dbSNP
rs1049039159 2432 dbSNP
rs1250091508 2434 dbSNP
rs1218629430 2437 dbSNP
rs1324697243 2441 dbSNP
rs887310051 2447 dbSNP
rs1054726421 2448 dbSNP
rs1328955020 2455 dbSNP
rs1322500175 2456 dbSNP
rs761905643 2457 dbSNP
rs894292891 2458 dbSNP
rs948686915 2462 dbSNP
rs1429913945 2464 dbSNP
rs1178278585 2470 dbSNP
rs1248651317 2472 dbSNP
rs1479348138 2484 dbSNP
rs1045640959 2501 dbSNP
rs1182854860 2502 dbSNP
rs1347321192 2510 dbSNP
rs906873684 2514 dbSNP
rs993123428 2521 dbSNP
rs997268812 2522 dbSNP
rs367586664 2528 dbSNP
rs1265573613 2537 dbSNP
rs1462104585 2537 dbSNP
rs146215342 2542 dbSNP
rs568497506 2543 dbSNP
rs1244603753 2544 dbSNP
rs1273878344 2546 dbSNP
rs1011024758 2548 dbSNP
rs1021840988 2550 dbSNP
rs1220742259 2551 dbSNP
rs190517691 2557 dbSNP
rs1035681534 2558 dbSNP
rs960293163 2564 dbSNP
rs1005956243 2565 dbSNP
rs1401311339 2567 dbSNP
rs1468012797 2567 dbSNP
rs1159348924 2569 dbSNP
rs1164910685 2575 dbSNP
rs770256506 2577 dbSNP
rs1362281029 2578 dbSNP
rs1178054930 2579 dbSNP
rs150516041 2579 dbSNP
rs928566434 2585 dbSNP
rs1442194400 2587 dbSNP
rs1414313717 2591 dbSNP
rs1404547013 2592 dbSNP
rs959977546 2597 dbSNP
rs991545768 2602 dbSNP
rs915621659 2607 dbSNP
rs768877076 2613 dbSNP
rs36030057 2617 dbSNP
rs114502529 2623 dbSNP
rs1317076287 2626 dbSNP
rs1447619750 2632 dbSNP
rs976079208 2633 dbSNP
rs1029830886 2647 dbSNP
rs1374733248 2648 dbSNP
rs1455091338 2655 dbSNP
rs1263523143 2664 dbSNP
rs955393860 2669 dbSNP
rs1158323063 2670 dbSNP
rs35007336 2673 dbSNP
rs977364232 2676 dbSNP
rs908671340 2678 dbSNP
rs1387224660 2679 dbSNP
rs1356155958 2684 dbSNP
rs940191110 2684 dbSNP
rs376644432 2687 dbSNP
rs1243231973 2697 dbSNP
rs182950169 2699 dbSNP
rs779061446 2702 dbSNP
rs1319506681 2703 dbSNP
rs957711258 2704 dbSNP
rs1237089763 2705 dbSNP
rs997145852 2710 dbSNP
rs370219264 2711 dbSNP
rs748292817 2714 dbSNP
rs1021011352 2715 dbSNP
rs1472351776 2718 dbSNP
rs35550551 2718 dbSNP
rs1432607985 2719 dbSNP
rs1338196760 2720 dbSNP
rs902994763 2729 dbSNP
rs556251135 2730 dbSNP
rs773435189 2735 dbSNP
rs1161175748 2742 dbSNP
rs1035512343 2752 dbSNP
rs539821573 2755 dbSNP
rs142372605 2756 dbSNP
rs928968611 2761 dbSNP
rs1047457884 2762 dbSNP
rs776682878 2765 dbSNP
rs1398285703 2766 dbSNP
rs1200613652 2769 dbSNP
rs116541665 2770 dbSNP
rs1270632693 2777 dbSNP
rs1038748211 2780 dbSNP
rs145947594 2784 dbSNP
rs1273591959 2785 dbSNP
rs540896347 2789 dbSNP
rs1446318416 2792 dbSNP
rs769779453 2797 dbSNP
rs1347567314 2798 dbSNP
rs190617394 2798 dbSNP
rs1029883672 2801 dbSNP
rs775432176 2807 dbSNP
rs922797732 2809 dbSNP
rs1331448374 2812 dbSNP
rs999046350 2820 dbSNP
rs116122977 2828 dbSNP
rs957388690 2829 dbSNP
rs1481634850 2831 dbSNP
rs1426801676 2851 dbSNP
rs990644868 2854 dbSNP
rs1201616545 2855 dbSNP
rs893775072 2856 dbSNP
rs544241319 2864 dbSNP
rs1206012880 2875 dbSNP
rs1441733374 2880 dbSNP
rs915955614 2881 dbSNP
rs970312804 2887 dbSNP
rs1456354837 2888 dbSNP
rs1257372385 2891 dbSNP
rs981241538 2893 dbSNP
rs562639796 2894 dbSNP
rs929230503 2902 dbSNP
rs1299463992 2911 dbSNP
rs1218923881 2914 dbSNP
rs1249771337 2917 dbSNP
rs1374350019 2918 dbSNP
rs372812158 2921 dbSNP
rs908904497 2922 dbSNP
rs762780334 2926 dbSNP
rs1338012108 2932 dbSNP
rs941666482 2934 dbSNP
rs763869702 2936 dbSNP
rs1421676134 2938 dbSNP
rs1039213686 2955 dbSNP
rs900221762 2963 dbSNP
rs1357855632 2965 dbSNP
rs997663409 2974 dbSNP
rs1173189854 2978 dbSNP
rs1413486805 2984 dbSNP
rs1035479847 2986 dbSNP
rs1051230886 2987 dbSNP
rs1437334273 2992 dbSNP
rs1237464351 2997 dbSNP
rs1184209032 3000 dbSNP
rs1300555020 3002 dbSNP
rs891293252 3012 dbSNP
rs751223855 3014 dbSNP
rs544787462 3015 dbSNP
rs139454543 3023 dbSNP
rs1238024148 3025 dbSNP
rs1286632995 3025 dbSNP
rs952456205 3038 dbSNP
rs1316344944 3043 dbSNP
rs4665419 3044 dbSNP
rs1377638695 3045 dbSNP
rs1302593772 3050 dbSNP
rs1234824444 3053 dbSNP
rs1454654324 3054 dbSNP
rs1345395125 3063 dbSNP
rs1160129164 3066 dbSNP
rs1417317152 3072 dbSNP
rs1274876025 3073 dbSNP
rs766923483 3074 dbSNP
rs1011551144 3076 dbSNP
rs1163686266 3078 dbSNP
rs1015306559 3081 dbSNP
rs1288059837 3082 dbSNP
rs547385631 3096 dbSNP
rs1181016096 3098 dbSNP
rs1486098479 3109 dbSNP
rs1215534946 3117 dbSNP
rs1261337625 3121 dbSNP
rs1435076830 3123 dbSNP
rs149862614 3124 dbSNP
rs922724089 3125 dbSNP
rs932854148 3125 dbSNP
rs981505412 3141 dbSNP
rs531320932 3144 dbSNP
rs549847124 3145 dbSNP
rs915482564 3146 dbSNP
rs946981711 3148 dbSNP
rs950522343 3150 dbSNP
rs983370893 3153 dbSNP
rs1419486659 3154 dbSNP
rs902558187 3166 dbSNP
rs909108345 3167 dbSNP
rs939405390 3170 dbSNP
rs941705801 3171 dbSNP
rs1056476996 3172 dbSNP
rs895617986 3176 dbSNP
rs974464366 3188 dbSNP
rs181888258 3190 dbSNP
rs867286412 3202 dbSNP
rs921579207 3204 dbSNP
rs1388190077 3210 dbSNP
rs1488047702 3211 dbSNP
rs1323802538 3214 dbSNP
rs1211693153 3218 dbSNP
rs1487570115 3228 dbSNP
rs1330060622 3234 dbSNP
rs1265368533 3239 dbSNP
rs1231363209 3245 dbSNP
rs1228869309 3246 dbSNP
rs1012766795 3250 dbSNP
rs756580326 3252 dbSNP
rs1044651170 3253 dbSNP
rs1311374366 3258 dbSNP
rs186443912 3264 dbSNP
rs1387979953 3265 dbSNP
rs1051454451 3268 dbSNP
rs553608893 3273 dbSNP
rs1005504469 3275 dbSNP
rs1292859845 3276 dbSNP
rs1239181295 3277 dbSNP
rs1015232988 3279 dbSNP
rs1168211286 3280 dbSNP
rs567010929 3284 dbSNP
rs1489323719 3289 dbSNP
rs190845909 3291 dbSNP
rs182993322 3292 dbSNP
rs1449956873 3293 dbSNP
rs1029427506 3294 dbSNP
rs953957074 3294 dbSNP
rs1459447958 3297 dbSNP
rs985627690 3307 dbSNP
rs1053796045 3316 dbSNP
rs780479024 3323 dbSNP
rs1324769703 3338 dbSNP
rs1275072987 3349 dbSNP
rs1012227670 3355 dbSNP
rs868179447 3361 dbSNP
rs978321862 3364 dbSNP
rs766924669 3392 dbSNP
rs574042867 3421 dbSNP
rs1458721220 3425 dbSNP
rs905855711 3430 dbSNP
rs1329274884 3432 dbSNP
rs939376004 3435 dbSNP
rs1002991957 3440 dbSNP
rs188283675 3448 dbSNP
rs1464670598 3449 dbSNP
rs1377311130 3451 dbSNP
rs1438113774 3452 dbSNP
rs1441681205 3454 dbSNP
rs1236856065 3456 dbSNP
rs1178639313 3461 dbSNP
rs1462037921 3466 dbSNP
rs1035742849 3468 dbSNP
rs916658924 3469 dbSNP
rs950549645 3478 dbSNP
rs1255101172 3482 dbSNP
rs1240203459 3486 dbSNP
rs983254241 3495 dbSNP
rs1306969779 3496 dbSNP
rs755299386 3499 dbSNP
rs1340996286 3500 dbSNP
rs1016499106 3514 dbSNP
rs1335890764 3517 dbSNP
rs948161336 3517 dbSNP
rs1044227346 3521 dbSNP
rs963350790 3525 dbSNP
rs975064966 3526 dbSNP
rs556174804 3537 dbSNP
rs191499126 3538 dbSNP
rs1158138706 3543 dbSNP
rs932956080 3549 dbSNP
rs1239755365 3551 dbSNP
rs182838926 3553 dbSNP
rs1442246022 3554 dbSNP
rs1332911537 3562 dbSNP
rs1216959614 3568 dbSNP
rs1355422591 3569 dbSNP
rs923666833 3580 dbSNP
rs1238827915 3581 dbSNP
rs1356899407 3590 dbSNP
rs1285929332 3616 dbSNP
rs1242304708 3619 dbSNP
rs934840466 3624 dbSNP
rs1339728972 3635 dbSNP
rs1036967009 3638 dbSNP
rs1402018932 3648 dbSNP
rs144838424 3659 dbSNP
rs377058729 3670 dbSNP
rs1162044588 3671 dbSNP
rs1472665987 3676 dbSNP
rs574826172 3677 dbSNP
rs187910681 3679 dbSNP
rs1045035408 3681 dbSNP
rs1196301955 3686 dbSNP
rs527437385 3688 dbSNP
rs1002851277 3689 dbSNP
rs1215227922 3690 dbSNP
rs1451719970 3691 dbSNP
rs1424759190 3695 dbSNP
rs1187232348 3696 dbSNP
rs1208055316 3703 dbSNP
rs1355577179 3709 dbSNP
rs1367552493 3709 dbSNP
rs1459590128 3712 dbSNP
rs1022428839 3713 dbSNP
rs1277857824 3729 dbSNP
rs1172331608 3731 dbSNP
rs1351746363 3740 dbSNP
rs1035789878 3747 dbSNP
rs1401700140 3756 dbSNP
rs1173207830 3757 dbSNP
rs529404997 3760 dbSNP
rs7586840 3770 dbSNP
rs1192575874 3773 dbSNP
rs1478064637 3778 dbSNP
rs1016139009 3782 dbSNP
rs1381171401 3785 dbSNP
rs924210553 3788 dbSNP
rs963537900 3789 dbSNP
rs996118949 3797 dbSNP
rs1396425920 3801 dbSNP
rs960976154 3805 dbSNP
rs879417886 3807 dbSNP
rs1257647157 3808 dbSNP
rs1219974413 3815 dbSNP
rs954394108 3827 dbSNP
rs987066463 3829 dbSNP
rs1353310859 3834 dbSNP
rs1220739244 3837 dbSNP
rs916610160 3838 dbSNP
rs1464392989 3851 dbSNP
rs191250777 3853 dbSNP
rs531664301 3855 dbSNP
rs183775029 3863 dbSNP
rs909691558 3872 dbSNP
rs1453320609 3874 dbSNP
rs148560952 3875 dbSNP
rs532151213 3878 dbSNP
rs1180493083 3879 dbSNP
rs914779312 3886 dbSNP
rs941185446 3889 dbSNP
rs748299946 3901 dbSNP
rs1483836504 3902 dbSNP
rs1036895064 3907 dbSNP
rs1200361701 3907 dbSNP
rs558541310 3908 dbSNP
rs1044654988 3912 dbSNP
rs1276829304 3928 dbSNP
rs1218684986 3938 dbSNP
rs1312085335 3939 dbSNP
rs1354584447 3939 dbSNP
rs1445143673 3947 dbSNP
rs1303754015 3948 dbSNP
rs1376820836 3948 dbSNP
rs897055334 3949 dbSNP
rs550867231 3952 dbSNP
rs927501280 3953 dbSNP
rs1479006109 3955 dbSNP
rs1380314349 3963 dbSNP
rs1433557852 3963 dbSNP
rs938902456 3967 dbSNP
rs1437702094 3975 dbSNP
rs1423823434 3977 dbSNP
rs1057178427 3979 dbSNP
rs1477212766 3982 dbSNP
rs886438059 3990 dbSNP
rs1484132859 3993 dbSNP
rs1177679508 3994 dbSNP
rs57155297 3997 dbSNP
rs889457778 3997 dbSNP
rs1038158343 4004 dbSNP
rs1238102440 4006 dbSNP
rs899002611 4007 dbSNP
rs565678172 4008 dbSNP
rs1314128304 4010 dbSNP
rs1028877923 4011 dbSNP
rs1022481758 4012 dbSNP
rs1413716103 4014 dbSNP
rs184093163 4016 dbSNP
rs756367097 4016 dbSNP
rs766904551 4016 dbSNP
rs148544997 4017 dbSNP
rs1491042292 4017 dbSNP
rs201208245 4017 dbSNP
rs3838585 4017 dbSNP
rs753912738 4017 dbSNP
rs869196958 4017 dbSNP
rs187697603 4018 dbSNP
rs777568624 4018 dbSNP
rs1411292885 4019 dbSNP
rs1491071157 4019 dbSNP
rs5830072 4032 dbSNP
rs1279079883 4033 dbSNP
rs1265644932 4034 dbSNP
rs1339253416 4034 dbSNP
rs1340069643 4035 dbSNP
rs1212903785 4036 dbSNP
rs192372316 4037 dbSNP
rs1303560669 4040 dbSNP
rs1312813802 4041 dbSNP
rs1233241380 4042 dbSNP
rs1278799288 4043 dbSNP
rs1266541985 4044 dbSNP
rs1489484301 4045 dbSNP
rs1224505294 4050 dbSNP
rs1217721394 4055 dbSNP
rs1263497003 4056 dbSNP
rs1485315368 4057 dbSNP
rs1184386780 4061 dbSNP
rs1219655190 4063 dbSNP
rs1340718225 4065 dbSNP
rs1279739589 4069 dbSNP
rs569114377 4076 dbSNP
rs1433264586 4083 dbSNP
rs1383685947 4087 dbSNP
rs999637750 4096 dbSNP
rs1175285537 4097 dbSNP
rs1008749286 4102 dbSNP
rs1163884482 4103 dbSNP
rs1478054473 4106 dbSNP
rs1426016249 4107 dbSNP
rs1031154242 4113 dbSNP
rs1427983110 4135 dbSNP
rs1268064258 4138 dbSNP
rs1193023411 4142 dbSNP
rs772255529 4143 dbSNP
rs1199628192 4145 dbSNP
rs534402014 4148 dbSNP
rs537668262 4149 dbSNP
rs914936129 4156 dbSNP
rs2175093 4159 dbSNP
rs968927868 4163 dbSNP
rs1359638045 4168 dbSNP
rs980707131 4171 dbSNP
rs1325497928 4172 dbSNP
rs1428933066 4173 dbSNP
rs1388037400 4175 dbSNP
rs1365383146 4176 dbSNP
rs1325186057 4198 dbSNP
rs1465943430 4199 dbSNP
rs145512070 4211 dbSNP
rs747044266 4226 dbSNP
rs3177065 4240 dbSNP
rs1378447320 4253 dbSNP
rs1252912721 4256 dbSNP
rs1431551477 4256 dbSNP
rs769868105 4274 dbSNP
rs1179877809 4275 dbSNP
rs1301887098 4284 dbSNP
rs984862128 4284 dbSNP
rs1236662629 4310 dbSNP
rs1356419065 4313 dbSNP
rs1195621565 4318 dbSNP
rs1338292629 4323 dbSNP
rs538113600 4326 dbSNP
rs4426489 4327 dbSNP
rs577568858 4328 dbSNP
rs899214232 4334 dbSNP
rs972557131 4335 dbSNP
rs745735303 4339 dbSNP
rs1328982162 4341 dbSNP
rs933889851 4345 dbSNP
rs1403143068 4347 dbSNP
rs11677589 4359 dbSNP
rs1174598116 4362 dbSNP
rs996259985 4363 dbSNP
rs1394491637 4364 dbSNP
rs1159329117 4366 dbSNP
rs538664567 4384 dbSNP
rs1442048847 4390 dbSNP
rs1213297340 4398 dbSNP
rs1051456855 4400 dbSNP
rs1181513045 4401 dbSNP
rs1443398450 4406 dbSNP
rs749133409 4410 dbSNP
rs1248034145 4411 dbSNP
rs554227489 4412 dbSNP
rs1192413646 4416 dbSNP
rs1008801899 4427 dbSNP
rs748429139 4433 dbSNP
rs558072736 4434 dbSNP
rs1030841534 4445 dbSNP
rs577080070 4446 dbSNP
rs1398724197 4448 dbSNP
rs1340900623 4455 dbSNP
rs903597832 4457 dbSNP
rs1413089043 4466 dbSNP
rs1010965745 4468 dbSNP
rs1021948782 4471 dbSNP
rs1167193613 4473 dbSNP
rs969568730 4474 dbSNP
rs1421652949 4480 dbSNP
rs376971531 4482 dbSNP
rs1158565725 4488 dbSNP
rs952583594 4489 dbSNP
rs896659437 4493 dbSNP
rs983915066 4495 dbSNP
rs1034551716 4499 dbSNP
rs1253047799 4501 dbSNP
rs1013812152 4502 dbSNP
rs1204415473 4502 dbSNP
rs1356967331 4502 dbSNP
rs1437438620 4502 dbSNP
rs184285024 4502 dbSNP
rs541655519 4502 dbSNP
rs878869272 4502 dbSNP
rs1024318073 4503 dbSNP
rs1448224446 4504 dbSNP
rs960162477 4505 dbSNP
rs78680413 4506 dbSNP
rs1401922369 4507 dbSNP
rs1309169387 4508 dbSNP
rs1317740834 4522 dbSNP
rs1371706650 4523 dbSNP
rs80354929 4523 dbSNP
rs1191348117 4524 dbSNP
rs1291615348 4525 dbSNP
rs75693411 4526 dbSNP
rs752461537 4531 dbSNP
rs534505790 4549 dbSNP
rs1461285426 4562 dbSNP
rs1416710041 4567 dbSNP
rs561098916 4568 dbSNP
rs1478604150 4581 dbSNP
rs147698077 4582 dbSNP
rs570111647 4590 dbSNP
rs973838557 4591 dbSNP
rs1452063710 4595 dbSNP
rs920585960 4600 dbSNP
rs972151960 4601 dbSNP
rs918385513 4602 dbSNP
rs932096394 4603 dbSNP
rs552779424 4604 dbSNP
rs1232176545 4619 dbSNP
rs933837089 4622 dbSNP
rs1360141781 4647 dbSNP
rs1269631888 4656 dbSNP
rs1437340319 4656 dbSNP
rs1333301706 4661 dbSNP
rs189115602 4671 dbSNP
rs986706891 4673 dbSNP
rs182205655 4676 dbSNP
rs1440612614 4683 dbSNP
rs1468415821 4690 dbSNP
rs1183340028 4691 dbSNP
rs1414829091 4700 dbSNP
rs890294196 4702 dbSNP
rs760382006 4703 dbSNP
rs1166787223 4706 dbSNP
rs1163021013 4726 dbSNP
rs879193163 4739 dbSNP
rs774109537 4749 dbSNP
rs1248383386 4750 dbSNP
rs1191736747 4755 dbSNP
rs1052321012 4757 dbSNP
rs892405927 4762 dbSNP
rs911118484 4763 dbSNP
rs1010805920 4764 dbSNP
rs1022419553 4766 dbSNP
rs1200343167 4779 dbSNP
rs574192867 4781 dbSNP
rs114835682 4785 dbSNP
rs755710585 4786 dbSNP
rs1043372319 4787 dbSNP
rs1378326981 4794 dbSNP
rs541568268 4798 dbSNP
rs1334463874 4800 dbSNP
rs1034730292 4801 dbSNP
rs924985863 4802 dbSNP
rs935040078 4809 dbSNP
rs960211411 4811 dbSNP
rs534347917 4830 dbSNP
rs1285203821 4840 dbSNP
rs992964994 4841 dbSNP
rs1052152706 4842 dbSNP
rs532126479 4852 dbSNP
rs1380868668 4857 dbSNP
rs896628117 4861 dbSNP
rs1479573667 4865 dbSNP
rs1232504383 4868 dbSNP
rs1211016568 4869 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ggggggaggggCCCUGgg 5'
                     |||||  
Target 5' uagagaauuugGGGAC-- 3'
 		1 - 16
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_005253 | 3UTR | GCACCUCCCUCCCCAGCUCCGGAGGGGGUCCUCCUCGCUCCUCCUUCCCAGGGACCAGCACCUUCAAGCGCUCCAGGGCCGUGAGGGCAAGAGGGGGACCUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000379619.1 | 3UTR | UAGAGAAUUUGGGGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
29 hsa-miR-4281 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT218864 CDKN1A cyclin dependent kinase inhibitor 1A 2 4
MIRT248841 SESN2 sestrin 2 2 2
MIRT452803 PACS2 phosphofurin acidic cluster sorting protein 2 2 2
MIRT462825 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT467812 SLC29A2 solute carrier family 29 member 2 2 2
MIRT477707 EFHD2 EF-hand domain family member D2 2 2
MIRT490047 PRRT2 proline rich transmembrane protein 2 2 2
MIRT491813 ZBTB7B zinc finger and BTB domain containing 7B 2 2
MIRT528905 THBS2 thrombospondin 2 2 2
MIRT534124 SNX33 sorting nexin 33 2 2
MIRT550881 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT551263 PSMG1 proteasome assembly chaperone 1 2 2
MIRT551984 UGT2B10 UDP glucuronosyltransferase family 2 member B10 2 2
MIRT608916 NCDN neurochondrin 2 6
MIRT637226 TMEM59 transmembrane protein 59 2 2
MIRT644445 ALDOC aldolase, fructose-bisphosphate C 2 2
MIRT657162 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT658754 ELAVL3 ELAV like RNA binding protein 3 2 2
MIRT668304 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT687548 MLEC malectin 2 2
MIRT690860 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT697063 PSMC4 proteasome 26S subunit, ATPase 4 2 2
MIRT700860 PER2 period circadian clock 2 2 2
MIRT705073 C4orf29 abhydrolase domain containing 18 2 2
MIRT713930 PIGR polymeric immunoglobulin receptor 2 2
MIRT715904 MFRP membrane frizzled-related protein 2 2
MIRT716060 SFTPB surfactant protein B 2 2
MIRT716729 APOL6 apolipoprotein L6 2 2
MIRT723382 NFAM1 NFAT activating protein with ITAM motif 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4281 Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4281 Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4281 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4281 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (PLX4032, LM16)
hsa-miR-4281 Cisplatin 5460033 NSC119875 approved resistant High Pancreatic Cancer cell line (BxPC-3)
hsa-miR-4281 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375)
hsa-miR-4281 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4281 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H460)
hsa-mir-4281 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4281 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-mir-4281 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-mir-4281 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-mir-4281 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-4281 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4281 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4281 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4281 Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-4281 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-4281 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-4281 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4281 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4281 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4281 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4281 Cisplatin 5460033 NSC119875 approved sensitive cell line (TOV-112D)
hsa-miR-4281 Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)

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