pre-miRNA Information
pre-miRNA hsa-mir-6787   
Genomic Coordinates chr17: 82236668 - 82236728
Description Homo sapiens miR-6787 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6787-5p
Sequence 6| UGGCGGGGGUAGAGCUGGCUGC |27
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778888046 4 dbSNP
rs772018061 5 dbSNP
rs760886644 6 dbSNP
rs776925052 7 dbSNP
rs760060985 8 dbSNP
rs1432528063 9 dbSNP
rs778772390 10 dbSNP
rs924024166 11 dbSNP
rs201523090 13 dbSNP
rs1451075810 17 dbSNP
rs1378844609 18 dbSNP
Putative Targets

Gene Information
Gene Symbol KIAA1551   
Synonyms C12orf35, GET, UTA2-1
Description KIAA1551
Transcript NM_018169   
Expression
Putative miRNA Targets on KIAA1551
3'UTR of KIAA1551
(miRNA target sites are highlighted)
>KIAA1551|NM_018169|3'UTR
   1 TTACAAGATGTGGTTTTGTAATTGCCACTGGGAAATTTCTTTCCTTTTCTGTTCAAAATATTTCGCTGAAACTAATGAGA
  81 AATGCCATGATAAAGATTTCTCAGAGTTTGGTTCCCACTTTCATTGTATTTCATTGAAAGTGCTTAATTAAAATGGCTTG
 161 AGAACTTTGGGTAGCCATGTGTAAGAAATGGATGGTATTCACCGGGGAAACAAGGTATTTGAATTTCTACTTTATTGAAC
 241 CAGATTTACCATTATTTTAAAAGGAATGCTTATACAAATCAATTTGAAATTCTACCCATCTTGAGGGAGGACCGTTCCTC
 321 AGTTAAGGACTTGTTTATTTAAATGGGACTGTAAATATGTTTTGGTTTCTAAGCTATATTAGCAAAATTTATTTTTCAAA
 401 AATGCCCACTGTGATGTGAATGTCAAAATATATTCTTAAGTGTTTTATAACTAATTGTAAACTTTTTTTCAGAAGTCTTA
 481 TTTTATACTTGTGAAACTGAACACAATTTTGGGACAACGTTTAAACATTACTTTTCATACTTGAAATAAACATTTATTTT
 561 TTAAAAAACTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgucggUCGAGAUGGGGGCGGu 5'
                ||:|: :::||| |: 
Target 5' tctcagAGTTTGGTTCCCACTt 3'
99 - 120 92.00 -12.50
2
miRNA  3' cgucGGUCGAG----AUGGGGGCGGu 5'
              :| |:||    || :::|||: 
Target 5' ctttTCTGTTCAAAATA-TTTCGCTg 3'
44 - 68 83.00 -8.50
3
miRNA  3' cgucggUCGAGAUGGGGGCGGu 5'
                | :||||  ||| :| 
Target 5' atttgaAATTCTA--CCCATCt 3'
282 - 301 79.00 -11.43
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30511422 8 COSMIC
COSN30511420 9 COSMIC
COSN19462192 31 COSMIC
COSN30453398 44 COSMIC
COSN20077742 52 COSMIC
COSN30155073 55 COSMIC
COSN31581171 63 COSMIC
COSN30446987 65 COSMIC
COSN30148604 88 COSMIC
COSN30152275 96 COSMIC
COSN31525488 99 COSMIC
COSN31586002 101 COSMIC
COSN8586000 124 COSMIC
COSN28637255 170 COSMIC
COSN22536184 189 COSMIC
COSN31566841 301 COSMIC
COSN29869481 448 COSMIC
COSN31486611 544 COSMIC
COSN30372258 561 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1244471639 1 dbSNP
rs140283743 2 dbSNP
rs761558428 2 dbSNP
rs769633524 3 dbSNP
rs771759935 4 dbSNP
rs1057085580 5 dbSNP
rs915794016 6 dbSNP
rs369511087 17 dbSNP
rs1388735950 19 dbSNP
rs772819540 21 dbSNP
rs1214383707 33 dbSNP
rs760279522 36 dbSNP
rs1201953055 39 dbSNP
rs771305776 40 dbSNP
rs1262788038 42 dbSNP
rs1184206376 44 dbSNP
rs776800275 47 dbSNP
rs1465553653 49 dbSNP
rs1469897400 52 dbSNP
rs184472712 57 dbSNP
rs11539999 60 dbSNP
rs948440131 61 dbSNP
rs1410938562 62 dbSNP
rs1176610361 65 dbSNP
rs574353842 66 dbSNP
rs1038271779 76 dbSNP
rs552563704 77 dbSNP
rs1464927060 86 dbSNP
rs1249355630 89 dbSNP
rs1207323884 90 dbSNP
rs1464893413 92 dbSNP
rs117220556 93 dbSNP
rs190222249 94 dbSNP
rs146822999 104 dbSNP
rs750910356 113 dbSNP
rs114323263 116 dbSNP
rs562183763 122 dbSNP
rs943946302 123 dbSNP
rs1318690280 125 dbSNP
rs1039603617 136 dbSNP
rs529792454 149 dbSNP
rs1459665882 154 dbSNP
rs549929126 160 dbSNP
rs899746214 169 dbSNP
rs541410860 172 dbSNP
rs998743266 176 dbSNP
rs563258674 178 dbSNP
rs1467349557 185 dbSNP
rs79108287 188 dbSNP
rs1021865622 189 dbSNP
rs1174840475 191 dbSNP
rs1449715882 194 dbSNP
rs1400976670 197 dbSNP
rs375774394 204 dbSNP
rs998987219 205 dbSNP
rs553660884 225 dbSNP
rs1202736670 226 dbSNP
rs1482442556 230 dbSNP
rs139268880 234 dbSNP
rs1206119686 244 dbSNP
rs758923720 245 dbSNP
rs1344668189 247 dbSNP
rs1295458289 255 dbSNP
rs959665687 256 dbSNP
rs991703439 260 dbSNP
rs1022680670 264 dbSNP
rs1228202883 267 dbSNP
rs1311428484 268 dbSNP
rs1313300369 270 dbSNP
rs747326881 274 dbSNP
rs77653313 281 dbSNP
rs973624841 287 dbSNP
rs1312115495 297 dbSNP
rs966794374 300 dbSNP
rs978208496 301 dbSNP
rs1283427136 304 dbSNP
rs1487879924 307 dbSNP
rs769119076 310 dbSNP
rs1190149977 313 dbSNP
rs542069976 314 dbSNP
rs181364628 315 dbSNP
rs993055421 334 dbSNP
rs752285759 345 dbSNP
rs911901155 348 dbSNP
rs1204749541 350 dbSNP
rs1431478138 351 dbSNP
rs943391649 359 dbSNP
rs948620564 360 dbSNP
rs1039048411 375 dbSNP
rs563660359 377 dbSNP
rs899777644 389 dbSNP
rs1338667485 390 dbSNP
rs947274834 398 dbSNP
rs1042913432 410 dbSNP
rs902987734 416 dbSNP
rs1295 419 dbSNP
rs1446457655 421 dbSNP
rs1157147502 431 dbSNP
rs746970857 433 dbSNP
rs1164560859 436 dbSNP
rs1035362259 437 dbSNP
rs895566343 447 dbSNP
rs1417838276 454 dbSNP
rs1012568442 457 dbSNP
rs1181663674 463 dbSNP
rs1250076895 463 dbSNP
rs1473754001 463 dbSNP
rs900918024 466 dbSNP
rs1269557365 474 dbSNP
rs1208185765 479 dbSNP
rs934189358 486 dbSNP
rs1050327668 490 dbSNP
rs1228932359 492 dbSNP
rs1420738503 498 dbSNP
rs1330875791 499 dbSNP
rs1023039036 506 dbSNP
rs1300412835 507 dbSNP
rs890048016 514 dbSNP
rs1324932062 515 dbSNP
rs1384519167 516 dbSNP
rs780321126 517 dbSNP
rs537135102 519 dbSNP
rs902552656 520 dbSNP
rs1410199616 527 dbSNP
rs564923172 528 dbSNP
rs1478464748 529 dbSNP
rs777586179 539 dbSNP
rs1379536927 540 dbSNP
rs1197058812 557 dbSNP
rs1451038233 563 dbSNP
rs1035131023 564 dbSNP
rs1026492865 569 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084047. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep4 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgUCGGUCGAGAUG---G-GGGCGGu 5'
            |||::|  :|||   | |||||| 
Target 5' guAGCUGGGAUUACAGGCGCCCGCCa 3'
1 - 26
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084047
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep4
Location of target site ENST00000312561.4 | 3UTR | GUAGCUGGGAUUACAGGCGCCCGCCACCACGCCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
90 hsa-miR-6787-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT449091 XPO6 exportin 6 2 2
MIRT449991 PSMG1 proteasome assembly chaperone 1 2 2
MIRT454608 MYADM myeloid associated differentiation marker 2 2
MIRT456116 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT457064 TOR4A torsin family 4 member A 2 2
MIRT461023 SDF4 stromal cell derived factor 4 2 2
MIRT467197 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT471711 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472566 NACC1 nucleus accumbens associated 1 2 2
MIRT476079 GRB2 growth factor receptor bound protein 2 2 2
MIRT480150 CALR calreticulin 2 2
MIRT483027 KHSRP KH-type splicing regulatory protein 2 4
MIRT483498 STMN3 stathmin 3 2 4
MIRT483728 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT484550 BARHL1 BarH like homeobox 1 2 6
MIRT484684 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT486059 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT486116 INO80E INO80 complex subunit E 2 2
MIRT486313 SIPA1 signal-induced proliferation-associated 1 2 2
MIRT486525 CLCN7 chloride voltage-gated channel 7 2 2
MIRT486857 DPF1 double PHD fingers 1 2 2
MIRT487352 PHF15 jade family PHD finger 2 1 1
MIRT487582 FAM83H family with sequence similarity 83 member H 2 4
MIRT487792 GPR20 G protein-coupled receptor 20 2 4
MIRT488104 POU3F1 POU class 3 homeobox 1 2 2
MIRT488786 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT489361 SYNGR1 synaptogyrin 1 2 4
MIRT489387 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT489680 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT489731 GNAI2 G protein subunit alpha i2 2 4
MIRT489750 TACC3 transforming acidic coiled-coil containing protein 3 2 2
MIRT490029 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT490379 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT490580 SLC47A1 solute carrier family 47 member 1 2 2
MIRT490753 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491187 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491301 VGF VGF nerve growth factor inducible 2 2
MIRT491462 HOXB8 homeobox B8 2 2
MIRT491702 PDZD4 PDZ domain containing 4 2 2
MIRT491724 RTN4R reticulon 4 receptor 2 2
MIRT491737 SEMA3F semaphorin 3F 2 2
MIRT491984 UNK unkempt family zinc finger 2 2
MIRT492844 NRGN neurogranin 2 2
MIRT492936 NEUROD2 neuronal differentiation 2 2 4
MIRT493713 H2AFX H2A histone family member X 2 2
MIRT494623 ASB6 ankyrin repeat and SOCS box containing 6 2 4
MIRT494703 ARHGAP31 Rho GTPase activating protein 31 2 2
MIRT495602 NKX2-5 NK2 homeobox 5 2 2
MIRT495750 PDE4C phosphodiesterase 4C 2 4
MIRT500367 ZNF385A zinc finger protein 385A 2 2
MIRT501161 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501702 PCGF3 polycomb group ring finger 3 2 6
MIRT504922 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT517945 TRIM59 tripartite motif containing 59 2 2
MIRT524212 DDI2 DNA damage inducible 1 homolog 2 2 6
MIRT531186 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT531972 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT558055 EVI5L ecotropic viral integration site 5 like 2 2
MIRT560482 LACE1 AFG1 like ATPase 2 2
MIRT563217 FXN frataxin 2 2
MIRT569095 FSCN1 fascin actin-bundling protein 1 2 2
MIRT569522 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 2
MIRT569531 CTTN cortactin 2 2
MIRT569848 RGS5 regulator of G protein signaling 5 2 2
MIRT570738 ANKRD52 ankyrin repeat domain 52 2 2
MIRT574140 MARVELD1 MARVEL domain containing 1 2 2
MIRT615994 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT628493 ZNF556 zinc finger protein 556 2 2
MIRT633451 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT649054 SLC1A2 solute carrier family 1 member 2 2 2
MIRT649340 HEXA hexosaminidase subunit alpha 2 2
MIRT670226 PTCHD1 patched domain containing 1 2 2
MIRT670666 KIAA1551 KIAA1551 2 2
MIRT671452 CDH7 cadherin 7 2 2
MIRT671729 ZNF451 zinc finger protein 451 2 2
MIRT690285 ZNF154 zinc finger protein 154 2 2
MIRT700575 PRSS22 protease, serine 22 2 2
MIRT701411 NKRF NFKB repressing factor 2 2
MIRT711877 VASP vasodilator stimulated phosphoprotein 2 2
MIRT712082 UNC13A unc-13 homolog A 2 2
MIRT712523 CYTH2 cytohesin 2 2 2
MIRT712751 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT714681 PRX periaxin 2 2
MIRT714718 VPS8 VPS8, CORVET complex subunit 2 2
MIRT717508 HRNR hornerin 2 2
MIRT717650 THBS2 thrombospondin 2 2 2
MIRT719592 PIAS4 protein inhibitor of activated STAT 4 2 2
MIRT720521 PTGR2 prostaglandin reductase 2 2 2
MIRT721295 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT724922 VPS18 VPS18, CORVET/HOPS core subunit 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6787 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6787-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-6787-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6787-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-6787-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6787-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6787-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-6787-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

Error report submission