pre-miRNA Information
pre-miRNA hsa-mir-4697   
Genomic Coordinates chr11: 133898504 - 133898581
Description Homo sapiens miR-4697 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4697-5p
Sequence 10| AGGGGGCGCAGUCACUGACGUG |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs549326907 2 dbSNP
rs897782230 7 dbSNP
rs748950280 8 dbSNP
rs978998780 15 dbSNP
rs968922289 19 dbSNP
rs3802919 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PCDHB2   
Synonyms PCDH-BETA2
Description protocadherin beta 2
Transcript NM_018936   
Expression
Putative miRNA Targets on PCDHB2
3'UTR of PCDHB2
(miRNA target sites are highlighted)
>PCDHB2|NM_018936|3'UTR
   1 GTGTTAATAAGGATCTACTGAGGCTAGTCTCGTTTAATTTGTGGAAAGTCCTTTTTTACTGCTTTGCCCATTGGAGGTGT
  81 CTCCTTTTATTAGAAAGTAACCATCTTATTCCAATTCTATGCATGTTACTGGTATTTATAAATGTATGAGTTTTTTTGCG
 161 GTATAATAAATGTAAATTTTCTTTGTATTCTAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gugcaGUCACUGACGCGGGGGa 5'
               || ||:  |:|:|:|| 
Target 5' ttgccCATTGGAGGTGTCTCCt 3'
64 - 85 109.00 -17.70
2
miRNA  3' gugcagucacugacgCGGGGGa 5'
                         |:||:: 
Target 5' tttaatttgtggaaaGTCCTTt 3'
33 - 54 72.00 -10.50
3
miRNA  3' gugcAGUCACUGACGCGgggga 5'
              | |||  :| :||     
Target 5' tgtaTGAGTTTTTTTGCggtat 3'
143 - 164 58.00 -7.02
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30450212 13 COSMIC
COSN8892349 22 COSMIC
COSN30139479 33 COSMIC
COSN30131506 58 COSMIC
COSN31614436 62 COSMIC
COSN26988135 68 COSMIC
COSN30148271 77 COSMIC
COSN31549501 78 COSMIC
COSN31525575 94 COSMIC
COSN20061932 98 COSMIC
COSN30523840 113 COSMIC
COSN31526164 118 COSMIC
COSN20052865 124 COSMIC
COSN31612839 133 COSMIC
COSN31497360 144 COSMIC
COSN31491273 149 COSMIC
COSN30185686 160 COSMIC
COSN30496798 160 COSMIC
COSN30149297 165 COSMIC
COSN20053517 169 COSMIC
COSN14143790 182 COSMIC
COSN31578915 194 COSMIC
COSN9927189 211 COSMIC
COSN5590621 262 COSMIC
COSN7877627 793 COSMIC
COSN27108231 1040 COSMIC
COSN5590622 1062 COSMIC
COSN19002374 1271 COSMIC
COSN5590623 1390 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs565166436 2 dbSNP
rs1243977858 3 dbSNP
rs115333775 12 dbSNP
rs781920312 16 dbSNP
rs782080935 18 dbSNP
rs1390949644 20 dbSNP
rs781967566 23 dbSNP
rs458800 24 dbSNP
rs782768270 25 dbSNP
rs1295179086 27 dbSNP
rs373189637 32 dbSNP
rs547378848 33 dbSNP
rs1441154075 34 dbSNP
rs149106573 35 dbSNP
rs781801699 36 dbSNP
rs465596 40 dbSNP
rs782429441 48 dbSNP
rs368531693 53 dbSNP
rs1268877939 61 dbSNP
rs1212102796 68 dbSNP
rs1490660006 69 dbSNP
rs368960842 88 dbSNP
rs1291407131 92 dbSNP
rs1004200093 107 dbSNP
rs1037469494 113 dbSNP
rs1220799801 118 dbSNP
rs898552962 120 dbSNP
rs3776103 124 dbSNP
rs1238646188 126 dbSNP
rs1334010205 128 dbSNP
rs1303522854 129 dbSNP
rs549876537 134 dbSNP
rs3776102 135 dbSNP
rs1003028251 140 dbSNP
rs1035900000 149 dbSNP
rs1421341653 151 dbSNP
rs541052413 151 dbSNP
rs1157590843 155 dbSNP
rs956512236 159 dbSNP
rs539198646 160 dbSNP
rs1378804986 161 dbSNP
rs3776101 169 dbSNP
rs1481045849 192 dbSNP
rs1268869032 193 dbSNP
rs1220687323 194 dbSNP
rs752176568 195 dbSNP
rs913570043 226 dbSNP
rs967800008 230 dbSNP
rs1204719507 231 dbSNP
rs979178982 232 dbSNP
rs566350918 235 dbSNP
rs1257829795 260 dbSNP
rs782345486 264 dbSNP
rs1224265089 266 dbSNP
rs3836746 270 dbSNP
rs397884075 270 dbSNP
rs1281346812 280 dbSNP
rs781846687 292 dbSNP
rs921049650 295 dbSNP
rs535385168 301 dbSNP
rs1340842853 317 dbSNP
rs1317392274 319 dbSNP
rs1398525455 327 dbSNP
rs1050939859 336 dbSNP
rs1403987584 348 dbSNP
rs1172637150 356 dbSNP
rs1468877240 360 dbSNP
rs1429158849 372 dbSNP
rs1197835445 374 dbSNP
rs1479097972 396 dbSNP
rs1193009217 397 dbSNP
rs1258590824 409 dbSNP
rs1204355016 427 dbSNP
rs782803488 438 dbSNP
rs1220325322 449 dbSNP
rs765716357 453 dbSNP
rs1269372014 455 dbSNP
rs1428448553 456 dbSNP
rs1341866721 457 dbSNP
rs1337024084 460 dbSNP
rs1451497850 461 dbSNP
rs1403197567 465 dbSNP
rs1172202757 471 dbSNP
rs1467642365 480 dbSNP
rs1167680152 483 dbSNP
rs1239615478 485 dbSNP
rs1474655074 485 dbSNP
rs1184387581 490 dbSNP
rs1461048206 491 dbSNP
rs553758428 492 dbSNP
rs1241281496 493 dbSNP
rs1200675881 499 dbSNP
rs782505204 502 dbSNP
rs1438305023 504 dbSNP
rs1218588118 510 dbSNP
rs1244706647 510 dbSNP
rs1272260372 510 dbSNP
rs1358149985 510 dbSNP
rs144560907 510 dbSNP
rs1332781372 512 dbSNP
rs1442364244 512 dbSNP
rs1037013617 513 dbSNP
rs1408739314 525 dbSNP
rs397815990 525 dbSNP
rs1416334088 526 dbSNP
rs1444229599 529 dbSNP
rs1383680013 534 dbSNP
rs1180559476 538 dbSNP
rs1470574639 539 dbSNP
rs1232402074 541 dbSNP
rs898495038 542 dbSNP
rs750789728 545 dbSNP
rs1202292543 567 dbSNP
rs186338579 570 dbSNP
rs1292229453 574 dbSNP
rs1221548773 575 dbSNP
rs1356796443 580 dbSNP
rs995518266 581 dbSNP
rs1044449668 584 dbSNP
rs1224025904 585 dbSNP
rs1371926099 587 dbSNP
rs536321398 590 dbSNP
rs1002976494 591 dbSNP
rs1368079770 592 dbSNP
rs556316552 596 dbSNP
rs1424478078 607 dbSNP
rs1363907231 608 dbSNP
rs1161500591 616 dbSNP
rs1401522763 617 dbSNP
rs1035846646 618 dbSNP
rs191927618 626 dbSNP
rs1478962588 640 dbSNP
rs1269586297 643 dbSNP
rs956286975 656 dbSNP
rs1489779553 659 dbSNP
rs181669087 661 dbSNP
rs1215994219 667 dbSNP
rs1315969648 672 dbSNP
rs186675581 674 dbSNP
rs1220510772 675 dbSNP
rs572257176 678 dbSNP
rs540936387 687 dbSNP
rs979131863 689 dbSNP
rs1343969414 705 dbSNP
rs1291011031 712 dbSNP
rs920995855 723 dbSNP
rs1454502277 725 dbSNP
rs1344893164 738 dbSNP
rs113891161 741 dbSNP
rs1156991199 759 dbSNP
rs35312684 780 dbSNP
rs1430111687 786 dbSNP
rs1175559292 788 dbSNP
rs1479424362 790 dbSNP
rs1263500776 792 dbSNP
rs986604186 802 dbSNP
rs1240049942 803 dbSNP
rs1485332526 803 dbSNP
rs1211572958 806 dbSNP
rs1323565252 807 dbSNP
rs1223368297 809 dbSNP
rs1298173668 821 dbSNP
rs1383180423 823 dbSNP
rs782455648 834 dbSNP
rs1287292730 837 dbSNP
rs912404998 842 dbSNP
rs1406848323 861 dbSNP
rs1336170145 864 dbSNP
rs939916209 870 dbSNP
rs1468162387 876 dbSNP
rs1374779265 883 dbSNP
rs1427746384 901 dbSNP
rs1184999600 908 dbSNP
rs1461500527 909 dbSNP
rs1241910661 915 dbSNP
rs1201294782 918 dbSNP
rs202246855 922 dbSNP
rs1253637702 926 dbSNP
rs1228833417 936 dbSNP
rs973070882 949 dbSNP
rs1307233869 953 dbSNP
rs919890155 957 dbSNP
rs191168447 964 dbSNP
rs549788663 967 dbSNP
rs563785811 986 dbSNP
rs1450600804 989 dbSNP
rs1398499831 1001 dbSNP
rs1298641019 1005 dbSNP
rs532536320 1010 dbSNP
rs938781240 1011 dbSNP
rs1057275321 1015 dbSNP
rs891962195 1019 dbSNP
rs1165242624 1028 dbSNP
rs1181182073 1033 dbSNP
rs1384278882 1033 dbSNP
rs1444853450 1033 dbSNP
rs1420313536 1040 dbSNP
rs1010453982 1053 dbSNP
rs1022292349 1060 dbSNP
rs1272931752 1063 dbSNP
rs1480596245 1063 dbSNP
rs904799816 1065 dbSNP
rs1314676605 1067 dbSNP
rs552732213 1069 dbSNP
rs1000522248 1070 dbSNP
rs1028005774 1077 dbSNP
rs953754468 1078 dbSNP
rs1390681599 1084 dbSNP
rs1371177605 1094 dbSNP
rs116397841 1097 dbSNP
rs1425111472 1098 dbSNP
rs377358993 1101 dbSNP
rs1161230013 1113 dbSNP
rs1019411790 1133 dbSNP
rs1180558598 1135 dbSNP
rs1418989380 1144 dbSNP
rs868979681 1145 dbSNP
rs1250307632 1148 dbSNP
rs782515629 1149 dbSNP
rs1490602975 1151 dbSNP
rs1291532185 1156 dbSNP
rs13178255 1162 dbSNP
rs1353115703 1165 dbSNP
rs577366306 1173 dbSNP
rs1333878491 1178 dbSNP
rs548917138 1180 dbSNP
rs931257127 1181 dbSNP
rs980041131 1192 dbSNP
rs1344578228 1193 dbSNP
rs782225840 1195 dbSNP
rs1383560116 1197 dbSNP
rs1385298271 1198 dbSNP
rs1157456772 1203 dbSNP
rs183010635 1256 dbSNP
rs536234002 1260 dbSNP
rs891912570 1266 dbSNP
rs1430824680 1270 dbSNP
rs1481058137 1276 dbSNP
rs946189203 1276 dbSNP
rs1268541724 1280 dbSNP
rs1043259614 1281 dbSNP
rs782006231 1292 dbSNP
rs1204809414 1298 dbSNP
rs1327104883 1304 dbSNP
rs35064210 1310 dbSNP
rs904748854 1314 dbSNP
rs1223976877 1325 dbSNP
rs1322824462 1329 dbSNP
rs782345257 1337 dbSNP
rs1229399124 1355 dbSNP
rs1326617995 1359 dbSNP
rs1027954963 1360 dbSNP
rs1317142858 1366 dbSNP
rs35528992 1379 dbSNP
rs1380187969 1381 dbSNP
rs1407579920 1391 dbSNP
rs1336824075 1400 dbSNP
rs1470585775 1401 dbSNP
rs545227362 1404 dbSNP
rs748225981 1420 dbSNP
rs1171155760 1434 dbSNP
rs1476571997 1444 dbSNP
rs1374016961 1448 dbSNP
rs1192671979 1449 dbSNP
rs1245043415 1452 dbSNP
rs1463720638 1452 dbSNP
rs1007930959 1457 dbSNP
rs1204455520 1461 dbSNP
rs1460801964 1463 dbSNP
rs1276462960 1472 dbSNP
rs1216285604 1475 dbSNP
rs1339767908 1478 dbSNP
rs1019781916 1481 dbSNP
rs1269388174 1486 dbSNP
rs1225640563 1488 dbSNP
rs186686639 1490 dbSNP
rs781941342 1503 dbSNP
rs1315119164 1516 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084047. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep4 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' guGCAGUCACUGACGCGGGGga 5'
            ||| ||  ||  ||||||  
Target 5' ggCGUGAGCCAC--CGCCCC-- 3'
7 - 24
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084047
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep4
Location of target site ENST00000194155.4 | 3UTR | AUUACAGGCGUGAGCCACCGCCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
67 hsa-miR-4697-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT441332 C19orf26 CACN beta subunit associated regulatory protein 2 4
MIRT451390 FARSA phenylalanyl-tRNA synthetase alpha subunit 2 2
MIRT452310 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT455043 MEN1 menin 1 2 2
MIRT455256 DDX39B DExD-box helicase 39B 2 10
MIRT461279 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT464945 TXLNA taxilin alpha 2 4
MIRT468043 SIK1 salt inducible kinase 1 2 2
MIRT472523 NACC1 nucleus accumbens associated 1 2 2
MIRT472929 MSN moesin 2 2
MIRT473247 MIDN midnolin 2 2
MIRT475828 HDGF heparin binding growth factor 2 2
MIRT478744 CS citrate synthase 2 2
MIRT480081 CALR calreticulin 2 2
MIRT483482 STMN3 stathmin 3 2 4
MIRT483643 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT483721 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT484539 BARHL1 BarH like homeobox 1 2 6
MIRT486041 WSCD1 WSC domain containing 1 2 4
MIRT486142 SIX5 SIX homeobox 5 2 6
MIRT486498 MYH11 myosin heavy chain 11 2 2
MIRT486977 STEAP3 STEAP3 metalloreductase 2 4
MIRT487279 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 4
MIRT487742 MIB2 mindbomb E3 ubiquitin protein ligase 2 2 2
MIRT487987 RXRB retinoid X receptor beta 2 2
MIRT488338 PAX2 paired box 2 2 2
MIRT488668 WWP2 WW domain containing E3 ubiquitin protein ligase 2 2 4
MIRT488752 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT488812 TBC1D28 TBC1 domain family member 28 2 2
MIRT489380 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT489744 TACC3 transforming acidic coiled-coil containing protein 3 2 2
MIRT489960 GNB2 G protein subunit beta 2 2 2
MIRT490418 VPS51 VPS51, GARP complex subunit 2 4
MIRT490639 FEM1A fem-1 homolog A 2 2
MIRT491086 MSI1 musashi RNA binding protein 1 2 4
MIRT491298 VGF VGF nerve growth factor inducible 2 4
MIRT491366 SLC12A5 solute carrier family 12 member 5 2 2
MIRT492464 RASD1 ras related dexamethasone induced 1 2 4
MIRT492872 NFIX nuclear factor I X 2 2
MIRT492951 NEUROD2 neuronal differentiation 2 2 2
MIRT493704 H2AFX H2A histone family member X 2 2
MIRT493977 EIF1 eukaryotic translation initiation factor 1 2 4
MIRT500360 ZNF385A zinc finger protein 385A 2 2
MIRT501154 SLC10A7 solute carrier family 10 member 7 2 6
MIRT509625 RRP7A ribosomal RNA processing 7 homolog A 2 4
MIRT512232 ATG2A autophagy related 2A 2 8
MIRT529822 ARGFX arginine-fifty homeobox 2 4
MIRT531179 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT538971 BCL7A BCL tumor suppressor 7A 2 2
MIRT548357 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 4
MIRT553634 TJAP1 tight junction associated protein 1 2 2
MIRT558050 EVI5L ecotropic viral integration site 5 like 2 2
MIRT562548 CCDC71L coiled-coil domain containing 71 like 2 4
MIRT568941 RUNX3 runt related transcription factor 3 2 2
MIRT569114 ONECUT3 one cut homeobox 3 2 2
MIRT573591 CERS1 ceramide synthase 1 2 2
MIRT619317 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT621202 ARPC1B actin related protein 2/3 complex subunit 1B 2 2
MIRT628844 FAM151B family with sequence similarity 151 member B 2 2
MIRT670497 LYRM4 LYR motif containing 4 2 2
MIRT670545 SHISA2 shisa family member 2 2 2
MIRT671026 PCDHB2 protocadherin beta 2 2 2
MIRT688989 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT709275 MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2 2
MIRT715084 ELOF1 elongation factor 1 homolog 2 2
MIRT718348 NPBWR1 neuropeptides B and W receptor 1 2 2
MIRT737406 MMP7 matrix metallopeptidase 7 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4697 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4697-5p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4697-5p Paclitaxel 36314 NSC125973 approved resistant High Breast Cancer cell line (Bads-200, Bats-72, BCap37)
hsa-miR-4697-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (total RNA)
hsa-miR-4697-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-4697-5p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-4697-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4697-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4697-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4697-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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