miRTarBase - #MIRT671290


—
pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RPL37A   
Synonyms L37A
Description ribosomal protein L37a
Transcript NM_000998   
Expression
Putative miRNA Targets on RPL37A
3'UTR of RPL37A
(miRNA target sites are highlighted)		 
>RPL37A|NM_000998|3'UTR
   1 ACGCTCCTCTACTCTTTGAGACATCACTGGCCTATAATAAATGGGTTAATTTATGTAACAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acgGUCG-GAGCGGGUcg 5'
             || | || |||:|  
Target 5' agaCATCACTGGCCTAta 3'
 19 - 36 86.00 -8.17
2 
miRNA  3' acggucggaGCGGGucg 5'
                   |||:|   
Target 5' --------aCGCTCctc 3'
 1 - 9 84.00 -6.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN17253410 19 COSMIC
COSN31527277 27 COSMIC
COSN31502247 28 COSMIC
COSN26581771 30 COSMIC
COSN22215818 797 COSMIC
COSN9873950 1250 COSMIC
COSN26896049 1324 COSMIC
COSN30060165 1397 COSMIC
COSN1824689 1432 COSMIC
COSN15779543 1496 COSMIC
COSN5788733 1764 COSMIC
COSN15747622 2099 COSMIC
COSN21843178 2125 COSMIC
COSN21955785 2141 COSMIC
COSN21114961 2204 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs771228983 2 dbSNP
rs771829140 3 dbSNP
rs186204060 4 dbSNP
rs760083628 5 dbSNP
rs966489387 7 dbSNP
rs1348992420 8 dbSNP
rs569360685 11 dbSNP
rs775614668 12 dbSNP
rs775229852 14 dbSNP
rs1225058717 15 dbSNP
rs1195839045 17 dbSNP
rs1414362101 18 dbSNP
rs973213209 25 dbSNP
rs1332799947 26 dbSNP
rs763008368 27 dbSNP
rs1453830088 28 dbSNP
rs1210590356 31 dbSNP
rs764178869 35 dbSNP
rs371360227 37 dbSNP
rs15522 38 dbSNP
rs1313701948 43 dbSNP
rs757464370 51 dbSNP
rs766112795 52 dbSNP
rs1344424168 53 dbSNP
rs1340016417 55 dbSNP
rs540069493 61 dbSNP
rs1278916866 62 dbSNP
rs780910108 68 dbSNP
rs981567765 74 dbSNP
rs927538701 77 dbSNP
rs1292478526 78 dbSNP
rs1302736156 80 dbSNP
rs745685617 81 dbSNP
rs572454544 86 dbSNP
rs558382341 91 dbSNP
rs1361204106 93 dbSNP
rs1167951076 119 dbSNP
rs949544070 120 dbSNP
rs1423763724 127 dbSNP
rs1172161027 137 dbSNP
rs982280314 141 dbSNP
rs573499886 143 dbSNP
rs769398260 149 dbSNP
rs918670751 153 dbSNP
rs914878984 154 dbSNP
rs1484122012 158 dbSNP
rs930024670 159 dbSNP
rs1351416354 161 dbSNP
rs74463622 163 dbSNP
rs775170922 164 dbSNP
rs1220568476 166 dbSNP
rs1323771783 167 dbSNP
rs1332682467 167 dbSNP
rs1042138587 182 dbSNP
rs902232773 194 dbSNP
rs1291201501 196 dbSNP
rs555737461 198 dbSNP
rs1296776939 203 dbSNP
rs1357384845 207 dbSNP
rs933836483 208 dbSNP
rs762357152 226 dbSNP
rs889750812 227 dbSNP
rs1332911324 243 dbSNP
rs1459422106 249 dbSNP
rs1367324010 251 dbSNP
rs768276944 252 dbSNP
rs1016963648 253 dbSNP
rs1177753252 255 dbSNP
rs1458008482 261 dbSNP
rs1482580071 265 dbSNP
rs573602685 268 dbSNP
rs1257800336 270 dbSNP
rs1264932373 271 dbSNP
rs1424100349 277 dbSNP
rs1246216670 278 dbSNP
rs1324002966 281 dbSNP
rs543771165 285 dbSNP
rs1382791299 291 dbSNP
rs201923364 292 dbSNP
rs994156262 293 dbSNP
rs1170988542 296 dbSNP
rs1025734764 299 dbSNP
rs971437223 309 dbSNP
rs773737728 310 dbSNP
rs1034512943 311 dbSNP
rs999246405 311 dbSNP
rs868616119 313 dbSNP
rs1440091095 314 dbSNP
rs1180817973 319 dbSNP
rs75047404 319 dbSNP
rs555774744 323 dbSNP
rs577295539 330 dbSNP
rs1381597249 341 dbSNP
rs1396760513 342 dbSNP
rs1284514686 343 dbSNP
rs772236151 345 dbSNP
rs1380618534 347 dbSNP
rs1230737264 349 dbSNP
rs780646117 349 dbSNP
rs1231677503 351 dbSNP
rs544849372 351 dbSNP
rs1275241994 353 dbSNP
rs1330129450 366 dbSNP
rs1306891416 369 dbSNP
rs914807104 371 dbSNP
rs113543896 372 dbSNP
rs559904527 376 dbSNP
rs1024300222 380 dbSNP
rs970994003 381 dbSNP
rs1202179578 387 dbSNP
rs1359179055 388 dbSNP
rs74616221 392 dbSNP
rs977694451 395 dbSNP
rs1362261904 397 dbSNP
rs1180853022 399 dbSNP
rs1240921915 401 dbSNP
rs923728928 405 dbSNP
rs1377311115 406 dbSNP
rs1188685150 408 dbSNP
rs1391319957 417 dbSNP
rs1434998738 422 dbSNP
rs1409952730 423 dbSNP
rs933742219 428 dbSNP
rs1261112321 429 dbSNP
rs930160497 434 dbSNP
rs984591620 441 dbSNP
rs190572009 446 dbSNP
rs560992835 452 dbSNP
rs1344705061 454 dbSNP
rs1256231967 456 dbSNP
rs1336262635 458 dbSNP
rs942517794 461 dbSNP
rs1038709278 462 dbSNP
rs1276983982 463 dbSNP
rs760015096 467 dbSNP
rs1310949399 470 dbSNP
rs529324482 471 dbSNP
rs765538226 472 dbSNP
rs1298511863 474 dbSNP
rs994174812 477 dbSNP
rs1421632391 500 dbSNP
rs1276880527 501 dbSNP
rs1025643035 502 dbSNP
rs1478162355 506 dbSNP
rs1212677627 507 dbSNP
rs114826840 510 dbSNP
rs1442264828 515 dbSNP
rs1257295383 516 dbSNP
rs1312515393 517 dbSNP
rs1315658248 524 dbSNP
rs1256972575 527 dbSNP
rs1202822943 532 dbSNP
rs1002939540 539 dbSNP
rs753030573 543 dbSNP
rs902324242 544 dbSNP
rs1260830473 550 dbSNP
rs758405525 551 dbSNP
rs569423001 552 dbSNP
rs777845346 554 dbSNP
rs990295332 556 dbSNP
rs1053933105 558 dbSNP
rs1208794685 559 dbSNP
rs1398061669 576 dbSNP
rs1398406428 586 dbSNP
rs1330885838 588 dbSNP
rs1240952459 589 dbSNP
rs1425796234 594 dbSNP
rs1022303611 598 dbSNP
rs1472738004 599 dbSNP
rs1369456484 602 dbSNP
rs114573688 604 dbSNP
rs977769622 614 dbSNP
rs1427890825 616 dbSNP
rs1456684520 617 dbSNP
rs757172149 619 dbSNP
rs1023219860 621 dbSNP
rs781139138 624 dbSNP
rs1176215881 626 dbSNP
rs1427459808 627 dbSNP
rs371446015 629 dbSNP
rs923591254 632 dbSNP
rs955155097 633 dbSNP
rs1458758685 637 dbSNP
rs1287130367 639 dbSNP
rs183539188 644 dbSNP
rs1344614839 646 dbSNP
rs1356941840 647 dbSNP
rs112665637 649 dbSNP
rs115600941 651 dbSNP
rs1375790512 652 dbSNP
rs1308821459 659 dbSNP
rs984338263 660 dbSNP
rs77042765 661 dbSNP
rs370222353 662 dbSNP
rs919871189 662 dbSNP
rs964120732 662 dbSNP
rs1281206689 663 dbSNP
rs1438236813 669 dbSNP
rs1380058455 672 dbSNP
rs1330964981 681 dbSNP
rs1178943126 695 dbSNP
rs879905940 697 dbSNP
rs1220219850 725 dbSNP
rs1451637165 728 dbSNP
rs922567589 730 dbSNP
rs929875279 731 dbSNP
rs1352790265 736 dbSNP
rs1286426650 738 dbSNP
rs1241210233 739 dbSNP
rs1047117133 740 dbSNP
rs907189269 741 dbSNP
rs1435848226 745 dbSNP
rs1223189341 749 dbSNP
rs923883492 752 dbSNP
rs1002851355 753 dbSNP
rs1056285092 757 dbSNP
rs1490676851 758 dbSNP
rs1053665911 760 dbSNP
rs1427571059 761 dbSNP
rs537474974 764 dbSNP
rs893634505 766 dbSNP
rs1247936234 767 dbSNP
rs555735838 768 dbSNP
rs769634369 769 dbSNP
rs577356493 770 dbSNP
rs1286588970 776 dbSNP
rs1218559702 777 dbSNP
rs1310147163 781 dbSNP
rs1021794738 782 dbSNP
rs144312540 785 dbSNP
rs1345884350 788 dbSNP
rs201453908 788 dbSNP
rs999052793 790 dbSNP
rs1167086042 795 dbSNP
rs1340479604 795 dbSNP
rs1350383347 797 dbSNP
rs1299305922 799 dbSNP
rs1030513803 804 dbSNP
rs1003188831 805 dbSNP
rs1357728404 809 dbSNP
rs1174987909 811 dbSNP
rs1388119711 814 dbSNP
rs1025842310 824 dbSNP
rs951699669 825 dbSNP
rs559942163 828 dbSNP
rs1167941233 829 dbSNP
rs1006217128 832 dbSNP
rs1352053494 834 dbSNP
rs1410229863 836 dbSNP
rs986387593 837 dbSNP
rs1195677561 838 dbSNP
rs964571871 846 dbSNP
rs187876768 848 dbSNP
rs748901917 850 dbSNP
rs542445625 851 dbSNP
rs974351684 853 dbSNP
rs1443195274 855 dbSNP
rs561266117 856 dbSNP
rs1229537075 865 dbSNP
rs1317302831 866 dbSNP
rs3108223 869 dbSNP
rs1358127529 871 dbSNP
rs1216818804 873 dbSNP
rs1377524864 875 dbSNP
rs923852458 878 dbSNP
rs192353890 879 dbSNP
rs1328784321 882 dbSNP
rs1464658066 883 dbSNP
rs562880380 886 dbSNP
rs1172524566 888 dbSNP
rs1267420570 890 dbSNP
rs1047033001 893 dbSNP
rs115106507 894 dbSNP
rs938673385 895 dbSNP
rs551927300 896 dbSNP
rs773859053 899 dbSNP
rs1044776933 900 dbSNP
rs566817181 902 dbSNP
rs58740843 910 dbSNP
rs796741861 910 dbSNP
rs894592743 914 dbSNP
rs1258791858 919 dbSNP
rs1046672416 920 dbSNP
rs566996863 920 dbSNP
rs773188237 920 dbSNP
rs939016249 920 dbSNP
rs1011644390 928 dbSNP
rs1424131146 929 dbSNP
rs1445571790 938 dbSNP
rs1043649010 939 dbSNP
rs903377446 942 dbSNP
rs998953206 949 dbSNP
rs771530087 950 dbSNP
rs1165318892 951 dbSNP
rs1446240941 957 dbSNP
rs1378238506 960 dbSNP
rs1030540348 961 dbSNP
rs770446414 967 dbSNP
rs955481410 967 dbSNP
rs1489327289 970 dbSNP
rs977507078 975 dbSNP
rs1179056067 979 dbSNP
rs534438040 979 dbSNP
rs954922764 984 dbSNP
rs549288238 988 dbSNP
rs772190390 996 dbSNP
rs957615933 1006 dbSNP
rs1284280518 1010 dbSNP
rs1239038574 1012 dbSNP
rs1008340556 1016 dbSNP
rs1384577274 1024 dbSNP
rs1017936033 1035 dbSNP
rs1294101705 1037 dbSNP
rs989391281 1040 dbSNP
rs1358434154 1041 dbSNP
rs867038822 1044 dbSNP
rs1420040338 1051 dbSNP
rs373875301 1053 dbSNP
rs1026706411 1055 dbSNP
rs146478462 1058 dbSNP
rs538138143 1063 dbSNP
rs939068523 1065 dbSNP
rs1272670241 1070 dbSNP
rs1490976626 1070 dbSNP
rs1216387846 1076 dbSNP
rs182880683 1078 dbSNP
rs1046809965 1086 dbSNP
rs570910745 1087 dbSNP
rs1189829207 1088 dbSNP
rs1243996756 1090 dbSNP
rs982578462 1091 dbSNP
rs941046871 1095 dbSNP
rs773273601 1096 dbSNP
rs60236404 1098 dbSNP
rs1400396821 1101 dbSNP
rs1386853832 1103 dbSNP
rs547922753 1110 dbSNP
rs1391939067 1114 dbSNP
rs991924684 1114 dbSNP
rs765768165 1116 dbSNP
rs1464702369 1119 dbSNP
rs753010847 1120 dbSNP
rs1167278865 1127 dbSNP
rs1393984639 1128 dbSNP
rs1415992658 1132 dbSNP
rs1193507378 1135 dbSNP
rs1448000969 1141 dbSNP
rs3087590 1144 dbSNP
rs891309170 1146 dbSNP
rs16856272 1160 dbSNP
rs1032193631 1161 dbSNP
rs751617902 1162 dbSNP
rs957377857 1163 dbSNP
rs1365310363 1167 dbSNP
rs1277554257 1169 dbSNP
rs776440183 1173 dbSNP
rs1328018555 1174 dbSNP
rs990587388 1176 dbSNP
rs934835417 1178 dbSNP
rs1270159927 1181 dbSNP
rs542856607 1182 dbSNP
rs1337565197 1189 dbSNP
rs890744944 1192 dbSNP
rs1007790514 1193 dbSNP
rs1398192040 1195 dbSNP
rs1018385721 1198 dbSNP
rs899509787 1202 dbSNP
rs1263951744 1206 dbSNP
rs995542121 1214 dbSNP
rs547719251 1221 dbSNP
rs980662241 1223 dbSNP
rs187481381 1232 dbSNP
rs927771830 1233 dbSNP
rs149662432 1234 dbSNP
rs939205838 1235 dbSNP
rs1411172048 1245 dbSNP
rs1461088648 1250 dbSNP
rs192950767 1252 dbSNP
rs1282315293 1253 dbSNP
rs1201842558 1254 dbSNP
rs1243805585 1255 dbSNP
rs759146122 1256 dbSNP
rs1249919494 1258 dbSNP
rs1026742798 1267 dbSNP
rs570633429 1269 dbSNP
rs370312328 1272 dbSNP
rs1454777838 1273 dbSNP
rs1398256894 1278 dbSNP
rs908317688 1283 dbSNP
rs941029270 1284 dbSNP
rs1399300898 1289 dbSNP
rs543744672 1292 dbSNP
rs1035506462 1293 dbSNP
rs184650290 1296 dbSNP
rs1428160888 1298 dbSNP
rs1386241689 1302 dbSNP
rs752218732 1302 dbSNP
rs991437262 1306 dbSNP
rs1437410700 1321 dbSNP
rs915792452 1324 dbSNP
rs1322141424 1325 dbSNP
rs932856384 1326 dbSNP
rs1209153188 1328 dbSNP
rs1384998383 1330 dbSNP
rs1051360787 1336 dbSNP
rs1293638355 1337 dbSNP
rs891277704 1342 dbSNP
rs1318219812 1348 dbSNP
rs1325239031 1357 dbSNP
rs1374988261 1357 dbSNP
rs1235875948 1358 dbSNP
rs1284391359 1368 dbSNP
rs999050382 1369 dbSNP
rs947409438 1370 dbSNP
rs893246793 1373 dbSNP
rs1270291516 1377 dbSNP
rs1486207901 1378 dbSNP
rs1379305860 1379 dbSNP
rs76685375 1381 dbSNP
rs1259536001 1383 dbSNP
rs1453325156 1389 dbSNP
rs1244471646 1391 dbSNP
rs1023351631 1392 dbSNP
rs970043069 1394 dbSNP
rs924730777 1396 dbSNP
rs934741952 1401 dbSNP
rs1267828829 1404 dbSNP
rs1051904669 1406 dbSNP
rs1214222955 1408 dbSNP
rs1283894625 1408 dbSNP
rs1352629898 1408 dbSNP
rs1224533911 1412 dbSNP
rs890609655 1413 dbSNP
rs1352980067 1420 dbSNP
rs1346729308 1422 dbSNP
rs1404357885 1422 dbSNP
rs943504119 1424 dbSNP
rs545057686 1429 dbSNP
rs1344963078 1435 dbSNP
rs560663306 1436 dbSNP
rs879097581 1437 dbSNP
rs1422506454 1443 dbSNP
rs1171512619 1446 dbSNP
rs527778853 1450 dbSNP
rs373641622 1454 dbSNP
rs1487876569 1455 dbSNP
rs556607307 1460 dbSNP
rs1407236247 1461 dbSNP
rs962737730 1465 dbSNP
rs886881098 1471 dbSNP
rs549593038 1484 dbSNP
rs567770152 1486 dbSNP
rs1003954182 1487 dbSNP
rs757890804 1488 dbSNP
rs768079697 1490 dbSNP
rs1271113938 1491 dbSNP
rs141432349 1492 dbSNP
rs1433271644 1494 dbSNP
rs139907822 1497 dbSNP
rs879017947 1499 dbSNP
rs1051331661 1501 dbSNP
rs756594454 1504 dbSNP
rs1013126740 1505 dbSNP
rs1317787390 1507 dbSNP
rs780312251 1512 dbSNP
rs1022887422 1520 dbSNP
rs1238419571 1528 dbSNP
rs550080224 1533 dbSNP
rs912849327 1538 dbSNP
rs969030148 1548 dbSNP
rs535839905 1552 dbSNP
rs1471649788 1554 dbSNP
rs1235958578 1565 dbSNP
rs978770086 1567 dbSNP
rs924594550 1570 dbSNP
rs1197358864 1571 dbSNP
rs571595079 1573 dbSNP
rs1296876453 1576 dbSNP
rs956152214 1578 dbSNP
rs1216698265 1580 dbSNP
rs779132623 1580 dbSNP
rs987527886 1582 dbSNP
rs911940783 1585 dbSNP
rs943557901 1586 dbSNP
rs1452871363 1587 dbSNP
rs1384419015 1591 dbSNP
rs1328709174 1594 dbSNP
rs1489788564 1595 dbSNP
rs1012044153 1597 dbSNP
rs538277650 1599 dbSNP
rs1039603896 1604 dbSNP
rs367850281 1612 dbSNP
rs1403453048 1618 dbSNP
rs1418203456 1619 dbSNP
rs1384376147 1622 dbSNP
rs920896565 1626 dbSNP
rs1044503022 1628 dbSNP
rs1445441490 1642 dbSNP
rs1245145949 1647 dbSNP
rs1369627003 1651 dbSNP
rs1175591427 1657 dbSNP
rs1480314130 1659 dbSNP
rs905853642 1660 dbSNP
rs1002857126 1662 dbSNP
rs930873882 1664 dbSNP
rs1320332194 1665 dbSNP
rs1291469298 1674 dbSNP
rs1397625575 1676 dbSNP
rs1247106012 1677 dbSNP
rs1361184767 1679 dbSNP
rs1424783797 1679 dbSNP
rs1390326873 1686 dbSNP
rs1373411094 1687 dbSNP
rs1299883555 1689 dbSNP
rs1164726161 1692 dbSNP
rs189107226 1693 dbSNP
rs1048120209 1698 dbSNP
rs1364788807 1700 dbSNP
rs1164003444 1701 dbSNP
rs1365561471 1706 dbSNP
rs1426274195 1712 dbSNP
rs886788228 1717 dbSNP
rs1003860985 1722 dbSNP
rs1387321607 1736 dbSNP
rs1157124516 1740 dbSNP
rs1423097788 1742 dbSNP
rs1418641780 1748 dbSNP
rs1034891979 1749 dbSNP
rs1374313448 1751 dbSNP
rs960650308 1757 dbSNP
rs192093687 1761 dbSNP
rs749598315 1762 dbSNP
rs143415002 1763 dbSNP
rs1223693925 1770 dbSNP
rs1490926368 1779 dbSNP
rs1283508871 1780 dbSNP
rs1237869952 1782 dbSNP
rs12616410 1786 dbSNP
rs572108631 1787 dbSNP
rs184185207 1796 dbSNP
rs921039943 1801 dbSNP
rs1303622415 1804 dbSNP
rs115049945 1807 dbSNP
rs1358380061 1814 dbSNP
rs986501153 1815 dbSNP
rs1000054678 1816 dbSNP
rs138122943 1820 dbSNP
rs934872613 1820 dbSNP
rs747668950 1821 dbSNP
rs1161409758 1822 dbSNP
rs987393514 1824 dbSNP
rs771769433 1830 dbSNP
rs989088739 1832 dbSNP
rs1200764970 1833 dbSNP
rs965154638 1835 dbSNP
rs974962559 1846 dbSNP
rs148903451 1854 dbSNP
rs746313286 1863 dbSNP
rs560276967 1867 dbSNP
rs189370028 1869 dbSNP
rs181971649 1871 dbSNP
rs186178734 1876 dbSNP
rs930771871 1879 dbSNP
rs1048027969 1882 dbSNP
rs1322145812 1885 dbSNP
rs1283918454 1887 dbSNP
rs947602593 1892 dbSNP
rs542756839 1909 dbSNP
rs561015864 1921 dbSNP
rs1257868049 1925 dbSNP
rs1382531496 1933 dbSNP
rs1044445009 1935 dbSNP
rs1290795197 1939 dbSNP
rs905990891 1940 dbSNP
rs1405431869 1945 dbSNP
rs938681311 1950 dbSNP
rs1444698185 1951 dbSNP
rs1182490089 1952 dbSNP
rs775876900 1957 dbSNP
rs1057021755 1962 dbSNP
rs939678647 1965 dbSNP
rs1263430719 1968 dbSNP
rs1173182708 1970 dbSNP
rs1355437738 1973 dbSNP
rs763260746 1974 dbSNP
rs1204960656 1977 dbSNP
rs1057191703 1979 dbSNP
rs1250620454 1988 dbSNP
rs1227898864 1989 dbSNP
rs895603061 1994 dbSNP
rs1004565070 1999 dbSNP
rs752464408 2001 dbSNP
rs1382188764 2002 dbSNP
rs1337498560 2007 dbSNP
rs1470975074 2011 dbSNP
rs1394974288 2014 dbSNP
rs764412409 2015 dbSNP
rs75764470 2020 dbSNP
rs774487022 2021 dbSNP
rs1181415356 2022 dbSNP
rs1443613033 2028 dbSNP
rs773334894 2029 dbSNP
rs1243328130 2031 dbSNP
rs904367210 2034 dbSNP
rs1216185807 2035 dbSNP
rs999961279 2040 dbSNP
rs1249801271 2046 dbSNP
rs1196301519 2047 dbSNP
rs761876093 2051 dbSNP
rs986542093 2055 dbSNP
rs1244913560 2060 dbSNP
rs1019321987 2061 dbSNP
rs955717126 2067 dbSNP
rs1450315113 2072 dbSNP
rs1412255942 2074 dbSNP
rs1264588549 2075 dbSNP
rs549943736 2078 dbSNP
rs571657194 2080 dbSNP
rs767518874 2084 dbSNP
rs1019345909 2085 dbSNP
rs1465885277 2087 dbSNP
rs1188752919 2092 dbSNP
rs1385485949 2099 dbSNP
rs964854223 2101 dbSNP
rs532687431 2102 dbSNP
rs1182498133 2104 dbSNP
rs927463325 2111 dbSNP
rs1431693763 2114 dbSNP
rs80111148 2115 dbSNP
rs1221471012 2116 dbSNP
rs757039405 2117 dbSNP
rs565544402 2124 dbSNP
rs1057129419 2127 dbSNP
rs1292854172 2130 dbSNP
rs1470390933 2131 dbSNP
rs189085933 2134 dbSNP
rs143424427 2138 dbSNP
rs1037366909 2140 dbSNP
rs983587443 2144 dbSNP
rs562600575 2150 dbSNP
rs1301771786 2151 dbSNP
rs908156992 2152 dbSNP
rs75050242 2153 dbSNP
rs1366577302 2154 dbSNP
rs1028196955 2158 dbSNP
rs1361239480 2161 dbSNP
rs1212583482 2164 dbSNP
rs1285022723 2169 dbSNP
rs73074158 2172 dbSNP
rs1158675255 2174 dbSNP
rs558781378 2175 dbSNP
rs1427133526 2179 dbSNP
rs1198585108 2180 dbSNP
rs948383585 2182 dbSNP
rs577249100 2188 dbSNP
rs1215936609 2191 dbSNP
rs150935220 2195 dbSNP
rs935844404 2196 dbSNP
rs766332732 2197 dbSNP
rs1271411121 2198 dbSNP
rs1052881466 2199 dbSNP
rs553183888 2203 dbSNP
rs1282002563 2207 dbSNP
rs372847726 2212 dbSNP
rs1346589888 2218 dbSNP
rs375435897 2224 dbSNP
rs980314223 2228 dbSNP
rs1175919681 2229 dbSNP
rs927494333 2232 dbSNP
rs1018835341 2236 dbSNP
rs960178397 2237 dbSNP
rs542971169 2242 dbSNP
rs77233212 2243 dbSNP
rs907923015 2244 dbSNP
rs940693774 2246 dbSNP
rs996154953 2248 dbSNP
rs1241799575 2250 dbSNP
rs1028163848 2254 dbSNP
rs1466340242 2260 dbSNP
rs1261310302 2262 dbSNP
rs1037667211 2263 dbSNP
rs920586403 2276 dbSNP
rs1428485896 2284 dbSNP
rs1304887196 2291 dbSNP
rs754773848 2295 dbSNP
rs983656518 2300 dbSNP
rs1015080615 2303 dbSNP
rs960975327 2310 dbSNP
rs1404160259 2313 dbSNP
rs1280936900 2315 dbSNP
rs1270480051 2319 dbSNP
rs931249769 2319 dbSNP
rs1380005182 2325 dbSNP
rs992832647 2330 dbSNP
rs796613231 2332 dbSNP
rs948392807 2334 dbSNP
rs373515747 2335 dbSNP
rs371680956 2339 dbSNP
rs935734480 2343 dbSNP
rs1451582250 2352 dbSNP
rs185666140 2358 dbSNP
rs913081523 2363 dbSNP
rs747825282 2364 dbSNP
rs1461781185 2369 dbSNP
rs375278372 2373 dbSNP
rs1021324981 2377 dbSNP
rs968775943 2384 dbSNP
rs944533910 2406 dbSNP
rs1040698513 2410 dbSNP
rs1245201912 2414 dbSNP
rs1307327523 2414 dbSNP
rs1231012224 2420 dbSNP
rs543650553 2430 dbSNP
rs1471313415 2434 dbSNP
rs565148634 2448 dbSNP
rs1001763872 2454 dbSNP
rs1034538626 2458 dbSNP
rs960209315 2459 dbSNP
rs532694233 2462 dbSNP
rs996616552 2464 dbSNP
rs1399061895 2466 dbSNP
rs547798883 2481 dbSNP
rs284540 2489 dbSNP
rs1416016050 2492 dbSNP
rs757662863 2503 dbSNP
rs1480606762 2517 dbSNP
rs138350218 2525 dbSNP
rs1207753060 2531 dbSNP
rs1014985970 2542 dbSNP
rs777363738 2547 dbSNP
rs114493961 2550 dbSNP
rs764930089 2554 dbSNP
rs527307817 2556 dbSNP
rs1222665866 2557 dbSNP
rs371599886 2557 dbSNP
rs1040923830 2560 dbSNP
rs1373972028 2562 dbSNP
rs1247601214 2566 dbSNP
rs775901922 2586 dbSNP
rs1402934936 2587 dbSNP
rs1364730270 2592 dbSNP
rs749643475 2597 dbSNP
rs1302822159 2598 dbSNP
rs1458585975 2599 dbSNP
rs775119683 2613 dbSNP
rs1317744352 2622 dbSNP
rs1360882341 2623 dbSNP
rs569813236 2624 dbSNP
rs1418515213 2641 dbSNP
rs1413367767 2648 dbSNP
rs537132543 2649 dbSNP
rs1184958279 2650 dbSNP
rs1479682015 2652 dbSNP
rs980199883 2655 dbSNP
rs925609111 2657 dbSNP
rs1489275280 2661 dbSNP
rs1214474616 2663 dbSNP
rs957007640 2663 dbSNP
rs552260655 2669 dbSNP
rs576910631 2670 dbSNP
rs1043180213 2678 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acGGUCGGAGCGGGUCg 5'
            ||| || ||||||| 
Target 5' agCCA-CCACGCCCAGc 3'
 		15 - 30
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000491306.1 | 3UTR | GGAUUACAGGUGUGAGCCACCACGCCCAGCCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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