miRTarBase - #MIRT672046


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pre-miRNA Information
pre-miRNA hsa-mir-3937   
Genomic Coordinates chrX: 39661216 - 39661321
Description Homo sapiens miR-3937 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3937
Sequence 61| ACAGGCGGCUGUAGCAAUGGGGG |83
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1430604115 6 dbSNP
rs776622162 7 dbSNP
rs1283731816 11 dbSNP
rs1029784871 13 dbSNP
rs750525479 20 dbSNP
rs956488517 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SMTNL2   
Synonyms -
Description smoothelin like 2
Transcript NM_001114974   
Other Transcripts NM_198501   
Expression
Putative miRNA Targets on SMTNL2
3'UTR of SMTNL2
(miRNA target sites are highlighted)		 
>SMTNL2|NM_001114974|3'UTR
   1 AGCCCCTGAGCCTGGATTGCCAAAGAGCAGCCCCAGGAAGAGGCCGGGGGTCCGCTTGCGATTCCCCAGCCAGGATGCCC
  81 CCAGGAGCCTTGCCGTTTGGTGTGAGCGCGCTGTTTGTTCTGTGGCATGTGACGGCACTCCCCTTCGAGCCCAGCTGTGT
 161 TACTGATTAAAAGTACTGCTGAGCTGTGGTCCGACAGCACTGATCACAGCCAAGGGCTTGGAGGAAAAGGAAAAATTATG
 241 AGAGAGAGAGAGACATTGGTGCTAAGTAATGATCTTCCTAAAGAAATGCTTGTGTTTATAGCTTCCAGAATGCTAATCTA
 321 CAATTTTCCCTCTGGTGAATTCGATACATCGGCTTTACAGGGTTACAGTGATTACCAAGTGTTTTTTTTTATCAAAATAC
 401 CCAGAGTTTTTTACTTCCTCACGCGATTGTAGGTTCCTCTCCTCCCTCCCTCTGGGCCACTGCCAGGAAACAGAGAGACC
 481 GCTTAATCAGCAGCTTGACAAAGAAGACCTCAAGTCTTGGGAAGAAACAGTTTAATCACTCCCAAGTCCTGGGCAACAGA
 561 TGACCTTCAAGTCACCTCCGCTCTCCGGGGAGATGGGAAGGCTCTCCTCTCGGTCCCAAAGTCCTCCTGTTCTTCCCAGG
 641 AGGCCCCACAAGTGTTTGGCTAAGCACAGGCTCTCGGGAATTTAACACTTTTGGGGAAGGAATAGGCCCTTTGTGCTGAG
 721 AGAGAGTTTTTATTCACATCTTTTTTAGGGGATTTGCTGCAGATATTTATAAAAAGTAACTCCCTCTGTACCACTGACCC
 801 ATTTATACATAAAAAAGATGTGTTGAATTTTG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ggggguaaCGAUGUC--GGCGGACa 5'
                  || : :|  ||||:|| 
Target 5' aggaagagGCCGGGGGTCCGCTTGc 3'
 35 - 59 125.00 -14.50
2 
miRNA  3' ggGGGUAACGAUGUC-GGCGGACa 5'
            |:|: | | | || || |||| 
Target 5' ctCTCGGTCCCAAAGTCCTCCTGt 3'
 607 - 630 125.00 -16.24
3 
miRNA  3' gggGGUAACG-----AUGUC-----GGCGGAca 5'
             ||| |||      ||||     ||||:|  
Target 5' gggCCACTGCCAGGAAACAGAGAGACCGCTTaa 3'
 454 - 486 116.00 -14.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30106229 4 COSMIC
COSN31513667 7 COSMIC
COSN6104901 21 COSMIC
COSN30475966 35 COSMIC
COSN24314168 41 COSMIC
COSN30455522 46 COSMIC
COSN30512499 47 COSMIC
COSN30185325 54 COSMIC
COSN31565817 55 COSMIC
COSN28855074 60 COSMIC
COSN31488458 105 COSMIC
COSN216923 109 COSMIC
COSN31520604 249 COSMIC
COSN31488485 251 COSMIC
COSN31602688 254 COSMIC
COSN22391352 363 COSMIC
COSN20113310 391 COSMIC
COSN8242983 447 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1203926965 4 dbSNP
rs771496227 5 dbSNP
rs372300179 12 dbSNP
rs774827351 27 dbSNP
rs549460920 29 dbSNP
rs767601573 32 dbSNP
rs775391185 34 dbSNP
rs760973903 38 dbSNP
rs1427107658 43 dbSNP
rs1213814243 44 dbSNP
rs764161178 46 dbSNP
rs374329102 47 dbSNP
rs1291118523 48 dbSNP
rs1424611808 49 dbSNP
rs964634414 54 dbSNP
rs975068397 55 dbSNP
rs1243575995 60 dbSNP
rs569601588 61 dbSNP
rs535545076 63 dbSNP
rs1490422171 71 dbSNP
rs1326466694 73 dbSNP
rs951874383 74 dbSNP
rs1463128767 77 dbSNP
rs1247826815 78 dbSNP
rs983288710 78 dbSNP
rs1434036390 80 dbSNP
rs907948194 85 dbSNP
rs781027413 88 dbSNP
rs138363621 95 dbSNP
rs897588053 96 dbSNP
rs916589178 100 dbSNP
rs948293958 103 dbSNP
rs1044359295 105 dbSNP
rs1191546483 108 dbSNP
rs377149657 109 dbSNP
rs79281963 110 dbSNP
rs952908371 113 dbSNP
rs1386072121 122 dbSNP
rs1469430976 129 dbSNP
rs935466784 134 dbSNP
rs558127229 135 dbSNP
rs1339605746 148 dbSNP
rs984371953 160 dbSNP
rs1398733044 169 dbSNP
rs1225024118 177 dbSNP
rs1018470464 185 dbSNP
rs1304080903 186 dbSNP
rs1368907184 187 dbSNP
rs1442923752 187 dbSNP
rs1325246518 190 dbSNP
rs891521753 193 dbSNP
rs189274236 194 dbSNP
rs976742311 198 dbSNP
rs1461848128 200 dbSNP
rs1018573226 206 dbSNP
rs546174031 211 dbSNP
rs900174805 215 dbSNP
rs769379525 222 dbSNP
rs562911960 224 dbSNP
rs1316956069 231 dbSNP
rs1362604835 238 dbSNP
rs1437878010 240 dbSNP
rs527646903 240 dbSNP
rs60381343 240 dbSNP
rs915097023 240 dbSNP
rs1252318046 243 dbSNP
rs1193655556 244 dbSNP
rs116423512 247 dbSNP
rs1226273392 248 dbSNP
rs1280726131 250 dbSNP
rs1045031098 253 dbSNP
rs1340877510 255 dbSNP
rs1345701901 257 dbSNP
rs1195933761 262 dbSNP
rs1243065681 268 dbSNP
rs772627874 271 dbSNP
rs1337598253 289 dbSNP
rs1327118800 293 dbSNP
rs542331093 306 dbSNP
rs905091948 307 dbSNP
rs983236879 312 dbSNP
rs369194363 317 dbSNP
rs1014726077 323 dbSNP
rs960757692 329 dbSNP
rs939226746 330 dbSNP
rs1433224467 334 dbSNP
rs992657798 343 dbSNP
rs916701686 349 dbSNP
rs1159652185 351 dbSNP
rs969789784 362 dbSNP
rs562120278 369 dbSNP
rs1179257556 370 dbSNP
rs778502341 380 dbSNP
rs1279592862 382 dbSNP
rs3834572 382 dbSNP
rs925510731 382 dbSNP
rs1224213933 383 dbSNP
rs1168621596 385 dbSNP
rs397787786 391 dbSNP
rs935581488 391 dbSNP
rs1462560357 394 dbSNP
rs1314971859 396 dbSNP
rs1413398138 397 dbSNP
rs1375212848 401 dbSNP
rs1172110923 402 dbSNP
rs1319557976 403 dbSNP
rs763990221 407 dbSNP
rs868348442 414 dbSNP
rs1386520059 415 dbSNP
rs888642924 419 dbSNP
rs1405232942 421 dbSNP
rs1052581577 423 dbSNP
rs912737298 424 dbSNP
rs944404484 425 dbSNP
rs1256460227 426 dbSNP
rs1005659323 434 dbSNP
rs762880148 438 dbSNP
rs1282041164 451 dbSNP
rs1383260144 454 dbSNP
rs1335546758 466 dbSNP
rs1295413454 468 dbSNP
rs1231626690 469 dbSNP
rs900290340 472 dbSNP
rs964278125 472 dbSNP
rs976936496 473 dbSNP
rs996227603 475 dbSNP
rs1048750351 481 dbSNP
rs1318240519 482 dbSNP
rs1292979772 491 dbSNP
rs887669051 501 dbSNP
rs1456303520 505 dbSNP
rs1394501409 519 dbSNP
rs373423952 529 dbSNP
rs527920201 530 dbSNP
rs1459513191 536 dbSNP
rs1412831449 540 dbSNP
rs1186941178 543 dbSNP
rs1476254520 544 dbSNP
rs1014673888 549 dbSNP
rs1240356789 552 dbSNP
rs541315062 561 dbSNP
rs1468978756 567 dbSNP
rs1275079413 577 dbSNP
rs1321984387 580 dbSNP
rs1013457676 581 dbSNP
rs1024120000 584 dbSNP
rs770832417 587 dbSNP
rs115848523 588 dbSNP
rs925291435 593 dbSNP
rs1442195342 595 dbSNP
rs988664170 597 dbSNP
rs1327273658 608 dbSNP
rs915315807 609 dbSNP
rs1348986506 611 dbSNP
rs533447115 612 dbSNP
rs1167892929 613 dbSNP
rs1454619817 617 dbSNP
rs1429392813 619 dbSNP
rs759366155 623 dbSNP
rs1427322324 626 dbSNP
rs939253056 628 dbSNP
rs1233721819 631 dbSNP
rs912852564 641 dbSNP
rs549324302 643 dbSNP
rs1468104613 645 dbSNP
rs944201555 651 dbSNP
rs1039898001 653 dbSNP
rs921665336 659 dbSNP
rs931765387 676 dbSNP
rs1048689511 677 dbSNP
rs1350744077 679 dbSNP
rs887449177 688 dbSNP
rs1004536726 700 dbSNP
rs1438152539 710 dbSNP
rs928974519 711 dbSNP
rs192655793 716 dbSNP
rs1007237816 718 dbSNP
rs1352581275 718 dbSNP
rs753555294 718 dbSNP
rs764280062 719 dbSNP
rs754014223 722 dbSNP
rs1286941730 726 dbSNP
rs1013822294 727 dbSNP
rs1340190430 733 dbSNP
rs1023479688 734 dbSNP
rs1432678431 736 dbSNP
rs762057825 738 dbSNP
rs1382466606 739 dbSNP
rs765298054 743 dbSNP
rs1408737172 766 dbSNP
rs1479757562 770 dbSNP
rs759048337 770 dbSNP
rs547552943 774 dbSNP
rs998429754 784 dbSNP
rs1251319547 785 dbSNP
rs1212106687 788 dbSNP
rs1056111 794 dbSNP
rs559130180 800 dbSNP
rs1486849322 803 dbSNP
rs764731480 804 dbSNP
rs1343113029 808 dbSNP
rs969853544 809 dbSNP
rs528951838 810 dbSNP
rs1311113901 812 dbSNP
rs1029905397 816 dbSNP
rs1284481229 818 dbSNP
rs956948492 824 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ggggguaacgaugUCGGCGGACa 5'
                       | ||||||| 
Target 5' --------aagugAUCCGCCUGc 3'
 		1 - 15
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000338859.4 | 3UTR | AAGUGAUCCGCCUGCCUUGGCCUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
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40 hsa-miR-3937 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT332487 CD81 CD81 molecule 2 2
MIRT441327 NDUFA11 NADH:ubiquinone oxidoreductase subunit A11 2 4
MIRT454032 EIF3CL eukaryotic translation initiation factor 3 subunit C like 2 2
MIRT458086 EIF3C eukaryotic translation initiation factor 3 subunit C 2 2
MIRT460785 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT463150 ZNF385A zinc finger protein 385A 2 4
MIRT467162 SREBF2 sterol regulatory element binding transcription factor 2 2 2
MIRT469618 RAI1 retinoic acid induced 1 2 4
MIRT472258 NFIC nuclear factor I C 2 2
MIRT487587 FAM83H family with sequence similarity 83 member H 2 4
MIRT489302 B4GALNT4 beta-1,4-N-acetyl-galactosaminyltransferase 4 2 4
MIRT489741 GNAI2 G protein subunit alpha i2 2 4
MIRT490038 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT490767 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491750 SEMA3F semaphorin 3F 2 2
MIRT492690 PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2 2
MIRT504843 RRP36 ribosomal RNA processing 36 2 4
MIRT510116 IRAK3 interleukin 1 receptor associated kinase 3 2 8
MIRT525313 FANCA Fanconi anemia complementation group A 2 4
MIRT569801 IGDCC3 immunoglobulin superfamily DCC subclass member 3 2 2
MIRT570224 SLC27A1 solute carrier family 27 member 1 2 2
MIRT629378 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT633104 CBX5 chromobox 5 2 2
MIRT645036 ATAD3C ATPase family, AAA domain containing 3C 2 2
MIRT660973 ABI2 abl interactor 2 2 2
MIRT671225 CLSTN1 calsyntenin 1 2 2
MIRT672046 SMTNL2 smoothelin like 2 2 2
MIRT677314 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT678290 PTRH2 peptidyl-tRNA hydrolase 2 2 2
MIRT693477 ZNF707 zinc finger protein 707 2 2
MIRT693576 PIGR polymeric immunoglobulin receptor 2 2
MIRT696832 PLLP plasmolipin 2 2
MIRT700149 RNF115 ring finger protein 115 2 2
MIRT703760 FAM118A family with sequence similarity 118 member A 2 2
MIRT705798 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT709105 SEPT4 septin 4 2 2
MIRT710235 ARMCX6 armadillo repeat containing, X-linked 6 2 2
MIRT711422 EPHA4 EPH receptor A4 2 2
MIRT712529 CYTH2 cytohesin 2 2 2
MIRT714081 ZNF532 zinc finger protein 532 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3937 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3937 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3937 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3937 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3937 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3937 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-3937 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-3937 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-3937 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-3937 Taxane/Cisplatin/Fluorouracil sensitive High Hypopharyngeal Squamous Cell Carcinoma tissue
hsa-miR-3937 Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer cell line (A2780)
hsa-mir-3937 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-3937 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-3937 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-3937 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-3937 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-3937 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-3937 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-3937 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-3937 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3937 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-3937 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-3937 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-3937 Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-3937 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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