miRTarBase - #MIRT673006


—
pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TAF1   
Synonyms BA2R, CCG1, CCGS, DYT3, DYT3/TAF1, KAT4, MRXS33, N-TAF1, NSCL2, OF, P250, TAF(II)250, TAF2A, TAFII-250, TAFII250, XDP
Description TATA-box binding protein associated factor 1
Transcript NM_004606   
Other Transcripts NM_138923   
Expression
Putative miRNA Targets on TAF1
3'UTR of TAF1
(miRNA target sites are highlighted)		 
>TAF1|NM_004606|3'UTR
   1 GGCTTCCTTTGGGCCTCCTTGGTCAGCCTTCCCTGTTCTCCAGCCTAGGTGGTTCACCTTTCCCCAATTTGTTCATATTT
  81 GTACAGTATCTGATCCTGAAATCATGAAATTAACTAACACCTTAGCCTTTTTAAAAGTAGTAAGTAAATGATAATAAATC
 161 ACCTCTCCTAATCTTCCTGGGGCAATGTCACCCTTTGATTTAAAACAAAGCAACCCCCTTTCCCCTACCACTACGGAAAA
 241 GAGCAAGCTCATTTTTCCGTGTCCTCCTTTATTTAACTCCATTTATTGCTTTTGGTATAATTTTTCCCTGGGGAAGGAGG
 321 GGAAATTATGAAAGAACTAGTAACTTTATGTCCTCTTGATGTATTAGGAAATTTCCGGCCAGGCGTGGTGGCTCACACCT
 401 GTAATCTCAGCACTCTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCAGAAGTTCGAGACCAGCTTGGCCAACATGGCG
 481 AAACCGCATCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCGTATGCCTGTTAATCCTAGCTACTCGGGAGGCT
 561 GAGGCAGGAGAATTACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGTGGAGGTCACGCCACTGCACTCCAGCCTGGGCGA
 641 AAGAGTGAGATTCAGTCTCAAAAAAAAAAAAATTTCCAAGCATGGTATCATCTCACTTTTCTAATTTACAGGCTGGAGCA
 721 GATGAGAGCCCTCCTGCTGGGACAGAGAATTGGGTTCTAGTGGACTCTGTGCTACACTTAAACCTGTGAGACAAACCGCC
 801 CATTATTTTATTATTTAATTATGCAATGCCTAGTTCCTAAATGGATTGGAGGCAAATTACCGTAAATTTTGAAACAGCCT
 881 ATATGTCAGAAATGATAATGTTGCCACCTAAATGTTTTCTGTCCCCCCCACCCTCCCCAGGGGAAATGGTAGGAAAATGG
 961 TAAGTTTCTTAGGGCAAAGACTGTGTCTTCTGTTTCTTTTCATGCTTAGGATATGGTTCTGTGCATAGTAGGTACTCAGT
1041 AAATGTTCCTAGAATCATAAAATCCTCAACAGATATGTTACTGAGCATCTGCTTTTCATGATAAGCACTCTATCAGATCC
1121 TTGGGATGCAAAGGTAAATAAGACAAATCCCTTTTACCCAAAGAGCTCACCATCAAGTTGGGGGAGGGAAAGTGGAATTC
1201 AAAACATGTTAATAAATCATCATAGTACTGTGAGATAAGTGCAATTAAGAAGCTAGTTATAAAGTATAGGGGAAATAGAG
1281 GAGTAATCATGTCTGAAAAGTCAGGAAAGTCTTCCTAGAGGTAATTTTTAAGCTGATTGTTTTAGAATTAGTAGAAGCTT
1361 GCCAGATGGAAAAGTCCAGGCAAAGTGTAACATGAATGGGAAAGGCCACAGTCTAGAAATGGCAGAGTGTGTTCCTAGTT
1441 TGTTTGTTTGTTTGTTTGTACCTGCCTTGTTCCAGGAAGGATTTAATGTGGTTTATATTCCAGTCCTTTAATGCTGGAAG
1521 GGCTGAGATGAGACTGAAAGATGGGCAGGAAGTATATCATCACAAGCTTTGTGTTTGATGTTAATGTGTATGATTTTTAT
1601 ATTATGGGAAATAAGCTCTTAGAGGAGTGATATAATCAGGTTTGTGTTTTAGAAATCTGTGTAATGAATGAATGAAGAAA
1681 GAAATTGAAGAATCATGTAACATATGTGATCGCATTTTTGTAAAAGAACCATGTGTGTTTATATGTGTTTATATATATAC
1761 TTGTGTATGCAAAGGTAAAAGTCTGAAAGGATATATGCTAACTGTTCACAATGATAACCCCCCAGGAATGGGATTGGAGG
1841 GGAGGGGGCTTCTGTGTTTGTTATGTATGCTGGGTGGGATATTGTGCTTTTATTTCTATATTGTTTGAATTTTTTTACAG
1921 TATGTATTATTTTTGTAATAAAAATTTTAAAAAATTCCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acgGUCGGAGCGGGUcg 5'
             ||  | ||||||  
Target 5' agaCAAAC-CGCCCAtt 3'
 789 - 804 121.00 -10.80
2 
miRNA  3' acGGUCGGAGCGGGUCg 5'
            ||| |||| ||||| 
Target 5' ccCCACCCTC-CCCAGg 3'
 926 - 941 115.00 -19.20
3 
miRNA  3' acgguCGGAGCGGGUCg 5'
               ||  :|||:|| 
Target 5' attatGCAATGCCTAGt 3'
 818 - 834 112.00 -12.60
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1426766890 13 dbSNP
rs1294739734 27 dbSNP
rs944856523 29 dbSNP
rs769437084 31 dbSNP
rs1326882414 33 dbSNP
rs867991880 34 dbSNP
rs992007302 36 dbSNP
rs1270283560 46 dbSNP
rs1205114355 65 dbSNP
rs1479915579 68 dbSNP
rs917801386 71 dbSNP
rs976676577 75 dbSNP
rs922122284 76 dbSNP
rs1205580115 79 dbSNP
rs1350403515 86 dbSNP
rs1281593786 101 dbSNP
rs1237598658 111 dbSNP
rs1346270719 112 dbSNP
rs768879823 113 dbSNP
rs776575445 125 dbSNP
rs146478889 133 dbSNP
rs1047492196 141 dbSNP
rs1043870798 155 dbSNP
rs903845591 161 dbSNP
rs935336490 171 dbSNP
rs1403508575 177 dbSNP
rs1178106385 179 dbSNP
rs908568398 183 dbSNP
rs770964816 186 dbSNP
rs1209421505 189 dbSNP
rs1178972285 192 dbSNP
rs941422887 194 dbSNP
rs1253279205 220 dbSNP
rs1178195368 225 dbSNP
rs891725458 228 dbSNP
rs1483113752 234 dbSNP
rs1014060151 235 dbSNP
rs1261539898 236 dbSNP
rs1024079752 244 dbSNP
rs905728599 251 dbSNP
rs1267591975 257 dbSNP
rs899921768 259 dbSNP
rs997401996 260 dbSNP
rs1307592697 265 dbSNP
rs1395281765 278 dbSNP
rs1001237534 280 dbSNP
rs1027396209 291 dbSNP
rs1338399813 294 dbSNP
rs1452931014 296 dbSNP
rs1387368896 306 dbSNP
rs1156370827 319 dbSNP
rs769848536 323 dbSNP
rs1366102050 331 dbSNP
rs1051286916 351 dbSNP
rs1444515804 352 dbSNP
rs1241702361 358 dbSNP
rs891361043 377 dbSNP
rs193004892 378 dbSNP
rs1020577631 385 dbSNP
rs776757007 386 dbSNP
rs1352892932 395 dbSNP
rs967724167 397 dbSNP
rs1000493672 412 dbSNP
rs1357117849 414 dbSNP
rs1251254485 419 dbSNP
rs763417621 425 dbSNP
rs1364079516 426 dbSNP
rs1315758812 428 dbSNP
rs1383451538 430 dbSNP
rs983526782 431 dbSNP
rs769998735 433 dbSNP
rs1033347741 435 dbSNP
rs1189588099 442 dbSNP
rs1383923466 446 dbSNP
rs1165931639 451 dbSNP
rs959132426 457 dbSNP
rs1372763668 473 dbSNP
rs1015155344 480 dbSNP
rs1448906536 481 dbSNP
rs1262532027 486 dbSNP
rs766702097 487 dbSNP
rs774727720 488 dbSNP
rs760277145 494 dbSNP
rs1393028954 495 dbSNP
rs1158328797 512 dbSNP
rs775575079 515 dbSNP
rs1341155813 523 dbSNP
rs922089500 528 dbSNP
rs761625190 529 dbSNP
rs1326586235 531 dbSNP
rs950673685 536 dbSNP
rs1402542612 543 dbSNP
rs983426944 551 dbSNP
rs767268984 553 dbSNP
rs1305458356 554 dbSNP
rs1425806205 559 dbSNP
rs763735699 565 dbSNP
rs1166456360 576 dbSNP
rs1476514761 577 dbSNP
rs1373853562 583 dbSNP
rs925360419 585 dbSNP
rs1368215298 586 dbSNP
rs1271006326 592 dbSNP
rs1223170286 596 dbSNP
rs1437108682 597 dbSNP
rs1270630974 599 dbSNP
rs753414288 602 dbSNP
rs1197333863 609 dbSNP
rs1339734507 617 dbSNP
rs1390132988 618 dbSNP
rs1221198055 625 dbSNP
rs756886283 639 dbSNP
rs941303258 646 dbSNP
rs1335618424 657 dbSNP
rs1175932073 660 dbSNP
rs1327349084 660 dbSNP
rs1411987644 660 dbSNP
rs879103327 660 dbSNP
rs935322425 668 dbSNP
rs1052877305 674 dbSNP
rs1469625924 678 dbSNP
rs1231094459 679 dbSNP
rs1183788985 691 dbSNP
rs760764839 706 dbSNP
rs917954148 717 dbSNP
rs764838702 724 dbSNP
rs1201414182 731 dbSNP
rs750428171 738 dbSNP
rs1045664300 742 dbSNP
rs1222700667 754 dbSNP
rs1420090507 758 dbSNP
rs1350661073 760 dbSNP
rs1278271999 763 dbSNP
rs1444861326 764 dbSNP
rs1378144947 766 dbSNP
rs1336427324 768 dbSNP
rs905697163 777 dbSNP
rs1344569591 784 dbSNP
rs1001332352 797 dbSNP
rs1229478270 799 dbSNP
rs1400174433 801 dbSNP
rs1405755956 803 dbSNP
rs1160260070 819 dbSNP
rs1273972957 827 dbSNP
rs1470443919 843 dbSNP
rs1042582146 857 dbSNP
rs1181455086 857 dbSNP
rs1479716855 862 dbSNP
rs1048761660 863 dbSNP
rs887544022 879 dbSNP
rs113203261 882 dbSNP
rs1014983734 886 dbSNP
rs1314578049 894 dbSNP
rs1441570124 895 dbSNP
rs965777495 898 dbSNP
rs779739889 906 dbSNP
rs746747548 907 dbSNP
rs1185139205 914 dbSNP
rs1391839716 922 dbSNP
rs1000462735 923 dbSNP
rs755165000 923 dbSNP
rs1449672932 925 dbSNP
rs1244222880 928 dbSNP
rs781449142 930 dbSNP
rs1167613877 931 dbSNP
rs1387737053 935 dbSNP
rs1467153593 940 dbSNP
rs1174767693 941 dbSNP
rs748362504 943 dbSNP
rs1403541514 945 dbSNP
rs1396022655 948 dbSNP
rs1335118110 951 dbSNP
rs1367847868 959 dbSNP
rs1446206525 960 dbSNP
rs1436038112 961 dbSNP
rs1297177029 962 dbSNP
rs1185601975 969 dbSNP
rs1484658404 978 dbSNP
rs769899891 979 dbSNP
rs1305785453 980 dbSNP
rs1235522193 982 dbSNP
rs1243357422 982 dbSNP
rs1215797196 991 dbSNP
rs1488938659 992 dbSNP
rs1291664521 996 dbSNP
rs183947229 997 dbSNP
rs1256735579 1000 dbSNP
rs997758684 1004 dbSNP
rs1214219479 1025 dbSNP
rs1360053274 1029 dbSNP
rs369241087 1047 dbSNP
rs1380775603 1053 dbSNP
rs773251876 1057 dbSNP
rs1201742887 1060 dbSNP
rs1400674561 1062 dbSNP
rs1029255389 1065 dbSNP
rs953485123 1070 dbSNP
rs1426424603 1073 dbSNP
rs1237489666 1077 dbSNP
rs1025226079 1082 dbSNP
rs753342770 1092 dbSNP
rs1421192476 1093 dbSNP
rs1245830358 1097 dbSNP
rs1434329053 1102 dbSNP
rs1198946347 1104 dbSNP
rs983693315 1113 dbSNP
rs1266106614 1114 dbSNP
rs925361832 1126 dbSNP
rs1376626638 1132 dbSNP
rs1465953873 1134 dbSNP
rs1490967599 1140 dbSNP
rs1266410366 1159 dbSNP
rs1204264825 1162 dbSNP
rs909106278 1171 dbSNP
rs1275350997 1177 dbSNP
rs963305363 1178 dbSNP
rs754452765 1182 dbSNP
rs1281396509 1216 dbSNP
rs1406707618 1217 dbSNP
rs974057297 1233 dbSNP
rs1297456594 1235 dbSNP
rs956992918 1245 dbSNP
rs749780824 1246 dbSNP
rs1391229816 1257 dbSNP
rs1170991455 1258 dbSNP
rs988267200 1260 dbSNP
rs764903368 1261 dbSNP
rs1458112407 1272 dbSNP
rs932726756 1294 dbSNP
rs917909251 1306 dbSNP
rs986940415 1308 dbSNP
rs1481743776 1312 dbSNP
rs1268652599 1321 dbSNP
rs771427701 1324 dbSNP
rs138242643 1343 dbSNP
rs1360132734 1349 dbSNP
rs758767930 1352 dbSNP
rs1199527351 1369 dbSNP
rs1323023283 1375 dbSNP
rs1261339825 1377 dbSNP
rs759887633 1401 dbSNP
rs1225420857 1407 dbSNP
rs778149583 1416 dbSNP
rs1306167810 1425 dbSNP
rs1389569032 1427 dbSNP
rs1375292149 1429 dbSNP
rs927217659 1430 dbSNP
rs1042549717 1438 dbSNP
rs1178042106 1438 dbSNP
rs1302043428 1451 dbSNP
rs1466082792 1461 dbSNP
rs187485993 1462 dbSNP
rs757816917 1477 dbSNP
rs10521350 1490 dbSNP
rs1005034277 1504 dbSNP
rs1329529571 1506 dbSNP
rs1179575728 1510 dbSNP
rs1461088937 1521 dbSNP
rs1207881724 1540 dbSNP
rs1205698147 1548 dbSNP
rs777544967 1553 dbSNP
rs761529826 1556 dbSNP
rs191990084 1557 dbSNP
rs1236814176 1560 dbSNP
rs1036145931 1568 dbSNP
rs745877533 1572 dbSNP
rs1244959537 1573 dbSNP
rs1489249228 1581 dbSNP
rs143254113 1591 dbSNP
rs1029224374 1604 dbSNP
rs1396209510 1605 dbSNP
rs1383646869 1607 dbSNP
rs1286550846 1618 dbSNP
rs1452262340 1623 dbSNP
rs1382693053 1626 dbSNP
rs1159684337 1629 dbSNP
rs1444364628 1636 dbSNP
rs1479182989 1641 dbSNP
rs1197827545 1663 dbSNP
rs1414849280 1677 dbSNP
rs1189909842 1682 dbSNP
rs1473245499 1686 dbSNP
rs1261134397 1687 dbSNP
rs1203463409 1688 dbSNP
rs184771503 1691 dbSNP
rs1024687502 1695 dbSNP
rs1221516568 1698 dbSNP
rs1001145106 1700 dbSNP
rs766277385 1702 dbSNP
rs1294369902 1704 dbSNP
rs751435870 1706 dbSNP
rs1325417236 1707 dbSNP
rs377057245 1710 dbSNP
rs1390039577 1712 dbSNP
rs57375570 1713 dbSNP
rs1290062229 1724 dbSNP
rs1351028008 1726 dbSNP
rs1227769080 1732 dbSNP
rs776513189 1740 dbSNP
rs1364118998 1744 dbSNP
rs956933936 1752 dbSNP
rs1165301773 1763 dbSNP
rs1304562213 1770 dbSNP
rs1016134550 1773 dbSNP
rs1323318196 1776 dbSNP
rs1372707702 1801 dbSNP
rs1191187222 1805 dbSNP
rs1221784810 1810 dbSNP
rs1478827358 1810 dbSNP
rs1198626621 1812 dbSNP
rs1264507352 1818 dbSNP
rs988624847 1846 dbSNP
rs918016979 1864 dbSNP
rs974699319 1868 dbSNP
rs1210209442 1879 dbSNP
rs1338409906 1884 dbSNP
rs775762471 1886 dbSNP
rs1251983355 1887 dbSNP
rs1483656940 1891 dbSNP
rs1177174711 1902 dbSNP
rs1229110657 1910 dbSNP
rs1028736407 1918 dbSNP
rs1282026486 1925 dbSNP
rs759576883 1925 dbSNP
rs954039319 1927 dbSNP
rs987205980 1929 dbSNP
rs749516979 1931 dbSNP
rs912622968 1937 dbSNP
rs945463817 1945 dbSNP
rs190486499 1950 dbSNP
rs1175710472 1953 dbSNP
rs927186721 1956 dbSNP
rs1248370956 1958 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acggUCGG-AGCGggucg 5'
              ||||  |||     
Target 5' cgugAGCCACCGCg---- 3'
 		23 - 36
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000373790.4 | 3UTR | UUACAGGCGUGAGCCACCGCGCCCAGCCAAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084045
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep3
Location of target site ENST00000373790.4 | 3UTR | CUCAAAGUGCUGGGAUUACAGGCGUGAGCCACCGCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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