pre-miRNA Information
pre-miRNA hsa-mir-3622a   
Genomic Coordinates chr8: 27701677 - 27701759
Description Homo sapiens miR-3622a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3622a-5p
Sequence 14| CAGGCACGGGAGCUCAGGUGAG |35
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 8 + 27701691 29233923 MiREDiBase
A-to-I 6 8 + 27701695 29233923 MiREDiBase
A-to-I 16 8 + 27701705 28550310, 29233923 MiREDiBase
A-to-I 21 8 + 27701710 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs551845360 1 dbSNP
rs946438979 3 dbSNP
rs1044808718 7 dbSNP
rs66683138 8 dbSNP
rs1157333896 10 dbSNP
rs1439657384 12 dbSNP
rs530939348 17 dbSNP
rs1232922758 20 dbSNP
rs1448152954 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol APAF1   
Synonyms APAF-1, CED4
Description apoptotic peptidase activating factor 1
Transcript NM_181869   
Other Transcripts NM_013229 , NM_181861 , NM_181868 , NM_001160   
Expression
Putative miRNA Targets on APAF1
3'UTR of APAF1
(miRNA target sites are highlighted)
>APAF1|NM_181869|3'UTR
   1 GAAAATACACGTGTCCCCTGACTTCAAAACATATGTGACTGTGGATAATCTTGGTATTTTATATATTTTACAGACTTTAG
  81 AATAAAATAGTTAAGCATTAATGTAGTTGAACTTTTTAAATTTTTGAATTGGAAAAAAATTCTAATGAAACCCTGATATC
 161 AACTTTTTATAAAGCTCTTAATTGTTGTGCAGTATTGCATTCATTACAAAAGTGTTTGTGGTTGGATGAATAATATTAAT
 241 GTAGCTTTTTCCCAAATGAACATACCTTTAATCTTGTTTTTCATGATCATCATTAACAGTTTGTCCTTAGGATGCAAATG
 321 AAAATGTGAATACATACCTTGTTGTACTGTTGGTAAAATTCTGTCTTGATGCATTCAAAATGGTTGACATAATTAATGAG
 401 AAGAATTTGGAAGAAATTGGTATTTTAATACTGTCTGTATTTATTACTGTTATGCAGGCTGTGCCTCAGGGTAGCAGTGG
 481 CCTGCTTTTTGAACCACACTTACCCCAAGGGGGTTTTGTTCTCCTAAATACAATCTTAGAGGTTTTTTGCACTCTTTAAA
 561 TTTGCTTTAAAAATATTGTGTCTGTGTGCATAGTCTGCAGCATTTCCTTTAATTGACTCAATAAGTGAGTCTTGGATTTA
 641 GCAGGCCCCCCCACCTTTTTTTTTTGTTTTTGGAGACAGAGTCTTGCTTTGTTGCCAGGCTGGAGTGCAGTGGCGCGATC
 721 TCGGCTCACCACAATCGCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGT
 801 GCGCACATGCCAGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCGGGATGGTCTCGATCTCTTG
 881 ACCTCATGATCTACCCGCCTTGGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGTGCCTGGCCAGGCCCCTTCT
 961 CTTTTAATGGAGACAGGGTCTTGCACTATCACCCAGGCTGGAGTGCAGTGGCATAATCATACCTCATTGCAGCCTCAGAC
1041 TCCTGGGTTCAAGCAATCCTCCTGCCTCAGCCTCCCAAGTAGCTGAGACTACAGGCACGAGCCACCACACCCAGCTAATT
1121 TTTAAGTTTTCTTGTAGAGACAGGGTCTCACTATGTTGTCTAGGCTGGTCTTGAACTCTTGGCCTCAAGTAATCCTCCTG
1201 CCTCAGCCTCCCAAAGTGTTGGGATTGCAGATATGAGCCACTGGCCTGGCCTTCAGCAGTTCTTTTTGTGAAGTAAAACT
1281 TGTATGTTGGAAAGAGTAGATTTTATTGGTCTACCCTTTTCTCACTGTAGCTGCTGGCAGCCCTGTGCCATATCTGGACT
1361 CTAGTTGTCAGTATCTGAGTTGGACACTATTCCTGCTCCCTCTTGTTTCTTACATATCAGACTTCTTACTTGAATGAAAC
1441 CTGATCTTTCCTAATCCTCACTTTTTTCTTTTTTAAAAAGCAGTTTCTCCACTGCTAAATGTTAGTCATTGAGGTGGGGC
1521 CAATTTTAATCATAAGCCTTAATAAGATTTTTCTAAGAAATGTGAAATAGAACAATTTTCATCTAATTCCATTTACTTTT
1601 AGATGAATGGCATTGTGAATGCCATTCTTTTAATGAATTTCAAGAGAATTCTCTGGTTTTCTGTGTAATTCCAGATGAGT
1681 CACTGTAACTCTAGAAGATTAACCTTCCAGCCAACCTATTTTCCTTTCCCTTGTCTCTCTCATCCTCTTTTCCTTCCTTC
1761 TTTCCTTTCTCTTCTTTTATCTCCAAGGTTAATCAGGAAAAATAGCTTTTGACAGGGGAAAAAACTCAATAACTAGCTAT
1841 TTTTGACCTCCTGATCAGGAACTTTAGTTGAAGCGTAAATCTAAAGAAACATTTTCTCTGAAATATATTATTAAGGGCAA
1921 TGGAGATAAATTAATAGTAGATGTGGTTCCCAGAAAATATAATCAAAATTCAAAGATTTTTTTTGTTTCTGTAACTGGAA
2001 CTAAATCAAATGATTACTAGTGTTAATAGTAGATAACTTGTTTTTATTGTTGGTGCATATTAGTATAACTGTGGGGTAGG
2081 TCGGGGAGAGGGTAAGGGAATAGATCACTCAGATGTATTTTAGATAAGCTATTTAGCCTTTGATGGAATCATAAATACAG
2161 TGAATACAATCCTTTGCATTGTTAAGGAGGTTTTTTGTTTTTAAATGGTGGGTCAAGGAGCTAGTTTACAGGCTTACTGT
2241 GATTTAAGCAAATGTGAAAAGTGAAACCTTAATTTTATCAAAAGAAATTTCTGTAAATGGTATGTCTCCTTAGAATACCC
2321 AAATCATAATTTTATTTGTACACACTGTTAGGGGCTCATCTCATGTAGGCAGAGTATAAAGTATTACCTTTTGGAATTAA
2401 AAGCCACTGACTGTTATAAAGTATAACAACACACATCAGGTTTTAAAAAGCCTTGAATGGCCCTTGTCTTAAAAAGAAAT
2481 TAGGAGCCAGGTGCGGTGGCACGTGCCTGTAATCCCAGCTCCTTGGGAGGCTAAGACAGGAGGATTCCTTGAGCCCTGGA
2561 GTTTGAGTCCAGCCTGGGTGACATAGCAAGACCCTGTCTTAAAAGAAAAATGGGAAGAAAGACAAGGTAACATGAAGAAA
2641 GAAGAGATACCTAGTATGATGGAGCTGCAAATTTCATGGCAGTTCATGCAGTCGGTCAAGAGGAGGATTTTGTTTTGTAG
2721 TTTGCAGATGAGCATTTCTAAAGCATTTTCCCTTGCTGTATTTTTTTGTATTATAAATTACATTGGACTTCATATATATA
2801 ATTTTTTTTTACATTATATGTCTCTTGTATGTTTTGAAACTCTTGTATTTATGATATAGCTTATATGATTTTTTTGCCTT
2881 GGTATACATTTTAAAATATGAATTTAAAAAATTTTTGTAAAAATAAAATTCACAAAATTGTTTTGAAAAACAAAAAAAAA
2961 AAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gagUGGACUCGAGGGCACGGAc 5'
             :| |||||  |||||||| 
Target 5' cagGCGTGAGCCACCGTGCCTg 3'
925 - 946 167.00 -30.00
2
miRNA  3' gaGUGGACUCGA--GGGCACGGAc 5'
            ||  || | |  | ||||||| 
Target 5' gcCAGGTGCGGTGGCACGTGCCTg 3'
2486 - 2509 150.00 -20.60
3
miRNA  3' gaguggacucgagGGCACGGAc 5'
                       |:|||||| 
Target 5' actgttatgcaggCTGTGCCTc 3'
446 - 467 129.00 -16.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM1365091 12 COSMIC
COSM5443028 16 COSMIC
COSM236690 18 COSMIC
COSM5890669 24 COSMIC
COSM7633833 51 COSMIC
COSM9275239 68 COSMIC
COSM5558470 69 COSMIC
COSM4789083 80 COSMIC
COSN31604422 120 COSMIC
COSN18736275 140 COSMIC
COSN31580311 159 COSMIC
COSN19037804 239 COSMIC
COSN31882044 455 COSMIC
COSN24216807 654 COSMIC
COSN29164546 1075 COSMIC
COSN20110001 1440 COSMIC
COSN21625017 1593 COSMIC
COSN6538084 1687 COSMIC
COSN20785323 1738 COSMIC
COSN25773491 1876 COSMIC
COSN28774781 2164 COSMIC
COSN26646123 2198 COSMIC
COSN30161476 2232 COSMIC
COSN16128806 2258 COSMIC
COSN5872645 2380 COSMIC
COSN31567467 2382 COSMIC
COSN25926631 2516 COSMIC
COSN30053889 2728 COSMIC
COSN29472808 2768 COSMIC
COSN31578320 2937 COSMIC
rs116928965 2614 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs752622248 3 dbSNP
rs756138161 6 dbSNP
rs1397034513 7 dbSNP
rs777810915 9 dbSNP
rs1158662598 11 dbSNP
rs201029707 12 dbSNP
rs778485671 13 dbSNP
rs745529226 16 dbSNP
rs369751053 17 dbSNP
rs1440143134 18 dbSNP
rs1323792662 19 dbSNP
rs142230441 21 dbSNP
rs902945001 25 dbSNP
rs746482334 27 dbSNP
rs769157410 28 dbSNP
rs1331776919 34 dbSNP
rs372861046 35 dbSNP
rs1397949057 38 dbSNP
rs1229819694 41 dbSNP
rs1336372390 45 dbSNP
rs762226148 46 dbSNP
rs1373951430 53 dbSNP
rs1269220874 55 dbSNP
rs770194972 56 dbSNP
rs1433218417 61 dbSNP
rs375449857 62 dbSNP
rs763208735 63 dbSNP
rs1488857310 71 dbSNP
rs1176645020 72 dbSNP
rs1189146612 73 dbSNP
rs1248721343 77 dbSNP
rs369724536 79 dbSNP
rs1160150643 81 dbSNP
rs751718621 83 dbSNP
rs118102803 89 dbSNP
rs375966404 90 dbSNP
rs753812248 92 dbSNP
rs968617287 104 dbSNP
rs1225828520 105 dbSNP
rs1297146535 110 dbSNP
rs1256664016 112 dbSNP
rs1370515842 127 dbSNP
rs1205685152 132 dbSNP
rs1016586071 136 dbSNP
rs1288588116 137 dbSNP
rs979573876 138 dbSNP
rs963280514 155 dbSNP
rs993292310 160 dbSNP
rs1373347578 162 dbSNP
rs1244582939 172 dbSNP
rs571007553 178 dbSNP
rs1445703144 189 dbSNP
rs1374608282 208 dbSNP
rs1033710763 210 dbSNP
rs1466467003 214 dbSNP
rs1361110314 241 dbSNP
rs1225245897 242 dbSNP
rs1173336133 246 dbSNP
rs1290988539 267 dbSNP
rs758919119 277 dbSNP
rs951484146 284 dbSNP
rs1159652693 286 dbSNP
rs147973432 292 dbSNP
rs1202967772 300 dbSNP
rs1035723923 331 dbSNP
rs1440475633 334 dbSNP
rs1184165863 339 dbSNP
rs1483859332 343 dbSNP
rs1327741762 360 dbSNP
rs1237047136 367 dbSNP
rs543214134 372 dbSNP
rs17227606 373 dbSNP
rs1239650003 375 dbSNP
rs1446615006 384 dbSNP
rs574891254 390 dbSNP
rs1396601173 391 dbSNP
rs541930021 398 dbSNP
rs1378264456 399 dbSNP
rs947586974 400 dbSNP
rs977602094 403 dbSNP
rs1360804864 418 dbSNP
rs376693352 421 dbSNP
rs1417462028 437 dbSNP
rs933077694 440 dbSNP
rs1408149606 453 dbSNP
rs370287396 454 dbSNP
rs575996323 458 dbSNP
rs1167349526 459 dbSNP
rs1355032916 460 dbSNP
rs1424910450 468 dbSNP
rs888820689 471 dbSNP
rs943026290 474 dbSNP
rs930461859 478 dbSNP
rs752707499 482 dbSNP
rs1384586349 486 dbSNP
rs1263967317 493 dbSNP
rs1216236559 499 dbSNP
rs899094944 510 dbSNP
rs115805629 512 dbSNP
rs910282366 513 dbSNP
rs546217051 516 dbSNP
rs906363434 524 dbSNP
rs1216226948 536 dbSNP
rs187945549 552 dbSNP
rs1040026640 558 dbSNP
rs902097254 560 dbSNP
rs1397827185 565 dbSNP
rs1366982661 566 dbSNP
rs1295673315 577 dbSNP
rs958780733 578 dbSNP
rs1349626253 579 dbSNP
rs1275775833 584 dbSNP
rs748863900 585 dbSNP
rs991908570 587 dbSNP
rs1192951413 591 dbSNP
rs1021600743 594 dbSNP
rs1458591067 603 dbSNP
rs768516013 621 dbSNP
rs1210246325 624 dbSNP
rs1488058589 632 dbSNP
rs968974385 633 dbSNP
rs1043023946 635 dbSNP
rs1200517721 637 dbSNP
rs1318513531 642 dbSNP
rs1277028151 646 dbSNP
rs977649550 646 dbSNP
rs1332489814 648 dbSNP
rs1301589441 650 dbSNP
rs116884285 652 dbSNP
rs368133650 653 dbSNP
rs1188433734 654 dbSNP
rs1401586096 655 dbSNP
rs1281557330 656 dbSNP
rs1464096787 656 dbSNP
rs933466736 666 dbSNP
rs1199913684 667 dbSNP
rs1432811777 667 dbSNP
rs987276468 668 dbSNP
rs1180208916 671 dbSNP
rs1474342274 673 dbSNP
rs1169399786 677 dbSNP
rs562116231 678 dbSNP
rs780615265 678 dbSNP
rs1196639885 685 dbSNP
rs1033743464 692 dbSNP
rs1256056724 693 dbSNP
rs1469184103 707 dbSNP
rs1037785643 715 dbSNP
rs1173644067 716 dbSNP
rs772060174 717 dbSNP
rs1013543249 718 dbSNP
rs1317282671 719 dbSNP
rs372020077 723 dbSNP
rs1429125009 737 dbSNP
rs929254223 738 dbSNP
rs961669332 739 dbSNP
rs1319250483 741 dbSNP
rs111382335 742 dbSNP
rs1160261786 746 dbSNP
rs547213421 748 dbSNP
rs1440121600 757 dbSNP
rs192421145 764 dbSNP
rs539090638 767 dbSNP
rs1176760120 769 dbSNP
rs550912589 779 dbSNP
rs185285999 780 dbSNP
rs1201103693 789 dbSNP
rs1342464674 795 dbSNP
rs1261348442 797 dbSNP
rs1445470991 798 dbSNP
rs1195085681 799 dbSNP
rs1263551705 801 dbSNP
rs773119241 803 dbSNP
rs1003788569 804 dbSNP
rs1197260661 807 dbSNP
rs1431348013 808 dbSNP
rs1466143622 810 dbSNP
rs1354932127 814 dbSNP
rs536911775 815 dbSNP
rs1033482536 825 dbSNP
rs555558578 831 dbSNP
rs1342720628 839 dbSNP
rs573780976 841 dbSNP
rs760792555 842 dbSNP
rs12307986 843 dbSNP
rs1300333818 845 dbSNP
rs1012976563 848 dbSNP
rs554013473 851 dbSNP
rs1379525699 853 dbSNP
rs1156538685 858 dbSNP
rs866861020 861 dbSNP
rs1368933687 862 dbSNP
rs968695342 864 dbSNP
rs187456676 873 dbSNP
rs1264680159 893 dbSNP
rs922964327 897 dbSNP
rs541603444 898 dbSNP
rs1031927346 901 dbSNP
rs1234114816 907 dbSNP
rs4450213 917 dbSNP
rs1359110794 930 dbSNP
rs1260167962 940 dbSNP
rs1042667061 941 dbSNP
rs766414508 945 dbSNP
rs546229225 955 dbSNP
rs954945703 958 dbSNP
rs375602833 972 dbSNP
rs188204280 989 dbSNP
rs140030216 994 dbSNP
rs964836290 995 dbSNP
rs1055181303 999 dbSNP
rs1315985030 1000 dbSNP
rs1406837862 1002 dbSNP
rs747092806 1004 dbSNP
rs895316251 1019 dbSNP
rs1162641420 1020 dbSNP
rs1219939279 1026 dbSNP
rs543790149 1029 dbSNP
rs1013659413 1034 dbSNP
rs1271028490 1040 dbSNP
rs1193676043 1057 dbSNP
rs562393330 1059 dbSNP
rs192992501 1067 dbSNP
rs1214135901 1069 dbSNP
rs1180512966 1075 dbSNP
rs1291015465 1085 dbSNP
rs1131019 1092 dbSNP
rs961426364 1096 dbSNP
rs143208155 1099 dbSNP
rs1026245399 1100 dbSNP
rs776940896 1111 dbSNP
rs952025064 1135 dbSNP
rs984622581 1137 dbSNP
rs1252331306 1147 dbSNP
rs1047344827 1153 dbSNP
rs1470964302 1154 dbSNP
rs1452443848 1159 dbSNP
rs1331526129 1171 dbSNP
rs12829605 1173 dbSNP
rs532822025 1180 dbSNP
rs975856549 1189 dbSNP
rs922994856 1193 dbSNP
rs1301651877 1197 dbSNP
rs184748337 1205 dbSNP
rs1387817272 1206 dbSNP
rs865866330 1215 dbSNP
rs1464616664 1217 dbSNP
rs1306403221 1222 dbSNP
rs894963528 1231 dbSNP
rs1247659577 1236 dbSNP
rs1198526750 1237 dbSNP
rs188259081 1258 dbSNP
rs1043157215 1262 dbSNP
rs925565865 1263 dbSNP
rs1317425620 1266 dbSNP
rs180779783 1271 dbSNP
rs1310318800 1276 dbSNP
rs1221222615 1280 dbSNP
rs1358972723 1283 dbSNP
rs1031644756 1291 dbSNP
rs1055297552 1292 dbSNP
rs549041592 1294 dbSNP
rs1220007150 1295 dbSNP
rs1438382589 1298 dbSNP
rs1293627963 1299 dbSNP
rs1488770895 1311 dbSNP
rs895348769 1315 dbSNP
rs955143409 1316 dbSNP
rs567542438 1317 dbSNP
rs531488001 1325 dbSNP
rs553163136 1326 dbSNP
rs964898658 1332 dbSNP
rs572588413 1335 dbSNP
rs1384275970 1348 dbSNP
rs973165353 1351 dbSNP
rs920346642 1362 dbSNP
rs758831215 1379 dbSNP
rs1442339737 1381 dbSNP
rs1179881108 1383 dbSNP
rs950435537 1386 dbSNP
rs1231256522 1393 dbSNP
rs539913464 1395 dbSNP
rs1370495990 1415 dbSNP
rs1212261965 1423 dbSNP
rs1443240530 1430 dbSNP
rs983090674 1436 dbSNP
rs11296996 1437 dbSNP
rs398020798 1437 dbSNP
rs1309706087 1455 dbSNP
rs1239338266 1457 dbSNP
rs1298174071 1462 dbSNP
rs994191785 1466 dbSNP
rs1371016467 1469 dbSNP
rs939286488 1476 dbSNP
rs1448071394 1486 dbSNP
rs1358038366 1487 dbSNP
rs558264298 1488 dbSNP
rs1394931744 1494 dbSNP
rs139964896 1501 dbSNP
rs1159558701 1508 dbSNP
rs1419018765 1515 dbSNP
rs888450118 1517 dbSNP
rs1332071520 1530 dbSNP
rs1006175154 1531 dbSNP
rs752094345 1534 dbSNP
rs1483645171 1536 dbSNP
rs1256875325 1543 dbSNP
rs755727824 1549 dbSNP
rs145416277 1556 dbSNP
rs1489352820 1557 dbSNP
rs562294713 1561 dbSNP
rs574225129 1565 dbSNP
rs183510672 1574 dbSNP
rs1322161252 1592 dbSNP
rs1030094657 1597 dbSNP
rs1226412396 1598 dbSNP
rs1315087148 1615 dbSNP
rs773089739 1620 dbSNP
rs977866014 1621 dbSNP
rs748981340 1622 dbSNP
rs1377884581 1623 dbSNP
rs1290900114 1632 dbSNP
rs936328032 1652 dbSNP
rs1198750019 1657 dbSNP
rs559484281 1659 dbSNP
rs991055898 1682 dbSNP
rs1299218698 1704 dbSNP
rs998911538 1705 dbSNP
rs879179549 1708 dbSNP
rs916808744 1717 dbSNP
rs949570240 1719 dbSNP
rs1167590780 1732 dbSNP
rs1459703272 1734 dbSNP
rs374060808 1742 dbSNP
rs386765656 1742 dbSNP
rs754516281 1742 dbSNP
rs890444437 1742 dbSNP
rs6538881 1743 dbSNP
rs6538882 1744 dbSNP
rs900711296 1750 dbSNP
rs187010424 1770 dbSNP
rs1027748990 1772 dbSNP
rs1222301713 1792 dbSNP
rs564727447 1793 dbSNP
rs191552272 1800 dbSNP
rs1006875885 1808 dbSNP
rs1270743157 1812 dbSNP
rs35746294 1815 dbSNP
rs778619034 1820 dbSNP
rs747950449 1830 dbSNP
rs145263832 1844 dbSNP
rs1031993716 1860 dbSNP
rs1335600352 1863 dbSNP
rs997358006 1864 dbSNP
rs567458422 1875 dbSNP
rs1458875269 1876 dbSNP
rs966562217 1887 dbSNP
rs1162912491 1891 dbSNP
rs1467283316 1892 dbSNP
rs1304875443 1903 dbSNP
rs528353606 1907 dbSNP
rs999711842 1921 dbSNP
rs142293344 1927 dbSNP
rs532475117 1935 dbSNP
rs916506266 1937 dbSNP
rs1191495162 1942 dbSNP
rs771831357 1947 dbSNP
rs1251019706 1976 dbSNP
rs957720499 1977 dbSNP
rs979273919 1977 dbSNP
rs990419629 1979 dbSNP
rs1293116199 1982 dbSNP
rs151008594 1984 dbSNP
rs1313522541 1992 dbSNP
rs1303887363 2003 dbSNP
rs111495253 2008 dbSNP
rs890491538 2010 dbSNP
rs1324526399 2027 dbSNP
rs1219091850 2030 dbSNP
rs181602728 2034 dbSNP
rs1039410730 2045 dbSNP
rs1379539931 2051 dbSNP
rs140896989 2062 dbSNP
rs1211578825 2064 dbSNP
rs1453618386 2070 dbSNP
rs1256278335 2074 dbSNP
rs1485313767 2076 dbSNP
rs900764990 2077 dbSNP
rs1180497549 2080 dbSNP
rs918782899 2083 dbSNP
rs1249220876 2084 dbSNP
rs958272546 2092 dbSNP
rs73142318 2099 dbSNP
rs570134342 2104 dbSNP
rs771023796 2105 dbSNP
rs942690072 2108 dbSNP
rs1429188973 2112 dbSNP
rs1301696665 2113 dbSNP
rs1242956254 2114 dbSNP
rs1336810594 2123 dbSNP
rs1468333708 2126 dbSNP
rs1178295597 2130 dbSNP
rs1328299184 2132 dbSNP
rs1039692589 2134 dbSNP
rs900422581 2149 dbSNP
rs1404407247 2156 dbSNP
rs1303695373 2157 dbSNP
rs776516384 2167 dbSNP
rs1453272904 2168 dbSNP
rs1434330104 2170 dbSNP
rs1286904946 2173 dbSNP
rs997876367 2174 dbSNP
rs1051675099 2175 dbSNP
rs1160170588 2179 dbSNP
rs1400379051 2190 dbSNP
rs1282605662 2191 dbSNP
rs759810056 2198 dbSNP
rs1425087162 2206 dbSNP
rs1220477014 2208 dbSNP
rs769977477 2213 dbSNP
rs1315974341 2219 dbSNP
rs1209791354 2222 dbSNP
rs960698921 2228 dbSNP
rs1278651266 2255 dbSNP
rs767196527 2257 dbSNP
rs1352076784 2279 dbSNP
rs537050382 2280 dbSNP
rs867517776 2282 dbSNP
rs1279530203 2300 dbSNP
rs1237494868 2301 dbSNP
rs990509490 2313 dbSNP
rs1293983376 2315 dbSNP
rs1287707329 2320 dbSNP
rs1414406924 2340 dbSNP
rs1373810083 2344 dbSNP
rs555689924 2352 dbSNP
rs776724492 2357 dbSNP
rs1023695100 2358 dbSNP
rs1011872930 2364 dbSNP
rs1023299004 2365 dbSNP
rs1489511467 2375 dbSNP
rs1368609740 2378 dbSNP
rs1186591768 2418 dbSNP
rs1474049288 2422 dbSNP
rs1217762966 2425 dbSNP
rs1193881262 2429 dbSNP
rs1268857381 2435 dbSNP
rs371739358 2441 dbSNP
rs967976364 2455 dbSNP
rs574265054 2460 dbSNP
rs60760345 2463 dbSNP
rs923798637 2464 dbSNP
rs1418734846 2473 dbSNP
rs1157270607 2481 dbSNP
rs935150135 2482 dbSNP
rs1280363030 2492 dbSNP
rs986999919 2495 dbSNP
rs1362658181 2496 dbSNP
rs911988109 2503 dbSNP
rs763463259 2504 dbSNP
rs553229264 2508 dbSNP
rs1131020 2513 dbSNP
rs577850295 2517 dbSNP
rs1163634283 2518 dbSNP
rs1459442199 2523 dbSNP
rs1302251078 2530 dbSNP
rs1363673084 2533 dbSNP
rs1131021 2534 dbSNP
rs1474837266 2536 dbSNP
rs545187407 2538 dbSNP
rs1438442650 2539 dbSNP
rs1191465040 2554 dbSNP
rs1453880471 2562 dbSNP
rs1274944865 2566 dbSNP
rs1254217196 2570 dbSNP
rs918826263 2571 dbSNP
rs1372059732 2575 dbSNP
rs563089249 2583 dbSNP
rs951647904 2584 dbSNP
rs1039051134 2586 dbSNP
rs1260004520 2588 dbSNP
rs1215448535 2594 dbSNP
rs1338968876 2595 dbSNP
rs1268250630 2597 dbSNP
rs1438310824 2601 dbSNP
rs116928965 2614 dbSNP
rs1049295050 2615 dbSNP
rs909974847 2628 dbSNP
rs752145548 2633 dbSNP
rs1416915395 2639 dbSNP
rs1173933565 2644 dbSNP
rs1455875870 2645 dbSNP
rs886649915 2645 dbSNP
rs1005011301 2651 dbSNP
rs1467525651 2652 dbSNP
rs1240169670 2654 dbSNP
rs1450398022 2662 dbSNP
rs942722787 2663 dbSNP
rs1271185762 2664 dbSNP
rs1221105014 2671 dbSNP
rs1057002696 2677 dbSNP
rs762349701 2680 dbSNP
rs1224350286 2686 dbSNP
rs765914551 2694 dbSNP
rs933989834 2695 dbSNP
rs1279676518 2700 dbSNP
rs1440884193 2703 dbSNP
rs1352215153 2704 dbSNP
rs186272491 2713 dbSNP
rs1434883003 2717 dbSNP
rs1376516871 2718 dbSNP
rs902400573 2725 dbSNP
rs116289685 2731 dbSNP
rs1410762382 2735 dbSNP
rs1000823614 2744 dbSNP
rs760417324 2751 dbSNP
rs1382425323 2752 dbSNP
rs201081099 2761 dbSNP
rs3834481 2761 dbSNP
rs12159 2764 dbSNP
rs1213295732 2769 dbSNP
rs1162703232 2783 dbSNP
rs1411292712 2784 dbSNP
rs1406868773 2787 dbSNP
rs893640468 2788 dbSNP
rs1324206869 2792 dbSNP
rs1223091053 2800 dbSNP
rs113354620 2802 dbSNP
rs879925687 2802 dbSNP
rs986664169 2802 dbSNP
rs1023326440 2803 dbSNP
rs1433282718 2805 dbSNP
rs1353820924 2821 dbSNP
rs1160485194 2822 dbSNP
rs906233648 2823 dbSNP
rs1003188046 2825 dbSNP
rs1405965394 2825 dbSNP
rs1439451476 2830 dbSNP
rs1475684476 2831 dbSNP
rs1257033566 2835 dbSNP
rs1332731854 2840 dbSNP
rs1486735597 2844 dbSNP
rs1261028681 2845 dbSNP
rs1377220111 2858 dbSNP
rs1215069198 2860 dbSNP
rs1451373782 2861 dbSNP
rs930644805 2862 dbSNP
rs1314810193 2865 dbSNP
rs1333476528 2868 dbSNP
rs528420939 2869 dbSNP
rs1401400045 2882 dbSNP
rs1026330077 2883 dbSNP
rs908143667 2885 dbSNP
rs1289811532 2886 dbSNP
rs546952447 2887 dbSNP
rs1430713455 2895 dbSNP
rs1230383369 2900 dbSNP
rs1167235582 2918 dbSNP
rs1462057006 2931 dbSNP
rs1291285509 2932 dbSNP
rs140352209 2939 dbSNP
rs1430520165 2953 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gagUGGACUCGAGGGCACGGAc 5'
             :| |||||  |||||||| 
Target 5' cagGCGUGAGCCACCGUGCCUg 3'
4 - 25
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_181868 | 3UTR | AAAAAGAAAUUAGGAGCCAGGUGCGGUGGCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_181869 | 3UTR | CAUCAGGUUUUAAAAAGCCUUGAAUGGCCCUUGUCUUAAAAAGAAAUUAGGAGCCAGGUGCGGUGGCACGUGCCUGUAAUCCCAGCUCCUUGGGAGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_181868 | 3UTR | AGGUGCGGUGGCACGUGCCUGUAAUCCCAGCUCCUUGGGAGGCUAAGACAGGAGGAUUCCUUGAGCCCUGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_181869 | 3UTR | UUGAAUGGCCCUUGUCUUAAAAAGAAAUUAGGAGCCAGGUGCGGUGGCACGUGCCUGUAAUCCCAGCUCCUUGGGAGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_181861 | 3UTR | AGGUGCGGUGGCACGUGCCUGUAAUCCCAGCUCCUUGGGAGGCUAAGACAGGAGGAUUCCUUGAGCCCUGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084045
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep3
Location of target site ENST00000333991.1 | 3UTR | UUACAGGCGUGAGCCACCGUGCCUGGCCAGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA 0.119 0.39 0.024 0.48 8 Click to see details
THCA 0.119 0.39 0.024 0.48 8 Click to see details
THCA 0.119 0.39 0.024 0.48 8 Click to see details
THCA 0.119 0.39 0.024 0.48 8 Click to see details
THCA 0.119 0.39 0.024 0.48 8 Click to see details
THCA 0.119 0.39 0.024 0.48 8 Click to see details
THCA 0.119 0.39 0.024 0.48 8 Click to see details
61 hsa-miR-3622a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT166678 ZSWIM6 zinc finger SWIM-type containing 6 2 2
MIRT452081 ATP6V0B ATPase H+ transporting V0 subunit b 2 2
MIRT457039 S1PR3 sphingosine-1-phosphate receptor 3 2 2
MIRT471975 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT474065 LMNB2 lamin B2 2 2
MIRT475862 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT476191 GOLGA8A golgin A8 family member A 2 2
MIRT476521 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT483046 C15orf52 chromosome 15 open reading frame 52 2 4
MIRT495541 EIF3H eukaryotic translation initiation factor 3 subunit H 2 2
MIRT495892 CLOCK clock circadian regulator 2 2
MIRT495992 LTBP2 latent transforming growth factor beta binding protein 2 2 2
MIRT496001 EMP1 epithelial membrane protein 1 2 2
MIRT496208 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT496427 ACTRT3 actin related protein T3 2 2
MIRT496438 ZNF704 zinc finger protein 704 2 2
MIRT496473 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT496555 TBX15 T-box 15 2 2
MIRT497202 CECR1 adenosine deaminase 2 2 2
MIRT507632 CREBZF CREB/ATF bZIP transcription factor 2 2
MIRT513377 MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2 2
MIRT523460 GOLGA8J golgin A8 family member J 2 2
MIRT523465 GOLGA8I golgin A8 family member I, pseudogene 1 1
MIRT526049 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT533122 YIPF4 Yip1 domain family member 4 2 2
MIRT534183 SLC8A1 solute carrier family 8 member A1 2 2
MIRT556618 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT563361 WHSC1 nuclear receptor binding SET domain protein 2 2 2
MIRT563868 FAM206A family with sequence similarity 206 member A 2 2
MIRT564360 PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2 2
MIRT564661 ZNF449 zinc finger protein 449 2 2
MIRT564805 ZBTB33 zinc finger and BTB domain containing 33 2 2
MIRT564867 ZBED3 zinc finger BED-type containing 3 2 2
MIRT565340 TMEM104 transmembrane protein 104 2 2
MIRT566439 PHF16 jade family PHD finger 3 2 2
MIRT567587 FCHSD2 FCH and double SH3 domains 2 2 2
MIRT569597 C3orf62 chromosome 3 open reading frame 62 2 2
MIRT569700 FMNL3 formin like 3 2 2
MIRT575957 Nanos1 nanos homolog 1 (Drosophila) 2 3
MIRT576516 Slc35e2 solute carrier family 35, member E2 2 2
MIRT608480 RRP36 ribosomal RNA processing 36 2 2
MIRT614335 NANOS1 nanos C2HC-type zinc finger 1 2 3
MIRT630816 ATAT1 alpha tubulin acetyltransferase 1 2 4
MIRT631708 C1QTNF6 C1q and TNF related 6 2 2
MIRT632369 SRRD SRR1 domain containing 2 2
MIRT633471 DSN1 DSN1 homolog, MIS12 kinetochore complex component 2 2
MIRT634478 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 2
MIRT667336 MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like 2 2
MIRT667654 LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2 2
MIRT671046 SS18 SS18, nBAF chromatin remodeling complex subunit 2 2
MIRT672823 VEZT vezatin, adherens junctions transmembrane protein 2 2
MIRT673049 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT673435 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT676096 DPP9 dipeptidyl peptidase 9 2 2
MIRT678059 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT679783 GOLGA2 golgin A2 2 2
MIRT684219 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT697642 WRN Werner syndrome RecQ like helicase 2 2
MIRT706595 C1RL complement C1r subcomponent like 2 2
MIRT706603 CCS copper chaperone for superoxide dismutase 2 2
MIRT717647 HLX H2.0 like homeobox 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3622a Doxorubicin 31703 NSC123127 approved resistant High Hepatocellular Carcinoma cell line (HepG2)
hsa-mir-3622a Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-miR-3622a-5p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-3622a-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-3622a-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-3622a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3622a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-3622a-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-3622a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-3622a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3622a-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-3622a-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-3622a-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (Panc1-GR3)
hsa-miR-3622a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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