pre-miRNA Information
pre-miRNA hsa-mir-216a   
Genomic Coordinates chr2: 55988950 - 55989059
Description Homo sapiens miR-216a stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216a-5p
Sequence 19| UAAUCUCAGCUGGCAACUGUGA |40
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 15 2 - 55989027 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757094946 2 dbSNP
rs746980700 8 dbSNP
rs1249388997 12 dbSNP
rs1188616124 15 dbSNP
rs1490501989 19 dbSNP
rs1465789697 20 dbSNP
rs370221981 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Tissue .
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol MRPL17   
Synonyms L17mt, LIP2, MRP-L17, MRP-L26, RPL17L, RPML26
Description mitochondrial ribosomal protein L17
Transcript NM_022061   
Expression
Putative miRNA Targets on MRPL17
3'UTR of MRPL17
(miRNA target sites are highlighted)
>MRPL17|NM_022061|3'UTR
   1 CTGGATCTGAAGAGTCTGCAGCCCTTAATCAGTACCCATGATCACAGGCCTTTGGAGCACTTTTACTCTCTGAGAAGAAC
  81 TGGAGCTAGAGATGTAAAATGGACAGTCTTGATGGGGTTGAGAACCTTCTGGGGAGCCAGATGACCCTCTCTTTGCACAA
 161 TAGATAAAAGTCTTTATATGAATATATATAAATTTATTTATTTTTTCCTTCCTGTGGGATTTCTGGAGAATGAGAATTAT
 241 CCAAATGCTCAGTCTACCTGAGATAGTAAATTCATGGCTTATGCTTCTGGTCCTTAAATTTGGGTTATTTTTGGTTAGTG
 321 CAATTTTGTTTTTCTTAATGCCAGTTTACATGGGAATGCATCCTATAATTCCAAATGTTGCCAGAGGTGGTTGTGTTTTG
 401 ACATCTGGTCTCCTAGAGATGAGTGCTTGGGATTTCTTAGAGAAAGATTACTTCCTGACAGGGGTAGGGGAGTGACAATC
 481 TGCAAGTGAAACTTCCTTAAACAATCTAGTACCCTGCGAACCTTCAGGGGATACTGCAATCAGTCCTCTGTTTTGAGGCA
 561 GGATCACACATTACCTTAATGTGTTCCCTTCAACCCCCTGAATGGGCCTGGGAGGAGAGGACCCAAGAACTCAGATGTTC
 641 CACCAGTTTGGCCAAAGGGGTGGAGACATTCAGCAGAGGATGTTGGGCTCCAGGATAAGCTCCTTCCTCTTGGTGAGGGG
 721 AAGGGGTAAGAAAGAGGGTCTATGCGAGAGAAGGATTAGGAAATTAAACCTCCTAGGAATTTCCTGGAAGTTTTTATTGT
 801 TGTCAAATCTGGCCTCTCTGGGAACCCAGAAAAGGGAAATCCGGCTTCAGAATGTGAGAAGCTGGGAGCCCCTTTCTTGG
 881 CACAGCCAGGCTGCCGTTCCCTTGGGTTCAGAGGCTTTAGTAGGGTAGTAGTTATGGAAGGACTTAGAAAGGAGCCATCA
 961 GTCTTGGTCCAAACACTTGATAGCAGTGCCTGATAATTGCCATATCCCCAGTAAAGTGGGTAGAAGAGATTTTATCTTAG
1041 GCTCTATCTTCTGAGTGTATTTGGCCCACTGAACCCATCCACTGTCTGAGATAATAAGTAAGAGTAAGGGTAAAGGGATC
1121 ACTGGTGTAGCAGACATGGCTTCAGTGACAGAACGAACTATTCTGGTGCTAATTTAGCTGTAGCTGCCTTAGTCTGATAC
1201 TCATCTACTCCCAACAGAGCTCTTTATCTCTTTTTCTCTACTATGGTTTGTTCTTCACACTATAGCCAGAAAGCTCTTAT
1281 ATTTTAAATGAAATATAGTAGACACTCAAAACATTTATGAAATAAAGCTACAACTCTGCTTCTGCTAAAAAATATACCCC
1361 TCTTCTGTCTTAGCATGAATATCCACCCTAGCTAGGTATCTAGGAGTCATACCTAACTTCTAGAGAAACCACTTTCCTTA
1441 AAACCACATCTTTATTTTAAATAGATGGATTGTGGCTGGGCTCCTGTAGCTTTTCCTCTTAGACCCCAGAAATATATCTC
1521 CCTTTGGGACTTCCAACAGTTCCCTACATGCTTTTTGAGCATCTGCTAGTTCCCAGCATCAATTTAGGCAGAAGGGATAC
1601 AATATCCACTGTTCATCTAATAGAGACTAGAGATAAGAAACAACCTGTACCATCAATGAGCTCACAATAACAGGCCACTG
1681 CCACTACCACAGTGGCCTCAAGGGACACTGCTTCCCCTTTAATGTTTTGGTCC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aguGUCAACGGUCGACUCUAau 5'
             ||||  |:| |||||||  
Target 5' gctCAGT--CTACCTGAGATag 3'
247 - 266 143.00 -13.60
2
miRNA  3' agUGUCAACGGUCG-ACUCUAAu 5'
            | || ||   || ||:|||| 
Target 5' ctAGAGATGAGTGCTTGGGATTt 3'
413 - 435 136.00 -10.80
3
miRNA  3' agUGUCAACGGUCGACUCUAAu 5'
            | ||| | :||  |||||| 
Target 5' gtAAAGTGGGTAGAAGAGATTt 3'
1011 - 1032 132.00 -12.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30177105 12 COSMIC
COSN30488849 61 COSMIC
COSN19582342 70 COSMIC
COSN7017468 154 COSMIC
COSN30533989 186 COSMIC
COSN1136640 251 COSMIC
COSN7017466 297 COSMIC
COSN32057878 408 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs752567735 2 dbSNP
rs767023973 4 dbSNP
rs759272404 6 dbSNP
rs1044349 7 dbSNP
rs773929337 14 dbSNP
rs8109 15 dbSNP
rs1246307377 16 dbSNP
rs201098149 19 dbSNP
rs776984749 21 dbSNP
rs1188410146 23 dbSNP
rs147348960 24 dbSNP
rs1449460894 28 dbSNP
rs377743005 30 dbSNP
rs966343348 31 dbSNP
rs780490536 35 dbSNP
rs772225682 38 dbSNP
rs185356978 41 dbSNP
rs986564132 45 dbSNP
rs1326251597 47 dbSNP
rs1322508713 72 dbSNP
rs779721310 72 dbSNP
rs1432427883 73 dbSNP
rs1286668655 77 dbSNP
rs933913770 85 dbSNP
rs1317018427 91 dbSNP
rs142774585 96 dbSNP
rs1004586642 101 dbSNP
rs1447859993 105 dbSNP
rs1236554764 112 dbSNP
rs887520808 117 dbSNP
rs975140729 122 dbSNP
rs547924097 131 dbSNP
rs769492289 136 dbSNP
rs1387584495 141 dbSNP
rs1032785939 144 dbSNP
rs1163086406 147 dbSNP
rs11040957 151 dbSNP
rs1402148192 155 dbSNP
rs1404334024 156 dbSNP
rs1344953444 157 dbSNP
rs1387310055 158 dbSNP
rs1452683749 160 dbSNP
rs1338096070 161 dbSNP
rs1380559789 163 dbSNP
rs1301296966 164 dbSNP
rs868684212 165 dbSNP
rs967089913 170 dbSNP
rs543696764 171 dbSNP
rs1352493994 175 dbSNP
rs1225697821 176 dbSNP
rs150563527 178 dbSNP
rs949992434 186 dbSNP
rs913179246 188 dbSNP
rs3177170 190 dbSNP
rs3177171 191 dbSNP
rs896778139 191 dbSNP
rs796632737 192 dbSNP
rs200309634 194 dbSNP
rs564814204 194 dbSNP
rs898511528 195 dbSNP
rs1480362004 196 dbSNP
rs1267388310 197 dbSNP
rs3168317 201 dbSNP
rs1451699209 204 dbSNP
rs1004263215 207 dbSNP
rs1178043320 217 dbSNP
rs1403264040 225 dbSNP
rs1413844389 229 dbSNP
rs575839148 239 dbSNP
rs755020138 240 dbSNP
rs3741276 244 dbSNP
rs1287453262 255 dbSNP
rs116082059 257 dbSNP
rs1015215629 263 dbSNP
rs1224338870 265 dbSNP
rs1265147434 270 dbSNP
rs1040008962 277 dbSNP
rs1200394091 282 dbSNP
rs573351663 284 dbSNP
rs1274280143 292 dbSNP
rs760118498 302 dbSNP
rs193232650 303 dbSNP
rs1005546082 304 dbSNP
rs1180535476 307 dbSNP
rs935909082 313 dbSNP
rs951657022 316 dbSNP
rs1480598263 323 dbSNP
rs1321281440 326 dbSNP
rs925622618 331 dbSNP
rs201183341 334 dbSNP
rs1168454997 339 dbSNP
rs1398596276 350 dbSNP
rs1408117386 351 dbSNP
rs377534198 363 dbSNP
rs72894750 365 dbSNP
rs879268386 367 dbSNP
rs1438671311 377 dbSNP
rs967121123 382 dbSNP
rs1331790199 394 dbSNP
rs11824783 408 dbSNP
rs1045962504 410 dbSNP
rs1329436780 426 dbSNP
rs992360021 429 dbSNP
rs960849838 436 dbSNP
rs1391124119 452 dbSNP
rs1342160058 460 dbSNP
rs1033957002 461 dbSNP
rs1274377638 462 dbSNP
rs141714697 463 dbSNP
rs12283996 464 dbSNP
rs1017353152 465 dbSNP
rs1004169316 471 dbSNP
rs576354288 472 dbSNP
rs1478054233 477 dbSNP
rs187896844 478 dbSNP
rs1447650102 482 dbSNP
rs1167808991 485 dbSNP
rs1190564375 493 dbSNP
rs1426259903 497 dbSNP
rs935929045 500 dbSNP
rs925259769 506 dbSNP
rs1043729625 512 dbSNP
rs1051114417 513 dbSNP
rs1388909613 520 dbSNP
rs932054254 522 dbSNP
rs922073852 527 dbSNP
rs1226854700 531 dbSNP
rs1297454137 533 dbSNP
rs976653689 542 dbSNP
rs944851621 543 dbSNP
rs1459848975 545 dbSNP
rs1264888208 547 dbSNP
rs1487986776 550 dbSNP
rs116639596 554 dbSNP
rs1263220872 566 dbSNP
rs148064689 567 dbSNP
rs1269609062 568 dbSNP
rs925852896 570 dbSNP
rs1041441354 574 dbSNP
rs952290331 581 dbSNP
rs565455327 590 dbSNP
rs551817313 591 dbSNP
rs1321494909 596 dbSNP
rs1452346778 599 dbSNP
rs1027307296 604 dbSNP
rs979795753 605 dbSNP
rs1336717958 607 dbSNP
rs1415604563 611 dbSNP
rs184764594 619 dbSNP
rs569544361 621 dbSNP
rs1384244590 622 dbSNP
rs1024100043 623 dbSNP
rs1398292208 624 dbSNP
rs980925885 626 dbSNP
rs1321425438 629 dbSNP
rs551295068 630 dbSNP
rs1165588478 632 dbSNP
rs1014423600 633 dbSNP
rs891593119 634 dbSNP
rs1450814838 636 dbSNP
rs73399240 637 dbSNP
rs1182637353 652 dbSNP
rs1000046549 655 dbSNP
rs562294289 665 dbSNP
rs1017134595 666 dbSNP
rs904476307 671 dbSNP
rs1179982060 675 dbSNP
rs1419401947 679 dbSNP
rs1182842029 683 dbSNP
rs1414519418 706 dbSNP
rs1455820395 706 dbSNP
rs1158594891 707 dbSNP
rs1406917240 709 dbSNP
rs539918469 727 dbSNP
rs1468033471 733 dbSNP
rs1244806838 737 dbSNP
rs144586459 742 dbSNP
rs1378925758 745 dbSNP
rs545978432 746 dbSNP
rs900504068 752 dbSNP
rs1227398166 759 dbSNP
rs998238073 760 dbSNP
rs1325001166 775 dbSNP
rs1207965712 782 dbSNP
rs1040423278 793 dbSNP
rs944798957 797 dbSNP
rs1480901629 806 dbSNP
rs908011052 807 dbSNP
rs141827250 809 dbSNP
rs930870335 812 dbSNP
rs1471771459 817 dbSNP
rs1298567546 821 dbSNP
rs1245605383 823 dbSNP
rs1181645861 828 dbSNP
rs1430083593 830 dbSNP
rs1434927691 836 dbSNP
rs765492574 842 dbSNP
rs920883168 843 dbSNP
rs191090825 846 dbSNP
rs186681483 848 dbSNP
rs904471850 856 dbSNP
rs1041642111 860 dbSNP
rs1369144412 862 dbSNP
rs979764766 866 dbSNP
rs759690381 876 dbSNP
rs1299964045 879 dbSNP
rs776784621 879 dbSNP
rs1024399716 880 dbSNP
rs574667417 887 dbSNP
rs1482572088 891 dbSNP
rs1370704174 892 dbSNP
rs956002117 893 dbSNP
rs138831248 895 dbSNP
rs1000018626 896 dbSNP
rs534521553 902 dbSNP
rs764158461 906 dbSNP
rs1429636233 911 dbSNP
rs1170972521 914 dbSNP
rs1028156692 917 dbSNP
rs1429468472 921 dbSNP
rs997172373 925 dbSNP
rs12291868 930 dbSNP
rs868063206 935 dbSNP
rs144975670 936 dbSNP
rs3741277 940 dbSNP
rs1295244750 946 dbSNP
rs1341232676 946 dbSNP
rs983014013 955 dbSNP
rs1221866026 956 dbSNP
rs1047918779 960 dbSNP
rs930840517 961 dbSNP
rs1229223049 963 dbSNP
rs1246218138 967 dbSNP
rs920766494 970 dbSNP
rs1029626320 971 dbSNP
rs182485151 972 dbSNP
rs1246771201 988 dbSNP
rs372839585 990 dbSNP
rs16917015 992 dbSNP
rs1416403774 1000 dbSNP
rs1018350370 1006 dbSNP
rs1163560050 1026 dbSNP
rs1345293742 1028 dbSNP
rs115534214 1034 dbSNP
rs1351657977 1038 dbSNP
rs904335917 1040 dbSNP
rs1364430755 1056 dbSNP
rs1020104051 1057 dbSNP
rs1285740381 1074 dbSNP
rs1422245325 1077 dbSNP
rs745552475 1082 dbSNP
rs1289382734 1084 dbSNP
rs1330050779 1098 dbSNP
rs1210724529 1103 dbSNP
rs1266303854 1104 dbSNP
rs1165104721 1113 dbSNP
rs1188771800 1115 dbSNP
rs916899240 1122 dbSNP
rs992929193 1124 dbSNP
rs572939515 1129 dbSNP
rs1180952125 1131 dbSNP
rs937017253 1133 dbSNP
rs1458465657 1135 dbSNP
rs1156388642 1136 dbSNP
rs905638643 1137 dbSNP
rs1470270338 1147 dbSNP
rs1336041891 1148 dbSNP
rs955806226 1150 dbSNP
rs1037437544 1154 dbSNP
rs551985151 1155 dbSNP
rs11040956 1158 dbSNP
rs1433557355 1160 dbSNP
rs982878319 1163 dbSNP
rs1286536255 1165 dbSNP
rs528699864 1168 dbSNP
rs532272498 1170 dbSNP
rs1281298968 1171 dbSNP
rs1472846434 1179 dbSNP
rs922853915 1188 dbSNP
rs977191153 1210 dbSNP
rs1473405890 1219 dbSNP
rs141321309 1222 dbSNP
rs1179500785 1225 dbSNP
rs1410619008 1232 dbSNP
rs1268104960 1236 dbSNP
rs747400607 1236 dbSNP
rs1028125557 1240 dbSNP
rs1478049082 1240 dbSNP
rs138269176 1243 dbSNP
rs1487573047 1245 dbSNP
rs965697390 1250 dbSNP
rs1018932014 1251 dbSNP
rs968759167 1255 dbSNP
rs1009348576 1263 dbSNP
rs1222666717 1265 dbSNP
rs1316679321 1280 dbSNP
rs1282521766 1288 dbSNP
rs569532124 1292 dbSNP
rs1276663732 1294 dbSNP
rs1343559368 1295 dbSNP
rs1219151431 1296 dbSNP
rs1047804913 1305 dbSNP
rs994931273 1315 dbSNP
rs748625699 1328 dbSNP
rs1044605585 1332 dbSNP
rs1035601237 1333 dbSNP
rs1001631815 1338 dbSNP
rs948982618 1339 dbSNP
rs917522707 1344 dbSNP
rs1293747522 1349 dbSNP
rs905546140 1354 dbSNP
rs1169076774 1355 dbSNP
rs1391806470 1356 dbSNP
rs1427536591 1357 dbSNP
rs1056796177 1371 dbSNP
rs191357919 1375 dbSNP
rs934279866 1379 dbSNP
rs1005976124 1383 dbSNP
rs1057038391 1389 dbSNP
rs188572460 1392 dbSNP
rs1298939936 1393 dbSNP
rs1344898739 1395 dbSNP
rs978452846 1400 dbSNP
rs1431505183 1406 dbSNP
rs1274357951 1412 dbSNP
rs968457031 1420 dbSNP
rs1047259500 1423 dbSNP
rs930137483 1432 dbSNP
rs1264673894 1436 dbSNP
rs543470346 1449 dbSNP
rs1189173630 1459 dbSNP
rs570791521 1461 dbSNP
rs1447559688 1462 dbSNP
rs1246456758 1466 dbSNP
rs779287144 1467 dbSNP
rs574453935 1468 dbSNP
rs1458606853 1474 dbSNP
rs965318078 1478 dbSNP
rs1019988985 1483 dbSNP
rs1461025149 1484 dbSNP
rs1321275587 1486 dbSNP
rs1465669820 1500 dbSNP
rs554449625 1504 dbSNP
rs1433526813 1508 dbSNP
rs530299674 1514 dbSNP
rs1313426585 1516 dbSNP
rs950662399 1517 dbSNP
rs1246560738 1519 dbSNP
rs1263272019 1534 dbSNP
rs183574775 1536 dbSNP
rs558312079 1539 dbSNP
rs968831004 1540 dbSNP
rs1269464496 1544 dbSNP
rs1359384104 1547 dbSNP
rs1322164934 1550 dbSNP
rs1463539412 1560 dbSNP
rs1187779370 1561 dbSNP
rs1256609523 1567 dbSNP
rs1435501272 1569 dbSNP
rs994901916 1573 dbSNP
rs538752797 1582 dbSNP
rs1023121509 1589 dbSNP
rs1405164043 1595 dbSNP
rs988675133 1596 dbSNP
rs1160089631 1599 dbSNP
rs756352520 1600 dbSNP
rs750683474 1606 dbSNP
rs1288749938 1608 dbSNP
rs1403393356 1613 dbSNP
rs550818060 1621 dbSNP
rs1398195104 1624 dbSNP
rs576076058 1625 dbSNP
rs1310996852 1626 dbSNP
rs1334586268 1631 dbSNP
rs1228617359 1632 dbSNP
rs1289683296 1633 dbSNP
rs1057495630 1635 dbSNP
rs934925214 1637 dbSNP
rs1326383727 1641 dbSNP
rs1208067051 1645 dbSNP
rs902832826 1651 dbSNP
rs1035909131 1656 dbSNP
rs1176830051 1657 dbSNP
rs1001473790 1663 dbSNP
rs1475007905 1663 dbSNP
rs1414313243 1665 dbSNP
rs150457970 1671 dbSNP
rs772986562 1686 dbSNP
rs1378764998 1687 dbSNP
rs970345745 1697 dbSNP
rs767276524 1699 dbSNP
rs535878162 1702 dbSNP
rs1410067856 1705 dbSNP
rs1309415283 1711 dbSNP
rs947123529 1714 dbSNP
rs200384683 1721 dbSNP
rs886222895 1723 dbSNP
rs1313947749 1724 dbSNP
rs1230895144 1727 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agUGUCAACGGUCGACUCUAAu 5'
            :||| ||  |||||||||| 
Target 5' uuGCAG-UG--AGCUGAGAUUg 3'
4 - 22
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084045
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep3
Location of target site ENST00000288937.6 | 3UTR | AGCUUGCAGUGAGCUGAGAUUGUGCCACUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells -0.56 2.7e-3 -0.302 8.1e-2 23 Click to see details
GSE28544 Breast cancer -0.445 1.5e-2 -0.440 1.6e-2 24 Click to see details
GSE38226 Liver fibrosis 0.324 7.6e-2 0.144 2.7e-1 21 Click to see details
GSE21849 B cell lymphoma -0.262 8.5e-2 -0.308 5.2e-2 29 Click to see details
GSE28260 Renal cortex and medulla -0.392 9.3e-2 -0.287 1.7e-1 13 Click to see details
GSE32688 Pancreatic cancer -0.239 9.4e-2 -0.081 3.3e-1 32 Click to see details
GSE26953 Aortic valvular endothelial cells 0.243 1.3e-1 0.307 7.2e-2 24 Click to see details
GSE19350 CNS germ cell tumors -0.354 1.3e-1 0.096 3.8e-1 12 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.186 1.9e-1 0.232 1.3e-1 25 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.184 2.2e-1 -0.012 4.8e-1 20 Click to see details
GSE21687 Ependynoma primary tumors 0.096 2.3e-1 0.087 2.5e-1 64 Click to see details
GSE14794 Lymphoblastoid cells -0.075 2.4e-1 -0.062 2.8e-1 90 Click to see details
GSE17498 Multiple myeloma -0.068 3.4e-1 -0.071 3.3e-1 40 Click to see details
GSE17306 Multiple myeloma 0.03 4.2e-1 0.452 5.6e-4 49 Click to see details
GSE27834 Pluripotent stem cells -0.044 4.4e-1 0.144 3.0e-1 16 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.024 4.5e-1 0.541 2.6e-3 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC 0.502 0.01 0.441 0.03 20 Click to see details
BLCA 0.472 0.08 0.394 0.13 10 Click to see details
CHOL 0.48 0.11 0.548 0.08 8 Click to see details
KIRC 0.212 0.13 0.279 0.07 29 Click to see details
LIHC -0.158 0.15 -0.131 0.2 45 Click to see details
KICH -0.337 0.16 -0.482 0.07 11 Click to see details
BRCA 0.209 0.16 0.184 0.19 25 Click to see details
KIRP 0.193 0.22 0.131 0.3 18 Click to see details
THCA -0.105 0.24 -0.125 0.2 47 Click to see details
LUAD 0.256 0.25 0.250 0.26 9 Click to see details
PRAD -0.121 0.26 -0.041 0.41 31 Click to see details
STAD 0.13 0.29 -0.044 0.43 20 Click to see details
PAAD -0.36 0.32 -0.600 0.2 4 Click to see details
UCEC 0.15 0.34 -0.224 0.27 10 Click to see details
ESCA 0.185 0.41 0.000 0.5 4 Click to see details
HNSC 0.03 0.45 0.014 0.47 23 Click to see details
HNSC 0.03 0.45 0.014 0.47 23 Click to see details
HNSC 0.03 0.45 0.014 0.47 23 Click to see details
148 hsa-miR-216a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000534 PTEN phosphatase and tensin homolog 4 3
MIRT005018 SIRT1 sirtuin 1 3 1
MIRT005964 CDC42 cell division cycle 42 2 1
MIRT005969 CD44 CD44 molecule (Indian blood group) 2 1
MIRT007154 SMAD7 SMAD family member 7 1 1
MIRT054887 BECN1 beclin 1 5 3
MIRT067588 METAP2 methionyl aminopeptidase 2 2 6
MIRT099144 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT162313 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT230668 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT256274 PHAX phosphorylated adaptor for RNA export 2 2
MIRT386817 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT386825 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT438816 HNF4A hepatocyte nuclear factor 4 alpha 1 1
MIRT464699 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465962 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466046 TMEM189 transmembrane protein 189 2 2
MIRT466482 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT472209 NGFRAP1 brain expressed X-linked 3 2 4
MIRT472562 NACC1 nucleus accumbens associated 1 2 4
MIRT478921 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT480121 CALR calreticulin 2 2
MIRT497754 OXGR1 oxoglutarate receptor 1 2 2
MIRT497967 TWISTNB TWIST neighbor 2 2
MIRT502882 CDK4 cyclin dependent kinase 4 2 8
MIRT510191 MON1B MON1 homolog B, secretory trafficking associated 2 4
MIRT512407 CD84 CD84 molecule 2 2
MIRT513739 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT526257 DROSHA drosha ribonuclease III 2 2
MIRT528968 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT529599 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT529776 ZNF486 zinc finger protein 486 2 2
MIRT530110 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530504 FADS6 fatty acid desaturase 6 2 2
MIRT531437 PAK1 p21 (RAC1) activated kinase 1 2 2
MIRT534445 SDR16C5 short chain dehydrogenase/reductase family 16C member 5 2 2
MIRT537286 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT538451 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT543085 ACTB actin beta 2 2
MIRT550982 ZNF254 zinc finger protein 254 2 2
MIRT556259 MAPRE2 microtubule associated protein RP/EB family member 2 2 2
MIRT556639 LAMC1 laminin subunit gamma 1 2 2
MIRT559127 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT561405 TUBB2A tubulin beta 2A class IIa 2 2
MIRT569677 SEC23B Sec23 homolog B, coat complex II component 2 4
MIRT574660 KLHL15 kelch like family member 15 2 2
MIRT575030 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT617683 JRKL JRK like 2 2
MIRT618540 SEMA5A semaphorin 5A 2 2
MIRT620805 C1orf27 chromosome 1 open reading frame 27 2 2
MIRT621569 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT622133 SP4 Sp4 transcription factor 2 2
MIRT624913 CTCFL CCCTC-binding factor like 2 2
MIRT625010 PAK4 p21 (RAC1) activated kinase 4 2 2
MIRT626644 ZNF551 zinc finger protein 551 2 2
MIRT626646 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT626672 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT627945 NNT nicotinamide nucleotide transhydrogenase 2 2
MIRT627963 NLK nemo like kinase 2 2
MIRT628767 SRSF7 serine and arginine rich splicing factor 7 2 2
MIRT629261 KDM2B lysine demethylase 2B 2 2
MIRT629422 ADM2 adrenomedullin 2 2 2
MIRT630238 SORD sorbitol dehydrogenase 2 2
MIRT631272 CENPM centromere protein M 2 4
MIRT631793 CLK4 CDC like kinase 4 2 2
MIRT632058 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT632485 RPS15A ribosomal protein S15a 2 2
MIRT632611 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632708 MTA3 metastasis associated 1 family member 3 2 2
MIRT632815 INO80 INO80 complex subunit 2 2
MIRT635956 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636152 UBXN2A UBX domain protein 2A 2 2
MIRT636899 C5orf45 MRN complex interacting protein 2 4
MIRT636930 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT637457 ZNF324B zinc finger protein 324B 2 2
MIRT637900 SLC19A3 solute carrier family 19 member 3 2 2
MIRT639826 ZNF638 zinc finger protein 638 2 2
MIRT640445 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT640681 ARSK arylsulfatase family member K 2 2
MIRT641611 CAPN7 calpain 7 2 2
MIRT641676 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT646786 IL23R interleukin 23 receptor 2 2
MIRT648352 A2ML1 alpha-2-macroglobulin like 1 2 2
MIRT649144 SPATA5 spermatogenesis associated 5 2 2
MIRT649254 TRIM65 tripartite motif containing 65 2 2
MIRT652491 TMEM178B transmembrane protein 178B 2 2
MIRT653308 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT653945 SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2 2
MIRT654212 RNF19B ring finger protein 19B 2 2
MIRT654839 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT655159 PHF21A PHD finger protein 21A 2 2
MIRT655316 PDCD11 programmed cell death 11 2 2
MIRT655375 PAX3 paired box 3 2 2
MIRT657301 HOXB5 homeobox B5 2 2
MIRT657593 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT658460 FAM117B family with sequence similarity 117 member B 2 2
MIRT658716 ELOVL4 ELOVL fatty acid elongase 4 2 2
MIRT661640 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT661712 MTO1 mitochondrial tRNA translation optimization 1 2 4
MIRT661833 ZNF793 zinc finger protein 793 2 2
MIRT663805 BET1L Bet1 golgi vesicular membrane trafficking protein like 2 2
MIRT663884 CXorf56 chromosome X open reading frame 56 2 2
MIRT664672 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 2
MIRT665814 TMEM168 transmembrane protein 168 2 2
MIRT668159 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668430 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT672306 GP2 glycoprotein 2 2 2
MIRT673101 SYNPO2L synaptopodin 2 like 2 2
MIRT673437 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT673584 KDELC2 KDEL motif containing 2 2 2
MIRT673718 SLU7 SLU7 homolog, splicing factor 2 2
MIRT673777 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT674316 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT674820 FAM229B family with sequence similarity 229 member B 2 2
MIRT675179 BPTF bromodomain PHD finger transcription factor 2 2
MIRT675586 WWC1 WW and C2 domain containing 1 2 2
MIRT675812 MED28 mediator complex subunit 28 2 2
MIRT677632 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT683914 PSMB9 proteasome subunit beta 9 2 2
MIRT687135 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT691973 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT693078 AS3MT arsenite methyltransferase 2 2
MIRT694084 RNASEH2B ribonuclease H2 subunit B 2 2
MIRT696292 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT696541 C3 complement C3 2 2
MIRT701955 MITF melanogenesis associated transcription factor 2 2
MIRT703276 GNG12 G protein subunit gamma 12 2 2
MIRT706852 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT706993 XPO5 exportin 5 2 2
MIRT710716 KRTAP6-1 keratin associated protein 6-1 2 2
MIRT711305 ACOX1 acyl-CoA oxidase 1 2 2
MIRT711514 ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2 2
MIRT711648 LIPG lipase G, endothelial type 2 2
MIRT711772 CCDC59 coiled-coil domain containing 59 2 2
MIRT714280 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT715048 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT716934 INCENP inner centromere protein 2 2
MIRT717220 OTUD3 OTU deubiquitinase 3 2 2
MIRT717865 BICD2 BICD cargo adaptor 2 2 2
MIRT718836 SNX20 sorting nexin 20 2 2
MIRT720243 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT721969 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT724000 LMTK2 lemur tyrosine kinase 2 2 2
MIRT725193 SDAD1 SDA1 domain containing 1 2 2
MIRT731669 CBL Cbl proto-oncogene 3 1
MIRT732776 AQP4 aquaporin 4 3 0
MIRT733158 ITGA5 integrin subunit alpha 5 1 0
MIRT735623 TLR4 toll like receptor 4 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216a Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216a Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3, 2008, OVCAR10, OVCAR3, HeLa, MCF7, MDA-MB-468)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved sensitive High Small Cell Lung Cancer cell line (NCI-H69)
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant Low Hepatocellular Carcinoma tissue and cell line (HepG2, Hep3B, Huh-7, PLC/PRF/5, HCCLM3, Bel-7404, HLE, SK-HEP-1, SNU-449)
hsa-miR-216a-5p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant Low Small Cell Lung Cancer cell line (H69, H446)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant Low Ovarian Cancer cell line (SKOV3, OVCA433)
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant Low Gastric Cancer cell line (MGC, SGC)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-216a-5p Exemestane 60198 NSC713563 approved sensitive cell line (MCF-7)
hsa-miR-216a-5p Testosterone+Tamoxifen sensitive cell line (MCF-7)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-216a-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

Error report submission