pre-miRNA Information
pre-miRNA hsa-mir-452   
Genomic Coordinates chrX: 151959628 - 151959712
Synonyms MIRN452, hsa-mir-452, MIR452
Description Homo sapiens miR-452 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-452-3p
Sequence 58| CUCAUCUGCAAAGAAGUAAGUG |79
Evidence Experimental
Experiments Array-cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 X - 151959644 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757928550 3 dbSNP
rs1324216965 6 dbSNP
rs1390793899 13 dbSNP
rs899383242 17 dbSNP
rs747858567 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol NUP62   
Synonyms IBSN, SNDI, p62
Description nucleoporin 62
Transcript NM_012346   
Other Transcripts NM_016553 , NM_153718 , NM_153719   
Expression
Putative miRNA Targets on NUP62
3'UTR of NUP62
(miRNA target sites are highlighted)
>NUP62|NM_012346|3'UTR
   1 GCGACAGCAGCCCTGGGGCCCGCAGGTCCCTAGGGAGTTCATGAGGGGAATGCGCCCTGTTGTCTGTAGTTTGGGGTTGT
  81 GGCAAGATACTTGTTTGTTTGTTTCTTTCTTTCACATGACTGCCCTTGACATGATCGCTGTGTGCTTTGCGTTTTTCCAT
 161 TTAGGAGGGTATTCTGGGCCTTCTGCCCAGGCAGCAGCCTCATGGGTGTGGCTTCTGTGGCTTTCATTTGAGTATCTTTG
 241 GCCCCTTTTCACCTACTGCGACCACCCACCTCATCCTGGCTCAGCCTGGTGATGGAGAAGTGCTGATGGTCTTGGTCCCA
 321 GCCAGGGTCGTGGGGGCAGCCACTCTCTCCAAAGCATAGTCATAGGTGTCATGAAAAAATACCAAATGTAAGAGAACCTC
 401 CAAGTCAGGGCGCAGTGGCTCACCCCTGTAATCTCAGCACTTTGGGTGGCCAAGGCGGGCAGATGACTTGAGGTCAGGAG
 481 TTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGTCAGGTGTGGTGGACGCCTG
 561 TGATCTCAATCTCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGTGTTGCAGTGAACCAAGATCA
 641 CACCACTGCACTCCAGCCTAGGCAACAGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAGAAACTCCCAGGAGACAGC
 721 AGCCTAGTTTTCGAGTGTGAGCTTGTGCTTGTGAAAGCTAACCATGCTAACCACCAAGGCAAAGCAGCACAGTGTGAATA
 801 GAACAGAGCGGGATCAAGAATTTCACAGAAGACAGGTCAGCTGAGGGGCCTGCACACACAGGGTGTTGAGGAACCACAGA
 881 TGGGCGCCGAGAGGCCTGCCTTTTGCCTGGCCCAGGCTCACCCCCACCTTGGGCCTCACCTCCTCCAGGAAGCCTTCCCA
 961 GCTACCCGAAGCTCAGGTGGCCTTCTTGCAGGTCCCCGTAGCACCCTGAGCCTGTACCTTGGGTGGCACTTGTTATGCTA
1041 TCCTGTGCTAGCCGTTTGTGCCTCGTCTCGCTGTTAGATTGTGAGTTCCCATGGGCAGAGACCCACTGTCGTTCCCCGTG
1121 TGTCCCCAGCCCGGTCCCTGTCACATTTGTTAAATGAAAGAACAATGAAGCCCAGTGTAACGTCAGTCCACAGAAATAGC
1201 CACAGCTTCCAGTGGTGGCCGTAGACTTGGCTCGGAACTTAGTGGCACCAGAGTAACTCTAGTCAGTTACAGTAAAATCC
1281 ACTGTGTGTGGAAGGCAGAAGCTAGCGGTTGTATCCCAAGCATCTTTTGTATTTGTCTTTATACTTTGCTGAATTCTCTG
1361 AAATACCTATTACTGTATGTTGCTTTTCTAAATAAATGTATTGTGAAACCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gugaaugaagaaaCGUCUACUc 5'
                       |||||||| 
Target 5' gtggccaaggcggGCAGATGAc 3'
446 - 467 145.00 -11.40
2
miRNA  3' guGAAUGAAGAAACGUCUACUc 5'
            :|| :|||||| || |||| 
Target 5' tgTTTCTTTCTTT-CACATGAc 3'
100 - 120 139.00 -7.80
3
miRNA  3' gugaaugaagaaacGUCUACUc 5'
                        ||||||: 
Target 5' gtgttgaggaaccaCAGATGGg 3'
863 - 884 124.00 -11.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31495067 25 COSMIC
COSN30134016 33 COSMIC
COSN31519230 40 COSMIC
COSN31583733 41 COSMIC
COSN30538132 82 COSMIC
COSN24107439 134 COSMIC
COSN8261543 453 COSMIC
COSN4778509 839 COSMIC
COSN7447919 849 COSMIC
COSN21570364 889 COSMIC
COSN21621382 1302 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs372281472 2 dbSNP
rs375449846 3 dbSNP
rs765043638 10 dbSNP
rs761632740 15 dbSNP
rs1308346592 19 dbSNP
rs764355720 21 dbSNP
rs760945372 22 dbSNP
rs775435783 23 dbSNP
rs1401400885 30 dbSNP
rs1218592190 33 dbSNP
rs1423869890 39 dbSNP
rs1416667336 40 dbSNP
rs1180647216 41 dbSNP
rs1482975166 46 dbSNP
rs772132592 48 dbSNP
rs906846027 53 dbSNP
rs45540835 54 dbSNP
rs1472067116 56 dbSNP
rs1277439580 65 dbSNP
rs948649371 71 dbSNP
rs532206411 78 dbSNP
rs186001015 79 dbSNP
rs1355200327 83 dbSNP
rs1457811940 90 dbSNP
rs775828349 93 dbSNP
rs955675213 95 dbSNP
rs1486986271 97 dbSNP
rs11547267 101 dbSNP
rs919347451 105 dbSNP
rs975633969 105 dbSNP
rs1017075889 106 dbSNP
rs1006014943 110 dbSNP
rs1160611393 116 dbSNP
rs951878189 129 dbSNP
rs1290271799 130 dbSNP
rs972098514 131 dbSNP
rs1419116523 132 dbSNP
rs145144537 137 dbSNP
rs1402783247 147 dbSNP
rs993551209 148 dbSNP
rs1331938417 149 dbSNP
rs896127652 150 dbSNP
rs745899876 151 dbSNP
rs1350893825 154 dbSNP
rs1379130346 171 dbSNP
rs774427219 179 dbSNP
rs1347750433 181 dbSNP
rs1199183948 189 dbSNP
rs953798627 189 dbSNP
rs1255906795 191 dbSNP
rs1458464204 192 dbSNP
rs1002040433 200 dbSNP
rs560839227 202 dbSNP
rs1465260543 203 dbSNP
rs905035903 208 dbSNP
rs1439201796 210 dbSNP
rs1174334003 213 dbSNP
rs1022507279 215 dbSNP
rs771070946 216 dbSNP
rs1350709603 218 dbSNP
rs1467537130 224 dbSNP
rs1011501113 234 dbSNP
rs892608821 240 dbSNP
rs1401275943 242 dbSNP
rs1031445287 252 dbSNP
rs1333011361 256 dbSNP
rs1403951873 260 dbSNP
rs946852094 263 dbSNP
rs998631479 265 dbSNP
rs1413597495 269 dbSNP
rs1159722278 271 dbSNP
rs141228323 273 dbSNP
rs1319093132 280 dbSNP
rs1200872716 281 dbSNP
rs1045460612 291 dbSNP
rs1176266781 301 dbSNP
rs1480055932 305 dbSNP
rs1191934781 308 dbSNP
rs948372084 308 dbSNP
rs1431474317 313 dbSNP
rs933998689 329 dbSNP
rs181506876 330 dbSNP
rs1403296621 336 dbSNP
rs563111900 337 dbSNP
rs1044276 338 dbSNP
rs11547266 341 dbSNP
rs975666499 343 dbSNP
rs1293711355 344 dbSNP
rs942928991 354 dbSNP
rs910084066 356 dbSNP
rs930489890 358 dbSNP
rs919114656 359 dbSNP
rs1319683430 362 dbSNP
rs9523 364 dbSNP
rs1276709662 381 dbSNP
rs1317609742 383 dbSNP
rs1222631840 397 dbSNP
rs546501513 402 dbSNP
rs1026501227 409 dbSNP
rs374146319 410 dbSNP
rs371234041 411 dbSNP
rs911974511 412 dbSNP
rs986097884 414 dbSNP
rs1195669366 416 dbSNP
rs1034607016 421 dbSNP
rs145149204 424 dbSNP
rs1002113969 425 dbSNP
rs1351224845 427 dbSNP
rs191069827 430 dbSNP
rs989727552 434 dbSNP
rs1360539827 438 dbSNP
rs1349594121 444 dbSNP
rs957162107 445 dbSNP
rs1299229010 447 dbSNP
rs1422009046 452 dbSNP
rs1378984346 456 dbSNP
rs1158620706 457 dbSNP
rs1031206650 459 dbSNP
rs1425327921 460 dbSNP
rs1192508127 461 dbSNP
rs1011177294 463 dbSNP
rs1267867534 465 dbSNP
rs1217089545 468 dbSNP
rs1489176766 470 dbSNP
rs1182223902 473 dbSNP
rs1003708886 480 dbSNP
rs1421698702 482 dbSNP
rs1162457656 483 dbSNP
rs1127729 484 dbSNP
rs1420935947 484 dbSNP
rs1024026271 491 dbSNP
rs1345088320 497 dbSNP
rs1013009560 511 dbSNP
rs894117649 514 dbSNP
rs1049185956 515 dbSNP
rs994793331 533 dbSNP
rs1377357505 534 dbSNP
rs3859440 538 dbSNP
rs1310197473 541 dbSNP
rs1238015450 545 dbSNP
rs1367201268 545 dbSNP
rs901215427 547 dbSNP
rs569495944 548 dbSNP
rs1039719557 551 dbSNP
rs1036192912 552 dbSNP
rs942961208 555 dbSNP
rs910116497 556 dbSNP
rs1182624743 565 dbSNP
rs944503832 567 dbSNP
rs551138336 569 dbSNP
rs538382570 573 dbSNP
rs571314916 574 dbSNP
rs911985770 581 dbSNP
rs1050506535 582 dbSNP
rs972225355 586 dbSNP
rs931996327 587 dbSNP
rs1207677220 603 dbSNP
rs1487644631 604 dbSNP
rs1265050568 608 dbSNP
rs1245675079 611 dbSNP
rs1299786015 612 dbSNP
rs1323569160 613 dbSNP
rs915271551 616 dbSNP
rs759982814 619 dbSNP
rs1314847400 620 dbSNP
rs546317922 622 dbSNP
rs1349744526 623 dbSNP
rs1368308401 624 dbSNP
rs1428201684 624 dbSNP
rs1288786675 631 dbSNP
rs528083527 637 dbSNP
rs1388198139 638 dbSNP
rs1292571966 640 dbSNP
rs1299151247 641 dbSNP
rs1421862671 642 dbSNP
rs1310273591 646 dbSNP
rs771534605 647 dbSNP
rs1351125486 648 dbSNP
rs1156241753 649 dbSNP
rs1472561857 656 dbSNP
rs1413287091 657 dbSNP
rs1458806042 662 dbSNP
rs1176337019 664 dbSNP
rs1231820608 668 dbSNP
rs1184834118 670 dbSNP
rs1374048891 672 dbSNP
rs749721095 673 dbSNP
rs767699595 673 dbSNP
rs778271976 674 dbSNP
rs1175903179 676 dbSNP
rs1415548086 678 dbSNP
rs1267008676 679 dbSNP
rs1210656635 680 dbSNP
rs1489549529 681 dbSNP
rs762042884 681 dbSNP
rs1034678771 682 dbSNP
rs1491035750 682 dbSNP
rs1402830302 686 dbSNP
rs1266342309 688 dbSNP
rs1208144260 691 dbSNP
rs1328444941 692 dbSNP
rs1268667965 693 dbSNP
rs751769989 694 dbSNP
rs989876245 694 dbSNP
rs768263073 695 dbSNP
rs1438679166 696 dbSNP
rs746610162 696 dbSNP
rs61338594 697 dbSNP
rs982282641 698 dbSNP
rs1280097884 699 dbSNP
rs1212332225 701 dbSNP
rs1491369382 701 dbSNP
rs1005012763 702 dbSNP
rs1196407122 702 dbSNP
rs1223121211 702 dbSNP
rs1245540241 702 dbSNP
rs1271823353 702 dbSNP
rs1319653832 702 dbSNP
rs1364976874 702 dbSNP
rs1480402045 702 dbSNP
rs4009637 702 dbSNP
rs5828417 702 dbSNP
rs759363509 702 dbSNP
rs762766968 702 dbSNP
rs764413393 702 dbSNP
rs775167721 702 dbSNP
rs869180975 702 dbSNP
rs1298692166 703 dbSNP
rs373706111 703 dbSNP
rs373724192 704 dbSNP
rs746535490 705 dbSNP
rs1229620226 706 dbSNP
rs1288964838 706 dbSNP
rs1356591956 706 dbSNP
rs749617319 706 dbSNP
rs969005914 706 dbSNP
rs779447445 707 dbSNP
rs1218013768 711 dbSNP
rs1353879572 711 dbSNP
rs1022183549 718 dbSNP
rs1024078223 722 dbSNP
rs1012690905 726 dbSNP
rs370422917 732 dbSNP
rs548884388 733 dbSNP
rs1027356302 739 dbSNP
rs1473907975 740 dbSNP
rs1161616276 742 dbSNP
rs1384723578 746 dbSNP
rs956748879 747 dbSNP
rs994909142 752 dbSNP
rs1030832604 755 dbSNP
rs897750351 764 dbSNP
rs1036204360 765 dbSNP
rs1380367979 766 dbSNP
rs1334792593 768 dbSNP
rs1180117278 769 dbSNP
rs1449815889 773 dbSNP
rs1312396650 777 dbSNP
rs998712024 782 dbSNP
rs1008698909 792 dbSNP
rs1240206709 800 dbSNP
rs1258806142 802 dbSNP
rs890264676 806 dbSNP
rs1050670197 809 dbSNP
rs754991983 810 dbSNP
rs893876691 814 dbSNP
rs751060095 816 dbSNP
rs1251057362 822 dbSNP
rs1053792063 831 dbSNP
rs548980353 839 dbSNP
rs1342676722 840 dbSNP
rs1039748960 842 dbSNP
rs758048701 844 dbSNP
rs1452566180 847 dbSNP
rs1381318322 848 dbSNP
rs1242738105 856 dbSNP
rs982336521 857 dbSNP
rs750088770 858 dbSNP
rs75368221 861 dbSNP
rs151270836 862 dbSNP
rs577315096 868 dbSNP
rs991387540 879 dbSNP
rs1402669534 884 dbSNP
rs1167009635 885 dbSNP
rs1057291496 886 dbSNP
rs565372770 888 dbSNP
rs186984993 889 dbSNP
rs1239001367 893 dbSNP
rs927737722 893 dbSNP
rs973101013 897 dbSNP
rs1202162604 898 dbSNP
rs545044451 911 dbSNP
rs1262815879 917 dbSNP
rs56779488 919 dbSNP
rs1238822844 923 dbSNP
rs142182842 926 dbSNP
rs1008795110 930 dbSNP
rs890361510 935 dbSNP
rs1418528013 941 dbSNP
rs760040332 941 dbSNP
rs1378100606 942 dbSNP
rs1478926584 943 dbSNP
rs1173973810 945 dbSNP
rs8429 946 dbSNP
rs1332911449 947 dbSNP
rs1465822522 947 dbSNP
rs1393723985 949 dbSNP
rs1390293582 950 dbSNP
rs893896823 953 dbSNP
rs1054250123 957 dbSNP
rs1031282729 966 dbSNP
rs1222154279 967 dbSNP
rs538005990 968 dbSNP
rs1444579555 978 dbSNP
rs1358892775 981 dbSNP
rs1264054787 988 dbSNP
rs902537952 997 dbSNP
rs180934958 998 dbSNP
rs1480370757 1002 dbSNP
rs1210508051 1005 dbSNP
rs949649806 1012 dbSNP
rs1018383945 1013 dbSNP
rs539212905 1028 dbSNP
rs916814913 1036 dbSNP
rs888449531 1040 dbSNP
rs571708629 1041 dbSNP
rs1172439243 1042 dbSNP
rs1370956326 1043 dbSNP
rs1461093477 1048 dbSNP
rs931440112 1053 dbSNP
rs994860166 1054 dbSNP
rs897388579 1064 dbSNP
rs140472122 1065 dbSNP
rs938868779 1067 dbSNP
rs147222334 1069 dbSNP
rs1044795143 1070 dbSNP
rs1245723559 1071 dbSNP
rs1267309495 1078 dbSNP
rs45577034 1080 dbSNP
rs1160423407 1082 dbSNP
rs1220198530 1083 dbSNP
rs914926445 1085 dbSNP
rs989149284 1091 dbSNP
rs1014554932 1093 dbSNP
rs1259328938 1102 dbSNP
rs555667842 1104 dbSNP
rs548552246 1108 dbSNP
rs1422190887 1110 dbSNP
rs537044484 1110 dbSNP
rs111373388 1111 dbSNP
rs976636738 1116 dbSNP
rs996055389 1117 dbSNP
rs563598151 1118 dbSNP
rs1032153443 1119 dbSNP
rs1315053797 1121 dbSNP
rs1357441010 1126 dbSNP
rs1222189901 1132 dbSNP
rs11083988 1133 dbSNP
rs1217772263 1139 dbSNP
rs1258770121 1140 dbSNP
rs1485391779 1142 dbSNP
rs533162053 1145 dbSNP
rs1288781059 1148 dbSNP
rs1442312846 1160 dbSNP
rs1027427053 1163 dbSNP
rs902567575 1164 dbSNP
rs143688089 1165 dbSNP
rs1278445974 1166 dbSNP
rs1157508582 1172 dbSNP
rs1344996354 1174 dbSNP
rs897121324 1175 dbSNP
rs1013589990 1176 dbSNP
rs1338994615 1181 dbSNP
rs1035955779 1182 dbSNP
rs895432901 1189 dbSNP
rs1055771034 1195 dbSNP
rs931521699 1197 dbSNP
rs1281033571 1201 dbSNP
rs1310082777 1211 dbSNP
rs1379153639 1218 dbSNP
rs770088909 1220 dbSNP
rs1282034546 1221 dbSNP
rs62126289 1223 dbSNP
rs1210551617 1225 dbSNP
rs1361003417 1233 dbSNP
rs1459712612 1239 dbSNP
rs114164962 1245 dbSNP
rs189025201 1254 dbSNP
rs1238290259 1260 dbSNP
rs1398895092 1261 dbSNP
rs907589509 1265 dbSNP
rs1176039673 1266 dbSNP
rs1384297005 1282 dbSNP
rs534293886 1283 dbSNP
rs1434187099 1284 dbSNP
rs954516048 1298 dbSNP
rs575889617 1306 dbSNP
rs115030648 1307 dbSNP
rs1332233739 1308 dbSNP
rs1356400501 1315 dbSNP
rs975086152 1319 dbSNP
rs1478347369 1322 dbSNP
rs1265816174 1324 dbSNP
rs11547265 1331 dbSNP
rs1215007595 1333 dbSNP
rs545327924 1335 dbSNP
rs1446959669 1337 dbSNP
rs28586965 1342 dbSNP
rs1219676327 1344 dbSNP
rs1200507530 1347 dbSNP
rs1032186441 1348 dbSNP
rs754900634 1356 dbSNP
rs184961731 1366 dbSNP
rs893539738 1369 dbSNP
rs1439090849 1371 dbSNP
rs1201824932 1377 dbSNP
rs1232871398 1379 dbSNP
rs1346554958 1380 dbSNP
rs535947677 1385 dbSNP
rs1194846295 1387 dbSNP
rs566897667 1395 dbSNP
rs1260859348 1399 dbSNP
rs74961846 1410 dbSNP
rs1202170459 1411 dbSNP
rs1427664551 1415 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset Chi_124B_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + B
Location of target site ENST00000422090.2 | 3UTR | AGAUGACUUGAGGUCAGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000422090.2 | 3UTR | AGAUGACUUGAGGUCAGGAGUUCGAGACCAGCCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38974 Chronic obstructive pulmonary disease 0.496 5.8e-3 0.570 1.5e-3 25 Click to see details
GSE32688 Pancreatic cancer 0.291 5.3e-2 0.288 5.5e-2 32 Click to see details
GSE19350 CNS germ cell tumors -0.489 5.3e-2 0.154 3.2e-1 12 Click to see details
GSE28260 Renal cortex and medulla -0.441 6.6e-2 -0.148 3.1e-1 13 Click to see details
GSE21849 B cell lymphoma -0.268 8.0e-2 -0.032 4.3e-1 29 Click to see details
GSE42095 Differentiated embryonic stem cells -0.229 1.5e-1 -0.295 8.6e-2 23 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.225 1.7e-1 0.508 1.1e-2 20 Click to see details
GSE26953 Aortic valvular endothelial cells -0.202 1.7e-1 -0.024 4.6e-1 24 Click to see details
GSE28544 Breast cancer -0.163 2.2e-1 -0.024 4.6e-1 24 Click to see details
GSE14794 Lymphoblastoid cells 0.077 2.4e-1 0.114 1.4e-1 90 Click to see details
GSE17306 Multiple myeloma 0.085 2.8e-1 0.488 1.9e-4 49 Click to see details
GSE27834 Pluripotent stem cells -0.154 2.8e-1 -0.038 4.4e-1 16 Click to see details
GSE38226 Liver fibrosis 0.128 2.9e-1 0.147 2.6e-1 21 Click to see details
GSE21687 Ependynoma primary tumors 0.033 4.0e-1 0.016 4.5e-1 64 Click to see details
GSE21687 Ependynoma primary tumors 0.033 4.0e-1 0.016 4.5e-1 64 Click to see details
GSE21687 Ependynoma primary tumors 0.033 4.0e-1 0.016 4.5e-1 64 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRP 0.508 0 0.388 0.02 31 Click to see details
KICH 0.439 0.02 0.439 0.02 24 Click to see details
THCA -0.252 0.03 -0.224 0.04 59 Click to see details
BRCA -0.183 0.05 -0.155 0.09 79 Click to see details
HNSC 0.238 0.06 0.273 0.04 42 Click to see details
BLCA 0.326 0.1 0.191 0.23 17 Click to see details
LUAD -0.302 0.18 -0.336 0.16 11 Click to see details
CESC -0.72 0.24 -1.000 0.5 3 Click to see details
LIHC 0.099 0.25 0.077 0.3 49 Click to see details
CHOL 0.245 0.26 -0.033 0.47 9 Click to see details
ESCA 0.241 0.27 0.017 0.48 9 Click to see details
PAAD 0.464 0.27 0.000 0.5 4 Click to see details
PRAD 0.074 0.31 0.097 0.26 48 Click to see details
STAD 0.08 0.34 0.060 0.38 29 Click to see details
UCEC -0.068 0.39 0.088 0.36 19 Click to see details
KIRC 0.03 0.41 -0.104 0.2 65 Click to see details
LUSC -0.008 0.48 -0.092 0.29 38 Click to see details
LUSC -0.008 0.48 -0.092 0.29 38 Click to see details
LUSC -0.008 0.48 -0.092 0.29 38 Click to see details
LUSC -0.008 0.48 -0.092 0.29 38 Click to see details
87 hsa-miR-452-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT150000 MIDN midnolin 2 10
MIRT330600 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT358701 SUB1 SUB1 homolog, transcriptional regulator 2 4
MIRT362854 EIF4H eukaryotic translation initiation factor 4H 2 2
MIRT447215 ATXN7 ataxin 7 2 2
MIRT466655 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT483979 PANK1 pantothenate kinase 1 2 8
MIRT485118 SF3B3 splicing factor 3b subunit 3 2 2
MIRT488864 AUTS8 Autism, susceptibility to, 8 2 2
MIRT492293 SH2B3 SH2B adaptor protein 3 2 2
MIRT492976 NCK2 NCK adaptor protein 2 2 2
MIRT497410 LRRC40 leucine rich repeat containing 40 2 2
MIRT511143 MRPL17 mitochondrial ribosomal protein L17 2 6
MIRT512650 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT513017 NSFL1C NSFL1 cofactor 2 6
MIRT520445 TSPAN2 tetraspanin 2 2 6
MIRT527995 NDNF neuron derived neurotrophic factor 2 2
MIRT528667 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT533512 TRIM71 tripartite motif containing 71 2 2
MIRT537404 FBXO47 F-box protein 47 2 2
MIRT538161 DCP2 decapping mRNA 2 2 2
MIRT539124 ARHGEF17 Rho guanine nucleotide exchange factor 17 2 2
MIRT540666 MIS18A MIS18 kinetochore protein A 2 4
MIRT542948 GDF11 growth differentiation factor 11 2 2
MIRT547534 MAML3 mastermind like transcriptional coactivator 3 2 2
MIRT559033 C20orf24 chromosome 20 open reading frame 24 2 4
MIRT559554 ARF6 ADP ribosylation factor 6 2 2
MIRT570177 RCBTB1 RCC1 and BTB domain containing protein 1 2 2
MIRT573149 ITGA9 integrin subunit alpha 9 2 2
MIRT575849 Rab1 RAB1A, member RAS oncogene family 1 1
MIRT611034 RRP1B ribosomal RNA processing 1B 2 2
MIRT616281 HMGB1 high mobility group box 1 2 2
MIRT618372 PRKG2 protein kinase, cGMP-dependent, type II 2 2
MIRT619540 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT622303 SGIP1 SH3 domain GRB2 like endophilin interacting protein 1 2 2
MIRT622590 PRRG4 proline rich and Gla domain 4 2 2
MIRT624441 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT637089 KLRD1 killer cell lectin like receptor D1 2 2
MIRT639084 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT639334 NINJ1 ninjurin 1 2 2
MIRT639798 EIF3E eukaryotic translation initiation factor 3 subunit E 2 2
MIRT640851 RAB3B RAB3B, member RAS oncogene family 2 2
MIRT641628 KIAA1244 ARFGEF family member 3 1 1
MIRT642634 EPPIN epididymal peptidase inhibitor 2 2
MIRT643053 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643416 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT645586 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT647393 FAM181B family with sequence similarity 181 member B 2 2
MIRT649411 CDC14B cell division cycle 14B 2 2
MIRT649477 CLDN16 claudin 16 2 2
MIRT651307 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT651387 ZBTB16 zinc finger and BTB domain containing 16 2 2
MIRT653411 SLC7A2 solute carrier family 7 member 2 2 2
MIRT654084 RSPH4A radial spoke head 4 homolog A 2 2
MIRT654613 PTPRM protein tyrosine phosphatase, receptor type M 2 2
MIRT655338 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT656173 MRPL44 mitochondrial ribosomal protein L44 2 2
MIRT657272 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 2
MIRT657881 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT659875 CAPRIN1 cell cycle associated protein 1 2 2
MIRT662381 ICA1L islet cell autoantigen 1 like 2 4
MIRT666308 SLC22A3 solute carrier family 22 member 3 2 2
MIRT667274 NAV1 neuron navigator 1 2 2
MIRT667614 LIMCH1 LIM and calponin homology domains 1 2 2
MIRT674242 NUP62 nucleoporin 62 2 4
MIRT690386 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT693402 NUDT16 nudix hydrolase 16 2 2
MIRT702503 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT708632 STMN4 stathmin 4 2 2
MIRT708839 SCAND3 zinc finger BED-type containing 9 1 1
MIRT709016 HSBP1 heat shock factor binding protein 1 2 2
MIRT709235 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT710885 PARL presenilin associated rhomboid like 2 2
MIRT712262 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712573 ATP2B4 ATPase plasma membrane Ca2+ transporting 4 2 2
MIRT715046 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT718905 GALR1 galanin receptor 1 2 2
MIRT719368 FEM1A fem-1 homolog A 2 2
MIRT719495 SEC24B SEC24 homolog B, COPII coat complex component 2 2
MIRT719601 PRKX protein kinase, X-linked 2 2
MIRT719891 RRP36 ribosomal RNA processing 36 2 2
MIRT720063 ZNF449 zinc finger protein 449 2 2
MIRT721679 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT721724 VTI1A vesicle transport through interaction with t-SNAREs 1A 2 2
MIRT723370 ZNF470 zinc finger protein 470 2 2
MIRT724941 TXNL1 thioredoxin like 1 2 2
MIRT725302 NLRC5 NLR family CARD domain containing 5 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-452 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-452 Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice liver 20145010 2010 up-regulated
miR-452 Tert-butyl hydroperoxide (t-BHP) NULL 6410 Microarray mouse auditory cells 20510889 2010 down-regulated
miR-452 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CP20)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-mir-452 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-452-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-452-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-452-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (HCT8)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-452-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-452-3p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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