miRTarBase - #MIRT675054


—
pre-miRNA Information
pre-miRNA hsa-mir-1268b   
Genomic Coordinates chr17: 80098828 - 80098877
Description Homo sapiens miR-1268b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1268b
Sequence 4| CGGGCGUGGUGGUGGGGGUG |23
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs565586973 1 dbSNP
rs1007008765 2 dbSNP
rs1405843504 4 dbSNP
rs535896040 5 dbSNP
rs532706583 6 dbSNP
rs1290047771 7 dbSNP
rs1228621577 10 dbSNP
rs1377910066 10 dbSNP
rs1282084939 12 dbSNP
rs1449528405 13 dbSNP
rs148335705 13 dbSNP
rs893367645 16 dbSNP
rs1222208792 18 dbSNP
rs1456165025 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol OR7D2   
Synonyms HTPCRH03, OR19-10, OR19-4
Description olfactory receptor family 7 subfamily D member 2
Transcript NM_175883   
Expression
Putative miRNA Targets on OR7D2
3'UTR of OR7D2
(miRNA target sites are highlighted)		 
>OR7D2|NM_175883|3'UTR
   1 TGGATCCCTTGGCCCCAGGACTAAGAAGTTTTGTGAGCACCAATGGCAAAAATGTTTTATTTTGAAATTCTTACTCTTTA
  81 AAATTAAAAACATTTTTTTATACTTTGAGAGTACAAATGCAGATTTCTTAACATGCATTTGCATAAGGGTGAAGTCTGAG
 161 CTTTTGGCGTACCAATTACCTGAATAGTGAACATAAGGCACTTTTTTTTCTTTTTTGAGACGGAGTCTCACTCTGTCTCC
 241 CAGGCTGGAGTGCAGTGGAGTGATCTCGGCTCACTGCAACCTCCGCCTCCCGGGTTCAAGTGATTCTTCTGTCTCAGCCT
 321 CCTGAGTAGCTGAGATTACAGGTGTGTGCCACCCATGCCTTTTAGTAGAGACGGGGTTTCACCATCTTGGCCAGGCTGGT
 401 CTCGAACTCCTGACCTTGTGATCCACCTGCCTTGGCCTCTCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCCGGC
 481 CAAGGCAGTTTTTAAACTCTCACTCCCCTCTCACCTTTTGCAGTCTCCAGTGTCCATTATTCTGTTATAATGCCCATGCG
 561 TATACATTGTTTAGCTCCCAATTATAAGTGAGATCATGCAGCATTTGACTTTGTTTCTTTACTACCTTACTTAAGAGAAT
 641 GGCTTCCAGTCCCATCGATGTTGCTGCAAAAGACATGATTTCATCCTTTTTTATGGCTGAGTAGTACTCCATTGTATATA
 721 TCCTCGATATCTATATAGATATAGACATATGTAGATACATACCATGTTTTCTTTTTTTAAAAAAATTTATTTTTATGTCA
 801 GTAGTTTTTGGGGTACATGTGGTTTTTCATTACACGGATGAGTTCTTTAGTGGTGACTTCTGAGTTTTTAGTGTACCCGT
 881 CACCCAAGTGGTAGTAGTCTCTTATTCCTCACCCCCCTCCCAACCTTTCTCCCTTCAAGTCACCAAAGTTCATTATATTG
 961 TTCATATCCCTTTGTGTCCTCATAGCTTAGCTCCCACTTATAACTGAGAACATACGATATGTTCATATGGATCTTATGTA
1041 TGTTGGTTGAACATACAAACAAGTCCAGGTTTTTCATTCCTGAGTTACTTCACCTAGAGTAATGACCTCCAGTTCCATCC
1121 AAGTTGCTACAAAAGACATTATTTGGTTCCTTTTTATGGATAAGTAGTATTCCATGCTGTACATATACCACAATCTTTAT
1201 CACTCATTGGTTGATGGGCACTTAGGTTGGTTCCATGCCTTTGTAATTGCTAATTATGTTGCTATAAACATGCAGGTGTA
1281 TGTGTCTTTTTCACATAATGACTTTGTTTCCTTTGGGTAGATACCCAGTAGTGGAACTGCTGGACTGAAAGGTAGTTCTA
1361 CTTTTAGTTCTTTTTTTTGTTTTTTTTTTAAGACAGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGATCTC
1441 ATCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTCCTGCCTCAACCTCCTGAGTAGCTGGGACTACAGGCACCT
1521 GCCACCCCACCCAGCTAATTCTTCTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTG
1601 ACCTCAGGTGATACGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGTGCCTGGCCTTCTAGTTC
1681 TTTAAGATACCACTTTAAAAAAAGTCCAGTCCTCCATTGATGGACACGTAGGTTGATTCCATATCTTTGCTAATGTGAAT
1761 AGTGCCGTGATAAACATGGGGGTGTAAGTTAACAATTAATCTCCAAGTAATTTCCTTGATGGCACTTCTGTCCTATGTGC
1841 TATTCAAAAATTGTGTCCTTGATCATCGTTCTTAATTCTCCATTAGTGAGTTCTGAACTTGGGTTTGAAGCATTTGCTAT
1921 AGCTTTGTTATCTCAAGTGGTGGCACAGAGTTCTTAAGCTATTGATTGTTCACTGACTTTATTTCTATGTGTTTGCATGT
2001 GGGTTTTTGTTGTTTGTGTGTTCGATCATGAACAGATCAACAGTGTTTATTTGTTTTCCTACTGGATGAAGTATGATTAA
2081 AATACGTATTTAAATAT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gugggggUGGUGGUGCGGGc 5'
                 :||||||||||| 
Target 5' ggtgtgaGCCACCACGCCCg 3'
 459 - 478 161.00 -28.60
2 
miRNA  3' guGGGGGUGGUGGUGCGGGc 5'
            ||:| : :: :|||||| 
Target 5' gaCCTCAGGTGATACGCCCa 3'
 1600 - 1619 134.00 -18.90
3 
miRNA  3' gugggGGUGGUGGUGCGGGc 5'
               ||||  |||:|||: 
Target 5' gtgtgCCAC--CCATGCCTt 3'
 344 - 361 123.00 -16.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31492138 7 COSMIC
COSN31510308 12 COSMIC
COSN26987570 19 COSMIC
COSN31491650 20 COSMIC
COSN31605122 26 COSMIC
COSN31580639 28 COSMIC
COSN30508366 39 COSMIC
COSN30470011 46 COSMIC
COSN30124382 64 COSMIC
COSN31594589 69 COSMIC
COSN31514394 100 COSMIC
COSN31582727 116 COSMIC
COSN30541601 161 COSMIC
COSN4968619 170 COSMIC
COSN26643879 193 COSMIC
COSN31553207 199 COSMIC
COSN28850588 210 COSMIC
COSN26647498 211 COSMIC
COSN28882124 211 COSMIC
COSN31533729 233 COSMIC
COSN15625610 289 COSMIC
COSN15625611 387 COSMIC
COSN30510363 416 COSMIC
COSN28652724 479 COSMIC
COSN30534278 497 COSMIC
COSN30173569 526 COSMIC
COSN30129815 527 COSMIC
COSN30130335 560 COSMIC
COSN20324156 566 COSMIC
COSN31547344 638 COSMIC
COSN31565245 658 COSMIC
COSN31590731 662 COSMIC
COSN4968620 683 COSMIC
COSN25478914 692 COSMIC
COSN28668196 704 COSMIC
COSN28712228 723 COSMIC
COSN26101333 764 COSMIC
COSN15625612 778 COSMIC
COSN27546398 778 COSMIC
COSN30534043 779 COSMIC
COSN17769092 780 COSMIC
COSN30132131 786 COSMIC
COSN30112089 797 COSMIC
COSN31603396 814 COSMIC
COSN30128917 846 COSMIC
COSN30133481 879 COSMIC
COSN31552223 879 COSMIC
COSN30544410 880 COSMIC
COSN30142656 939 COSMIC
COSN30135383 951 COSMIC
COSN28726268 969 COSMIC
COSN31537704 1017 COSMIC
COSN30134717 1023 COSMIC
COSN30114131 1136 COSMIC
COSN15625613 1234 COSMIC
COSN30538799 1311 COSMIC
COSN15625614 1312 COSMIC
COSN9853387 1361 COSMIC
COSN30120752 1374 COSMIC
COSN30113965 1379 COSMIC
COSN30135740 1379 COSMIC
COSN30135600 1380 COSMIC
COSN30113032 1389 COSMIC
COSN6553205 1475 COSMIC
COSN8978038 1613 COSMIC
COSN30117135 1615 COSMIC
COSN30138928 1616 COSMIC
COSN8606817 1672 COSMIC
COSN5762755 1684 COSMIC
COSN30131009 1690 COSMIC
COSN24285603 1712 COSMIC
COSN8606818 1741 COSMIC
COSN28705588 1783 COSMIC
COSN15625615 1804 COSMIC
COSN15625616 1815 COSMIC
COSN30158236 1829 COSMIC
COSN30176075 1846 COSMIC
COSN31577724 1854 COSMIC
COSN31557113 1869 COSMIC
COSN30113019 1898 COSMIC
COSN8606819 1902 COSMIC
COSN8553249 1972 COSMIC
COSN21621373 2013 COSMIC
COSN20740432 2025 COSMIC
COSN31529707 2067 COSMIC
COSN30121149 2089 COSMIC
COSN9227087 2094 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1326877831 1 dbSNP
rs775578656 6 dbSNP
rs1454832692 11 dbSNP
rs758729578 12 dbSNP
rs770275188 13 dbSNP
rs1028866636 20 dbSNP
rs1321843945 21 dbSNP
rs1468125030 23 dbSNP
rs780425415 24 dbSNP
rs751184529 31 dbSNP
rs917222535 36 dbSNP
rs953250021 38 dbSNP
rs1198139635 41 dbSNP
rs1480733329 42 dbSNP
rs1251044029 44 dbSNP
rs763301777 48 dbSNP
rs1234432402 52 dbSNP
rs987254447 60 dbSNP
rs1424536268 65 dbSNP
rs577110580 67 dbSNP
rs1231395132 83 dbSNP
rs1369687560 92 dbSNP
rs375591975 92 dbSNP
rs541393424 93 dbSNP
rs560071725 100 dbSNP
rs1394272099 112 dbSNP
rs1297345913 128 dbSNP
rs1435137640 131 dbSNP
rs971809410 137 dbSNP
rs1462813882 143 dbSNP
rs140720391 144 dbSNP
rs981059753 155 dbSNP
rs1417791865 166 dbSNP
rs76235023 170 dbSNP
rs1296583289 172 dbSNP
rs939527963 175 dbSNP
rs1056627341 186 dbSNP
rs747694480 193 dbSNP
rs1343863633 194 dbSNP
rs1279577303 195 dbSNP
rs1315092159 196 dbSNP
rs1306253392 202 dbSNP
rs772315130 202 dbSNP
rs1491053833 209 dbSNP
rs200162898 210 dbSNP
rs772762814 210 dbSNP
rs10423277 211 dbSNP
rs945461862 216 dbSNP
rs1347911118 218 dbSNP
rs1203540731 219 dbSNP
rs1249449596 220 dbSNP
rs1385961532 221 dbSNP
rs1053243449 222 dbSNP
rs549993631 223 dbSNP
rs1363693499 225 dbSNP
rs1183846942 227 dbSNP
rs1009130159 228 dbSNP
rs1189328742 229 dbSNP
rs867344941 234 dbSNP
rs571504152 239 dbSNP
rs1043778743 241 dbSNP
rs1187701550 244 dbSNP
rs1441436660 245 dbSNP
rs1339183040 246 dbSNP
rs1019221027 249 dbSNP
rs965017385 250 dbSNP
rs550916036 257 dbSNP
rs996224365 258 dbSNP
rs867942139 259 dbSNP
rs1347988026 260 dbSNP
rs1027361042 261 dbSNP
rs1267415582 262 dbSNP
rs538915409 268 dbSNP
rs1028897628 269 dbSNP
rs1291147985 273 dbSNP
rs983225698 279 dbSNP
rs547349008 285 dbSNP
rs867200919 286 dbSNP
rs1380578957 288 dbSNP
rs1384419318 289 dbSNP
rs565984346 292 dbSNP
rs1353156253 293 dbSNP
rs10402805 303 dbSNP
rs1164616681 306 dbSNP
rs1475969147 316 dbSNP
rs1336995711 338 dbSNP
rs772640389 340 dbSNP
rs916479892 354 dbSNP
rs776012765 357 dbSNP
rs552857025 358 dbSNP
rs76585702 359 dbSNP
rs1299247851 360 dbSNP
rs147562473 369 dbSNP
rs558709510 373 dbSNP
rs149187864 374 dbSNP
rs181120027 375 dbSNP
rs147582060 377 dbSNP
rs541632492 390 dbSNP
rs551806906 404 dbSNP
rs776546203 405 dbSNP
rs980419779 415 dbSNP
rs1364752607 416 dbSNP
rs1326605510 417 dbSNP
rs1443236158 417 dbSNP
rs559761638 422 dbSNP
rs1325886973 426 dbSNP
rs926884979 446 dbSNP
rs939598143 454 dbSNP
rs1205737127 462 dbSNP
rs1263987572 465 dbSNP
rs1461087627 468 dbSNP
rs1166519792 469 dbSNP
rs552313664 472 dbSNP
rs575080544 474 dbSNP
rs565843253 475 dbSNP
rs900747208 476 dbSNP
rs1283423767 477 dbSNP
rs7246654 479 dbSNP
rs1438178460 486 dbSNP
rs1274787837 498 dbSNP
rs1044235291 502 dbSNP
rs903936628 511 dbSNP
rs1027695627 516 dbSNP
rs951766199 517 dbSNP
rs1417744197 528 dbSNP
rs932679955 532 dbSNP
rs1177685108 535 dbSNP
rs554588574 536 dbSNP
rs1014616952 537 dbSNP
rs1467952386 549 dbSNP
rs891095502 554 dbSNP
rs758507309 555 dbSNP
rs1429542063 557 dbSNP
rs1008775556 560 dbSNP
rs541447559 561 dbSNP
rs991951403 566 dbSNP
rs1190141578 567 dbSNP
rs1470444633 567 dbSNP
rs897689680 570 dbSNP
rs1202142722 576 dbSNP
rs993336681 580 dbSNP
rs916452726 582 dbSNP
rs867498160 583 dbSNP
rs1213378342 584 dbSNP
rs951756237 587 dbSNP
rs979374282 595 dbSNP
rs1369727324 598 dbSNP
rs1223886568 607 dbSNP
rs764342710 612 dbSNP
rs1277930032 614 dbSNP
rs1224425272 617 dbSNP
rs1376112565 618 dbSNP
rs925922360 623 dbSNP
rs1282456572 625 dbSNP
rs1001929661 627 dbSNP
rs1440571912 630 dbSNP
rs936028524 638 dbSNP
rs988839472 650 dbSNP
rs566621313 657 dbSNP
rs773039713 658 dbSNP
rs1436122896 665 dbSNP
rs1286373993 668 dbSNP
rs1447671031 671 dbSNP
rs184897697 673 dbSNP
rs762676365 676 dbSNP
rs757394245 681 dbSNP
rs932203802 682 dbSNP
rs80252081 683 dbSNP
rs888057651 693 dbSNP
rs914150976 694 dbSNP
rs1004489425 695 dbSNP
rs138411955 700 dbSNP
rs1257888234 703 dbSNP
rs574480386 708 dbSNP
rs565786042 709 dbSNP
rs896234709 713 dbSNP
rs1013298331 714 dbSNP
rs1479227461 719 dbSNP
rs1023852101 726 dbSNP
rs1408000765 727 dbSNP
rs969266461 740 dbSNP
rs1399614993 743 dbSNP
rs979608339 749 dbSNP
rs979727952 751 dbSNP
rs925433975 753 dbSNP
rs932753493 758 dbSNP
rs1032244888 763 dbSNP
rs1376479683 767 dbSNP
rs201359716 772 dbSNP
rs150569100 778 dbSNP
rs373303750 778 dbSNP
rs779375513 778 dbSNP
rs397805173 779 dbSNP
rs532703514 779 dbSNP
rs55913502 779 dbSNP
rs56165015 779 dbSNP
rs548283105 780 dbSNP
rs913269901 785 dbSNP
rs569750792 787 dbSNP
rs1281497127 794 dbSNP
rs1421874828 800 dbSNP
rs141711871 805 dbSNP
rs189882365 811 dbSNP
rs976212585 813 dbSNP
rs922066163 818 dbSNP
rs932157289 821 dbSNP
rs376369497 822 dbSNP
rs1223278898 830 dbSNP
rs558599911 834 dbSNP
rs77698070 836 dbSNP
rs940982745 837 dbSNP
rs1223919000 851 dbSNP
rs1291431335 854 dbSNP
rs1489964811 862 dbSNP
rs781781303 866 dbSNP
rs1183448157 872 dbSNP
rs549327390 879 dbSNP
rs534859044 880 dbSNP
rs1174944092 887 dbSNP
rs1001957551 889 dbSNP
rs1013264311 893 dbSNP
rs1327896874 898 dbSNP
rs1456186300 902 dbSNP
rs1367745639 912 dbSNP
rs553578289 912 dbSNP
rs1162868089 913 dbSNP
rs1363414313 914 dbSNP
rs1430463136 917 dbSNP
rs1431392921 918 dbSNP
rs1023394702 926 dbSNP
rs1208653774 928 dbSNP
rs1488445583 939 dbSNP
rs1033426586 947 dbSNP
rs561752954 956 dbSNP
rs1207096664 959 dbSNP
rs542543317 964 dbSNP
rs6511918 969 dbSNP
rs1226993169 983 dbSNP
rs576076953 997 dbSNP
rs1305530166 1004 dbSNP
rs1021650996 1005 dbSNP
rs1389938141 1006 dbSNP
rs1032629027 1009 dbSNP
rs1277807124 1011 dbSNP
rs1385110436 1013 dbSNP
rs1368925574 1014 dbSNP
rs956601443 1016 dbSNP
rs988063576 1017 dbSNP
rs1196868890 1018 dbSNP
rs1291694956 1019 dbSNP
rs1020255978 1027 dbSNP
rs543455140 1028 dbSNP
rs966048914 1038 dbSNP
rs78667112 1042 dbSNP
rs1482305966 1044 dbSNP
rs771672426 1052 dbSNP
rs1272020144 1053 dbSNP
rs1204080422 1054 dbSNP
rs1281768767 1056 dbSNP
rs1348160679 1056 dbSNP
rs922021536 1061 dbSNP
rs1330419898 1062 dbSNP
rs1307680359 1063 dbSNP
rs953627550 1067 dbSNP
rs1307189926 1070 dbSNP
rs1348472826 1070 dbSNP
rs1436827268 1081 dbSNP
rs1377529283 1091 dbSNP
rs1202033148 1098 dbSNP
rs1465639765 1100 dbSNP
rs985546878 1100 dbSNP
rs912636563 1103 dbSNP
rs944065959 1104 dbSNP
rs984971734 1116 dbSNP
rs117675376 1117 dbSNP
rs1383288511 1119 dbSNP
rs7247330 1128 dbSNP
rs540868245 1135 dbSNP
rs546097616 1144 dbSNP
rs559859068 1146 dbSNP
rs1257872263 1147 dbSNP
rs557279819 1157 dbSNP
rs746588564 1165 dbSNP
rs937819745 1170 dbSNP
rs1261236878 1172 dbSNP
rs1230084544 1173 dbSNP
rs1327114078 1175 dbSNP
rs1054910597 1192 dbSNP
rs1287437662 1193 dbSNP
rs1415205794 1194 dbSNP
rs896220894 1200 dbSNP
rs1332495496 1210 dbSNP
rs182046230 1216 dbSNP
rs149241045 1219 dbSNP
rs949041232 1223 dbSNP
rs368963114 1226 dbSNP
rs1020632978 1227 dbSNP
rs1453464742 1227 dbSNP
rs770365653 1240 dbSNP
rs1314521949 1250 dbSNP
rs902144139 1251 dbSNP
rs770245150 1252 dbSNP
rs1476420212 1254 dbSNP
rs1369826324 1255 dbSNP
rs1185047401 1257 dbSNP
rs1230304345 1271 dbSNP
rs1441491380 1279 dbSNP
rs776566719 1281 dbSNP
rs1261746793 1287 dbSNP
rs1271092343 1306 dbSNP
rs1001125083 1316 dbSNP
rs1032551730 1321 dbSNP
rs1001056235 1322 dbSNP
rs1233649694 1327 dbSNP
rs954242919 1341 dbSNP
rs1282634191 1344 dbSNP
rs573461723 1352 dbSNP
rs530780617 1353 dbSNP
rs1322581221 1354 dbSNP
rs1009460244 1364 dbSNP
rs1388506088 1366 dbSNP
rs1327233497 1370 dbSNP
rs965509402 1371 dbSNP
rs973198372 1371 dbSNP
rs1472234734 1380 dbSNP
rs918602605 1380 dbSNP
rs931304441 1383 dbSNP
rs1019530352 1386 dbSNP
rs965312865 1391 dbSNP
rs984740265 1401 dbSNP
rs909116379 1407 dbSNP
rs1247324746 1409 dbSNP
rs1214314176 1416 dbSNP
rs1448621787 1420 dbSNP
rs1193832034 1425 dbSNP
rs542538299 1429 dbSNP
rs1209044427 1432 dbSNP
rs143513115 1433 dbSNP
rs535159923 1434 dbSNP
rs1431690261 1435 dbSNP
rs1470450128 1436 dbSNP
rs1439154679 1439 dbSNP
rs1336121468 1443 dbSNP
rs1348673383 1447 dbSNP
rs985284744 1448 dbSNP
rs775186026 1452 dbSNP
rs1319564329 1454 dbSNP
rs1326427126 1455 dbSNP
rs1429049047 1460 dbSNP
rs530411147 1466 dbSNP
rs762783559 1467 dbSNP
rs972232547 1474 dbSNP
rs1388938192 1475 dbSNP
rs918148839 1476 dbSNP
rs1197863473 1477 dbSNP
rs1438231293 1478 dbSNP
rs1277032588 1492 dbSNP
rs529692659 1493 dbSNP
rs372230385 1502 dbSNP
rs757416484 1504 dbSNP
rs1281069508 1517 dbSNP
rs902214121 1518 dbSNP
rs926290000 1519 dbSNP
rs1260650672 1524 dbSNP
rs1443374698 1525 dbSNP
rs1352229873 1530 dbSNP
rs1306562374 1531 dbSNP
rs1407549349 1532 dbSNP
rs1369580667 1533 dbSNP
rs1176106392 1537 dbSNP
rs1415720988 1539 dbSNP
rs1422947309 1542 dbSNP
rs1171995290 1548 dbSNP
rs1470474730 1551 dbSNP
rs1253636221 1554 dbSNP
rs1179776793 1557 dbSNP
rs553274919 1560 dbSNP
rs1258538480 1561 dbSNP
rs568665594 1561 dbSNP
rs1053551650 1562 dbSNP
rs1278525855 1574 dbSNP
rs535690437 1575 dbSNP
rs1331853606 1580 dbSNP
rs1286790720 1587 dbSNP
rs1409632071 1599 dbSNP
rs543414056 1615 dbSNP
rs892251006 1616 dbSNP
rs890017685 1617 dbSNP
rs1269376401 1620 dbSNP
rs186880065 1624 dbSNP
rs1040939665 1625 dbSNP
rs1019792147 1626 dbSNP
rs1472172122 1628 dbSNP
rs1455408732 1632 dbSNP
rs1183891228 1633 dbSNP
rs965895065 1639 dbSNP
rs901082991 1648 dbSNP
rs972882005 1663 dbSNP
rs78613335 1665 dbSNP
rs77851541 1666 dbSNP
rs984104257 1668 dbSNP
rs1335990968 1671 dbSNP
rs953523875 1672 dbSNP
rs1229620267 1675 dbSNP
rs959291222 1681 dbSNP
rs374582801 1687 dbSNP
rs1283048271 1697 dbSNP
rs558634577 1698 dbSNP
rs1435241343 1705 dbSNP
rs563386676 1710 dbSNP
rs1016287527 1718 dbSNP
rs1403890358 1727 dbSNP
rs576857353 1728 dbSNP
rs1298745856 1729 dbSNP
rs1337231320 1742 dbSNP
rs114963504 1757 dbSNP
rs1422232257 1760 dbSNP
rs1042171072 1763 dbSNP
rs1025130281 1765 dbSNP
rs147194999 1767 dbSNP
rs981433024 1768 dbSNP
rs796874481 1781 dbSNP
rs1348407446 1782 dbSNP
rs140457245 1783 dbSNP
rs936321883 1784 dbSNP
rs1490127722 1794 dbSNP
rs767646252 1797 dbSNP
rs867914191 1801 dbSNP
rs557891742 1807 dbSNP
rs1219867784 1813 dbSNP
rs945142464 1817 dbSNP
rs1040868273 1836 dbSNP
rs1228482628 1867 dbSNP
rs868177984 1868 dbSNP
rs901006806 1869 dbSNP
rs1182577624 1883 dbSNP
rs1294778876 1908 dbSNP
rs769063464 1913 dbSNP
rs1295026073 1925 dbSNP
rs541639314 1939 dbSNP
rs1166027531 1950 dbSNP
rs1366512645 1959 dbSNP
rs1169526099 1965 dbSNP
rs1424417304 1972 dbSNP
rs563202510 1973 dbSNP
rs1398156396 1974 dbSNP
rs1034360871 1978 dbSNP
rs888396470 1988 dbSNP
rs750987355 1990 dbSNP
rs1189822816 1996 dbSNP
rs1488394142 1998 dbSNP
rs1374034791 2002 dbSNP
rs1290577867 2008 dbSNP
rs958658281 2011 dbSNP
rs756621519 2024 dbSNP
rs867017989 2025 dbSNP
rs530760516 2029 dbSNP
rs990789470 2030 dbSNP
rs993550596 2031 dbSNP
rs1303380014 2032 dbSNP
rs1366729425 2034 dbSNP
rs77993015 2037 dbSNP
rs1411848062 2045 dbSNP
rs1219952046 2046 dbSNP
rs1168006399 2047 dbSNP
rs1466661197 2059 dbSNP
rs1379870200 2061 dbSNP
rs1252893093 2068 dbSNP
rs970613165 2070 dbSNP
rs1252923977 2074 dbSNP
rs1196621483 2080 dbSNP
rs978308157 2086 dbSNP
rs570858415 2087 dbSNP
rs971320848 2088 dbSNP
rs528554555 2097 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' guggggguggUGGUGcgggc 5'
                    :||||     
Target 5' acaggugugaGCCACc---- 3'
 		18 - 33
2 
miRNA  3' gugggggugguggUGCGGgc 5'
                       ::||:  
Target 5' -------cucaaaGUGCUgg 3'
 		1 - 13
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_175883 | 3UTR | CAGGCUGGUCUUGAACUCCUGACCUCAGGUGAUACGCCCACCUCGGCCUCCCAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_175883 | 3UTR | CCUCAGGUGAUACGCCCACCUCGGCCUCCCAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_175883 | 3UTR | UGGUCUUGAACUCCUGACCUCAGGUGAUACGCCCACCUCGGCCUCCCAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_175883 | 3UTR | CCUCAGGUGAUACGCCCACCUCGGCCUCCCAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_175883 | 3UTR | UCUUGAACUCCUGACCUCAGGUGAUACGCCCACCUCGGCCUCCCAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000344248.2 | 3UTR | CUCAAAGUGCUGGGAUUACAGGUGUGAGCCACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
40 hsa-miR-1268b Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT473716 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT483653 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT484276 AIP aryl hydrocarbon receptor interacting protein 2 4
MIRT486673 WDR81 WD repeat domain 81 2 2
MIRT488670 WWP2 WW domain containing E3 ubiquitin protein ligase 2 2 4
MIRT493452 ITFG3 family with sequence similarity 234 member A 2 2
MIRT495901 ZNF641 zinc finger protein 641 2 2
MIRT500187 BARX1 BARX homeobox 1 2 4
MIRT512014 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT521132 SGPL1 sphingosine-1-phosphate lyase 1 2 4
MIRT530046 TRIM72 tripartite motif containing 72 2 2
MIRT531518 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT543735 DHCR7 7-dehydrocholesterol reductase 2 2
MIRT558053 EVI5L ecotropic viral integration site 5 like 2 2
MIRT569602 TRIM29 tripartite motif containing 29 2 2
MIRT570025 FAM228A family with sequence similarity 228 member A 2 2
MIRT573593 CERS1 ceramide synthase 1 2 2
MIRT623883 FRMPD4 FERM and PDZ domain containing 4 2 2
MIRT629999 PDE6B phosphodiesterase 6B 2 2
MIRT632715 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT633496 ERO1L endoplasmic reticulum oxidoreductase 1 alpha 1 1
MIRT637075 SELPLG selectin P ligand 2 2
MIRT638182 TLN1 talin 1 2 2
MIRT638766 EPB41 erythrocyte membrane protein band 4.1 2 2
MIRT668072 GMPS guanine monophosphate synthase 2 2
MIRT669873 RAET1E retinoic acid early transcript 1E 2 2
MIRT670663 KIAA1551 KIAA1551 2 2
MIRT671282 RPL37A ribosomal protein L37a 2 2
MIRT675054 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT682783 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 2
MIRT683343 SCARF1 scavenger receptor class F member 1 2 2
MIRT690282 ZNF154 zinc finger protein 154 2 2
MIRT695171 SLC25A33 solute carrier family 25 member 33 2 2
MIRT695221 SCAMP3 secretory carrier membrane protein 3 2 2
MIRT700484 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700600 PRKCA protein kinase C alpha 2 2
MIRT701409 NKRF NFKB repressing factor 2 2
MIRT703994 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT711231 RETSAT retinol saturase 2 2
MIRT719509 TMEM175 transmembrane protein 175 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1268b Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved resistant High Pancreatic Cancer cell line (BxPC-3)
hsa-miR-1268b Doxorubicin 31703 NSC123127 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-1268b Cytoxan + Pirarubicin + Fluorouracil sensitive High Breast Cancer tissue
hsa-miR-1268b Cytoxan + Doxorubicin + Fluorouracil sensitive High Breast Cancer tissue
hsa-miR-1268b Cytoxan + Epirubicin + Fluorouracil sensitive High Breast Cancer tissue
hsa-miR-1268b Doxorubicin + Taxol sensitive High Breast Cancer tissue
hsa-miR-1268b Erlotinib 176870 NSC718781 approved resistant High Head And Neck Squamous Cell Carcinoma cell line (HN6)
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-1268b Anthracycline 30323 NSC82151 approved sensitive High Breast Cancer tissue
hsa-miR-1268b Cyclophosphamide 2907 NSC26271 approved sensitive High Breast Cancer tissue
hsa-miR-1268b Fluorouracil 3385 NSC19893 approved sensitive High Breast Cancer tissue
hsa-miR-1268b Taxol 36314 NSC125973 approved sensitive High Breast Cancer tissue
hsa-miR-1268b Methotrexate 126941 NSC740 approved sensitive High Breast Cancer tissue
hsa-miR-1268b Doxorubicin 31703 NSC123127 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268b Paclitaxel 36314 NSC125973 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268b Etoposide 36462 NSC141540 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268b Vinorelbine 44424639 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268b Vincristine 5978 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-mir-1268b Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-1268b Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-1268b Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-1268b Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved resistant cell line (MDAH-2774)
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)

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