pre-miRNA Information
pre-miRNA hsa-mir-4680   
Genomic Coordinates chr10: 110898090 - 110898155
Description Homo sapiens miR-4680 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4680-5p
Sequence 5| AGAACUCUUGCAGUCUUAGAUGU |27
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1274530692 2 dbSNP
rs780271274 5 dbSNP
rs1461423681 7 dbSNP
rs749729920 8 dbSNP
rs1252920446 10 dbSNP
rs201739274 11 dbSNP
rs774971106 19 dbSNP
rs748132091 22 dbSNP
rs773643180 22 dbSNP
rs1235425484 23 dbSNP
Putative Targets

Gene Information
Gene Symbol NUBPL   
Synonyms C14orf127, IND1, huInd1
Description nucleotide binding protein like
Transcript NM_025152   
Expression
Putative miRNA Targets on NUBPL
3'UTR of NUBPL
(miRNA target sites are highlighted)
>NUBPL|NM_025152|3'UTR
   1 TTCCCCAAGTGTCCTGGAAATTTGCCTGGTACTGACATTAAGAGGACCTTTGGAAATCAGCAATGTGGTGATGGAACCTA
  81 CAGAAATAATAGAAATCATAACTGTTTTATTTCTAAGGAAAGAATGTCTTCATATTTGACTTGCTAAGCTAAGGTTCACA
 161 AAACTTTGATGTATCAATGTTAACTGCTATATTTAGGAATTTTTTGAAAGCTGGTGTGTACCACCTGCAAAGAACTGCAT
 241 TTTATTTTATTGAATTACCCCTTTAGAAATCACGAGTTTATGATGTTACAAGTCCATTTTGGGAGAGAACTGTACACTTT
 321 TTGCAGGACCACAGAATTAGTAATTTAAATGATATACTAAATTTGTGTATGGGCATAAGTATTACGCCTTCCCACCAGGC
 401 AATTTGGACTGTCTTTGAATCCTGTCTTTGGTACTGTCTTGGACATGTTCTTAATATGAACCTCTGCTTCTTCATCTGGA
 481 TCACACTATACCCCAGACTTAATGAATTTCAGTCTCCAGGAGTGGAGCCTGAACATATGTATTTTTAGTAAGACCATGAT
 561 GATGTTGATGATGATTCTGGTAATCATGGCAGTAAGAATAATAGCTAACATTTAACAAGTTAATTATAATTGTTCTTCCA
 641 TTTGTGTGAGTGGGTACTATTATCTCCATTTTACAGATAAGTAATTTGAGATATAATTTGAAGGCACTCAACCTTGAGTG
 721 TCTTGCTGAGGGTTACTGTATCTAGCAGGTGATGGAGCTTGGATTTGAACTTGAGTAATTCGATATTAGATTCATCTTTT
 801 TGTACACCAATGTGCTTTTGTTAATTAAAAAAAGTCGGTGGTGGCTAGGCGTGGTGGCTCACGCCTGTAATCCCAGCACT
 881 TTGGGAGGTTGAGGTGGGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACT
 961 AAAAATACAAAAATTAGCTGGGTGTGGTGGCATATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCATT
1041 TCAACCCGGGAGGCTGAGGTTGCAGTGAGTGGAGATTGTACCACTGCACTCCAGCCTGGTCAATGGAGTGCGACTCCATC
1121 TCAAAAAAAAAAAAAAAAAAAAAAAAAGTCGGGGGAGATGCAATATTTAGCATTTCCTCAAACTTTTTTTGGCCATGAAA
1201 TCCACCACCCCCCTCCTTTTTCAGAGCATTTCATGAAGTTCACATTTCAAATAATACATTTTGAAAAACATTTATCTTGT
1281 CTAATTGAAGCTCAAAGAGATAGAGTCAATGACTTTTCAAAGTCAGGTAGCAGATAGTTTTAAAGCTGCAAGTACTGATA
1361 AGTGTGAGCCATTAGTTAATTCGCATTTATAAAGAAGTGGTCTGTCACTTTTGGCAAATGTCTTGACATCTGTTGCTCTA
1441 CAGTTGTCAACTAGAAAATTAGGCATAGAGTTTCACATTATTATAAGCATGTTTTCACACAAAAACATGTACATTGATGT
1521 TTATTGCAATTTTATGTGTAATAACCAAAAACAACCCAGATTTTCTTCATTGGGTAAATGATTAAACAAACCATAGTACA
1601 TTCATACCGTGAGTGCTACTCAGCAATAAAAAAGAACAAACTATGGGTACAGGCAGCAACTTATAATTCCAGAGAATTAT
1681 GCTGAATGAAAAAGGCCAATTTAAAAAGGTTTTGTACCAAAAGATTCCATTTATATAACGTTCTTGAAGTGACATAATTA
1761 TAGAAATGGAGAACAGATTAGTGGTGGCTGTGTTAAGGAGGGGGTGAGGATGGGAGAGAATTGGGCGTGGCTGTGAGAAA
1841 CATGAGGGATCCTTGTGATGATGGAAATGTTCTATATCACAGCTATCGATGTCAGTATCCCAGTTGTGATATTGTGCTAT
1921 AGTTTTGCAAGATGTTACCACTGGGGGAAATTGGGTGAAGGGCACATGGAATCTCTGTATTATTTCAACTGCATGTAAAT
2001 CTACAATTATCTCAAAATAAAAATAAAAGTTAAAAAAACACAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugUAG-AUUCUGACGUUCUCAAGa 5'
            ||| |:||::  ||:|||||| 
Target 5' ggATCATGAGGT--CAGGAGTTCa 3'
900 - 921 149.00 -14.90
2
miRNA  3' ugUAGA--UUCUGA--CGU-UCUCAAGa 5'
            | ||  || |:|  ||| ||||||: 
Target 5' tcAACTAGAAAATTAGGCATAGAGTTTc 3'
1447 - 1474 141.00 -9.50
3
miRNA  3' ugUAGAUUCUGACGUUCUCAaga 5'
            ||:| || || ||:||||   
Target 5' gaATTTCAGTCTCCAGGAGTgga 3'
504 - 526 121.00 -10.42
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
883616 27 ClinVar
881257 73 ClinVar
313032 123 ClinVar
313033 136 ClinVar
313034 189 ClinVar
881258 238 ClinVar
313035 274 ClinVar
881259 302 ClinVar
313036 313 ClinVar
881718 324 ClinVar
881719 345 ClinVar
313037 356 ClinVar
313038 358 ClinVar
313039 445 ClinVar
313040 528 ClinVar
313041 537 ClinVar
313042 562 ClinVar
313043 639 ClinVar
882868 737 ClinVar
882869 743 ClinVar
882870 807 ClinVar
882871 818 ClinVar
313044 837 ClinVar
882872 851 ClinVar
882873 865 ClinVar
313045 906 ClinVar
313046 996 ClinVar
313047 1016 ClinVar
883661 1048 ClinVar
313048 1049 ClinVar
313049 1054 ClinVar
313050 1120 ClinVar
313051 1121 ClinVar
313052 1121 ClinVar
313053 1122 ClinVar
313054 1122 ClinVar
313055 1123 ClinVar
313056 1123 ClinVar
313057 1145 ClinVar
313058 1146 ClinVar
313059 1148 ClinVar
313060 1150 ClinVar
313061 1151 ClinVar
313062 1152 ClinVar
313063 1261 ClinVar
883662 1371 ClinVar
313064 1452 ClinVar
881319 1555 ClinVar
881320 1595 ClinVar
313065 1610 ClinVar
313066 1620 ClinVar
881321 1622 ClinVar
881322 1656 ClinVar
313067 1686 ClinVar
313068 1695 ClinVar
881766 1769 ClinVar
313069 1774 ClinVar
313070 1777 ClinVar
313071 1841 ClinVar
313072 1875 ClinVar
313073 1889 ClinVar
881767 1941 ClinVar
882915 1964 ClinVar
313074 2037 ClinVar
COSN30473531 6 COSMIC
COSN30137479 14 COSMIC
COSN31494035 29 COSMIC
COSN16127608 43 COSMIC
COSN30112976 114 COSMIC
COSN6636668 123 COSMIC
COSN30132555 156 COSMIC
COSN9612367 158 COSMIC
COSN31960970 386 COSMIC
COSN26341712 737 COSMIC
COSN20868280 1628 COSMIC
COSN26745436 1757 COSMIC
COSN16415063 1780 COSMIC
COSN19346042 1835 COSMIC
COSN6411537 1910 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs763286360 4 dbSNP
rs1161041441 7 dbSNP
rs531163679 9 dbSNP
rs774778951 10 dbSNP
rs759901062 15 dbSNP
rs1294149229 21 dbSNP
rs1399611401 26 dbSNP
rs76130953 27 dbSNP
rs752198195 29 dbSNP
rs1360811554 33 dbSNP
rs1434370807 37 dbSNP
rs1319937185 38 dbSNP
rs570611473 40 dbSNP
rs763617355 41 dbSNP
rs1282575951 43 dbSNP
rs1355927609 47 dbSNP
rs753449669 48 dbSNP
rs914698510 49 dbSNP
rs756909464 53 dbSNP
rs947485631 54 dbSNP
rs982029774 57 dbSNP
rs1298376021 64 dbSNP
rs975175643 73 dbSNP
rs1427760302 76 dbSNP
rs1419066783 77 dbSNP
rs1035907212 82 dbSNP
rs1462663375 90 dbSNP
rs961971580 93 dbSNP
rs972384429 98 dbSNP
rs534720808 102 dbSNP
rs1203547694 103 dbSNP
rs1458583199 116 dbSNP
rs4981131 123 dbSNP
rs933584560 133 dbSNP
rs1339376273 134 dbSNP
rs377738028 136 dbSNP
rs908052677 139 dbSNP
rs1280880295 156 dbSNP
rs1379882684 162 dbSNP
rs535363364 172 dbSNP
rs940802519 178 dbSNP
rs569141248 189 dbSNP
rs575083611 207 dbSNP
rs539292817 208 dbSNP
rs1264084621 215 dbSNP
rs1296445904 216 dbSNP
rs770243224 219 dbSNP
rs1350267146 221 dbSNP
rs1165686964 225 dbSNP
rs1489388794 230 dbSNP
rs371415587 240 dbSNP
rs943854176 249 dbSNP
rs898950992 253 dbSNP
rs1262171212 258 dbSNP
rs1478337908 259 dbSNP
rs1174207609 260 dbSNP
rs557533136 265 dbSNP
rs76188062 274 dbSNP
rs1045154118 275 dbSNP
rs1158879915 283 dbSNP
rs1362139167 291 dbSNP
rs1480480173 296 dbSNP
rs1266430797 301 dbSNP
rs189475622 302 dbSNP
rs1356793672 308 dbSNP
rs1296791216 310 dbSNP
rs10162516 313 dbSNP
rs1240231585 314 dbSNP
rs1337017209 330 dbSNP
rs192984391 331 dbSNP
rs1390769531 332 dbSNP
rs572496732 345 dbSNP
rs564011307 352 dbSNP
rs1010728157 353 dbSNP
rs886050452 356 dbSNP
rs540433502 357 dbSNP
rs576520205 358 dbSNP
rs1163254093 367 dbSNP
rs1420316774 368 dbSNP
rs1365622201 371 dbSNP
rs531127178 372 dbSNP
rs1036303551 376 dbSNP
rs1233743360 384 dbSNP
rs961636545 386 dbSNP
rs552760300 387 dbSNP
rs921938454 398 dbSNP
rs1027261459 401 dbSNP
rs564681074 403 dbSNP
rs1356179942 407 dbSNP
rs987728348 413 dbSNP
rs1352153623 427 dbSNP
rs1258466031 435 dbSNP
rs774768075 438 dbSNP
rs952331223 443 dbSNP
rs10162515 445 dbSNP
rs1344643779 458 dbSNP
rs1302723974 467 dbSNP
rs1451915987 470 dbSNP
rs1200929152 473 dbSNP
rs1244840853 474 dbSNP
rs910936065 483 dbSNP
rs1156864519 484 dbSNP
rs1477655101 487 dbSNP
rs1037903540 489 dbSNP
rs1178776428 492 dbSNP
rs965540648 495 dbSNP
rs184174410 497 dbSNP
rs1179211841 498 dbSNP
rs1479625649 499 dbSNP
rs1417527170 511 dbSNP
rs1193881122 524 dbSNP
rs866511241 526 dbSNP
rs560274677 528 dbSNP
rs1044792814 535 dbSNP
rs1259293983 537 dbSNP
rs200626091 537 dbSNP
rs886050453 537 dbSNP
rs771807640 539 dbSNP
rs1003249985 540 dbSNP
rs1053607572 541 dbSNP
rs1278645125 554 dbSNP
rs1229395002 556 dbSNP
rs1052043206 557 dbSNP
rs189555353 562 dbSNP
rs1381648814 563 dbSNP
rs1325932591 565 dbSNP
rs1010757835 579 dbSNP
rs1468731397 588 dbSNP
rs1440786879 589 dbSNP
rs1029013651 593 dbSNP
rs1171802972 593 dbSNP
rs1370982606 595 dbSNP
rs1192032262 603 dbSNP
rs138352548 619 dbSNP
rs1442436386 624 dbSNP
rs1022100246 627 dbSNP
rs963881352 631 dbSNP
rs1201649795 633 dbSNP
rs886050454 639 dbSNP
rs1379155188 640 dbSNP
rs1258691298 651 dbSNP
rs1238273975 662 dbSNP
rs149637866 663 dbSNP
rs1260303831 678 dbSNP
rs996670363 688 dbSNP
rs1029041920 693 dbSNP
rs954958491 699 dbSNP
rs539356568 702 dbSNP
rs1211487866 705 dbSNP
rs557494401 708 dbSNP
rs573903450 709 dbSNP
rs1044831381 731 dbSNP
rs111321293 737 dbSNP
rs1405979481 739 dbSNP
rs1468017671 741 dbSNP
rs760265792 743 dbSNP
rs1057282894 760 dbSNP
rs962314284 763 dbSNP
rs534787456 783 dbSNP
rs920774147 785 dbSNP
rs948212811 787 dbSNP
rs994352987 793 dbSNP
rs981345890 794 dbSNP
rs139044047 807 dbSNP
rs1181192464 810 dbSNP
rs1177644520 811 dbSNP
rs1368621018 827 dbSNP
rs939090000 828 dbSNP
rs10147479 837 dbSNP
rs542291059 838 dbSNP
rs1461405255 841 dbSNP
rs557397654 842 dbSNP
rs1360408340 843 dbSNP
rs757233843 844 dbSNP
rs575971569 850 dbSNP
rs370650416 851 dbSNP
rs1402562635 852 dbSNP
rs1280590330 853 dbSNP
rs1043587702 858 dbSNP
rs1445019687 861 dbSNP
rs532251946 863 dbSNP
rs1306379777 864 dbSNP
rs996734164 865 dbSNP
rs765110647 866 dbSNP
rs923731189 868 dbSNP
rs1178835635 888 dbSNP
rs1333833119 893 dbSNP
rs1232281248 894 dbSNP
rs890576087 898 dbSNP
rs1008969470 902 dbSNP
rs865828752 904 dbSNP
rs750277296 906 dbSNP
rs1220554817 910 dbSNP
rs1358757879 912 dbSNP
rs962011047 916 dbSNP
rs1456075637 931 dbSNP
rs1225580966 936 dbSNP
rs1349137231 940 dbSNP
rs973660068 952 dbSNP
rs564578377 953 dbSNP
rs373950021 960 dbSNP
rs915120620 961 dbSNP
rs970036751 973 dbSNP
rs1184905343 992 dbSNP
rs144052980 993 dbSNP
rs10136892 996 dbSNP
rs1172015723 1001 dbSNP
rs939121096 1008 dbSNP
rs1266538709 1015 dbSNP
rs551958784 1016 dbSNP
rs1297731665 1017 dbSNP
rs1402964694 1026 dbSNP
rs1218028482 1030 dbSNP
rs913575962 1048 dbSNP
rs886050455 1049 dbSNP
rs546991443 1054 dbSNP
rs1326045636 1059 dbSNP
rs899784209 1064 dbSNP
rs1218948427 1068 dbSNP
rs1223330450 1069 dbSNP
rs528956467 1083 dbSNP
rs1362205886 1093 dbSNP
rs112276151 1101 dbSNP
rs932549558 1104 dbSNP
rs1050969320 1107 dbSNP
rs1427956890 1110 dbSNP
rs562208474 1112 dbSNP
rs1427168908 1113 dbSNP
rs886050456 1120 dbSNP
rs886050458 1121 dbSNP
rs1428966343 1122 dbSNP
rs886050457 1122 dbSNP
rs886050460 1122 dbSNP
rs1209850630 1123 dbSNP
rs1212466355 1123 dbSNP
rs1223625514 1123 dbSNP
rs1261875034 1123 dbSNP
rs1263731233 1123 dbSNP
rs1297204626 1123 dbSNP
rs1315099876 1123 dbSNP
rs1360615544 1123 dbSNP
rs1463029470 1123 dbSNP
rs34847511 1123 dbSNP
rs532363628 1123 dbSNP
rs869200740 1123 dbSNP
rs886050459 1123 dbSNP
rs886050461 1123 dbSNP
rs886050462 1123 dbSNP
rs1226557796 1127 dbSNP
rs1454165607 1137 dbSNP
rs886050463 1145 dbSNP
rs886050464 1146 dbSNP
rs1346443247 1148 dbSNP
rs886050465 1148 dbSNP
rs890941079 1148 dbSNP
rs1300080069 1149 dbSNP
rs886050466 1150 dbSNP
rs1008999146 1151 dbSNP
rs886050467 1151 dbSNP
rs550119169 1152 dbSNP
rs1389832534 1153 dbSNP
rs930091597 1154 dbSNP
rs1265767313 1156 dbSNP
rs897832678 1158 dbSNP
rs1481136841 1159 dbSNP
rs994872636 1172 dbSNP
rs1340995683 1178 dbSNP
rs1028055970 1182 dbSNP
rs1292130231 1184 dbSNP
rs1378304289 1184 dbSNP
rs969689261 1186 dbSNP
rs1172015939 1191 dbSNP
rs1002844470 1201 dbSNP
rs1375145651 1208 dbSNP
rs568528619 1209 dbSNP
rs1391921420 1210 dbSNP
rs1400828800 1212 dbSNP
rs1017919943 1213 dbSNP
rs960826119 1217 dbSNP
rs987850650 1225 dbSNP
rs1299845823 1226 dbSNP
rs1338096776 1236 dbSNP
rs1426564417 1237 dbSNP
rs913690632 1242 dbSNP
rs533028584 1251 dbSNP
rs551289319 1261 dbSNP
rs1187408381 1265 dbSNP
rs1332322551 1271 dbSNP
rs920912137 1272 dbSNP
rs900810952 1273 dbSNP
rs1253346652 1274 dbSNP
rs1230520127 1277 dbSNP
rs1175839303 1279 dbSNP
rs1278975322 1280 dbSNP
rs1269075804 1283 dbSNP
rs1224272305 1291 dbSNP
rs1356587474 1298 dbSNP
rs997873666 1310 dbSNP
rs1318639167 1314 dbSNP
rs932605203 1326 dbSNP
rs865991436 1340 dbSNP
rs912409442 1346 dbSNP
rs1303934659 1347 dbSNP
rs1354032894 1352 dbSNP
rs1363990967 1370 dbSNP
rs1031134034 1371 dbSNP
rs1454427616 1383 dbSNP
rs566534093 1384 dbSNP
rs375191140 1386 dbSNP
rs1472438217 1415 dbSNP
rs897940444 1421 dbSNP
rs553189193 1428 dbSNP
rs1049077228 1429 dbSNP
rs1485070448 1430 dbSNP
rs1489705464 1433 dbSNP
rs568496876 1444 dbSNP
rs981073718 1449 dbSNP
rs28533800 1452 dbSNP
rs374686447 1459 dbSNP
rs778190496 1464 dbSNP
rs557359562 1466 dbSNP
rs938649627 1467 dbSNP
rs1284927429 1477 dbSNP
rs992848340 1484 dbSNP
rs1191894362 1488 dbSNP
rs575732560 1499 dbSNP
rs918673959 1510 dbSNP
rs930076867 1514 dbSNP
rs960940263 1515 dbSNP
rs1382787017 1518 dbSNP
rs1048578287 1529 dbSNP
rs1009727362 1533 dbSNP
rs1420569297 1535 dbSNP
rs749795935 1537 dbSNP
rs888638609 1546 dbSNP
rs1179011464 1547 dbSNP
rs1021068450 1549 dbSNP
rs967796383 1555 dbSNP
rs1040330429 1557 dbSNP
rs1193470878 1561 dbSNP
rs1452697105 1570 dbSNP
rs979569817 1575 dbSNP
rs901432096 1576 dbSNP
rs1259092651 1578 dbSNP
rs139856138 1579 dbSNP
rs1384984054 1582 dbSNP
rs920953838 1588 dbSNP
rs1302110965 1592 dbSNP
rs1461695813 1597 dbSNP
rs757819314 1604 dbSNP
rs1201535072 1608 dbSNP
rs953810752 1609 dbSNP
rs142179743 1610 dbSNP
rs1455196956 1613 dbSNP
rs886050468 1620 dbSNP
rs1315512923 1622 dbSNP
rs1295462284 1623 dbSNP
rs912522573 1645 dbSNP
rs746285520 1648 dbSNP
rs1434537360 1651 dbSNP
rs1407466515 1656 dbSNP
rs1339272426 1672 dbSNP
rs151193890 1674 dbSNP
rs1413065080 1675 dbSNP
rs1401969710 1678 dbSNP
rs1129622 1686 dbSNP
rs562152929 1688 dbSNP
rs1266393310 1689 dbSNP
rs1129623 1695 dbSNP
rs1212315813 1697 dbSNP
rs930756761 1699 dbSNP
rs1049576426 1700 dbSNP
rs1187376438 1708 dbSNP
rs1440330239 1711 dbSNP
rs181781975 1719 dbSNP
rs140399534 1724 dbSNP
rs746435788 1725 dbSNP
rs1441587745 1731 dbSNP
rs1056380891 1734 dbSNP
rs370360589 1740 dbSNP
rs1165278788 1741 dbSNP
rs1009758639 1751 dbSNP
rs1272832618 1753 dbSNP
rs1227670472 1755 dbSNP
rs1459839683 1762 dbSNP
rs1317716822 1767 dbSNP
rs886050469 1774 dbSNP
rs886050470 1777 dbSNP
rs551378267 1784 dbSNP
rs903993057 1785 dbSNP
rs560444801 1791 dbSNP
rs1400409460 1796 dbSNP
rs1000629918 1801 dbSNP
rs527594294 1802 dbSNP
rs1424682874 1803 dbSNP
rs953818279 1805 dbSNP
rs367861899 1818 dbSNP
rs1453490636 1819 dbSNP
rs1228500566 1827 dbSNP
rs1313917252 1828 dbSNP
rs1323841449 1831 dbSNP
rs886050471 1841 dbSNP
rs1249816789 1851 dbSNP
rs375671956 1856 dbSNP
rs1204730760 1859 dbSNP
rs1360204824 1867 dbSNP
rs1294001646 1870 dbSNP
rs10348 1875 dbSNP
rs1356245308 1876 dbSNP
rs186466589 1877 dbSNP
rs776338381 1888 dbSNP
rs7148746 1889 dbSNP
rs922841553 1899 dbSNP
rs1200677178 1905 dbSNP
rs1231218133 1906 dbSNP
rs1367099668 1907 dbSNP
rs972615873 1913 dbSNP
rs919764649 1921 dbSNP
rs1408535372 1928 dbSNP
rs189621538 1940 dbSNP
rs149945695 1941 dbSNP
rs926731952 1943 dbSNP
rs1199932071 1949 dbSNP
rs1415731444 1952 dbSNP
rs1052033420 1955 dbSNP
rs1474064062 1960 dbSNP
rs765302571 1962 dbSNP
rs1164142579 1964 dbSNP
rs892109565 1966 dbSNP
rs1285557292 1969 dbSNP
rs1010541791 1972 dbSNP
rs1327481623 1980 dbSNP
rs1288067289 1988 dbSNP
rs1043424194 2005 dbSNP
rs938098370 2007 dbSNP
rs1467113986 2010 dbSNP
rs1056416752 2011 dbSNP
rs1435114290 2015 dbSNP
rs1326321889 2019 dbSNP
rs896468399 2025 dbSNP
rs1002446438 2032 dbSNP
rs886050472 2037 dbSNP
rs181594174 2039 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uguagAUUCUGACGUUCUCAAGa 5'
               |:||::  ||:|||||| 
Target 5' ----aUGAGGU--CAGGAGUUCa 3'
1 - 17
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000281081.7 | 3UTR | AUGAGGUCAGGAGUUCAAGACCAGCCUGACCAACAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
133 hsa-miR-4680-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT378771 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT393867 ZDHHC21 zinc finger DHHC-type containing 21 2 4
MIRT446684 C2CD2 C2 calcium dependent domain containing 2 2 2
MIRT447600 MRPL3 mitochondrial ribosomal protein L3 2 2
MIRT450708 RNF152 ring finger protein 152 2 2
MIRT450784 PAPOLG poly(A) polymerase gamma 2 2
MIRT454623 COL23A1 collagen type XXIII alpha 1 chain 2 8
MIRT461620 PTCD3 pentatricopeptide repeat domain 3 2 2
MIRT462695 SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 2 2
MIRT475530 HOXA3 homeobox A3 2 8
MIRT475739 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 4
MIRT489676 CYP1A1 cytochrome P450 family 1 subfamily A member 1 2 2
MIRT490610 SLC47A1 solute carrier family 47 member 1 2 2
MIRT493628 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT496152 RPS15A ribosomal protein S15a 2 2
MIRT499232 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT501496 PRICKLE2 prickle planar cell polarity protein 2 2 2
MIRT507163 GAS2L3 growth arrest specific 2 like 3 2 2
MIRT512389 MTRNR2L1 MT-RNR2-like 1 2 4
MIRT514626 MTRNR2L7 MT-RNR2-like 7 2 2
MIRT517474 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT525332 CNGB1 cyclic nucleotide gated channel beta 1 2 2
MIRT526685 BAK1 BCL2 antagonist/killer 1 2 2
MIRT527317 CCR2 C-C motif chemokine receptor 2 2 2
MIRT527608 EYS eyes shut homolog (Drosophila) 2 2
MIRT528794 RAB32 RAB32, member RAS oncogene family 2 2
MIRT531048 TIPARP TCDD inducible poly(ADP-ribose) polymerase 2 2
MIRT532254 TBPL2 TATA-box binding protein like 2 2 2
MIRT533801 TMED7 transmembrane p24 trafficking protein 7 2 4
MIRT535887 MLEC malectin 2 2
MIRT540704 PDPK1 3-phosphoinositide dependent protein kinase 1 2 4
MIRT544645 PHF8 PHD finger protein 8 2 4
MIRT545760 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT555310 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 2
MIRT555877 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT559507 ARID5B AT-rich interaction domain 5B 2 2
MIRT560448 SLC30A7 solute carrier family 30 member 7 2 2
MIRT561262 ZIK1 zinc finger protein interacting with K protein 1 2 2
MIRT561795 PAWR pro-apoptotic WT1 regulator 2 2
MIRT567007 KLHL15 kelch like family member 15 2 2
MIRT569298 SURF6 surfeit 6 2 2
MIRT570606 MTRNR2L11 MT-RNR2-like 11 2 2
MIRT572888 ADCY2 adenylate cyclase 2 2 2
MIRT573119 ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif 18 2 2
MIRT608332 ZNF670 zinc finger protein 670 2 6
MIRT614942 KCNK5 potassium two pore domain channel subfamily K member 5 2 2
MIRT615324 ERN1 endoplasmic reticulum to nucleus signaling 1 2 2
MIRT618441 ZNF800 zinc finger protein 800 2 2
MIRT620110 HARBI1 harbinger transposase derived 1 2 2
MIRT626008 ZNF517 zinc finger protein 517 2 2
MIRT626626 SLC30A6 solute carrier family 30 member 6 2 2
MIRT627842 POU3F1 POU class 3 homeobox 1 2 2
MIRT628386 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT629305 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT629864 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT630444 IDE insulin degrading enzyme 2 2
MIRT631854 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT633173 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT633477 ZNF724P zinc finger protein 724 2 2
MIRT634395 PLSCR1 phospholipid scramblase 1 2 2
MIRT635538 TRIM72 tripartite motif containing 72 2 2
MIRT635821 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT636169 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636797 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT637952 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT645136 HES2 hes family bHLH transcription factor 2 2 2
MIRT645667 ADK adenosine kinase 2 2
MIRT646148 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT647004 NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 2 2
MIRT648187 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT650090 TERF2 telomeric repeat binding factor 2 2 2
MIRT650329 RTN2 reticulon 2 2 2
MIRT654224 RNF165 ring finger protein 165 2 2
MIRT654545 RAB1A RAB1A, member RAS oncogene family 2 2
MIRT656457 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT656828 KLF8 Kruppel like factor 8 2 2
MIRT657112 ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein like 2 2 2
MIRT657930 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT659375 CREG2 cellular repressor of E1A stimulated genes 2 2 2
MIRT659833 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT662108 LACTB lactamase beta 2 4
MIRT662789 TBC1D25 TBC1 domain family member 25 2 2
MIRT669501 ARL3 ADP ribosylation factor like GTPase 3 2 2
MIRT669759 ZNF101 zinc finger protein 101 2 4
MIRT669800 GAN gigaxonin 2 2
MIRT670050 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT670299 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670388 EMP2 epithelial membrane protein 2 2 2
MIRT672862 C22orf29 retrotransposon Gag like 10 2 2
MIRT672890 FXN frataxin 2 2
MIRT673210 C10orf76 chromosome 10 open reading frame 76 2 2
MIRT674001 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT674163 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 2
MIRT674502 TIRAP TIR domain containing adaptor protein 2 2
MIRT675470 NUBPL nucleotide binding protein like 2 2
MIRT675671 TMOD2 tropomodulin 2 2 2
MIRT676006 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT676074 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676386 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676764 SNX2 sorting nexin 2 2 2
MIRT676896 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT676978 ZNF708 zinc finger protein 708 2 2
MIRT677236 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677369 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT677464 PDLIM3 PDZ and LIM domain 3 2 2
MIRT678081 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678093 ATCAY ATCAY, caytaxin 2 2
MIRT678324 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678417 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678521 ZNF347 zinc finger protein 347 2 2
MIRT678700 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT678829 PDE6A phosphodiesterase 6A 2 2
MIRT679991 RUNDC1 RUN domain containing 1 2 2
MIRT680751 PSD4 pleckstrin and Sec7 domain containing 4 2 2
MIRT681249 ZNF383 zinc finger protein 383 2 2
MIRT681422 GTF3C6 general transcription factor IIIC subunit 6 2 2
MIRT681948 SLC19A3 solute carrier family 19 member 3 2 2
MIRT689278 C5AR2 complement component 5a receptor 2 2 2
MIRT690389 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT691845 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT693863 IYD iodotyrosine deiodinase 2 2
MIRT696002 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT701930 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT702341 KLHL7 kelch like family member 7 2 2
MIRT703557 FKBP14 FK506 binding protein 14 2 2
MIRT705033 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT706341 STAC2 SH3 and cysteine rich domain 2 2 2
MIRT709671 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT711212 EFHB EF-hand domain family member B 2 2
MIRT718342 PURA purine rich element binding protein A 2 2
MIRT722755 SIRPB2 signal regulatory protein beta 2 2 2
MIRT723535 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 2
MIRT724498 BFAR bifunctional apoptosis regulator 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4680-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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