pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CSTF1   
Synonyms CstF-50, CstFp50
Description cleavage stimulation factor subunit 1
Transcript NM_001033521   
Other Transcripts NM_001033522 , NM_001324   
Expression
Putative miRNA Targets on CSTF1
3'UTR of CSTF1
(miRNA target sites are highlighted)
>CSTF1|NM_001033521|3'UTR
   1 GCCACCCTCTCCGTAGGGTTCTTTCTCGAGGACTCTACCCTCCTCCCCCACGTCCTGTCTCAGCTGCAGTCGTAAGTCCG
  81 TGCACCATCCTTGACGTTTTGCTGCCACCTCTGTCCACATTCTTCTTGGATTTGTATAAAAGAATCTTTTTTTACCTTGA
 161 TGTAGAATCATGGTGGAAAAAGTTGGAAACACAGATCTGTGCAGTTCTACATTCACTGATTATTACAGTGTGATTTTCAT
 241 CGGTTTTGTAAGTACAGGACTTGCCGTTTCTTTTGATCTCTTGATTGAAGGAGGATAGGGCATTAAAGTGCTTTTGACAT
 321 GAGGAATTTTCATTTGGTTCTTCTGTCAACTTTCTTGCTTATTCTGCTGAACCCTCTGTGTATTTCCCTTCCAGGTATAT
 401 TTGAACAGATAAGCAGGCATGCAGCTCTGAGACTCCTGAGTTTTATGCCATTATCAAAAGCATTTTCAAGAATCCCTCAA
 481 TTCTATCCTGAAATGATGTTATTCTGATAATAAAGCTCAGATCTGCAACTTTATTGTTATATATTTTTCACTTCTGTAAA
 561 ATTAATGGCCAGTTTTTCCTGACAATTTATAGGAACAGTATCTTTCAACATACTCCCTACATTATCCTTCAATATCTGCA
 641 ATACTTGTCTTTAGTAACTGTATTTCTGGTAAGATTATGATTTCATGAGAAACAATTGAAAATATATCCGATCTAATTAA
 721 ATTAGGTCAGCCTGCTATTGCTCTCAGGTGTTGCCTGTCTTCACGAATGATTAGTATCGATTGACCTCTTTCTTAGGTG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acGGUCGGAGCGGGUcg 5'
            ||  |||| ||||  
Target 5' taCCCTCCTCCCCCAcg 3'
36 - 52 107.00 -15.80
2
miRNA  3' acggucggagCGGGUCg 5'
                    ||:||| 
Target 5' tgataataaaGCTCAGa 3'
505 - 521 104.00 -7.70
3
miRNA  3' acGGUCGGAGCGGGUcg 5'
            ||| |: :|:|||  
Target 5' tgCCACCTCTGTCCAca 3'
103 - 119 103.00 -19.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM3693700 1 COSMIC
COSM4675234 1 COSMIC
COSN8868683 5 COSMIC
COSN31575936 13 COSMIC
COSN24307034 14 COSMIC
COSN30145924 14 COSMIC
COSN30532502 18 COSMIC
COSN26972139 53 COSMIC
COSN26972141 65 COSMIC
COSN26972140 73 COSMIC
COSN15665045 76 COSMIC
COSN30157292 102 COSMIC
COSN28866525 154 COSMIC
COSN31599966 243 COSMIC
COSN30280737 276 COSMIC
COSN26425442 668 COSMIC
COSN23211868 797 COSMIC
COSN22323576 820 COSMIC
COSN16283627 1006 COSMIC
COSN24931987 1051 COSMIC
COSN2509820 1296 COSMIC
COSN7061437 1603 COSMIC
COSN21457430 1630 COSMIC
COSN21527020 1743 COSMIC
COSN20623868 1791 COSMIC
COSN30300271 1962 COSMIC
COSN30031630 2024 COSMIC
COSN1250840 2204 COSMIC
COSN15605020 2523 COSMIC
COSN27231766 2597 COSMIC
COSN27304660 2597 COSMIC
COSN7098499 2635 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs759604263 2 dbSNP
rs767553332 5 dbSNP
rs546236855 7 dbSNP
rs1251434541 8 dbSNP
rs181401266 13 dbSNP
rs750199023 14 dbSNP
rs757046491 16 dbSNP
rs758269154 17 dbSNP
rs1257230490 19 dbSNP
rs779791984 21 dbSNP
rs780906370 22 dbSNP
rs751311711 24 dbSNP
rs538212301 28 dbSNP
rs201838541 29 dbSNP
rs372870703 30 dbSNP
rs185706466 31 dbSNP
rs1284643125 35 dbSNP
rs778284558 36 dbSNP
rs749587691 37 dbSNP
rs1332711693 43 dbSNP
rs771299882 46 dbSNP
rs149041179 49 dbSNP
rs375719269 50 dbSNP
rs760835133 52 dbSNP
rs6024853 53 dbSNP
rs542730432 54 dbSNP
rs143018521 56 dbSNP
rs1317650555 59 dbSNP
rs1316341908 64 dbSNP
rs1402481432 72 dbSNP
rs1409358190 73 dbSNP
rs749112247 80 dbSNP
rs938131571 81 dbSNP
rs1313533420 82 dbSNP
rs944412005 86 dbSNP
rs768650822 92 dbSNP
rs148184670 96 dbSNP
rs545396193 97 dbSNP
rs1261961780 99 dbSNP
rs900254779 102 dbSNP
rs773966690 103 dbSNP
rs1448159082 104 dbSNP
rs1348029294 114 dbSNP
rs1218564605 119 dbSNP
rs1321242770 120 dbSNP
rs996002472 120 dbSNP
rs1224406164 121 dbSNP
rs761638765 129 dbSNP
rs902740376 133 dbSNP
rs1268568346 135 dbSNP
rs1204215099 139 dbSNP
rs887639174 143 dbSNP
rs1345845474 145 dbSNP
rs1009500268 148 dbSNP
rs565582750 159 dbSNP
rs1201269543 165 dbSNP
rs1014882900 189 dbSNP
rs1477679001 189 dbSNP
rs900655799 191 dbSNP
rs995974759 192 dbSNP
rs1422482125 194 dbSNP
rs1184347988 199 dbSNP
rs1027357474 208 dbSNP
rs773481374 210 dbSNP
rs531073440 211 dbSNP
rs115138879 215 dbSNP
rs1004470910 217 dbSNP
rs190240313 218 dbSNP
rs1264882366 221 dbSNP
rs546045358 224 dbSNP
rs1317008620 226 dbSNP
rs981746716 229 dbSNP
rs1180212486 235 dbSNP
rs1271215922 237 dbSNP
rs1216542373 242 dbSNP
rs140219472 243 dbSNP
rs958775064 244 dbSNP
rs546273916 250 dbSNP
rs16979884 253 dbSNP
rs1450473655 262 dbSNP
rs538250906 266 dbSNP
rs182315222 267 dbSNP
rs1465447648 279 dbSNP
rs1033577887 287 dbSNP
rs867533925 294 dbSNP
rs1416213659 297 dbSNP
rs75407746 299 dbSNP
rs1042390502 301 dbSNP
rs1411267213 322 dbSNP
rs1405979536 328 dbSNP
rs989016548 333 dbSNP
rs765801662 338 dbSNP
rs923921154 343 dbSNP
rs1244907849 347 dbSNP
rs1184115379 354 dbSNP
rs1457203718 355 dbSNP
rs944339976 358 dbSNP
rs146945258 362 dbSNP
rs1308320852 365 dbSNP
rs1289382648 368 dbSNP
rs752969917 375 dbSNP
rs931703769 376 dbSNP
rs1048842161 377 dbSNP
rs887597949 377 dbSNP
rs554775062 387 dbSNP
rs7806 389 dbSNP
rs1346761225 398 dbSNP
rs533942892 400 dbSNP
rs996710027 407 dbSNP
rs1354757112 411 dbSNP
rs1048805628 413 dbSNP
rs1162470410 417 dbSNP
rs780974195 418 dbSNP
rs1458104017 420 dbSNP
rs1386551729 426 dbSNP
rs745582705 433 dbSNP
rs1418406786 435 dbSNP
rs1014234593 436 dbSNP
rs6092312 437 dbSNP
rs1436997340 445 dbSNP
rs1268468228 446 dbSNP
rs1220524113 447 dbSNP
rs1024714785 458 dbSNP
rs1247505572 461 dbSNP
rs905887209 463 dbSNP
rs1315686018 476 dbSNP
rs755831910 477 dbSNP
rs1309738751 480 dbSNP
rs779371347 481 dbSNP
rs6099131 489 dbSNP
rs1014566326 498 dbSNP
rs1002024153 499 dbSNP
rs1367329001 520 dbSNP
rs1302219759 524 dbSNP
rs1402682397 530 dbSNP
rs1033133448 533 dbSNP
rs1481575620 534 dbSNP
rs748850614 535 dbSNP
rs1303250602 536 dbSNP
rs13043522 538 dbSNP
rs1452377822 539 dbSNP
rs1362001862 541 dbSNP
rs1161131581 542 dbSNP
rs139284561 555 dbSNP
rs573328904 556 dbSNP
rs1428335072 563 dbSNP
rs1002825360 564 dbSNP
rs1428691377 566 dbSNP
rs1034675244 570 dbSNP
rs1269810555 574 dbSNP
rs1466554533 577 dbSNP
rs1170124671 585 dbSNP
rs1204663201 589 dbSNP
rs1020472957 594 dbSNP
rs771516386 597 dbSNP
rs966282200 598 dbSNP
rs976382963 600 dbSNP
rs921590280 606 dbSNP
rs1225677813 607 dbSNP
rs78996198 609 dbSNP
rs186054340 610 dbSNP
rs989955901 611 dbSNP
rs1332402609 614 dbSNP
rs1382128052 617 dbSNP
rs575940634 621 dbSNP
rs544557612 633 dbSNP
rs1282047961 634 dbSNP
rs1405147500 642 dbSNP
rs761037856 643 dbSNP
rs1174023910 645 dbSNP
rs143206308 648 dbSNP
rs978159646 650 dbSNP
rs530252437 655 dbSNP
rs924000183 658 dbSNP
rs940481388 687 dbSNP
rs1263903746 694 dbSNP
rs774397035 697 dbSNP
rs1036209670 705 dbSNP
rs1249517722 708 dbSNP
rs1461279400 708 dbSNP
rs896349336 709 dbSNP
rs117639398 710 dbSNP
rs976364761 711 dbSNP
rs1324648434 718 dbSNP
rs561071975 725 dbSNP
rs1210200194 735 dbSNP
rs1226236029 738 dbSNP
rs777151702 740 dbSNP
rs932164883 750 dbSNP
rs1297070862 751 dbSNP
rs1382251444 755 dbSNP
rs1381982364 763 dbSNP
rs1490883226 765 dbSNP
rs1049195578 766 dbSNP
rs1268508001 775 dbSNP
rs1470866479 778 dbSNP
rs887927504 779 dbSNP
rs564474792 780 dbSNP
rs1374950150 786 dbSNP
rs1444011765 787 dbSNP
rs893242944 787 dbSNP
rs532067117 789 dbSNP
rs760216162 799 dbSNP
rs1020389499 801 dbSNP
rs114324599 815 dbSNP
rs1337066404 819 dbSNP
rs568735929 820 dbSNP
rs147543356 821 dbSNP
rs1454480414 829 dbSNP
rs765704609 841 dbSNP
rs1422313980 842 dbSNP
rs1302125978 843 dbSNP
rs376796723 844 dbSNP
rs1340790343 845 dbSNP
rs1398909617 848 dbSNP
rs1168648479 853 dbSNP
rs1401308032 863 dbSNP
rs1383459764 883 dbSNP
rs1166065850 894 dbSNP
rs1301261444 895 dbSNP
rs1445746387 899 dbSNP
rs1292895281 901 dbSNP
rs1439856352 902 dbSNP
rs1252249853 914 dbSNP
rs1325726909 918 dbSNP
rs62209417 919 dbSNP
rs908933368 920 dbSNP
rs953121385 920 dbSNP
rs984490826 920 dbSNP
rs75370577 921 dbSNP
rs548201607 922 dbSNP
rs1266949537 934 dbSNP
rs1356976769 935 dbSNP
rs1337291405 939 dbSNP
rs1308939340 962 dbSNP
rs1404537746 967 dbSNP
rs894362005 974 dbSNP
rs1221518401 980 dbSNP
rs568319364 981 dbSNP
rs949282900 986 dbSNP
rs1206910299 987 dbSNP
rs1157284358 989 dbSNP
rs1471394910 991 dbSNP
rs1364705821 995 dbSNP
rs1327547761 1005 dbSNP
rs8125654 1006 dbSNP
rs1428397089 1010 dbSNP
rs569511474 1012 dbSNP
rs1451618102 1021 dbSNP
rs926564383 1024 dbSNP
rs1203313784 1026 dbSNP
rs1021498038 1027 dbSNP
rs1288728024 1038 dbSNP
rs1387689692 1045 dbSNP
rs200972527 1046 dbSNP
rs370302677 1046 dbSNP
rs762079207 1047 dbSNP
rs1285358809 1050 dbSNP
rs937316934 1055 dbSNP
rs1344674756 1058 dbSNP
rs373493200 1062 dbSNP
rs1316890575 1066 dbSNP
rs1163421127 1068 dbSNP
rs1360756919 1069 dbSNP
rs1176198165 1071 dbSNP
rs191006272 1076 dbSNP
rs1286546819 1077 dbSNP
rs1201115955 1078 dbSNP
rs1383660534 1080 dbSNP
rs1240985882 1081 dbSNP
rs1396152249 1083 dbSNP
rs142136389 1083 dbSNP
rs1165686412 1086 dbSNP
rs1177846150 1086 dbSNP
rs1182899648 1086 dbSNP
rs1210498127 1086 dbSNP
rs1244722109 1086 dbSNP
rs1268647896 1086 dbSNP
rs1317650302 1086 dbSNP
rs1408747706 1086 dbSNP
rs1414662876 1086 dbSNP
rs1418296520 1086 dbSNP
rs1450985797 1086 dbSNP
rs1459867099 1086 dbSNP
rs1476071258 1086 dbSNP
rs71198364 1086 dbSNP
rs754496445 1086 dbSNP
rs768901777 1086 dbSNP
rs1317033070 1088 dbSNP
rs1380572905 1089 dbSNP
rs1054401286 1098 dbSNP
rs1244952194 1106 dbSNP
rs1309730536 1111 dbSNP
rs1214607794 1112 dbSNP
rs6024854 1113 dbSNP
rs1241484559 1114 dbSNP
rs6024855 1115 dbSNP
rs967197953 1117 dbSNP
rs1201150747 1119 dbSNP
rs1245507818 1120 dbSNP
rs1460416732 1121 dbSNP
rs1213148613 1122 dbSNP
rs1183313991 1124 dbSNP
rs1385501728 1125 dbSNP
rs181404945 1127 dbSNP
rs887811596 1128 dbSNP
rs1441887697 1129 dbSNP
rs1430258731 1133 dbSNP
rs1420464831 1141 dbSNP
rs375639343 1151 dbSNP
rs1031466050 1152 dbSNP
rs1390251453 1152 dbSNP
rs1466097413 1162 dbSNP
rs1338196193 1164 dbSNP
rs1403737865 1169 dbSNP
rs1002167883 1170 dbSNP
rs539133492 1172 dbSNP
rs1451829168 1175 dbSNP
rs976460723 1181 dbSNP
rs922226672 1182 dbSNP
rs1206880066 1186 dbSNP
rs1010271848 1192 dbSNP
rs1041815934 1194 dbSNP
rs1243812356 1198 dbSNP
rs932260157 1200 dbSNP
rs1316623899 1202 dbSNP
rs1313985316 1207 dbSNP
rs185543416 1209 dbSNP
rs901984160 1215 dbSNP
rs909417952 1218 dbSNP
rs565960052 1219 dbSNP
rs1372328034 1220 dbSNP
rs1036113438 1221 dbSNP
rs1321953641 1225 dbSNP
rs906910593 1228 dbSNP
rs938381696 1229 dbSNP
rs1481804222 1230 dbSNP
rs190644186 1231 dbSNP
rs1405478646 1236 dbSNP
rs1184668783 1244 dbSNP
rs1249361475 1247 dbSNP
rs1268402545 1254 dbSNP
rs11700131 1255 dbSNP
rs1220360785 1256 dbSNP
rs1490845563 1259 dbSNP
rs1433421097 1262 dbSNP
rs544560640 1268 dbSNP
rs1426631365 1269 dbSNP
rs953667691 1270 dbSNP
rs1011535325 1271 dbSNP
rs1469183962 1273 dbSNP
rs1315550061 1291 dbSNP
rs1309581311 1294 dbSNP
rs182932972 1295 dbSNP
rs760833370 1297 dbSNP
rs1350732767 1301 dbSNP
rs903021479 1302 dbSNP
rs1369089049 1307 dbSNP
rs1439749137 1309 dbSNP
rs1015919955 1311 dbSNP
rs961746053 1321 dbSNP
rs1343309845 1333 dbSNP
rs998654698 1335 dbSNP
rs1457516854 1339 dbSNP
rs1428881300 1345 dbSNP
rs1031098846 1349 dbSNP
rs971800433 1349 dbSNP
rs970928978 1356 dbSNP
rs1186497419 1358 dbSNP
rs980649673 1362 dbSNP
rs1270503168 1365 dbSNP
rs926506060 1366 dbSNP
rs1323258388 1376 dbSNP
rs1262187736 1381 dbSNP
rs1372802287 1387 dbSNP
rs766649389 1391 dbSNP
rs1285231719 1392 dbSNP
rs997591293 1393 dbSNP
rs1381126039 1397 dbSNP
rs1029436132 1398 dbSNP
rs1343749371 1399 dbSNP
rs953370500 1400 dbSNP
rs1166713351 1402 dbSNP
rs1053667708 1408 dbSNP
rs985045599 1410 dbSNP
rs776536500 1420 dbSNP
rs962191266 1421 dbSNP
rs574752068 1425 dbSNP
rs1467756112 1428 dbSNP
rs1378376181 1429 dbSNP
rs901943966 1430 dbSNP
rs933454395 1433 dbSNP
rs1309839757 1435 dbSNP
rs928803694 1442 dbSNP
rs1461174494 1443 dbSNP
rs1415201508 1453 dbSNP
rs938461562 1457 dbSNP
rs1055542879 1458 dbSNP
rs1202489443 1460 dbSNP
rs1050602876 1462 dbSNP
rs1484046111 1462 dbSNP
rs541038999 1462 dbSNP
rs1339435129 1463 dbSNP
rs1251106296 1464 dbSNP
rs534851859 1469 dbSNP
rs10470034 1472 dbSNP
rs1266389163 1479 dbSNP
rs1334474699 1479 dbSNP
rs1397490219 1487 dbSNP
rs189120466 1502 dbSNP
rs1016560516 1503 dbSNP
rs897461858 1504 dbSNP
rs1193837415 1505 dbSNP
rs765636642 1510 dbSNP
rs993167666 1511 dbSNP
rs1408153614 1512 dbSNP
rs1043004426 1513 dbSNP
rs1169405930 1517 dbSNP
rs903074336 1520 dbSNP
rs998717990 1521 dbSNP
rs1443298276 1523 dbSNP
rs1256491794 1525 dbSNP
rs1194870272 1528 dbSNP
rs1041299095 1530 dbSNP
rs1276132183 1531 dbSNP
rs900993375 1541 dbSNP
rs149630806 1542 dbSNP
rs1404395453 1543 dbSNP
rs1270856018 1544 dbSNP
rs1340836201 1550 dbSNP
rs532102357 1554 dbSNP
rs1213357415 1556 dbSNP
rs57790792 1557 dbSNP
rs1360590198 1558 dbSNP
rs1225234231 1564 dbSNP
rs1308745593 1565 dbSNP
rs1424020182 1566 dbSNP
rs1364268681 1567 dbSNP
rs1006141951 1570 dbSNP
rs1016482270 1575 dbSNP
rs962295859 1576 dbSNP
rs763401814 1581 dbSNP
rs972331148 1583 dbSNP
rs1471420602 1584 dbSNP
rs928832336 1590 dbSNP
rs1243350705 1593 dbSNP
rs568559980 1598 dbSNP
rs960234588 1601 dbSNP
rs991650518 1602 dbSNP
rs946025404 1603 dbSNP
rs977404822 1605 dbSNP
rs562566138 1606 dbSNP
rs947049324 1610 dbSNP
rs933402112 1624 dbSNP
rs531232463 1625 dbSNP
rs924254973 1626 dbSNP
rs1289161153 1629 dbSNP
rs1404475342 1630 dbSNP
rs1326159260 1635 dbSNP
rs548125431 1636 dbSNP
rs1384815790 1641 dbSNP
rs1040958607 1642 dbSNP
rs1459094543 1650 dbSNP
rs901039840 1652 dbSNP
rs1182442748 1654 dbSNP
rs11905070 1654 dbSNP
rs1037919754 1656 dbSNP
rs898099090 1662 dbSNP
rs11905108 1669 dbSNP
rs796149665 1671 dbSNP
rs192078950 1672 dbSNP
rs1269085102 1675 dbSNP
rs8183916 1676 dbSNP
rs1223102189 1681 dbSNP
rs889168274 1683 dbSNP
rs6024856 1685 dbSNP
rs1016249651 1688 dbSNP
rs1437235854 1698 dbSNP
rs539170308 1702 dbSNP
rs989291129 1703 dbSNP
rs1020798524 1706 dbSNP
rs966586007 1708 dbSNP
rs558799067 1722 dbSNP
rs897819950 1723 dbSNP
rs183972217 1725 dbSNP
rs370644175 1726 dbSNP
rs111748077 1727 dbSNP
rs1478035394 1729 dbSNP
rs375097993 1730 dbSNP
rs1022740785 1746 dbSNP
rs968480252 1747 dbSNP
rs910630871 1748 dbSNP
rs1214508963 1750 dbSNP
rs879747580 1751 dbSNP
rs924305820 1752 dbSNP
rs757298599 1762 dbSNP
rs977076558 1763 dbSNP
rs1384408886 1765 dbSNP
rs922508212 1769 dbSNP
rs1440945456 1770 dbSNP
rs932489040 1774 dbSNP
rs1280923966 1775 dbSNP
rs1049525875 1776 dbSNP
rs368399942 1777 dbSNP
rs888268481 1778 dbSNP
rs778904970 1779 dbSNP
rs1410487826 1783 dbSNP
rs1231225001 1791 dbSNP
rs1366490122 1791 dbSNP
rs1037751117 1792 dbSNP
rs1399017557 1794 dbSNP
rs1446187078 1795 dbSNP
rs753268091 1799 dbSNP
rs1335763791 1808 dbSNP
rs745423038 1811 dbSNP
rs191255529 1812 dbSNP
rs896047747 1818 dbSNP
rs184031054 1821 dbSNP
rs6024857 1824 dbSNP
rs1023166495 1831 dbSNP
rs968865390 1834 dbSNP
rs553978122 1838 dbSNP
rs1471657202 1839 dbSNP
rs906163485 1842 dbSNP
rs1382531870 1844 dbSNP
rs533326032 1845 dbSNP
rs115852666 1849 dbSNP
rs1280898250 1852 dbSNP
rs1348186837 1855 dbSNP
rs1222645555 1861 dbSNP
rs1314890024 1863 dbSNP
rs1031386248 1866 dbSNP
rs376126138 1869 dbSNP
rs1381793690 1879 dbSNP
rs976414049 1880 dbSNP
rs186842925 1882 dbSNP
rs1201709523 1888 dbSNP
rs932606841 1895 dbSNP
rs985337585 1896 dbSNP
rs1020725094 1902 dbSNP
rs1305676927 1903 dbSNP
rs116236411 1907 dbSNP
rs1371106012 1909 dbSNP
rs56269601 1910 dbSNP
rs1163978924 1919 dbSNP
rs1403434986 1926 dbSNP
rs1415664239 1927 dbSNP
rs1030001283 1931 dbSNP
rs1472402948 1936 dbSNP
rs576049608 1938 dbSNP
rs954695146 1940 dbSNP
rs748016927 1942 dbSNP
rs1483414727 1943 dbSNP
rs1291772717 1948 dbSNP
rs1183803435 1951 dbSNP
rs1219969089 1953 dbSNP
rs1323931755 1961 dbSNP
rs1291064453 1963 dbSNP
rs1223538761 1965 dbSNP
rs1349505140 1976 dbSNP
rs1286014700 1977 dbSNP
rs772013444 1986 dbSNP
rs777498713 1988 dbSNP
rs541503813 1991 dbSNP
rs1292915055 1993 dbSNP
rs986557099 2002 dbSNP
rs1351502620 2008 dbSNP
rs977204812 2023 dbSNP
rs1165221017 2030 dbSNP
rs1234804531 2032 dbSNP
rs1456454388 2034 dbSNP
rs941160598 2037 dbSNP
rs1468812561 2039 dbSNP
rs963445135 2044 dbSNP
rs746839901 2045 dbSNP
rs1430111758 2056 dbSNP
rs55853012 2064 dbSNP
rs185297883 2065 dbSNP
rs547699347 2068 dbSNP
rs1247736750 2070 dbSNP
rs895792704 2072 dbSNP
rs1410877809 2073 dbSNP
rs1331303620 2097 dbSNP
rs1327512101 2100 dbSNP
rs1046602833 2101 dbSNP
rs776957319 2103 dbSNP
rs1329358376 2104 dbSNP
rs1300023348 2109 dbSNP
rs542424714 2111 dbSNP
rs1283310334 2113 dbSNP
rs1055185310 2118 dbSNP
rs1294028443 2127 dbSNP
rs1434178145 2129 dbSNP
rs1346822087 2132 dbSNP
rs1322863952 2139 dbSNP
rs562095741 2146 dbSNP
rs1377244207 2148 dbSNP
rs775716359 2150 dbSNP
rs1262426792 2154 dbSNP
rs1010608694 2155 dbSNP
rs564339720 2156 dbSNP
rs1426560980 2159 dbSNP
rs1340054357 2160 dbSNP
rs533185336 2171 dbSNP
rs1463859612 2173 dbSNP
rs1042153413 2182 dbSNP
rs902321560 2184 dbSNP
rs1000331001 2200 dbSNP
rs549906113 2203 dbSNP
rs1230509994 2204 dbSNP
rs1313434960 2212 dbSNP
rs1301942357 2213 dbSNP
rs1270630709 2214 dbSNP
rs190147899 2217 dbSNP
rs569291765 2218 dbSNP
rs1181758865 2223 dbSNP
rs182315587 2230 dbSNP
rs1435461268 2231 dbSNP
rs1029365669 2244 dbSNP
rs1301307557 2251 dbSNP
rs953713407 2252 dbSNP
rs763495738 2253 dbSNP
rs1359785164 2266 dbSNP
rs1167982099 2268 dbSNP
rs548319412 2269 dbSNP
rs1197447884 2271 dbSNP
rs1017601282 2280 dbSNP
rs139356062 2286 dbSNP
rs533895703 2287 dbSNP
rs1476028139 2291 dbSNP
rs1255125463 2297 dbSNP
rs962531935 2302 dbSNP
rs554063545 2304 dbSNP
rs1483974762 2312 dbSNP
rs6099132 2318 dbSNP
rs1169964442 2325 dbSNP
rs543194663 2329 dbSNP
rs972516329 2334 dbSNP
rs1429564193 2336 dbSNP
rs918398852 2337 dbSNP
rs1299658407 2339 dbSNP
rs1227964595 2343 dbSNP
rs1339652334 2344 dbSNP
rs1303347485 2358 dbSNP
rs1310902517 2362 dbSNP
rs577078755 2363 dbSNP
rs185640670 2368 dbSNP
rs917294335 2370 dbSNP
rs948660585 2383 dbSNP
rs1427832954 2384 dbSNP
rs982699108 2386 dbSNP
rs1229561380 2390 dbSNP
rs556711384 2390 dbSNP
rs11475247 2391 dbSNP
rs1457754613 2391 dbSNP
rs398088523 2391 dbSNP
rs1268147902 2393 dbSNP
rs1425220756 2397 dbSNP
rs1257700238 2400 dbSNP
rs938243839 2400 dbSNP
rs1044675711 2401 dbSNP
rs904745558 2404 dbSNP
rs576106012 2406 dbSNP
rs1263484710 2407 dbSNP
rs751930869 2407 dbSNP
rs1490919633 2411 dbSNP
rs144086977 2425 dbSNP
rs1408149930 2426 dbSNP
rs997986630 2427 dbSNP
rs79827607 2433 dbSNP
rs35839613 2435 dbSNP
rs1266797433 2445 dbSNP
rs6014718 2451 dbSNP
rs765936258 2464 dbSNP
rs1371889472 2468 dbSNP
rs753594645 2475 dbSNP
rs1418197237 2476 dbSNP
rs1449238020 2482 dbSNP
rs572088409 2489 dbSNP
rs1157957515 2495 dbSNP
rs1164676883 2498 dbSNP
rs1006485666 2499 dbSNP
rs1016826273 2508 dbSNP
rs1181846564 2508 dbSNP
rs962625738 2509 dbSNP
rs541000259 2516 dbSNP
rs933814716 2517 dbSNP
rs973049467 2519 dbSNP
rs1335229237 2528 dbSNP
rs1267783536 2539 dbSNP
rs188320852 2546 dbSNP
rs754591693 2548 dbSNP
rs1280243792 2550 dbSNP
rs1232538116 2554 dbSNP
rs1329872423 2561 dbSNP
rs180678367 2565 dbSNP
rs778341726 2566 dbSNP
rs960818819 2571 dbSNP
rs533245733 2572 dbSNP
rs369381869 2573 dbSNP
rs752230803 2577 dbSNP
rs1375922253 2584 dbSNP
rs1026379949 2585 dbSNP
rs577173950 2585 dbSNP
rs950844263 2586 dbSNP
rs980073375 2586 dbSNP
rs549756344 2587 dbSNP
rs115572180 2589 dbSNP
rs1361805380 2593 dbSNP
rs1035591614 2597 dbSNP
rs1053779134 2598 dbSNP
rs1277163016 2600 dbSNP
rs1235640047 2607 dbSNP
rs762162643 2626 dbSNP
rs1486215465 2633 dbSNP
rs1207038712 2634 dbSNP
rs1437646772 2635 dbSNP
rs1346652154 2636 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084040. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep1 HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acggUCGG-AGCGggucg 5'
              ||||  |||     
Target 5' cgugAGCCACCGC----- 3'
15 - 27
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084040
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep1
Location of target site ENST00000217109.4 | 3UTR | UUUUGGGAUUACAGGCGUGAGCCACCGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000217109.4 | 3UTR | UUUGGGAUUACAGGCGUGAGCCACCGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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