pre-miRNA Information
pre-miRNA hsa-mir-7161   
Genomic Coordinates chr6: 158609707 - 158609790
Description Homo sapiens miR-7161 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-7161-5p
Sequence 1| UAAAGACUGUAGAGGCAACUGGU |23
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1198027002 1 dbSNP
rs530077902 10 dbSNP
rs1446817450 13 dbSNP
rs774892048 14 dbSNP
rs1438482648 16 dbSNP
rs1167166990 19 dbSNP
rs760372681 19 dbSNP
Putative Targets

Gene Information
Gene Symbol TMPPE   
Synonyms -
Description transmembrane protein with metallophosphoesterase domain
Transcript NM_001039770   
Other Transcripts NM_001136238   
Expression
Putative miRNA Targets on TMPPE
3'UTR of TMPPE
(miRNA target sites are highlighted)
>TMPPE|NM_001039770|3'UTR
   1 ACTGGCCCTGCCCTGTGCACCTCTGCCCTGCCCTTGTCCTCGACCCTCCATCCTGCTTCAGAGTGGTTTGCCTGCTTTTC
  81 CCCTCCAGCCTTGCCCACTCATCCTTGCCTACACACCCTTGGTCACAAGCCTGACTCAAACAGTGACTTATGGTGGGCCT
 161 GCCTGGCATGTTCAGGCTGGTTTAACTATTTCCTTGGCCAGTTGCTTTTTTTGATGCACTTGTGAGATCACTAAGGTCAC
 241 ATATATTAGCACTCCCCTCTATTTTCCAGATGATGTGGAATGGGGACCTTCTCCTGCAGAGCTCCCAGGGATGAACCTCC
 321 CCTCGGGGTTGCTAGAAAGGCATACCTCTAGAAGGTGGGGCGGGGAGGAGCAGGAGCATTTTTCTCCTGGTGTTTTAAAA
 401 TTGTCTTTAGGACTTAAGTGGTTTCCAGAATCATTGATCCAGAGCCTTTCTGGGGAAGGGGTAGTGTTGCCAGGTAATTT
 481 GGGAGAACAGGCAAGATGGAAGGGCCCTCTGGCTGCTAGAGAAGAATATTTTCTTTTCCTCTGATTCTATCAGGATCACC
 561 TCTATTGAGGGCATCAGCAAAATCTACTGGAATGCAAAGCTCCTCCTGTTCCAGGCCTTGAGGGATGCTATTTAACTGTC
 641 TGTGCTCCTGGGCCTTTGGGGGCAAGGTCAGGGGAGAAGAACGGTGGGCGCCATGGTCGGTGATGGTGAGAACATGGCTG
 721 CTTAGGAATTCAGAGGGCTTTGCCTCCCTTGTCTCATTTTATACAACCCTTCGGGGAGCTCACTGGGGACAGGCTGCTTT
 801 TCCCTATTTGGAGATAAGGAAACCAAGGCAAAGAGAGATAGGGCACAGGCAGTATGACAAGATATGTAGGAGATTTGGGG
 881 CTAGAAACCAGGTCTTGTACCTCCCAGTAAAAGCGGTGCTTTTGCCCTTTTGCCAGAAGCAATAGATCCTTTGATCCTGA
 961 GATGGAGATAAGCACCCGTGTTAGAAAAGGCCTCACTGAGAAGACAGGGCTGGGCTGGTTTCCTGCTGGGTGATTTAGGC
1041 TTGTGATGGAAAGTCTTCCTCCAATGGGGAGTGAAGACACTCGCTCTGACTGGAGAGGCTAACCCTGCTGCTCACTCATA
1121 GGGCAGCGTTGGGTGGGTGACTTTCCCTCACTCAGCCTTGGTTTCCATCAACCCTAAAATGGGGATAATTATCGTATCTA
1201 CCTCAAGATTGTTTTGTCAGGAGGGATCCATCAAGCCTTGTGCATGAGTTCCACATGGCACAGCGTGCACAGTAAACACT
1281 CAATGTTAATTTTTCAACGTTCCAGTGGAGCTTGCTAAGGAACTCTGTTGGGCACAGGTGCCCAGAGGATTCATGGAGCA
1361 GCCAGTCCTGGGGAATGTGAGTGGGTAGCGAGCTGCCTGCTGCTGGGGCAGGTGATGTGTCAAAGCAGCAACTGCTAGGG
1441 GTTTGCCTTCCTTCCCTCATGTGCATTCTGGCAGGCAAAGGGGGTTTCTTCCTTTCCTCCTTGTCCTCCTGGTGTATAGT
1521 GGGGTTCTGGGGGATCTGGAGACCACCCTTTTTGTTCCCAGGCAGCCACGGTATTGACAGTGGGCCATACCATGCAGTTT
1601 AAAATGTATCTTTGAGTTGAAATTTTGGTGGTTTCCTTATTCTTTTTTCTCTCTTCACTGTCCTTCCAAACTCACTTTTC
1681 TTGTGTCCCGACCGCATTTTGTGAATCATCCTTACTCCCTTTAAGTTCTCGCTTTGGATTTCACCAGGTGGGCTAGATGG
1761 TGCCATTTCACTTCCACTGTTTGATGCGGCTGGTAATGTTTGACTCACCTGTTACGTGTTATTTCACTGGTTTCTTGATT
1841 TTACATCTTTCTCATCAGTGACCTGGGCTTGATGAAATTAGCTTTCATTAAGTCCTATTTTTTTTTTAATTTTGCATCCT
1921 TACCTCTTTTCTTTCTCTTGAATGCCATCATTGTGTGGTCTTATGTACCCTTCATCCACTCTGAAGTCCTTGCTTGACTG
2001 ATTGCTTTCTATTAGCAGAAAGAAAACAGGTCCATCCTATGTATCTGAGAAACAACATCAACACCCTCTCGTATGTGGTT
2081 TGTATTCCCTGACGCGGCGGACATTTTTGCAGCAGAAATTTCTCCATCACTGTCCAGATTCTGGCCCTGGTGGGCAGGTC
2161 TCCATGACACCTTTAGTCCCTTTGTTCAACATTCTTAAACCATGGACCTTTTTGTTTGTTTGTGGCCGGGGGAGGTGGTG
2241 AGAAACGTTACTTGAAGCTTGATCATTCTTTCAATTTCATTTGTTTCTTTATTTTTAATCTGTTAGATGCAAATTGAAAT
2321 GCAATGCTTTTTGAAAATCAGCAATAGTGTCTGTAGTATATGATGCTGTCACAAAATCTCAATAAATTGATCCTGCTGCC
2401 ATTCCTTCCAAATACCCAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugGUCAACGGAGAUGUCAGAAAu 5'
            ::|| |::||  :| ||||| 
Target 5' ttTGGTGGTTTCCTTATTCTTTt 3'
1624 - 1646 129.00 -7.90
2
miRNA  3' ugGUC--AACG-GAGAUGUCAGAAau 5'
            :||  |||:  |  | ||||||  
Target 5' ttTAGGCTTGTGATGGAAAGTCTTcc 3'
1034 - 1059 127.00 -8.70
3
miRNA  3' uggucaacgGAGAUGUCAGAAAu 5'
                   ||||: |||| || 
Target 5' cttcatccaCTCTGAAGTCCTTg 3'
1970 - 1992 126.00 -11.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26999185 10 COSMIC
COSN30463733 13 COSMIC
COSN30464543 28 COSMIC
COSN30477435 33 COSMIC
COSN14060285 41 COSMIC
COSN30463712 41 COSMIC
COSN31514301 79 COSMIC
COSN30165531 100 COSMIC
COSN30530426 104 COSMIC
COSN25757294 689 COSMIC
COSN18723535 875 COSMIC
COSN29544327 977 COSMIC
COSN27573736 1499 COSMIC
COSN25316336 1696 COSMIC
COSN7606246 2098 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs754255022 2 dbSNP
rs1220323010 6 dbSNP
rs927222461 7 dbSNP
rs1356779854 10 dbSNP
rs778222963 13 dbSNP
rs1276391363 19 dbSNP
rs1354785484 20 dbSNP
rs756708185 25 dbSNP
rs753218591 29 dbSNP
rs1293273941 35 dbSNP
rs777541686 36 dbSNP
rs767096951 37 dbSNP
rs758950218 39 dbSNP
rs751284222 41 dbSNP
rs114144251 42 dbSNP
rs762528468 44 dbSNP
rs773006491 46 dbSNP
rs377398538 48 dbSNP
rs761777784 50 dbSNP
rs974648259 55 dbSNP
rs754989419 61 dbSNP
rs1260546114 62 dbSNP
rs1442676994 72 dbSNP
rs913244018 78 dbSNP
rs1366512191 80 dbSNP
rs943204669 81 dbSNP
rs1159813295 89 dbSNP
rs1285208044 90 dbSNP
rs911699153 93 dbSNP
rs1458871351 96 dbSNP
rs988783630 107 dbSNP
rs986899783 111 dbSNP
rs1336461007 112 dbSNP
rs143210705 117 dbSNP
rs1339069120 130 dbSNP
rs1331382513 131 dbSNP
rs1289498698 137 dbSNP
rs1020101961 138 dbSNP
rs72856190 143 dbSNP
rs1345217240 150 dbSNP
rs1025718613 151 dbSNP
rs972766289 153 dbSNP
rs962741610 159 dbSNP
rs1370582703 166 dbSNP
rs1167603449 168 dbSNP
rs1253729767 180 dbSNP
rs1017608436 186 dbSNP
rs1485206910 187 dbSNP
rs1001761604 192 dbSNP
rs906040502 193 dbSNP
rs1253828446 198 dbSNP
rs1427462985 213 dbSNP
rs1156957923 217 dbSNP
rs757811652 219 dbSNP
rs1014357778 220 dbSNP
rs891576155 235 dbSNP
rs57682151 247 dbSNP
rs115764170 254 dbSNP
rs1414494588 266 dbSNP
rs578140443 270 dbSNP
rs1309049856 275 dbSNP
rs1014554781 277 dbSNP
rs1004929675 293 dbSNP
rs1039375412 294 dbSNP
rs1235680826 296 dbSNP
rs1183846530 302 dbSNP
rs552338160 304 dbSNP
rs1234836929 320 dbSNP
rs895589840 323 dbSNP
rs943274804 324 dbSNP
rs911791613 325 dbSNP
rs557819483 327 dbSNP
rs1251226318 328 dbSNP
rs1203086270 329 dbSNP
rs1042879519 331 dbSNP
rs987329316 337 dbSNP
rs929114211 343 dbSNP
rs1053149530 349 dbSNP
rs944026671 350 dbSNP
rs918716380 361 dbSNP
rs972806368 362 dbSNP
rs1372786922 368 dbSNP
rs1354615853 387 dbSNP
rs1281803337 390 dbSNP
rs912683705 392 dbSNP
rs1368983596 395 dbSNP
rs1387959514 397 dbSNP
rs867460201 403 dbSNP
rs190393798 404 dbSNP
rs777861521 410 dbSNP
rs980780967 413 dbSNP
rs970360934 415 dbSNP
rs1299444997 420 dbSNP
rs920099651 421 dbSNP
rs1203618656 427 dbSNP
rs1265908522 430 dbSNP
rs974181925 432 dbSNP
rs1211642842 435 dbSNP
rs961621315 441 dbSNP
rs1453927210 452 dbSNP
rs1189451243 454 dbSNP
rs1015779837 461 dbSNP
rs1392301800 465 dbSNP
rs1004580254 471 dbSNP
rs1351264237 488 dbSNP
rs959965324 491 dbSNP
rs566139698 499 dbSNP
rs1323746282 505 dbSNP
rs547830265 507 dbSNP
rs1292350273 508 dbSNP
rs1411313192 511 dbSNP
rs1161067599 515 dbSNP
rs1435233234 521 dbSNP
rs1322108653 524 dbSNP
rs1472906018 529 dbSNP
rs60798803 530 dbSNP
rs1031390529 533 dbSNP
rs752898993 544 dbSNP
rs1180195361 549 dbSNP
rs904203930 558 dbSNP
rs1038718692 559 dbSNP
rs1007623049 564 dbSNP
rs1247524526 565 dbSNP
rs1250085119 590 dbSNP
rs551287893 593 dbSNP
rs769168373 597 dbSNP
rs1414955946 600 dbSNP
rs1425992661 601 dbSNP
rs747877211 603 dbSNP
rs1051677609 607 dbSNP
rs929128988 611 dbSNP
rs1417831845 622 dbSNP
rs1457264326 628 dbSNP
rs145092087 633 dbSNP
rs1037537372 638 dbSNP
rs1429605533 640 dbSNP
rs1209722919 642 dbSNP
rs1329135857 644 dbSNP
rs941431666 645 dbSNP
rs1292575637 647 dbSNP
rs1329802963 658 dbSNP
rs912558641 659 dbSNP
rs1315297082 666 dbSNP
rs909939877 669 dbSNP
rs1238307474 671 dbSNP
rs544174256 671 dbSNP
rs780990244 672 dbSNP
rs970023464 674 dbSNP
rs932750184 675 dbSNP
rs1257380926 678 dbSNP
rs1473206239 680 dbSNP
rs532024317 682 dbSNP
rs1435361376 683 dbSNP
rs781691359 688 dbSNP
rs917502206 689 dbSNP
rs564560833 690 dbSNP
rs1176295497 693 dbSNP
rs1360589747 698 dbSNP
rs993006570 699 dbSNP
rs974232900 707 dbSNP
rs117541625 710 dbSNP
rs1031776486 715 dbSNP
rs1156786366 730 dbSNP
rs908827828 741 dbSNP
rs755453646 765 dbSNP
rs572067041 766 dbSNP
rs1000751478 772 dbSNP
rs968524349 773 dbSNP
rs1314194114 777 dbSNP
rs1209087047 779 dbSNP
rs1017762047 783 dbSNP
rs1007262945 788 dbSNP
rs370137420 790 dbSNP
rs1051691955 791 dbSNP
rs1231713587 793 dbSNP
rs1469164761 794 dbSNP
rs536553299 817 dbSNP
rs1191292177 820 dbSNP
rs1426786224 827 dbSNP
rs1432487165 831 dbSNP
rs969819558 835 dbSNP
rs1021371959 846 dbSNP
rs1370928343 860 dbSNP
rs186330143 864 dbSNP
rs574045039 865 dbSNP
rs1477188763 868 dbSNP
rs555734051 870 dbSNP
rs1353878718 877 dbSNP
rs1441512343 882 dbSNP
rs747321042 883 dbSNP
rs1011451925 900 dbSNP
rs531165765 904 dbSNP
rs1031466801 906 dbSNP
rs897682192 914 dbSNP
rs570707753 915 dbSNP
rs1271444357 916 dbSNP
rs753605646 942 dbSNP
rs941846514 946 dbSNP
rs1050207318 954 dbSNP
rs1206083686 956 dbSNP
rs1313267661 973 dbSNP
rs1278778928 977 dbSNP
rs1218119503 978 dbSNP
rs149919617 988 dbSNP
rs898613963 990 dbSNP
rs1458664508 993 dbSNP
rs1299276894 1000 dbSNP
rs1044872038 1006 dbSNP
rs780710690 1013 dbSNP
rs940231569 1017 dbSNP
rs908706339 1019 dbSNP
rs948730338 1033 dbSNP
rs1396781889 1036 dbSNP
rs992311436 1042 dbSNP
rs1325447319 1048 dbSNP
rs533956953 1064 dbSNP
rs926877102 1069 dbSNP
rs979794237 1070 dbSNP
rs1339239749 1072 dbSNP
rs1229384970 1073 dbSNP
rs1275677912 1074 dbSNP
rs1412935228 1078 dbSNP
rs969706690 1082 dbSNP
rs1465977601 1083 dbSNP
rs993057390 1083 dbSNP
rs1412829812 1084 dbSNP
rs956313632 1099 dbSNP
rs1021426130 1103 dbSNP
rs566052961 1110 dbSNP
rs1164894653 1118 dbSNP
rs1415647304 1119 dbSNP
rs978985328 1122 dbSNP
rs955783278 1123 dbSNP
rs1384152754 1125 dbSNP
rs1389571363 1125 dbSNP
rs969287320 1127 dbSNP
rs1017355096 1128 dbSNP
rs1295595755 1129 dbSNP
rs1007283390 1134 dbSNP
rs1333373300 1140 dbSNP
rs1008037203 1147 dbSNP
rs1246616036 1150 dbSNP
rs891057805 1153 dbSNP
rs1268222989 1157 dbSNP
rs758897598 1157 dbSNP
rs1203000554 1178 dbSNP
rs1483900283 1182 dbSNP
rs139154601 1187 dbSNP
rs150633243 1193 dbSNP
rs1038293517 1198 dbSNP
rs1255272500 1199 dbSNP
rs375997439 1204 dbSNP
rs1474843437 1213 dbSNP
rs1412783126 1216 dbSNP
rs940116619 1216 dbSNP
rs1455476776 1217 dbSNP
rs1157018647 1224 dbSNP
rs897775626 1226 dbSNP
rs765404680 1232 dbSNP
rs1415358909 1234 dbSNP
rs1315181272 1238 dbSNP
rs1354045710 1246 dbSNP
rs36075372 1253 dbSNP
rs887176945 1255 dbSNP
rs1289598827 1264 dbSNP
rs142859087 1265 dbSNP
rs1340978131 1269 dbSNP
rs1006093696 1270 dbSNP
rs1397547207 1274 dbSNP
rs1379890955 1282 dbSNP
rs939522485 1283 dbSNP
rs1277943790 1286 dbSNP
rs757252252 1297 dbSNP
rs1182810945 1298 dbSNP
rs904989568 1299 dbSNP
rs926903470 1304 dbSNP
rs1179782930 1313 dbSNP
rs1372443276 1327 dbSNP
rs550185272 1329 dbSNP
rs1478485920 1340 dbSNP
rs1175822901 1344 dbSNP
rs1374020199 1352 dbSNP
rs981020317 1357 dbSNP
rs1169267483 1365 dbSNP
rs946915151 1368 dbSNP
rs1389135392 1375 dbSNP
rs531941264 1389 dbSNP
rs1429404662 1390 dbSNP
rs1331270153 1395 dbSNP
rs564771659 1399 dbSNP
rs1388540621 1402 dbSNP
rs1167437928 1410 dbSNP
rs1424694638 1414 dbSNP
rs1413725007 1426 dbSNP
rs1252956696 1429 dbSNP
rs1180570154 1431 dbSNP
rs989787546 1433 dbSNP
rs181498222 1436 dbSNP
rs1031399853 1440 dbSNP
rs1469015261 1446 dbSNP
rs1044499558 1451 dbSNP
rs10865849 1453 dbSNP
rs559819297 1456 dbSNP
rs1192217810 1458 dbSNP
rs116853659 1459 dbSNP
rs1253393345 1461 dbSNP
rs955225518 1465 dbSNP
rs1480020544 1469 dbSNP
rs1298165874 1471 dbSNP
rs1390823330 1473 dbSNP
rs1028235241 1475 dbSNP
rs574183152 1477 dbSNP
rs1369822805 1497 dbSNP
rs1228777836 1502 dbSNP
rs924925789 1512 dbSNP
rs1482557184 1516 dbSNP
rs962568258 1521 dbSNP
rs1016909780 1534 dbSNP
rs1004152979 1537 dbSNP
rs1322036698 1539 dbSNP
rs979382760 1544 dbSNP
rs1335524123 1549 dbSNP
rs562176735 1554 dbSNP
rs1251330495 1563 dbSNP
rs544171229 1566 dbSNP
rs188214950 1569 dbSNP
rs11711396 1570 dbSNP
rs1264285678 1570 dbSNP
rs1419274147 1571 dbSNP
rs1462517613 1572 dbSNP
rs1162171983 1577 dbSNP
rs1393200192 1579 dbSNP
rs1435342578 1580 dbSNP
rs1030074186 1583 dbSNP
rs1359563516 1585 dbSNP
rs375165483 1586 dbSNP
rs1308778704 1589 dbSNP
rs946967455 1592 dbSNP
rs1235142635 1605 dbSNP
rs971759312 1606 dbSNP
rs962012894 1610 dbSNP
rs915471920 1619 dbSNP
rs201587522 1627 dbSNP
rs1006521378 1632 dbSNP
rs1295450196 1649 dbSNP
rs1485086707 1650 dbSNP
rs554794864 1651 dbSNP
rs1258785630 1653 dbSNP
rs757642612 1656 dbSNP
rs1054145489 1671 dbSNP
rs1186494658 1675 dbSNP
rs1416515987 1687 dbSNP
rs528937738 1689 dbSNP
rs568546200 1690 dbSNP
rs1013358820 1693 dbSNP
rs895937030 1694 dbSNP
rs1473883758 1696 dbSNP
rs1413326023 1700 dbSNP
rs1313266825 1711 dbSNP
rs1357225622 1715 dbSNP
rs986564373 1718 dbSNP
rs1292669471 1719 dbSNP
rs1354870687 1724 dbSNP
rs569277545 1730 dbSNP
rs1309365101 1731 dbSNP
rs183853728 1737 dbSNP
rs538204327 1743 dbSNP
rs921103323 1744 dbSNP
rs975186628 1747 dbSNP
rs1257504116 1748 dbSNP
rs962627152 1757 dbSNP
rs1488585983 1765 dbSNP
rs72856187 1775 dbSNP
rs768404814 1776 dbSNP
rs1211576175 1782 dbSNP
rs1331230442 1784 dbSNP
rs1173931899 1785 dbSNP
rs1004655522 1787 dbSNP
rs1432700164 1788 dbSNP
rs1211804337 1796 dbSNP
rs1288838811 1798 dbSNP
rs951411973 1806 dbSNP
rs910788690 1807 dbSNP
rs1003640802 1808 dbSNP
rs1348660525 1813 dbSNP
rs1239659585 1815 dbSNP
rs905251159 1815 dbSNP
rs1045278438 1816 dbSNP
rs1390256564 1823 dbSNP
rs552789891 1830 dbSNP
rs368301816 1857 dbSNP
rs1292203618 1858 dbSNP
rs140014506 1859 dbSNP
rs986327652 1878 dbSNP
rs147454856 1885 dbSNP
rs1390024794 1886 dbSNP
rs923055747 1891 dbSNP
rs1456268553 1894 dbSNP
rs971769160 1907 dbSNP
rs140320259 1908 dbSNP
rs894089354 1908 dbSNP
rs1361603846 1909 dbSNP
rs548355737 1911 dbSNP
rs1433470351 1914 dbSNP
rs934359178 1918 dbSNP
rs538819626 1919 dbSNP
rs181831538 1923 dbSNP
rs1268720243 1929 dbSNP
rs1207985587 1937 dbSNP
rs1373476941 1947 dbSNP
rs114462916 1949 dbSNP
rs920995308 1963 dbSNP
rs1216799531 1968 dbSNP
rs975246986 1969 dbSNP
rs1306399395 1970 dbSNP
rs1213782875 1972 dbSNP
rs1023498350 1978 dbSNP
rs1192718959 1983 dbSNP
rs1257882466 1988 dbSNP
rs543876565 1991 dbSNP
rs576726047 1992 dbSNP
rs564724314 2008 dbSNP
rs777099902 2010 dbSNP
rs941190055 2011 dbSNP
rs1418730378 2029 dbSNP
rs960486497 2030 dbSNP
rs540563533 2033 dbSNP
rs544353456 2037 dbSNP
rs373575013 2039 dbSNP
rs1165791637 2041 dbSNP
rs560095622 2054 dbSNP
rs1438955141 2055 dbSNP
rs752142709 2058 dbSNP
rs903204642 2070 dbSNP
rs1043476357 2071 dbSNP
rs759335347 2073 dbSNP
rs1268873291 2075 dbSNP
rs1404967964 2077 dbSNP
rs1011565871 2086 dbSNP
rs189476239 2087 dbSNP
rs1050665254 2091 dbSNP
rs771367828 2093 dbSNP
rs982499450 2095 dbSNP
rs1208869315 2098 dbSNP
rs1376733638 2099 dbSNP
rs923400858 2101 dbSNP
rs536424942 2103 dbSNP
rs1241409984 2109 dbSNP
rs143050102 2111 dbSNP
rs1420074617 2112 dbSNP
rs940458818 2120 dbSNP
rs185079305 2128 dbSNP
rs1162875571 2133 dbSNP
rs1385959883 2134 dbSNP
rs1402733412 2142 dbSNP
rs575286004 2147 dbSNP
rs762998855 2150 dbSNP
rs1360389588 2153 dbSNP
rs1415908151 2160 dbSNP
rs984897680 2164 dbSNP
rs375369656 2171 dbSNP
rs1279706689 2172 dbSNP
rs1330286865 2173 dbSNP
rs7612234 2182 dbSNP
rs1285017286 2185 dbSNP
rs916499422 2187 dbSNP
rs1485899252 2189 dbSNP
rs1031547953 2190 dbSNP
rs1255387123 2194 dbSNP
rs1474232571 2205 dbSNP
rs1258171189 2227 dbSNP
rs1201111094 2234 dbSNP
rs1471290649 2242 dbSNP
rs1157094761 2245 dbSNP
rs1344326588 2246 dbSNP
rs552279483 2247 dbSNP
rs1315288981 2249 dbSNP
rs890672481 2264 dbSNP
rs960540057 2266 dbSNP
rs1394907506 2268 dbSNP
rs534254561 2272 dbSNP
rs1050800079 2273 dbSNP
rs139306479 2274 dbSNP
rs1308162901 2279 dbSNP
rs1348308783 2280 dbSNP
rs1343113299 2283 dbSNP
rs1236235799 2287 dbSNP
rs748164891 2299 dbSNP
rs999350674 2323 dbSNP
rs376121468 2324 dbSNP
rs548394890 2325 dbSNP
rs967896954 2328 dbSNP
rs78125532 2339 dbSNP
rs75638506 2341 dbSNP
rs982996215 2344 dbSNP
rs550698466 2345 dbSNP
rs555420624 2359 dbSNP
rs1465961977 2368 dbSNP
rs1310506871 2376 dbSNP
rs1398002819 2380 dbSNP
rs144399614 2381 dbSNP
rs997744004 2382 dbSNP
rs539827965 2395 dbSNP
rs902077593 2396 dbSNP
rs1442774615 2410 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048188. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_ptb_knockdown ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202476. RNA binding protein: AGO2. Condition:S1_LV_54yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202479. RNA binding protein: AGO2. Condition:S4_LV_29yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ugguCA-ACGGAGAUGUCAGAaau 5'
              || ||: | |::|||||   
Target 5' guguGUGUGUGUGUGUAGUCU--- 3'
6 - 26
Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM1048188
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_ptb_knockdown
Location of target site ENST00000416695.2 | 3UTR | AGUUUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000416695.2 | 3UTR | UAACAGUUUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
94 hsa-miR-7161-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT131193 INCENP inner centromere protein 2 4
MIRT318016 CENPQ centromere protein Q 2 2
MIRT405275 ZNF678 zinc finger protein 678 2 2
MIRT442570 CCDC59 coiled-coil domain containing 59 2 2
MIRT442611 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT444013 GOLGA8H golgin A8 family member H 2 2
MIRT444024 GOLGA8M golgin A8 family member M 2 2
MIRT444339 GOLGA6L4 golgin A6 family-like 4 2 2
MIRT444611 GOLGA6L10 golgin A6 family-like 10 2 2
MIRT446342 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT446558 GOLGA8J golgin A8 family member J 2 2
MIRT447671 PACSIN2 protein kinase C and casein kinase substrate in neurons 2 2 2
MIRT447975 MSH6 mutS homolog 6 2 2
MIRT448895 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT448936 CHD7 chromodomain helicase DNA binding protein 7 2 2
MIRT449414 TRIM5 tripartite motif containing 5 2 2
MIRT450291 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT454877 PCNA proliferating cell nuclear antigen 2 4
MIRT456615 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT462108 TMEM214 transmembrane protein 214 2 2
MIRT471923 NRAS NRAS proto-oncogene, GTPase 2 4
MIRT474437 KLHL21 kelch like family member 21 2 2
MIRT476600 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT480573 BZW1 basic leucine zipper and W2 domains 1 2 2
MIRT483890 IL20RB interleukin 20 receptor subunit beta 2 6
MIRT493363 KIF5B kinesin family member 5B 2 2
MIRT494934 TMEM167A transmembrane protein 167A 2 2
MIRT495915 CLDN1 claudin 1 2 2
MIRT501574 PLEKHF2 pleckstrin homology and FYVE domain containing 2 2 4
MIRT502193 IGF1R insulin like growth factor 1 receptor 2 4
MIRT502928 CDC42SE1 CDC42 small effector 1 2 4
MIRT506393 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 2 4
MIRT506570 MNX1 motor neuron and pancreas homeobox 1 2 4
MIRT509478 GNL3L G protein nucleolar 3 like 2 6
MIRT518537 FLCN folliculin 2 6
MIRT519577 ZNFX1 zinc finger NFX1-type containing 1 2 4
MIRT524088 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 4
MIRT524146 LDHD lactate dehydrogenase D 2 4
MIRT524659 C1orf50 chromosome 1 open reading frame 50 2 10
MIRT526324 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526566 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT526612 ZNF780A zinc finger protein 780A 2 4
MIRT526889 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT527115 ARHGAP15 Rho GTPase activating protein 15 2 2
MIRT528023 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT529589 TMEM220 transmembrane protein 220 2 2
MIRT532797 STYK1 serine/threonine/tyrosine kinase 1 2 2
MIRT537099 GPC6 glypican 6 2 2
MIRT539070 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 2
MIRT545495 DAPK2 death associated protein kinase 2 2 2
MIRT545814 ZNF608 zinc finger protein 608 2 4
MIRT553533 TMEM185B transmembrane protein 185B 2 4
MIRT557285 HIST2H2BE histone cluster 2 H2B family member e 2 2
MIRT559552 ARGLU1 arginine and glutamate rich 1 2 4
MIRT561069 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT561710 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT561995 LRRC58 leucine rich repeat containing 58 2 2
MIRT565896 NHS NHS actin remodeling regulator 2 2
MIRT567333 HMGB1 high mobility group box 1 2 2
MIRT568042 CLDN12 claudin 12 2 2
MIRT568315 BAG4 BCL2 associated athanogene 4 2 2
MIRT570677 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT571047 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT571359 SFT2D2 SFT2 domain containing 2 2 2
MIRT571935 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT572786 ZNF277 zinc finger protein 277 2 2
MIRT573936 CNTNAP2 contactin associated protein like 2 2 2
MIRT576962 Anxa4 annexin A4 2 3
MIRT608297 KATNAL1 katanin catalytic subunit A1 like 1 2 2
MIRT613342 AFF1 AF4/FMR2 family member 1 2 2
MIRT613529 ANAPC7 anaphase promoting complex subunit 7 2 2
MIRT614705 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT616658 ORAI1 ORAI calcium release-activated calcium modulator 1 2 2
MIRT624731 ANXA4 annexin A4 2 3
MIRT626525 TSC1 TSC complex subunit 1 2 2
MIRT627647 SCN1A sodium voltage-gated channel alpha subunit 1 2 2
MIRT637423 EPB41L3 erythrocyte membrane protein band 4.1 like 3 2 2
MIRT641059 TCP11L1 t-complex 11 like 1 2 4
MIRT645591 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT646455 ZNF705A zinc finger protein 705A 2 2
MIRT656454 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT676551 TMPPE transmembrane protein with metallophosphoesterase domain 2 4
MIRT682720 KIAA1456 KIAA1456 2 2
MIRT698307 TMEM2 transmembrane protein 2 2 2
MIRT701906 MMGT1 membrane magnesium transporter 1 2 2
MIRT702228 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT708642 UBE2W ubiquitin conjugating enzyme E2 W 2 2
MIRT709326 HMBOX1 homeobox containing 1 2 2
MIRT711400 RANBP2 RAN binding protein 2 2 2
MIRT712130 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT714226 ARMC10 armadillo repeat containing 10 2 2
MIRT716914 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT723060 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT723846 MN1 MN1 proto-oncogene, transcriptional regulator 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-7161-5p Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer cell line (HEYA8)

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