pre-miRNA Information
pre-miRNA hsa-mir-640   
Genomic Coordinates chr19: 19435063 - 19435158
Synonyms MIRN640, hsa-mir-640, MIR640
Description Homo sapiens miR-640 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-640
Sequence 61| AUGAUCCAGGAACCUGCCUCU |81
Evidence Experimental
Experiments RT-PCR
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30153378 1 COSMIC
COSN23015356 12 COSMIC
COSN30513185 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs111726405 1 dbSNP
rs765622881 2 dbSNP
rs1249744889 6 dbSNP
rs752995186 12 dbSNP
rs758746736 13 dbSNP
rs918887970 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol NPHS1   
Synonyms CNF, NPHN, nephrin
Description NPHS1, nephrin
Transcript NM_004646   
Expression
Putative miRNA Targets on NPHS1
3'UTR of NPHS1
(miRNA target sites are highlighted)
>NPHS1|NM_004646|3'UTR
   1 GAGCCCTCTCAACCCCATTGTCCTGCACCTGCAGGAATTTACACTCCACTGGTCTCTCTCATTACAGCCTGGGCCGAGCT
  81 GGTTAGGTGAGCTCCATAAAACCCAAAGGGACTTGGTGTCAGGAGAGGACATGGAGGGGGCTGAGTGACAGAGATGGTTC
 161 AGCTGGTACCAGAGTAGAAACAAGGTGCATCCTGGGGTTGGCTTTAGAAACTAAACTTCTCCAAAAGGACAGGGCAGATT
 241 GTAAACGTCGTCTCAAAAATGAAATGCTGCCGGGTGCGGTGACTCACGCCTATAATCCCAGCACTTTGGGAGGCTGAGGC
 321 GGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTAAAACTCCATTTCTACTAAAAATATAAAAA
 401 ATTAGCCAGGAGTAGTGGCGCATGCCTGTAGTCCCAGCTACTTGGGAGGCTGATGCATGAGAATTGCTTGAACCCAGGAG
 481 GCGGAGGTTGCAGTGAGCTGAGATCACGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGATTCTGTCTCAAAAAATAAA
 561 AATAAAATAAAAATAAAAAATAAAATGCTATTCTGAGGGTCCCTAAGTGCTTCATGAAGTAAAGTTTTCAGAAGTGGGGA
 641 AAGACATATGAAAAACTCTGTTCATTTTGCATTCCATGACGTCTGAAATAGCTAATAATAAGTGGAATTTATGAATCCAT
 721 GTTGCATCCTACCTATTATTTTATTATTTCCGACAGTTATCTAACACAGGAGGCATAAACTATGACACATGTAAACATAA
 801 GTATGCTCCATAAGCATTAAAATAAACAGACAATCAAAAGAAGCTAGAGGAAAAGAATATGTACTGTGTGTGTGCTTTCG
 881 TTTATAGAAATTCTAAAATAGGCAAAACTAATCTACGGTGGCAGAGAGCACAGCAGAGGTTTCCTGGGGCCATGAGAGGA
 961 GGGTTGACTGCAAAAAGGCATGGGAGAACTTTCTGAGGTGTTGGAAATATTCTATATAACGATTGTGGTGGTGGTTGCAC
1041 GGGTGCACAGATTTGTCAAAACTCATTGAACTTTACACTTAAGATGGGTGCATTTTTATTGTACATAAATGATATCTCAA
1121 TAAAAGTGATTTTAAAAACAGG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucUCCGUCCAAGGACCUAGUa 5'
            ||||:||    ||||||| 
Target 5' tgAGGCGGG----TGGATCAc 3'
315 - 331 157.00 -21.20
2
miRNA  3' ucUCCG--UCCAA-G------GAC-CUAGUa 5'
            ||||  ||||| |      ||| ||||| 
Target 5' ggAGGCGGAGGTTGCAGTGAGCTGAGATCAc 3'
477 - 507 127.00 -17.60
3
miRNA  3' ucUCCGUC-CAAGG-----ACCUAGUa 5'
            :||| | ||  |     ||| ||| 
Target 5' ggGGGCTGAGTGACAGAGATGGTTCAg 3'
136 - 162 111.00 -11.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
56503 10 ClinVar
328852 82 ClinVar
889497 146 ClinVar
328851 250 ClinVar
889495 272 ClinVar
889496 272 ClinVar
891943 287 ClinVar
891942 419 ClinVar
891941 457 ClinVar
891940 483 ClinVar
328850 488 ClinVar
328849 529 ClinVar
328848 538 ClinVar
328847 609 ClinVar
328846 706 ClinVar
890693 751 ClinVar
890692 757 ClinVar
328845 759 ClinVar
890691 760 ClinVar
890690 765 ClinVar
890689 865 ClinVar
890688 888 ClinVar
328844 958 ClinVar
890112 962 ClinVar
328843 1020 ClinVar
328842 1021 ClinVar
328841 1040 ClinVar
890111 1111 ClinVar
328840 1119 ClinVar
COSN31500676 1 COSMIC
COSN31578119 2 COSMIC
COSN30535250 5 COSMIC
COSN30540332 7 COSMIC
COSN31512133 10 COSMIC
COSN30139557 11 COSMIC
COSN30451753 13 COSMIC
COSN30138357 15 COSMIC
COSN26679105 26 COSMIC
COSN30533434 30 COSMIC
COSN31509872 34 COSMIC
COSN32052903 76 COSMIC
COSN26547804 86 COSMIC
COSN28753580 92 COSMIC
COSN30458473 108 COSMIC
COSN30125708 119 COSMIC
COSN30481311 127 COSMIC
COSN31542302 217 COSMIC
COSN9356187 247 COSMIC
COSN21678534 507 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs765462019 1 dbSNP
rs1310154596 4 dbSNP
rs534460381 8 dbSNP
rs386833941 10 dbSNP
rs750056155 10 dbSNP
rs1297855953 12 dbSNP
rs570221002 14 dbSNP
rs1310499856 15 dbSNP
rs1242924828 16 dbSNP
rs761380996 18 dbSNP
rs774466839 19 dbSNP
rs1434712918 20 dbSNP
rs764086013 31 dbSNP
rs762712279 32 dbSNP
rs775372059 33 dbSNP
rs769411662 35 dbSNP
rs1197499700 38 dbSNP
rs746124484 42 dbSNP
rs199585460 45 dbSNP
rs200663197 46 dbSNP
rs1393859627 51 dbSNP
rs1432137179 54 dbSNP
rs961101302 65 dbSNP
rs530440119 68 dbSNP
rs1203179540 71 dbSNP
rs1460736638 75 dbSNP
rs569295487 82 dbSNP
rs959528681 90 dbSNP
rs1301306106 101 dbSNP
rs1034271300 103 dbSNP
rs1001095277 104 dbSNP
rs10402161 111 dbSNP
rs1230512514 125 dbSNP
rs905063363 130 dbSNP
rs551020364 131 dbSNP
rs571218761 131 dbSNP
rs1202098288 137 dbSNP
rs1266873837 140 dbSNP
rs1488590716 141 dbSNP
rs968723338 142 dbSNP
rs1212569012 146 dbSNP
rs73928316 146 dbSNP
rs1451942147 150 dbSNP
rs1189791806 162 dbSNP
rs1009558735 173 dbSNP
rs901933385 174 dbSNP
rs774034614 180 dbSNP
rs1018945881 184 dbSNP
rs562187646 187 dbSNP
rs889600856 188 dbSNP
rs1005434279 193 dbSNP
rs1427145119 194 dbSNP
rs1050045774 195 dbSNP
rs1442886099 202 dbSNP
rs1457563424 205 dbSNP
rs1324041970 226 dbSNP
rs888385510 229 dbSNP
rs1435828458 233 dbSNP
rs540834951 242 dbSNP
rs528627628 246 dbSNP
rs929991772 247 dbSNP
rs901240114 249 dbSNP
rs117894015 250 dbSNP
rs1270821082 262 dbSNP
rs1208770444 266 dbSNP
rs1036689206 271 dbSNP
rs550845716 272 dbSNP
rs1414968340 274 dbSNP
rs1433352140 277 dbSNP
rs757951513 278 dbSNP
rs1194619734 285 dbSNP
rs151204365 287 dbSNP
rs937771550 288 dbSNP
rs942855156 290 dbSNP
rs926787184 292 dbSNP
rs980031531 293 dbSNP
rs968264942 302 dbSNP
rs1304433597 304 dbSNP
rs1379640824 310 dbSNP
rs1413870444 312 dbSNP
rs1291094040 315 dbSNP
rs1021202703 320 dbSNP
rs1228527070 321 dbSNP
rs1282898325 323 dbSNP
rs1315727600 324 dbSNP
rs1234051242 325 dbSNP
rs752308699 339 dbSNP
rs988355220 347 dbSNP
rs563649993 348 dbSNP
rs1018917823 357 dbSNP
rs1254272314 360 dbSNP
rs1473028728 365 dbSNP
rs913499040 366 dbSNP
rs987752833 372 dbSNP
rs956394260 374 dbSNP
rs1035177888 378 dbSNP
rs1359634893 380 dbSNP
rs1007620614 396 dbSNP
rs1310827480 402 dbSNP
rs1433895574 402 dbSNP
rs1351986651 407 dbSNP
rs1410047492 409 dbSNP
rs371174279 410 dbSNP
rs1278500572 411 dbSNP
rs981916588 412 dbSNP
rs1220385297 413 dbSNP
rs1028142337 419 dbSNP
rs1351323835 420 dbSNP
rs1306033930 428 dbSNP
rs1347730844 431 dbSNP
rs995778850 431 dbSNP
rs898411317 434 dbSNP
rs1390980795 439 dbSNP
rs764907684 442 dbSNP
rs939926942 454 dbSNP
rs113978942 457 dbSNP
rs1023445360 459 dbSNP
rs1056550972 464 dbSNP
rs1005404474 466 dbSNP
rs1413058437 474 dbSNP
rs781233146 482 dbSNP
rs199649890 483 dbSNP
rs886054346 488 dbSNP
rs1174881281 495 dbSNP
rs1395672586 499 dbSNP
rs979622958 503 dbSNP
rs574666033 505 dbSNP
rs1442912149 507 dbSNP
rs914079908 508 dbSNP
rs1362355020 509 dbSNP
rs988325708 511 dbSNP
rs1158847817 514 dbSNP
rs966287250 515 dbSNP
rs1018930139 517 dbSNP
rs1252267340 519 dbSNP
rs986567139 523 dbSNP
rs148755697 529 dbSNP
rs534840613 530 dbSNP
rs71354105 538 dbSNP
rs190531981 541 dbSNP
rs1300373021 545 dbSNP
rs901207967 552 dbSNP
rs536727970 565 dbSNP
rs10401159 566 dbSNP
rs962501995 574 dbSNP
rs1271179155 579 dbSNP
rs1453525294 584 dbSNP
rs1015448938 585 dbSNP
rs1252441501 595 dbSNP
rs1484861023 596 dbSNP
rs144206206 609 dbSNP
rs889885254 620 dbSNP
rs1043177001 634 dbSNP
rs548161304 638 dbSNP
rs535834634 640 dbSNP
rs530846663 645 dbSNP
rs538434487 646 dbSNP
rs1406709632 650 dbSNP
rs1326063905 656 dbSNP
rs1393113508 658 dbSNP
rs768569444 658 dbSNP
rs1437994792 660 dbSNP
rs1309482052 662 dbSNP
rs1327479285 671 dbSNP
rs913467954 674 dbSNP
rs1056119673 676 dbSNP
rs568742374 680 dbSNP
rs763154546 681 dbSNP
rs562833899 685 dbSNP
rs1272721779 686 dbSNP
rs1467201504 690 dbSNP
rs1210629130 702 dbSNP
rs80296922 706 dbSNP
rs946483141 712 dbSNP
rs1192254715 719 dbSNP
rs1288610618 724 dbSNP
rs914050481 725 dbSNP
rs1454667387 726 dbSNP
rs1365171551 729 dbSNP
rs1165200644 736 dbSNP
rs1052577530 738 dbSNP
rs549430502 751 dbSNP
rs912162547 752 dbSNP
rs986145513 754 dbSNP
rs552731597 757 dbSNP
rs886054345 759 dbSNP
rs531569980 760 dbSNP
rs1342655151 765 dbSNP
rs973455647 767 dbSNP
rs531022050 768 dbSNP
rs1332893841 772 dbSNP
rs1015417622 775 dbSNP
rs1268819831 776 dbSNP
rs1351396847 787 dbSNP
rs1204492624 789 dbSNP
rs1259979939 790 dbSNP
rs1261005404 797 dbSNP
rs1443958185 800 dbSNP
rs770201529 803 dbSNP
rs952563207 805 dbSNP
rs1205483403 807 dbSNP
rs1025559795 808 dbSNP
rs960654829 814 dbSNP
rs1211984188 820 dbSNP
rs994051748 827 dbSNP
rs1035311054 831 dbSNP
rs563572189 846 dbSNP
rs1002134836 858 dbSNP
rs965678751 863 dbSNP
rs904828636 865 dbSNP
rs866617351 869 dbSNP
rs576056388 880 dbSNP
rs745654494 888 dbSNP
rs1325164747 889 dbSNP
rs542215551 892 dbSNP
rs1010595839 893 dbSNP
rs139488784 895 dbSNP
rs146296157 907 dbSNP
rs1211379378 912 dbSNP
rs187198869 916 dbSNP
rs912065165 917 dbSNP
rs1051079021 946 dbSNP
rs1206873799 948 dbSNP
rs1250713489 949 dbSNP
rs938906859 953 dbSNP
rs1324320391 954 dbSNP
rs886054344 958 dbSNP
rs928896198 959 dbSNP
rs1460548620 963 dbSNP
rs1173479275 966 dbSNP
rs576656652 976 dbSNP
rs1046053908 979 dbSNP
rs780788401 1000 dbSNP
rs1474169981 1005 dbSNP
rs916331022 1006 dbSNP
rs1303456279 1009 dbSNP
rs1373182576 1016 dbSNP
rs564256430 1020 dbSNP
rs536792618 1021 dbSNP
rs962107353 1033 dbSNP
rs1430242042 1034 dbSNP
rs1193615016 1036 dbSNP
rs778092711 1036 dbSNP
rs907991252 1036 dbSNP
rs181405524 1040 dbSNP
rs972581445 1041 dbSNP
rs965293990 1049 dbSNP
rs1451742448 1062 dbSNP
rs992915895 1067 dbSNP
rs1468169028 1071 dbSNP
rs1372759265 1078 dbSNP
rs1460652775 1081 dbSNP
rs960789466 1087 dbSNP
rs554324381 1093 dbSNP
rs981073615 1100 dbSNP
rs373820113 1104 dbSNP
rs746875090 1105 dbSNP
rs535877689 1109 dbSNP
rs777800161 1111 dbSNP
rs1010564413 1116 dbSNP
rs1021656899 1116 dbSNP
rs74509387 1119 dbSNP
rs1216164917 1120 dbSNP
rs1295992340 1123 dbSNP
rs1030667734 1124 dbSNP
rs1008652732 1142 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084040. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep1 HITS-CLIP data was present in GSM1084042. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep2 HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_004646 | 3UTR | GCUGAGGCGGGUGGAUCACCUGAGGUCAGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_004646 | 3UTR | GAGGCGGGUGGAUCACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_004646 | 3UTR | GGCUGAGGCGGGUGGAUCACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_004646 | 3UTR | CUGAGGCGGGUGGAUCACCUGAGGUCAGGAGUUCGAGACCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084040
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep1
Location of target site ENST00000378910.5 | 3UTR | GGAGGCUGAGGCGGGUGGAUCACCUGAGGUCAGGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084042
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep2
Location of target site ENST00000378910.5 | 3UTR | GGGAGGCUGAGGCGGGUGGAUCACCUGAGGUCAGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000378910.5 | 3UTR | GAGGCUGAGGCGGGUGGAUCACCUGAGGUCAGGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE32688 Pancreatic cancer 0.58 2.5e-4 0.569 3.4e-4 32 Click to see details
GSE19350 CNS germ cell tumors 0.648 1.1e-2 0.252 2.1e-1 12 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.4 2.4e-2 -0.160 2.2e-1 25 Click to see details
GSE19783 ER+ ER+ breast cancer 0.443 2.5e-2 -0.054 4.1e-1 20 Click to see details
GSE17498 Multiple myeloma -0.306 2.7e-2 -0.278 4.1e-2 40 Click to see details
GSE19536 Breast cancer 0.189 3.0e-2 0.189 3.0e-2 100 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.321 8.4e-2 -0.209 1.9e-1 20 Click to see details
GSE17306 Multiple myeloma 0.2 8.4e-2 0.157 1.4e-1 49 Click to see details
GSE38226 Liver fibrosis -0.301 9.2e-2 -0.169 2.3e-1 21 Click to see details
GSE28260 Renal cortex and medulla -0.36 1.1e-1 -0.367 1.1e-1 13 Click to see details
GSE26953 Aortic valvular endothelial cells 0.229 1.4e-1 0.071 3.7e-1 24 Click to see details
GSE19783 ER- ER- breast cancer 0.098 2.0e-1 0.168 6.9e-2 79 Click to see details
GSE28544 Breast cancer -0.151 2.4e-1 -0.074 3.7e-1 24 Click to see details
GSE27834 Pluripotent stem cells 0.169 2.7e-1 0.262 1.6e-1 16 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.129 2.7e-1 0.184 1.9e-1 25 Click to see details
GSE14794 Lymphoblastoid cells -0.031 3.9e-1 -0.024 4.1e-1 90 Click to see details
GSE21849 B cell lymphoma -0.04 4.2e-1 0.083 3.3e-1 29 Click to see details
GSE21687 Ependynoma primary tumors 0.017 4.5e-1 0.011 4.7e-1 64 Click to see details
GSE42095 Differentiated embryonic stem cells 0.011 4.8e-1 0.000 5.0e-1 23 Click to see details
GSE42095 Differentiated embryonic stem cells 0.011 4.8e-1 0.000 5.0e-1 23 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
194 hsa-miR-640 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT097121 TNPO1 transportin 1 2 2
MIRT115090 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 4
MIRT204603 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204634 MOB4 MOB family member 4, phocein 2 8
MIRT344451 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT405772 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT445876 SENP6 SUMO1/sentrin specific peptidase 6 2 2
MIRT497418 FAM46A family with sequence similarity 46 member A 2 2
MIRT504394 HMX2 H6 family homeobox 2 2 4
MIRT504691 SLCO2B1 solute carrier organic anion transporter family member 2B1 2 8
MIRT512386 MTRNR2L3 MT-RNR2-like 3 2 6
MIRT513003 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT513084 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT519122 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT523836 F2RL1 F2R like trypsin receptor 1 2 2
MIRT565356 TMCC1 transmembrane and coiled-coil domain family 1 2 2
MIRT575895 Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT576894 Poteg POTE ankyrin domain family, member G 2 2
MIRT613780 RPS6 ribosomal protein S6 2 2
MIRT613934 POLR3A RNA polymerase III subunit A 2 2
MIRT614348 LOH12CR1 BLOC-1 related complex subunit 5 2 2
MIRT614534 NOA1 nitric oxide associated 1 2 2
MIRT617019 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT618247 MANEAL mannosidase endo-alpha like 2 2
MIRT619051 TTC4 tetratricopeptide repeat domain 4 2 2
MIRT619442 ZNF517 zinc finger protein 517 2 2
MIRT619723 FPR2 formyl peptide receptor 2 2 2
MIRT620179 TRIM72 tripartite motif containing 72 2 2
MIRT620370 ANKRD62 ankyrin repeat domain 62 2 2
MIRT621263 RTN2 reticulon 2 2 2
MIRT621463 APOH apolipoprotein H 2 2
MIRT621571 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT621683 TSPYL1 TSPY like 1 2 2
MIRT622866 PDE7A phosphodiesterase 7A 2 2
MIRT624669 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT625607 ZNF84 zinc finger protein 84 2 2
MIRT626111 IL23R interleukin 23 receptor 2 2
MIRT628380 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT628553 MELK maternal embryonic leucine zipper kinase 2 2
MIRT628671 C2orf72 chromosome 2 open reading frame 72 2 2
MIRT628747 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT628776 TMEM154 transmembrane protein 154 2 2
MIRT628918 ZNF430 zinc finger protein 430 2 2
MIRT629174 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT629209 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629267 SLC5A8 solute carrier family 5 member 8 2 2
MIRT629498 AS3MT arsenite methyltransferase 2 2
MIRT629665 USP1 ubiquitin specific peptidase 1 2 2
MIRT629760 STK25 serine/threonine kinase 25 2 2
MIRT630899 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT631105 SLC15A2 solute carrier family 15 member 2 2 2
MIRT631112 ATCAY ATCAY, caytaxin 2 2
MIRT631450 DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 2 2
MIRT631505 FFAR4 free fatty acid receptor 4 2 2
MIRT631580 ITGAL integrin subunit alpha L 2 2
MIRT631836 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT632342 SWSAP1 SWIM-type zinc finger 7 associated protein 1 2 2
MIRT633214 ZNF584 zinc finger protein 584 2 2
MIRT633223 ZNF43 zinc finger protein 43 2 2
MIRT633480 ARIH2OS ariadne RBR E3 ubiquitin protein ligase 2 opposite strand 2 2
MIRT633511 LRRC27 leucine rich repeat containing 27 2 2
MIRT633615 CWF19L1 CWF19 like 1, cell cycle control (S. pombe) 2 2
MIRT633652 SLC28A1 solute carrier family 28 member 1 2 2
MIRT633677 ZNF576 zinc finger protein 576 2 2
MIRT634196 TMOD2 tropomodulin 2 2 4
MIRT634388 PLSCR1 phospholipid scramblase 1 2 2
MIRT635817 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT635962 TTC31 tetratricopeptide repeat domain 31 2 2
MIRT636114 YPEL1 yippee like 1 2 2
MIRT636164 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636768 CLUAP1 clusterin associated protein 1 2 2
MIRT637092 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637316 FAM9B family with sequence similarity 9 member B 2 2
MIRT637540 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637628 ZNF431 zinc finger protein 431 2 2
MIRT637826 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT637945 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT637968 IRF1 interferon regulatory factor 1 2 2
MIRT638321 RNF11 ring finger protein 11 2 2
MIRT638386 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT639244 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT642608 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT642793 SLC1A5 solute carrier family 1 member 5 2 2
MIRT643847 LACTB lactamase beta 2 4
MIRT644705 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT645148 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT646671 CCDC69 coiled-coil domain containing 69 2 2
MIRT647780 ASB8 ankyrin repeat and SOCS box containing 8 2 2
MIRT648554 WDR92 WD repeat domain 92 2 2
MIRT648990 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT649099 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT650141 ZNF426 zinc finger protein 426 2 2
MIRT650791 GSR glutathione-disulfide reductase 2 2
MIRT654967 PLEKHA2 pleckstrin homology domain containing A2 2 2
MIRT655099 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT655516 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT656289 METTL14 methyltransferase like 14 2 2
MIRT656497 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657074 JPH2 junctophilin 2 2 2
MIRT657314 HOOK3 hook microtubule tethering protein 3 2 2
MIRT657419 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT659032 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659535 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT661532 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT662029 FUT2 fucosyltransferase 2 2 2
MIRT663206 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663357 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT663557 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663650 POLM DNA polymerase mu 2 2
MIRT663694 ABHD17B abhydrolase domain containing 17B 2 2
MIRT664370 CYB5A cytochrome b5 type A 2 2
MIRT664783 LIAS lipoic acid synthetase 2 4
MIRT665561 TXNL1 thioredoxin like 1 2 2
MIRT665950 TAOK1 TAO kinase 1 2 2
MIRT667338 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT667804 ITIH5 inter-alpha-trypsin inhibitor heavy chain family member 5 2 2
MIRT668804 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT669470 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT669599 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT669806 STOML1 stomatin like 1 2 2
MIRT669944 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT670292 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670381 EMP2 epithelial membrane protein 2 2 2
MIRT670481 DCUN1D2 defective in cullin neddylation 1 domain containing 2 2 2
MIRT670531 KIF1C kinesin family member 1C 2 4
MIRT670565 GLTP glycolipid transfer protein 2 2
MIRT670603 NPHP1 nephrocystin 1 2 2
MIRT670880 CYTIP cytohesin 1 interacting protein 2 2
MIRT670931 LIPG lipase G, endothelial type 2 2
MIRT671261 MTRNR2L5 MT-RNR2-like 5 2 2
MIRT671794 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT671897 GBP4 guanylate binding protein 4 2 2
MIRT672000 SLC35F6 solute carrier family 35 member F6 2 4
MIRT672074 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT672319 C9orf3 chromosome 9 open reading frame 3 2 2
MIRT672853 C22orf29 retrotransposon Gag like 10 2 2
MIRT673395 WNT7B Wnt family member 7B 2 2
MIRT673537 DEGS1 delta 4-desaturase, sphingolipid 1 2 2
MIRT674285 ZNF724P zinc finger protein 724 2 2
MIRT674494 TIRAP TIR domain containing adaptor protein 2 2
MIRT675460 NUBPL nucleotide binding protein like 2 2
MIRT675569 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT676068 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676254 PBOV1 prostate and breast cancer overexpressed 1 2 2
MIRT676377 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676758 SNX2 sorting nexin 2 2 2
MIRT676773 NPHS1 NPHS1, nephrin 2 2
MIRT676874 ENSA endosulfine alpha 2 2
MIRT676918 KLHDC8A kelch domain containing 8A 2 2
MIRT676944 S1PR3 sphingosine-1-phosphate receptor 3 2 2
MIRT676957 HFE hemochromatosis 2 2
MIRT676967 RNF19B ring finger protein 19B 2 2
MIRT676972 ZNF708 zinc finger protein 708 2 2
MIRT677042 ZNF34 zinc finger protein 34 2 2
MIRT677070 VMAC vimentin type intermediate filament associated coiled-coil protein 2 2
MIRT677093 MFSD11 major facilitator superfamily domain containing 11 2 4
MIRT677134 P2RX7 purinergic receptor P2X 7 2 2
MIRT677179 ZNF786 zinc finger protein 786 2 2
MIRT677228 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677320 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT677455 PDLIM3 PDZ and LIM domain 3 2 2
MIRT677809 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT677937 ZNF519 zinc finger protein 519 2 2
MIRT678063 UBN2 ubinuclein 2 2 4
MIRT678072 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678252 FXN frataxin 2 2
MIRT678315 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678367 XIAP X-linked inhibitor of apoptosis 2 4
MIRT678372 RNF115 ring finger protein 115 2 2
MIRT678410 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678518 ZNF347 zinc finger protein 347 2 2
MIRT678566 CDK4 cyclin dependent kinase 4 2 2
MIRT678580 PPP1R3B protein phosphatase 1 regulatory subunit 3B 2 2
MIRT678820 PDE6A phosphodiesterase 6A 2 2
MIRT678917 XPOT exportin for tRNA 2 2
MIRT679217 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679437 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT679595 HILPDA hypoxia inducible lipid droplet associated 2 2
MIRT679755 TLR6 toll like receptor 6 2 2
MIRT679800 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 2 2
MIRT680057 CD96 CD96 molecule 2 2
MIRT680116 CCDC30 coiled-coil domain containing 30 2 4
MIRT680181 ZNF554 zinc finger protein 554 2 2
MIRT680439 WDR12 WD repeat domain 12 2 2
MIRT680789 ZNF578 zinc finger protein 578 2 2
MIRT692464 APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2 2 2
MIRT702952 HIP1 huntingtin interacting protein 1 2 2
MIRT706016 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT706032 F2R coagulation factor II thrombin receptor 2 2
MIRT706135 MTRNR2L10 MT-RNR2-like 10 2 2
MIRT706394 HAS2 hyaluronan synthase 2 2 2
MIRT713293 DCP2 decapping mRNA 2 2 2
MIRT716583 BRAP BRCA1 associated protein 2 2
MIRT720433 C19orf47 chromosome 19 open reading frame 47 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-640 Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer tissue and cell line (SKOV3)
hsa-miR-640 Cetuximab resistant High Colon Cancer cell line
hsa-miR-640 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Mitoxantrone 4212 NSC279836 approved resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-640 Sorafenib 216239 NSC747971 approved sensitive Low Clear Cell Renal Cell Carcinoma cell line (786-O)
hsa-mir-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-640 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-640 Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-640 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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