pre-miRNA Information
pre-miRNA hsa-mir-1245a   
Genomic Coordinates chr2: 188978092 - 188978161
Description Homo sapiens miR-1245a stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1245a
Sequence 45| AAGUGAUCUAAAGGCCUACAU |65
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31562560 15 COSMIC
COSN26581044 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs906938680 2 dbSNP
rs1159117523 3 dbSNP
rs780486044 6 dbSNP
rs771479866 17 dbSNP
rs1002976932 18 dbSNP
rs1428029219 19 dbSNP
Putative Targets

Gene Information
Gene Symbol ENSA   
Synonyms ARPP-19e
Description endosulfine alpha
Transcript NM_207043   
Other Transcripts NM_207042 , NM_004436 , NM_207044 , NM_207045 , NM_207046 , NM_207047 , NM_207168   
Expression
Putative miRNA Targets on ENSA
3'UTR of ENSA
(miRNA target sites are highlighted)
>ENSA|NM_207043|3'UTR
   1 CCTGAGCCCCCCTCTCCTCCCCTTCCTCAACCACTGGACGTTTATATATTATAGGCAGGGATGAAATGGGCACCTAGTCA
  81 GATCTTCTCAGCTTGCTAGCCAGAAATGACTGTGATTCTGCTGGGGGCTGCTGAGAAGGTAATGTAGGTTGAAAAGGGGC
 161 TCTAAGTTTATTTATTTCGTTAGATTGACACTTCCACACACTCCCTGTAGTCCAGGTAGGGCCCAGAAATAGGAAAGGCT
 241 AGGATTGGATAATGCTGCAAATGCTTTTTTTGTGTGAGAAACTGGAGAGATGTGATTTCTCCTTTTGGGAGAGAATGTCC
 321 CAAAATTGATTAGGCTGAGCCTTGGGAATAGTTTGGCAGGTTTAACATCCCAAGGCTAACCTAACGTAGTTGGGAAAGGT
 401 AGATTGAATGAGACATGTTTTCTGTGCTTCTAAGTGTTCTGTCCCTTAGGCTGCTATTGCTTCATGTTTCCATTATGGCA
 481 GGTTTAGAGAATCCTTAAAAAGAAAAATTGACTTGCTTGCCTAAAACTACAGTGCCCCCTTAGCCTCCATTACTTAGTAT
 561 CTCTTACAGTTTGCTCTGGCTCTCAAATAATATAAAGATTGATGAACATTATTCACAGAAAATGGGCACCTTCTCTCTCT
 641 CTTCCAGCATGTTGCTTTTGAAAGTATCATGGGATAGTGGGACGAGCACTGGTTTAGGAGTCAAGATATCTGGGTTCTCA
 721 CTCTACTCAGTCCCAGCAGAGCTGTTGTATAACCTTGATTAAGTCATTTAGCCTCTCTGGATTTCTATTTCCTCATCTGT
 801 AAAATAGAGTTAAATGTATGTAAGATTGATTCTGATTCTGAAGTCTTAACTGCCAGCAGAAAAACTCCATACTGTTCATT
 881 GTAAAACTAAAAGTGAGGAAGGCTCGTGGGTGGTGAACCTCTGCTCTGTAATACTGGGAAAGTACTACAGAGGGGAACCA
 961 TTTGAGGGATACATGAGGAGAGAGTAAATTGAGGTTTGGGGATTATAAATTCAGGCAAGAGAACCTTATAGATATCACAG
1041 TCTTGAGGGTCAAAAAAAAATACTTAGGAAGCTAGCCATGGAAGCTTCTTGCCTCTGACCCAGCCCACTTTCCCAGCCTA
1121 CCTCTGGGCCTTAGCTGCTAAAAAGCTTCTCTGGCAGCGGAGCTGCAGGCCTGAGGAAACATGCTCAGTCATGCACATGT
1201 GTTGACCCATGTTTCAGATGCAGTCTGATGCCAGGTATATTGTTAGGGAAAGAGGAAGAAGGGTAAACTGAGCTAGCCCC
1281 TGGGGCTGAGTACTCCTGCAGGGCTGGAGGAACAGGTTCTTAGAAGATGATTCACCTTGGAGGAAGCTGGGGAAAGTGGT
1361 TAGGGAGGGAGAGGAGGAAGACTGAGAAATCTCTGCATCCCCAGAACTCAGCAACCCAGCTCTTTTATCATGAGGAGAGG
1441 TAGCCATGCTGACTCATGAACAGGTGGAGGAAAGGGGTTGCAGGTGACCAGCATCTTCAATCTAGTTACCACCAGCTTGG
1521 CTAGAATTTTATTGAACGCAACTTGCTAGTTATGACAGAGAGGACCAGGGTGAGAACTAATGCTCAAGAGAGCAAGATTC
1601 TGTAATCCTCTTGCCCTCTCACATCACAAATTCTGATATGCCAAACATTTGGCCCAATGAGAATGACTGATAGACTTGCT
1681 GATGTGCATGTGGGGGGATGAGGTGTGTATATGCCTTTCTCCTGACTGGCCATTCAGTGTTCAGGCTGTCATTCAAATTG
1761 GATAGGAGAAAGTTGGTGAGGAAGGAATGGAGAGAGCAGGATCCCTGGACTCCCTGGTCCCCAAACTCCTTGACTGTCAC
1841 TTGTAATTGTATATAATTTTTGTGTTTCTTGCTCCATTTCCTCATGCTGTCATCCTTAAAGTCCATCTGGGAAGGGGAAA
1921 ATGCTGAACACCATTGTATAGTTTCTTCAACTGTCCCAGCCATGTTGTACATAGATATGTCATGTTATTATATATATAAA
2001 TATATATATAATTTTGTACGTTTTCTTCATCTCCGATCTTCTCAAATTCTGTACTTTTTTTCTTTTCTGTCTGAGCTGCC
2081 TTCTCTATCATTCAGCTTGAGTCCTCAAGACTACTGGTCACAATGAGTCTGATTTTTAGGAAGGAATAGGAGGAGCAGGG
2161 AAATCAGAAAAACTGTTGGTCTCACTCTGTCTCTCTACCTGGTCATCTTCAAGGCTAAGAAAACAAACAAGCTACATTCT
2241 GTATTTGCCAGTTTCCACAGCATGAAGTACATAGCTTCCTTAGCAAGGAGTGGTCATTCCAAAATCCAAATGCAAATTGC
2321 TTTGATTAAACCTAGATTATTAAATCCATTCAGAACAGCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uacAUCCGGAAAUCUAGUGAa 5'
             ||  ||  |||||:|:| 
Target 5' gatTAAACC--TAGATTATTa 3'
2324 - 2342 122.00 -7.90
2
miRNA  3' uaCAUCCGGAAAUCUAGUGAa 5'
            ||:|| |    || |||| 
Target 5' taGTGGGAC----GAGCACTg 3'
675 - 691 117.00 -8.50
3
miRNA  3' uacAUCCGGAAAUCUA---GUGAa 5'
             ||  :| ||||||   |||| 
Target 5' attTATTTCGTTAGATTGACACTt 3'
170 - 193 114.00 -6.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM9819071 5 COSMIC
COSN31596722 6 COSMIC
COSN30190252 12 COSMIC
COSN32123623 14 COSMIC
COSN17078562 25 COSMIC
COSN30143228 55 COSMIC
COSN30515006 60 COSMIC
COSN15102065 151 COSMIC
COSN16188019 178 COSMIC
COSN31543440 253 COSMIC
COSN27794709 685 COSMIC
COSN1405782 1051 COSMIC
COSN31589223 1085 COSMIC
COSN30161847 1155 COSMIC
COSN30161492 1159 COSMIC
COSN15614700 1370 COSMIC
COSN20095353 1390 COSMIC
COSN9363125 1837 COSMIC
COSN31522397 1856 COSMIC
COSN31528155 1860 COSMIC
COSN27162014 2319 COSMIC
rs1971378 853 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1266372171 1 dbSNP
rs745693911 6 dbSNP
rs367689257 7 dbSNP
rs757171377 8 dbSNP
rs1394593978 10 dbSNP
rs753837481 11 dbSNP
rs1321764896 13 dbSNP
rs750966911 14 dbSNP
rs1385777828 18 dbSNP
rs777078545 20 dbSNP
rs755659410 21 dbSNP
rs765707789 23 dbSNP
rs1196782229 25 dbSNP
rs1270122107 29 dbSNP
rs1436961126 30 dbSNP
rs752239839 31 dbSNP
rs767225802 34 dbSNP
rs759307017 36 dbSNP
rs750798198 37 dbSNP
rs587619112 39 dbSNP
rs587741996 40 dbSNP
rs777283764 41 dbSNP
rs1171004166 45 dbSNP
rs768563248 46 dbSNP
rs1422426928 50 dbSNP
rs775536016 50 dbSNP
rs1267387667 52 dbSNP
rs772314823 53 dbSNP
rs1391373155 55 dbSNP
rs1017605596 56 dbSNP
rs1386209538 71 dbSNP
rs1477715647 71 dbSNP
rs1240812847 79 dbSNP
rs1328032638 82 dbSNP
rs1218531909 89 dbSNP
rs985945805 92 dbSNP
rs1279114934 98 dbSNP
rs587662361 101 dbSNP
rs1216888334 109 dbSNP
rs951853539 118 dbSNP
rs1357134053 120 dbSNP
rs1209825612 122 dbSNP
rs1288319596 124 dbSNP
rs1489496095 130 dbSNP
rs1194785785 132 dbSNP
rs191186947 133 dbSNP
rs749947307 134 dbSNP
rs1320898925 141 dbSNP
rs1189187568 147 dbSNP
rs1368601804 155 dbSNP
rs35031758 156 dbSNP
rs587715685 164 dbSNP
rs781072684 165 dbSNP
rs587638398 170 dbSNP
rs1053731 174 dbSNP
rs1461802415 175 dbSNP
rs1161433941 178 dbSNP
rs1284814207 178 dbSNP
rs1420103076 179 dbSNP
rs1297290707 182 dbSNP
rs757808438 187 dbSNP
rs1340124289 188 dbSNP
rs867278318 194 dbSNP
rs747437375 196 dbSNP
rs897733343 199 dbSNP
rs1268253832 201 dbSNP
rs747899840 216 dbSNP
rs1356404120 218 dbSNP
rs1432772903 219 dbSNP
rs1053732 224 dbSNP
rs587706257 225 dbSNP
rs1201873840 229 dbSNP
rs758668505 230 dbSNP
rs1468312676 243 dbSNP
rs1003169933 245 dbSNP
rs1408520625 248 dbSNP
rs1382110608 252 dbSNP
rs1440162658 256 dbSNP
rs1157967958 257 dbSNP
rs1358448244 277 dbSNP
rs904958193 282 dbSNP
rs587650788 286 dbSNP
rs1044807211 291 dbSNP
rs1177448554 293 dbSNP
rs1395543319 301 dbSNP
rs1332205227 311 dbSNP
rs1409658029 313 dbSNP
rs1417773529 326 dbSNP
rs1241581212 339 dbSNP
rs35730518 342 dbSNP
rs1188724032 348 dbSNP
rs946433576 350 dbSNP
rs893330405 353 dbSNP
rs1256250668 357 dbSNP
rs587751580 385 dbSNP
rs115879718 388 dbSNP
rs1457811086 392 dbSNP
rs1177990583 393 dbSNP
rs866574270 395 dbSNP
rs1378365661 396 dbSNP
rs764866980 397 dbSNP
rs1176453853 399 dbSNP
rs1264568407 400 dbSNP
rs1203886966 417 dbSNP
rs1378433774 417 dbSNP
rs1334957786 429 dbSNP
rs924855493 432 dbSNP
rs768154311 443 dbSNP
rs587616642 444 dbSNP
rs976493302 454 dbSNP
rs1270617773 461 dbSNP
rs587770168 464 dbSNP
rs34859086 472 dbSNP
rs944701077 473 dbSNP
rs1371749845 476 dbSNP
rs900385817 483 dbSNP
rs1053646698 486 dbSNP
rs936311551 502 dbSNP
rs75791350 508 dbSNP
rs587685079 516 dbSNP
rs1314302430 527 dbSNP
rs910650082 529 dbSNP
rs986208904 530 dbSNP
rs1230678054 543 dbSNP
rs34541895 549 dbSNP
rs1259560149 552 dbSNP
rs952112027 557 dbSNP
rs587634147 561 dbSNP
rs1197409097 569 dbSNP
rs1027479452 574 dbSNP
rs1489386693 575 dbSNP
rs587754457 576 dbSNP
rs118186764 587 dbSNP
rs962271899 599 dbSNP
rs1441744691 602 dbSNP
rs1353031512 605 dbSNP
rs1431211740 626 dbSNP
rs1174602497 627 dbSNP
rs1426003910 634 dbSNP
rs1172911510 643 dbSNP
rs879778646 644 dbSNP
rs1410881039 673 dbSNP
rs1034919992 676 dbSNP
rs1459958259 680 dbSNP
rs587637921 683 dbSNP
rs1162250983 684 dbSNP
rs1403455350 685 dbSNP
rs1003631829 690 dbSNP
rs1244417110 719 dbSNP
rs587766377 720 dbSNP
rs75075738 721 dbSNP
rs1183739914 722 dbSNP
rs1217491220 726 dbSNP
rs1255684699 727 dbSNP
rs1480099819 728 dbSNP
rs1230834336 730 dbSNP
rs904886130 737 dbSNP
rs587673973 738 dbSNP
rs1023285434 739 dbSNP
rs1010696905 741 dbSNP
rs1487401514 743 dbSNP
rs1290824036 747 dbSNP
rs1243638882 754 dbSNP
rs1361585689 771 dbSNP
rs1315799640 775 dbSNP
rs1223302021 779 dbSNP
rs753418823 782 dbSNP
rs587597954 785 dbSNP
rs1423149230 786 dbSNP
rs868526688 787 dbSNP
rs773004435 791 dbSNP
rs1399079344 793 dbSNP
rs1268026470 794 dbSNP
rs1380767755 796 dbSNP
rs766545438 810 dbSNP
rs1443326590 812 dbSNP
rs1365321439 820 dbSNP
rs144160322 832 dbSNP
rs373955266 833 dbSNP
rs903453536 838 dbSNP
rs763852270 842 dbSNP
rs1971378 853 dbSNP
rs1216224335 861 dbSNP
rs944940907 868 dbSNP
rs1473832993 877 dbSNP
rs910577886 887 dbSNP
rs1413716532 889 dbSNP
rs1443402160 902 dbSNP
rs1164798136 906 dbSNP
rs1381377197 931 dbSNP
rs749196509 948 dbSNP
rs1419453547 949 dbSNP
rs186736317 952 dbSNP
rs1418005077 968 dbSNP
rs587706412 977 dbSNP
rs1360487210 978 dbSNP
rs1405298850 981 dbSNP
rs1301684060 984 dbSNP
rs986086416 988 dbSNP
rs182083095 989 dbSNP
rs930736528 991 dbSNP
rs1352766180 1000 dbSNP
rs1282444289 1012 dbSNP
rs920639505 1023 dbSNP
rs587648697 1024 dbSNP
rs972325563 1031 dbSNP
rs1242675556 1034 dbSNP
rs1220051343 1035 dbSNP
rs961874624 1045 dbSNP
rs1181102372 1049 dbSNP
rs1381434055 1051 dbSNP
rs141928183 1060 dbSNP
rs1426836392 1061 dbSNP
rs927773824 1061 dbSNP
rs587751720 1062 dbSNP
rs982072114 1063 dbSNP
rs772075532 1067 dbSNP
rs1403325290 1078 dbSNP
rs1448309925 1081 dbSNP
rs1215107221 1085 dbSNP
rs111962711 1088 dbSNP
rs745633901 1096 dbSNP
rs1023342558 1097 dbSNP
rs1276323267 1099 dbSNP
rs145047562 1100 dbSNP
rs142896422 1107 dbSNP
rs1030729369 1112 dbSNP
rs1200553706 1118 dbSNP
rs1345192185 1123 dbSNP
rs1239335015 1133 dbSNP
rs1281757964 1146 dbSNP
rs999443451 1148 dbSNP
rs1180282705 1151 dbSNP
rs1248876241 1155 dbSNP
rs1407162713 1158 dbSNP
rs1366662309 1159 dbSNP
rs1190312108 1162 dbSNP
rs903381577 1171 dbSNP
rs1466749121 1173 dbSNP
rs1288831190 1176 dbSNP
rs1040924428 1178 dbSNP
rs767399394 1181 dbSNP
rs1399459750 1186 dbSNP
rs1408200539 1189 dbSNP
rs1009143408 1197 dbSNP
rs1331513630 1210 dbSNP
rs1435450644 1212 dbSNP
rs189503757 1218 dbSNP
rs889331836 1242 dbSNP
rs1220549437 1252 dbSNP
rs1258874786 1262 dbSNP
rs1338813376 1264 dbSNP
rs1194636731 1267 dbSNP
rs1050388812 1269 dbSNP
rs1452580509 1278 dbSNP
rs930620433 1285 dbSNP
rs1266342845 1289 dbSNP
rs761693369 1291 dbSNP
rs781095753 1292 dbSNP
rs1478557661 1300 dbSNP
rs1193925187 1307 dbSNP
rs920691707 1338 dbSNP
rs1160740870 1342 dbSNP
rs1164967925 1345 dbSNP
rs1058183 1347 dbSNP
rs1391308241 1352 dbSNP
rs1404565766 1359 dbSNP
rs1300990151 1367 dbSNP
rs1362216193 1369 dbSNP
rs1402146161 1374 dbSNP
rs1036475480 1381 dbSNP
rs1325968832 1385 dbSNP
rs1472704111 1385 dbSNP
rs1428180805 1391 dbSNP
rs1196934554 1392 dbSNP
rs140626441 1395 dbSNP
rs74891620 1395 dbSNP
rs1267911360 1401 dbSNP
rs1216940523 1402 dbSNP
rs1260560950 1418 dbSNP
rs1444807011 1432 dbSNP
rs1185839968 1433 dbSNP
rs1368991836 1444 dbSNP
rs111543978 1448 dbSNP
rs1444005244 1452 dbSNP
rs927856511 1453 dbSNP
rs184943355 1454 dbSNP
rs1381996997 1456 dbSNP
rs1420049530 1474 dbSNP
rs982344046 1484 dbSNP
rs1384466337 1493 dbSNP
rs1380617560 1496 dbSNP
rs1336172028 1505 dbSNP
rs1341132776 1511 dbSNP
rs1245960128 1514 dbSNP
rs1313525749 1517 dbSNP
rs138271290 1519 dbSNP
rs1241271779 1529 dbSNP
rs116221964 1534 dbSNP
rs1209504544 1535 dbSNP
rs587648133 1537 dbSNP
rs1256320737 1538 dbSNP
rs1460469425 1547 dbSNP
rs770152443 1549 dbSNP
rs746040791 1566 dbSNP
rs752900739 1569 dbSNP
rs1225694134 1576 dbSNP
rs989166006 1578 dbSNP
rs1158030215 1579 dbSNP
rs1363439105 1585 dbSNP
rs1451978292 1596 dbSNP
rs1174519098 1600 dbSNP
rs1346568378 1602 dbSNP
rs957665597 1610 dbSNP
rs1335348821 1613 dbSNP
rs1379689924 1623 dbSNP
rs1295360445 1627 dbSNP
rs1447995237 1643 dbSNP
rs1381015321 1646 dbSNP
rs1306820698 1652 dbSNP
rs1315492925 1654 dbSNP
rs1235023938 1655 dbSNP
rs587752249 1657 dbSNP
rs1364767438 1671 dbSNP
rs796492050 1673 dbSNP
rs1322252769 1682 dbSNP
rs1290052077 1684 dbSNP
rs1031072027 1685 dbSNP
rs1259928826 1691 dbSNP
rs117968841 1692 dbSNP
rs1019119231 1693 dbSNP
rs1008980332 1694 dbSNP
rs1469369572 1697 dbSNP
rs1174287601 1698 dbSNP
rs879732237 1699 dbSNP
rs1462997858 1700 dbSNP
rs1298085058 1701 dbSNP
rs7517 1703 dbSNP
rs1388845805 1709 dbSNP
rs1283550314 1710 dbSNP
rs1344413019 1711 dbSNP
rs1192288674 1713 dbSNP
rs1221158885 1713 dbSNP
rs1426649667 1715 dbSNP
rs1050608006 1721 dbSNP
rs995035944 1731 dbSNP
rs113682116 1732 dbSNP
rs1249510078 1735 dbSNP
rs150444624 1749 dbSNP
rs1205771154 1751 dbSNP
rs1210158369 1758 dbSNP
rs1269879423 1762 dbSNP
rs1480273605 1770 dbSNP
rs940817923 1772 dbSNP
rs1425933541 1773 dbSNP
rs1429169051 1783 dbSNP
rs587605016 1789 dbSNP
rs1170401257 1805 dbSNP
rs1353215622 1809 dbSNP
rs928006517 1832 dbSNP
rs1046268965 1841 dbSNP
rs1402776661 1844 dbSNP
rs1251090535 1848 dbSNP
rs1279671580 1851 dbSNP
rs1362088780 1852 dbSNP
rs1213433580 1859 dbSNP
rs1225711419 1860 dbSNP
rs1309710266 1876 dbSNP
rs947847309 1881 dbSNP
rs758829365 1886 dbSNP
rs1323365576 1888 dbSNP
rs1296959963 1898 dbSNP
rs916515248 1903 dbSNP
rs188167314 1909 dbSNP
rs371302010 1914 dbSNP
rs1381372262 1916 dbSNP
rs1220591059 1921 dbSNP
rs587706056 1923 dbSNP
rs1265559618 1931 dbSNP
rs748518019 1935 dbSNP
rs1185943643 1950 dbSNP
rs1334170923 1951 dbSNP
rs1417996493 1954 dbSNP
rs1454244222 1967 dbSNP
rs1426144282 1971 dbSNP
rs1164754150 1978 dbSNP
rs1385054333 1986 dbSNP
rs936555910 1997 dbSNP
rs1299686104 2001 dbSNP
rs1345359063 2003 dbSNP
rs1167047156 2011 dbSNP
rs1429422924 2011 dbSNP
rs183764261 2019 dbSNP
rs978154207 2020 dbSNP
rs1453354353 2026 dbSNP
rs1314260052 2031 dbSNP
rs965158805 2034 dbSNP
rs1019758871 2038 dbSNP
rs1286625013 2044 dbSNP
rs1317670304 2060 dbSNP
rs1215322448 2062 dbSNP
rs587604903 2063 dbSNP
rs987611830 2067 dbSNP
rs1240486261 2068 dbSNP
rs1169169710 2069 dbSNP
rs1484264192 2076 dbSNP
rs779192773 2078 dbSNP
rs587723103 2081 dbSNP
rs1184793365 2085 dbSNP
rs192484433 2087 dbSNP
rs1383454290 2096 dbSNP
rs1029097279 2097 dbSNP
rs1160757897 2104 dbSNP
rs1409170111 2106 dbSNP
rs1399813637 2108 dbSNP
rs995088435 2110 dbSNP
rs1360433286 2122 dbSNP
rs1452682172 2129 dbSNP
rs1336028318 2133 dbSNP
rs113372852 2136 dbSNP
rs1380414193 2149 dbSNP
rs1448720084 2150 dbSNP
rs1279987580 2156 dbSNP
rs1372321844 2159 dbSNP
rs899402472 2172 dbSNP
rs1282386555 2179 dbSNP
rs1250083017 2217 dbSNP
rs884 2220 dbSNP
rs757595112 2222 dbSNP
rs886 2224 dbSNP
rs1263069968 2226 dbSNP
rs4970967 2230 dbSNP
rs906638659 2231 dbSNP
rs12023300 2234 dbSNP
rs1469922543 2237 dbSNP
rs1175154303 2249 dbSNP
rs882 2250 dbSNP
rs1426777010 2254 dbSNP
rs116437946 2256 dbSNP
rs948108122 2261 dbSNP
rs1358011531 2266 dbSNP
rs1015 2268 dbSNP
rs587772367 2271 dbSNP
rs1246367403 2284 dbSNP
rs1340638354 2290 dbSNP
rs883 2293 dbSNP
rs1327809240 2295 dbSNP
rs885 2297 dbSNP
rs1389415691 2309 dbSNP
rs1443045077 2313 dbSNP
rs1353748121 2315 dbSNP
rs193172084 2322 dbSNP
rs1439701858 2331 dbSNP
rs1278025133 2337 dbSNP
rs587707017 2347 dbSNP
rs1347554992 2356 dbSNP
rs1398341279 2357 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uacaUCCGGAAAUCUAGUGAa 5'
              |||:   |:||||||| 
Target 5' -ccaAGGUGGGUGGAUCACUu 3'
1 - 20
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000369014.5 | 3UTR | CCAAGGUGGGUGGAUCACUUGAGGUCAGGAGUUUGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
UCEC 0.575 0.31 0.500 0.33 3 Click to see details
HNSC 0.22 0.32 0.464 0.15 7 Click to see details
BLCA -0.501 0.33 -0.500 0.33 3 Click to see details
BRCA 0.304 0.4 -0.500 0.33 3 Click to see details
BRCA 0.304 0.4 -0.500 0.33 3 Click to see details
BRCA 0.304 0.4 -0.500 0.33 3 Click to see details
BRCA 0.304 0.4 -0.500 0.33 3 Click to see details
BRCA 0.304 0.4 -0.500 0.33 3 Click to see details
109 hsa-miR-1245a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006574 BRCA2 BRCA2, DNA repair associated 2 1
MIRT055432 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT063879 RASSF8 Ras association domain family member 8 2 6
MIRT077025 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT095775 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT099172 MAP3K4 mitogen-activated protein kinase kinase kinase 4 2 2
MIRT175616 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT456518 LYPLAL1 lysophospholipase like 1 2 2
MIRT464457 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465747 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT468257 SFXN4 sideroflexin 4 2 2
MIRT469216 RICTOR RPTOR independent companion of MTOR complex 2 2 2
MIRT472045 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT481795 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT500154 CREBBP CREB binding protein 2 2
MIRT506514 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 4
MIRT506915 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT513901 GRB10 growth factor receptor bound protein 10 2 6
MIRT519128 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT528121 FOXH1 forkhead box H1 2 2
MIRT528942 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT540580 CEP89 centrosomal protein 89 2 2
MIRT545858 ZNF264 zinc finger protein 264 2 4
MIRT547147 PGM3 phosphoglucomutase 3 2 2
MIRT547434 MED4 mediator complex subunit 4 2 2
MIRT554650 ROBO1 roundabout guidance receptor 1 2 2
MIRT558524 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT559762 ABHD5 abhydrolase domain containing 5 2 2
MIRT560438 GOLGA7B golgin A7 family member B 2 2
MIRT561974 LRRC59 leucine rich repeat containing 59 2 2
MIRT562442 DDIT4 DNA damage inducible transcript 4 2 2
MIRT563489 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT568265 BMP2K BMP2 inducible kinase 2 2
MIRT572522 KIAA0232 KIAA0232 2 2
MIRT612801 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT621533 ZNF507 zinc finger protein 507 2 2
MIRT625205 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT625615 ZNF84 zinc finger protein 84 2 2
MIRT629215 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629509 AS3MT arsenite methyltransferase 2 2
MIRT629769 STK25 serine/threonine kinase 25 2 2
MIRT630908 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT632508 RAB13 RAB13, member RAS oncogene family 2 2
MIRT636871 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT637106 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637332 FAM9B family with sequence similarity 9 member B 2 2
MIRT637553 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637639 ZNF431 zinc finger protein 431 2 2
MIRT637836 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT638326 RNF11 ring finger protein 11 2 2
MIRT638393 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT642450 CLUAP1 clusterin associated protein 1 2 2
MIRT642616 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT643133 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644324 NFKBID NFKB inhibitor delta 2 2
MIRT645150 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT645673 ADK adenosine kinase 2 2
MIRT646091 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646858 SLC35E4 solute carrier family 35 member E4 2 2
MIRT650153 ZNF426 zinc finger protein 426 2 2
MIRT652483 TMEM181 transmembrane protein 181 2 2
MIRT653790 SIRPA signal regulatory protein alpha 2 2
MIRT655526 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT657077 JPH2 junctophilin 2 2 2
MIRT657322 HOOK3 hook microtubule tethering protein 3 2 2
MIRT662036 FUT2 fucosyltransferase 2 2 2
MIRT662322 ADM2 adrenomedullin 2 2 2
MIRT663211 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663559 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663937 ZNF554 zinc finger protein 554 2 2
MIRT664689 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT664709 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT665291 ZFP14 ZFP14 zinc finger protein 2 2
MIRT665572 TXNL1 thioredoxin like 1 2 2
MIRT667068 PAOX polyamine oxidase 2 2
MIRT667304 MYO5A myosin VA 2 2
MIRT667442 METTL14 methyltransferase like 14 2 2
MIRT668048 GTPBP10 GTP binding protein 10 2 2
MIRT669604 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT671088 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT674361 SLC35E3 solute carrier family 35 member E3 2 2
MIRT674962 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT676394 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676819 AGMAT agmatinase 2 2
MIRT676891 ENSA endosulfine alpha 2 2
MIRT677059 ZNF34 zinc finger protein 34 2 2
MIRT678424 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678735 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT678930 XPOT exportin for tRNA 2 2
MIRT678954 MYADM myeloid associated differentiation marker 2 2
MIRT679228 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679765 TLR6 toll like receptor 6 2 2
MIRT681992 HRH4 histamine receptor H4 2 2
MIRT687405 NSUN4 NOP2/Sun RNA methyltransferase family member 4 2 2
MIRT694570 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT698449 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT706406 HAS2 hyaluronan synthase 2 2 2
MIRT706582 ZNF432 zinc finger protein 432 2 2
MIRT706838 VHLL VHL like 2 2
MIRT706909 DVL3 dishevelled segment polarity protein 3 2 2
MIRT707052 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT708583 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT708988 CABP4 calcium binding protein 4 2 2
MIRT713041 ADRA2B adrenoceptor alpha 2B 2 2
MIRT713731 SUCO SUN domain containing ossification factor 2 2
MIRT714968 RAB21 RAB21, member RAS oncogene family 2 2
MIRT717485 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT722826 KLK2 kallikrein related peptidase 2 2 2
MIRT723305 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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