pre-miRNA Information
pre-miRNA hsa-mir-640   
Genomic Coordinates chr19: 19435063 - 19435158
Synonyms MIRN640, hsa-mir-640, MIR640
Description Homo sapiens miR-640 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-640
Sequence 61| AUGAUCCAGGAACCUGCCUCU |81
Evidence Experimental
Experiments RT-PCR
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30153378 1 COSMIC
COSN23015356 12 COSMIC
COSN30513185 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs111726405 1 dbSNP
rs765622881 2 dbSNP
rs1249744889 6 dbSNP
rs752995186 12 dbSNP
rs758746736 13 dbSNP
rs918887970 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PDLIM3   
Synonyms ALP
Description PDZ and LIM domain 3
Transcript NM_001114107   
Other Transcripts NM_014476   
Expression
Putative miRNA Targets on PDLIM3
3'UTR of PDLIM3
(miRNA target sites are highlighted)
>PDLIM3|NM_001114107|3'UTR
   1 GTCTCTGCAGGCGTGGCACGCACGCACGCACCCACCCACGCGCACTTACACGAGAAGACATTCATGGCTTTGGGCAGAAG
  81 GATTGTGCAGATTGTCAACTCCAAATCTAAAGTCAAGGCTTTAGACCTTTATCCTATTGTTTATTGAGGAAAAGGAATGG
 161 GAGGCAAATGCCTGCTATGTGAAAAAAACATACACTTAGCTATGTTTTGCAACTCTTTTTGGGGCTAGCAATAATGATAT
 241 TTAAAGCAATAATTTTTTGTATGTCATACTCCACAATTTACATGTATATTACAGCCATCAAACACATAAACATCAAGATA
 321 TTTGAAGGACTCTAATTGTCTTTCCTTGACAAGTTGATTTTGCAATTGTGGTAAATAGCAAATAACAATCTTGTATTCTA
 401 ACATAATCTGCAGTTGTCTGTATGTGTTTTAACTATTACAGTGCATGTTAGGGAGAAATTCCCTGAATTTCTTTAGTTTT
 481 GTATTCAAACAATTATGCCACTCGATGCAACAAACATAATAAATACATAAAAGATTTAAAAAATACCTAATGAAGTGGCA
 561 TTCATTGAATTCAAATAAAATCAACATTTCAATGAGAGAACCCAATCATATTTTAACATGTACACTAACAAATATTTTAA
 641 GATAAATGTGGCTTCTTCAGGTTTTATAACTCATTACTCTTTCTTATGAGCACAAAATTTCTGATGATAGAAGCGTTGAA
 721 ATTTGCTAGTTAAAGGTAGTTCAGTCTCTTTCAAATTAAAAGTTTCACTTGCTTCAACAGAGACTCTTTCAATTTAAATA
 801 TCTCTTTCAGATCAATATTCAGTCAAATTGAAGGTTCAAAGTCCATCACTGCTGTTTCTTAGGCTCAATGGTTCACCACC
 881 TCCTCCTCTTCCCAAGATGGCATCTCCAGGAAGAAACAATTTAGACGACTTCCTAAGGAAGGCAGGGGCTGCTGGTCTCC
 961 TGGGGTCCTGCTTGTATCCACTGTTGAAATCCTTGGTTTCACTTGTGATCTGTGGTCTGTTTTCTTGACATAGTTGAGGC
1041 CAGGCAATAATAACACCTCCACTACCACCTCCAAAACTCTCAGCTCAGCTTTCCTGGAGTCATGGATCCTCTGTCTGAGA
1121 CATGCACTCTGCCTGGCCCTGGCGCAGGCAGCCTACCTTGCAGGCTCTGCATGGCGTTACCTTGCCTCTCACCCAGGGTG
1201 CCCATGGCAATGCTCCTGACTTGCATCTCTCACCTACTTTCCATGTCCCCCACTGGGGACGTACAGGAACTTCTGAAACT
1281 GTCCCCTCAGGTTCAAACCATGGGGAACCAGCAGGGTGGGGACCCTCAGACCCTCTGTCTCACCACCTTGTGTCACATGG
1361 TCATCTCTACCACCCCTCAACCCCCACAGCTGCTAACTTCTGGCCTGAAACAAGTGTTCTCCTCCCATAAGGTCCCAAAT
1441 GGGACACAAGTTTTATTGCTCTGGGATTCTTCCAAACTTAACTGACTCTGACCCTGACCTGTTCAGGATTTTGAGAGGAG
1521 CCAAAACACGTGCCTGGCCCCTGTAGGCATTTGACATTGCAACTCCTGTGCCAACACATGCATTCACTAACAAAGCTATT
1601 AAAAAAATAAAACAGACTTTTGAGATCAAAGAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucuccGUC-CAAGGACCU-AGUa 5'
               |||  |||||||| ||| 
Target 5' cagctCAGCTTTCCTGGAGTCAt 3'
1081 - 1103 132.00 -17.10
2
miRNA  3' ucuccGUCCAAGGAC-CUAGUa 5'
               |||  |::|| ||||| 
Target 5' taaaaCAGACTTTTGAGATCAa 3'
1608 - 1629 124.00 -11.00
3
miRNA  3' ucuccGUCCAAG-GACCUAGUa 5'
               :||| ||  ||| ||| 
Target 5' tttctTAGGCTCAATGGTTCAc 3'
855 - 876 120.00 -9.37
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
138676 12 ClinVar
COSN30158973 3 COSMIC
COSN20161286 5 COSMIC
COSN30157870 13 COSMIC
COSN30629138 16 COSMIC
COSN30150524 18 COSMIC
COSN30523807 19 COSMIC
COSN30648558 20 COSMIC
COSN30535173 23 COSMIC
COSN30144232 24 COSMIC
COSN15663747 27 COSMIC
COSN18729345 28 COSMIC
COSN31580386 28 COSMIC
COSN30455773 33 COSMIC
COSN31613390 36 COSMIC
COSN30180596 39 COSMIC
COSN31503216 39 COSMIC
COSN30139623 40 COSMIC
COSN30496752 41 COSMIC
COSN30129555 42 COSMIC
COSN26988518 52 COSMIC
COSN31601793 54 COSMIC
COSN26434333 94 COSMIC
COSN31598440 140 COSMIC
COSN30140781 156 COSMIC
COSN31594374 170 COSMIC
COSN28844677 182 COSMIC
COSN24300557 188 COSMIC
COSN31576999 444 COSMIC
COSN9893336 747 COSMIC
COSN29576787 974 COSMIC
COSN9021350 1190 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1253543718 3 dbSNP
rs375486713 6 dbSNP
rs1436658897 11 dbSNP
rs8315 12 dbSNP
rs778200293 13 dbSNP
rs1212832231 15 dbSNP
rs368044283 19 dbSNP
rs780025014 20 dbSNP
rs960579235 23 dbSNP
rs758218049 24 dbSNP
rs1286718711 25 dbSNP
rs750420548 26 dbSNP
rs376717121 27 dbSNP
rs761449278 28 dbSNP
rs1002162292 31 dbSNP
rs761264018 32 dbSNP
rs768400964 32 dbSNP
rs780921610 32 dbSNP
rs371829497 37 dbSNP
rs763532013 39 dbSNP
rs746822252 40 dbSNP
rs760353439 40 dbSNP
rs942451918 41 dbSNP
rs372485189 42 dbSNP
rs779953596 42 dbSNP
rs772476014 43 dbSNP
rs759790199 45 dbSNP
rs1159957437 47 dbSNP
rs370106550 51 dbSNP
rs755536797 52 dbSNP
rs148691818 67 dbSNP
rs986715552 73 dbSNP
rs368849057 75 dbSNP
rs952304578 77 dbSNP
rs1372310903 81 dbSNP
rs534506122 83 dbSNP
rs1801942 89 dbSNP
rs543966966 92 dbSNP
rs754994101 94 dbSNP
rs1209201601 112 dbSNP
rs138685478 126 dbSNP
rs762007178 127 dbSNP
rs555855515 131 dbSNP
rs962010604 133 dbSNP
rs1452535072 135 dbSNP
rs187351154 144 dbSNP
rs1014274071 146 dbSNP
rs1186850413 162 dbSNP
rs1449080693 162 dbSNP
rs1387503818 184 dbSNP
rs1458686211 187 dbSNP
rs199939796 189 dbSNP
rs773329945 190 dbSNP
rs1389160272 191 dbSNP
rs1402006846 193 dbSNP
rs558188684 203 dbSNP
rs1034164382 204 dbSNP
rs1432449526 219 dbSNP
rs1191561154 220 dbSNP
rs1000439760 221 dbSNP
rs904406189 224 dbSNP
rs889326837 231 dbSNP
rs1282400076 233 dbSNP
rs1352749591 235 dbSNP
rs1050634174 243 dbSNP
rs1264194574 252 dbSNP
rs548957631 259 dbSNP
rs767555533 261 dbSNP
rs1258500691 262 dbSNP
rs930929159 269 dbSNP
rs899312410 270 dbSNP
rs1485624842 273 dbSNP
rs541706931 277 dbSNP
rs182665079 285 dbSNP
rs13808 296 dbSNP
rs1367293834 300 dbSNP
rs939736973 310 dbSNP
rs1473865064 314 dbSNP
rs1212271246 315 dbSNP
rs75416326 319 dbSNP
rs535651539 323 dbSNP
rs1232640555 324 dbSNP
rs889550834 325 dbSNP
rs1395312843 338 dbSNP
rs1050575057 350 dbSNP
rs991786599 352 dbSNP
rs1331940097 355 dbSNP
rs191350771 365 dbSNP
rs1337252823 375 dbSNP
rs1228937408 388 dbSNP
rs938999254 389 dbSNP
rs1367813023 392 dbSNP
rs1296654063 410 dbSNP
rs1328637528 411 dbSNP
rs1381333273 421 dbSNP
rs555832116 422 dbSNP
rs1359374267 426 dbSNP
rs1258050917 432 dbSNP
rs1483693462 433 dbSNP
rs1200027715 434 dbSNP
rs1254513854 436 dbSNP
rs1183568395 444 dbSNP
rs1484217388 444 dbSNP
rs1411847120 446 dbSNP
rs1471347568 450 dbSNP
rs930812255 455 dbSNP
rs78718131 464 dbSNP
rs570065636 466 dbSNP
rs1170378089 474 dbSNP
rs980673114 482 dbSNP
rs1374848983 495 dbSNP
rs940969499 499 dbSNP
rs917234064 504 dbSNP
rs967979577 506 dbSNP
rs546996970 519 dbSNP
rs1171664995 523 dbSNP
rs988002722 528 dbSNP
rs1312777950 529 dbSNP
rs1232845869 531 dbSNP
rs956969925 533 dbSNP
rs1431485848 544 dbSNP
rs529196226 545 dbSNP
rs1373431003 559 dbSNP
rs1019031754 567 dbSNP
rs1251813872 569 dbSNP
rs958780616 582 dbSNP
rs1034856578 588 dbSNP
rs978903594 592 dbSNP
rs1432053791 594 dbSNP
rs762162001 595 dbSNP
rs1259887443 601 dbSNP
rs1430240131 602 dbSNP
rs1020156271 606 dbSNP
rs1190198546 607 dbSNP
rs1486036682 613 dbSNP
rs186064417 619 dbSNP
rs1209361911 621 dbSNP
rs1293999665 623 dbSNP
rs568285552 629 dbSNP
rs375193739 630 dbSNP
rs899428297 639 dbSNP
rs1367615916 640 dbSNP
rs1305451762 646 dbSNP
rs1314428635 651 dbSNP
rs1274391621 652 dbSNP
rs1340400674 660 dbSNP
rs1036904504 661 dbSNP
rs931116451 666 dbSNP
rs1414932186 671 dbSNP
rs899319642 679 dbSNP
rs1449712093 684 dbSNP
rs531387220 685 dbSNP
rs1310464673 686 dbSNP
rs1411616393 687 dbSNP
rs940871931 688 dbSNP
rs1036516852 709 dbSNP
rs141244540 711 dbSNP
rs372697634 711 dbSNP
rs200046367 712 dbSNP
rs896014713 714 dbSNP
rs774422758 715 dbSNP
rs1457529030 725 dbSNP
rs1371622987 733 dbSNP
rs1167354080 736 dbSNP
rs1390859493 743 dbSNP
rs142605384 745 dbSNP
rs1297093877 755 dbSNP
rs1360344342 759 dbSNP
rs1256939895 772 dbSNP
rs937331659 777 dbSNP
rs1185836571 784 dbSNP
rs1440108509 788 dbSNP
rs543892230 790 dbSNP
rs1321624535 801 dbSNP
rs1219929665 802 dbSNP
rs1269483810 815 dbSNP
rs1464923467 818 dbSNP
rs533183877 822 dbSNP
rs980449297 828 dbSNP
rs946594238 838 dbSNP
rs1484136001 839 dbSNP
rs1182231768 843 dbSNP
rs1413054004 848 dbSNP
rs1422001461 851 dbSNP
rs1161204475 862 dbSNP
rs968861350 868 dbSNP
rs1020102516 870 dbSNP
rs182935943 874 dbSNP
rs988660462 879 dbSNP
rs1450699853 889 dbSNP
rs1303803069 900 dbSNP
rs139597307 904 dbSNP
rs1479857495 918 dbSNP
rs988341060 921 dbSNP
rs1329298962 923 dbSNP
rs146342573 926 dbSNP
rs889446269 927 dbSNP
rs1313576486 929 dbSNP
rs1210313346 931 dbSNP
rs911759897 941 dbSNP
rs987502991 945 dbSNP
rs953483646 949 dbSNP
rs995651588 955 dbSNP
rs1252423928 957 dbSNP
rs896922310 963 dbSNP
rs190641322 964 dbSNP
rs1405803594 965 dbSNP
rs1416382616 966 dbSNP
rs1036449887 967 dbSNP
rs1358970876 968 dbSNP
rs1413297271 974 dbSNP
rs1028922284 991 dbSNP
rs1310427483 999 dbSNP
rs1240534785 1003 dbSNP
rs994806158 1011 dbSNP
rs1336316710 1015 dbSNP
rs1408754788 1016 dbSNP
rs757273445 1019 dbSNP
rs1015176458 1030 dbSNP
rs1005014669 1037 dbSNP
rs1346425675 1038 dbSNP
rs1005582271 1039 dbSNP
rs555770042 1047 dbSNP
rs1219483518 1048 dbSNP
rs1328095713 1054 dbSNP
rs1277423848 1055 dbSNP
rs1345531893 1057 dbSNP
rs896023587 1066 dbSNP
rs1275332989 1074 dbSNP
rs542551699 1087 dbSNP
rs1482693146 1093 dbSNP
rs1179838006 1099 dbSNP
rs187425356 1101 dbSNP
rs1231283429 1107 dbSNP
rs895974296 1107 dbSNP
rs867872290 1112 dbSNP
rs1389518080 1117 dbSNP
rs1392623682 1127 dbSNP
rs1326289484 1128 dbSNP
rs1433323380 1131 dbSNP
rs1057345635 1134 dbSNP
rs1170865425 1137 dbSNP
rs1003269942 1139 dbSNP
rs1417391725 1142 dbSNP
rs377496000 1143 dbSNP
rs1471198864 1144 dbSNP
rs1364942772 1149 dbSNP
rs1332344043 1150 dbSNP
rs1043078348 1156 dbSNP
rs947431653 1164 dbSNP
rs1368315095 1165 dbSNP
rs1230080262 1173 dbSNP
rs913320593 1174 dbSNP
rs1044716468 1175 dbSNP
rs775312727 1176 dbSNP
rs539104778 1181 dbSNP
rs1453439374 1183 dbSNP
rs1222394101 1186 dbSNP
rs1252673260 1186 dbSNP
rs1452824907 1188 dbSNP
rs1190684338 1195 dbSNP
rs946403601 1197 dbSNP
rs1449195412 1203 dbSNP
rs1166716373 1204 dbSNP
rs1393479881 1213 dbSNP
rs914929921 1215 dbSNP
rs1405500880 1217 dbSNP
rs1322318768 1227 dbSNP
rs1287607287 1228 dbSNP
rs1391559883 1232 dbSNP
rs1436866459 1233 dbSNP
rs988608173 1240 dbSNP
rs142055691 1246 dbSNP
rs75435241 1249 dbSNP
rs1214649856 1254 dbSNP
rs1285952253 1259 dbSNP
rs911706215 1260 dbSNP
rs533529576 1261 dbSNP
rs953430827 1266 dbSNP
rs1206444369 1280 dbSNP
rs1467162739 1282 dbSNP
rs1350750051 1291 dbSNP
rs1278384908 1304 dbSNP
rs1210849726 1305 dbSNP
rs1236830968 1308 dbSNP
rs1373030648 1316 dbSNP
rs1303943368 1326 dbSNP
rs764223014 1332 dbSNP
rs1027036818 1341 dbSNP
rs1163142497 1343 dbSNP
rs1415048886 1344 dbSNP
rs1189571742 1347 dbSNP
rs1320855596 1352 dbSNP
rs973936414 1369 dbSNP
rs1339767928 1376 dbSNP
rs1335952442 1384 dbSNP
rs963405160 1387 dbSNP
rs1340778188 1389 dbSNP
rs1015370075 1397 dbSNP
rs1402612211 1403 dbSNP
rs1332835522 1404 dbSNP
rs1385764804 1406 dbSNP
rs961078121 1407 dbSNP
rs568078360 1423 dbSNP
rs1469070768 1424 dbSNP
rs1005118423 1425 dbSNP
rs1015290638 1432 dbSNP
rs1443302411 1433 dbSNP
rs1397400368 1435 dbSNP
rs960295852 1445 dbSNP
rs1194695859 1447 dbSNP
rs895971591 1450 dbSNP
rs1269858885 1455 dbSNP
rs1473324996 1456 dbSNP
rs1035830574 1458 dbSNP
rs1159241604 1464 dbSNP
rs548176737 1466 dbSNP
rs538184191 1475 dbSNP
rs1001709002 1477 dbSNP
rs904902223 1486 dbSNP
rs1002166762 1493 dbSNP
rs906135831 1501 dbSNP
rs541555734 1513 dbSNP
rs1311038619 1516 dbSNP
rs1011106863 1517 dbSNP
rs893458227 1521 dbSNP
rs1411812774 1524 dbSNP
rs1052554104 1529 dbSNP
rs935235606 1530 dbSNP
rs913268438 1536 dbSNP
rs1257955300 1537 dbSNP
rs76273488 1540 dbSNP
rs1210607734 1541 dbSNP
rs1051508696 1543 dbSNP
rs1282971097 1548 dbSNP
rs1202834786 1556 dbSNP
rs1484329932 1564 dbSNP
rs1350014834 1565 dbSNP
rs1183450642 1575 dbSNP
rs944126370 1577 dbSNP
rs1416742460 1587 dbSNP
rs931813877 1595 dbSNP
rs1377816494 1597 dbSNP
rs912370581 1601 dbSNP
rs552418262 1609 dbSNP
rs1372119444 1620 dbSNP
rs533440141 1625 dbSNP
rs1430362938 1627 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ucuccguccaaggACCUAGUa 5'
                       ||||||| 
Target 5' ---------ugggUGGAUCAu 3'
1 - 12
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000284770.5 | 3UTR | UGGGUGGAUCAUGAGGUCAGGAGUUCAAGACCAGCCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.546 2.9e-3 -0.477 9.2e-3 24 Click to see details
GSE21687 Ependynoma primary tumors -0.33 3.9e-3 -0.401 5.1e-4 64 Click to see details
GSE28260 Renal cortex and medulla -0.685 4.9e-3 -0.592 1.7e-2 13 Click to see details
GSE21849 B cell lymphoma -0.413 1.3e-2 -0.492 3.4e-3 29 Click to see details
GSE27834 Pluripotent stem cells 0.395 6.5e-2 0.324 1.1e-1 16 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.249 1.2e-1 0.280 8.8e-2 25 Click to see details
GSE17306 Multiple myeloma -0.166 1.3e-1 -0.079 2.9e-1 49 Click to see details
GSE19783 ER+ ER+ breast cancer -0.19 2.1e-1 0.008 4.9e-1 20 Click to see details
GSE42095 Differentiated embryonic stem cells -0.157 2.4e-1 0.000 5.0e-1 23 Click to see details
GSE19536 Breast cancer -0.072 2.4e-1 -0.042 3.4e-1 100 Click to see details
GSE14794 Lymphoblastoid cells 0.066 2.7e-1 0.059 2.9e-1 90 Click to see details
GSE32688 Pancreatic cancer -0.094 3.0e-1 -0.041 4.1e-1 32 Click to see details
GSE17498 Multiple myeloma -0.076 3.2e-1 -0.117 2.4e-1 40 Click to see details
GSE38226 Liver fibrosis 0.098 3.4e-1 0.117 3.1e-1 21 Click to see details
GSE19350 CNS germ cell tumors -0.061 4.3e-1 0.427 8.3e-2 12 Click to see details
GSE19783 ER- ER- breast cancer -0.021 4.3e-1 -0.013 4.5e-1 79 Click to see details
GSE26953 Aortic valvular endothelial cells 0.039 4.3e-1 0.020 4.6e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.013 4.8e-1 -0.131 2.9e-1 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.01 4.8e-1 -0.021 4.6e-1 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.01 4.8e-1 -0.021 4.6e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
194 hsa-miR-640 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT097121 TNPO1 transportin 1 2 2
MIRT115090 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 4
MIRT204603 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204634 MOB4 MOB family member 4, phocein 2 8
MIRT344451 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT405772 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT445876 SENP6 SUMO1/sentrin specific peptidase 6 2 2
MIRT497418 FAM46A family with sequence similarity 46 member A 2 2
MIRT504394 HMX2 H6 family homeobox 2 2 4
MIRT504691 SLCO2B1 solute carrier organic anion transporter family member 2B1 2 8
MIRT512386 MTRNR2L3 MT-RNR2-like 3 2 6
MIRT513003 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT513084 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT519122 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT523836 F2RL1 F2R like trypsin receptor 1 2 2
MIRT565356 TMCC1 transmembrane and coiled-coil domain family 1 2 2
MIRT575895 Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT576894 Poteg POTE ankyrin domain family, member G 2 2
MIRT613780 RPS6 ribosomal protein S6 2 2
MIRT613934 POLR3A RNA polymerase III subunit A 2 2
MIRT614348 LOH12CR1 BLOC-1 related complex subunit 5 2 2
MIRT614534 NOA1 nitric oxide associated 1 2 2
MIRT617019 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT618247 MANEAL mannosidase endo-alpha like 2 2
MIRT619051 TTC4 tetratricopeptide repeat domain 4 2 2
MIRT619442 ZNF517 zinc finger protein 517 2 2
MIRT619723 FPR2 formyl peptide receptor 2 2 2
MIRT620179 TRIM72 tripartite motif containing 72 2 2
MIRT620370 ANKRD62 ankyrin repeat domain 62 2 2
MIRT621263 RTN2 reticulon 2 2 2
MIRT621463 APOH apolipoprotein H 2 2
MIRT621571 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT621683 TSPYL1 TSPY like 1 2 2
MIRT622866 PDE7A phosphodiesterase 7A 2 2
MIRT624669 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT625607 ZNF84 zinc finger protein 84 2 2
MIRT626111 IL23R interleukin 23 receptor 2 2
MIRT628380 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT628553 MELK maternal embryonic leucine zipper kinase 2 2
MIRT628671 C2orf72 chromosome 2 open reading frame 72 2 2
MIRT628747 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT628776 TMEM154 transmembrane protein 154 2 2
MIRT628918 ZNF430 zinc finger protein 430 2 2
MIRT629174 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT629209 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629267 SLC5A8 solute carrier family 5 member 8 2 2
MIRT629498 AS3MT arsenite methyltransferase 2 2
MIRT629665 USP1 ubiquitin specific peptidase 1 2 2
MIRT629760 STK25 serine/threonine kinase 25 2 2
MIRT630899 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT631105 SLC15A2 solute carrier family 15 member 2 2 2
MIRT631112 ATCAY ATCAY, caytaxin 2 2
MIRT631450 DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 2 2
MIRT631505 FFAR4 free fatty acid receptor 4 2 2
MIRT631580 ITGAL integrin subunit alpha L 2 2
MIRT631836 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT632342 SWSAP1 SWIM-type zinc finger 7 associated protein 1 2 2
MIRT633214 ZNF584 zinc finger protein 584 2 2
MIRT633223 ZNF43 zinc finger protein 43 2 2
MIRT633480 ARIH2OS ariadne RBR E3 ubiquitin protein ligase 2 opposite strand 2 2
MIRT633511 LRRC27 leucine rich repeat containing 27 2 2
MIRT633615 CWF19L1 CWF19 like 1, cell cycle control (S. pombe) 2 2
MIRT633652 SLC28A1 solute carrier family 28 member 1 2 2
MIRT633677 ZNF576 zinc finger protein 576 2 2
MIRT634196 TMOD2 tropomodulin 2 2 4
MIRT634388 PLSCR1 phospholipid scramblase 1 2 2
MIRT635817 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT635962 TTC31 tetratricopeptide repeat domain 31 2 2
MIRT636114 YPEL1 yippee like 1 2 2
MIRT636164 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636768 CLUAP1 clusterin associated protein 1 2 2
MIRT637092 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637316 FAM9B family with sequence similarity 9 member B 2 2
MIRT637540 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637628 ZNF431 zinc finger protein 431 2 2
MIRT637826 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT637945 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT637968 IRF1 interferon regulatory factor 1 2 2
MIRT638321 RNF11 ring finger protein 11 2 2
MIRT638386 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT639244 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT642608 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT642793 SLC1A5 solute carrier family 1 member 5 2 2
MIRT643847 LACTB lactamase beta 2 4
MIRT644705 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT645148 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT646671 CCDC69 coiled-coil domain containing 69 2 2
MIRT647780 ASB8 ankyrin repeat and SOCS box containing 8 2 2
MIRT648554 WDR92 WD repeat domain 92 2 2
MIRT648990 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT649099 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT650141 ZNF426 zinc finger protein 426 2 2
MIRT650791 GSR glutathione-disulfide reductase 2 2
MIRT654967 PLEKHA2 pleckstrin homology domain containing A2 2 2
MIRT655099 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT655516 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT656289 METTL14 methyltransferase like 14 2 2
MIRT656497 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657074 JPH2 junctophilin 2 2 2
MIRT657314 HOOK3 hook microtubule tethering protein 3 2 2
MIRT657419 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT659032 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659535 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT661532 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT662029 FUT2 fucosyltransferase 2 2 2
MIRT663206 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663357 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT663557 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663650 POLM DNA polymerase mu 2 2
MIRT663694 ABHD17B abhydrolase domain containing 17B 2 2
MIRT664370 CYB5A cytochrome b5 type A 2 2
MIRT664783 LIAS lipoic acid synthetase 2 4
MIRT665561 TXNL1 thioredoxin like 1 2 2
MIRT665950 TAOK1 TAO kinase 1 2 2
MIRT667338 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT667804 ITIH5 inter-alpha-trypsin inhibitor heavy chain family member 5 2 2
MIRT668804 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT669470 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT669599 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT669806 STOML1 stomatin like 1 2 2
MIRT669944 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT670292 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670381 EMP2 epithelial membrane protein 2 2 2
MIRT670481 DCUN1D2 defective in cullin neddylation 1 domain containing 2 2 2
MIRT670531 KIF1C kinesin family member 1C 2 4
MIRT670565 GLTP glycolipid transfer protein 2 2
MIRT670603 NPHP1 nephrocystin 1 2 2
MIRT670880 CYTIP cytohesin 1 interacting protein 2 2
MIRT670931 LIPG lipase G, endothelial type 2 2
MIRT671261 MTRNR2L5 MT-RNR2-like 5 2 2
MIRT671794 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT671897 GBP4 guanylate binding protein 4 2 2
MIRT672000 SLC35F6 solute carrier family 35 member F6 2 4
MIRT672074 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT672319 C9orf3 chromosome 9 open reading frame 3 2 2
MIRT672853 C22orf29 retrotransposon Gag like 10 2 2
MIRT673395 WNT7B Wnt family member 7B 2 2
MIRT673537 DEGS1 delta 4-desaturase, sphingolipid 1 2 2
MIRT674285 ZNF724P zinc finger protein 724 2 2
MIRT674494 TIRAP TIR domain containing adaptor protein 2 2
MIRT675460 NUBPL nucleotide binding protein like 2 2
MIRT675569 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT676068 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676254 PBOV1 prostate and breast cancer overexpressed 1 2 2
MIRT676377 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676758 SNX2 sorting nexin 2 2 2
MIRT676773 NPHS1 NPHS1, nephrin 2 2
MIRT676874 ENSA endosulfine alpha 2 2
MIRT676918 KLHDC8A kelch domain containing 8A 2 2
MIRT676944 S1PR3 sphingosine-1-phosphate receptor 3 2 2
MIRT676957 HFE hemochromatosis 2 2
MIRT676967 RNF19B ring finger protein 19B 2 2
MIRT676972 ZNF708 zinc finger protein 708 2 2
MIRT677042 ZNF34 zinc finger protein 34 2 2
MIRT677070 VMAC vimentin type intermediate filament associated coiled-coil protein 2 2
MIRT677093 MFSD11 major facilitator superfamily domain containing 11 2 4
MIRT677134 P2RX7 purinergic receptor P2X 7 2 2
MIRT677179 ZNF786 zinc finger protein 786 2 2
MIRT677228 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677320 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT677455 PDLIM3 PDZ and LIM domain 3 2 2
MIRT677809 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT677937 ZNF519 zinc finger protein 519 2 2
MIRT678063 UBN2 ubinuclein 2 2 4
MIRT678072 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678252 FXN frataxin 2 2
MIRT678315 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678367 XIAP X-linked inhibitor of apoptosis 2 4
MIRT678372 RNF115 ring finger protein 115 2 2
MIRT678410 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678518 ZNF347 zinc finger protein 347 2 2
MIRT678566 CDK4 cyclin dependent kinase 4 2 2
MIRT678580 PPP1R3B protein phosphatase 1 regulatory subunit 3B 2 2
MIRT678820 PDE6A phosphodiesterase 6A 2 2
MIRT678917 XPOT exportin for tRNA 2 2
MIRT679217 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679437 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT679595 HILPDA hypoxia inducible lipid droplet associated 2 2
MIRT679755 TLR6 toll like receptor 6 2 2
MIRT679800 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 2 2
MIRT680057 CD96 CD96 molecule 2 2
MIRT680116 CCDC30 coiled-coil domain containing 30 2 4
MIRT680181 ZNF554 zinc finger protein 554 2 2
MIRT680439 WDR12 WD repeat domain 12 2 2
MIRT680789 ZNF578 zinc finger protein 578 2 2
MIRT692464 APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2 2 2
MIRT702952 HIP1 huntingtin interacting protein 1 2 2
MIRT706016 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT706032 F2R coagulation factor II thrombin receptor 2 2
MIRT706135 MTRNR2L10 MT-RNR2-like 10 2 2
MIRT706394 HAS2 hyaluronan synthase 2 2 2
MIRT713293 DCP2 decapping mRNA 2 2 2
MIRT716583 BRAP BRCA1 associated protein 2 2
MIRT720433 C19orf47 chromosome 19 open reading frame 47 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-640 Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer tissue and cell line (SKOV3)
hsa-miR-640 Cetuximab resistant High Colon Cancer cell line
hsa-miR-640 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Mitoxantrone 4212 NSC279836 approved resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-640 Sorafenib 216239 NSC747971 approved sensitive Low Clear Cell Renal Cell Carcinoma cell line (786-O)
hsa-mir-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-640 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-640 Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-640 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

Error report submission