pre-miRNA Information
pre-miRNA hsa-mir-4301   
Genomic Coordinates chr11: 113450023 - 113450088
Description Homo sapiens miR-4301 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4301
Sequence 11| UCCCACUACUUCACUUGUGA |30
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs184176277 2 dbSNP
rs1191324913 13 dbSNP
rs1369198005 15 dbSNP
rs1036973189 16 dbSNP
rs944900541 18 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ELOF1   
Synonyms ELF1
Description elongation factor 1 homolog
Transcript NM_032377   
Expression
Putative miRNA Targets on ELOF1
3'UTR of ELOF1
(miRNA target sites are highlighted)
>ELOF1|NM_032377|3'UTR
   1 CGACACAGAGGACCCGCCCCCTGAGCAGCCCCGCGTACTGTGGATCCAGCTGTTCGGTTCTGGTCCAGAGACATTCCAGG
  81 GGTCCAGGGTGTGGGTCCTGGGCTGTCACAGCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG
 161 TGTAGTGGGTGTGCGTGTGGGTGTGGGTGTGAGTGAGTGTGGGTGTGTGTGGCTGCACGTGTCACTGGGGTGGCCGTGAG
 241 TGTGTGCTCACAGGTACGCGGTGGTGTCGGGTTCCTGGGCCTGAGGGGCCTGAACTGATCTCACTTGGCTCCGAAAGCCT
 321 TTGCTGTGTTCCCTGCAGCCCCTGGCCCCCCAGCCTTGGGGCTCTGGCTCCCCCCGGCGGAATTGGGGGACTGTTTCCTG
 401 ACATCCTGGACAAGGGAAGCCCACTAGAGGCTGGAACAGGACCTCTCCAGCCTCCTCACCAGCACCGTGCCCATCTCAAC
 481 TGGACTTCCCGCTCTCCTTCTCCACCTTCTAGTGCCCGTGGCCGGGGATTCAAAGCCGCCGTTCCCCAGGTCCCTGGGCT
 561 GGGCCCTGACAGGGAGCCGCCCCCCTCCCCATGGTAACCAGGAAGCCCGTTTCATGTTCAGTTGCTTTTGTAGAGGAAGC
 641 AAGGGCTGGGATGGGGACAGCTGTCAATCACAAGCCCTTAAATAAAGCAGCCAGCGCACATCCAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aguguuCAC-UUCAUCACCCu 5'
                ||| : |||||||| 
Target 5' gtgtgtGTGTGTGTAGTGGGt 3'
150 - 170 150.00 -17.00
2
miRNA  3' agUGUUCACUUC-----AUCACCcu 5'
            ||||| ||||     ||| ||  
Target 5' ggACAAGGGAAGCCCACTAGAGGct 3'
408 - 432 114.00 -9.30
3
miRNA  3' agUGUUCACUUCAUCACCCu 5'
            :::|||| ||| ||||| 
Target 5' gtGTGAGTG-AGT-GTGGGt 3'
187 - 204 113.00 -17.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN508073 10 COSMIC
COSN30658517 17 COSMIC
COSN15330369 19 COSMIC
COSN30177747 30 COSMIC
COSN30458741 32 COSMIC
COSN25740259 68 COSMIC
COSN30115701 113 COSMIC
COSN18748126 135 COSMIC
COSN20093521 145 COSMIC
COSN20079303 151 COSMIC
COSN20093520 151 COSMIC
COSN25575528 227 COSMIC
COSN22223116 271 COSMIC
COSN30543680 290 COSMIC
COSN31576227 369 COSMIC
COSN28691827 377 COSMIC
COSN31592928 379 COSMIC
COSN31552557 490 COSMIC
COSN30175810 491 COSMIC
COSN28713207 540 COSMIC
COSN30542032 541 COSMIC
COSN31487471 574 COSMIC
COSN9347621 613 COSMIC
COSN1210764 636 COSMIC
COSN5849305 686 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1008005312 1 dbSNP
rs762626719 2 dbSNP
rs1410810252 8 dbSNP
rs1226314068 12 dbSNP
rs1486414399 13 dbSNP
rs750411110 15 dbSNP
rs1370835715 16 dbSNP
rs765182648 17 dbSNP
rs761698424 18 dbSNP
rs59970096 19 dbSNP
rs1291608598 20 dbSNP
rs576149251 22 dbSNP
rs755531153 22 dbSNP
rs1037953030 23 dbSNP
rs1055077740 26 dbSNP
rs1365835263 28 dbSNP
rs1167530613 31 dbSNP
rs768604233 32 dbSNP
rs761022300 33 dbSNP
rs780366656 33 dbSNP
rs771035160 34 dbSNP
rs367832594 35 dbSNP
rs746254100 38 dbSNP
rs1244364462 40 dbSNP
rs756540087 40 dbSNP
rs1309809580 42 dbSNP
rs1251413377 43 dbSNP
rs375454207 44 dbSNP
rs749757825 48 dbSNP
rs1444298665 49 dbSNP
rs1051849122 50 dbSNP
rs1259774474 55 dbSNP
rs554584553 56 dbSNP
rs1243180294 61 dbSNP
rs1460504986 64 dbSNP
rs1180024217 65 dbSNP
rs1410124583 77 dbSNP
rs1419449635 79 dbSNP
rs150758819 79 dbSNP
rs1162586488 88 dbSNP
rs958578612 94 dbSNP
rs1471039639 97 dbSNP
rs1177457022 98 dbSNP
rs1471692471 104 dbSNP
rs1302864748 113 dbSNP
rs1238933168 114 dbSNP
rs1405376153 114 dbSNP
rs1450600949 115 dbSNP
rs1300379998 122 dbSNP
rs1374775886 123 dbSNP
rs1184468901 132 dbSNP
rs11539250 136 dbSNP
rs767499517 136 dbSNP
rs772966044 136 dbSNP
rs920933696 137 dbSNP
rs983975883 138 dbSNP
rs11539247 139 dbSNP
rs1457452798 139 dbSNP
rs1207494448 140 dbSNP
rs1234518628 140 dbSNP
rs11539251 141 dbSNP
rs1236549551 142 dbSNP
rs1176554120 143 dbSNP
rs1200658943 144 dbSNP
rs1249296423 145 dbSNP
rs1177388511 146 dbSNP
rs951331014 146 dbSNP
rs547546794 147 dbSNP
rs1025412040 150 dbSNP
rs1355194839 150 dbSNP
rs914186125 151 dbSNP
rs976592016 153 dbSNP
rs1358922700 154 dbSNP
rs991180627 155 dbSNP
rs1405980167 158 dbSNP
rs1452950225 160 dbSNP
rs1375740814 163 dbSNP
rs1188540938 164 dbSNP
rs1199961586 164 dbSNP
rs1203671023 164 dbSNP
rs1217128003 164 dbSNP
rs1268425931 164 dbSNP
rs1274416061 164 dbSNP
rs1302862508 164 dbSNP
rs1318297769 164 dbSNP
rs1344539716 164 dbSNP
rs1361570444 164 dbSNP
rs1420260252 164 dbSNP
rs1421949142 164 dbSNP
rs1441581663 164 dbSNP
rs1471225327 164 dbSNP
rs1477127498 164 dbSNP
rs1490769622 164 dbSNP
rs1491324321 164 dbSNP
rs57015096 164 dbSNP
rs60569640 164 dbSNP
rs747629503 164 dbSNP
rs751385841 164 dbSNP
rs762569416 164 dbSNP
rs765495158 164 dbSNP
rs1290713155 165 dbSNP
rs1491167048 165 dbSNP
rs746960407 165 dbSNP
rs764641469 165 dbSNP
rs958843743 165 dbSNP
rs1328840581 168 dbSNP
rs1449679625 168 dbSNP
rs532757379 169 dbSNP
rs1448422835 170 dbSNP
rs1354550313 171 dbSNP
rs928555299 174 dbSNP
rs571708810 175 dbSNP
rs1163543793 177 dbSNP
rs1387178194 177 dbSNP
rs1445696612 177 dbSNP
rs1412009110 180 dbSNP
rs376693477 180 dbSNP
rs975073688 180 dbSNP
rs951224274 182 dbSNP
rs1317883372 190 dbSNP
rs112156914 192 dbSNP
rs1246564791 192 dbSNP
rs1353955846 196 dbSNP
rs966143933 196 dbSNP
rs1225320300 199 dbSNP
rs142215736 200 dbSNP
rs200983118 200 dbSNP
rs1446582782 202 dbSNP
rs1207063014 204 dbSNP
rs182003556 206 dbSNP
rs1461842772 207 dbSNP
rs1183491721 208 dbSNP
rs1236271237 208 dbSNP
rs1180741987 212 dbSNP
rs1471357274 212 dbSNP
rs994027761 215 dbSNP
rs1456346183 219 dbSNP
rs1481001507 223 dbSNP
rs1407631448 230 dbSNP
rs1452788204 234 dbSNP
rs1333426877 235 dbSNP
rs963496286 236 dbSNP
rs889091312 239 dbSNP
rs1033023117 243 dbSNP
rs1016644822 248 dbSNP
rs1000435653 249 dbSNP
rs1220025728 253 dbSNP
rs189353017 256 dbSNP
rs1007569798 257 dbSNP
rs1293099529 258 dbSNP
rs759908251 259 dbSNP
rs1439999445 260 dbSNP
rs1351941728 264 dbSNP
rs1041902430 265 dbSNP
rs889341821 268 dbSNP
rs950229356 269 dbSNP
rs1471845837 271 dbSNP
rs1225057032 277 dbSNP
rs1051989303 281 dbSNP
rs1171425238 283 dbSNP
rs895988981 290 dbSNP
rs1411552961 311 dbSNP
rs997625874 312 dbSNP
rs747249096 318 dbSNP
rs1346447239 320 dbSNP
rs537913015 320 dbSNP
rs1232823188 324 dbSNP
rs1041873456 331 dbSNP
rs1367430195 331 dbSNP
rs1341592367 336 dbSNP
rs1196866861 338 dbSNP
rs1303679531 339 dbSNP
rs1225260964 345 dbSNP
rs1418943330 346 dbSNP
rs947093172 348 dbSNP
rs1197763017 351 dbSNP
rs770554948 354 dbSNP
rs914342944 356 dbSNP
rs1055846095 361 dbSNP
rs866460773 370 dbSNP
rs1427562181 373 dbSNP
rs1304665636 374 dbSNP
rs532093181 375 dbSNP
rs1419839838 378 dbSNP
rs370295417 379 dbSNP
rs542680135 383 dbSNP
rs981392620 388 dbSNP
rs1297493141 397 dbSNP
rs951190033 405 dbSNP
rs1248811919 412 dbSNP
rs527272777 417 dbSNP
rs1189584729 421 dbSNP
rs773466266 422 dbSNP
rs918382242 428 dbSNP
rs1488371119 432 dbSNP
rs973939040 443 dbSNP
rs868192788 447 dbSNP
rs772365492 455 dbSNP
rs1448217854 460 dbSNP
rs1193347754 461 dbSNP
rs1389021928 463 dbSNP
rs963761464 466 dbSNP
rs1165425818 467 dbSNP
rs1385613067 467 dbSNP
rs1016367201 470 dbSNP
rs1007954611 481 dbSNP
rs953407931 485 dbSNP
rs1216511940 488 dbSNP
rs1032993271 490 dbSNP
rs1487521269 491 dbSNP
rs8606 493 dbSNP
rs903192064 502 dbSNP
rs544735708 503 dbSNP
rs1363157530 505 dbSNP
rs1248745593 514 dbSNP
rs997685859 517 dbSNP
rs903454085 518 dbSNP
rs1243157668 523 dbSNP
rs114125224 524 dbSNP
rs1014528684 533 dbSNP
rs1011767265 537 dbSNP
rs369309792 538 dbSNP
rs72620552 540 dbSNP
rs755491386 541 dbSNP
rs906906270 544 dbSNP
rs1045426780 547 dbSNP
rs1365328178 549 dbSNP
rs929842692 554 dbSNP
rs1454467449 555 dbSNP
rs918518245 558 dbSNP
rs1399256365 563 dbSNP
rs1386515071 564 dbSNP
rs974289671 570 dbSNP
rs1338169402 571 dbSNP
rs1379152731 574 dbSNP
rs769412320 578 dbSNP
rs1309514440 579 dbSNP
rs941227191 582 dbSNP
rs888233810 583 dbSNP
rs1267149414 584 dbSNP
rs1358852871 585 dbSNP
rs372877562 586 dbSNP
rs1326459975 587 dbSNP
rs1205085212 591 dbSNP
rs1174202536 599 dbSNP
rs185679471 603 dbSNP
rs1048039253 604 dbSNP
rs1252347956 605 dbSNP
rs778731994 608 dbSNP
rs929609156 609 dbSNP
rs1410115463 611 dbSNP
rs1177170446 614 dbSNP
rs918253677 619 dbSNP
rs1265935323 621 dbSNP
rs1187525175 627 dbSNP
rs1483123016 632 dbSNP
rs1374481882 635 dbSNP
rs1409676813 636 dbSNP
rs1255124358 638 dbSNP
rs1046436 641 dbSNP
rs555218919 642 dbSNP
rs1348183729 656 dbSNP
rs1279440386 666 dbSNP
rs535489486 669 dbSNP
rs1343559410 678 dbSNP
rs943981819 680 dbSNP
rs1251364803 683 dbSNP
rs756639865 687 dbSNP
rs141367113 688 dbSNP
rs1229434842 691 dbSNP
rs1204248635 694 dbSNP
rs1203213733 695 dbSNP
rs1481501165 696 dbSNP
rs3180421 699 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048188. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_ptb_knockdown ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' aguguuCAC-UUCAUCAcccu 5'
                ||| : |||||    
Target 5' guguguGUGUGUGUAGU---- 3'
6 - 22
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_032377 | 3UTR | CAGAGGACCCGCCCCCUGAGCAGCCCCGCGUACUGUGGAUCCAGCUGUUCGGUUCUGGUCCAGAGACAUUCCAGGGGUCCAGGGUGUGGGUCCUGGGCUGUCACAGCCGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUAGUGGGUGUGCGUGUGGGUGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_032377 | 3UTR | UGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUAGUGGGUGUGCGUGUGGGUGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_032377 | 3UTR | UGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUAGUGGGUGUGCGUGUGGGUGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_032377 | 3UTR | CAGCCGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUAGUGGGUGUGCGUGUGGGUGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_032377 | 3UTR | GCCGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUAGUGGGUGUGCGUGUGGGUGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_032377 | 3UTR | UGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUAGUGGGUGUGCGUGUGGGUGUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1048188
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_ptb_knockdown
Location of target site ENST00000252445.3 | 3UTR | UGUGUGUGUGUGUGUGUGUAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000252445.3 | 3UTR | CACAGCCGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4301 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT081134 LDLR low density lipoprotein receptor 2 4
MIRT090911 ARHGEF26 Rho guanine nucleotide exchange factor 26 2 2
MIRT229436 MECP2 methyl-CpG binding protein 2 2 2
MIRT274717 CPSF6 cleavage and polyadenylation specific factor 6 2 2
MIRT350957 BACH1 BTB domain and CNC homolog 1 2 2
MIRT386722 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT446022 PEX3 peroxisomal biogenesis factor 3 2 2
MIRT481303 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 14
MIRT483959 ZNF354B zinc finger protein 354B 2 6
MIRT495667 TUBAL3 tubulin alpha like 3 2 2
MIRT496554 TBX15 T-box 15 2 2
MIRT497702 ARL6IP6 ADP ribosylation factor like GTPase 6 interacting protein 6 2 2
MIRT498105 RMND5A required for meiotic nuclear division 5 homolog A 2 2
MIRT512535 SEMA4D semaphorin 4D 2 2
MIRT512556 MFN2 mitofusin 2 2 6
MIRT521465 RABGAP1 RAB GTPase activating protein 1 2 6
MIRT526236 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT526743 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527578 BRD7 bromodomain containing 7 2 4
MIRT528038 WT1 Wilms tumor 1 2 2
MIRT528267 GPRIN2 G protein regulated inducer of neurite outgrowth 2 2 2
MIRT528505 HTR7 5-hydroxytryptamine receptor 7 2 4
MIRT528758 RPS27 ribosomal protein S27 2 6
MIRT528999 IPO9 importin 9 2 2
MIRT529701 MRPL30 mitochondrial ribosomal protein L30 2 2
MIRT529781 C17orf82 chromosome 17 open reading frame 82 2 2
MIRT533797 TMEM119 transmembrane protein 119 2 6
MIRT535308 PHF12 PHD finger protein 12 2 2
MIRT535917 MKL2 MKL1/myocardin like 2 2 2
MIRT544892 OSBPL1A oxysterol binding protein like 1A 2 2
MIRT555423 PPIC peptidylprolyl isomerase C 2 2
MIRT562068 KLHL15 kelch like family member 15 2 2
MIRT565623 SLC31A1 solute carrier family 31 member 1 2 2
MIRT565661 SIX1 SIX homeobox 1 2 2
MIRT570138 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT571045 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT621232 LMAN1 lectin, mannose binding 1 2 2
MIRT622272 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT623844 GAN gigaxonin 2 2
MIRT626158 NFYA nuclear transcription factor Y subunit alpha 2 2
MIRT626464 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT632087 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT637243 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT642710 FGFR1OP2 FGFR1 oncogene partner 2 2 2
MIRT643611 KANSL3 KAT8 regulatory NSL complex subunit 3 2 2
MIRT644270 PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 2 2
MIRT645470 SPIN3 spindlin family member 3 2 2
MIRT649193 DNPEP aspartyl aminopeptidase 2 2
MIRT650776 POP4 POP4 homolog, ribonuclease P/MRP subunit 2 2
MIRT651345 ZC2HC1C zinc finger C2HC-type containing 1C 2 2
MIRT652237 TRAPPC3L trafficking protein particle complex 3 like 2 2
MIRT652587 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT654591 PURA purine rich element binding protein A 2 2
MIRT654649 PTAFR platelet activating factor receptor 2 2
MIRT656842 KLF7 Kruppel like factor 7 2 2
MIRT657209 IKZF2 IKAROS family zinc finger 2 2 2
MIRT658513 ETV3 ETS variant 3 2 2
MIRT659448 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT668816 CYLD CYLD lysine 63 deubiquitinase 2 2
MIRT669067 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT677711 ELOF1 elongation factor 1 homolog 2 4
MIRT687146 PTPN12 protein tyrosine phosphatase, non-receptor type 12 2 2
MIRT698498 THOC2 THO complex 2 2 2
MIRT707930 PPP1R3D protein phosphatase 1 regulatory subunit 3D 4 2
MIRT708737 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT710031 POLL DNA polymerase lambda 2 2
MIRT712175 STK4 serine/threonine kinase 4 2 2
MIRT715297 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT716892 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT717378 RBM41 RNA binding motif protein 41 2 2
MIRT718082 CLIC5 chloride intracellular channel 5 2 2
MIRT718721 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT719152 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719224 CAMK4 calcium/calmodulin dependent protein kinase IV 2 2
MIRT719528 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT719861 KLF2 Kruppel like factor 2 2 2
MIRT720326 CAMK2G calcium/calmodulin dependent protein kinase II gamma 2 2
MIRT721596 SREBF1 sterol regulatory element binding transcription factor 1 2 2
MIRT722020 NEBL nebulette 2 2
MIRT722484 QSOX1 quiescin sulfhydryl oxidase 1 2 2
MIRT722614 TEAD1 TEA domain transcription factor 1 2 2
MIRT723664 RPTN repetin 2 2
MIRT723939 SVOP SV2 related protein 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive High Hepatocellular Carcinoma cell line (Hep3B, 97L)
hsa-miR-4301 Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-4301 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-4301 Methotrexate 126941 NSC740 approved sensitive cell line (W1)
hsa-mir-4301 Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-miR-4301 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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