pre-miRNA Information
pre-miRNA hsa-mir-23a   
Genomic Coordinates chr19: 13836587 - 13836659
Synonyms MIRN23A, hsa-mir-23a, miRNA23A, MIR23A
Description Homo sapiens miR-23a stem-loop
Comment This miRNA was previously named miR-23 . This finding was later retracted after the discovery that the regulated gene was human homolog of ES1 (HES1), whose function is unknown.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-23a-5p
Sequence 9| GGGGUUCCUGGGGAUGGGAUUU |30
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs748509260 12 dbSNP
rs1205403719 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PNPLA3   
Synonyms ADPN, C22orf20, iPLA(2)epsilon
Description patatin like phospholipase domain containing 3
Transcript NM_025225   
Expression
Putative miRNA Targets on PNPLA3
3'UTR of PNPLA3
(miRNA target sites are highlighted)
>PNPLA3|NM_025225|3'UTR
   1 GTCACTTGAGGAGGCGAGTCTAGCAGATTCTTTCAGAGGTGCTAAAGTTTCCCATCTTTGTGCAGCTACCTCCGCATTGC
  81 TGTGTAGTGACCCCTGCCTGTGACGTGGAGGATCCCAGCCTCTGAGCTGAGTTGGTTTTATGAAAAGCTAGGAAGCAACC
 161 TTTCGCCTGTGCAGCGGTCCAGCACTTAACTCTAATACATCAGCATGCGTTAATTCAGCTGGTTGGGAAATGACACCAGG
 241 AAGCCCAGTGCAGAGGGTCCCTTACTGACTGTTTCGTGGCCCTATTAATGGTCAGACTGTTCCAGCATGAGGTTCTTAGA
 321 ATGACAGGTGTTTGGATGGGTGGGGGCCTTGTGATGGGGGGTAGGCTGGCCCATGTGTGATCTTGTGGGGTGGAGGGAAG
 401 AGAATAGCATGATCCCACTTCCCCATGCTGTGGGAAGGGGTGCAGTTCGTCCCCAAGAACGACACTGCCTGTCAGGTGGT
 481 CTGCAAAGATGATAACCTTGACTACTAAAAACGTCTCCATGGCGGGGGTAACAAGATGATAATCTACTTAATTTTAGAAC
 561 ACCTTTTTCACCTAACTAAAATAATGTTTAAAGAGTTTTGTATAAAAATGTAAGGAAGCGTTGTTACCTGTTGAATTTTG
 641 TATTATGTGAATCAGTGAGATGTTAGTAGAATAAGCCTTAAAAAAAAAAAAATCGGTTGGGTGCAGTGGCACACGGCTGT
 721 AATCCCAGCACTTTGGGAGGCCAAGGTTGGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGTCTGGCCAACATAGCAAA
 801 ACCCTGTCTCTACTAAAAATACAAAAATTATCTGGGCATGGTGGTGCATGCCTGTAATCCCAGCTATTCGGAAGGCTGAG
 881 GCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCGGTGAGCTGAGATTGCACCATTTCATTCCAGCCTGGGCAACAT
 961 GAGTGAAAGTCTGACTCAAAAAAAAAAAATTTAAAAAACAAAATAATCTAGTGTGCAGGGCATTCACCTCAGCCCCCCAG
1041 GCAGGAGCCAAGCACAGCAGGAGCTTCCGCCTCCTCTCCACTGGAGCACACAACTTGAACCTGGCTTATTTTCTGCAGGG
1121 ACCAGCCCCACATGGTCAGTGAGTTTCTCCCCATGTGTGGCGATGAGAGAGTGTAGAAATAAAGAC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uuUAGGGUAGGG------GUCCUUGGgg 5'
            | |:|| |||      |||||:||  
Target 5' tcACCTCAGCCCCCCAGGCAGGAGCCaa 3'
1024 - 1051 126.00 -20.90
2
miRNA  3' uuuaggguaGGGGUCCUUGGGg 5'
                   | ||||||| || 
Target 5' gggaaatgaCACCAGGAAGCCc 3'
225 - 246 125.00 -19.00
3
miRNA  3' uuUAGGGUAGGGGUCCUUGGgg 5'
            ||::  ||: ||||:|||  
Target 5' ttATTT--TCTGCAGGGACCag 3'
1106 - 1125 124.00 -16.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
341948 20 ClinVar
341949 64 ClinVar
341950 72 ClinVar
341951 142 ClinVar
899690 177 ClinVar
899691 223 ClinVar
899692 276 ClinVar
899693 347 ClinVar
900834 394 ClinVar
341952 430 ClinVar
900835 449 ClinVar
341953 627 ClinVar
341954 680 ClinVar
341955 708 ClinVar
341956 748 ClinVar
900836 761 ClinVar
900837 813 ClinVar
341957 890 ClinVar
902513 919 ClinVar
341958 961 ClinVar
341959 978 ClinVar
341960 978 ClinVar
341961 978 ClinVar
341962 991 ClinVar
341963 1069 ClinVar
341964 1077 ClinVar
341965 1091 ClinVar
341966 1176 ClinVar
COSN30491623 12 COSMIC
COSN30151860 17 COSMIC
COSN31488287 35 COSMIC
COSN30499931 60 COSMIC
COSN26727695 64 COSMIC
COSN24292758 75 COSMIC
COSN30494745 75 COSMIC
COSN14666843 91 COSMIC
COSN20080134 100 COSMIC
COSN23435614 105 COSMIC
COSN30466144 116 COSMIC
COSN20080195 178 COSMIC
COSN22217195 210 COSMIC
COSN31507168 261 COSMIC
COSN19705559 276 COSMIC
COSN31565778 292 COSMIC
COSN30478530 304 COSMIC
COSN31563913 313 COSMIC
COSN31597904 328 COSMIC
COSN17558000 336 COSMIC
COSN31510639 361 COSMIC
COSN30180608 368 COSMIC
COSN30480702 380 COSMIC
COSN28841205 393 COSMIC
COSN31600427 403 COSMIC
COSN19666514 411 COSMIC
COSN30153288 424 COSMIC
COSN18744029 430 COSMIC
COSN30541922 434 COSMIC
COSN30180351 435 COSMIC
COSN26650032 440 COSMIC
COSN30455974 449 COSMIC
COSN30190512 450 COSMIC
COSN31522117 498 COSMIC
COSN24341867 530 COSMIC
COSN28185801 564 COSMIC
COSN8019715 595 COSMIC
COSN1262675 693 COSMIC
COSN27198768 693 COSMIC
COSN31959851 910 COSMIC
COSN16528535 921 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs751698167 5 dbSNP
rs140909509 8 dbSNP
rs368899768 16 dbSNP
rs753209557 17 dbSNP
rs569255289 20 dbSNP
rs373173858 31 dbSNP
rs745563266 35 dbSNP
rs1292699521 38 dbSNP
rs1317629649 39 dbSNP
rs1325693953 46 dbSNP
rs1218174375 51 dbSNP
rs6006461 52 dbSNP
rs2294919 64 dbSNP
rs557722575 71 dbSNP
rs886057601 72 dbSNP
rs760429303 74 dbSNP
rs1192713398 81 dbSNP
rs995874006 84 dbSNP
rs1248375948 94 dbSNP
rs913043512 95 dbSNP
rs1027790067 105 dbSNP
rs539980744 106 dbSNP
rs947173899 112 dbSNP
rs1206535496 120 dbSNP
rs115043594 133 dbSNP
rs886057602 142 dbSNP
rs1234019413 145 dbSNP
rs1005088043 148 dbSNP
rs927153737 151 dbSNP
rs1185371228 153 dbSNP
rs1325962347 155 dbSNP
rs866388723 160 dbSNP
rs1057199550 165 dbSNP
rs763503205 166 dbSNP
rs1427238471 169 dbSNP
rs570274837 171 dbSNP
rs760758882 174 dbSNP
rs1046784151 176 dbSNP
rs1410221181 177 dbSNP
rs1195199019 181 dbSNP
rs374162736 193 dbSNP
rs1256333645 194 dbSNP
rs1005638170 202 dbSNP
rs971241243 204 dbSNP
rs981304572 205 dbSNP
rs927240871 209 dbSNP
rs1175924737 210 dbSNP
rs537933350 223 dbSNP
rs1407323105 232 dbSNP
rs1018405022 237 dbSNP
rs879815096 238 dbSNP
rs990854737 244 dbSNP
rs964253614 248 dbSNP
rs998485435 252 dbSNP
rs554741738 254 dbSNP
rs746933163 255 dbSNP
rs1030056599 256 dbSNP
rs915272140 257 dbSNP
rs946829495 259 dbSNP
rs1416464071 262 dbSNP
rs1185390998 268 dbSNP
rs956759815 272 dbSNP
rs1473537628 275 dbSNP
rs537338257 276 dbSNP
rs188355869 277 dbSNP
rs1022354157 280 dbSNP
rs968127063 281 dbSNP
rs1256681722 282 dbSNP
rs1200653238 283 dbSNP
rs1384546754 291 dbSNP
rs1292704833 294 dbSNP
rs113793491 304 dbSNP
rs1485418741 306 dbSNP
rs944880800 308 dbSNP
rs1211251540 311 dbSNP
rs1259369358 312 dbSNP
rs1381602959 313 dbSNP
rs35941472 319 dbSNP
rs1284637277 320 dbSNP
rs1474156280 325 dbSNP
rs759422827 342 dbSNP
rs554000765 347 dbSNP
rs41278869 348 dbSNP
rs769538246 349 dbSNP
rs1344310869 355 dbSNP
rs765261217 356 dbSNP
rs773059060 356 dbSNP
rs1434957290 359 dbSNP
rs1313809806 361 dbSNP
rs1377678985 362 dbSNP
rs1413432816 363 dbSNP
rs900771057 364 dbSNP
rs1393102498 366 dbSNP
rs762774166 367 dbSNP
rs1374119986 368 dbSNP
rs1225595362 369 dbSNP
rs766725479 370 dbSNP
rs774667171 371 dbSNP
rs1235325843 372 dbSNP
rs1282144841 373 dbSNP
rs759720292 374 dbSNP
rs1469923513 378 dbSNP
rs1210040977 386 dbSNP
rs1233441536 388 dbSNP
rs1181085543 389 dbSNP
rs767604048 390 dbSNP
rs1272690591 393 dbSNP
rs41278871 394 dbSNP
rs764431110 396 dbSNP
rs1454411714 397 dbSNP
rs1047175294 400 dbSNP
rs1304114971 403 dbSNP
rs754233486 406 dbSNP
rs757559564 407 dbSNP
rs1433305467 410 dbSNP
rs779699624 414 dbSNP
rs1290836332 418 dbSNP
rs1355554715 420 dbSNP
rs1223384208 422 dbSNP
rs1479469102 427 dbSNP
rs41278873 430 dbSNP
rs971190609 434 dbSNP
rs1370137368 439 dbSNP
rs1002673399 442 dbSNP
rs1458965880 444 dbSNP
rs555962274 449 dbSNP
rs1166572744 450 dbSNP
rs958618161 458 dbSNP
rs991194529 459 dbSNP
rs144704231 461 dbSNP
rs751930941 462 dbSNP
rs1189599068 464 dbSNP
rs978184328 466 dbSNP
rs1247325495 467 dbSNP
rs1215338115 471 dbSNP
rs1351710218 474 dbSNP
rs1411059716 483 dbSNP
rs900032711 489 dbSNP
rs998829793 498 dbSNP
rs1371894194 507 dbSNP
rs192591729 512 dbSNP
rs755361902 513 dbSNP
rs1388391965 514 dbSNP
rs1367727370 518 dbSNP
rs574120250 524 dbSNP
rs561867145 525 dbSNP
rs1362060453 528 dbSNP
rs1300479811 529 dbSNP
rs1033227152 530 dbSNP
rs976269034 537 dbSNP
rs1420673120 540 dbSNP
rs1394810242 547 dbSNP
rs1174612241 561 dbSNP
rs1268237458 561 dbSNP
rs553777736 562 dbSNP
rs1185992797 563 dbSNP
rs547395359 564 dbSNP
rs932242011 566 dbSNP
rs1049815415 570 dbSNP
rs1274952375 573 dbSNP
rs887430439 575 dbSNP
rs940377968 582 dbSNP
rs1036082558 588 dbSNP
rs906978774 596 dbSNP
rs1312640744 601 dbSNP
rs752447214 606 dbSNP
rs1294300762 609 dbSNP
rs1489880286 611 dbSNP
rs1342045805 613 dbSNP
rs1298461907 614 dbSNP
rs1221926169 620 dbSNP
rs1301403953 621 dbSNP
rs1401951597 621 dbSNP
rs564752977 627 dbSNP
rs376197639 631 dbSNP
rs958538008 636 dbSNP
rs1409058329 643 dbSNP
rs762500400 648 dbSNP
rs1476869163 650 dbSNP
rs1372904114 655 dbSNP
rs1011490387 659 dbSNP
rs1474962802 662 dbSNP
rs533452613 664 dbSNP
rs1383858418 666 dbSNP
rs1278203630 680 dbSNP
rs1328909110 680 dbSNP
rs1483561592 680 dbSNP
rs397716964 680 dbSNP
rs993091240 681 dbSNP
rs1424583119 693 dbSNP
rs1162440648 695 dbSNP
rs1021986198 696 dbSNP
rs1388181388 698 dbSNP
rs1315729303 699 dbSNP
rs1325652436 702 dbSNP
rs769365899 703 dbSNP
rs957566883 703 dbSNP
rs917136614 704 dbSNP
rs2008451 708 dbSNP
rs1331280259 709 dbSNP
rs978512149 712 dbSNP
rs1357260853 715 dbSNP
rs982459432 718 dbSNP
rs1457645276 723 dbSNP
rs1366928993 731 dbSNP
rs1189422505 736 dbSNP
rs1424202869 746 dbSNP
rs62228000 748 dbSNP
rs1176707005 749 dbSNP
rs1258213023 750 dbSNP
rs1212518689 751 dbSNP
rs1353872334 756 dbSNP
rs545853993 761 dbSNP
rs1244999285 780 dbSNP
rs555738581 786 dbSNP
rs922089448 788 dbSNP
rs1308894616 792 dbSNP
rs185082280 803 dbSNP
rs985045161 804 dbSNP
rs189936476 809 dbSNP
rs1447943968 811 dbSNP
rs1039455088 827 dbSNP
rs899604338 835 dbSNP
rs1195863804 839 dbSNP
rs934151481 842 dbSNP
rs909468211 844 dbSNP
rs940344852 845 dbSNP
rs1051703056 846 dbSNP
rs1444603453 849 dbSNP
rs1156602570 853 dbSNP
rs1164727788 855 dbSNP
rs1385337134 856 dbSNP
rs1035989249 865 dbSNP
rs892684108 868 dbSNP
rs1197604543 870 dbSNP
rs1449398773 871 dbSNP
rs1458941773 876 dbSNP
rs1010273953 878 dbSNP
rs1022287765 881 dbSNP
rs1156447595 884 dbSNP
rs1810508 890 dbSNP
rs1400914132 892 dbSNP
rs1002217924 893 dbSNP
rs1380270362 900 dbSNP
rs757162821 901 dbSNP
rs1055509024 909 dbSNP
rs961080452 910 dbSNP
rs1014056990 912 dbSNP
rs1342362244 914 dbSNP
rs1325542668 917 dbSNP
rs778859111 918 dbSNP
rs146578673 919 dbSNP
rs1011854176 921 dbSNP
rs1421269001 925 dbSNP
rs771711260 929 dbSNP
rs1021516200 938 dbSNP
rs1351746285 943 dbSNP
rs886057603 961 dbSNP
rs111437790 967 dbSNP
rs1261693644 971 dbSNP
rs1198936497 977 dbSNP
rs1461109960 977 dbSNP
rs1287107613 978 dbSNP
rs1487795537 978 dbSNP
rs3083314 978 dbSNP
rs397775086 990 dbSNP
rs903118334 990 dbSNP
rs886057604 991 dbSNP
rs1031018930 993 dbSNP
rs568178378 994 dbSNP
rs576581039 995 dbSNP
rs962322685 998 dbSNP
rs775363988 999 dbSNP
rs1362684313 1001 dbSNP
rs976144798 1011 dbSNP
rs975066388 1013 dbSNP
rs533730254 1016 dbSNP
rs1412745794 1021 dbSNP
rs1404259891 1023 dbSNP
rs1160878344 1028 dbSNP
rs953541563 1031 dbSNP
rs920983333 1035 dbSNP
rs985381354 1037 dbSNP
rs553492287 1038 dbSNP
rs962616205 1039 dbSNP
rs576819835 1041 dbSNP
rs1209855457 1042 dbSNP
rs1441236149 1044 dbSNP
rs1281326585 1059 dbSNP
rs1204815046 1063 dbSNP
rs1469051339 1064 dbSNP
rs746640250 1069 dbSNP
rs928301951 1070 dbSNP
rs1220707468 1074 dbSNP
rs886057605 1077 dbSNP
rs938374402 1078 dbSNP
rs1051264894 1079 dbSNP
rs1342242593 1086 dbSNP
rs1336382003 1090 dbSNP
rs9626058 1091 dbSNP
rs1464977171 1095 dbSNP
rs776260900 1099 dbSNP
rs1397520602 1101 dbSNP
rs1281550106 1102 dbSNP
rs568260707 1110 dbSNP
rs1181692349 1114 dbSNP
rs1043972520 1126 dbSNP
rs1472029432 1132 dbSNP
rs1239535380 1148 dbSNP
rs556449751 1154 dbSNP
rs904123337 1155 dbSNP
rs1256298827 1156 dbSNP
rs1002168502 1160 dbSNP
rs368751842 1162 dbSNP
rs371817140 1163 dbSNP
rs896562427 1170 dbSNP
rs1358209187 1173 dbSNP
rs529050829 1176 dbSNP
rs1024122843 1190 dbSNP
rs551054893 1195 dbSNP
rs565561364 1196 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uuuaggguaggggucCUUGGgg 5'
                         |||:|  
Target 5' gaggcugaggcaggaGAAUCac 3'
5 - 26
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000216180.3 | 3UTR | CAGGGAGGCUGAGGCAGGAGAAUCACUUGAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE15076 Monocyte-derived dendritic cells -0.981 1.5e-6 -0.750 1.0e-2 9 Click to see details
GSE28544 Breast cancer 0.692 9.0e-5 0.672 1.6e-4 24 Click to see details
GSE19536 Breast cancer 0.125 1.1e-1 0.127 1.0e-1 100 Click to see details
GSE42095 Differentiated embryonic stem cells 0.264 1.1e-1 0.040 4.3e-1 23 Click to see details
GSE26953 Aortic valvular endothelial cells 0.225 1.5e-1 0.143 2.5e-1 24 Click to see details
GSE19783 ER- ER- breast cancer 0.12 1.5e-1 0.161 7.8e-2 79 Click to see details
GSE21687 Ependynoma primary tumors 0.111 1.9e-1 0.097 2.2e-1 64 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.179 2.0e-1 -0.277 9.0e-2 25 Click to see details
GSE38226 Liver fibrosis -0.139 2.7e-1 -0.221 1.7e-1 21 Click to see details
GSE28260 Renal cortex and medulla -0.181 2.8e-1 -0.291 1.7e-1 13 Click to see details
GSE21032 Prostate cancer 0.057 3.0e-1 0.145 9.5e-2 83 Click to see details
GSE19350 CNS germ cell tumors -0.157 3.1e-1 -0.079 4.0e-1 12 Click to see details
GSE32688 Pancreatic cancer -0.084 3.2e-1 -0.170 1.8e-1 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.07 3.7e-1 0.130 2.7e-1 25 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.062 4.0e-1 0.296 1.0e-1 20 Click to see details
GSE19783 ER+ ER+ breast cancer 0.049 4.2e-1 0.017 4.7e-1 20 Click to see details
GSE17498 Multiple myeloma 0.029 4.3e-1 -0.070 3.3e-1 40 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LIHC -0.354 0.01 -0.367 0.01 38 Click to see details
PRAD 0.366 0.06 0.432 0.03 19 Click to see details
KICH 0.317 0.09 0.346 0.07 20 Click to see details
STAD 0.241 0.11 0.251 0.1 28 Click to see details
PCPG 0.931 0.12 1.000 0.5 3 Click to see details
KIRC -0.142 0.14 -0.144 0.13 62 Click to see details
PAAD 0.704 0.15 0.800 0.1 4 Click to see details
CHOL 0.393 0.17 0.190 0.33 8 Click to see details
THCA 0.121 0.18 0.109 0.21 59 Click to see details
COAD -0.367 0.19 -0.548 0.08 8 Click to see details
KIRP 0.152 0.2 0.145 0.21 32 Click to see details
LUAD 0.301 0.22 0.250 0.26 9 Click to see details
HNSC -0.109 0.25 -0.165 0.15 40 Click to see details
UCEC -0.145 0.28 -0.163 0.25 19 Click to see details
BLCA 0.16 0.28 0.162 0.27 16 Click to see details
ESCA 0.126 0.36 0.327 0.16 11 Click to see details
BRCA 0.023 0.42 0.063 0.29 78 Click to see details
CESC -0.209 0.43 -0.500 0.33 3 Click to see details
LUSC -0.011 0.47 -0.031 0.43 38 Click to see details
LUSC -0.011 0.47 -0.031 0.43 38 Click to see details
LUSC -0.011 0.47 -0.031 0.43 38 Click to see details
131 hsa-miR-23a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038958 ATF1 activating transcription factor 1 1 1
MIRT057661 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT395438 NFKBID NFKB inhibitor delta 2 2
MIRT463884 WNT7B Wnt family member 7B 2 4
MIRT475804 HDGF heparin binding growth factor 2 2
MIRT478528 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT479278 CHD4 chromodomain helicase DNA binding protein 4 2 6
MIRT492564 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT500353 ZNF385A zinc finger protein 385A 2 2
MIRT509788 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT511566 HIST3H2BB histone cluster 3 H2B family member b 2 4
MIRT525450 GPATCH2L G-patch domain containing 2 like 2 2
MIRT539558 CNKSR3 CNKSR family member 3 2 4
MIRT540034 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT540225 SAMD5 sterile alpha motif domain containing 5 2 2
MIRT540242 RGS17 regulator of G protein signaling 17 2 2
MIRT540871 ZBTB24 zinc finger and BTB domain containing 24 2 2
MIRT559065 C19orf47 chromosome 19 open reading frame 47 2 4
MIRT560685 HIST1H1T histone cluster 1 H1 family member t 2 2
MIRT565593 SLC35G1 solute carrier family 35 member G1 2 2
MIRT565642 SKI SKI proto-oncogene 2 2
MIRT576747 Tmem127 transmembrane protein 127 2 2
MIRT607712 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT615682 NAV2 neuron navigator 2 2 2
MIRT617337 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT617378 FAM227A family with sequence similarity 227 member A 2 2
MIRT620855 SERPING1 serpin family G member 1 2 2
MIRT625112 SLC1A5 solute carrier family 1 member 5 2 2
MIRT625124 NUP93 nucleoporin 93 2 2
MIRT625898 LINC00632 long intergenic non-protein coding RNA 632 2 2
MIRT626016 XRCC2 X-ray repair cross complementing 2 2 2
MIRT626481 ADAT1 adenosine deaminase, tRNA specific 1 2 2
MIRT626573 MED7 mediator complex subunit 7 2 2
MIRT626814 PRR11 proline rich 11 2 2
MIRT628136 HM13 histocompatibility minor 13 2 2
MIRT630771 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT633133 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT636950 APTX aprataxin 2 2
MIRT637802 GGPS1 geranylgeranyl diphosphate synthase 1 2 2
MIRT638622 GSR glutathione-disulfide reductase 2 4
MIRT642196 SMAGP small cell adhesion glycoprotein 2 2
MIRT645121 HES2 hes family bHLH transcription factor 2 2 2
MIRT645344 AGTPBP1 ATP/GTP binding protein 1 2 2
MIRT646564 ALDH5A1 aldehyde dehydrogenase 5 family member A1 2 2
MIRT649243 TRIM65 tripartite motif containing 65 2 2
MIRT651810 USP49 ubiquitin specific peptidase 49 2 2
MIRT652137 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT652668 TIMELESS timeless circadian clock 2 2
MIRT655894 NEK9 NIMA related kinase 9 2 2
MIRT656564 LYRM7 LYR motif containing 7 2 2
MIRT657194 IKZF3 IKAROS family zinc finger 3 2 2
MIRT657907 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT660207 BMPR1A bone morphogenetic protein receptor type 1A 2 2
MIRT660619 ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2 2
MIRT660826 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT660986 ABHD2 abhydrolase domain containing 2 2 2
MIRT662232 PGBD4 piggyBac transposable element derived 4 2 2
MIRT663691 ZNF347 zinc finger protein 347 2 2
MIRT665577 TUBD1 tubulin delta 1 2 2
MIRT666149 SP2 Sp2 transcription factor 2 2
MIRT666310 SLC22A3 solute carrier family 22 member 3 2 2
MIRT666457 SCRG1 stimulator of chondrogenesis 1 2 2
MIRT667716 KIAA1468 KIAA1468 2 2
MIRT668329 FKBP5 FK506 binding protein 5 2 2
MIRT668370 FBXO47 F-box protein 47 2 2
MIRT669304 C17orf75 chromosome 17 open reading frame 75 2 2
MIRT669538 ALG9 ALG9, alpha-1,2-mannosyltransferase 2 2
MIRT671681 ADK adenosine kinase 2 2
MIRT672177 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT673604 HPSE heparanase 2 2
MIRT673749 ZNF333 zinc finger protein 333 2 2
MIRT674807 FAM229B family with sequence similarity 229 member B 2 2
MIRT675286 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT675391 SVOP SV2 related protein 2 2
MIRT675788 MED28 mediator complex subunit 28 2 2
MIRT676151 OGFOD1 2-oxoglutarate and iron dependent oxygenase domain containing 1 2 2
MIRT676499 GJD3 gap junction protein delta 3 2 2
MIRT676621 CSNK1E casein kinase 1 epsilon 2 2
MIRT676644 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT676711 METTL14 methyltransferase like 14 2 2
MIRT676809 SHROOM4 shroom family member 4 2 2
MIRT677036 FOXO3 forkhead box O3 2 2
MIRT677062 NT5C2 5'-nucleotidase, cytosolic II 2 2
MIRT677086 SMIM15 small integral membrane protein 15 2 2
MIRT677193 MURC caveolae associated protein 4 2 2
MIRT677273 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT677345 POC1A POC1 centriolar protein A 2 2
MIRT677504 SLC10A6 solute carrier family 10 member 6 2 2
MIRT677526 OCIAD2 OCIA domain containing 2 2 2
MIRT677661 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT677727 SSR1 signal sequence receptor subunit 1 2 2
MIRT677803 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT678144 SLC4A4 solute carrier family 4 member 4 2 2
MIRT678376 VTA1 vesicle trafficking 1 2 2
MIRT678708 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT678868 FAM118A family with sequence similarity 118 member A 2 2
MIRT679039 LACTB lactamase beta 2 2
MIRT679081 PURB purine rich element binding protein B 2 2
MIRT679137 SYK spleen associated tyrosine kinase 2 2
MIRT679299 SSBP2 single stranded DNA binding protein 2 2 2
MIRT679741 CABP4 calcium binding protein 4 2 2
MIRT679946 AS3MT arsenite methyltransferase 2 2
MIRT679976 E2F2 E2F transcription factor 2 2 2
MIRT683628 MTO1 mitochondrial tRNA translation optimization 1 2 2
MIRT683901 PSMB9 proteasome subunit beta 9 2 2
MIRT684172 MOG myelin oligodendrocyte glycoprotein 2 2
MIRT684231 C20orf144 chromosome 20 open reading frame 144 2 2
MIRT685403 C1orf158 chromosome 1 open reading frame 158 2 2
MIRT686253 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT687513 NCKAP1 NCK associated protein 1 2 2
MIRT688243 FITM2 fat storage inducing transmembrane protein 2 2 2
MIRT688315 FAM151B family with sequence similarity 151 member B 2 2
MIRT688733 CNDP1 carnosine dipeptidase 1 2 2
MIRT689031 ANGPTL3 angiopoietin like 3 2 2
MIRT698207 TMEM248 transmembrane protein 248 2 2
MIRT699859 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT709954 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT711541 MSH3 mutS homolog 3 2 2
MIRT712077 WDR37 WD repeat domain 37 2 2
MIRT715312 POLR2E RNA polymerase II subunit E 2 2
MIRT715725 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT715748 HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like 2 2
MIRT717604 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT717875 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT718042 NIPAL2 NIPA like domain containing 2 2 2
MIRT718829 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT724037 CAMK2N2 calcium/calmodulin dependent protein kinase II inhibitor 2 2 2
MIRT733305 TNF tumor necrosis factor 1 0
MIRT734941 HSPA1B heat shock protein family A (Hsp70) member 1B 3 0
MIRT737343 IGF2 insulin like growth factor 2 3 0
MIRT737546 PTEN phosphatase and tensin homolog 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-23a 1'-Acetoxychavicol acetate (ACA) NULL 119104 Microarray HN4 cell line 24317043 2014 down-regulated
miR-23a 5-Fluorouracil approved 3385 Quantitative real-time PCR colon cancer cells 17702597 2007 up-regulated
miR-23a Curcumin NULL 969516 Microarray BxPC-3 human pancreatic carcinoma cell line 18347134 2008 up-regulated
miR-23a Enoxacin approved 3229 Quantitative real-time PCR HEK293 cells 18641635 2008 up-regulated
miR-23a 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR endometrial stromal 19088369 2008 down-regulated
miR-23a 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR glandular epithelial cells 19088369 2008 down-regulated
miR-23a Medroxyprogesterone acetate approved 6279 Quantitative real-time PCR endometrial stromal 19088369 2008 down-regulated
miR-23a Medroxyprogesterone acetate approved 6279 Quantitative real-time PCR glandular epithelial cells 19088369 2008 up-regulated
miR-23a 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
miR-23a Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miR-23a Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-23a Bio-Oss NULL NULL Microarray osteoblast-like cell line (MG63) 20224834 2010 up-regulated
miR-23a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-23a 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 up-regulated
miR-23a Trastuzumab approved NULL Microarray BT474 cells 22384020 2012 up-regulated
miR-23a Trastuzumab approved NULL Microarray SKBR3 cells. 22384020 2012 up-regulated
miR-23a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Quantitative real-time PCR thymus 23024791 2012 down-regulated
miR-23a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-23a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 up-regulated
miR-23a Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 up-regualted
miR-23a Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
miR-23a Comfrey NULL 6440495 Microarray rat liver 21370286 2011 up-regulated
miR-23a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-23a Ethanol NULL 702 Quantitative real-time PCR zebrafish embryos 22298809 2012 down-regulated
miR-23a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 up-regulated
miR-23a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 up-regulated
miR-23a Morphine approved 5288826 Microarray human monocyte-derived macrophages (h-mdms) infection with HIV-1 20564181 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive Low Breast Cancer cell line (MDA-MB-231)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (BGC823)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC-7901)
hsa-mir-23a Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-mir-23a Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-23a Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive cell line (OE19)
hsa-mir-23a Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-23a Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive cell line (SGC-7901)
hsa-miR-23a-5p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-23a-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-23a-5p Palbociclib 5330286 NSC758247 approved resistant High Breast Cancer cell line (T47D)
hsa-miR-23a-5p Arsenic trioxide 261004 NSC759274 approved sensitive Low Acute Myeloid Leukemia cell line (U937, Kasumi-1, THP-1, Jurkat E6.1, SUP B15)
hsa-miR-23a-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-23a-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-23a-5p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-23a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-23a-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-23a-5p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-23a-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-23a-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-23a-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-23a-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-23a-5p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-23a-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (MDA-231)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-23a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-23a-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-23a-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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