miRTarBase - #MIRT677979


—
pre-miRNA Information
pre-miRNA hsa-mir-449b   
Genomic Coordinates chr5: 55170646 - 55170742
Description Homo sapiens miR-449b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-449b-5p
Sequence 16| AGGCAGUGUAUUGUUAGCUGGC |37
Evidence Experimental
Experiments Microarray
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN8871076 12 COSMIC
COSN17153496 22 COSMIC
COSN31576772 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322925717 3 dbSNP
rs769526811 10 dbSNP
rs10061133 12 dbSNP
rs1431829587 13 dbSNP
rs778042202 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ITGB3   
Synonyms BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT
Description integrin subunit beta 3
Transcript NM_000212   
Expression
Putative miRNA Targets on ITGB3
3'UTR of ITGB3
(miRNA target sites are highlighted)		 
>ITGB3|NM_000212|3'UTR
   1 TGATAAGCAGTCATCCTCAGATCATTATCAGCCTGTGCCACGATTGCAGGAGTCCCTGCCATCATGTTTACAGAGGACAG
  81 TATTTGTGGGGAGGGATTTGGGGCTCAGAGTGGGGTAGGTTGGGAGAATGTCAGTATGTGGAAGTGTGGGTCTGTGTGTG
 161 TGTATGTGGGGGTCTGTGTGTTTATGTGTGTGTGTTGTGTGTGGGAGTGTGTAATTTAAAATTGTGATGTGTCCTGATAA
 241 GCTGAGCTCCTTAGCCTTTGTCCCAGAATGCCTCCTGCAGGGATTCTTCCTGCTTAGCTTGAGGGTGACTATGGAGCTGA
 321 GCAGGTGTTCTTCATTACCTCAGTGAGAAGCCAGCTTTCCTCATCAGGCCATTGTCCCTGAAGAGAAGGGCAGGGCTGAG
 401 GCCTCTCATTCCAGAGGAAGGGACACCAAGCCTTGGCTCTACCCTGAGTTCATAAATTTATGGTTCTCAGGCCTGACTCT
 481 CAGCAGCTATGGTAGGAACTGCTGGGCTTGGCAGCCCGGGTCATCTGTACCTCTGCCTCCTTTCCCCTCCCTCAGGCCGA
 561 AGGAGGAGTCAGGGAGAGCTGAACTATTAGAGCTGCCTGTGCCTTTTGCCATCCCCTCAACCCAGCTATGGTTCTCTCGC
 641 AAGGGAAGTCCTTGCAAGCTAATTCTTTGACCTGTTGGGAGTGAGGATGTCTGGGCCACTCAGGGGTCATTCATGGCCTG
 721 GGGGATGTACCAGCATCTCCCAGTTCATAATCACAACCCTTCAGATTTGCCTTATTGGCAGCTCTACTCTGGAGGTTTGT
 801 TTAGAAGAAGTGTGTCACCCTTAGGCCAGCACCATCTCTTTACCTCCTAATTCCACACCCTCACTGCTGTAGACATTTGC
 881 TATGAGCTGGGGATGTCTCTCATGACCAAATGCTTTTCCTCAAAGGGAGAGAGTGCTATTGTAGAGCCAGAGGTCTGGCC
 961 CTATGCTTCCGGCCTCCTGTCCCTCATCCATAGCACCTCCACATACCTGGCCCTGTGCCTTGGTGTGCTGTATCCATCCA
1041 TGGGGCTGATTGTATTTACCTTCTACCTCTTGGCTGCCTTGTGAAGGAATTATTCCCATGAGTTGGCTGGGAATAAGTGC
1121 CAGGATGGAATGATGGGTCAGTTGTATCAGCACGTGTGGCCTGTTCTTCTATGGGTTGGACAACCTCATTTTAACTCAGT
1201 CTTTAATCTGAGAGGCCACAGTGCAATTTTATTTTATTTTTCTCATGATGAGGTTTTCTTAACTTAAAAGAACATGTATA
1281 TAAACATGCTTGCATTATATTTGTAAATTTATGTGATGGCAAAGAAGGAGAGCATAGGAAACCACACAGACTTGGGCAGG
1361 GTACAGACACTCCCACTTGGCATCATTCACAGCAAGTCACTGGCCAGTGGCTGGATCTGTGAGGGGCTCTCTCATGATAG
1441 AAGGCTATGGGGATAGATGTGTGGACACATTGGACCTTTCCTGAGGAAGAGGGACTGTTCTTTTGTCCCAGAAAAGCAGT
1521 GGCTCCATTGGTGTTGACATACATCCAACATTAAAAGCCACCCCCAAATGCCCAAGAAAAAAAGAAAGACTTATCAACAT
1601 TTGTTCCATGAGCAGAAAACTGGAGCTCTGGCCTCAGTGTTACAGCTAAATAATCTTTAATTAAGGCAAGTCACTTTCTT
1681 CTTCTTAAAGCTGTTTTCTAGTTTGAGAAATGATGGGATTTTAGCAGCCAGTCTTGAAGGTCTCTTTCAGTATCAACATT
1761 CTAAGATGCTGGGACTTACTGTGTCATCAAATGTGCGGTTAAGATTCTCTGGGATATTGATACTGTTTGTGTTTTTAGTT
1841 GGGAGATCTGAGAGACCTGGCTTTGGCAAGAGCAGATGTCATTCCATATCACCTTTCTCAATGAAAGTCTCATTCTATCC
1921 TCTCTCCAAACCCGTTTTCCAACATTTGTTAATAGTTACGTCTCTCCTGATGTAGCACTTAAGCTTCATTTAGTTATTAT
2001 TTCTTTCTTCACTTTGCACACATTTGCATCCACATATTAGGGAAGAGGAATCCATAAGTAGCTGAAATATCTATTCTGTA
2081 TTATTGTGTTAACATTGAGAATAAGCCTTGGAATTAGATATGGGGCAATGACTGAGCCCTGTCTCACCCATGGATTACTC
2161 CTTACTGTAGGGAATGGCAGTATGGTAGAGGGATAAATAGGGGGCGGGGAGGGATAGTCATGGATCCAAGAAGTCCTTAG
2241 AAATAGTGGCAGGGAACAGGTGTGGAAGCTCATGCCTGTAATTATAACCTTCAGCTACTAAGACAGGTGTGGTGGCTCAC
2321 GCCTGTGATTATAATCTTCAGTTACTAAGACAGAGTCCATGAGAGTGTTAATGGGACATTTTCTTTAGATAAGATGTTTT
2401 ATATGAAGAAACTGTATCAAAGGGGGAAGAAAATGTATTTAACAGGTGAATCAAATCAGGAATCTTGTCTGAGCTACTGG
2481 AATGAAGTTCACAGGTCTTGAAGACCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cggucGAUU--GUUAU----GUGACGGa 5'
               ||||  | | |    ||||||: 
Target 5' acctcCTAATTCCACACCCTCACTGCTg 3'
 842 - 869 129.00 -12.34
2 
miRNA  3' cgGUCGAUUGUUAUGUGACGGa 5'
            |||   |||: ||||| || 
Target 5' ggCAGGGTACAG-ACACTCCCa 3'
 1355 - 1375 127.00 -12.40
3 
miRNA  3' cggucgaUUGUUAUGUGACGGa 5'
                 |:|||  ||||| | 
Target 5' cattcacAGCAAGTCACTGGCc 3'
 1384 - 1405 123.00 -12.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
323875 13 ClinVar
890180 90 ClinVar
890181 91 ClinVar
323876 127 ClinVar
890182 186 ClinVar
323877 272 ClinVar
323878 440 ClinVar
323879 461 ClinVar
323880 481 ClinVar
323881 518 ClinVar
323882 553 ClinVar
323883 640 ClinVar
323884 672 ClinVar
323885 675 ClinVar
323886 700 ClinVar
323887 714 ClinVar
891994 740 ClinVar
323888 759 ClinVar
323889 803 ClinVar
323890 920 ClinVar
323891 1017 ClinVar
891995 1042 ClinVar
323892 1155 ClinVar
323893 1226 ClinVar
891996 1293 ClinVar
323894 1332 ClinVar
889581 1350 ClinVar
323895 1480 ClinVar
889582 1506 ClinVar
323896 1528 ClinVar
323897 1543 ClinVar
889583 1586 ClinVar
323898 1715 ClinVar
323899 1805 ClinVar
323900 1818 ClinVar
323901 1933 ClinVar
890232 1960 ClinVar
323902 1961 ClinVar
323903 1986 ClinVar
323904 2031 ClinVar
890233 2082 ClinVar
890799 2118 ClinVar
890800 2264 ClinVar
323905 2328 ClinVar
890801 2405 ClinVar
323906 2456 ClinVar
COSN31498165 30 COSMIC
COSN26804663 56 COSMIC
COSN30469272 90 COSMIC
COSN31506121 129 COSMIC
COSN31549690 155 COSMIC
COSN30538486 461 COSMIC
COSN23746136 467 COSMIC
COSN32055905 553 COSMIC
COSN25813381 557 COSMIC
COSN32058693 566 COSMIC
COSN8603285 676 COSMIC
COSN31572682 708 COSMIC
COSN31481739 761 COSMIC
COSN7436696 872 COSMIC
COSN31489437 922 COSMIC
COSN31603620 928 COSMIC
COSN31596421 1160 COSMIC
COSN31544938 1213 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1377012036 1 dbSNP
rs1383872833 5 dbSNP
rs1298212424 9 dbSNP
rs776642181 11 dbSNP
rs763559573 13 dbSNP
rs1225892446 15 dbSNP
rs1013241743 23 dbSNP
rs1312420590 33 dbSNP
rs1208902962 34 dbSNP
rs765015399 39 dbSNP
rs377164992 40 dbSNP
rs1051452 42 dbSNP
rs370002541 43 dbSNP
rs375621583 56 dbSNP
rs762714810 62 dbSNP
rs1332935759 65 dbSNP
rs1323909427 81 dbSNP
rs1480452446 82 dbSNP
rs1175262261 89 dbSNP
rs1252473304 90 dbSNP
rs1173347828 107 dbSNP
rs1464374789 109 dbSNP
rs971431753 110 dbSNP
rs1173708625 115 dbSNP
rs1479263295 119 dbSNP
rs981137666 120 dbSNP
rs1440172751 125 dbSNP
rs886053089 127 dbSNP
rs1031354552 128 dbSNP
rs528416226 130 dbSNP
rs1425980133 134 dbSNP
rs182749804 138 dbSNP
rs1220889628 139 dbSNP
rs1353559762 141 dbSNP
rs1342706724 144 dbSNP
rs1301428456 152 dbSNP
rs377072500 153 dbSNP
rs568118228 153 dbSNP
rs574086508 153 dbSNP
rs946940722 153 dbSNP
rs537263986 163 dbSNP
rs1460207419 165 dbSNP
rs1335203187 170 dbSNP
rs1296756372 173 dbSNP
rs1379583727 175 dbSNP
rs1416657142 175 dbSNP
rs1393799847 177 dbSNP
rs1172534665 179 dbSNP
rs1439750480 185 dbSNP
rs368698021 185 dbSNP
rs1448113760 187 dbSNP
rs1381822672 191 dbSNP
rs1314990203 196 dbSNP
rs1381279654 202 dbSNP
rs1237845816 203 dbSNP
rs1211970306 207 dbSNP
rs923309941 219 dbSNP
rs986787580 224 dbSNP
rs1279495932 237 dbSNP
rs1363638316 247 dbSNP
rs1230068578 250 dbSNP
rs1210313903 258 dbSNP
rs1313615794 269 dbSNP
rs189009415 272 dbSNP
rs759257939 278 dbSNP
rs944673444 287 dbSNP
rs1040413962 288 dbSNP
rs1202708616 291 dbSNP
rs1259707649 297 dbSNP
rs1285222157 297 dbSNP
rs1450613042 298 dbSNP
rs1458065869 301 dbSNP
rs1202852158 307 dbSNP
rs887002889 312 dbSNP
rs897850524 318 dbSNP
rs1156235577 323 dbSNP
rs535357758 346 dbSNP
rs939883680 355 dbSNP
rs1032269668 371 dbSNP
rs765039169 373 dbSNP
rs1446446536 389 dbSNP
rs570960779 395 dbSNP
rs367621770 399 dbSNP
rs1471672720 403 dbSNP
rs1418185438 413 dbSNP
rs1426301712 427 dbSNP
rs1454621604 428 dbSNP
rs1172125796 430 dbSNP
rs1049207905 435 dbSNP
rs886053090 440 dbSNP
rs898313428 442 dbSNP
rs1001993576 443 dbSNP
rs1033420093 450 dbSNP
rs539834727 461 dbSNP
rs1230427101 475 dbSNP
rs1353987479 476 dbSNP
rs1013628976 478 dbSNP
rs1293009702 480 dbSNP
rs553453000 481 dbSNP
rs1450890551 487 dbSNP
rs1286673086 488 dbSNP
rs1452404658 494 dbSNP
rs1350151169 496 dbSNP
rs1166517849 499 dbSNP
rs1303440817 505 dbSNP
rs967334109 507 dbSNP
rs1023269720 509 dbSNP
rs192380904 518 dbSNP
rs1171044739 519 dbSNP
rs542501442 521 dbSNP
rs1259555834 530 dbSNP
rs1032493296 532 dbSNP
rs1485564367 553 dbSNP
rs886053091 553 dbSNP
rs1247325425 555 dbSNP
rs762300329 559 dbSNP
rs150855658 560 dbSNP
rs1273024948 564 dbSNP
rs923321079 567 dbSNP
rs1320681035 568 dbSNP
rs1294021508 571 dbSNP
rs1382120771 575 dbSNP
rs139239649 577 dbSNP
rs1222670439 581 dbSNP
rs1438270257 594 dbSNP
rs1261090079 606 dbSNP
rs1444013783 607 dbSNP
rs1210737657 614 dbSNP
rs1331852853 616 dbSNP
rs1021371162 617 dbSNP
rs1484618181 622 dbSNP
rs1187811196 624 dbSNP
rs1423851434 629 dbSNP
rs1433653189 635 dbSNP
rs968585498 639 dbSNP
rs17225109 640 dbSNP
rs1427654304 642 dbSNP
rs1459395190 648 dbSNP
rs1249930098 661 dbSNP
rs751958150 666 dbSNP
rs1335476213 668 dbSNP
rs16941864 672 dbSNP
rs1231419599 674 dbSNP
rs886053092 675 dbSNP
rs1369848908 678 dbSNP
rs1428690713 689 dbSNP
rs976359121 696 dbSNP
rs886053093 700 dbSNP
rs1448476748 702 dbSNP
rs1394094831 704 dbSNP
rs767868816 705 dbSNP
rs1038291776 713 dbSNP
rs2317676 714 dbSNP
rs1466491529 722 dbSNP
rs937793494 723 dbSNP
rs183374782 725 dbSNP
rs1175660127 728 dbSNP
rs1054882004 730 dbSNP
rs1452625092 736 dbSNP
rs756487158 740 dbSNP
rs770026180 757 dbSNP
rs886053094 759 dbSNP
rs1281071718 760 dbSNP
rs1195587537 761 dbSNP
rs558874269 768 dbSNP
rs1346902796 782 dbSNP
rs1283060291 787 dbSNP
rs1208150951 788 dbSNP
rs909307162 791 dbSNP
rs528081848 796 dbSNP
rs548149620 797 dbSNP
rs1241889694 800 dbSNP
rs1315096073 803 dbSNP
rs373163926 803 dbSNP
rs907054482 811 dbSNP
rs1263344485 816 dbSNP
rs1490067335 826 dbSNP
rs1002733792 831 dbSNP
rs1245303588 845 dbSNP
rs1479196956 849 dbSNP
rs1311027965 857 dbSNP
rs568363740 883 dbSNP
rs149984647 900 dbSNP
rs1173568542 904 dbSNP
rs1042473236 905 dbSNP
rs1159263627 909 dbSNP
rs550794564 910 dbSNP
rs570957269 914 dbSNP
rs73322319 920 dbSNP
rs1001109651 921 dbSNP
rs891461622 940 dbSNP
rs1259993685 943 dbSNP
rs1186445574 946 dbSNP
rs1032523973 964 dbSNP
rs569256631 972 dbSNP
rs1399528420 983 dbSNP
rs1160474657 998 dbSNP
rs1259751070 1001 dbSNP
rs1245015999 1004 dbSNP
rs996278003 1007 dbSNP
rs1361253919 1012 dbSNP
rs1414103076 1013 dbSNP
rs1424218607 1014 dbSNP
rs1021297630 1015 dbSNP
rs1333092388 1016 dbSNP
rs953836348 1016 dbSNP
rs3809865 1017 dbSNP
rs1158238637 1018 dbSNP
rs1278805228 1020 dbSNP
rs1017757549 1023 dbSNP
rs1242241109 1049 dbSNP
rs370968972 1051 dbSNP
rs954988470 1068 dbSNP
rs983538537 1073 dbSNP
rs868086291 1080 dbSNP
rs919511427 1086 dbSNP
rs963402553 1097 dbSNP
rs973993454 1103 dbSNP
rs1444812564 1115 dbSNP
rs1451893164 1128 dbSNP
rs919802020 1131 dbSNP
rs1210077657 1137 dbSNP
rs1336413833 1138 dbSNP
rs984802588 1145 dbSNP
rs1271116072 1153 dbSNP
rs909265491 1154 dbSNP
rs56288308 1155 dbSNP
rs1438313785 1166 dbSNP
rs1044904685 1169 dbSNP
rs41482350 1186 dbSNP
rs55912201 1199 dbSNP
rs1324781493 1201 dbSNP
rs1317653476 1206 dbSNP
rs555763985 1217 dbSNP
rs1380947796 1221 dbSNP
rs1396955723 1222 dbSNP
rs1424069808 1226 dbSNP
rs886053095 1226 dbSNP
rs1161573574 1242 dbSNP
rs1461229561 1259 dbSNP
rs1424740281 1263 dbSNP
rs1170173107 1264 dbSNP
rs575926243 1267 dbSNP
rs1372008795 1272 dbSNP
rs938558461 1273 dbSNP
rs1052930452 1280 dbSNP
rs1393138006 1281 dbSNP
rs1304385421 1286 dbSNP
rs1054935386 1287 dbSNP
rs1327871226 1291 dbSNP
rs779099404 1293 dbSNP
rs540838629 1294 dbSNP
rs1448851289 1304 dbSNP
rs1235095969 1312 dbSNP
rs1373528121 1318 dbSNP
rs1301565498 1319 dbSNP
rs1309911666 1322 dbSNP
rs142312068 1332 dbSNP
rs949178771 1335 dbSNP
rs1331218180 1346 dbSNP
rs144384270 1348 dbSNP
rs1408786793 1356 dbSNP
rs1396394844 1370 dbSNP
rs1042709069 1373 dbSNP
rs902188133 1383 dbSNP
rs1455173919 1388 dbSNP
rs114527845 1389 dbSNP
rs1356542706 1394 dbSNP
rs1439861461 1406 dbSNP
rs1053985374 1409 dbSNP
rs1202174761 1411 dbSNP
rs1437223404 1412 dbSNP
rs1006631347 1414 dbSNP
rs900736104 1415 dbSNP
rs1439632829 1416 dbSNP
rs1211735613 1430 dbSNP
rs1350174554 1443 dbSNP
rs1019820998 1450 dbSNP
rs901971447 1451 dbSNP
rs996372649 1452 dbSNP
rs367812163 1457 dbSNP
rs376311148 1462 dbSNP
rs1456736571 1471 dbSNP
rs954898154 1476 dbSNP
rs115310198 1480 dbSNP
rs1335731564 1498 dbSNP
rs1314050303 1504 dbSNP
rs541835356 1505 dbSNP
rs760779885 1506 dbSNP
rs1172398420 1507 dbSNP
rs1420002092 1522 dbSNP
rs1409688061 1525 dbSNP
rs561828022 1528 dbSNP
rs1469409717 1540 dbSNP
rs1237789813 1541 dbSNP
rs73322321 1543 dbSNP
rs1026914544 1544 dbSNP
rs1484612872 1561 dbSNP
rs1185489221 1562 dbSNP
rs959302703 1571 dbSNP
rs985065342 1573 dbSNP
rs1286577126 1577 dbSNP
rs990732123 1579 dbSNP
rs1222241301 1581 dbSNP
rs1016253517 1583 dbSNP
rs1294223838 1584 dbSNP
rs917780047 1586 dbSNP
rs1370281173 1587 dbSNP
rs1473209732 1589 dbSNP
rs1167586788 1590 dbSNP
rs1311807079 1593 dbSNP
rs550606683 1594 dbSNP
rs980210064 1595 dbSNP
rs1156532791 1602 dbSNP
rs928715958 1604 dbSNP
rs1466970214 1613 dbSNP
rs938486800 1622 dbSNP
rs978249300 1624 dbSNP
rs1166823185 1640 dbSNP
rs1474219343 1642 dbSNP
rs1256694916 1647 dbSNP
rs770967790 1653 dbSNP
rs1405249199 1657 dbSNP
rs1450375383 1660 dbSNP
rs923691869 1664 dbSNP
rs1335544775 1666 dbSNP
rs1213922225 1667 dbSNP
rs1340585699 1672 dbSNP
rs936355652 1682 dbSNP
rs564235473 1683 dbSNP
rs1274268696 1699 dbSNP
rs1235509061 1713 dbSNP
rs187420016 1715 dbSNP
rs1293180389 1728 dbSNP
rs1215627060 1734 dbSNP
rs1363470973 1735 dbSNP
rs1268026691 1750 dbSNP
rs1319602452 1751 dbSNP
rs1220840102 1753 dbSNP
rs1043398738 1757 dbSNP
rs1259172898 1759 dbSNP
rs889455128 1769 dbSNP
rs900160291 1771 dbSNP
rs942362292 1772 dbSNP
rs1040764612 1774 dbSNP
rs1459650088 1774 dbSNP
rs1171090575 1787 dbSNP
rs1258299202 1798 dbSNP
rs932276529 1799 dbSNP
rs886053096 1805 dbSNP
rs776553854 1818 dbSNP
rs890627391 1822 dbSNP
rs1253841064 1823 dbSNP
rs1005012070 1832 dbSNP
rs1215984392 1841 dbSNP
rs1026466292 1848 dbSNP
rs1015440368 1852 dbSNP
rs1272892762 1855 dbSNP
rs899218525 1861 dbSNP
rs868329279 1863 dbSNP
rs886636090 1869 dbSNP
rs1309778108 1882 dbSNP
rs1292898223 1885 dbSNP
rs745599243 1887 dbSNP
rs1371334497 1910 dbSNP
rs1305223656 1913 dbSNP
rs377459949 1915 dbSNP
rs970046879 1916 dbSNP
rs769714691 1918 dbSNP
rs1463519954 1923 dbSNP
rs1352673989 1924 dbSNP
rs1168485040 1932 dbSNP
rs886053097 1933 dbSNP
rs1035751500 1934 dbSNP
rs547089269 1935 dbSNP
rs1452740460 1942 dbSNP
rs1267185146 1943 dbSNP
rs1178130045 1945 dbSNP
rs1481936411 1949 dbSNP
rs1250097354 1954 dbSNP
rs192215916 1960 dbSNP
rs762687226 1961 dbSNP
rs147832328 1971 dbSNP
rs1174271279 1977 dbSNP
rs763486656 1979 dbSNP
rs1231625689 1981 dbSNP
rs947260652 1984 dbSNP
rs148880380 1986 dbSNP
rs1392893602 1990 dbSNP
rs569446308 1992 dbSNP
rs1376156436 2000 dbSNP
rs942351235 2000 dbSNP
rs1175596232 2017 dbSNP
rs1295877536 2018 dbSNP
rs1433158691 2022 dbSNP
rs542150449 2023 dbSNP
rs1377262929 2027 dbSNP
rs886053098 2031 dbSNP
rs143482198 2035 dbSNP
rs923763539 2037 dbSNP
rs1248804188 2047 dbSNP
rs558036152 2049 dbSNP
rs1279161399 2053 dbSNP
rs936448969 2055 dbSNP
rs371411493 2060 dbSNP
rs921637366 2071 dbSNP
rs577778439 2082 dbSNP
rs1046881991 2084 dbSNP
rs886604960 2085 dbSNP
rs1204618876 2087 dbSNP
rs1052449395 2088 dbSNP
rs1006805034 2096 dbSNP
rs1037924923 2107 dbSNP
rs534143307 2118 dbSNP
rs1001522712 2140 dbSNP
rs79966028 2144 dbSNP
rs1035639440 2149 dbSNP
rs940867268 2160 dbSNP
rs1036560490 2168 dbSNP
rs1267860285 2176 dbSNP
rs552626443 2178 dbSNP
rs899311692 2181 dbSNP
rs1010271908 2183 dbSNP
rs1455491802 2184 dbSNP
rs994959847 2187 dbSNP
rs1431212731 2188 dbSNP
rs1158879340 2199 dbSNP
rs1020327366 2204 dbSNP
rs1034423401 2206 dbSNP
rs1420618876 2207 dbSNP
rs1185207212 2212 dbSNP
rs1200790105 2213 dbSNP
rs1378126432 2214 dbSNP
rs572644422 2216 dbSNP
rs1156239122 2222 dbSNP
rs894485082 2223 dbSNP
rs148008191 2225 dbSNP
rs1361901147 2227 dbSNP
rs1206541545 2228 dbSNP
rs561681430 2235 dbSNP
rs1267334594 2241 dbSNP
rs1233654532 2242 dbSNP
rs1302170666 2246 dbSNP
rs1025326503 2247 dbSNP
rs1291399916 2264 dbSNP
rs1365109057 2270 dbSNP
rs575144027 2273 dbSNP
rs970700876 2279 dbSNP
rs964286366 2284 dbSNP
rs1385422535 2286 dbSNP
rs1383050347 2291 dbSNP
rs999831726 2294 dbSNP
rs1303940913 2299 dbSNP
rs1462261926 2302 dbSNP
rs1397086744 2310 dbSNP
rs544462074 2313 dbSNP
rs1240066243 2316 dbSNP
rs1030833217 2321 dbSNP
rs58365772 2328 dbSNP
rs1256692904 2331 dbSNP
rs1046808623 2335 dbSNP
rs1246997611 2348 dbSNP
rs989198167 2350 dbSNP
rs909641575 2354 dbSNP
rs1355977782 2357 dbSNP
rs921646807 2358 dbSNP
rs367660650 2364 dbSNP
rs1217504156 2380 dbSNP
rs1291282622 2382 dbSNP
rs1270978194 2387 dbSNP
rs1209174863 2391 dbSNP
rs750936469 2404 dbSNP
rs942185427 2409 dbSNP
rs1270902597 2413 dbSNP
rs1229670440 2417 dbSNP
rs1363334163 2418 dbSNP
rs868210216 2419 dbSNP
rs1192689732 2423 dbSNP
rs533139765 2427 dbSNP
rs906057430 2436 dbSNP
rs1405363934 2444 dbSNP
rs1397808580 2452 dbSNP
rs73322322 2456 dbSNP
rs1460054572 2492 dbSNP
rs1388963058 2494 dbSNP
rs766754405 2504 dbSNP
rs1455255691 2505 dbSNP
rs560559052 2506 dbSNP
rs1162419187 2510 dbSNP
rs1036612440 2512 dbSNP
rs1347751807 2516 dbSNP
rs895780156 2517 dbSNP
rs1459133466 2520 dbSNP
rs1340160566 2523 dbSNP
rs920794806 2526 dbSNP
rs1295586335 2530 dbSNP
rs1273939485 2543 dbSNP
rs930762321 2548 dbSNP
rs1055909214 2556 dbSNP
rs184806329 2567 dbSNP
rs755268423 2572 dbSNP
rs549212649 2581 dbSNP
rs569191870 2582 dbSNP
rs1331484677 2583 dbSNP
rs1408472812 2584 dbSNP
rs1369402234 2585 dbSNP
rs1173708124 2587 dbSNP
rs969225416 2592 dbSNP
rs1000308608 2593 dbSNP
rs999483237 2599 dbSNP
rs539806535 2620 dbSNP
rs1179593016 2634 dbSNP
rs1482650559 2645 dbSNP
rs1379818842 2651 dbSNP
rs1251262162 2663 dbSNP
rs537865257 2676 dbSNP
rs551627135 2685 dbSNP
rs1350374577 2686 dbSNP
rs963946064 2687 dbSNP
rs1240965034 2691 dbSNP
rs1030843134 2694 dbSNP
rs72120955 2698 dbSNP
rs957868608 2698 dbSNP
rs1010671036 2700 dbSNP
rs1028711219 2702 dbSNP
rs1333125406 2710 dbSNP
rs1400871028 2711 dbSNP
rs950995394 2712 dbSNP
rs1320078909 2717 dbSNP
rs982459057 2723 dbSNP
rs1224050192 2725 dbSNP
rs953184130 2744 dbSNP
rs1189927909 2751 dbSNP
rs1486707071 2759 dbSNP
rs1235747740 2761 dbSNP
rs1209685490 2768 dbSNP
rs941091180 2771 dbSNP
rs1044851954 2772 dbSNP
rs1226914079 2772 dbSNP
rs1329126336 2773 dbSNP
rs189780895 2782 dbSNP
rs911599380 2783 dbSNP
rs1196577745 2784 dbSNP
rs1376363675 2785 dbSNP
rs1283024108 2798 dbSNP
rs1431099406 2806 dbSNP
rs1346584527 2811 dbSNP
rs1318351621 2818 dbSNP
rs1239900297 2825 dbSNP
rs1456536209 2831 dbSNP
rs1394883686 2833 dbSNP
rs1167025761 2840 dbSNP
rs1421912240 2842 dbSNP
rs372193713 2847 dbSNP
rs1181336758 2852 dbSNP
rs1475890571 2856 dbSNP
rs1244025757 2862 dbSNP
rs534109481 2864 dbSNP
rs192694218 2866 dbSNP
rs1057309330 2875 dbSNP
rs140661797 2880 dbSNP
rs1216104839 2885 dbSNP
rs946033474 2894 dbSNP
rs930814486 2896 dbSNP
rs1056005128 2898 dbSNP
rs916047743 2902 dbSNP
rs9916007 2903 dbSNP
rs1000654242 2904 dbSNP
rs1018361910 2909 dbSNP
rs899660989 2910 dbSNP
rs866505961 2919 dbSNP
rs1456379583 2920 dbSNP
rs998051675 2924 dbSNP
rs1403075469 2928 dbSNP
rs1046225726 2929 dbSNP
rs555188719 2931 dbSNP
rs1302268225 2932 dbSNP
rs1377107609 2937 dbSNP
rs1487820556 2955 dbSNP
rs368441527 2959 dbSNP
rs951299128 2959 dbSNP
rs1230189189 2960 dbSNP
rs998773286 2962 dbSNP
rs982712396 2963 dbSNP
rs1271775395 2966 dbSNP
rs1317557943 2966 dbSNP
rs1052320934 2967 dbSNP
rs575150689 2968 dbSNP
rs543896870 2969 dbSNP
rs1216562904 2970 dbSNP
rs558069990 2970 dbSNP
rs1366590127 2972 dbSNP
rs1296160392 2978 dbSNP
rs1016980428 2985 dbSNP
rs962409964 2986 dbSNP
rs1259817628 2990 dbSNP
rs1429418374 2991 dbSNP
rs8068200 2993 dbSNP
rs35863043 3005 dbSNP
rs781207607 3006 dbSNP
rs1267041320 3008 dbSNP
rs1235192717 3009 dbSNP
rs1028805990 3022 dbSNP
rs888942424 3023 dbSNP
rs1203779884 3028 dbSNP
rs1181981070 3033 dbSNP
rs1348198356 3039 dbSNP
rs1282055572 3042 dbSNP
rs184143910 3046 dbSNP
rs1008678883 3048 dbSNP
rs1311408696 3059 dbSNP
rs745829993 3066 dbSNP
rs937498831 3066 dbSNP
rs778229560 3067 dbSNP
rs745408451 3070 dbSNP
rs1409251801 3079 dbSNP
rs1376104243 3098 dbSNP
rs1476671045 3099 dbSNP
rs992982009 3102 dbSNP
rs1377486100 3105 dbSNP
rs1426234067 3106 dbSNP
rs112556373 3108 dbSNP
rs1410354246 3111 dbSNP
rs531351645 3119 dbSNP
rs1485723913 3120 dbSNP
rs971697308 3122 dbSNP
rs1257592487 3126 dbSNP
rs1357975689 3132 dbSNP
rs1450257543 3135 dbSNP
rs899425780 3139 dbSNP
rs1210338750 3140 dbSNP
rs1327046785 3141 dbSNP
rs1233760759 3142 dbSNP
rs946274209 3142 dbSNP
rs11381846 3144 dbSNP
rs1401738037 3144 dbSNP
rs201185307 3144 dbSNP
rs397963836 3144 dbSNP
rs1289857488 3145 dbSNP
rs1340107063 3146 dbSNP
rs1159096750 3148 dbSNP
rs529086024 3148 dbSNP
rs904483473 3149 dbSNP
rs1369765139 3161 dbSNP
rs1348533972 3162 dbSNP
rs1279815072 3164 dbSNP
rs1422930910 3178 dbSNP
rs1318363745 3180 dbSNP
rs936054734 3190 dbSNP
rs1463396418 3197 dbSNP
rs143090841 3204 dbSNP
rs1214319548 3207 dbSNP
rs1267352982 3213 dbSNP
rs562861133 3215 dbSNP
rs1276383615 3218 dbSNP
rs1339904130 3223 dbSNP
rs146118223 3228 dbSNP
rs1210195446 3229 dbSNP
rs138874256 3236 dbSNP
rs1462483672 3237 dbSNP
rs1029476413 3239 dbSNP
rs952298602 3244 dbSNP
rs112549377 3245 dbSNP
rs1004096548 3253 dbSNP
rs1190115032 3261 dbSNP
rs916115937 3268 dbSNP
rs113252032 3269 dbSNP
rs1478341654 3273 dbSNP
rs981551970 3288 dbSNP
rs1423681979 3289 dbSNP
rs1209111420 3290 dbSNP
rs547696129 3298 dbSNP
rs1416709274 3301 dbSNP
rs9894860 3304 dbSNP
rs536468555 3305 dbSNP
rs1033829738 3313 dbSNP
rs1054414123 3319 dbSNP
rs555420024 3322 dbSNP
rs893120182 3327 dbSNP
rs1360015966 3334 dbSNP
rs186343400 3336 dbSNP
rs1300248654 3337 dbSNP
rs1427477620 3338 dbSNP
rs1341403348 3346 dbSNP
rs188886946 3347 dbSNP
rs1478898275 3367 dbSNP
rs557832542 3368 dbSNP
rs1198080568 3371 dbSNP
rs1369563433 3379 dbSNP
rs946221512 3381 dbSNP
rs12600603 3382 dbSNP
rs1009104969 3389 dbSNP
rs1018712151 3392 dbSNP
rs540492615 3393 dbSNP
rs1219986082 3397 dbSNP
rs1218228493 3398 dbSNP
rs1347598077 3426 dbSNP
rs1039729901 3440 dbSNP
rs993229571 3442 dbSNP
rs9893410 3446 dbSNP
rs558309179 3453 dbSNP
rs991749078 3454 dbSNP
rs573749502 3457 dbSNP
rs1051186544 3459 dbSNP
rs1221279634 3468 dbSNP
rs1334414581 3479 dbSNP
rs1023600107 3482 dbSNP
rs761322769 3495 dbSNP
rs1422887584 3499 dbSNP
rs1479267135 3501 dbSNP
rs1171770732 3502 dbSNP
rs886941370 3523 dbSNP
rs1414057165 3538 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084042. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep2 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgGU-CGAUUGUUAUGUGACGGa 5'
            || ||  :::|  ||||||| 
Target 5' uaCAGGC--GUGAGCCACUGCC- 3'
 		17 - 36
2 
miRNA  3' cggucgauuGUUAUGUGACgga 5'
                   ||| :::|||   
Target 5' -------ccCAAAGUGCUGgga 3'
 		1 - 15
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084042
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep2
Location of target site ENST00000559488.1 | 3UTR | CCCAAAGUGCUGGGAUUACAGGCGUGAGCCACUGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.525 8.7e-3 -0.838 2.0e-6 20 Click to see details
GSE28260 Renal cortex and medulla -0.574 2.0e-2 -0.544 2.7e-2 13 Click to see details
GSE42095 Differentiated embryonic stem cells 0.34 5.6e-2 0.533 4.4e-3 23 Click to see details
GSE38226 Liver fibrosis 0.346 6.2e-2 0.111 3.2e-1 21 Click to see details
GSE17306 Multiple myeloma 0.169 1.2e-1 0.243 4.6e-2 49 Click to see details
GSE19783 ER- ER- breast cancer 0.111 1.7e-1 -0.028 4.0e-1 79 Click to see details
GSE32688 Pancreatic cancer -0.177 1.7e-1 -0.065 3.6e-1 32 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.189 1.8e-1 0.266 9.9e-2 25 Click to see details
GSE17498 Multiple myeloma -0.133 2.1e-1 -0.232 7.5e-2 40 Click to see details
GSE26953 Aortic valvular endothelial cells 0.17 2.1e-1 0.208 1.6e-1 24 Click to see details
GSE14794 Lymphoblastoid cells 0.082 2.2e-1 0.060 2.9e-1 90 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.317 2.2e-1 0.738 1.8e-2 8 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.16 2.2e-1 -0.065 3.8e-1 25 Click to see details
GSE19350 CNS germ cell tumors 0.243 2.2e-1 0.182 2.9e-1 12 Click to see details
GSE28544 Breast cancer -0.161 2.3e-1 -0.020 4.6e-1 24 Click to see details
GSE19783 ER+ ER+ breast cancer -0.136 2.8e-1 -0.215 1.8e-1 20 Click to see details
GSE21687 Ependynoma primary tumors -0.068 3.0e-1 -0.014 4.6e-1 64 Click to see details
GSE19536 Breast cancer 0.013 4.5e-1 -0.038 3.5e-1 100 Click to see details
GSE27834 Pluripotent stem cells 0.019 4.7e-1 -0.168 2.7e-1 16 Click to see details
GSE21849 B cell lymphoma -0.012 4.8e-1 0.295 6.0e-2 29 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA -0.985 0.06 -0.500 0.33 3 Click to see details
LUSC -0.615 0.19 -0.800 0.1 4 Click to see details
BRCA -0.492 0.25 -0.400 0.3 4 Click to see details
UCEC 0.144 0.37 0.167 0.35 8 Click to see details
UCEC 0.144 0.37 0.167 0.35 8 Click to see details
UCEC 0.144 0.37 0.167 0.35 8 Click to see details
UCEC 0.144 0.37 0.167 0.35 8 Click to see details
UCEC 0.144 0.37 0.167 0.35 8 Click to see details
109 hsa-miR-449b-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006349 SIRT1 sirtuin 1 2 1
MIRT006350 CCNE2 cyclin E2 4 3
MIRT006351 MET MET proto-oncogene, receptor tyrosine kinase 2 1
MIRT006352 GMNN geminin, DNA replication inhibitor 2 1
MIRT006353 HDAC1 histone deacetylase 1 2 1
MIRT016137 CDK4 cyclin dependent kinase 4 1 1
MIRT016138 CDC25A cell division cycle 25A 2 1
MIRT016139 CDK6 cyclin dependent kinase 6 4 3
MIRT057740 ZDHHC16 zinc finger DHHC-type containing 16 2 2
MIRT078636 FAM104A family with sequence similarity 104 member A 2 2
MIRT100407 HSPA1B heat shock protein family A (Hsp70) member 1B 2 2
MIRT115552 MAZ MYC associated zinc finger protein 2 2
MIRT130146 TXNIP thioredoxin interacting protein 2 4
MIRT142254 DCTN5 dynactin subunit 5 2 2
MIRT143724 CCL22 C-C motif chemokine ligand 22 2 2
MIRT168101 E2F3 E2F transcription factor 3 2 2
MIRT169809 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT183694 MDM4 MDM4, p53 regulator 2 2
MIRT198922 SMAD4 SMAD family member 4 2 2
MIRT202950 TSN translin 2 4
MIRT221565 CBX3 chromobox 3 2 2
MIRT253418 EVI5L ecotropic viral integration site 5 like 2 2
MIRT294759 ZNF551 zinc finger protein 551 2 4
MIRT307053 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT331273 TM9SF3 transmembrane 9 superfamily member 3 2 6
MIRT372293 UBXN2B UBX domain protein 2B 2 2
MIRT374317 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT445817 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT447158 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT447823 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT448798 GMFB glia maturation factor beta 2 2
MIRT451580 HIRIP3 HIRA interacting protein 3 2 2
MIRT452679 GPR156 G protein-coupled receptor 156 2 2
MIRT453158 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT453634 SLC4A2 solute carrier family 4 member 2 2 2
MIRT455384 PLA2G2D phospholipase A2 group IID 2 2
MIRT456958 SPAM1 sperm adhesion molecule 1 2 2
MIRT462739 EFNB1 ephrin B1 2 2
MIRT464321 UST uronyl 2-sulfotransferase 2 2
MIRT465641 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 10
MIRT466748 SYNGR2 synaptogyrin 2 2 2
MIRT468345 SF3B3 splicing factor 3b subunit 3 2 2
MIRT469324 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT474361 KMT2D lysine methyltransferase 2D 2 2
MIRT475316 IFNLR1 interferon lambda receptor 1 2 2
MIRT477759 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT477824 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478265 DDX19B DEAD-box helicase 19B 2 2
MIRT481042 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT481289 ATXN1L ataxin 1 like 2 2
MIRT482730 COPZ1 coatomer protein complex subunit zeta 1 2 2
MIRT488780 CYTH3 cytohesin 3 2 2
MIRT489578 SSBP2 single stranded DNA binding protein 2 2 2
MIRT489659 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT490527 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT492949 NEUROD2 neuronal differentiation 2 2 2
MIRT493154 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT493845 FOXN3 forkhead box N3 2 4
MIRT494743 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT496491 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT503312 FICD FIC domain containing 2 4
MIRT503507 ZNF623 zinc finger protein 623 2 2
MIRT504182 FAM127B retrotransposon Gag like 8A 2 2
MIRT505010 ZNF644 zinc finger protein 644 2 2
MIRT505352 TMEM167A transmembrane protein 167A 2 2
MIRT505645 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT505710 SESN2 sestrin 2 2 2
MIRT505777 SATB2 SATB homeobox 2 2 6
MIRT506208 PHF19 PHD finger protein 19 2 2
MIRT506251 PEG10 paternally expressed 10 2 2
MIRT507786 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT508005 BCL2L13 BCL2 like 13 2 4
MIRT508857 ZRSR1 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1 2 4
MIRT510546 XBP1P1 X-box binding protein 1 pseudogene 1 2 4
MIRT511892 GAS1 growth arrest specific 1 2 6
MIRT512907 UBL4A ubiquitin like 4A 2 2
MIRT513600 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT521241 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT521321 RRAGD Ras related GTP binding D 2 4
MIRT525281 C18orf32 chromosome 18 open reading frame 32 2 2
MIRT528650 RWDD2A RWD domain containing 2A 2 4
MIRT535101 PODXL podocalyxin like 2 2
MIRT547752 KBTBD6 kelch repeat and BTB domain containing 6 2 4
MIRT547865 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT549170 BMP3 bone morphogenetic protein 3 2 2
MIRT550115 SLC35G2 solute carrier family 35 member G2 2 2
MIRT556097 MOAP1 modulator of apoptosis 1 2 2
MIRT557172 HOXA13 homeobox A13 2 2
MIRT557422 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT557931 FAM73A mitoguardin 1 2 2
MIRT568804 VPS37D VPS37D, ESCRT-I subunit 2 2
MIRT571326 TPCN2 two pore segment channel 2 2 2
MIRT572598 PAPLN papilin, proteoglycan like sulfated glycoprotein 2 2
MIRT573437 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT574092 VASN vasorin 2 2
MIRT608688 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT608800 ITGA11 integrin subunit alpha 11 2 4
MIRT610332 SSX5 SSX family member 5 2 2
MIRT613158 DDA1 DET1 and DDB1 associated 1 2 2
MIRT625407 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 2
MIRT636603 CLIC5 chloride intracellular channel 5 2 2
MIRT638573 IER5 immediate early response 5 2 2
MIRT639686 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT677979 ITGB3 integrin subunit beta 3 2 2
MIRT685217 POTED POTE ankyrin domain family member D 2 2
MIRT702570 JARID2 jumonji and AT-rich interaction domain containing 2 2 2
MIRT706259 MKLN1 muskelin 1 2 2
MIRT734675 HMGB1 high mobility group box 1 3 0
MIRT736369 HSPA1A heat shock protein family A (Hsp70) member 1A 1 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-449b Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-449b Doxorubicin approved 31703 Quantitative real-time PCR ovarian carcinoma cell line A2780 cells 22340095 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SUIT-2, CAPAN-1)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Panobinostat 6918837 NSC761190 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-449b-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (HeyA8)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-449b-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

Error report submission