pre-miRNA Information
pre-miRNA hsa-mir-1245a   
Genomic Coordinates chr2: 188978092 - 188978161
Description Homo sapiens miR-1245a stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1245a
Sequence 45| AAGUGAUCUAAAGGCCUACAU |65
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31562560 15 COSMIC
COSN26581044 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs906938680 2 dbSNP
rs1159117523 3 dbSNP
rs780486044 6 dbSNP
rs771479866 17 dbSNP
rs1002976932 18 dbSNP
rs1428029219 19 dbSNP
Putative Targets

Gene Information
Gene Symbol SRCAP   
Synonyms DOMO1, EAF1, FLHS, SWR1
Description Snf2 related CREBBP activator protein
Transcript NM_006662   
Expression
Putative miRNA Targets on SRCAP
3'UTR of SRCAP
(miRNA target sites are highlighted)
>SRCAP|NM_006662|3'UTR
   1 GTGGGCTGCCCCTCCACCTAGGCTTTCCACCGTGGCCACTCCCTCCATGACCAGGCCTGACTCTGTTAACCACTACTTGA
  81 AGTCTTGAGGGGGAAAGCCTCCAGGGAGACATAGGGGCCTTCTCCCTTCTTCCCACCAAAGTAGGGGGTAGGCAACTGGT
 161 TGTCATGGAAATGGGGATCATCACAGTCCCCTTCCCCTTCACCCCACGTGGCTGGGCAGTGTTAAGGGTGGCAAGATAGT
 241 CTCTGTCCCCACCCCCTTGTACTTGATTCCCCAGCTGTCTTTCACACAGCCCCCCACCCTTAGGGGAAGGGGGAGGGGCT
 321 TCTCTACAATGAGGTTTTTTTCTTTTTTTTTTTTTTTTAAGAAGAAAAAATAATAAACTTAGTTTCTGTATGAGCAAAAA
 401 AAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uacAUCCGGAA-AU----CUAGUGAa 5'
             |||||:||  |    |: |||| 
Target 5' accTAGGCTTTCCACCGTGGCCACTc 3'
16 - 41 108.00 -10.20
2
miRNA  3' uacAUCCGGAAAUCUAGUGaa 5'
             |:|   |  :|||||:  
Target 5' tcaTGGAAATGGGGATCATca 3'
163 - 183 106.00 -7.00
3
miRNA  3' uacaUCCGGA-----A-AUCUAGUGAa 5'
              ||||||     | |  | |||| 
Target 5' gaccAGGCCTGACTCTGTTAACCACTa 3'
49 - 75 89.00 -8.97
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
318924 244 ClinVar
318925 342 ClinVar
318926 343 ClinVar
COSN30096746 118 COSMIC
COSN31492407 175 COSMIC
COSN8497637 299 COSMIC
COSN17037408 332 COSMIC
COSN28087724 350 COSMIC
COSN31533057 351 COSMIC
COSN30538549 360 COSMIC
COSN31489109 362 COSMIC
COSN15157296 742 COSMIC
COSN9645498 834 COSMIC
COSN15848948 972 COSMIC
COSN17819902 1356 COSMIC
COSN5406409 1443 COSMIC
COSN5406410 1466 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs776557423 2 dbSNP
rs920827090 7 dbSNP
rs929481204 10 dbSNP
rs1181472367 11 dbSNP
rs1047899710 12 dbSNP
rs761359958 13 dbSNP
rs1421787558 15 dbSNP
rs764991569 16 dbSNP
rs376319548 23 dbSNP
rs1263045695 24 dbSNP
rs1451790192 30 dbSNP
rs763403768 32 dbSNP
rs142064048 33 dbSNP
rs990098300 36 dbSNP
rs1039127322 37 dbSNP
rs1220379641 38 dbSNP
rs368747756 39 dbSNP
rs1430339222 40 dbSNP
rs764402414 44 dbSNP
rs192066047 48 dbSNP
rs977267255 49 dbSNP
rs1403890918 50 dbSNP
rs1054394963 52 dbSNP
rs891678537 55 dbSNP
rs1010032406 57 dbSNP
rs1185651516 58 dbSNP
rs572979591 61 dbSNP
rs991137929 62 dbSNP
rs1185408688 64 dbSNP
rs1024051979 71 dbSNP
rs1478163895 73 dbSNP
rs971200508 80 dbSNP
rs1219113443 83 dbSNP
rs147764660 84 dbSNP
rs1034502093 89 dbSNP
rs1367429040 92 dbSNP
rs1315963175 93 dbSNP
rs1256266768 97 dbSNP
rs1461474763 103 dbSNP
rs1276775042 111 dbSNP
rs931563363 123 dbSNP
rs1166677030 125 dbSNP
rs1332420642 126 dbSNP
rs1467684677 126 dbSNP
rs1048650217 127 dbSNP
rs908702653 130 dbSNP
rs1414474911 139 dbSNP
rs1289883441 147 dbSNP
rs867682530 148 dbSNP
rs1041214888 151 dbSNP
rs901216188 154 dbSNP
rs997346786 162 dbSNP
rs1360492686 165 dbSNP
rs962429511 180 dbSNP
rs546713293 183 dbSNP
rs920872056 184 dbSNP
rs1180223095 194 dbSNP
rs1312595661 196 dbSNP
rs950913857 201 dbSNP
rs1257274216 204 dbSNP
rs1203933634 207 dbSNP
rs983623495 209 dbSNP
rs1280818929 210 dbSNP
rs1217728502 219 dbSNP
rs912104979 237 dbSNP
rs1235153595 238 dbSNP
rs1310475676 240 dbSNP
rs577624873 244 dbSNP
rs1011489319 245 dbSNP
rs1298046581 252 dbSNP
rs544993543 253 dbSNP
rs1360430515 259 dbSNP
rs1328825607 270 dbSNP
rs1380492403 275 dbSNP
rs1039141034 283 dbSNP
rs921985739 287 dbSNP
rs936026831 288 dbSNP
rs1054830183 290 dbSNP
rs1486708879 290 dbSNP
rs891713447 293 dbSNP
rs1003588420 297 dbSNP
rs562943440 299 dbSNP
rs998651359 300 dbSNP
rs1198695191 303 dbSNP
rs1286925826 307 dbSNP
rs1035941832 311 dbSNP
rs1010147301 327 dbSNP
rs1256663227 328 dbSNP
rs1306701526 329 dbSNP
rs1229446333 335 dbSNP
rs1475254932 335 dbSNP
rs1300601189 338 dbSNP
rs530755836 339 dbSNP
rs1360786556 341 dbSNP
rs1409118873 342 dbSNP
rs886051909 342 dbSNP
rs1035511782 343 dbSNP
rs1185902855 343 dbSNP
rs1221287930 343 dbSNP
rs1411482285 343 dbSNP
rs1417475585 343 dbSNP
rs1474887554 343 dbSNP
rs397854666 343 dbSNP
rs1472091329 344 dbSNP
rs991687911 347 dbSNP
rs1485004190 348 dbSNP
rs1159350934 351 dbSNP
rs1260528421 352 dbSNP
rs1365953253 353 dbSNP
rs915561349 356 dbSNP
rs1233199795 359 dbSNP
rs1279502351 359 dbSNP
rs1291918525 359 dbSNP
rs1340670699 359 dbSNP
rs1397800780 360 dbSNP
rs1383730204 379 dbSNP
rs1293923284 381 dbSNP
rs1464821035 387 dbSNP
rs907075225 400 dbSNP
rs1001305949 402 dbSNP
rs1164195403 409 dbSNP
rs1478103703 411 dbSNP
rs1424486075 415 dbSNP
rs983763438 416 dbSNP
rs1426995091 423 dbSNP
rs1261221121 428 dbSNP
rs1034121687 435 dbSNP
rs1302797507 435 dbSNP
rs962749711 439 dbSNP
rs1489707479 448 dbSNP
rs995192843 450 dbSNP
rs1213660495 452 dbSNP
rs756527660 453 dbSNP
rs1224556978 456 dbSNP
rs951026057 459 dbSNP
rs781512302 460 dbSNP
rs780533954 465 dbSNP
rs1301465381 467 dbSNP
rs1388137197 473 dbSNP
rs1365308834 475 dbSNP
rs1324948789 478 dbSNP
rs1466099528 479 dbSNP
rs1306323833 480 dbSNP
rs940278442 481 dbSNP
rs1349926436 487 dbSNP
rs548851878 492 dbSNP
rs1224585291 495 dbSNP
rs983731699 496 dbSNP
rs912127807 497 dbSNP
rs1177147912 507 dbSNP
rs1041182499 520 dbSNP
rs1251572879 534 dbSNP
rs1193338924 536 dbSNP
rs1458627308 536 dbSNP
rs1240494710 537 dbSNP
rs922793934 538 dbSNP
rs141458112 542 dbSNP
rs932747376 547 dbSNP
rs975284786 548 dbSNP
rs147006778 553 dbSNP
rs893911110 557 dbSNP
rs750439577 559 dbSNP
rs1279524141 560 dbSNP
rs1326843690 562 dbSNP
rs1485994219 563 dbSNP
rs1395916011 566 dbSNP
rs1010889927 570 dbSNP
rs1467792074 571 dbSNP
rs936043967 576 dbSNP
rs1347394128 583 dbSNP
rs770233425 585 dbSNP
rs1393455237 589 dbSNP
rs1042417836 590 dbSNP
rs1173407041 592 dbSNP
rs1249045313 607 dbSNP
rs903069658 612 dbSNP
rs1177456162 614 dbSNP
rs546440500 615 dbSNP
rs1431815446 616 dbSNP
rs1256271791 627 dbSNP
rs990247754 628 dbSNP
rs1201633355 631 dbSNP
rs913268128 634 dbSNP
rs183818756 639 dbSNP
rs756202931 640 dbSNP
rs138139662 641 dbSNP
rs1437178820 642 dbSNP
rs1277528136 643 dbSNP
rs1238307040 650 dbSNP
rs1340936328 651 dbSNP
rs960169506 652 dbSNP
rs1012656442 653 dbSNP
rs1312560397 659 dbSNP
rs1288458785 660 dbSNP
rs1362886538 673 dbSNP
rs1157169442 679 dbSNP
rs1370067531 680 dbSNP
rs937203554 681 dbSNP
rs1442964937 682 dbSNP
rs1488627297 691 dbSNP
rs1023107831 705 dbSNP
rs1189035263 710 dbSNP
rs952482124 711 dbSNP
rs1256193332 719 dbSNP
rs1489055832 722 dbSNP
rs1056002598 729 dbSNP
rs983712363 732 dbSNP
rs1015220200 735 dbSNP
rs898250234 738 dbSNP
rs1215166747 741 dbSNP
rs79825013 742 dbSNP
rs1204283250 743 dbSNP
rs1300132702 746 dbSNP
rs1356963864 749 dbSNP
rs995704201 765 dbSNP
rs1386417177 767 dbSNP
rs749291849 768 dbSNP
rs768222606 772 dbSNP
rs1353715156 773 dbSNP
rs922774033 775 dbSNP
rs754993208 776 dbSNP
rs985667060 776 dbSNP
rs915292376 785 dbSNP
rs946792538 786 dbSNP
rs1391891878 806 dbSNP
rs1167826689 807 dbSNP
rs551039985 809 dbSNP
rs1302479388 814 dbSNP
rs1348294146 815 dbSNP
rs886796177 817 dbSNP
rs1416593123 818 dbSNP
rs1007871939 820 dbSNP
rs1272335818 825 dbSNP
rs1239934374 833 dbSNP
rs1306437454 837 dbSNP
rs754772444 846 dbSNP
rs1291754281 849 dbSNP
rs778522390 858 dbSNP
rs1234112742 859 dbSNP
rs966248475 860 dbSNP
rs140828389 865 dbSNP
rs1364367604 866 dbSNP
rs1268701768 867 dbSNP
rs1029614645 870 dbSNP
rs1332083788 872 dbSNP
rs957552420 877 dbSNP
rs771555845 882 dbSNP
rs558365012 890 dbSNP
rs946069490 892 dbSNP
rs1187255559 902 dbSNP
rs981380239 908 dbSNP
rs928566114 911 dbSNP
rs1411093759 915 dbSNP
rs1419359535 931 dbSNP
rs1167030246 940 dbSNP
rs1410612335 942 dbSNP
rs576594709 943 dbSNP
rs937218726 943 dbSNP
rs536979252 944 dbSNP
rs1491434293 949 dbSNP
rs1491237356 950 dbSNP
rs1461164449 951 dbSNP
rs1055715240 952 dbSNP
rs1270937183 952 dbSNP
rs898358057 955 dbSNP
rs555279681 957 dbSNP
rs573424611 959 dbSNP
rs1439073985 968 dbSNP
rs977015981 969 dbSNP
rs886827234 971 dbSNP
rs1007904268 972 dbSNP
rs113827466 978 dbSNP
rs1332694583 981 dbSNP
rs1444980662 984 dbSNP
rs1352301398 991 dbSNP
rs1327575740 992 dbSNP
rs1030306873 993 dbSNP
rs1171541129 1000 dbSNP
rs1453636000 1004 dbSNP
rs1380681186 1006 dbSNP
rs954324315 1013 dbSNP
rs772273914 1014 dbSNP
rs1231277754 1019 dbSNP
rs772930291 1024 dbSNP
rs1282662052 1025 dbSNP
rs374661349 1030 dbSNP
rs1347695032 1033 dbSNP
rs915447741 1036 dbSNP
rs946782541 1037 dbSNP
rs561800501 1047 dbSNP
rs1278475014 1052 dbSNP
rs1448052126 1053 dbSNP
rs996864129 1054 dbSNP
rs1029233331 1056 dbSNP
rs923925976 1058 dbSNP
rs939319349 1060 dbSNP
rs773586107 1061 dbSNP
rs1160962581 1068 dbSNP
rs1417280601 1071 dbSNP
rs1176700910 1079 dbSNP
rs1056486996 1083 dbSNP
rs534415389 1085 dbSNP
rs1274564684 1091 dbSNP
rs895683452 1097 dbSNP
rs1209042595 1101 dbSNP
rs558839176 1103 dbSNP
rs115156410 1105 dbSNP
rs990311695 1106 dbSNP
rs1218336803 1109 dbSNP
rs1315661856 1118 dbSNP
rs1212720862 1120 dbSNP
rs1273375131 1124 dbSNP
rs1044198819 1127 dbSNP
rs544696401 1131 dbSNP
rs746501444 1132 dbSNP
rs562980604 1133 dbSNP
rs1340707067 1134 dbSNP
rs1470120745 1139 dbSNP
rs574874533 1140 dbSNP
rs1241883777 1143 dbSNP
rs386790272 1149 dbSNP
rs11150595 1150 dbSNP
rs967401698 1151 dbSNP
rs561249562 1152 dbSNP
rs1420172039 1153 dbSNP
rs928681178 1156 dbSNP
rs958727266 1157 dbSNP
rs991846125 1162 dbSNP
rs896923265 1171 dbSNP
rs113911928 1181 dbSNP
rs931151555 1186 dbSNP
rs1396889904 1196 dbSNP
rs542904793 1200 dbSNP
rs187212114 1205 dbSNP
rs1007182750 1206 dbSNP
rs191966958 1208 dbSNP
rs1316032967 1216 dbSNP
rs763601477 1220 dbSNP
rs1380161915 1222 dbSNP
rs150230181 1223 dbSNP
rs1040808191 1224 dbSNP
rs1443039706 1230 dbSNP
rs1392148444 1233 dbSNP
rs1162883653 1234 dbSNP
rs1460931918 1253 dbSNP
rs960824935 1256 dbSNP
rs916619657 1259 dbSNP
rs1261501431 1262 dbSNP
rs1194615879 1278 dbSNP
rs551078635 1279 dbSNP
rs559174853 1280 dbSNP
rs1376373000 1288 dbSNP
rs1044312538 1301 dbSNP
rs138815841 1302 dbSNP
rs941167037 1306 dbSNP
rs1293538334 1308 dbSNP
rs1306506748 1315 dbSNP
rs1303915865 1317 dbSNP
rs1336585117 1319 dbSNP
rs1206421029 1326 dbSNP
rs996506490 1338 dbSNP
rs896865898 1340 dbSNP
rs764687119 1348 dbSNP
rs893360192 1349 dbSNP
rs530138953 1350 dbSNP
rs548562535 1351 dbSNP
rs1171308449 1354 dbSNP
rs182162636 1354 dbSNP
rs1397364930 1362 dbSNP
rs1447908063 1366 dbSNP
rs1011709261 1379 dbSNP
rs1218592750 1383 dbSNP
rs1372657408 1384 dbSNP
rs1020373063 1387 dbSNP
rs1174675901 1393 dbSNP
rs1455901997 1396 dbSNP
rs1393648656 1399 dbSNP
rs1193600229 1409 dbSNP
rs1438873473 1410 dbSNP
rs997981704 1411 dbSNP
rs774542153 1416 dbSNP
rs1480108321 1424 dbSNP
rs1280527560 1431 dbSNP
rs762247854 1435 dbSNP
rs534223265 1437 dbSNP
rs889483604 1441 dbSNP
rs1002948620 1448 dbSNP
rs1022525752 1449 dbSNP
rs1035725857 1450 dbSNP
rs1471762291 1455 dbSNP
rs1370017395 1472 dbSNP
rs1313793311 1477 dbSNP
rs767581645 1478 dbSNP
rs999655179 1479 dbSNP
rs375428172 1480 dbSNP
rs1173347456 1482 dbSNP
rs1031176283 1484 dbSNP
rs961067227 1491 dbSNP
rs991475069 1492 dbSNP
rs1401029235 1499 dbSNP
rs186851430 1502 dbSNP
rs992294843 1511 dbSNP
rs916549618 1518 dbSNP
rs919843303 1523 dbSNP
rs1484458601 1528 dbSNP
rs1320225225 1531 dbSNP
rs149364337 1532 dbSNP
rs1205436909 1550 dbSNP
rs952617991 1556 dbSNP
rs984767607 1557 dbSNP
rs909766473 1559 dbSNP
rs1293956436 1566 dbSNP
rs941292927 1566 dbSNP
rs982692900 1572 dbSNP
rs1353750539 1577 dbSNP
rs1036819171 1582 dbSNP
rs750702610 1583 dbSNP
rs775542845 1584 dbSNP
rs933717392 1591 dbSNP
rs1050895076 1593 dbSNP
rs538377567 1596 dbSNP
rs1040838715 1598 dbSNP
rs565076239 1601 dbSNP
rs1259366679 1604 dbSNP
rs1204531202 1609 dbSNP
rs1335337837 1614 dbSNP
rs556662049 1617 dbSNP
rs1235139005 1619 dbSNP
rs1332977478 1623 dbSNP
rs1283882288 1625 dbSNP
rs529260222 1628 dbSNP
rs756182412 1629 dbSNP
rs1053423550 1630 dbSNP
rs896673738 1631 dbSNP
rs1351875190 1656 dbSNP
rs1435053483 1658 dbSNP
rs1395773877 1661 dbSNP
rs1014072339 1662 dbSNP
rs1225771861 1663 dbSNP
rs893382319 1665 dbSNP
rs969460302 1671 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084042. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep2 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uaCAUCCGGAAAUCUAGUGAa 5'
            ||:|||    |||||||| 
Target 5' agGUGGGC----AGAUCACUu 3'
14 - 30
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084042
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep2
Location of target site ENST00000262518.4 | 3UTR | CUUUGGGAGGCCGAGGUGGGCAGAUCACUUGAGGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
UCEC -0.978 0.07 -1.000 0.5 3 Click to see details
HNSC 0.399 0.19 0.500 0.13 7 Click to see details
BLCA 0.76 0.23 1.000 0.5 3 Click to see details
BRCA 0.463 0.35 0.500 0.33 3 Click to see details
BRCA 0.463 0.35 0.500 0.33 3 Click to see details
BRCA 0.463 0.35 0.500 0.33 3 Click to see details
BRCA 0.463 0.35 0.500 0.33 3 Click to see details
BRCA 0.463 0.35 0.500 0.33 3 Click to see details
109 hsa-miR-1245a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006574 BRCA2 BRCA2, DNA repair associated 2 1
MIRT055432 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT063879 RASSF8 Ras association domain family member 8 2 6
MIRT077025 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT095775 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT099172 MAP3K4 mitogen-activated protein kinase kinase kinase 4 2 2
MIRT175616 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT456518 LYPLAL1 lysophospholipase like 1 2 2
MIRT464457 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465747 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT468257 SFXN4 sideroflexin 4 2 2
MIRT469216 RICTOR RPTOR independent companion of MTOR complex 2 2 2
MIRT472045 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT481795 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT500154 CREBBP CREB binding protein 2 2
MIRT506514 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 4
MIRT506915 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT513901 GRB10 growth factor receptor bound protein 10 2 6
MIRT519128 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT528121 FOXH1 forkhead box H1 2 2
MIRT528942 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT540580 CEP89 centrosomal protein 89 2 2
MIRT545858 ZNF264 zinc finger protein 264 2 4
MIRT547147 PGM3 phosphoglucomutase 3 2 2
MIRT547434 MED4 mediator complex subunit 4 2 2
MIRT554650 ROBO1 roundabout guidance receptor 1 2 2
MIRT558524 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT559762 ABHD5 abhydrolase domain containing 5 2 2
MIRT560438 GOLGA7B golgin A7 family member B 2 2
MIRT561974 LRRC59 leucine rich repeat containing 59 2 2
MIRT562442 DDIT4 DNA damage inducible transcript 4 2 2
MIRT563489 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT568265 BMP2K BMP2 inducible kinase 2 2
MIRT572522 KIAA0232 KIAA0232 2 2
MIRT612801 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT621533 ZNF507 zinc finger protein 507 2 2
MIRT625205 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT625615 ZNF84 zinc finger protein 84 2 2
MIRT629215 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629509 AS3MT arsenite methyltransferase 2 2
MIRT629769 STK25 serine/threonine kinase 25 2 2
MIRT630908 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT632508 RAB13 RAB13, member RAS oncogene family 2 2
MIRT636871 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT637106 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637332 FAM9B family with sequence similarity 9 member B 2 2
MIRT637553 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637639 ZNF431 zinc finger protein 431 2 2
MIRT637836 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT638326 RNF11 ring finger protein 11 2 2
MIRT638393 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT642450 CLUAP1 clusterin associated protein 1 2 2
MIRT642616 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT643133 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644324 NFKBID NFKB inhibitor delta 2 2
MIRT645150 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT645673 ADK adenosine kinase 2 2
MIRT646091 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646858 SLC35E4 solute carrier family 35 member E4 2 2
MIRT650153 ZNF426 zinc finger protein 426 2 2
MIRT652483 TMEM181 transmembrane protein 181 2 2
MIRT653790 SIRPA signal regulatory protein alpha 2 2
MIRT655526 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT657077 JPH2 junctophilin 2 2 2
MIRT657322 HOOK3 hook microtubule tethering protein 3 2 2
MIRT662036 FUT2 fucosyltransferase 2 2 2
MIRT662322 ADM2 adrenomedullin 2 2 2
MIRT663211 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663559 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663937 ZNF554 zinc finger protein 554 2 2
MIRT664689 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT664709 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT665291 ZFP14 ZFP14 zinc finger protein 2 2
MIRT665572 TXNL1 thioredoxin like 1 2 2
MIRT667068 PAOX polyamine oxidase 2 2
MIRT667304 MYO5A myosin VA 2 2
MIRT667442 METTL14 methyltransferase like 14 2 2
MIRT668048 GTPBP10 GTP binding protein 10 2 2
MIRT669604 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT671088 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT674361 SLC35E3 solute carrier family 35 member E3 2 2
MIRT674962 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT676394 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676819 AGMAT agmatinase 2 2
MIRT676891 ENSA endosulfine alpha 2 2
MIRT677059 ZNF34 zinc finger protein 34 2 2
MIRT678424 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678735 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT678930 XPOT exportin for tRNA 2 2
MIRT678954 MYADM myeloid associated differentiation marker 2 2
MIRT679228 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679765 TLR6 toll like receptor 6 2 2
MIRT681992 HRH4 histamine receptor H4 2 2
MIRT687405 NSUN4 NOP2/Sun RNA methyltransferase family member 4 2 2
MIRT694570 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT698449 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT706406 HAS2 hyaluronan synthase 2 2 2
MIRT706582 ZNF432 zinc finger protein 432 2 2
MIRT706838 VHLL VHL like 2 2
MIRT706909 DVL3 dishevelled segment polarity protein 3 2 2
MIRT707052 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT708583 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT708988 CABP4 calcium binding protein 4 2 2
MIRT713041 ADRA2B adrenoceptor alpha 2B 2 2
MIRT713731 SUCO SUN domain containing ossification factor 2 2
MIRT714968 RAB21 RAB21, member RAS oncogene family 2 2
MIRT717485 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT722826 KLK2 kallikrein related peptidase 2 2 2
MIRT723305 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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