pre-miRNA Information
pre-miRNA hsa-mir-640   
Genomic Coordinates chr19: 19435063 - 19435158
Synonyms MIRN640, hsa-mir-640, MIR640
Description Homo sapiens miR-640 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-640
Sequence 61| AUGAUCCAGGAACCUGCCUCU |81
Evidence Experimental
Experiments RT-PCR
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30153378 1 COSMIC
COSN23015356 12 COSMIC
COSN30513185 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs111726405 1 dbSNP
rs765622881 2 dbSNP
rs1249744889 6 dbSNP
rs752995186 12 dbSNP
rs758746736 13 dbSNP
rs918887970 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PDE6A   
Synonyms CGPR-A, PDEA, RP43
Description phosphodiesterase 6A
Transcript NM_000440   
Expression
Putative miRNA Targets on PDE6A
3'UTR of PDE6A
(miRNA target sites are highlighted)
>PDE6A|NM_000440|3'UTR
   1 CACCACTGGGGATGTGCTGGCTGGACGGCACCACCCTTTCCTGGGAAGAGATGACTCAAGCCAGTGGAAGACCACACACC
  81 TTGAGAAGTAGAAGAGTCATAGGATTTGAAAGCTGTTAGAGAATTTAGCTTCCAGGACTGTTCAATCTTTTGGCTTCCCT
 161 GGGCCACATTGGAAGAATTGTCTTGGGTCACACATAAAATACAGTAACACTAATGATAGCTGTTGAACTTAAAAAAAAAA
 241 ATCGCCAAAAAAAAAAATTTCATAATGTTTTAAGAAAGTTTATGAATTTGTGTTGGGCCGCATTCAAAGCCGTCCTGGGC
 321 TGCATGTGGCCCACGGGCCGTGGGTTGAACAAGCTTGGCTTATACCTTATCCAGTGGCTTTTAAACATTCTTTTAGTCTT
 401 GAGAACTGCCTATTGAGCTAAAACCAATATTCTAGCTTTCATAGACATCAGTTAAACATTTAATTACATTTAATTAATGC
 481 CAGATTCACTGGCTTGCTTAGAATCATTTTTGTTCTTATACTTTCAGTTAATGTATTGTAAAAATTTTCAATCATTTTCA
 561 AAAGTAGAGAATTGTACGTTGAATCCCCACATACCCATCACCCAGATTCCAATATCAAGATTTTGCTACATGCATTTCGT
 641 CTGTCCTTTTTACATTTTCTTTTCAATTTTTTTTCTTACCTGAAGTGTTTAAAGGCAAATCCTGGCCAGGCGTGGTGGCT
 721 CACACCTGTAATCCCAGCACTTCAGGAGGCTGAGGTGGGCAGACTGCATGAGCCCAGGAGTCTGAGACCAACCTGAGCAA
 801 AATGGCAAAACCCTGTCTCTACAAAAAATACAAAAATTAGCACTCACCTGTAGTCTCAGCTACCTGGGAGGCAGAGGTGA
 881 GAGGATCTCTTGAACCCAGGAGGCGGAAGTTGCAGTGAGCTGAGATCATGCTACTGCACTCCAGCTTGGGCGACCGAGCG
 961 AGACTCTGACTCAAACAAAAGCAAAAGAAAAGGCAAATCCCAAACATATCATTTCACACCTCTACTATCTCATCTTTAAA
1041 GAAATAAGTATGTTTTCTAACATAACCACATCACTGGCCCATGCAACCAATGCCTGCCTAATACCCAGCTGTGATCTATG
1121 CTTTGATGGGCTGCACAGACCCCAAGCTTCAGCAAAGGACTTGGGACCCCACCAGCTTTGAGTGCTGTTGACAGACCCTT
1201 AGTATCAACCCCATCAGGTGTTACTGCAGCCTTCCCCAGGGTGGCCTACACCCAATGACTGATCCATGCCAGGTGGAGAG
1281 GCCTGGCCATCTTGGCTGAGCATGGGATAACTGTGCAGGGCTGTTCCAGCTCCACGACTCCTCGTGGGGTCCACTAAGGC
1361 TGTCGCTGGGCTCACATCCCAACTCGACTTCTCCCTCTGCCCACTCCTATTTCCTTCCCTTCCCCAAGCATCGGTCCCCA
1441 GGGCACTGCTTAATAAGCATCCTGCAGACTAAGTCCATTTTAGAGTCTGCTTTCTGGGACACCCAACTTGTGATGCCAGC
1521 CCTTAATCAACCTTCCTTCATTCTCATGAACGTTTTCAATGGTTGGCTTGCCTGAATCTGATCCAAACAAATTCACATAT
1601 TGAATTTAGTTGTTTCTTTTTGTTGGTTTTTAGAAAAAAGAAGATGTACTTTTTATTCTTGGATTTTTCATTGATTTCAC
1681 AGAGTATAAATTAAGTCAGATTATTCTCAATTCCAGAACTTCTGTTTCTTAAATTAGCAGGCATTCTGTTGGTTTAAAAA
1761 GATAGATGTTGGCCGGGCGCGGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGG
1841 TCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGG
1921 TGTGCACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGAAGGTTGCAGTGAGC
2001 TGAGATCATGCCACTGCACTCCAGCCTGGGCAACAAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAGAAAAAAAAAAGA
2081 TGTGGCAGATAGAATTTCTCTCTTTCTCTATCTTTCATGACGAGGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGTA
2161 TGACCATAGCTCACTGGAGCCCCAGCTGCCCGGGCTCAAGCAATCCTCCATCTCAGCTTACCAAGCAGCGGTGACCACAG
2241 GCATGCACCACCATGCCCAGCTAATTTTTTAAAACCTATCTTTGTAGACATGGGGTCTCATTCTGTTGCCCAGGCTGGCC
2321 TCAAACTCCTGACTTCAAGCAATCCTCCTGCCTCAGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACTGCACCTGG
2401 CCAGGACTTATTTCTTTTAAACCGAATCTAAGTATGTTCTGGCAAGTATGCAATACCTAGCGGAATGCACTGGCCTGATC
2481 AGCATTCATACCATAGTAACTGATGTTGAAAACAGCACAAATAAACCAGAAGTTGAAAATGGCAATAACATGCTAAAAAT
2561 TTGCAAGTCAATTTGTTACACTTGTCCAAATCTTGATTTTTTTTCCTTCTCTATCGTTCCCCCCCCACCACCAGCTTTAT
2641 GGAGGTATAATTAGCAAATAAAAAGTATACATATTTAAGGTATACACTGTGATGTTTTGATATACATTGTGAAATGGTTA
2721 CCATAATTAAGCTAATTAATATATCCATCACCTCACATAGCCATGGTTAAGTTTCTGAAGTCTCTTTTAATCTACAAAGT
2801 ACTCCTTCCTTTTTTCCATTGTCATCACCTTGCAGAAACAGAGTCAGTTTTCCCACATTCTGTATTTATCTGTTTGTTTC
2881 TTTGTGGCCGCATGTAACACATTCCTCTGTCTCATTCTAATAAATGGACATTAGCTCTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucUCCG--UCCAAGGACCUAGUa 5'
            ||||  ||||   ||||||| 
Target 5' ggAGGCCAAGGTGGGTGGATCAc 3'
1812 - 1834 161.00 -20.90
2
miRNA  3' ucuCCGUC--CA-AGGACCUAGUa 5'
             || ||   | ||:|||:||| 
Target 5' attGGAAGAATTGTCTTGGGTCAc 3'
168 - 191 136.00 -13.70
3
miRNA  3' ucUCCG--UCCAA-G------GAC-CUAGUa 5'
            ||||  ||||| |      ||| ||||| 
Target 5' ggAGGCGAAGGTTGCAGTGAGCTGAGATCAt 3'
1979 - 2009 127.00 -19.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
907806 38 ClinVar
907805 51 ClinVar
351978 126 ClinVar
907804 169 ClinVar
351977 178 ClinVar
351975 242 ClinVar
351976 242 ClinVar
351974 258 ClinVar
907803 522 ClinVar
351973 599 ClinVar
351972 608 ClinVar
906812 704 ClinVar
906811 714 ClinVar
351971 756 ClinVar
351970 796 ClinVar
906810 814 ClinVar
351969 829 ClinVar
905223 932 ClinVar
351968 938 ClinVar
351967 951 ClinVar
905222 955 ClinVar
905221 956 ClinVar
351966 1057 ClinVar
905220 1251 ClinVar
351965 1304 ClinVar
351964 1315 ClinVar
351963 1335 ClinVar
904421 1339 ClinVar
904420 1359 ClinVar
351962 1365 ClinVar
351961 1389 ClinVar
351960 1515 ClinVar
351959 1676 ClinVar
907751 1693 ClinVar
351958 1695 ClinVar
907750 1703 ClinVar
351957 1720 ClinVar
351956 1762 ClinVar
907749 1780 ClinVar
907748 1867 ClinVar
351955 1967 ClinVar
351954 2009 ClinVar
906749 2029 ClinVar
906748 2068 ClinVar
351953 2069 ClinVar
351952 2079 ClinVar
351951 2080 ClinVar
351950 2081 ClinVar
351949 2104 ClinVar
351948 2110 ClinVar
906747 2138 ClinVar
351947 2194 ClinVar
351946 2229 ClinVar
351945 2336 ClinVar
905161 2383 ClinVar
905160 2400 ClinVar
351944 2461 ClinVar
905159 2525 ClinVar
351943 2542 ClinVar
904361 2582 ClinVar
904360 2615 ClinVar
904359 2616 ClinVar
904358 2620 ClinVar
351942 2626 ClinVar
351941 2642 ClinVar
351940 2662 ClinVar
904357 2717 ClinVar
351939 2769 ClinVar
351938 2771 ClinVar
351937 2853 ClinVar
351936 2889 ClinVar
COSN31544685 3 COSMIC
COSN30761481 7 COSMIC
COSN30447758 11 COSMIC
COSN31587585 27 COSMIC
COSN30144694 28 COSMIC
COSN31565007 50 COSMIC
COSN30511479 86 COSMIC
COSN30121936 125 COSMIC
COSN31610843 159 COSMIC
COSN20102036 230 COSMIC
COSN18806738 243 COSMIC
COSN505723 246 COSMIC
COSN26487002 320 COSMIC
COSN27044900 638 COSMIC
COSN9011636 681 COSMIC
COSN20558505 2009 COSMIC
COSN21501444 2048 COSMIC
COSN29669844 2066 COSMIC
COSN14726538 2194 COSMIC
COSN27713574 2618 COSMIC
COSN17307436 2624 COSMIC
COSN22975743 2639 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs772678253 5 dbSNP
rs374146232 9 dbSNP
rs1205197252 12 dbSNP
rs770866876 13 dbSNP
rs749365205 26 dbSNP
rs370783371 27 dbSNP
rs748565237 30 dbSNP
rs756639065 31 dbSNP
rs1386797814 34 dbSNP
rs1383658823 35 dbSNP
rs1053460149 40 dbSNP
rs200445113 42 dbSNP
rs1267866023 47 dbSNP
rs372592244 51 dbSNP
rs987780159 56 dbSNP
rs1391885772 66 dbSNP
rs1430366330 72 dbSNP
rs1169223537 77 dbSNP
rs146557452 100 dbSNP
rs1358663255 119 dbSNP
rs886060216 126 dbSNP
rs1421934224 137 dbSNP
rs1304877534 145 dbSNP
rs750291729 154 dbSNP
rs981051150 160 dbSNP
rs1295896248 167 dbSNP
rs150003610 169 dbSNP
rs1229793145 172 dbSNP
rs113302481 178 dbSNP
rs1309992355 190 dbSNP
rs1416583486 199 dbSNP
rs963443788 209 dbSNP
rs1016279287 210 dbSNP
rs1464178994 214 dbSNP
rs1182559271 223 dbSNP
rs1186395762 224 dbSNP
rs1475097720 228 dbSNP
rs200340084 230 dbSNP
rs1240613204 231 dbSNP
rs1449938477 231 dbSNP
rs1032464260 234 dbSNP
rs1424542067 241 dbSNP
rs1193349428 242 dbSNP
rs36043437 242 dbSNP
rs886060215 242 dbSNP
rs999611201 244 dbSNP
rs1012895408 257 dbSNP
rs1318873727 257 dbSNP
rs1051787237 258 dbSNP
rs886060214 258 dbSNP
rs902574369 258 dbSNP
rs1489157348 260 dbSNP
rs958686768 261 dbSNP
rs757113295 262 dbSNP
rs560610090 266 dbSNP
rs1035981873 269 dbSNP
rs1465230834 271 dbSNP
rs1286550161 275 dbSNP
rs1003536649 276 dbSNP
rs1244963499 279 dbSNP
rs903398135 282 dbSNP
rs900448287 299 dbSNP
rs1319901656 300 dbSNP
rs1192956687 309 dbSNP
rs1020877773 311 dbSNP
rs1011720597 312 dbSNP
rs548574020 314 dbSNP
rs1053512936 322 dbSNP
rs1414649334 325 dbSNP
rs554874208 328 dbSNP
rs1458134516 334 dbSNP
rs536167916 335 dbSNP
rs943043317 339 dbSNP
rs1348605787 340 dbSNP
rs909052603 341 dbSNP
rs1293539793 347 dbSNP
rs1047520538 350 dbSNP
rs568988989 353 dbSNP
rs550551316 358 dbSNP
rs538329774 373 dbSNP
rs1051724240 387 dbSNP
rs1329580285 389 dbSNP
rs1227484088 396 dbSNP
rs1287510967 401 dbSNP
rs1453192430 403 dbSNP
rs1222236301 408 dbSNP
rs933235180 413 dbSNP
rs928363150 430 dbSNP
rs1180253489 436 dbSNP
rs570647556 439 dbSNP
rs1470652309 440 dbSNP
rs570846211 442 dbSNP
rs181349123 448 dbSNP
rs1407558404 451 dbSNP
rs1166057128 477 dbSNP
rs1166190787 477 dbSNP
rs909088452 496 dbSNP
rs1369366259 501 dbSNP
rs969736446 502 dbSNP
rs980564223 512 dbSNP
rs1309345426 516 dbSNP
rs1409458572 517 dbSNP
rs941850883 522 dbSNP
rs1446846432 525 dbSNP
rs909331262 526 dbSNP
rs1282158179 528 dbSNP
rs552132790 530 dbSNP
rs527652279 532 dbSNP
rs958489588 537 dbSNP
rs1273880580 538 dbSNP
rs1341522613 541 dbSNP
rs1203056689 553 dbSNP
rs1276866013 554 dbSNP
rs1268414306 556 dbSNP
rs1205736414 563 dbSNP
rs560129721 565 dbSNP
rs1032527807 568 dbSNP
rs1474000721 577 dbSNP
rs1184727113 578 dbSNP
rs1390049598 581 dbSNP
rs958740548 585 dbSNP
rs150867395 599 dbSNP
rs981434155 601 dbSNP
rs4705389 608 dbSNP
rs563093690 613 dbSNP
rs1267176760 619 dbSNP
rs752333642 625 dbSNP
rs1331871680 627 dbSNP
rs997959825 631 dbSNP
rs1222125779 635 dbSNP
rs1448548908 637 dbSNP
rs1011774328 638 dbSNP
rs900498338 639 dbSNP
rs1039407284 659 dbSNP
rs190145786 663 dbSNP
rs762755139 665 dbSNP
rs77010487 665 dbSNP
rs76578939 667 dbSNP
rs765003858 668 dbSNP
rs1047572778 675 dbSNP
rs929123099 675 dbSNP
rs1007312586 676 dbSNP
rs1204668472 680 dbSNP
rs576995175 687 dbSNP
rs760932127 688 dbSNP
rs141523910 694 dbSNP
rs1385483613 695 dbSNP
rs948427384 697 dbSNP
rs1294647066 702 dbSNP
rs777001495 704 dbSNP
rs1170426201 708 dbSNP
rs1403844322 712 dbSNP
rs1398735404 714 dbSNP
rs1319574063 740 dbSNP
rs990196761 741 dbSNP
rs1437178157 748 dbSNP
rs1296256922 751 dbSNP
rs1232558471 756 dbSNP
rs4705388 756 dbSNP
rs1036269525 757 dbSNP
rs1347315225 762 dbSNP
rs1224371156 769 dbSNP
rs1267877583 772 dbSNP
rs1463879201 783 dbSNP
rs941903450 788 dbSNP
rs1263112576 794 dbSNP
rs1451560571 795 dbSNP
rs4705387 796 dbSNP
rs1378872030 798 dbSNP
rs1428890882 810 dbSNP
rs991245480 811 dbSNP
rs1158043666 812 dbSNP
rs1458662327 814 dbSNP
rs966861318 814 dbSNP
rs1174167224 819 dbSNP
rs866242642 822 dbSNP
rs1389874797 829 dbSNP
rs886060213 829 dbSNP
rs147330909 831 dbSNP
rs372312525 847 dbSNP
rs1347531110 875 dbSNP
rs760898022 876 dbSNP
rs536546940 878 dbSNP
rs1327502982 879 dbSNP
rs1230573158 881 dbSNP
rs1191541058 883 dbSNP
rs928705062 900 dbSNP
rs981866154 904 dbSNP
rs575491812 905 dbSNP
rs1490380979 906 dbSNP
rs1180976798 916 dbSNP
rs1020986048 928 dbSNP
rs1249099858 929 dbSNP
rs990393994 932 dbSNP
rs1317949517 934 dbSNP
rs1159482351 936 dbSNP
rs886060212 938 dbSNP
rs557104958 939 dbSNP
rs565361431 951 dbSNP
rs1230539971 952 dbSNP
rs185298177 956 dbSNP
rs953266761 959 dbSNP
rs1030063636 960 dbSNP
rs997619835 962 dbSNP
rs1340312123 976 dbSNP
rs540793961 978 dbSNP
rs1045932736 979 dbSNP
rs552218908 990 dbSNP
rs1203759474 993 dbSNP
rs1375388128 1006 dbSNP
rs1333893102 1008 dbSNP
rs1271862342 1010 dbSNP
rs897480399 1017 dbSNP
rs534037061 1020 dbSNP
rs1483800157 1025 dbSNP
rs1177485626 1027 dbSNP
rs1447657067 1031 dbSNP
rs1036274744 1044 dbSNP
rs1255213042 1055 dbSNP
rs144135425 1057 dbSNP
rs368514183 1073 dbSNP
rs1189512070 1075 dbSNP
rs1301333372 1080 dbSNP
rs887659353 1086 dbSNP
rs867780088 1113 dbSNP
rs1385737351 1118 dbSNP
rs1429067609 1119 dbSNP
rs1368853609 1124 dbSNP
rs1463714673 1126 dbSNP
rs1298997669 1127 dbSNP
rs137886002 1131 dbSNP
rs1401910826 1136 dbSNP
rs548402828 1139 dbSNP
rs773401912 1140 dbSNP
rs1378421090 1144 dbSNP
rs1394601032 1153 dbSNP
rs1176576964 1163 dbSNP
rs1384091941 1167 dbSNP
rs1294753215 1168 dbSNP
rs894195118 1172 dbSNP
rs1438828836 1183 dbSNP
rs1055563987 1185 dbSNP
rs937169164 1194 dbSNP
rs928737621 1210 dbSNP
rs1045804208 1213 dbSNP
rs1054153396 1222 dbSNP
rs946074750 1224 dbSNP
rs1243537600 1227 dbSNP
rs1448775805 1230 dbSNP
rs935641864 1237 dbSNP
rs1457277357 1238 dbSNP
rs925561275 1242 dbSNP
rs768662613 1253 dbSNP
rs530410682 1255 dbSNP
rs913230158 1264 dbSNP
rs536716222 1266 dbSNP
rs978337750 1278 dbSNP
rs1358760748 1285 dbSNP
rs1198225673 1288 dbSNP
rs1484051493 1302 dbSNP
rs886060211 1304 dbSNP
rs1339039567 1307 dbSNP
rs945571747 1312 dbSNP
rs144468326 1315 dbSNP
rs1319179994 1318 dbSNP
rs976627511 1320 dbSNP
rs957617131 1326 dbSNP
rs1310010638 1329 dbSNP
rs1018085495 1332 dbSNP
rs879722083 1335 dbSNP
rs1241440685 1337 dbSNP
rs911447952 1339 dbSNP
rs1382682511 1340 dbSNP
rs985650219 1341 dbSNP
rs1486171224 1344 dbSNP
rs955553780 1348 dbSNP
rs551130416 1359 dbSNP
rs1026225720 1361 dbSNP
rs1431643911 1364 dbSNP
rs888895 1365 dbSNP
rs962056978 1366 dbSNP
rs1457090966 1369 dbSNP
rs1157435887 1381 dbSNP
rs565493276 1382 dbSNP
rs534149640 1386 dbSNP
rs886060210 1389 dbSNP
rs1406359728 1393 dbSNP
rs887716613 1396 dbSNP
rs540287013 1399 dbSNP
rs1288460975 1403 dbSNP
rs1328069950 1405 dbSNP
rs1418871287 1409 dbSNP
rs528245199 1410 dbSNP
rs1055621968 1415 dbSNP
rs1358325791 1422 dbSNP
rs560932756 1423 dbSNP
rs1220817350 1427 dbSNP
rs77528113 1433 dbSNP
rs1489892428 1439 dbSNP
rs1201830789 1446 dbSNP
rs1269810843 1448 dbSNP
rs1472407180 1450 dbSNP
rs115876552 1461 dbSNP
rs556949573 1462 dbSNP
rs1367787794 1470 dbSNP
rs902854788 1493 dbSNP
rs1164738218 1499 dbSNP
rs1041371011 1503 dbSNP
rs1046274841 1507 dbSNP
rs536740900 1515 dbSNP
rs1256454532 1516 dbSNP
rs1215360660 1517 dbSNP
rs193167339 1518 dbSNP
rs1288678303 1519 dbSNP
rs1217805655 1520 dbSNP
rs1356313146 1525 dbSNP
rs1349423044 1536 dbSNP
rs1264182929 1547 dbSNP
rs1054472937 1550 dbSNP
rs1373870315 1551 dbSNP
rs1341100456 1552 dbSNP
rs1295144635 1560 dbSNP
rs935969077 1563 dbSNP
rs1398447516 1570 dbSNP
rs976300899 1576 dbSNP
rs1342605952 1578 dbSNP
rs1224769216 1580 dbSNP
rs372074956 1591 dbSNP
rs577378229 1600 dbSNP
rs910670789 1601 dbSNP
rs984836873 1607 dbSNP
rs952089477 1608 dbSNP
rs1181658276 1613 dbSNP
rs1383882045 1614 dbSNP
rs919265244 1616 dbSNP
rs1161347959 1617 dbSNP
rs1369460775 1619 dbSNP
rs1458995412 1624 dbSNP
rs985701157 1626 dbSNP
rs1192289515 1632 dbSNP
rs1476675844 1633 dbSNP
rs1330522054 1634 dbSNP
rs972007139 1642 dbSNP
rs971364595 1645 dbSNP
rs955768281 1649 dbSNP
rs922796732 1650 dbSNP
rs1024632092 1652 dbSNP
rs552752599 1666 dbSNP
rs1246642116 1669 dbSNP
rs115580452 1676 dbSNP
rs1341632807 1682 dbSNP
rs961832254 1682 dbSNP
rs1032807572 1687 dbSNP
rs751489226 1689 dbSNP
rs116427816 1693 dbSNP
rs867317358 1695 dbSNP
rs1357654609 1696 dbSNP
rs1041422721 1700 dbSNP
rs149268409 1703 dbSNP
rs902120695 1710 dbSNP
rs74869635 1720 dbSNP
rs1001458498 1723 dbSNP
rs753755619 1724 dbSNP
rs1419743172 1726 dbSNP
rs907075940 1735 dbSNP
rs1024150771 1743 dbSNP
rs1320330058 1746 dbSNP
rs1413563104 1749 dbSNP
rs910711135 1760 dbSNP
rs868404248 1762 dbSNP
rs891903963 1763 dbSNP
rs1054531033 1765 dbSNP
rs1362967774 1773 dbSNP
rs936021302 1774 dbSNP
rs1321526413 1775 dbSNP
rs889787812 1776 dbSNP
rs1050151242 1778 dbSNP
rs934266202 1779 dbSNP
rs184935833 1780 dbSNP
rs569253499 1781 dbSNP
rs972942356 1782 dbSNP
rs752310919 1786 dbSNP
rs550955240 1790 dbSNP
rs907660915 1791 dbSNP
rs971798210 1793 dbSNP
rs1242210596 1798 dbSNP
rs984499470 1799 dbSNP
rs951755684 1800 dbSNP
rs1245403539 1810 dbSNP
rs1201457064 1825 dbSNP
rs1033980582 1839 dbSNP
rs779746809 1842 dbSNP
rs1173899357 1847 dbSNP
rs980142616 1851 dbSNP
rs1431120267 1856 dbSNP
rs1470076337 1860 dbSNP
rs1158182756 1864 dbSNP
rs1382608643 1866 dbSNP
rs971352928 1867 dbSNP
rs958616986 1870 dbSNP
rs1327168351 1883 dbSNP
rs532861991 1890 dbSNP
rs1196852671 1910 dbSNP
rs1191018104 1912 dbSNP
rs191275348 1917 dbSNP
rs1258950280 1922 dbSNP
rs547258835 1923 dbSNP
rs1224463042 1925 dbSNP
rs1267900120 1926 dbSNP
rs891626465 1941 dbSNP
rs1207472183 1943 dbSNP
rs1261817531 1944 dbSNP
rs1033132970 1948 dbSNP
rs1343125372 1952 dbSNP
rs1000283036 1958 dbSNP
rs538582690 1967 dbSNP
rs560849875 1968 dbSNP
rs1181113601 1976 dbSNP
rs1361905280 1976 dbSNP
rs1455277793 1983 dbSNP
rs867719133 1984 dbSNP
rs1371706741 1985 dbSNP
rs1330537884 1986 dbSNP
rs1424044906 1993 dbSNP
rs1301406411 1998 dbSNP
rs901446703 2001 dbSNP
rs2005909 2009 dbSNP
rs940228622 2010 dbSNP
rs186953654 2014 dbSNP
rs1241772416 2017 dbSNP
rs1261880499 2025 dbSNP
rs1356294129 2029 dbSNP
rs1219530295 2036 dbSNP
rs1293333582 2041 dbSNP
rs1413622869 2041 dbSNP
rs1422579330 2048 dbSNP
rs1204083627 2049 dbSNP
rs1248111723 2050 dbSNP
rs1174726415 2051 dbSNP
rs1248007486 2052 dbSNP
rs1211251865 2053 dbSNP
rs1177239190 2055 dbSNP
rs1441635357 2059 dbSNP
rs1182284376 2060 dbSNP
rs251458 2068 dbSNP
rs5872149 2068 dbSNP
rs57328066 2069 dbSNP
rs200764747 2070 dbSNP
rs879457210 2070 dbSNP
rs1280972860 2071 dbSNP
rs1201987630 2072 dbSNP
rs1348278583 2073 dbSNP
rs1393455869 2074 dbSNP
rs1308453351 2076 dbSNP
rs1237798524 2077 dbSNP
rs1244489914 2078 dbSNP
rs1226210956 2079 dbSNP
rs1359580983 2079 dbSNP
rs1387135700 2079 dbSNP
rs374027518 2079 dbSNP
rs537673902 2079 dbSNP
rs764134058 2079 dbSNP
rs765560207 2079 dbSNP
rs886060209 2080 dbSNP
rs1379017983 2081 dbSNP
rs886060208 2081 dbSNP
rs1020032261 2083 dbSNP
rs1371479669 2087 dbSNP
rs1446620556 2100 dbSNP
rs886060207 2104 dbSNP
rs997893582 2108 dbSNP
rs759816 2110 dbSNP
rs796891797 2111 dbSNP
rs1360220401 2112 dbSNP
rs1384211766 2112 dbSNP
rs1213435300 2116 dbSNP
rs1292830688 2116 dbSNP
rs1308836307 2121 dbSNP
rs1227781798 2131 dbSNP
rs930404355 2137 dbSNP
rs756742673 2138 dbSNP
rs1008232298 2142 dbSNP
rs1243632420 2170 dbSNP
rs889335031 2176 dbSNP
rs534466618 2178 dbSNP
rs1381443387 2180 dbSNP
rs544857591 2191 dbSNP
rs1430514628 2192 dbSNP
rs30886 2194 dbSNP
rs552738666 2208 dbSNP
rs917208130 2217 dbSNP
rs1179072465 2226 dbSNP
rs1407397729 2228 dbSNP
rs115656079 2229 dbSNP
rs548710106 2230 dbSNP
rs955901800 2238 dbSNP
rs1032851988 2239 dbSNP
rs1282299774 2240 dbSNP
rs1343283424 2245 dbSNP
rs1225081148 2248 dbSNP
rs1263539638 2258 dbSNP
rs573264866 2260 dbSNP
rs937274373 2261 dbSNP
rs925841616 2264 dbSNP
rs1486917027 2265 dbSNP
rs10043629 2270 dbSNP
rs1194505201 2275 dbSNP
rs554735136 2276 dbSNP
rs954126856 2278 dbSNP
rs1020084477 2289 dbSNP
rs769216644 2293 dbSNP
rs536764290 2305 dbSNP
rs998223821 2313 dbSNP
rs965121192 2323 dbSNP
rs30885 2336 dbSNP
rs1453797155 2348 dbSNP
rs1302027487 2356 dbSNP
rs1415077928 2357 dbSNP
rs113729857 2358 dbSNP
rs1296785052 2361 dbSNP
rs1406448771 2363 dbSNP
rs889396794 2367 dbSNP
rs1372397333 2378 dbSNP
rs1004426570 2382 dbSNP
rs77109719 2383 dbSNP
rs1217346272 2385 dbSNP
rs1291151108 2386 dbSNP
rs1164645070 2391 dbSNP
rs1048558426 2392 dbSNP
rs1489917381 2394 dbSNP
rs898003539 2395 dbSNP
rs1355757797 2396 dbSNP
rs74771814 2400 dbSNP
rs1469993176 2401 dbSNP
rs950192638 2404 dbSNP
rs547195685 2407 dbSNP
rs1440854942 2410 dbSNP
rs1162358940 2411 dbSNP
rs1363240716 2415 dbSNP
rs1426127450 2423 dbSNP
rs927088817 2432 dbSNP
rs1163898054 2433 dbSNP
rs1056222963 2437 dbSNP
rs1477640722 2443 dbSNP
rs534880825 2449 dbSNP
rs1373895404 2456 dbSNP
rs1245229365 2457 dbSNP
rs551329710 2461 dbSNP
rs978671593 2462 dbSNP
rs945906894 2466 dbSNP
rs1290802854 2475 dbSNP
rs567865002 2478 dbSNP
rs548763561 2492 dbSNP
rs752529909 2499 dbSNP
rs1437498436 2500 dbSNP
rs530632768 2504 dbSNP
rs746054170 2506 dbSNP
rs111440604 2525 dbSNP
rs551002606 2532 dbSNP
rs1242635027 2534 dbSNP
rs30884 2542 dbSNP
rs1183554040 2545 dbSNP
rs965518387 2552 dbSNP
rs559249270 2561 dbSNP
rs925834721 2574 dbSNP
rs978612782 2575 dbSNP
rs1418265721 2578 dbSNP
rs953998578 2580 dbSNP
rs952382210 2583 dbSNP
rs1330623737 2584 dbSNP
rs540946744 2595 dbSNP
rs998676408 2597 dbSNP
rs573718233 2600 dbSNP
rs1451817792 2605 dbSNP
rs879779624 2605 dbSNP
rs1384920571 2607 dbSNP
rs1454583724 2613 dbSNP
rs965453260 2615 dbSNP
rs777837397 2616 dbSNP
rs750630343 2617 dbSNP
rs898054450 2619 dbSNP
rs188603235 2620 dbSNP
rs542706002 2621 dbSNP
rs758455690 2623 dbSNP
rs183299988 2624 dbSNP
rs367679417 2626 dbSNP
rs1043042673 2627 dbSNP
rs1334889004 2627 dbSNP
rs202239422 2627 dbSNP
rs945957451 2629 dbSNP
rs569137634 2642 dbSNP
rs1272090861 2645 dbSNP
rs1341368326 2648 dbSNP
rs1430094676 2651 dbSNP
rs557379826 2652 dbSNP
rs1190402417 2655 dbSNP
rs905355607 2659 dbSNP
rs150127383 2662 dbSNP
rs1226323728 2680 dbSNP
rs949847155 2702 dbSNP
rs1282934906 2704 dbSNP
rs1248366827 2706 dbSNP
rs1213797121 2707 dbSNP
rs911003892 2712 dbSNP
rs1263368084 2714 dbSNP
rs578087908 2717 dbSNP
rs1431221394 2721 dbSNP
rs778443310 2731 dbSNP
rs934294409 2741 dbSNP
rs1157986624 2747 dbSNP
rs1382718211 2751 dbSNP
rs925886821 2752 dbSNP
rs1398958331 2757 dbSNP
rs919607113 2766 dbSNP
rs78827133 2769 dbSNP
rs17110632 2771 dbSNP
rs921100849 2793 dbSNP
rs1347855754 2799 dbSNP
rs765952634 2803 dbSNP
rs1234586398 2806 dbSNP
rs1015163573 2816 dbSNP
rs965859377 2826 dbSNP
rs1014870825 2828 dbSNP
rs1286132024 2832 dbSNP
rs1490076998 2844 dbSNP
rs1370389691 2849 dbSNP
rs1327113448 2850 dbSNP
rs73796297 2853 dbSNP
rs1270764541 2872 dbSNP
rs1398127821 2877 dbSNP
rs1433498739 2879 dbSNP
rs1180829980 2880 dbSNP
rs982770260 2883 dbSNP
rs1361955461 2888 dbSNP
rs757612877 2889 dbSNP
rs1381044270 2890 dbSNP
rs1462744175 2894 dbSNP
rs549601359 2899 dbSNP
rs1393162885 2905 dbSNP
rs1387636390 2909 dbSNP
rs1328637052 2922 dbSNP
rs1334452089 2933 dbSNP
rs1002872058 2937 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084040. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep1 HITS-CLIP data was present in GSM1084042. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep2 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ucUCCGUCCAAGGACCUAGUa 5'
            |||::||    ||||||| 
Target 5' caAGGUGGG----UGGAUCAc 3'
1 - 17
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_000440 | 3UTR | UCACGCCUGUAAUUCCAGCACUUUGGGAGGCCAAGGUGGGUGGAUCACCUGAGGUCAGGAGUUCAAGACCAGCCUGGCCAACAUGGUGAAACCCCAUCUCUACUAAAAAUACAAAAAUUAGCUGGGUGUGGUGGUGUGCACCUGUAAUCCCAGCUACUCAGGAGGCUGAGGCAGGAGAAUCGCUUGAACCUGGGAGGCGAAGGUUGCAGUGAGCUGAGAUCAUGCCACUGCACUCCAGCCUGGGCAACAAGAGCAAGACUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_000440 | 3UTR | CUUUGGGAGGCCAAGGUGGGUGGAUCACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084040
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep1
Location of target site ENST00000255266.5 | 3UTR | AGGCCAAGGUGGGUGGAUCACCUGAGGUCAGGAGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084042
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep2
Location of target site ENST00000255266.5 | 3UTR | CAAGGUGGGUGGAUCACCUGAGGUCAGGAGUUCAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE19783 ER- ER- breast cancer 0.268 8.5e-3 0.246 1.4e-2 79 Click to see details
GSE28260 Renal cortex and medulla 0.6 1.5e-2 0.625 1.1e-2 13 Click to see details
GSE19536 Breast cancer 0.203 2.1e-2 0.163 5.3e-2 100 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.381 3.0e-2 -0.397 2.5e-2 25 Click to see details
GSE28544 Breast cancer -0.37 3.8e-2 -0.339 5.3e-2 24 Click to see details
GSE38226 Liver fibrosis -0.383 4.3e-2 -0.420 2.9e-2 21 Click to see details
GSE26953 Aortic valvular endothelial cells -0.336 5.4e-2 -0.379 3.4e-2 24 Click to see details
GSE32688 Pancreatic cancer 0.288 5.5e-2 0.265 7.1e-2 32 Click to see details
GSE21849 B cell lymphoma -0.185 1.7e-1 0.364 2.6e-2 29 Click to see details
GSE17306 Multiple myeloma 0.132 1.8e-1 0.263 3.4e-2 49 Click to see details
GSE17498 Multiple myeloma -0.146 1.8e-1 -0.167 1.5e-1 40 Click to see details
GSE27834 Pluripotent stem cells 0.238 1.9e-1 0.344 9.6e-2 16 Click to see details
GSE19783 ER+ ER+ breast cancer -0.18 2.2e-1 -0.132 2.9e-1 20 Click to see details
GSE14794 Lymphoblastoid cells -0.08 2.3e-1 -0.105 1.6e-1 90 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.076 3.8e-1 -0.138 2.8e-1 20 Click to see details
GSE19350 CNS germ cell tumors 0.1 3.8e-1 0.119 3.6e-1 12 Click to see details
GSE42095 Differentiated embryonic stem cells -0.032 4.4e-1 0.000 5.0e-1 23 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.023 4.6e-1 -0.002 5.0e-1 25 Click to see details
GSE21687 Ependynoma primary tumors 0.008 4.7e-1 -0.046 3.6e-1 64 Click to see details
GSE21687 Ependynoma primary tumors 0.008 4.7e-1 -0.046 3.6e-1 64 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
194 hsa-miR-640 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT097121 TNPO1 transportin 1 2 2
MIRT115090 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 4
MIRT204603 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204634 MOB4 MOB family member 4, phocein 2 8
MIRT344451 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT405772 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT445876 SENP6 SUMO1/sentrin specific peptidase 6 2 2
MIRT497418 FAM46A family with sequence similarity 46 member A 2 2
MIRT504394 HMX2 H6 family homeobox 2 2 4
MIRT504691 SLCO2B1 solute carrier organic anion transporter family member 2B1 2 8
MIRT512386 MTRNR2L3 MT-RNR2-like 3 2 6
MIRT513003 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT513084 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT519122 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT523836 F2RL1 F2R like trypsin receptor 1 2 2
MIRT565356 TMCC1 transmembrane and coiled-coil domain family 1 2 2
MIRT575895 Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT576894 Poteg POTE ankyrin domain family, member G 2 2
MIRT613780 RPS6 ribosomal protein S6 2 2
MIRT613934 POLR3A RNA polymerase III subunit A 2 2
MIRT614348 LOH12CR1 BLOC-1 related complex subunit 5 2 2
MIRT614534 NOA1 nitric oxide associated 1 2 2
MIRT617019 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT618247 MANEAL mannosidase endo-alpha like 2 2
MIRT619051 TTC4 tetratricopeptide repeat domain 4 2 2
MIRT619442 ZNF517 zinc finger protein 517 2 2
MIRT619723 FPR2 formyl peptide receptor 2 2 2
MIRT620179 TRIM72 tripartite motif containing 72 2 2
MIRT620370 ANKRD62 ankyrin repeat domain 62 2 2
MIRT621263 RTN2 reticulon 2 2 2
MIRT621463 APOH apolipoprotein H 2 2
MIRT621571 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT621683 TSPYL1 TSPY like 1 2 2
MIRT622866 PDE7A phosphodiesterase 7A 2 2
MIRT624669 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT625607 ZNF84 zinc finger protein 84 2 2
MIRT626111 IL23R interleukin 23 receptor 2 2
MIRT628380 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT628553 MELK maternal embryonic leucine zipper kinase 2 2
MIRT628671 C2orf72 chromosome 2 open reading frame 72 2 2
MIRT628747 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT628776 TMEM154 transmembrane protein 154 2 2
MIRT628918 ZNF430 zinc finger protein 430 2 2
MIRT629174 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT629209 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629267 SLC5A8 solute carrier family 5 member 8 2 2
MIRT629498 AS3MT arsenite methyltransferase 2 2
MIRT629665 USP1 ubiquitin specific peptidase 1 2 2
MIRT629760 STK25 serine/threonine kinase 25 2 2
MIRT630899 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT631105 SLC15A2 solute carrier family 15 member 2 2 2
MIRT631112 ATCAY ATCAY, caytaxin 2 2
MIRT631450 DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 2 2
MIRT631505 FFAR4 free fatty acid receptor 4 2 2
MIRT631580 ITGAL integrin subunit alpha L 2 2
MIRT631836 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT632342 SWSAP1 SWIM-type zinc finger 7 associated protein 1 2 2
MIRT633214 ZNF584 zinc finger protein 584 2 2
MIRT633223 ZNF43 zinc finger protein 43 2 2
MIRT633480 ARIH2OS ariadne RBR E3 ubiquitin protein ligase 2 opposite strand 2 2
MIRT633511 LRRC27 leucine rich repeat containing 27 2 2
MIRT633615 CWF19L1 CWF19 like 1, cell cycle control (S. pombe) 2 2
MIRT633652 SLC28A1 solute carrier family 28 member 1 2 2
MIRT633677 ZNF576 zinc finger protein 576 2 2
MIRT634196 TMOD2 tropomodulin 2 2 4
MIRT634388 PLSCR1 phospholipid scramblase 1 2 2
MIRT635817 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT635962 TTC31 tetratricopeptide repeat domain 31 2 2
MIRT636114 YPEL1 yippee like 1 2 2
MIRT636164 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636768 CLUAP1 clusterin associated protein 1 2 2
MIRT637092 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637316 FAM9B family with sequence similarity 9 member B 2 2
MIRT637540 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637628 ZNF431 zinc finger protein 431 2 2
MIRT637826 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT637945 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT637968 IRF1 interferon regulatory factor 1 2 2
MIRT638321 RNF11 ring finger protein 11 2 2
MIRT638386 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT639244 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT642608 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT642793 SLC1A5 solute carrier family 1 member 5 2 2
MIRT643847 LACTB lactamase beta 2 4
MIRT644705 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT645148 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT646671 CCDC69 coiled-coil domain containing 69 2 2
MIRT647780 ASB8 ankyrin repeat and SOCS box containing 8 2 2
MIRT648554 WDR92 WD repeat domain 92 2 2
MIRT648990 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT649099 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT650141 ZNF426 zinc finger protein 426 2 2
MIRT650791 GSR glutathione-disulfide reductase 2 2
MIRT654967 PLEKHA2 pleckstrin homology domain containing A2 2 2
MIRT655099 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT655516 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT656289 METTL14 methyltransferase like 14 2 2
MIRT656497 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657074 JPH2 junctophilin 2 2 2
MIRT657314 HOOK3 hook microtubule tethering protein 3 2 2
MIRT657419 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT659032 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659535 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT661532 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT662029 FUT2 fucosyltransferase 2 2 2
MIRT663206 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663357 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT663557 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663650 POLM DNA polymerase mu 2 2
MIRT663694 ABHD17B abhydrolase domain containing 17B 2 2
MIRT664370 CYB5A cytochrome b5 type A 2 2
MIRT664783 LIAS lipoic acid synthetase 2 4
MIRT665561 TXNL1 thioredoxin like 1 2 2
MIRT665950 TAOK1 TAO kinase 1 2 2
MIRT667338 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT667804 ITIH5 inter-alpha-trypsin inhibitor heavy chain family member 5 2 2
MIRT668804 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT669470 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT669599 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT669806 STOML1 stomatin like 1 2 2
MIRT669944 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT670292 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670381 EMP2 epithelial membrane protein 2 2 2
MIRT670481 DCUN1D2 defective in cullin neddylation 1 domain containing 2 2 2
MIRT670531 KIF1C kinesin family member 1C 2 4
MIRT670565 GLTP glycolipid transfer protein 2 2
MIRT670603 NPHP1 nephrocystin 1 2 2
MIRT670880 CYTIP cytohesin 1 interacting protein 2 2
MIRT670931 LIPG lipase G, endothelial type 2 2
MIRT671261 MTRNR2L5 MT-RNR2-like 5 2 2
MIRT671794 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT671897 GBP4 guanylate binding protein 4 2 2
MIRT672000 SLC35F6 solute carrier family 35 member F6 2 4
MIRT672074 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT672319 C9orf3 chromosome 9 open reading frame 3 2 2
MIRT672853 C22orf29 retrotransposon Gag like 10 2 2
MIRT673395 WNT7B Wnt family member 7B 2 2
MIRT673537 DEGS1 delta 4-desaturase, sphingolipid 1 2 2
MIRT674285 ZNF724P zinc finger protein 724 2 2
MIRT674494 TIRAP TIR domain containing adaptor protein 2 2
MIRT675460 NUBPL nucleotide binding protein like 2 2
MIRT675569 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT676068 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676254 PBOV1 prostate and breast cancer overexpressed 1 2 2
MIRT676377 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676758 SNX2 sorting nexin 2 2 2
MIRT676773 NPHS1 NPHS1, nephrin 2 2
MIRT676874 ENSA endosulfine alpha 2 2
MIRT676918 KLHDC8A kelch domain containing 8A 2 2
MIRT676944 S1PR3 sphingosine-1-phosphate receptor 3 2 2
MIRT676957 HFE hemochromatosis 2 2
MIRT676967 RNF19B ring finger protein 19B 2 2
MIRT676972 ZNF708 zinc finger protein 708 2 2
MIRT677042 ZNF34 zinc finger protein 34 2 2
MIRT677070 VMAC vimentin type intermediate filament associated coiled-coil protein 2 2
MIRT677093 MFSD11 major facilitator superfamily domain containing 11 2 4
MIRT677134 P2RX7 purinergic receptor P2X 7 2 2
MIRT677179 ZNF786 zinc finger protein 786 2 2
MIRT677228 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677320 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT677455 PDLIM3 PDZ and LIM domain 3 2 2
MIRT677809 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT677937 ZNF519 zinc finger protein 519 2 2
MIRT678063 UBN2 ubinuclein 2 2 4
MIRT678072 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678252 FXN frataxin 2 2
MIRT678315 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678367 XIAP X-linked inhibitor of apoptosis 2 4
MIRT678372 RNF115 ring finger protein 115 2 2
MIRT678410 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678518 ZNF347 zinc finger protein 347 2 2
MIRT678566 CDK4 cyclin dependent kinase 4 2 2
MIRT678580 PPP1R3B protein phosphatase 1 regulatory subunit 3B 2 2
MIRT678820 PDE6A phosphodiesterase 6A 2 2
MIRT678917 XPOT exportin for tRNA 2 2
MIRT679217 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679437 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT679595 HILPDA hypoxia inducible lipid droplet associated 2 2
MIRT679755 TLR6 toll like receptor 6 2 2
MIRT679800 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 2 2
MIRT680057 CD96 CD96 molecule 2 2
MIRT680116 CCDC30 coiled-coil domain containing 30 2 4
MIRT680181 ZNF554 zinc finger protein 554 2 2
MIRT680439 WDR12 WD repeat domain 12 2 2
MIRT680789 ZNF578 zinc finger protein 578 2 2
MIRT692464 APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2 2 2
MIRT702952 HIP1 huntingtin interacting protein 1 2 2
MIRT706016 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT706032 F2R coagulation factor II thrombin receptor 2 2
MIRT706135 MTRNR2L10 MT-RNR2-like 10 2 2
MIRT706394 HAS2 hyaluronan synthase 2 2 2
MIRT713293 DCP2 decapping mRNA 2 2 2
MIRT716583 BRAP BRCA1 associated protein 2 2
MIRT720433 C19orf47 chromosome 19 open reading frame 47 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-640 Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer tissue and cell line (SKOV3)
hsa-miR-640 Cetuximab resistant High Colon Cancer cell line
hsa-miR-640 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Mitoxantrone 4212 NSC279836 approved resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-640 Sorafenib 216239 NSC747971 approved sensitive Low Clear Cell Renal Cell Carcinoma cell line (786-O)
hsa-mir-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-640 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-640 Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-640 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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