pre-miRNA Information
pre-miRNA hsa-mir-23a   
Genomic Coordinates chr19: 13836587 - 13836659
Synonyms MIRN23A, hsa-mir-23a, miRNA23A, MIR23A
Description Homo sapiens miR-23a stem-loop
Comment This miRNA was previously named miR-23 . This finding was later retracted after the discovery that the regulated gene was human homolog of ES1 (HES1), whose function is unknown.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-23a-5p
Sequence 9| GGGGUUCCUGGGGAUGGGAUUU |30
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs748509260 12 dbSNP
rs1205403719 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol LACTB   
Synonyms G24, MRPL56
Description lactamase beta
Transcript NM_171846   
Other Transcripts NM_032857   
Expression
Putative miRNA Targets on LACTB
3'UTR of LACTB
(miRNA target sites are highlighted)
>LACTB|NM_171846|3'UTR
   1 ATGAATACCTTCTGCTGTGTCTAGCTATATCGCATCTTAACACTATTTTATTAATTAAAAGTCAAATTTTCTTTGTTTCC
  81 ATTCCAAAATCAACCTGCCACATTTTGGGAGCTTTTCTACATGTCTGTTTTCTCATCTGTAAAGTGAAGGAAGTAAAACA
 161 TGTTTATAAAGTACACTAAGACCCTTTGATGAAAGATAGCAATAATATTAATAATTCAAACATGAATAACTAAACCAAAA
 241 TTGCACCCACCATGAGCATCTGTAATTTGCTCTTTAACCATTCCTTTTTTAGGTTTTAACTAATACTTTGTTTACGTGTT
 321 ATTAGTTTTTAATTGTTTTCATACTGTTTTGAAATAATTTTATACTTATAGAAAAGTTGCAAGAGTAGTACAAAGGATTC
 401 ACATATCCTCTTTACTCAGATTCCCTTAATGTTAGTTTACCGCATTTGCATTACCTTTCTGTCTACATATGTGTTTGTTT
 481 CTGAACCATTTGGAAATAAGTTGTAGACGTGATACCCCTTTACCTATAAATATTTACATGTGTATTTTCTAAAAACAAGG
 561 ACATTCAGGGCCGGGTGCAGTGGCTCACGCCTGTAATCCCAACACTTTGGAAGGCCGAGGTGGGTGGATCACCTGAGGTC
 641 AGGAGTTCAAGACCAGCCTGGCCAATGTGGTGAAATCAACCCTCTCTCTACTAAAAATGCAAAAATTAGCCAGGTGTGGT
 721 GGCGGGTGCCTATAATCCCAGCCACGCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGAGTTGCAGTAAG
 801 CCAAGATCGTGCCCCTGCACTTCAGGCTGGGCGAAAGAGTGAGACTCCATGTCAAAAAAGGAAAAAAAAAAAAAAAAAAA
 881 GGACATTTGGGAAATTAACATAGATACAATGCTTTTATTAAATCTACAGACCTTACTCAAATTTTGCCAGTTGTTCCAAT
 961 AATGTCCTTTATAGCAAAAGAGCAGAAAAACTTTTTTTTCTGGTCTAGGATCTAATCCATGATCTCACATTGCATTTACT
1041 TGTCATATCTATCAGAAGTCACTTGACATCAGTTTGTCCCATTATTGCTGATGGTATTTTAATCACTTTTTGAGGTGGTG
1121 CCTGTCAGGTTATTGTAAAGTTACTATTTTTACTTTATAATTAACAAGTATATTTGGAGGAGATAATTTGAGATGATGTA
1201 AAAATCCTCTTTCTCATCAAACTTTCTACTAGTTTTAGCATCTATCAGTGATTCATGACTGAATCAGTTATTACAGTGAT
1281 GGTTGTCAAATGGTGATTTTCTAATTCCATCATCCATTCTGTATTTATCAGTTGGCATTCTATTATAAGAAGGTGCGGGC
1361 CGGGGCGGTGGCTCACGCCTGTAATCCCATCACTTTGGGAGGCTGAGGTGGGCGGATCACATGAGACCAAGTTTGAGACC
1441 AGCCTGGCCAACATGGCGAAACCCCATCTCTACTGAAAATACAAAAAATCAGCCGGGCATGGTGGCATACACTTGTAATC
1521 TCGGCTGCTCGGGAGTCTGAGGCAGGAGAATCTCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCATGCCACT
1601 GCACTCCAGCCTGGGCGACAAAGTGAGACTCCATCTCAGAAAAAAAAGTGCTTTCCCTTCTCTCTTATTTATTTATTCAT
1681 ACCAGTATGCACTCATGGATTCTTATTTTAGTCAATGAGTTATAATCTGTCACTGTCATTATTTAATATGTTGCTTTTAA
1761 AATAGTATATGAAATAATAAAACTGTAACAGTAAATGGTTATTAGATTGCTTACCTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uuuagggUAGGGGUCCUUGGGg 5'
                 |||:|:  |||||| 
Target 5' caggagaATCTCT-TGAACCCa 3'
1543 - 1563 122.00 -14.60
2
miRNA  3' uuuaggguaggggucCUUGGGg 5'
                         |||||| 
Target 5' gcaggagaatcgcttGAACCCa 3'
759 - 780 120.00 -12.90
3
miRNA  3' uuUAGGGU--AGGGGUCCUUGGGg 5'
            |||:|:  | |:|:|||::|: 
Target 5' taATCTCGGCTGCTCGGGAGTCTg 3'
1516 - 1539 118.00 -20.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM8850459 4 COSMIC
COSN31576607 19 COSMIC
COSN30184155 22 COSMIC
COSN31900115 24 COSMIC
COSN30166218 29 COSMIC
COSN26982114 33 COSMIC
COSN1681916 61 COSMIC
COSN31583703 72 COSMIC
COSN30107373 94 COSMIC
COSN29802587 832 COSMIC
COSN26811819 1362 COSMIC
COSN8175615 1617 COSMIC
COSN6277792 1737 COSMIC
rs2652822 920 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1234705297 8 dbSNP
rs776186091 9 dbSNP
rs747659368 10 dbSNP
rs1203092532 13 dbSNP
rs769268890 15 dbSNP
rs1261297503 17 dbSNP
rs1466262659 18 dbSNP
rs772952781 20 dbSNP
rs371618594 21 dbSNP
rs767978346 30 dbSNP
rs776131331 31 dbSNP
rs761331959 32 dbSNP
rs200705826 33 dbSNP
rs757380943 34 dbSNP
rs1414857850 41 dbSNP
rs765336354 44 dbSNP
rs1213438509 61 dbSNP
rs934006078 66 dbSNP
rs1251475711 70 dbSNP
rs1466883337 72 dbSNP
rs963619078 72 dbSNP
rs1041730590 76 dbSNP
rs1195040290 84 dbSNP
rs944760416 94 dbSNP
rs879115889 100 dbSNP
rs1335974286 118 dbSNP
rs779091674 120 dbSNP
rs1309411659 126 dbSNP
rs1427398228 133 dbSNP
rs1369365028 135 dbSNP
rs1168317536 151 dbSNP
rs557318270 168 dbSNP
rs1023753021 169 dbSNP
rs755379997 175 dbSNP
rs902469828 192 dbSNP
rs765621335 194 dbSNP
rs1032185796 206 dbSNP
rs530784811 207 dbSNP
rs1470669514 208 dbSNP
rs893604764 212 dbSNP
rs1374692970 231 dbSNP
rs111821958 243 dbSNP
rs577522847 245 dbSNP
rs1163973909 247 dbSNP
rs1222272588 249 dbSNP
rs191740466 251 dbSNP
rs1023829168 253 dbSNP
rs1329521992 259 dbSNP
rs970439129 259 dbSNP
rs1289872480 269 dbSNP
rs1226142370 273 dbSNP
rs1349392711 280 dbSNP
rs567820626 281 dbSNP
rs981776914 283 dbSNP
rs1025223634 284 dbSNP
rs539953669 298 dbSNP
rs553285225 302 dbSNP
rs1361428370 307 dbSNP
rs1414595045 308 dbSNP
rs571364366 316 dbSNP
rs371920917 317 dbSNP
rs199934528 323 dbSNP
rs1192984989 326 dbSNP
rs1489455444 334 dbSNP
rs1244915920 335 dbSNP
rs922412328 337 dbSNP
rs760627566 340 dbSNP
rs182378934 342 dbSNP
rs1271666205 343 dbSNP
rs922714356 365 dbSNP
rs934058457 370 dbSNP
rs777859813 378 dbSNP
rs746952785 386 dbSNP
rs935278243 389 dbSNP
rs1432046744 392 dbSNP
rs1391344912 394 dbSNP
rs1485281829 402 dbSNP
rs757260172 402 dbSNP
rs1456973667 404 dbSNP
rs1184234953 411 dbSNP
rs1178426248 418 dbSNP
rs1054091183 421 dbSNP
rs575335754 425 dbSNP
rs1012474119 431 dbSNP
rs1012523084 435 dbSNP
rs1023418170 441 dbSNP
rs187869211 443 dbSNP
rs1415407112 445 dbSNP
rs1003211542 447 dbSNP
rs554859093 450 dbSNP
rs956772403 468 dbSNP
rs1309956869 499 dbSNP
rs989871343 501 dbSNP
rs951095095 503 dbSNP
rs1367966487 504 dbSNP
rs983785473 509 dbSNP
rs1434840536 510 dbSNP
rs975278635 513 dbSNP
rs1290746877 519 dbSNP
rs922446744 520 dbSNP
rs1017631424 521 dbSNP
rs139740798 524 dbSNP
rs376585578 527 dbSNP
rs1291965862 532 dbSNP
rs908270707 540 dbSNP
rs1430395661 549 dbSNP
rs941063449 554 dbSNP
rs564916437 557 dbSNP
rs144440329 559 dbSNP
rs1186524923 566 dbSNP
rs1448674766 568 dbSNP
rs1256532895 570 dbSNP
rs955450632 573 dbSNP
rs376807695 574 dbSNP
rs745722488 577 dbSNP
rs1254969192 587 dbSNP
rs977476471 589 dbSNP
rs73444395 590 dbSNP
rs1213162716 594 dbSNP
rs1287542034 601 dbSNP
rs1228253267 602 dbSNP
rs936025962 606 dbSNP
rs1315241147 607 dbSNP
rs775131854 608 dbSNP
rs1054448014 609 dbSNP
rs1045309543 610 dbSNP
rs1210145367 612 dbSNP
rs1308804742 614 dbSNP
rs1411748729 615 dbSNP
rs113265850 617 dbSNP
rs748887698 618 dbSNP
rs947996401 619 dbSNP
rs1182259521 622 dbSNP
rs1044882743 624 dbSNP
rs1166638888 631 dbSNP
rs192500968 638 dbSNP
rs1160625285 649 dbSNP
rs549058999 650 dbSNP
rs1182366169 655 dbSNP
rs1010962994 666 dbSNP
rs1022271881 672 dbSNP
rs963975485 680 dbSNP
rs996751972 685 dbSNP
rs1434181042 692 dbSNP
rs185649160 695 dbSNP
rs1321431335 699 dbSNP
rs528768067 700 dbSNP
rs190520918 701 dbSNP
rs1005662334 709 dbSNP
rs1016596054 714 dbSNP
rs1307465638 717 dbSNP
rs1390816937 719 dbSNP
rs908339672 722 dbSNP
rs1221727933 724 dbSNP
rs964646613 725 dbSNP
rs1416838112 727 dbSNP
rs996788185 728 dbSNP
rs1353878879 734 dbSNP
rs1159510019 741 dbSNP
rs571849551 742 dbSNP
rs1232902377 743 dbSNP
rs761202724 746 dbSNP
rs1444095880 747 dbSNP
rs1451624479 748 dbSNP
rs539209315 751 dbSNP
rs1210647831 768 dbSNP
rs1208538445 770 dbSNP
rs766966179 771 dbSNP
rs915586600 772 dbSNP
rs1479530330 780 dbSNP
rs117074183 788 dbSNP
rs955503717 792 dbSNP
rs1287874906 795 dbSNP
rs1238991570 796 dbSNP
rs1234072021 803 dbSNP
rs977570952 809 dbSNP
rs568933922 810 dbSNP
rs924718855 811 dbSNP
rs1393511401 813 dbSNP
rs192067117 814 dbSNP
rs1458541318 819 dbSNP
rs1386021110 821 dbSNP
rs1157566884 822 dbSNP
rs184613743 827 dbSNP
rs139120249 830 dbSNP
rs915875417 832 dbSNP
rs947978446 833 dbSNP
rs1170291668 834 dbSNP
rs1044935902 836 dbSNP
rs1190889178 841 dbSNP
rs1353180233 842 dbSNP
rs68054050 843 dbSNP
rs1332996040 847 dbSNP
rs1377214395 849 dbSNP
rs188547979 850 dbSNP
rs1436867806 854 dbSNP
rs1231065800 857 dbSNP
rs1370140802 860 dbSNP
rs888346378 861 dbSNP
rs1011411380 862 dbSNP
rs1170289637 862 dbSNP
rs142946511 862 dbSNP
rs1491073548 862 dbSNP
rs201338310 862 dbSNP
rs34509023 862 dbSNP
rs765672600 862 dbSNP
rs867323854 863 dbSNP
rs1448077460 868 dbSNP
rs201472257 870 dbSNP
rs190235801 871 dbSNP
rs201227866 871 dbSNP
rs1043780652 872 dbSNP
rs56399509 873 dbSNP
rs1005260698 874 dbSNP
rs1258409838 874 dbSNP
rs1448383142 875 dbSNP
rs1341875072 876 dbSNP
rs1366354688 882 dbSNP
rs182846531 883 dbSNP
rs1191905369 885 dbSNP
rs1248541687 886 dbSNP
rs1038450770 887 dbSNP
rs1478388868 895 dbSNP
rs1186512218 896 dbSNP
rs1417952578 897 dbSNP
rs1370591292 900 dbSNP
rs899470801 900 dbSNP
rs899882314 903 dbSNP
rs996784509 906 dbSNP
rs1029562777 908 dbSNP
rs955482441 910 dbSNP
rs1164187129 915 dbSNP
rs2652822 920 dbSNP
rs1015844295 923 dbSNP
rs1187450215 928 dbSNP
rs1394121333 934 dbSNP
rs750131481 936 dbSNP
rs1029945427 937 dbSNP
rs752989962 938 dbSNP
rs372242227 947 dbSNP
rs955597886 950 dbSNP
rs1207254713 952 dbSNP
rs962539859 955 dbSNP
rs999058684 957 dbSNP
rs9788649 965 dbSNP
rs1358121001 973 dbSNP
rs1282100352 974 dbSNP
rs1232248609 975 dbSNP
rs957689185 979 dbSNP
rs1350623632 991 dbSNP
rs915663357 992 dbSNP
rs1332392119 995 dbSNP
rs1354480327 999 dbSNP
rs1436539194 1000 dbSNP
rs969737641 1006 dbSNP
rs1388969144 1008 dbSNP
rs1164546507 1011 dbSNP
rs981092669 1015 dbSNP
rs764193654 1018 dbSNP
rs990220265 1030 dbSNP
rs112492528 1043 dbSNP
rs118066038 1045 dbSNP
rs1222164747 1052 dbSNP
rs575328436 1053 dbSNP
rs1271012091 1068 dbSNP
rs1212725379 1074 dbSNP
rs1329411695 1079 dbSNP
rs1289771289 1095 dbSNP
rs970054938 1121 dbSNP
rs981395001 1125 dbSNP
rs927917483 1147 dbSNP
rs181310525 1183 dbSNP
rs149901777 1185 dbSNP
rs116900717 1193 dbSNP
rs1212118488 1197 dbSNP
rs1052662671 1205 dbSNP
rs1348547261 1214 dbSNP
rs1325642561 1235 dbSNP
rs1276595872 1236 dbSNP
rs547002333 1241 dbSNP
rs1292286277 1245 dbSNP
rs1458016336 1257 dbSNP
rs1452293927 1263 dbSNP
rs1391120014 1272 dbSNP
rs1157127447 1277 dbSNP
rs545888435 1293 dbSNP
rs914065882 1308 dbSNP
rs373266214 1310 dbSNP
rs1240391772 1319 dbSNP
rs1479092352 1322 dbSNP
rs1191746671 1324 dbSNP
rs1478950198 1338 dbSNP
rs368392011 1341 dbSNP
rs1465127900 1345 dbSNP
rs1038101648 1354 dbSNP
rs565546024 1356 dbSNP
rs751713578 1357 dbSNP
rs532764768 1362 dbSNP
rs1050741910 1363 dbSNP
rs1221500853 1366 dbSNP
rs551150010 1367 dbSNP
rs1004543582 1368 dbSNP
rs891423691 1375 dbSNP
rs1317055958 1377 dbSNP
rs1357992696 1378 dbSNP
rs569020509 1380 dbSNP
rs535955788 1382 dbSNP
rs1359856845 1383 dbSNP
rs1178318354 1393 dbSNP
rs1412777249 1398 dbSNP
rs1393200631 1399 dbSNP
rs1401776341 1410 dbSNP
rs1278750046 1414 dbSNP
rs7162715 1415 dbSNP
rs898362942 1416 dbSNP
rs1485339940 1422 dbSNP
rs1286222445 1423 dbSNP
rs117973093 1429 dbSNP
rs1022750587 1430 dbSNP
rs1223366505 1436 dbSNP
rs1280273057 1440 dbSNP
rs781261778 1444 dbSNP
rs893280173 1449 dbSNP
rs751937496 1452 dbSNP
rs565283406 1453 dbSNP
rs1381931419 1454 dbSNP
rs970107330 1457 dbSNP
rs1218076792 1458 dbSNP
rs1257399770 1459 dbSNP
rs1484925370 1472 dbSNP
rs1374878317 1474 dbSNP
rs981445674 1478 dbSNP
rs1430301896 1481 dbSNP
rs1391859372 1484 dbSNP
rs1190077835 1489 dbSNP
rs1035769116 1493 dbSNP
rs558397229 1495 dbSNP
rs1472923420 1496 dbSNP
rs144925121 1500 dbSNP
rs558437410 1504 dbSNP
rs1256165693 1512 dbSNP
rs1206552431 1521 dbSNP
rs1484319149 1522 dbSNP
rs908391791 1523 dbSNP
rs1227159849 1524 dbSNP
rs914138046 1531 dbSNP
rs755922637 1532 dbSNP
rs779779650 1534 dbSNP
rs1394165477 1536 dbSNP
rs1410421165 1542 dbSNP
rs932740608 1545 dbSNP
rs1340788508 1574 dbSNP
rs755498985 1575 dbSNP
rs1350198108 1579 dbSNP
rs1288114776 1581 dbSNP
rs1307343020 1588 dbSNP
rs932388192 1590 dbSNP
rs1416613724 1595 dbSNP
rs372000762 1597 dbSNP
rs11635238 1599 dbSNP
rs1182250069 1600 dbSNP
rs576679061 1604 dbSNP
rs573601203 1617 dbSNP
rs1249076834 1618 dbSNP
rs1050752084 1633 dbSNP
rs768401296 1635 dbSNP
rs891153474 1640 dbSNP
rs1267576914 1658 dbSNP
rs537693850 1660 dbSNP
rs1289161417 1661 dbSNP
rs199541205 1663 dbSNP
rs768892470 1665 dbSNP
rs1257313311 1669 dbSNP
rs890762018 1674 dbSNP
rs934917842 1679 dbSNP
rs1053395892 1683 dbSNP
rs893364599 1684 dbSNP
rs555928101 1686 dbSNP
rs898400699 1694 dbSNP
rs542771024 1699 dbSNP
rs1393293640 1700 dbSNP
rs781564222 1703 dbSNP
rs781632481 1714 dbSNP
rs575365863 1717 dbSNP
rs1158746858 1718 dbSNP
rs1393887610 1719 dbSNP
rs1464496971 1725 dbSNP
rs1434254617 1732 dbSNP
rs527659456 1734 dbSNP
rs1192166863 1740 dbSNP
rs542736581 1742 dbSNP
rs950697570 1743 dbSNP
rs1269039726 1747 dbSNP
rs771416834 1750 dbSNP
rs1002633385 1757 dbSNP
rs1260186693 1761 dbSNP
rs1238323851 1766 dbSNP
rs149033546 1771 dbSNP
rs1305459604 1786 dbSNP
rs1438482964 1800 dbSNP
rs1369910170 1811 dbSNP
rs1035439124 1814 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084041. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep1 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uuuagGGUAGGGGUCCUUGGGg 5'
               |||  | |:|||: |: 
Target 5' -----CCA--CGCGGGAGGCUg 3'
1 - 15
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084041
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep1
Location of target site ENST00000413507.2 | 3UTR | CCACGCGGGAGGCUGAGGCAGGAGAAUCGCUUGAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.522 4.4e-3 0.582 1.4e-3 24 Click to see details
GSE32688 Pancreatic cancer -0.453 4.6e-3 -0.447 5.2e-3 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.549 6.1e-3 0.641 1.2e-3 20 Click to see details
GSE19783 ER+ ER+ breast cancer -0.275 1.2e-1 -0.353 6.3e-2 20 Click to see details
GSE28260 Renal cortex and medulla -0.321 1.4e-1 -0.418 7.8e-2 13 Click to see details
GSE21032 Prostate cancer 0.107 1.7e-1 0.136 1.1e-1 83 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.363 1.7e-1 0.350 1.8e-1 9 Click to see details
GSE19783 ER- ER- breast cancer -0.1 1.9e-1 -0.155 8.6e-2 79 Click to see details
GSE19350 CNS germ cell tumors -0.173 3.0e-1 -0.292 1.8e-1 12 Click to see details
GSE21687 Ependynoma primary tumors 0.063 3.1e-1 0.131 1.5e-1 64 Click to see details
GSE19536 Breast cancer -0.047 3.2e-1 -0.165 5.0e-2 100 Click to see details
GSE26953 Aortic valvular endothelial cells -0.063 3.8e-1 -0.125 2.8e-1 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.05 4.1e-1 0.047 4.1e-1 25 Click to see details
GSE42095 Differentiated embryonic stem cells 0.036 4.4e-1 -0.184 2.0e-1 23 Click to see details
GSE38226 Liver fibrosis 0.018 4.7e-1 0.021 4.6e-1 21 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.011 4.8e-1 -0.042 4.2e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA 0.26 0.02 0.246 0.03 59 Click to see details
ESCA 0.606 0.02 0.591 0.03 11 Click to see details
HNSC -0.281 0.04 -0.298 0.03 40 Click to see details
STAD 0.328 0.04 0.319 0.05 28 Click to see details
KIRP 0.302 0.05 0.344 0.03 32 Click to see details
CHOL 0.617 0.05 0.619 0.05 8 Click to see details
BLCA 0.38 0.07 0.400 0.06 16 Click to see details
BRCA 0.111 0.17 0.158 0.08 78 Click to see details
PCPG 0.864 0.17 1.000 0.5 3 Click to see details
CESC -0.795 0.21 -1.000 0.5 3 Click to see details
KICH 0.186 0.22 0.253 0.14 20 Click to see details
LIHC 0.092 0.29 0.103 0.27 38 Click to see details
UCEC -0.133 0.29 -0.242 0.16 19 Click to see details
KIRC -0.053 0.34 -0.050 0.35 62 Click to see details
LUAD 0.116 0.38 0.100 0.4 9 Click to see details
PRAD -0.073 0.38 -0.372 0.06 19 Click to see details
LUSC -0.04 0.41 -0.058 0.36 38 Click to see details
COAD 0.063 0.44 -0.143 0.37 8 Click to see details
PAAD -0.025 0.49 0.400 0.3 4 Click to see details
PAAD -0.025 0.49 0.400 0.3 4 Click to see details
PAAD -0.025 0.49 0.400 0.3 4 Click to see details
131 hsa-miR-23a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038958 ATF1 activating transcription factor 1 1 1
MIRT057661 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT395438 NFKBID NFKB inhibitor delta 2 2
MIRT463884 WNT7B Wnt family member 7B 2 4
MIRT475804 HDGF heparin binding growth factor 2 2
MIRT478528 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT479278 CHD4 chromodomain helicase DNA binding protein 4 2 6
MIRT492564 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT500353 ZNF385A zinc finger protein 385A 2 2
MIRT509788 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT511566 HIST3H2BB histone cluster 3 H2B family member b 2 4
MIRT525450 GPATCH2L G-patch domain containing 2 like 2 2
MIRT539558 CNKSR3 CNKSR family member 3 2 4
MIRT540034 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT540225 SAMD5 sterile alpha motif domain containing 5 2 2
MIRT540242 RGS17 regulator of G protein signaling 17 2 2
MIRT540871 ZBTB24 zinc finger and BTB domain containing 24 2 2
MIRT559065 C19orf47 chromosome 19 open reading frame 47 2 4
MIRT560685 HIST1H1T histone cluster 1 H1 family member t 2 2
MIRT565593 SLC35G1 solute carrier family 35 member G1 2 2
MIRT565642 SKI SKI proto-oncogene 2 2
MIRT576747 Tmem127 transmembrane protein 127 2 2
MIRT607712 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT615682 NAV2 neuron navigator 2 2 2
MIRT617337 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT617378 FAM227A family with sequence similarity 227 member A 2 2
MIRT620855 SERPING1 serpin family G member 1 2 2
MIRT625112 SLC1A5 solute carrier family 1 member 5 2 2
MIRT625124 NUP93 nucleoporin 93 2 2
MIRT625898 LINC00632 long intergenic non-protein coding RNA 632 2 2
MIRT626016 XRCC2 X-ray repair cross complementing 2 2 2
MIRT626481 ADAT1 adenosine deaminase, tRNA specific 1 2 2
MIRT626573 MED7 mediator complex subunit 7 2 2
MIRT626814 PRR11 proline rich 11 2 2
MIRT628136 HM13 histocompatibility minor 13 2 2
MIRT630771 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT633133 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT636950 APTX aprataxin 2 2
MIRT637802 GGPS1 geranylgeranyl diphosphate synthase 1 2 2
MIRT638622 GSR glutathione-disulfide reductase 2 4
MIRT642196 SMAGP small cell adhesion glycoprotein 2 2
MIRT645121 HES2 hes family bHLH transcription factor 2 2 2
MIRT645344 AGTPBP1 ATP/GTP binding protein 1 2 2
MIRT646564 ALDH5A1 aldehyde dehydrogenase 5 family member A1 2 2
MIRT649243 TRIM65 tripartite motif containing 65 2 2
MIRT651810 USP49 ubiquitin specific peptidase 49 2 2
MIRT652137 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT652668 TIMELESS timeless circadian clock 2 2
MIRT655894 NEK9 NIMA related kinase 9 2 2
MIRT656564 LYRM7 LYR motif containing 7 2 2
MIRT657194 IKZF3 IKAROS family zinc finger 3 2 2
MIRT657907 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT660207 BMPR1A bone morphogenetic protein receptor type 1A 2 2
MIRT660619 ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2 2
MIRT660826 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT660986 ABHD2 abhydrolase domain containing 2 2 2
MIRT662232 PGBD4 piggyBac transposable element derived 4 2 2
MIRT663691 ZNF347 zinc finger protein 347 2 2
MIRT665577 TUBD1 tubulin delta 1 2 2
MIRT666149 SP2 Sp2 transcription factor 2 2
MIRT666310 SLC22A3 solute carrier family 22 member 3 2 2
MIRT666457 SCRG1 stimulator of chondrogenesis 1 2 2
MIRT667716 KIAA1468 KIAA1468 2 2
MIRT668329 FKBP5 FK506 binding protein 5 2 2
MIRT668370 FBXO47 F-box protein 47 2 2
MIRT669304 C17orf75 chromosome 17 open reading frame 75 2 2
MIRT669538 ALG9 ALG9, alpha-1,2-mannosyltransferase 2 2
MIRT671681 ADK adenosine kinase 2 2
MIRT672177 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT673604 HPSE heparanase 2 2
MIRT673749 ZNF333 zinc finger protein 333 2 2
MIRT674807 FAM229B family with sequence similarity 229 member B 2 2
MIRT675286 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT675391 SVOP SV2 related protein 2 2
MIRT675788 MED28 mediator complex subunit 28 2 2
MIRT676151 OGFOD1 2-oxoglutarate and iron dependent oxygenase domain containing 1 2 2
MIRT676499 GJD3 gap junction protein delta 3 2 2
MIRT676621 CSNK1E casein kinase 1 epsilon 2 2
MIRT676644 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT676711 METTL14 methyltransferase like 14 2 2
MIRT676809 SHROOM4 shroom family member 4 2 2
MIRT677036 FOXO3 forkhead box O3 2 2
MIRT677062 NT5C2 5'-nucleotidase, cytosolic II 2 2
MIRT677086 SMIM15 small integral membrane protein 15 2 2
MIRT677193 MURC caveolae associated protein 4 2 2
MIRT677273 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT677345 POC1A POC1 centriolar protein A 2 2
MIRT677504 SLC10A6 solute carrier family 10 member 6 2 2
MIRT677526 OCIAD2 OCIA domain containing 2 2 2
MIRT677661 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT677727 SSR1 signal sequence receptor subunit 1 2 2
MIRT677803 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT678144 SLC4A4 solute carrier family 4 member 4 2 2
MIRT678376 VTA1 vesicle trafficking 1 2 2
MIRT678708 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT678868 FAM118A family with sequence similarity 118 member A 2 2
MIRT679039 LACTB lactamase beta 2 2
MIRT679081 PURB purine rich element binding protein B 2 2
MIRT679137 SYK spleen associated tyrosine kinase 2 2
MIRT679299 SSBP2 single stranded DNA binding protein 2 2 2
MIRT679741 CABP4 calcium binding protein 4 2 2
MIRT679946 AS3MT arsenite methyltransferase 2 2
MIRT679976 E2F2 E2F transcription factor 2 2 2
MIRT683628 MTO1 mitochondrial tRNA translation optimization 1 2 2
MIRT683901 PSMB9 proteasome subunit beta 9 2 2
MIRT684172 MOG myelin oligodendrocyte glycoprotein 2 2
MIRT684231 C20orf144 chromosome 20 open reading frame 144 2 2
MIRT685403 C1orf158 chromosome 1 open reading frame 158 2 2
MIRT686253 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT687513 NCKAP1 NCK associated protein 1 2 2
MIRT688243 FITM2 fat storage inducing transmembrane protein 2 2 2
MIRT688315 FAM151B family with sequence similarity 151 member B 2 2
MIRT688733 CNDP1 carnosine dipeptidase 1 2 2
MIRT689031 ANGPTL3 angiopoietin like 3 2 2
MIRT698207 TMEM248 transmembrane protein 248 2 2
MIRT699859 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT709954 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT711541 MSH3 mutS homolog 3 2 2
MIRT712077 WDR37 WD repeat domain 37 2 2
MIRT715312 POLR2E RNA polymerase II subunit E 2 2
MIRT715725 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT715748 HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like 2 2
MIRT717604 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT717875 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT718042 NIPAL2 NIPA like domain containing 2 2 2
MIRT718829 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT724037 CAMK2N2 calcium/calmodulin dependent protein kinase II inhibitor 2 2 2
MIRT733305 TNF tumor necrosis factor 1 0
MIRT734941 HSPA1B heat shock protein family A (Hsp70) member 1B 3 0
MIRT737343 IGF2 insulin like growth factor 2 3 0
MIRT737546 PTEN phosphatase and tensin homolog 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-23a 1'-Acetoxychavicol acetate (ACA) NULL 119104 Microarray HN4 cell line 24317043 2014 down-regulated
miR-23a 5-Fluorouracil approved 3385 Quantitative real-time PCR colon cancer cells 17702597 2007 up-regulated
miR-23a Curcumin NULL 969516 Microarray BxPC-3 human pancreatic carcinoma cell line 18347134 2008 up-regulated
miR-23a Enoxacin approved 3229 Quantitative real-time PCR HEK293 cells 18641635 2008 up-regulated
miR-23a 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR endometrial stromal 19088369 2008 down-regulated
miR-23a 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR glandular epithelial cells 19088369 2008 down-regulated
miR-23a Medroxyprogesterone acetate approved 6279 Quantitative real-time PCR endometrial stromal 19088369 2008 down-regulated
miR-23a Medroxyprogesterone acetate approved 6279 Quantitative real-time PCR glandular epithelial cells 19088369 2008 up-regulated
miR-23a 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
miR-23a Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miR-23a Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-23a Bio-Oss NULL NULL Microarray osteoblast-like cell line (MG63) 20224834 2010 up-regulated
miR-23a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-23a 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 up-regulated
miR-23a Trastuzumab approved NULL Microarray BT474 cells 22384020 2012 up-regulated
miR-23a Trastuzumab approved NULL Microarray SKBR3 cells. 22384020 2012 up-regulated
miR-23a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Quantitative real-time PCR thymus 23024791 2012 down-regulated
miR-23a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-23a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 up-regulated
miR-23a Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 up-regualted
miR-23a Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
miR-23a Comfrey NULL 6440495 Microarray rat liver 21370286 2011 up-regulated
miR-23a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-23a Ethanol NULL 702 Quantitative real-time PCR zebrafish embryos 22298809 2012 down-regulated
miR-23a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 up-regulated
miR-23a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 up-regulated
miR-23a Morphine approved 5288826 Microarray human monocyte-derived macrophages (h-mdms) infection with HIV-1 20564181 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive Low Breast Cancer cell line (MDA-MB-231)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (BGC823)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC-7901)
hsa-mir-23a Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-mir-23a Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-23a Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive cell line (OE19)
hsa-mir-23a Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-23a Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive cell line (SGC-7901)
hsa-miR-23a-5p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-23a-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-23a-5p Palbociclib 5330286 NSC758247 approved resistant High Breast Cancer cell line (T47D)
hsa-miR-23a-5p Arsenic trioxide 261004 NSC759274 approved sensitive Low Acute Myeloid Leukemia cell line (U937, Kasumi-1, THP-1, Jurkat E6.1, SUP B15)
hsa-miR-23a-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-23a-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-23a-5p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-23a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-23a-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-23a-5p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-23a-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-23a-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-23a-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-23a-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-23a-5p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-23a-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (MDA-231)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-23a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-23a-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-23a-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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