pre-miRNA Information
pre-miRNA hsa-mir-125b-2   
Genomic Coordinates chr21: 16590237 - 16590325
Synonyms MIRN125B2, MIR125B2
Description Homo sapiens miR-125b-2 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-125b-2-3p
Sequence 54| UCACAAGUCAGGCUCUUGGGAC |75
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 21 + 16590292 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs575583557 6 dbSNP
rs1331783293 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol THAP1   
Synonyms DYT6
Description THAP domain containing 1
Transcript NM_199003   
Other Transcripts NM_018105   
Expression
Putative miRNA Targets on THAP1
3'UTR of THAP1
(miRNA target sites are highlighted)
>THAP1|NM_199003|3'UTR
   1 TGCCGCCTCTTCAGACCCCTGTTAATCTCTCAGTTTTCTGTGACCACAACTATACTGTGGAGGATACAATGCACCAGCGG
  81 AAAAGGATTCATCAGCTAGAACAGCAAGTTGAAAAACTCAGAAAGAAGCTCAAGACCGCACAGCAGCGATGCAGAAGGCA
 161 AGAACGGCAGCTTGAAAAATTAAAGGAGGTTGTTCACTTCCAGAAAGAGAAAGACGACGTATCAGAAAGAGGTTATGTGA
 241 TTCTACCAAATGACTACTTTGAAATAGTTGAAGTACCAGCATAAAAAAATGAAATGTGTATTGATTTCTAATGGGGCAAT
 321 ACCACATATCCTCCTCTAGCCTGTAAAGGAGTTTCATTTAAAAAAATAACATTTGATTACTTATATAAAAACAGTTCAGA
 401 ATATTTTTTTAAAAAAAATTCTATATATACTGTAAAATTATAAATTTTTTTGTTTGTAATTTCAGGTTTTTTACATTTTA
 481 ACAAAATATTTTAAAAGTTATAAACTAACCTCAGACCTCTAATGTAAGTTGGTTTCAAGATTGGGGATTTTGGGGTTTTT
 561 TTTTAGTATTTATAGAAATAATGTAAAAATAAAAAGTAAAGAGAATGAGAACAGTGTGGTAAAAGGGTGATTTCAGTTTA
 641 AAACTTAAAATTAGTACTGTTTTATTGAGAGAATTTAGTTATATTTTAAATCAGAAGTATGGGTCAGATCATGGGACATA
 721 ACTTCTTAGAATATATATATACATATGTACATATTCTCATATGTAAAGTCACAAGGTTCATTTATCTTTCTGAATCAGTT
 801 ATCAAAGATAAATTGGCAAGTCAGTACTTAAGAAAAAAGATTTGATTATCATCACAGCAGAAAAAAGTCATTGCATATCT
 881 GATCAATAACTTCAGATTCTAAGAGTGGATTTTTTTTTTTTACATGGGCTCCTATTTTTTCCCCTACTGTCTTGCATTAT
 961 AAAATTAGAAGTGTATTTTCAGTGGAAGAAACATTTTTCAATAAATAAAGTAAGGCATTGTCATCAATGAAGTAATTAAA
1041 ACTGGGACCTGATCTATGATACGCTTTTTTCTTTCATTACACCCTAGCTGAAGGACATCCAGTTCCCCAGCTGTAGTTAT
1121 GTATCTGCCTTCAAGTCTCTGACAAATGTGCTGTGTTAGTAGAGTTTGATTTGTATCATATGATAATCTTGCACTTGACT
1201 GAGTTGGGACAAGGCTTCACATAAAAAATTATTTCTTCACTTTTAACACAAGTTAGAAATTATATCCCATTTAGTTAAAT
1281 GCGTGATTTATATTCAGAACAACCTACTATGTAGCGTTTATTTTACTGAATGTGGAGATTTAAACACTGAGGTTTCTGTT
1361 CAAACTGTGAGTTCTGTTCTTTGTGAGAAATTTTACATATATTGGAAGTGAAAATATGTTCTGAGTAAACAAATATTGCT
1441 ATGGGAGTTATCTTTTTAGATTTAGAATAACTGTTCCAATGATAATTATTACTTTTATATTTCAAAGTACACTAAGATCG
1521 TTGAAGAGCAATAGAACCTTTAAGACAGTATTAAAGGTGTGAAACAATGGCAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' caggguUCUCGGACUGAACAcu 5'
                ||||::|||:||||  
Target 5' gttagtAGAGTTTGATTTGTat 3'
1155 - 1176 136.00 -16.50
2
miRNA  3' caggguucUCGGAC-UGAACacu 5'
                  | |:|| |||||   
Target 5' atatgataATCTTGCACTTGact 3'
1178 - 1200 110.00 -7.20
3
miRNA  3' cagGGUUCUC-GGAC--UGAACACu 5'
             |:: ||| :|||   :||||| 
Target 5' aaaCTGTGAGTTCTGTTCTTTGTGa 3'
1362 - 1386 109.00 -14.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
463444 5 ClinVar
547035 7 ClinVar
965170 29 ClinVar
1649 32 ClinVar
871563 33 ClinVar
931879 42 ClinVar
863325 45 ClinVar
448685 63 ClinVar
225489 69 ClinVar
1061415 85 ClinVar
1647 103 ClinVar
1650 117 ClinVar
1069320 128 ClinVar
363125 131 ClinVar
429366 147 ClinVar
586832 147 ClinVar
521683 148 ClinVar
1165509 179 ClinVar
1113391 200 ClinVar
444749 216 ClinVar
463445 219 ClinVar
448686 232 ClinVar
695720 243 ClinVar
911595 349 ClinVar
363124 404 ClinVar
911594 410 ClinVar
363123 411 ClinVar
363122 419 ClinVar
911593 421 ClinVar
911592 423 ClinVar
363121 425 ClinVar
910381 440 ClinVar
363120 474 ClinVar
363119 529 ClinVar
363118 565 ClinVar
363117 581 ClinVar
363116 718 ClinVar
363115 739 ClinVar
363114 743 ClinVar
910380 882 ClinVar
363113 970 ClinVar
363112 1029 ClinVar
909434 1061 ClinVar
909433 1079 ClinVar
363111 1087 ClinVar
909432 1119 ClinVar
909431 1161 ClinVar
363110 1283 ClinVar
363109 1316 ClinVar
908574 1422 ClinVar
363108 1441 ClinVar
363107 1519 ClinVar
363106 1534 ClinVar
COSM164893 5 COSMIC
COSM3900322 12 COSMIC
COSM750307 14 COSMIC
COSM8596197 15 COSMIC
COSM3834758 17 COSMIC
COSM6837243 21 COSMIC
COSM9829057 22 COSMIC
COSM4826049 29 COSMIC
COSM5884711 40 COSMIC
COSM339253 41 COSMIC
COSM9829056 50 COSMIC
COSM9635493 52 COSMIC
COSM8679784 60 COSMIC
COSM1100075 76 COSMIC
COSM9829055 88 COSMIC
COSM9224755 91 COSMIC
COSM9829054 91 COSMIC
COSM6530393 92 COSMIC
COSM1100074 104 COSMIC
COSM9685643 109 COSMIC
COSM6479147 137 COSMIC
COSM1100073 147 COSMIC
COSM6489754 154 COSMIC
COSM7532599 155 COSMIC
COSM9829053 155 COSMIC
COSM7319217 157 COSMIC
COSM9010132 165 COSMIC
COSM6113330 166 COSMIC
COSM9829052 182 COSMIC
COSM223251 186 COSMIC
COSM3834757 187 COSMIC
COSM9829051 205 COSMIC
COSM4733480 215 COSMIC
COSM4733479 216 COSMIC
COSM4986363 217 COSMIC
COSM8798337 217 COSMIC
COSM9829050 220 COSMIC
COSM6496572 225 COSMIC
COSM9691496 258 COSMIC
COSM323807 277 COSMIC
COSM1457191 279 COSMIC
COSN26998481 283 COSMIC
COSN29410242 289 COSMIC
COSN8085258 298 COSMIC
COSN30166482 303 COSMIC
COSN9635634 348 COSMIC
COSN505771 371 COSMIC
COSN30530101 396 COSMIC
COSN30146629 400 COSMIC
COSN14344441 410 COSMIC
COSN14344436 411 COSMIC
COSN30133297 422 COSMIC
COSN28710259 463 COSMIC
COSN30166652 546 COSMIC
COSN17745168 555 COSMIC
COSN30173603 555 COSMIC
COSN20486899 556 COSMIC
COSN30543841 564 COSMIC
COSN31484197 603 COSMIC
COSN31577691 742 COSMIC
COSN6696051 870 COSMIC
COSN27498969 910 COSMIC
COSN22813706 967 COSMIC
COSN21388044 1118 COSMIC
COSN31606555 1410 COSMIC
COSN30076089 1428 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs202128051 5 dbSNP
rs201010904 14 dbSNP
rs984446861 15 dbSNP
rs749342762 26 dbSNP
rs777742589 32 dbSNP
rs950435041 37 dbSNP
rs1265707601 44 dbSNP
rs769988455 49 dbSNP
rs995458029 56 dbSNP
rs748328560 58 dbSNP
rs138345513 63 dbSNP
rs997302546 66 dbSNP
rs755330097 68 dbSNP
rs374512193 69 dbSNP
rs1254943067 70 dbSNP
rs758926260 74 dbSNP
rs749882767 79 dbSNP
rs1276100551 85 dbSNP
rs1458343028 87 dbSNP
rs764667950 99 dbSNP
rs1338599769 107 dbSNP
rs756850917 108 dbSNP
rs150542583 131 dbSNP
rs140668058 137 dbSNP
rs138918468 138 dbSNP
rs150282653 139 dbSNP
rs1131691345 147 dbSNP
rs767519301 148 dbSNP
rs1306207782 152 dbSNP
rs759392096 163 dbSNP
rs773282992 165 dbSNP
rs1378618594 166 dbSNP
rs914557142 167 dbSNP
rs934640261 174 dbSNP
rs76614886 175 dbSNP
rs769746038 179 dbSNP
rs748325390 182 dbSNP
rs1415261171 184 dbSNP
rs776801688 185 dbSNP
rs370082539 189 dbSNP
rs1253358292 190 dbSNP
rs1201745906 196 dbSNP
rs771720832 200 dbSNP
rs1290493834 213 dbSNP
rs758882685 215 dbSNP
rs377725442 216 dbSNP
rs570575495 218 dbSNP
rs756694303 219 dbSNP
rs753450906 222 dbSNP
rs1183345847 228 dbSNP
rs140694378 232 dbSNP
rs755865233 237 dbSNP
rs202165165 243 dbSNP
rs1326072904 248 dbSNP
rs983443993 249 dbSNP
rs759430545 256 dbSNP
rs950357733 266 dbSNP
rs1394228956 273 dbSNP
rs774148629 287 dbSNP
rs766379247 289 dbSNP
rs761774859 291 dbSNP
rs1175035321 301 dbSNP
rs1166767723 305 dbSNP
rs1469165983 308 dbSNP
rs776713979 315 dbSNP
rs768826037 316 dbSNP
rs1467046444 320 dbSNP
rs747246177 322 dbSNP
rs1025927417 323 dbSNP
rs1209115377 324 dbSNP
rs993148827 328 dbSNP
rs775747589 329 dbSNP
rs1379191271 331 dbSNP
rs1230555188 334 dbSNP
rs536618371 341 dbSNP
rs1026027266 348 dbSNP
rs185264166 349 dbSNP
rs548595515 351 dbSNP
rs1334738430 360 dbSNP
rs1219691312 368 dbSNP
rs965816298 371 dbSNP
rs1260388613 376 dbSNP
rs1017380084 384 dbSNP
rs1204021597 399 dbSNP
rs886062948 404 dbSNP
rs528807483 410 dbSNP
rs1043608444 411 dbSNP
rs1415647495 411 dbSNP
rs369328057 411 dbSNP
rs181850921 419 dbSNP
rs893250848 419 dbSNP
rs934623746 419 dbSNP
rs999217631 420 dbSNP
rs928631504 421 dbSNP
rs1045979058 425 dbSNP
rs745429614 425 dbSNP
rs1355452437 430 dbSNP
rs916060804 430 dbSNP
rs1456684001 431 dbSNP
rs191034081 432 dbSNP
rs1188841315 440 dbSNP
rs563463528 441 dbSNP
rs1014220263 442 dbSNP
rs1419073942 444 dbSNP
rs1208897149 445 dbSNP
rs1250253992 446 dbSNP
rs918985241 456 dbSNP
rs1485308723 458 dbSNP
rs550632198 473 dbSNP
rs141658821 474 dbSNP
rs1243657646 487 dbSNP
rs1474282696 494 dbSNP
rs778539030 501 dbSNP
rs1291269583 510 dbSNP
rs1208330761 511 dbSNP
rs1415813750 517 dbSNP
rs540966698 519 dbSNP
rs886062947 529 dbSNP
rs1353968631 532 dbSNP
rs1171200571 536 dbSNP
rs1374261649 547 dbSNP
rs1420861050 551 dbSNP
rs941502789 555 dbSNP
rs561379422 556 dbSNP
rs1275799091 565 dbSNP
rs886062946 565 dbSNP
rs1022536182 568 dbSNP
rs73634656 581 dbSNP
rs1354445996 589 dbSNP
rs930236959 591 dbSNP
rs1350612950 596 dbSNP
rs1302119719 597 dbSNP
rs1217292628 603 dbSNP
rs1286311218 611 dbSNP
rs1445192894 635 dbSNP
rs1192282300 637 dbSNP
rs1246999291 639 dbSNP
rs918914394 644 dbSNP
rs1455313997 650 dbSNP
rs1191306973 654 dbSNP
rs975718860 654 dbSNP
rs1393986466 658 dbSNP
rs757140263 663 dbSNP
rs573181569 665 dbSNP
rs910263992 671 dbSNP
rs907161602 672 dbSNP
rs1324624296 681 dbSNP
rs1351928072 689 dbSNP
rs1410339964 697 dbSNP
rs1439015047 715 dbSNP
rs73675437 718 dbSNP
rs1472942886 722 dbSNP
rs1242474633 728 dbSNP
rs948977291 731 dbSNP
rs957223816 737 dbSNP
rs73675436 739 dbSNP
rs554681900 740 dbSNP
rs1453472703 742 dbSNP
rs886062945 743 dbSNP
rs1439908622 746 dbSNP
rs1183442060 747 dbSNP
rs186886753 750 dbSNP
rs1470088273 754 dbSNP
rs1049797575 758 dbSNP
rs1210159856 763 dbSNP
rs1460247190 764 dbSNP
rs1325629113 768 dbSNP
rs1464297072 769 dbSNP
rs1266131488 774 dbSNP
rs998770170 786 dbSNP
rs1335191582 792 dbSNP
rs868546274 793 dbSNP
rs919433806 796 dbSNP
rs1284747475 801 dbSNP
rs1336826924 803 dbSNP
rs971749939 808 dbSNP
rs944500618 835 dbSNP
rs1457938248 836 dbSNP
rs1273802655 837 dbSNP
rs1230446660 838 dbSNP
rs1436685648 839 dbSNP
rs577136573 845 dbSNP
rs911553723 855 dbSNP
rs1323834178 856 dbSNP
rs1474508169 857 dbSNP
rs985843988 863 dbSNP
rs373353767 867 dbSNP
rs556767684 867 dbSNP
rs1424709325 868 dbSNP
rs544073908 871 dbSNP
rs1396001366 882 dbSNP
rs953401762 886 dbSNP
rs575175835 893 dbSNP
rs1336231421 894 dbSNP
rs558458038 899 dbSNP
rs1014167817 905 dbSNP
rs1323116435 908 dbSNP
rs901019051 912 dbSNP
rs989815627 916 dbSNP
rs894487223 921 dbSNP
rs1030839624 922 dbSNP
rs956490541 922 dbSNP
rs571654066 923 dbSNP
rs1055874390 924 dbSNP
rs1338323652 928 dbSNP
rs1006091074 944 dbSNP
rs1200598021 946 dbSNP
rs1378382021 959 dbSNP
rs1192798186 962 dbSNP
rs1464254543 965 dbSNP
rs11557527 970 dbSNP
rs1187794524 971 dbSNP
rs1264383262 974 dbSNP
rs1210509607 986 dbSNP
rs1372781609 992 dbSNP
rs1465241244 996 dbSNP
rs1024713146 1000 dbSNP
rs1175606447 1000 dbSNP
rs1432811490 1001 dbSNP
rs1312158316 1009 dbSNP
rs1277847981 1011 dbSNP
rs1198182914 1014 dbSNP
rs181767250 1027 dbSNP
rs1293166190 1028 dbSNP
rs114447974 1029 dbSNP
rs1275046850 1032 dbSNP
rs1227280859 1033 dbSNP
rs894481268 1042 dbSNP
rs534947228 1045 dbSNP
rs1281868483 1046 dbSNP
rs1345063859 1048 dbSNP
rs1209487652 1062 dbSNP
rs138126515 1062 dbSNP
rs1300186447 1063 dbSNP
rs930899546 1065 dbSNP
rs1185212442 1073 dbSNP
rs755924475 1079 dbSNP
rs1433997235 1083 dbSNP
rs1195681599 1084 dbSNP
rs1041322883 1086 dbSNP
rs59531993 1087 dbSNP
rs1453914206 1101 dbSNP
rs1159309700 1102 dbSNP
rs1345779271 1107 dbSNP
rs1332802538 1110 dbSNP
rs1286910108 1113 dbSNP
rs532547179 1115 dbSNP
rs1480200060 1119 dbSNP
rs1416213304 1120 dbSNP
rs1403064380 1141 dbSNP
rs189683667 1151 dbSNP
rs1368304237 1157 dbSNP
rs911671151 1157 dbSNP
rs986304714 1159 dbSNP
rs1319255919 1172 dbSNP
rs910245417 1173 dbSNP
rs985879187 1177 dbSNP
rs1488989176 1183 dbSNP
rs1392262737 1185 dbSNP
rs1251426946 1192 dbSNP
rs1468196682 1204 dbSNP
rs186352130 1214 dbSNP
rs1410175009 1226 dbSNP
rs931636160 1229 dbSNP
rs766649875 1231 dbSNP
rs1156786774 1233 dbSNP
rs577174492 1235 dbSNP
rs914897145 1239 dbSNP
rs1327653989 1243 dbSNP
rs1185385873 1252 dbSNP
rs1391917689 1252 dbSNP
rs925738010 1254 dbSNP
rs989371367 1256 dbSNP
rs1443624094 1261 dbSNP
rs34316364 1279 dbSNP
rs4737075 1279 dbSNP
rs1222595985 1282 dbSNP
rs558640226 1283 dbSNP
rs547826107 1294 dbSNP
rs1235595832 1306 dbSNP
rs765396461 1309 dbSNP
rs1024141590 1311 dbSNP
rs528366078 1314 dbSNP
rs1024365252 1315 dbSNP
rs886062944 1316 dbSNP
rs1234701613 1318 dbSNP
rs1229540781 1324 dbSNP
rs1479720065 1328 dbSNP
rs958733577 1330 dbSNP
rs1176666065 1340 dbSNP
rs766047041 1350 dbSNP
rs181590307 1360 dbSNP
rs752380722 1363 dbSNP
rs1475491308 1368 dbSNP
rs1166831464 1369 dbSNP
rs1378952055 1372 dbSNP
rs1028109843 1374 dbSNP
rs1170660174 1376 dbSNP
rs535976324 1382 dbSNP
rs995044388 1397 dbSNP
rs1034789544 1417 dbSNP
rs1005624341 1418 dbSNP
rs888502636 1422 dbSNP
rs762200222 1423 dbSNP
rs994298560 1430 dbSNP
rs1291841569 1436 dbSNP
rs901351289 1440 dbSNP
rs142802423 1441 dbSNP
rs1275437055 1445 dbSNP
rs1305969632 1467 dbSNP
rs890630700 1468 dbSNP
rs1169500691 1475 dbSNP
rs1485966126 1479 dbSNP
rs1189919044 1480 dbSNP
rs1050147084 1482 dbSNP
rs1474781993 1495 dbSNP
rs577105893 1505 dbSNP
rs931724745 1507 dbSNP
rs528126268 1519 dbSNP
rs942954933 1520 dbSNP
rs1437154222 1521 dbSNP
rs1311632626 1526 dbSNP
rs543106396 1534 dbSNP
rs574487492 1536 dbSNP
rs1431999750 1542 dbSNP
rs1272282265 1565 dbSNP
rs1360138072 1570 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084040. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep1 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' caGGGUUCUCGGACUGAACACu 5'
            ||||:    || ||||| | 
Target 5' auCCCAG----CU-ACUUGGGa 3'
4 - 20
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084040
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep1
Location of target site ENST00000345117.2 | 3UTR | GUGAUCCCAGCUACUUGGGAGGCUGAGGCAGGAGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE32688 Pancreatic cancer -0.544 6.4e-4 -0.485 2.5e-3 32 Click to see details
GSE38226 Liver fibrosis 0.502 1.0e-2 0.490 1.2e-2 21 Click to see details
GSE21687 Ependynoma primary tumors 0.277 1.3e-2 0.300 8.0e-3 64 Click to see details
GSE28544 Breast cancer -0.44 1.6e-2 -0.408 2.4e-2 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.345 4.6e-2 0.241 1.2e-1 25 Click to see details
GSE42095 Differentiated embryonic stem cells -0.334 6.0e-2 -0.612 9.6e-4 23 Click to see details
GSE21032 Prostate cancer 0.164 6.9e-2 0.067 2.7e-1 83 Click to see details
GSE17498 Multiple myeloma 0.23 7.7e-2 0.245 6.4e-2 40 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.872 1.6e-1 -0.500 3.3e-1 3 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.13 2.9e-1 0.493 1.4e-2 20 Click to see details
GSE19350 CNS germ cell tumors 0.154 3.2e-1 0.089 3.9e-1 12 Click to see details
GSE26953 Aortic valvular endothelial cells -0.094 3.3e-1 -0.184 1.9e-1 24 Click to see details
GSE19783 ER+ ER+ breast cancer -0.098 3.4e-1 -0.054 4.1e-1 20 Click to see details
GSE19536 Breast cancer -0.025 4.0e-1 -0.013 4.5e-1 100 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.037 4.3e-1 0.260 1.0e-1 25 Click to see details
GSE28260 Renal cortex and medulla 0.047 4.4e-1 0.165 3.0e-1 13 Click to see details
GSE19783 ER- ER- breast cancer 0.005 4.8e-1 0.024 4.2e-1 79 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA -0.273 0.01 -0.241 0.01 84 Click to see details
THCA 0.297 0.01 0.292 0.01 59 Click to see details
KIRP 0.352 0.02 0.288 0.05 32 Click to see details
COAD 0.694 0.03 0.714 0.02 8 Click to see details
PAAD -0.884 0.06 -1.000 0.5 4 Click to see details
STAD 0.279 0.06 0.262 0.07 32 Click to see details
PRAD -0.19 0.09 -0.230 0.05 50 Click to see details
CHOL 0.449 0.11 0.333 0.19 9 Click to see details
PCPG -0.901 0.14 -1.000 0.5 3 Click to see details
LUAD -0.23 0.24 -0.210 0.26 12 Click to see details
ESCA 0.191 0.29 0.273 0.21 11 Click to see details
UCEC 0.134 0.29 0.300 0.11 19 Click to see details
LIHC 0.079 0.29 -0.003 0.49 49 Click to see details
BLCA 0.136 0.3 -0.131 0.3 18 Click to see details
KICH -0.092 0.33 -0.160 0.22 25 Click to see details
CESC 0.372 0.38 0.500 0.33 3 Click to see details
KIRC 0.037 0.38 0.108 0.19 68 Click to see details
HNSC -0.042 0.4 0.028 0.43 42 Click to see details
LUSC 0.026 0.44 0.103 0.27 38 Click to see details
LUSC 0.026 0.44 0.103 0.27 38 Click to see details
LUSC 0.026 0.44 0.103 0.27 38 Click to see details
91 hsa-miR-125b-2-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038624 HN1L Jupiter microtubule associated homolog 2 1 1
MIRT038625 KDELC2 KDEL motif containing 2 1 1
MIRT038626 ABHD15 abhydrolase domain containing 15 1 1
MIRT038627 PPP1R12C protein phosphatase 1 regulatory subunit 12C 1 1
MIRT038628 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 1 1
MIRT038629 ASH2L ASH2 like histone lysine methyltransferase complex subunit 1 1
MIRT038630 USP22 ubiquitin specific peptidase 22 1 1
MIRT038631 CSTB cystatin B 1 1
MIRT038632 SYT2 synaptotagmin 2 1 1
MIRT038633 NDUFS7 NADH:ubiquinone oxidoreductase core subunit S7 1 1
MIRT038634 MTA2 metastasis associated 1 family member 2 1 1
MIRT053086 IGF1R insulin like growth factor 1 receptor 3 1
MIRT055788 PLEKHA1 pleckstrin homology domain containing A1 2 12
MIRT061248 AMOTL1 angiomotin like 1 2 10
MIRT061649 BTG2 BTG anti-proliferation factor 2 2 6
MIRT079046 TNRC6C trinucleotide repeat containing 6C 2 4
MIRT084583 BCL2L11 BCL2 like 11 2 8
MIRT093523 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 2
MIRT097383 LHFPL2 LHFPL tetraspan subfamily member 2 2 4
MIRT098030 SOBP sine oculis binding protein homolog 2 2
MIRT186262 TCEB3 elongin A 2 2
MIRT187284 DAZAP2 DAZ associated protein 2 2 10
MIRT361113 LRRC1 leucine rich repeat containing 1 2 2
MIRT443585 FAM84B family with sequence similarity 84 member B 2 2
MIRT452249 TRAM1 translocation associated membrane protein 1 2 2
MIRT476289 GMFB glia maturation factor beta 2 8
MIRT483871 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT484250 ANK1 ankyrin 1 2 2
MIRT499251 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502270 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504652 RPL9 ribosomal protein L9 2 6
MIRT505210 UBN2 ubinuclein 2 2 6
MIRT512690 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT517341 ZNF529 zinc finger protein 529 2 4
MIRT518946 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520866 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT521236 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT528324 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT533297 USP46 ubiquitin specific peptidase 46 2 2
MIRT541024 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT544034 ERRFI1 ERBB receptor feedback inhibitor 1 2 2
MIRT547037 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556102 MOAP1 modulator of apoptosis 1 2 2
MIRT558320 DR1 down-regulator of transcription 1 2 2
MIRT558520 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT566230 PTMA prothymosin, alpha 2 4
MIRT568437 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570584 OTUD7B OTU deubiquitinase 7B 2 2
MIRT571384 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572798 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573864 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT609930 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610437 CSMD2 CUB and Sushi multiple domains 2 2 2
MIRT614407 MURC caveolae associated protein 4 2 2
MIRT618625 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620605 SAP30 Sin3A associated protein 30 2 2
MIRT635313 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635918 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT638507 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT640597 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT644066 IQCE IQ motif containing E 2 2
MIRT648287 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT653089 SSR3 signal sequence receptor subunit 3 2 2
MIRT654651 PTAFR platelet activating factor receptor 2 2
MIRT658084 FOXR2 forkhead box R2 2 2
MIRT665306 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665974 SYTL4 synaptotagmin like 4 2 2
MIRT674905 RASSF9 Ras association domain family member 9 2 2
MIRT680085 THAP1 THAP domain containing 1 2 2
MIRT681487 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691243 DFNB59 pejvakin 2 2
MIRT692361 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693034 MB21D1 Mab-21 domain containing 1 2 2
MIRT694478 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696069 ZNF264 zinc finger protein 264 2 2
MIRT696579 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696759 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697306 ZNF652 zinc finger protein 652 2 2
MIRT698736 STX12 syntaxin 12 2 2
MIRT701055 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701197 OTUD3 OTU deubiquitinase 3 2 2
MIRT701334 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT703617 FBXO45 F-box protein 45 2 2
MIRT708893 ZNF780A zinc finger protein 780A 2 2
MIRT711621 DGKH diacylglycerol kinase eta 2 2
MIRT713744 TMEM81 transmembrane protein 81 2 2
MIRT715060 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT719711 CD101 CD101 molecule 2 2
MIRT720293 DLGAP3 DLG associated protein 3 2 2
MIRT722605 CCDC152 coiled-coil domain containing 152 2 2
MIRT724565 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-125b-2 Ascorbate approved 54670067 Microarray Metastatic melanoma cell lines 25202679 2014 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-125b-2 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-125b-2 Methotrexate 126941 NSC740 approved resistant High Colorectal Adenocarcinoma cell line (HT-29)
hsa-mir-125b-2 Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia tissue
hsa-mir-125b-2 Doxorubicin 31703 NSC123127 approved sensitive Low Hepatocellular Carcinoma cell line (Huh-7, HLE, HuH1)
hsa-mir-125b-2 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375)
hsa-mir-125b-2 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-125b-2 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-125b-2 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-125b-2 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-125b-2 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-mir-125b-2 Tamoxifen 2733525 NSC180973 approved resistant tissue (ER-positive breast cancer)
hsa-mir-125b-2 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-125b-2 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-125b-2-3p Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901)
hsa-miR-125b-2-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-125b-2-3p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-125b-2-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer tissue
hsa-miR-125b-2-3p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer tissue
hsa-miR-125b-2-3p Cyclophosphamide + Doxorubicin + Vincristine + Prednisone + Rituximab resistant High Diffuse Large B-Cell Lymphoma cell line (SU-DHL-2)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901, BGC-823)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Lung Adenocarcinoma cell line (A549)
hsa-miR-125b-2-3p Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (HCT8, HCT-116)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-miR-125b-2-3p Antiepileptic Drug sensitive High Pediatric Epilepsy tissue
hsa-miR-125b-2-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-125b-2-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-125b-2-3p 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-miR-125b-2-3p Ethanol+Tamoxifen resistant cell line (LY2)
hsa-miR-125b-2-3p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-125b-2-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-125b-2-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-125b-2-3p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR70)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-125b-2-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-125b-2-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-125b-2-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (SGC-7901)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)

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