miRTarBase - #MIRT682783


—
pre-miRNA Information
pre-miRNA hsa-mir-1268b   
Genomic Coordinates chr17: 80098828 - 80098877
Description Homo sapiens miR-1268b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1268b
Sequence 4| CGGGCGUGGUGGUGGGGGUG |23
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs565586973 1 dbSNP
rs1007008765 2 dbSNP
rs1405843504 4 dbSNP
rs535896040 5 dbSNP
rs532706583 6 dbSNP
rs1290047771 7 dbSNP
rs1228621577 10 dbSNP
rs1377910066 10 dbSNP
rs1282084939 12 dbSNP
rs1449528405 13 dbSNP
rs148335705 13 dbSNP
rs893367645 16 dbSNP
rs1222208792 18 dbSNP
rs1456165025 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol BLOC1S3   
Synonyms BLOS3, HPS8, RP
Description biogenesis of lysosomal organelles complex 1 subunit 3
Transcript NM_212550   
Expression
Putative miRNA Targets on BLOC1S3
3'UTR of BLOC1S3
(miRNA target sites are highlighted)		 
>BLOC1S3|NM_212550|3'UTR
   1 CCATGATTCTACTTCCCAACCTGACTGCAATTTGGGGGTAGGCCTTGCTGCCTCTGGGACCTGACTCTGTCTCCTGTGTC
  81 TCTTATCACCCCCCACCCCCGCTCCCATCTTGGTGTCACCCATGGGGGCTAATCCGGTCCCCTTGGATAATGCTTTATAT
 161 TGGATATAGTTCAACCCCTACTGCGGAGACCAGGGCCCCACTATCCTTAGATCTGGTTCCTCTCCCGATCCTGACCCTGC
 241 CGCCTGGTTCTGAGCCTTCCCCTGGGGCTTGGCTCCAGCCTTTGTTACATAGTTGCTCCTTAATCTGTTTCCACCCTGGG
 321 GGCTCACCAATTTTTTTTTTTTTTTTTTTTTTTTGGAGACAGGGTGTTTATCTGTCACCCAGGCTAGAGTGCAGTGGCGG
 401 GATTACTGCTCACTGCAACCTCGACCTCCTGGGCTCAAGTGATCCTCCCAGCTCAGCCTTCAAGAGTAGCTGGGACTGCA
 481 GACCTGCACCACCACGTCCAGCTGCCCGGTTAATTTTTTTCTGTCGGTTTGAAGAGGGGAGAAGGTCTCACTATGTTGCC
 561 CAGGCTTGTCTCAAACTCCCGGGCTCAAGCAATCCTCCCACTGTGGCGTCCCAAAGTGCTGGGGTTACAGGTGTGAGCCA
 641 CCACACACTGGGCTCTGCTCTGCCTTTCTGAGTTTGGTTTCTGCTTATGGTGGGGAGCTTGTTCCCGTTCTTCCCACAAG
 721 AACCCAGGATGTGGCACAGCTTCCCTGCCGTCTTCCTTCACTCAGTTGGCTACGCCTCCCATCCTAGCTCCACTTCCAGA
 801 ACTGCCTTCACCCTAGGCTGGGTCCTTGTTTTGTTTTTAGAGACAGGGTCTCACTGTGTCTCCCAGGCTGGAGTACAGTG
 881 GCGTGATCTCGGCTCACTGCCACCTCCACCTCCCGAGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTAGGATT
 961 ACAGGCATGCACCACCACGCCTGGCTACTTTTTATATTTTTAGTAGAGATGAGGTTTCACCTTGTTGGCCAGGCTGGTCT
1041 CGAACTCCTGGCCTCAGGTGATCCACCCGCCTCACCTCCTAAAATGCTGGGATTACAGGCGTGGGCCACTGCGCCTAGCC
1121 AGCTGGGTCCTTGTTCTGCTGCCCAAGCTTGGCCCTGGTTCCGTGTGCTGGTTCTACTTTTTGTTCTCCCATCTGCCTCC
1201 TGCCTCCTCCCCTTTGAGCTTAGCCCCGCCCTCTCAGCCTGATTTCTGTTTCCCAAGTCCAGCAGTGTCGTGGGATAGGT
1281 TTTGCTTTCTTTTACTGTCTCCATCCTACTTACACCTCCCTGATCCTGGGGTCTGGGGACTCCCCATGGTTTCCTTCCTT
1361 CTGCAGGCCCAAAATGATGGCCCCTCTTAACCCAAGGCAGGGGATCTTCCTCCCAACTCCCTGGACCAAGGTGGCATTTC
1441 CTGCACACCCCTCCAGGCCAAGATGATGCTCGCTCTCAACTCTGTAGGCCAAGGTGGCGTCTCCTCTTGACTCTCCAGAC
1521 CTAAAGTGACACCCTTCAGGCACTTCGGGCCCAATTCAGCCCAGTCCTGGTGCTTTCAGCGCCAGATGACAGCACTTTGC
1601 AGATAAGAACGATATGATGTGTGGATTTCACTACATTTGGCTCCTGGATGCTATAAAAGGACTTGGATTTCTGACTTGGC
1681 TCAGGGACTGGGGTTAGCAGTCTCTTTCTGCTCCTTTTCACCTGTGTTTTCTTCCGATCCCAGCTCTGGTCCCTCAGCCG
1761 CATTCATATTTACTCTCCTCTCCCAGCCTGATATCCCTGTCCCTCATCTCAACCCGAAGCCAAGATCTGAGCCCCCAAGA
1841 TGGAGAATGGGGAGGAGCTTTTTATGGCGGACTGATTAAAACTCTTAAGCATTTACAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' guGGGGGUGGUGGUGCGGGc 5'
            ||: ||||||||||:|| 
Target 5' gaCCTGCACCACCACGTCCa 3'
 481 - 500 162.00 -32.80
2 
miRNA  3' guggggGUGGUGGUGCGGGc 5'
                ||||||||||||: 
Target 5' ggcatgCACCACCACGCCTg 3'
 964 - 983 154.00 -30.10
3 
miRNA  3' guGGGGGUGGUGGUGCGGGc 5'
            |||||||| ||:| ||| 
Target 5' acCCCCCACCCCCGCTCCCa 3'
 88 - 107 134.00 -30.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
195447 1 ClinVar
329479 156 ClinVar
COSN23015398 11 COSMIC
COSN28884052 13 COSMIC
COSN27653544 37 COSMIC
COSN31535299 102 COSMIC
COSN15623317 110 COSMIC
COSN31583850 113 COSMIC
COSN26958099 169 COSMIC
COSN5858147 185 COSMIC
COSN15623318 257 COSMIC
COSN26644396 317 COSMIC
COSN26505171 331 COSMIC
COSN19580292 414 COSMIC
COSN30542512 568 COSMIC
COSN31594737 592 COSMIC
COSN8605958 600 COSMIC
COSN31543256 608 COSMIC
COSN30511947 657 COSMIC
COSN30511945 658 COSMIC
COSN31489290 671 COSMIC
COSN26640160 774 COSMIC
COSN15623319 780 COSMIC
COSN31570520 826 COSMIC
COSN30122016 916 COSMIC
COSN31539546 1070 COSMIC
COSN26635184 1168 COSMIC
COSN31544225 1187 COSMIC
COSN31588084 1192 COSMIC
COSN31543885 1229 COSMIC
COSN30120749 1286 COSMIC
COSN19493004 1313 COSMIC
COSN15623320 1326 COSMIC
COSN31590289 1381 COSMIC
COSN31550151 1396 COSMIC
COSN16129487 1490 COSMIC
COSN15623321 1494 COSMIC
COSN25871376 1499 COSMIC
COSN21154317 1547 COSMIC
COSN32057296 1581 COSMIC
COSN31575655 1674 COSMIC
COSN15779592 1691 COSMIC
COSN28682887 1814 COSMIC
COSN20093621 1830 COSMIC
COSN31530515 1839 COSMIC
COSN30528601 1876 COSMIC
COSN20618800 1891 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs142688123 1 dbSNP
rs761566196 3 dbSNP
rs1444892085 4 dbSNP
rs376405849 7 dbSNP
rs764955305 9 dbSNP
rs35338638 10 dbSNP
rs750170358 12 dbSNP
rs1384993823 16 dbSNP
rs368261458 18 dbSNP
rs372509527 21 dbSNP
rs377178343 22 dbSNP
rs781362128 24 dbSNP
rs187399565 29 dbSNP
rs770094438 30 dbSNP
rs1363948014 31 dbSNP
rs777965410 32 dbSNP
rs749527953 35 dbSNP
rs770932040 36 dbSNP
rs374759575 40 dbSNP
rs772376105 40 dbSNP
rs768620173 46 dbSNP
rs776477608 48 dbSNP
rs532054271 50 dbSNP
rs765184324 52 dbSNP
rs750035810 53 dbSNP
rs1448705096 54 dbSNP
rs1288330616 58 dbSNP
rs902867467 68 dbSNP
rs886054491 70 dbSNP
rs1311616229 75 dbSNP
rs1334341583 83 dbSNP
rs1238085424 89 dbSNP
rs1032770235 90 dbSNP
rs1304448782 91 dbSNP
rs928621630 95 dbSNP
rs1351464042 96 dbSNP
rs552139493 97 dbSNP
rs1053258669 101 dbSNP
rs1022781192 106 dbSNP
rs971751005 107 dbSNP
rs891971173 110 dbSNP
rs1379239990 114 dbSNP
rs947548441 116 dbSNP
rs981398043 127 dbSNP
rs1245381309 129 dbSNP
rs1043521419 137 dbSNP
rs903581380 141 dbSNP
rs1305165933 147 dbSNP
rs1198747097 148 dbSNP
rs1448031490 156 dbSNP
rs570559399 156 dbSNP
rs886054492 158 dbSNP
rs974035116 159 dbSNP
rs1007254633 169 dbSNP
rs1221222672 175 dbSNP
rs1017701626 176 dbSNP
rs1369428507 177 dbSNP
rs1272910928 184 dbSNP
rs1435531346 193 dbSNP
rs932719183 196 dbSNP
rs901486118 197 dbSNP
rs1467575606 201 dbSNP
rs997437119 208 dbSNP
rs1026203488 213 dbSNP
rs1422646601 214 dbSNP
rs1172319654 215 dbSNP
rs1478355408 223 dbSNP
rs1265904148 226 dbSNP
rs1457618347 226 dbSNP
rs908384591 227 dbSNP
rs1488002584 229 dbSNP
rs924156866 230 dbSNP
rs1423833572 231 dbSNP
rs1310616558 234 dbSNP
rs950565662 236 dbSNP
rs76467674 241 dbSNP
rs1016375313 242 dbSNP
rs970536894 245 dbSNP
rs148427902 247 dbSNP
rs1280007891 249 dbSNP
rs928647238 251 dbSNP
rs1398111549 255 dbSNP
rs938658189 261 dbSNP
rs1302866297 262 dbSNP
rs1449622721 268 dbSNP
rs1399221031 274 dbSNP
rs1174931466 276 dbSNP
rs1466457703 277 dbSNP
rs1426318538 281 dbSNP
rs6509200 286 dbSNP
rs913469463 287 dbSNP
rs947596880 291 dbSNP
rs1396672702 300 dbSNP
rs368390636 303 dbSNP
rs1183637718 306 dbSNP
rs189672488 308 dbSNP
rs371023414 314 dbSNP
rs1003084258 315 dbSNP
rs889927229 316 dbSNP
rs1259803827 319 dbSNP
rs568334676 321 dbSNP
rs1045877658 327 dbSNP
rs1259304857 329 dbSNP
rs1181470607 331 dbSNP
rs1223763058 331 dbSNP
rs1236613283 331 dbSNP
rs1240271818 331 dbSNP
rs1265946085 331 dbSNP
rs1306639984 331 dbSNP
rs1311452688 331 dbSNP
rs1319371395 331 dbSNP
rs1378607734 331 dbSNP
rs1446436917 331 dbSNP
rs1480194631 331 dbSNP
rs34965337 331 dbSNP
rs60498449 331 dbSNP
rs747825460 332 dbSNP
rs1295766348 333 dbSNP
rs1202883154 334 dbSNP
rs1456881519 336 dbSNP
rs1238832685 337 dbSNP
rs1038756617 355 dbSNP
rs1159285961 355 dbSNP
rs1421594896 355 dbSNP
rs1378636629 356 dbSNP
rs1178321433 360 dbSNP
rs1267843530 361 dbSNP
rs1418279847 361 dbSNP
rs1483413039 364 dbSNP
rs1192828255 365 dbSNP
rs537234718 367 dbSNP
rs1290989895 369 dbSNP
rs961274233 371 dbSNP
rs1478532390 373 dbSNP
rs1283428897 377 dbSNP
rs995488894 386 dbSNP
rs901521454 388 dbSNP
rs117001334 390 dbSNP
rs1407985937 391 dbSNP
rs1367434592 402 dbSNP
rs927543670 403 dbSNP
rs1026929560 406 dbSNP
rs1401908764 410 dbSNP
rs1047698629 411 dbSNP
rs1158240934 412 dbSNP
rs1466789499 414 dbSNP
rs1379612337 418 dbSNP
rs1466788232 419 dbSNP
rs985580629 426 dbSNP
rs142584236 427 dbSNP
rs1353601037 429 dbSNP
rs1401927889 432 dbSNP
rs1279327453 433 dbSNP
rs1006090146 437 dbSNP
rs550362452 444 dbSNP
rs1204055990 447 dbSNP
rs1016517016 448 dbSNP
rs182068302 465 dbSNP
rs115683085 466 dbSNP
rs1231446799 466 dbSNP
rs924230500 473 dbSNP
rs185088220 488 dbSNP
rs1281221121 490 dbSNP
rs1221045820 491 dbSNP
rs1312392407 496 dbSNP
rs1297606184 497 dbSNP
rs1208931684 498 dbSNP
rs1277752513 499 dbSNP
rs1002040561 502 dbSNP
rs775607885 506 dbSNP
rs1488949490 508 dbSNP
rs368024066 514 dbSNP
rs948347510 514 dbSNP
rs1044157395 520 dbSNP
rs906938163 522 dbSNP
rs1171289119 526 dbSNP
rs1478731192 532 dbSNP
rs1421398789 536 dbSNP
rs1262379029 540 dbSNP
rs960055233 545 dbSNP
rs1191800347 553 dbSNP
rs541332923 554 dbSNP
rs1474408046 563 dbSNP
rs1257810226 576 dbSNP
rs1198414292 578 dbSNP
rs1002746754 581 dbSNP
rs1259174286 581 dbSNP
rs561150528 584 dbSNP
rs1036806146 585 dbSNP
rs574712542 593 dbSNP
rs913520491 596 dbSNP
rs1026835663 598 dbSNP
rs1452269012 600 dbSNP
rs543635649 604 dbSNP
rs762649204 609 dbSNP
rs1173177265 612 dbSNP
rs563411988 613 dbSNP
rs189995520 619 dbSNP
rs978996897 620 dbSNP
rs1019731510 623 dbSNP
rs551937969 624 dbSNP
rs1184943925 625 dbSNP
rs1298953252 628 dbSNP
rs1200867642 630 dbSNP
rs942852799 632 dbSNP
rs183067434 638 dbSNP
rs1210998504 642 dbSNP
rs924094637 642 dbSNP
rs1429304723 648 dbSNP
rs922996709 653 dbSNP
rs958167071 654 dbSNP
rs1263701427 657 dbSNP
rs1390551030 660 dbSNP
rs933010449 661 dbSNP
rs1311770622 665 dbSNP
rs1448693262 672 dbSNP
rs58074751 673 dbSNP
rs1333807757 676 dbSNP
rs1328096807 683 dbSNP
rs1405941386 688 dbSNP
rs528043258 690 dbSNP
rs1160880046 691 dbSNP
rs916798023 696 dbSNP
rs1368661278 697 dbSNP
rs948446349 698 dbSNP
rs1180174804 703 dbSNP
rs1438184284 704 dbSNP
rs1232728340 706 dbSNP
rs1453768487 707 dbSNP
rs980170715 708 dbSNP
rs1047418163 717 dbSNP
rs1221784132 725 dbSNP
rs1354567080 734 dbSNP
rs1288390509 735 dbSNP
rs928426500 750 dbSNP
rs1348259627 756 dbSNP
rs1300786501 761 dbSNP
rs886069784 765 dbSNP
rs1474021065 773 dbSNP
rs1355488525 774 dbSNP
rs1186509062 779 dbSNP
rs938415860 781 dbSNP
rs1284747621 784 dbSNP
rs59591789 788 dbSNP
rs1398647478 792 dbSNP
rs1036711834 793 dbSNP
rs1173488406 811 dbSNP
rs1223620664 812 dbSNP
rs796862928 814 dbSNP
rs931110092 819 dbSNP
rs1199381894 825 dbSNP
rs1488656581 832 dbSNP
rs1265503645 835 dbSNP
rs937562978 845 dbSNP
rs1037596802 856 dbSNP
rs1446574607 859 dbSNP
rs1048308164 861 dbSNP
rs150959722 863 dbSNP
rs1346919404 864 dbSNP
rs1001358783 866 dbSNP
rs1393497939 868 dbSNP
rs1281265842 883 dbSNP
rs1222895758 884 dbSNP
rs1006932406 890 dbSNP
rs1299430746 892 dbSNP
rs1035777652 893 dbSNP
rs1020016613 903 dbSNP
rs1344191841 904 dbSNP
rs764004487 905 dbSNP
rs1416490602 906 dbSNP
rs1441822460 907 dbSNP
rs1427719620 908 dbSNP
rs901288065 910 dbSNP
rs371885127 913 dbSNP
rs1407291168 915 dbSNP
rs999626019 916 dbSNP
rs1485596799 925 dbSNP
rs188598670 926 dbSNP
rs1261082507 927 dbSNP
rs1010243849 937 dbSNP
rs1318463950 939 dbSNP
rs958197958 945 dbSNP
rs1020245476 946 dbSNP
rs111903160 947 dbSNP
rs1403458388 950 dbSNP
rs979436683 954 dbSNP
rs1440620315 958 dbSNP
rs550753235 966 dbSNP
rs1324343744 967 dbSNP
rs979819412 969 dbSNP
rs911463692 971 dbSNP
rs1169013814 980 dbSNP
rs570917374 984 dbSNP
rs964583045 994 dbSNP
rs1414704595 995 dbSNP
rs928302654 996 dbSNP
rs1442942752 999 dbSNP
rs976942512 1002 dbSNP
rs923047748 1004 dbSNP
rs1308118193 1010 dbSNP
rs1347838597 1019 dbSNP
rs1458088106 1038 dbSNP
rs1229551614 1039 dbSNP
rs1202437336 1042 dbSNP
rs1306403411 1046 dbSNP
rs370426154 1050 dbSNP
rs1229543446 1059 dbSNP
rs755013546 1063 dbSNP
rs1047492712 1065 dbSNP
rs1447950707 1069 dbSNP
rs553156600 1070 dbSNP
rs1296950239 1075 dbSNP
rs941694172 1076 dbSNP
rs1350985260 1079 dbSNP
rs1166916899 1082 dbSNP
rs1038047058 1085 dbSNP
rs116251719 1087 dbSNP
rs535827858 1092 dbSNP
rs1458066968 1093 dbSNP
rs1179454967 1099 dbSNP
rs1175282245 1101 dbSNP
rs937206994 1101 dbSNP
rs554947014 1102 dbSNP
rs889734463 1105 dbSNP
rs942601336 1107 dbSNP
rs1040940662 1109 dbSNP
rs895613848 1113 dbSNP
rs1240506389 1114 dbSNP
rs1356276314 1116 dbSNP
rs1305231482 1121 dbSNP
rs1391178857 1122 dbSNP
rs1010294703 1123 dbSNP
rs1368864788 1126 dbSNP
rs141286841 1133 dbSNP
rs781377437 1133 dbSNP
rs1403153114 1142 dbSNP
rs1020296333 1145 dbSNP
rs999490044 1152 dbSNP
rs1163427838 1153 dbSNP
rs1159462368 1158 dbSNP
rs574772380 1163 dbSNP
rs1031123394 1164 dbSNP
rs1156619555 1171 dbSNP
rs1418306279 1172 dbSNP
rs1425757802 1179 dbSNP
rs904550446 1192 dbSNP
rs1000181026 1194 dbSNP
rs1267623706 1196 dbSNP
rs1216719572 1197 dbSNP
rs143399677 1198 dbSNP
rs1258614245 1203 dbSNP
rs1238756900 1206 dbSNP
rs964317834 1207 dbSNP
rs1431296002 1209 dbSNP
rs976966379 1211 dbSNP
rs557121091 1213 dbSNP
rs760652394 1227 dbSNP
rs749917842 1228 dbSNP
rs1345451603 1247 dbSNP
rs1298818032 1252 dbSNP
rs764702536 1252 dbSNP
rs576936281 1254 dbSNP
rs1383006185 1255 dbSNP
rs1334046283 1264 dbSNP
rs972365156 1270 dbSNP
rs952446725 1271 dbSNP
rs545902071 1272 dbSNP
rs748256999 1275 dbSNP
rs375016316 1278 dbSNP
rs79968982 1287 dbSNP
rs911061158 1298 dbSNP
rs941732046 1298 dbSNP
rs11669523 1299 dbSNP
rs1193701613 1307 dbSNP
rs755664764 1309 dbSNP
rs528119623 1314 dbSNP
rs1393812037 1316 dbSNP
rs541422676 1317 dbSNP
rs1259197742 1320 dbSNP
rs1197837478 1324 dbSNP
rs1483777040 1327 dbSNP
rs1265327381 1330 dbSNP
rs973086277 1332 dbSNP
rs1041365424 1337 dbSNP
rs922534514 1341 dbSNP
rs1324801345 1342 dbSNP
rs935357148 1342 dbSNP
rs926918507 1343 dbSNP
rs1189677786 1344 dbSNP
rs1295122323 1345 dbSNP
rs562085964 1347 dbSNP
rs1052414452 1350 dbSNP
rs879713453 1362 dbSNP
rs1338376899 1366 dbSNP
rs1468065388 1370 dbSNP
rs765731212 1375 dbSNP
rs758853439 1377 dbSNP
rs1171351728 1379 dbSNP
rs1405197938 1379 dbSNP
rs893922630 1380 dbSNP
rs1474938360 1381 dbSNP
rs1423966320 1385 dbSNP
rs1244629138 1395 dbSNP
rs753263213 1397 dbSNP
rs1056954878 1398 dbSNP
rs1426426742 1400 dbSNP
rs895666292 1404 dbSNP
rs554604574 1407 dbSNP
rs113072092 1414 dbSNP
rs1041807518 1417 dbSNP
rs1167767129 1421 dbSNP
rs1198148567 1423 dbSNP
rs1393835828 1428 dbSNP
rs1337515946 1442 dbSNP
rs1045130441 1443 dbSNP
rs531120532 1446 dbSNP
rs10425237 1454 dbSNP
rs904602648 1455 dbSNP
rs1385205900 1457 dbSNP
rs1313213662 1467 dbSNP
rs1000637685 1470 dbSNP
rs73939649 1472 dbSNP
rs1381855757 1473 dbSNP
rs1329444511 1474 dbSNP
rs1334429179 1476 dbSNP
rs571038530 1476 dbSNP
rs1394259463 1477 dbSNP
rs1354228276 1478 dbSNP
rs1334489878 1484 dbSNP
rs1386686048 1485 dbSNP
rs1161324626 1486 dbSNP
rs1444391997 1488 dbSNP
rs1035715134 1491 dbSNP
rs778241189 1492 dbSNP
rs567632512 1495 dbSNP
rs758633856 1499 dbSNP
rs778205907 1500 dbSNP
rs1361741496 1507 dbSNP
rs1025252330 1512 dbSNP
rs747159416 1521 dbSNP
rs1354712545 1522 dbSNP
rs1029909320 1527 dbSNP
rs952354586 1528 dbSNP
rs1341125171 1531 dbSNP
rs984298489 1534 dbSNP
rs1333859659 1542 dbSNP
rs910937341 1547 dbSNP
rs1346886325 1548 dbSNP
rs951551100 1556 dbSNP
rs964231841 1567 dbSNP
rs982947597 1571 dbSNP
rs757522265 1578 dbSNP
rs533346539 1582 dbSNP
rs1423544434 1587 dbSNP
rs868389116 1590 dbSNP
rs1485352603 1594 dbSNP
rs1380532867 1603 dbSNP
rs1160613431 1611 dbSNP
rs867174019 1612 dbSNP
rs935221747 1614 dbSNP
rs1490858114 1615 dbSNP
rs1208894954 1617 dbSNP
rs781613896 1620 dbSNP
rs1221853680 1621 dbSNP
rs1488718965 1636 dbSNP
rs114644261 1645 dbSNP
rs745911670 1647 dbSNP
rs10404558 1649 dbSNP
rs1278879381 1654 dbSNP
rs1478458528 1655 dbSNP
rs747345556 1656 dbSNP
rs1224106092 1659 dbSNP
rs191704392 1663 dbSNP
rs1045564383 1666 dbSNP
rs770064737 1683 dbSNP
rs1371651488 1684 dbSNP
rs1319932228 1686 dbSNP
rs905269479 1687 dbSNP
rs992732880 1691 dbSNP
rs775553024 1693 dbSNP
rs1056618303 1700 dbSNP
rs76151738 1701 dbSNP
rs1198724891 1702 dbSNP
rs1041522965 1712 dbSNP
rs1478217467 1716 dbSNP
rs1244031992 1719 dbSNP
rs1214001001 1735 dbSNP
rs1432317562 1737 dbSNP
rs74798348 1747 dbSNP
rs1361060614 1748 dbSNP
rs537363052 1753 dbSNP
rs952387101 1755 dbSNP
rs556943431 1760 dbSNP
rs577004295 1761 dbSNP
rs963808687 1769 dbSNP
rs1040166792 1774 dbSNP
rs1471175744 1779 dbSNP
rs899862584 1783 dbSNP
rs998170460 1785 dbSNP
rs1051387280 1787 dbSNP
rs887350899 1790 dbSNP
rs1332537420 1792 dbSNP
rs1184868986 1794 dbSNP
rs1233722549 1795 dbSNP
rs956502010 1796 dbSNP
rs1462523323 1800 dbSNP
rs751735876 1816 dbSNP
rs1208779488 1825 dbSNP
rs1017106237 1826 dbSNP
rs1261140017 1830 dbSNP
rs963180030 1833 dbSNP
rs1308020859 1839 dbSNP
rs988058690 1845 dbSNP
rs1212328500 1846 dbSNP
rs1338292601 1849 dbSNP
rs1315367601 1854 dbSNP
rs1454888652 1857 dbSNP
rs545659783 1859 dbSNP
rs1486249477 1869 dbSNP
rs184044224 1870 dbSNP
rs188059080 1874 dbSNP
rs1356791478 1882 dbSNP
rs1168367626 1890 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293/HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1067869. RNA binding protein: AGO2. Condition:Ago2 IP-seq (asynchronous cells) ...

- Kishore S; Gruber AR; Jedlinski DJ; Syed et al., 2013, Genome biology.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' guggggGUGGUGGUGCGGGc 5'
                ||||||||||||: 
Target 5' -gcaugCACCACCACGCCUg 3'
 		1 - 19
Article - Kishore S; Gruber AR; Jedlinski DJ; Syed et al.
- Genome biology, 2013
BACKGROUND: In recent years, a variety of small RNAs derived from other RNAs with well-known functions such as tRNAs and snoRNAs, have been identified. The functional relevance of these RNAs is largely unknown. To gain insight into the complexity of snoRNA processing and the functional relevance of snoRNA-derived small RNAs, we sequence long and short RNAs, small RNAs that co-precipitate with the Argonaute 2 protein and RNA fragments obtained in photoreactive nucleotide-enhanced crosslinking and immunoprecipitation (PAR-CLIP) of core snoRNA-associated proteins. RESULTS: Analysis of these data sets reveals that many loci in the human genome reproducibly give rise to C/D box-like snoRNAs, whose expression and evolutionary conservation are typically less pronounced relative to the snoRNAs that are currently cataloged. We further find that virtually all C/D box snoRNAs are specifically processed inside the regions of terminal complementarity, retaining in the mature form only 4-5 nucleotides upstream of the C box and 2-5 nucleotides downstream of the D box. Sequencing of the total and Argonaute 2-associated populations of small RNAs reveals that despite their cellular abundance, C/D box-derived small RNAs are not efficiently incorporated into the Ago2 protein. CONCLUSIONS: We conclude that the human genome encodes a large number of snoRNAs that are processed along the canonical pathway and expressed at relatively low levels. Generation of snoRNA-derived processing products with alternative, particularly miRNA-like, functions appears to be uncommon.
LinkOut: [PMID: 23706177]
CLIP-seq Support 1 for dataset GSM1067869
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293/HeLa / Ago2 IP-seq (asynchronous cells)
Location of target site ENST00000433642.2 | 3UTR | GCAUGCACCACCACGCCUGGCUAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23706177 / GSE43666
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
40 hsa-miR-1268b Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT473716 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT483653 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT484276 AIP aryl hydrocarbon receptor interacting protein 2 4
MIRT486673 WDR81 WD repeat domain 81 2 2
MIRT488670 WWP2 WW domain containing E3 ubiquitin protein ligase 2 2 4
MIRT493452 ITFG3 family with sequence similarity 234 member A 2 2
MIRT495901 ZNF641 zinc finger protein 641 2 2
MIRT500187 BARX1 BARX homeobox 1 2 4
MIRT512014 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT521132 SGPL1 sphingosine-1-phosphate lyase 1 2 4
MIRT530046 TRIM72 tripartite motif containing 72 2 2
MIRT531518 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT543735 DHCR7 7-dehydrocholesterol reductase 2 2
MIRT558053 EVI5L ecotropic viral integration site 5 like 2 2
MIRT569602 TRIM29 tripartite motif containing 29 2 2
MIRT570025 FAM228A family with sequence similarity 228 member A 2 2
MIRT573593 CERS1 ceramide synthase 1 2 2
MIRT623883 FRMPD4 FERM and PDZ domain containing 4 2 2
MIRT629999 PDE6B phosphodiesterase 6B 2 2
MIRT632715 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT633496 ERO1L endoplasmic reticulum oxidoreductase 1 alpha 1 1
MIRT637075 SELPLG selectin P ligand 2 2
MIRT638182 TLN1 talin 1 2 2
MIRT638766 EPB41 erythrocyte membrane protein band 4.1 2 2
MIRT668072 GMPS guanine monophosphate synthase 2 2
MIRT669873 RAET1E retinoic acid early transcript 1E 2 2
MIRT670663 KIAA1551 KIAA1551 2 2
MIRT671282 RPL37A ribosomal protein L37a 2 2
MIRT675054 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT682783 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 2
MIRT683343 SCARF1 scavenger receptor class F member 1 2 2
MIRT690282 ZNF154 zinc finger protein 154 2 2
MIRT695171 SLC25A33 solute carrier family 25 member 33 2 2
MIRT695221 SCAMP3 secretory carrier membrane protein 3 2 2
MIRT700484 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700600 PRKCA protein kinase C alpha 2 2
MIRT701409 NKRF NFKB repressing factor 2 2
MIRT703994 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT711231 RETSAT retinol saturase 2 2
MIRT719509 TMEM175 transmembrane protein 175 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1268b Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved resistant High Pancreatic Cancer cell line (BxPC-3)
hsa-miR-1268b Doxorubicin 31703 NSC123127 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-1268b Cytoxan + Pirarubicin + Fluorouracil sensitive High Breast Cancer tissue
hsa-miR-1268b Cytoxan + Doxorubicin + Fluorouracil sensitive High Breast Cancer tissue
hsa-miR-1268b Cytoxan + Epirubicin + Fluorouracil sensitive High Breast Cancer tissue
hsa-miR-1268b Doxorubicin + Taxol sensitive High Breast Cancer tissue
hsa-miR-1268b Erlotinib 176870 NSC718781 approved resistant High Head And Neck Squamous Cell Carcinoma cell line (HN6)
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-1268b Anthracycline 30323 NSC82151 approved sensitive High Breast Cancer tissue
hsa-miR-1268b Cyclophosphamide 2907 NSC26271 approved sensitive High Breast Cancer tissue
hsa-miR-1268b Fluorouracil 3385 NSC19893 approved sensitive High Breast Cancer tissue
hsa-miR-1268b Taxol 36314 NSC125973 approved sensitive High Breast Cancer tissue
hsa-miR-1268b Methotrexate 126941 NSC740 approved sensitive High Breast Cancer tissue
hsa-miR-1268b Doxorubicin 31703 NSC123127 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268b Paclitaxel 36314 NSC125973 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268b Etoposide 36462 NSC141540 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268b Vinorelbine 44424639 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268b Vincristine 5978 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-mir-1268b Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-1268b Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-1268b Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-1268b Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved resistant cell line (MDAH-2774)
hsa-miR-1268b Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)

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