pre-miRNA Information | |
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pre-miRNA | hsa-mir-873 |
Genomic Coordinates | chr9: 28888879 - 28888955 |
Synonyms | MIRN873, hsa-mir-873, MIR873 |
Description | Homo sapiens miR-873 stem-loop |
Comment | This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques . |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | ||||||||||||||||||||||
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Mature miRNA | hsa-miR-873-3p | |||||||||||||||||||||
Sequence | 46| GGAGACUGAUGAGUUCCCGGGA |67 | |||||||||||||||||||||
Evidence | Not_experimental | |||||||||||||||||||||
Experiments | ||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | TUFT1 | ||||||||||||||||||||
Synonyms | - | ||||||||||||||||||||
Description | tuftelin 1 | ||||||||||||||||||||
Transcript | NM_001126337 | ||||||||||||||||||||
Other Transcripts | NM_020127 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on TUFT1 | |||||||||||||||||||||
3'UTR of TUFT1 (miRNA target sites are highlighted) |
>TUFT1|NM_001126337|3'UTR 1 GCTGCCTGGAGATGGTTGCTGCCATTGCTGCTGCCTCTGCCTCGGAGAAGCCCACTGCCCCTGTTGGCTGTTAACACTGC 81 CTTTGACTTCCTGACTGTCCCCTGGCTGCACCCAGGACTTCGGGCTCCTGTGTCTCACCATTCCCAAGCCCCTGGCCACT 161 CTAAGCTGGGCAGACGGAGCACGAGCACCTATTCAAGGCACTGCAGCCCTTTGGAAGACATTGTCCTGCAAGCAGGAGCC 241 AGGGCAATATCTATATTCCTACAGTGACTATTTTTCTCTGTAGAGAGCCTCCCTTCTGTTGTAGACTGGACTCTGGCTGT 321 GCCATAAGCCAGGCCTTCATCAGATTGGGAGAGGTGACAAGATTTGCCTCAGCCCTAAAAGCTGGAGACACAGATGTCCA 401 GAGTGATTGGAGAATGTCCTGGGGGAATGAAGTTCCTTCCACAAACACAGCTCAGTTCTTAGCAACAAACTGTTTGTTTT 481 TCTACTTGCTCCATCTGCAGCCTACGCTGCCCTGGCCTCCTGCAGACAGATAGTGGGGTTACCTGGCAAGGCCTGGTGAG 561 AGCCAGTGAACCTAAGCTTTGACTGGGTGGCCTTGTCTTTCTGGGGAGGAGGGAATGTACATTCAGGGAGTAGCCTTTTG 641 CGGAAAAATTCTCTAGGGCTACAGACAGTCATGTGTGACTTCTCTCTGCTGTGAAAACTCCCAGAGTCTCTTTAGGGATT 721 TTCCCTAAGGTGTACCACCAGGCACACCTCAGTCTTCTTGACCCAGAGCCTGAAAACTGTTTTCACTGGGTTCCACCAGT 801 CCCAGCAAAATCCTCTTTGTATTTATTTTGCTAAGTTATTGGTGGTTTTGCTTACATCTCATGATTGATATAATACCAAA 881 GTTCTATAGCCTTCTCTTGCAGTATTTGGATTTGCTTGAAACCGGGAAAACTGTTCCCATTAGGCTTGTTAATGTCAGAG 961 TGACACTATTATGAATCTTTCTCTCCCTTTCCTCTGCCTGTTTCTTCTCTCTTTCTCCTTCAAACTTGCTCTGCAGCTAA 1041 GGAAGGTGAGTCTACTTTCCCTGAGGCTTTGGGGTCAGAGTATATGTTGTTTGGAGAAAGAGGGCAATCAGGACTCTTCT 1121 GGGACCCAGATGAGTTCTTCACTAGCCCTTCTGAACCCCTTGCTCCATAATTGGTCTTTTATCCTGGCTCTGAATGACCC 1201 TGCAGGTCATCATGGTTTTCTTTTTTTATTGTTTTTTTTTTTTTCTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAG 1281 TGCAGTGGCGCGATCTCAGCTCACTGCAACCTCTGCCTCCCGGATTTAAGCGATTCTTCTGCCTCAGCCTCCCGAGTAGC 1361 TGGGACTACAGGTGTGCCACCACGCCTGGCTGATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATACTGGCTAGGCT 1441 GGTCTCGAATTCCTGACCTCAGGTGATCCACCCACCTCGGCTTCCCAAAGTGCTAGGATTATAGGCTTGAGCTACTGCGC 1521 CCGGCCCATGGTGTTTTTCTTTAGGGCTCTTCCTACAACCTTGAGAAGTAGATAGGCATCAGAGTATGGTACTATAGGAA 1601 TCAGAAAAATTCAAAACAAATGTGGATTAAGTGTTTAGGCTCTATGTGGCTCACGCAGCCAGAATCCTTAAGTCTGTGTG 1681 TTTCTGTGTCTCAAGACTGGGCTCACATTCTGGCTTTGTCCATAACAATGCTCTGGGATTTCAGGGAGTTCCCTCATTTG 1761 TAAAATGAGGGGGTCAGAGCAGGTGATATCCATGTTTCTTCCCTTTCTGATATTGTTGTCTGTGGCATATTCTTTGTATG 1841 GCGAATTTAATAAATTATATTAATGTGTCTCTTTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 1921 AAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | Hela | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1048188. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_ptb_knockdown
... - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al. - Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
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CLIP-seq Support 1 for dataset GSM1048188 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | Hela / Hela_AGO2_CLIP_ptb_knockdown |
Location of target site | ENST00000368849.3 | 3UTR | UUCUGAGACAGAGUCUCACUCUGUCACCCAGGCUGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23313552 / GSE42701 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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108 hsa-miR-873-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT081178 | MIDN | midnolin | ![]() |
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2 | 4 | ||||||
MIRT109809 | ZFX | zinc finger protein, X-linked | ![]() |
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2 | 4 | ||||||
MIRT242383 | TMC5 | transmembrane channel like 5 | ![]() |
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2 | 4 | ||||||
MIRT444003 | METRN | meteorin, glial cell differentiation regulator | ![]() |
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2 | 4 | ||||||
MIRT444097 | SEPHS1 | selenophosphate synthetase 1 | ![]() |
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2 | 2 | ||||||
MIRT446158 | RPL12 | ribosomal protein L12 | ![]() |
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2 | 2 | ||||||
MIRT446859 | SAMD9L | sterile alpha motif domain containing 9 like | ![]() |
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2 | 2 | ||||||
MIRT447275 | FZD5 | frizzled class receptor 5 | ![]() |
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2 | 2 | ||||||
MIRT447391 | TMPRSS15 | transmembrane protease, serine 15 | ![]() |
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2 | 2 | ||||||
MIRT448817 | FKBP1A | FK506 binding protein 1A | ![]() |
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2 | 4 | ||||||
MIRT450582 | HIST1H2BG | histone cluster 1 H2B family member g | ![]() |
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2 | 2 | ||||||
MIRT451776 | USP36 | ubiquitin specific peptidase 36 | ![]() |
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2 | 2 | ||||||
MIRT457961 | ABCC5 | ATP binding cassette subfamily C member 5 | ![]() |
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2 | 4 | ||||||
MIRT458424 | KLHL38 | kelch like family member 38 | ![]() |
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2 | 4 | ||||||
MIRT461383 | SLFN12L | schlafen family member 12 like | ![]() |
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2 | 2 | ||||||
MIRT467793 | SLC2A14 | solute carrier family 2 member 14 | ![]() |
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2 | 2 | ||||||
MIRT476517 | GABRB1 | gamma-aminobutyric acid type A receptor beta1 subunit | ![]() |
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2 | 2 | ||||||
MIRT480290 | C7orf73 | short transmembrane mitochondrial protein 1 | ![]() |
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2 | 4 | ||||||
MIRT482745 | HES7 | hes family bHLH transcription factor 7 | ![]() |
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2 | 10 | ||||||
MIRT483189 | HIST1H2AH | histone cluster 1 H2A family member h | ![]() |
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2 | 6 | ||||||
MIRT486545 | DCTN4 | dynactin subunit 4 | ![]() |
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2 | 2 | ||||||
MIRT486581 | ZNF619 | zinc finger protein 619 | ![]() |
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2 | 2 | ||||||
MIRT492604 | POLR3E | RNA polymerase III subunit E | ![]() |
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2 | 2 | ||||||
MIRT494130 | DCAF7 | DDB1 and CUL4 associated factor 7 | ![]() |
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2 | 6 | ||||||
MIRT496023 | ZBED3 | zinc finger BED-type containing 3 | ![]() |
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2 | 2 | ||||||
MIRT497121 | NBEAL1 | neurobeachin like 1 | ![]() |
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2 | 2 | ||||||
MIRT497400 | TMEM245 | transmembrane protein 245 | ![]() |
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2 | 2 | ||||||
MIRT501410 | RANBP10 | RAN binding protein 10 | ![]() |
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2 | 2 | ||||||
MIRT510947 | PPTC7 | PTC7 protein phosphatase homolog | ![]() |
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2 | 6 | ||||||
MIRT512494 | ARID2 | AT-rich interaction domain 2 | ![]() |
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2 | 2 | ||||||
MIRT512595 | ZNF783 | zinc finger family member 783 | ![]() |
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2 | 2 | ||||||
MIRT512612 | CNTN4 | contactin 4 | ![]() |
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2 | 2 | ||||||
MIRT517808 | UGDH | UDP-glucose 6-dehydrogenase | ![]() |
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2 | 6 | ||||||
MIRT520686 | TMED7 | transmembrane p24 trafficking protein 7 | ![]() |
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2 | 4 | ||||||
MIRT526179 | HEPH | hephaestin | ![]() |
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2 | 2 | ||||||
MIRT532568 | CSTF1 | cleavage stimulation factor subunit 1 | ![]() |
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2 | 2 | ||||||
MIRT533979 | TADA2A | transcriptional adaptor 2A | ![]() |
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2 | 2 | ||||||
MIRT538622 | CCSER2 | coiled-coil serine rich protein 2 | ![]() |
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2 | 4 | ||||||
MIRT539703 | EIF3H | eukaryotic translation initiation factor 3 subunit H | ![]() |
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2 | 2 | ||||||
MIRT539806 | GAPVD1 | GTPase activating protein and VPS9 domains 1 | ![]() |
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2 | 2 | ||||||
MIRT540422 | FAM83F | family with sequence similarity 83 member F | ![]() |
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2 | 2 | ||||||
MIRT540506 | CXCL10 | C-X-C motif chemokine ligand 10 | ![]() |
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2 | 2 | ||||||
MIRT540619 | F2RL2 | coagulation factor II thrombin receptor like 2 | ![]() |
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2 | 2 | ||||||
MIRT542423 | ZNF331 | zinc finger protein 331 | ![]() |
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2 | 2 | ||||||
MIRT542454 | AKR7A2 | aldo-keto reductase family 7 member A2 | ![]() |
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2 | 2 | ||||||
MIRT543383 | CC2D2A | coiled-coil and C2 domain containing 2A | ![]() |
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2 | 2 | ||||||
MIRT544777 | CSTF2T | cleavage stimulation factor subunit 2 tau variant | ![]() |
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2 | 4 | ||||||
MIRT544923 | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit | ![]() |
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2 | 2 | ||||||
MIRT549768 | ZNF611 | zinc finger protein 611 | ![]() |
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2 | 4 | ||||||
MIRT551242 | COLEC10 | collectin subfamily member 10 | ![]() |
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2 | 2 | ||||||
MIRT560474 | ENSA | endosulfine alpha | ![]() |
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2 | 2 | ||||||
MIRT569738 | GPR173 | G protein-coupled receptor 173 | ![]() |
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2 | 2 | ||||||
MIRT571297 | CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | ![]() |
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2 | 2 | ||||||
MIRT572345 | CKAP2L | cytoskeleton associated protein 2 like | ![]() |
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2 | 2 | ||||||
MIRT573112 | ERBB2IP | erbb2 interacting protein | ![]() |
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2 | 2 | ||||||
MIRT607744 | ANGPT4 | angiopoietin 4 | ![]() |
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2 | 2 | ||||||
MIRT607903 | SPRYD4 | SPRY domain containing 4 | ![]() |
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2 | 2 | ||||||
MIRT611744 | SERPING1 | serpin family G member 1 | ![]() |
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2 | 4 | ||||||
MIRT615101 | BNC2 | basonuclin 2 | ![]() |
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2 | 2 | ||||||
MIRT619124 | CD40LG | CD40 ligand | ![]() |
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2 | 2 | ||||||
MIRT625572 | ANKRD42 | ankyrin repeat domain 42 | ![]() |
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2 | 2 | ||||||
MIRT629038 | KLLN | killin, p53-regulated DNA replication inhibitor | ![]() |
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2 | 2 | ||||||
MIRT633986 | SLC35E2 | solute carrier family 35 member E2 | ![]() |
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2 | 2 | ||||||
MIRT635675 | COX18 | COX18, cytochrome c oxidase assembly factor | ![]() |
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2 | 4 | ||||||
MIRT637471 | DEFB105B | defensin beta 105B | ![]() |
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2 | 4 | ||||||
MIRT637503 | DEFB105A | defensin beta 105A | ![]() |
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2 | 4 | ||||||
MIRT639735 | MAP2K2 | mitogen-activated protein kinase kinase 2 | ![]() |
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2 | 2 | ||||||
MIRT640730 | C9orf64 | chromosome 9 open reading frame 64 | ![]() |
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2 | 2 | ||||||
MIRT645364 | C9orf47 | chromosome 9 open reading frame 47 | ![]() |
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2 | 2 | ||||||
MIRT647938 | RNF152 | ring finger protein 152 | ![]() |
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2 | 2 | ||||||
MIRT649400 | SH2D4A | SH2 domain containing 4A | ![]() |
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2 | 2 | ||||||
MIRT656860 | KIN | Kin17 DNA and RNA binding protein | ![]() |
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2 | 2 | ||||||
MIRT663470 | POFUT2 | protein O-fucosyltransferase 2 | ![]() |
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2 | 2 | ||||||
MIRT663507 | NKAPL | NFKB activating protein like | ![]() |
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2 | 4 | ||||||
MIRT667690 | KNSTRN | kinetochore localized astrin/SPAG5 binding protein | ![]() |
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2 | 2 | ||||||
MIRT677403 | PCNP | PEST proteolytic signal containing nuclear protein | ![]() |
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2 | 2 | ||||||
MIRT678682 | SCUBE3 | signal peptide, CUB domain and EGF like domain containing 3 | ![]() |
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2 | 2 | ||||||
MIRT678789 | NUPL2 | nucleoporin like 2 | ![]() |
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2 | 2 | ||||||
MIRT680649 | KIAA1456 | KIAA1456 | ![]() |
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2 | 2 | ||||||
MIRT682450 | MTX3 | metaxin 3 | ![]() |
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2 | 2 | ||||||
MIRT682740 | CA6 | carbonic anhydrase 6 | ![]() |
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2 | 2 | ||||||
MIRT684421 | TUFT1 | tuftelin 1 | ![]() |
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2 | 2 | ||||||
MIRT690535 | TRAPPC2 | trafficking protein particle complex 2 | ![]() |
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2 | 2 | ||||||
MIRT690595 | C17orf105 | chromosome 17 open reading frame 105 | ![]() |
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2 | 2 | ||||||
MIRT690771 | PLA2G2C | phospholipase A2 group IIC | ![]() |
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2 | 2 | ||||||
MIRT692233 | ALDH1B1 | aldehyde dehydrogenase 1 family member B1 | ![]() |
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2 | 2 | ||||||
MIRT693667 | MXRA7 | matrix remodeling associated 7 | ![]() |
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2 | 2 | ||||||
MIRT695551 | CLPB | ClpB homolog, mitochondrial AAA ATPase chaperonin | ![]() |
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2 | 2 | ||||||
MIRT695870 | C19orf52 | translocase of inner mitochondrial membrane 29 | ![]() |
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2 | 2 | ||||||
MIRT696214 | LYZ | lysozyme | ![]() |
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2 | 2 | ||||||
MIRT698368 | TMED4 | transmembrane p24 trafficking protein 4 | ![]() |
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2 | 2 | ||||||
MIRT700795 | PHTF2 | putative homeodomain transcription factor 2 | ![]() |
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2 | 2 | ||||||
MIRT701640 | MYLK3 | myosin light chain kinase 3 | ![]() |
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2 | 2 | ||||||
MIRT702989 | HERPUD2 | HERPUD family member 2 | ![]() |
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2 | 2 | ||||||
MIRT703627 | FBXL3 | F-box and leucine rich repeat protein 3 | ![]() |
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2 | 2 | ||||||
MIRT703783 | FAM102B | family with sequence similarity 102 member B | ![]() |
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2 | 2 | ||||||
MIRT704293 | DDX19B | DEAD-box helicase 19B | ![]() |
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2 | 2 | ||||||
MIRT704828 | CDC73 | cell division cycle 73 | ![]() |
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2 | 2 | ||||||
MIRT705014 | CAMK2N1 | calcium/calmodulin dependent protein kinase II inhibitor 1 | ![]() |
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2 | 2 | ||||||
MIRT708480 | OLR1 | oxidized low density lipoprotein receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT710770 | PHF7 | PHD finger protein 7 | ![]() |
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2 | 2 | ||||||
MIRT718918 | TRIM66 | tripartite motif containing 66 | ![]() |
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2 | 2 | ||||||
MIRT720390 | ZNF549 | zinc finger protein 549 | ![]() |
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2 | 2 | ||||||
MIRT720593 | TTC39C | tetratricopeptide repeat domain 39C | ![]() |
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2 | 2 | ||||||
MIRT723515 | SIGLEC8 | sialic acid binding Ig like lectin 8 | ![]() |
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2 | 2 | ||||||
MIRT724458 | PRKX | protein kinase, X-linked | ![]() |
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2 | 2 | ||||||
MIRT737267 | UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | ![]() |
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3 | 0 | |||||
MIRT737356 | ZIC2 | Zic family member 2 | ![]() |
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4 | 0 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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