miRTarBase - #MIRT684841


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pre-miRNA Information
pre-miRNA hsa-mir-758   
Genomic Coordinates chr14: 101026020 - 101026107
Synonyms MIRN758, hsa-mir-758, MIR758
Description Homo sapiens miR-758 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-758-5p
Sequence 15| GAUGGUUGACCAGAGAGCACAC |36
Evidence Experimental
Experiments SOLiD
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 16 14 + 101026049 29233923 MiREDiBase
A-to-I 21 14 + 101026054 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372417522 1 dbSNP
rs748092616 2 dbSNP
rs1270901332 4 dbSNP
rs1364206491 5 dbSNP
rs1483583954 8 dbSNP
rs770931807 10 dbSNP
rs776760808 11 dbSNP
rs1360350664 12 dbSNP
rs759742151 13 dbSNP
rs1002938972 15 dbSNP
rs770107042 17 dbSNP
rs369242818 20 dbSNP
rs1217090272 21 dbSNP
rs763341052 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TPGS2   
Synonyms C18orf10, HMFN0601, L17, PGs2
Description tubulin polyglutamylase complex subunit 2
Transcript NM_015476   
Expression
Putative miRNA Targets on TPGS2
3'UTR of TPGS2
(miRNA target sites are highlighted)		 
>TPGS2|NM_015476|3'UTR
   1 GCACCCCTCCCTCCAACTCCCTACCAGCTCCAGAGTGGTGGTTTCCATGCACAGATGGCCCTAGGGGTGACCTCCAGTTT
  81 TGCGTGTGGACCGTAGGCCTCTTTCTAGTTGAATGACCAAAATTGTAAGGCTTTTAGTCCCACCGACATTAGCCAGGCTC
 161 GTAGTGAGGCCTCCAGAGCAGGTTGTGCTGTCCCCTGCCTCTGGAAGCAATGGGGAATTTGGAATCTTGTGTAAGTGCCC
 241 AAATAAGTCTGAGTGCTTTCCTCTTCTTCAACACTCAACCCTCAATCCCTTAGCACTGATTGATTAGAGAGGTCCCCCAA
 321 AGAAACCACTGGTTTTGACCCATGAAGCATTAGAACTGCATTGTTCATTCAGGAGCCACTAGTCACATATGACTATTTAA
 401 ATTTAAAGTAAATTGTATGAAAAATTCATTTCTTCAATTGCATTAGCCACATTTTGAGTATTCATGTGGCTGGTAGATTC
 481 TGTATTAGCACAAAGATATGGAACATTTCCATCACCACAGAAAGTTCTGTTGGACAGCACTGCATTAGAATATTTTCATA
 561 CTGCTCTTCCTCAATTAATTTTTGTTGTTAATGTTGATGTCTTCATTGGATGGGTCATAATGTTCCATGAAACCTCTCAA
 641 GTACACAATTGTATGTTCTTTGTATCCCTTACCACAAATATCTCGCTCTGCTCATTTCTTTTGCAGCTTCCTATAAAGTT
 721 TGTCTTCCTCATCAGTTTCCAGTGAAGTTTCTTGCTTCCAGTTTTGTGTTATGATGTTTGTACACGTTCCACAATTATCT
 801 TCCTTATTAACTTTTTAAAGAAGGTGTACTTCTGCTATACTTTATTCTTACCATTTAAAAACAAAAAATTCCCAAACATT
 881 GTTTTGCACAACTCTTCATAAAGAAAGAGTTTTAATGGTGCCAGACACTGTTAACAGAAGCTTTCCACCTGCTCTGCCTG
 961 CCTCTTCACAGCTCTGAGTTGTCCAGCCTCACTTTGCCTGGTCCCTGGCCATCCTTAGGACAAGCAGTCTCCTGCTTAGA
1041 ACAGGGTGGGCTTCCAAGAGTTCCTTTGGAAGCAAGTTGCCTGTAATTCAGAAATCATTTTCCCATTGACATATGGGGGA
1121 ACCTCTAGCCCACATATGCTTAATATTTGACACAAGATAAATCTGACATACCTACTACATTTAATGAAATTTTTACAGAG
1201 AAGGTTGCTCAGATTTTCAATTAGGAATGCCTATTTATTTCCTCCCTCTACAGTCCTGGCTGTGGGCAGAAGCAAGGCCT
1281 TCACCCTGCTTCCCAACAGGGAAAGTGGGGAGTCACCCACCTAGCCCCAAGTTCTTTGGGTGGCTGCAGTTTTTGTACTG
1361 AAGTCCCAGAGGTTAGAGAATTAGGAGTTTTGAGGAATGAGGTGCAGGGGCCTCTACCATCTGCACACTTCAGTCCCAGC
1441 TGGCTCATTCTCTTTCCTGACTTCTCTCTACCCCGGTGATTGGCCAGACTTCCTTCCTTTGCACTGTCTACCTGCTAATC
1521 GACCCAGGGTTTCCCTCTTCCAAACCCACTGGGGAACTAAGAGCAGTCCACAGGATTCTCCACATGCACTTTTGCTCTGA
1601 AACATGTTTATTTTGATTGTTGACAATAGTGATAGATATTCATGAGAAAGCGCCTTCGATATCTCCTCCACCTACCACTT
1681 TCCATAGCCCCTGAGGAAAACCAAGGTGAAGAGTTAGCCTTCAAGGATCAGGGCAAGCTCTAACTGGCTGCTTCCCCATA
1761 TTTGTAATAGTTCAAAGTCTTGAAATATCAGCGCTTAAGAGTCTTTGGGAGCATAAACTGAGCTTCGTATTAACAGCTTC
1841 TTCATTTGCTTTAAAATAGCGAGACCTCTTACCTTTTCAATCCCAAAACTAACCACTTATAATTCAGTGTGGTCATTTAA
1921 ACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTTAACCATAACATGACTGTCACATATT
2001 CTCTAGGAGACATTTTGGCCCTTTTAGTTGTTTAGGTTATTATACTTCAAGGATTTATAAATGTGCAACAATTCATGGAG
2081 TGGCAGAAAAGGATATAGAGAGACCAAGTTGTTGAGGACAATAGCTGGAGTTTAGTCTTCCAGAAGTATTTTTCTTGCCA
2161 GAATTGATCAAAGGAAGAGCCAACGGCACTGGATAGGAGATTCTAGCATTTGGCTGCTTCTCCAAGACAAGCGAGGTTAG
2241 AAGGGAGTTGAGAAGTTATGTCATCTTCCACTGCAGCAGATACCCCTTTTTTAGTACTTGGAGATCCCCCGAATCACAGC
2321 ATTTCTAAATCAGCCCTGGATTCCACAAGTGAAGCAGCGGAGGAACCAGGAGGTCAGCGGTGTCACTCAAATCTGTGGCA
2401 ATCAAGTGGGAGTTCTCAAAAGGCTATCAAAGGAAGGGGGTTATGATAAGGAAAGGCTCAAGACCTGCCTCAGAAGGAGT
2481 GAGCAGGGAAGAGCAGGACTGACTCCACTCAGTGCAGGATCCAGTACAAAATGAAGATGTGAGGCTTTTGTGCAAACAGC
2561 AGGAAAACATTACCTTTACAGGTACTAAAATGTAATGTTTTTCCTTTCTTCCATAGTGTCTTTCTCAACTTGTTATGGCT
2641 GTGTTTTTTATTTGCTACTTAATGCTGTTCTAACTAAAAACTTAAATGTTAAATTCCTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' caCACG-AGAGAC-CAGUUGGUAg 5'
            |||: | | ||  |:|||||| 
Target 5' gtGTGTGTGTGTGTTTTAACCATa 3'
 1959 - 1982 140.00 -14.40
2 
miRNA  3' caCAC---GAG---AGAC-CAGUUGGUag 5'
            |||   |||   |||| | |||:||  
Target 5' cgGTGTCACTCAAATCTGTGGCAATCAag 3'
 2378 - 2406 124.00 -13.60
3 
miRNA  3' caCACGA---GAGA--------CCAGUUGGUAg 5'
            |||||   ||||          |||||| | 
Target 5' gaGTGCTTTCCTCTTCTTCAACACTCAACCCTc 3'
 251 - 283 118.00 -15.03
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31502693 30 COSMIC
COSN20114926 31 COSMIC
COSN30103348 35 COSMIC
COSN31494263 65 COSMIC
COSN26999455 69 COSMIC
COSN30504152 91 COSMIC
COSN30450822 92 COSMIC
COSN507232 92 COSMIC
COSN31552991 226 COSMIC
COSN20093424 665 COSMIC
COSN25278133 665 COSMIC
COSN5223103 1793 COSMIC
COSN7357009 1980 COSMIC
COSN5845133 2667 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1171911503 6 dbSNP
rs1393799398 8 dbSNP
rs1166717173 11 dbSNP
rs1423202745 12 dbSNP
rs1475409534 13 dbSNP
rs1401574985 14 dbSNP
rs1410466085 15 dbSNP
rs1416944724 15 dbSNP
rs749696017 17 dbSNP
rs756190391 18 dbSNP
rs1372811321 23 dbSNP
rs11558282 24 dbSNP
rs750474443 26 dbSNP
rs1352579272 30 dbSNP
rs34680547 33 dbSNP
rs761786697 37 dbSNP
rs751347785 41 dbSNP
rs780431836 42 dbSNP
rs756425742 47 dbSNP
rs750624727 48 dbSNP
rs1273004234 50 dbSNP
rs1303854213 54 dbSNP
rs1372797829 60 dbSNP
rs1231620923 65 dbSNP
rs941743011 67 dbSNP
rs910271610 73 dbSNP
rs1456799368 74 dbSNP
rs1198468500 75 dbSNP
rs538484278 83 dbSNP
rs185748941 84 dbSNP
rs932945449 91 dbSNP
rs900344703 93 dbSNP
rs1037545864 98 dbSNP
rs977640500 100 dbSNP
rs1437344224 105 dbSNP
rs1326408493 107 dbSNP
rs552705984 114 dbSNP
rs532690667 123 dbSNP
rs946336011 124 dbSNP
rs941974147 127 dbSNP
rs1197788638 136 dbSNP
rs990299453 137 dbSNP
rs1326534224 139 dbSNP
rs140061772 144 dbSNP
rs1048222740 145 dbSNP
rs1247225542 149 dbSNP
rs547061417 161 dbSNP
rs1278319627 168 dbSNP
rs1442063524 169 dbSNP
rs917985791 173 dbSNP
rs1335840934 174 dbSNP
rs1337331169 182 dbSNP
rs1208307993 190 dbSNP
rs371523887 192 dbSNP
rs567588358 197 dbSNP
rs561292697 199 dbSNP
rs971803394 200 dbSNP
rs11660414 203 dbSNP
rs1163801464 210 dbSNP
rs1426338542 214 dbSNP
rs1165492698 226 dbSNP
rs1419791182 229 dbSNP
rs897770408 231 dbSNP
rs925476449 236 dbSNP
rs1385278384 237 dbSNP
rs531605189 243 dbSNP
rs979706324 258 dbSNP
rs1339192051 270 dbSNP
rs1399945598 272 dbSNP
rs1294391887 274 dbSNP
rs1357883348 274 dbSNP
rs1243134995 276 dbSNP
rs1265213192 282 dbSNP
rs967387998 285 dbSNP
rs562557207 300 dbSNP
rs912882901 301 dbSNP
rs1470438007 302 dbSNP
rs35655876 303 dbSNP
rs1188617168 306 dbSNP
rs149494703 306 dbSNP
rs547786977 306 dbSNP
rs61405145 306 dbSNP
rs34245648 307 dbSNP
rs988853757 317 dbSNP
rs142659108 319 dbSNP
rs796112930 319 dbSNP
rs576557092 323 dbSNP
rs1364152205 334 dbSNP
rs1455027687 339 dbSNP
rs933124042 340 dbSNP
rs553442180 341 dbSNP
rs1359370762 350 dbSNP
rs954395820 364 dbSNP
rs1489870789 368 dbSNP
rs901497813 371 dbSNP
rs1314157343 378 dbSNP
rs1268512493 385 dbSNP
rs1041391046 390 dbSNP
rs560860897 408 dbSNP
rs1241480496 413 dbSNP
rs1307302352 413 dbSNP
rs1353217187 415 dbSNP
rs150890708 416 dbSNP
rs1282543041 424 dbSNP
rs990373512 426 dbSNP
rs141571838 427 dbSNP
rs964504814 432 dbSNP
rs180864631 437 dbSNP
rs927526044 447 dbSNP
rs1454438926 452 dbSNP
rs981928315 456 dbSNP
rs575405612 463 dbSNP
rs1356868347 472 dbSNP
rs538174782 474 dbSNP
rs575880317 475 dbSNP
rs1402609815 492 dbSNP
rs1344267708 493 dbSNP
rs558915402 496 dbSNP
rs1006126352 498 dbSNP
rs886328624 499 dbSNP
rs1329696902 503 dbSNP
rs375807393 511 dbSNP
rs567009745 526 dbSNP
rs1305720341 533 dbSNP
rs563502394 534 dbSNP
rs1366004262 539 dbSNP
rs1013967556 540 dbSNP
rs759944230 541 dbSNP
rs1158179321 548 dbSNP
rs962718837 549 dbSNP
rs1481556460 550 dbSNP
rs1016155760 557 dbSNP
rs1410120658 558 dbSNP
rs1006139538 569 dbSNP
rs1468646273 570 dbSNP
rs1170720340 571 dbSNP
rs1195054768 581 dbSNP
rs1422477579 590 dbSNP
rs1432053832 596 dbSNP
rs1170499738 600 dbSNP
rs1374194248 605 dbSNP
rs547122121 613 dbSNP
rs1028857269 617 dbSNP
rs1329810318 622 dbSNP
rs997658790 638 dbSNP
rs901624229 640 dbSNP
rs60262053 651 dbSNP
rs189201442 652 dbSNP
rs1386321756 655 dbSNP
rs1296371392 665 dbSNP
rs892808185 675 dbSNP
rs567572488 677 dbSNP
rs1216651426 680 dbSNP
rs1257205227 684 dbSNP
rs1200421351 685 dbSNP
rs1215214353 687 dbSNP
rs1490886338 689 dbSNP
rs1240566061 693 dbSNP
rs1215608519 694 dbSNP
rs183977749 698 dbSNP
rs1487943194 703 dbSNP
rs927440692 707 dbSNP
rs1286978214 712 dbSNP
rs148366706 719 dbSNP
rs1479089653 731 dbSNP
rs1169087264 735 dbSNP
rs1423382029 741 dbSNP
rs1322219407 747 dbSNP
rs774810717 751 dbSNP
rs771435380 761 dbSNP
rs1283300827 766 dbSNP
rs1457591868 770 dbSNP
rs1289529111 774 dbSNP
rs1342386734 775 dbSNP
rs1224803068 777 dbSNP
rs1277446025 782 dbSNP
rs1045925506 784 dbSNP
rs531540260 785 dbSNP
rs562779095 786 dbSNP
rs1287890365 788 dbSNP
rs879457620 793 dbSNP
rs1431263567 806 dbSNP
rs1215976064 807 dbSNP
rs754009451 810 dbSNP
rs925425359 811 dbSNP
rs1261829017 816 dbSNP
rs972822086 818 dbSNP
rs1263149115 824 dbSNP
rs551994565 826 dbSNP
rs945578453 829 dbSNP
rs532186810 830 dbSNP
rs1160042966 832 dbSNP
rs1362576335 833 dbSNP
rs144394450 837 dbSNP
rs1417690041 843 dbSNP
rs1297636163 847 dbSNP
rs1186096881 854 dbSNP
rs1475962490 862 dbSNP
rs1244126264 866 dbSNP
rs936318316 878 dbSNP
rs1029225464 879 dbSNP
rs1378095591 879 dbSNP
rs954342681 879 dbSNP
rs922972877 885 dbSNP
rs1202338871 891 dbSNP
rs1461308983 908 dbSNP
rs1215319749 909 dbSNP
rs997335776 909 dbSNP
rs1205057491 914 dbSNP
rs974460245 917 dbSNP
rs773358199 920 dbSNP
rs964460603 922 dbSNP
rs1019956488 923 dbSNP
rs1212787248 933 dbSNP
rs1236108347 937 dbSNP
rs1009981782 946 dbSNP
rs902280905 947 dbSNP
rs892796867 948 dbSNP
rs1382454511 958 dbSNP
rs1438053676 960 dbSNP
rs1016030782 976 dbSNP
rs1363821052 983 dbSNP
rs769844258 987 dbSNP
rs1002174950 992 dbSNP
rs906093442 994 dbSNP
rs1358394338 995 dbSNP
rs1046419885 997 dbSNP
rs539962834 1003 dbSNP
rs950164755 1011 dbSNP
rs1406829770 1013 dbSNP
rs1238892185 1016 dbSNP
rs950585207 1025 dbSNP
rs1346446559 1033 dbSNP
rs766541493 1038 dbSNP
rs1221465535 1046 dbSNP
rs1277174472 1053 dbSNP
rs1026615893 1060 dbSNP
rs1352793862 1062 dbSNP
rs1442332171 1065 dbSNP
rs1013544008 1072 dbSNP
rs896486720 1079 dbSNP
rs1456611327 1081 dbSNP
rs941458348 1082 dbSNP
rs574442195 1100 dbSNP
rs1395788202 1118 dbSNP
rs909868900 1125 dbSNP
rs1424435566 1144 dbSNP
rs1410451052 1146 dbSNP
rs1055155325 1147 dbSNP
rs1429276336 1149 dbSNP
rs1397779282 1151 dbSNP
rs1445610580 1159 dbSNP
rs1326117720 1164 dbSNP
rs1332434643 1165 dbSNP
rs985498786 1170 dbSNP
rs1273724446 1172 dbSNP
rs1002274995 1174 dbSNP
rs1219710578 1179 dbSNP
rs748437787 1187 dbSNP
rs1260408798 1196 dbSNP
rs1316390701 1197 dbSNP
rs1198281705 1199 dbSNP
rs1470568206 1203 dbSNP
rs191844066 1204 dbSNP
rs976411252 1209 dbSNP
rs544175152 1210 dbSNP
rs1182201755 1219 dbSNP
rs1421250202 1220 dbSNP
rs1464943803 1222 dbSNP
rs1165355731 1224 dbSNP
rs142738592 1227 dbSNP
rs1403242532 1232 dbSNP
rs1322313771 1234 dbSNP
rs1244345304 1237 dbSNP
rs1020109679 1239 dbSNP
rs1043835383 1240 dbSNP
rs1280600507 1246 dbSNP
rs945496581 1250 dbSNP
rs1218461021 1251 dbSNP
rs1266387546 1266 dbSNP
rs1358820090 1276 dbSNP
rs11659465 1281 dbSNP
rs1289273230 1283 dbSNP
rs1488635366 1284 dbSNP
rs527839914 1285 dbSNP
rs1204795513 1302 dbSNP
rs1308950978 1305 dbSNP
rs1477449034 1307 dbSNP
rs1188477233 1312 dbSNP
rs957142633 1316 dbSNP
rs1162224188 1334 dbSNP
rs745721648 1334 dbSNP
rs1385087425 1348 dbSNP
rs541105842 1356 dbSNP
rs1295785986 1364 dbSNP
rs1359248381 1364 dbSNP
rs573474960 1367 dbSNP
rs1383234132 1372 dbSNP
rs1317111989 1376 dbSNP
rs1389534072 1384 dbSNP
rs922920577 1387 dbSNP
rs1270124693 1391 dbSNP
rs757229695 1392 dbSNP
rs1354659782 1400 dbSNP
rs905535564 1401 dbSNP
rs138228502 1402 dbSNP
rs1487926755 1406 dbSNP
rs1372684499 1407 dbSNP
rs1161877610 1410 dbSNP
rs1014553448 1411 dbSNP
rs1186538303 1417 dbSNP
rs1386210272 1419 dbSNP
rs1441141633 1421 dbSNP
rs1156373051 1433 dbSNP
rs1419639123 1440 dbSNP
rs943058487 1450 dbSNP
rs1404941550 1455 dbSNP
rs1394706547 1456 dbSNP
rs908917618 1456 dbSNP
rs1250418353 1458 dbSNP
rs1242503923 1462 dbSNP
rs555333686 1463 dbSNP
rs984567754 1464 dbSNP
rs1483734750 1466 dbSNP
rs1266395359 1468 dbSNP
rs867106883 1471 dbSNP
rs372880605 1474 dbSNP
rs1238555745 1475 dbSNP
rs537350326 1475 dbSNP
rs888515384 1478 dbSNP
rs1236590935 1483 dbSNP
rs1237066556 1490 dbSNP
rs774343532 1492 dbSNP
rs567733520 1493 dbSNP
rs1177578871 1494 dbSNP
rs992058657 1497 dbSNP
rs1050284045 1501 dbSNP
rs1316332191 1501 dbSNP
rs1307578885 1502 dbSNP
rs524926 1503 dbSNP
rs1449313996 1504 dbSNP
rs922595766 1505 dbSNP
rs1376393902 1513 dbSNP
rs537449278 1514 dbSNP
rs976019162 1517 dbSNP
rs1033608097 1518 dbSNP
rs1303481093 1520 dbSNP
rs1232357130 1521 dbSNP
rs752324965 1522 dbSNP
rs1258481426 1524 dbSNP
rs903856087 1529 dbSNP
rs1404493220 1541 dbSNP
rs1196495884 1548 dbSNP
rs1257087826 1550 dbSNP
rs1022765867 1560 dbSNP
rs1366596660 1561 dbSNP
rs1264578597 1564 dbSNP
rs1431963634 1565 dbSNP
rs767198325 1581 dbSNP
rs368358597 1584 dbSNP
rs1009686135 1588 dbSNP
rs1424830107 1610 dbSNP
rs944655892 1615 dbSNP
rs1168952129 1618 dbSNP
rs544408612 1620 dbSNP
rs1458599968 1622 dbSNP
rs1295363899 1629 dbSNP
rs1452077754 1633 dbSNP
rs1278812301 1634 dbSNP
rs913050279 1634 dbSNP
rs1216634769 1635 dbSNP
rs988581478 1638 dbSNP
rs1032730415 1639 dbSNP
rs957217424 1639 dbSNP
rs1263198259 1641 dbSNP
rs1487852534 1650 dbSNP
rs1216659848 1651 dbSNP
rs755334102 1652 dbSNP
rs1479079794 1653 dbSNP
rs1473301982 1657 dbSNP
rs751981137 1658 dbSNP
rs1198250182 1659 dbSNP
rs934175663 1672 dbSNP
rs1424627608 1673 dbSNP
rs571511583 1681 dbSNP
rs1269011927 1682 dbSNP
rs552057545 1707 dbSNP
rs969749649 1709 dbSNP
rs187394376 1710 dbSNP
rs1362455163 1714 dbSNP
rs1024424240 1716 dbSNP
rs1261263606 1718 dbSNP
rs1379567352 1721 dbSNP
rs1241045844 1726 dbSNP
rs756131832 1728 dbSNP
rs559933485 1732 dbSNP
rs908912852 1734 dbSNP
rs1310195060 1737 dbSNP
rs750333796 1739 dbSNP
rs184470716 1741 dbSNP
rs1240308976 1746 dbSNP
rs766740962 1755 dbSNP
rs1287533057 1777 dbSNP
rs1346464062 1777 dbSNP
rs1489558691 1785 dbSNP
rs773130142 1788 dbSNP
rs897432504 1791 dbSNP
rs529781280 1792 dbSNP
rs919073310 1798 dbSNP
rs1384644135 1799 dbSNP
rs991961810 1801 dbSNP
rs1005694363 1806 dbSNP
rs1459228383 1825 dbSNP
rs1404516136 1826 dbSNP
rs561037190 1827 dbSNP
rs888620021 1829 dbSNP
rs960547870 1830 dbSNP
rs570224312 1836 dbSNP
rs1300847586 1844 dbSNP
rs192956251 1853 dbSNP
rs1446976191 1858 dbSNP
rs189039027 1860 dbSNP
rs980691410 1861 dbSNP
rs1284227791 1869 dbSNP
rs1212765467 1871 dbSNP
rs1313284189 1871 dbSNP
rs1041048868 1875 dbSNP
rs564819615 1876 dbSNP
rs1461050278 1885 dbSNP
rs148470392 1892 dbSNP
rs545736041 1893 dbSNP
rs1437952199 1896 dbSNP
rs1158049308 1899 dbSNP
rs1262084319 1900 dbSNP
rs968443314 1900 dbSNP
rs11665141 1903 dbSNP
rs1173696426 1905 dbSNP
rs553637720 1907 dbSNP
rs543220611 1912 dbSNP
rs1447088051 1922 dbSNP
rs935812312 1923 dbSNP
rs1203159097 1924 dbSNP
rs1274923989 1925 dbSNP
rs892579451 1925 dbSNP
rs1029721492 1926 dbSNP
rs1368924829 1926 dbSNP
rs1276854988 1927 dbSNP
rs796404750 1927 dbSNP
rs1261689487 1928 dbSNP
rs756602437 1929 dbSNP
rs1225471789 1930 dbSNP
rs1202584861 1937 dbSNP
rs998271048 1939 dbSNP
rs1459724051 1941 dbSNP
rs1437716424 1945 dbSNP
rs1265349390 1953 dbSNP
rs1260295081 1955 dbSNP
rs1404581935 1957 dbSNP
rs1336621513 1963 dbSNP
rs1469887042 1964 dbSNP
rs1181261087 1969 dbSNP
rs1403669986 1971 dbSNP
rs34376326 1972 dbSNP
rs1172527470 1973 dbSNP
rs1177532015 1973 dbSNP
rs1189348200 1973 dbSNP
rs1195383441 1973 dbSNP
rs1228277545 1973 dbSNP
rs1235043584 1973 dbSNP
rs1323662426 1973 dbSNP
rs1324908163 1973 dbSNP
rs1337698030 1973 dbSNP
rs1351069905 1973 dbSNP
rs1397755828 1973 dbSNP
rs1403150565 1973 dbSNP
rs1439263364 1973 dbSNP
rs1458945417 1973 dbSNP
rs1465981686 1973 dbSNP
rs1478974105 1973 dbSNP
rs200978123 1973 dbSNP
rs368627648 1973 dbSNP
rs373804795 1973 dbSNP
rs374016158 1973 dbSNP
rs398032495 1973 dbSNP
rs60958340 1973 dbSNP
rs925820052 1975 dbSNP
rs35302949 1976 dbSNP
rs1365582636 1977 dbSNP
rs900021184 1979 dbSNP
rs1401075540 1980 dbSNP
rs574096678 1988 dbSNP
rs499429 1989 dbSNP
rs1325002546 1993 dbSNP
rs1373275573 2001 dbSNP
rs970239176 2004 dbSNP
rs941661427 2009 dbSNP
rs1285048776 2010 dbSNP
rs1023953865 2014 dbSNP
rs762020582 2015 dbSNP
rs992467716 2025 dbSNP
rs961045216 2036 dbSNP
rs1218638437 2048 dbSNP
rs145681305 2055 dbSNP
rs1446251302 2057 dbSNP
rs1187969497 2059 dbSNP
rs1048748977 2065 dbSNP
rs1005808719 2070 dbSNP
rs776985382 2072 dbSNP
rs928978265 2078 dbSNP
rs1443110560 2093 dbSNP
rs1280749406 2095 dbSNP
rs781360731 2097 dbSNP
rs566239574 2102 dbSNP
rs1420864030 2104 dbSNP
rs918988441 2105 dbSNP
rs1194133174 2111 dbSNP
rs1160934180 2131 dbSNP
rs1383401857 2137 dbSNP
rs1382064340 2138 dbSNP
rs140625184 2140 dbSNP
rs1342490331 2141 dbSNP
rs1450647694 2142 dbSNP
rs1314486718 2148 dbSNP
rs138032305 2149 dbSNP
rs1354450986 2154 dbSNP
rs1028939720 2161 dbSNP
rs996923246 2164 dbSNP
rs1275579866 2173 dbSNP
rs901230973 2180 dbSNP
rs1200886942 2183 dbSNP
rs1041123588 2184 dbSNP
rs150360332 2185 dbSNP
rs370777538 2193 dbSNP
rs926474617 2204 dbSNP
rs538585073 2216 dbSNP
rs968013927 2222 dbSNP
rs915213140 2226 dbSNP
rs566410649 2232 dbSNP
rs546437542 2233 dbSNP
rs892470968 2235 dbSNP
rs988136478 2236 dbSNP
rs529891637 2238 dbSNP
rs1404741288 2255 dbSNP
rs1468460297 2256 dbSNP
rs935952237 2257 dbSNP
rs1377895550 2258 dbSNP
rs925794782 2260 dbSNP
rs1304947630 2261 dbSNP
rs1326349230 2265 dbSNP
rs567306797 2281 dbSNP
rs1233814994 2283 dbSNP
rs550652027 2287 dbSNP
rs1044642845 2293 dbSNP
rs948597347 2293 dbSNP
rs956925561 2300 dbSNP
rs1029670537 2303 dbSNP
rs73947017 2308 dbSNP
rs964178992 2310 dbSNP
rs151209509 2311 dbSNP
rs1170073829 2320 dbSNP
rs1175041577 2343 dbSNP
rs1249140170 2347 dbSNP
rs1018421615 2351 dbSNP
rs1419025997 2357 dbSNP
rs1200147156 2358 dbSNP
rs1006205437 2359 dbSNP
rs745598999 2363 dbSNP
rs1164142075 2373 dbSNP
rs1401380116 2374 dbSNP
rs1047779835 2378 dbSNP
rs545004950 2379 dbSNP
rs1028592270 2382 dbSNP
rs897502761 2388 dbSNP
rs997395611 2401 dbSNP
rs1222732124 2406 dbSNP
rs1343542163 2406 dbSNP
rs1278602719 2412 dbSNP
rs1319561147 2414 dbSNP
rs1201946248 2437 dbSNP
rs965584874 2440 dbSNP
rs1019620901 2445 dbSNP
rs1009647423 2454 dbSNP
rs770733967 2456 dbSNP
rs1490000837 2460 dbSNP
rs144533747 2469 dbSNP
rs892460998 2473 dbSNP
rs1252838140 2475 dbSNP
rs1053741937 2477 dbSNP
rs528183086 2477 dbSNP
rs1168555944 2479 dbSNP
rs868442109 2480 dbSNP
rs560084411 2491 dbSNP
rs939120444 2493 dbSNP
rs1458522002 2494 dbSNP
rs567277950 2497 dbSNP
rs1305022012 2500 dbSNP
rs1363712846 2502 dbSNP
rs1404189391 2503 dbSNP
rs1298605580 2506 dbSNP
rs1000098913 2507 dbSNP
rs1044946992 2512 dbSNP
rs1294462569 2516 dbSNP
rs904413066 2519 dbSNP
rs946553389 2521 dbSNP
rs1321932221 2549 dbSNP
rs915124539 2559 dbSNP
rs988473374 2567 dbSNP
rs1044330146 2570 dbSNP
rs1490005778 2571 dbSNP
rs956726393 2572 dbSNP
rs1357746428 2581 dbSNP
rs1282329937 2583 dbSNP
rs1185122349 2587 dbSNP
rs542891991 2591 dbSNP
rs917090736 2592 dbSNP
rs1424612453 2595 dbSNP
rs922646136 2599 dbSNP
rs1383400583 2603 dbSNP
rs1159220396 2609 dbSNP
rs939785142 2609 dbSNP
rs976786664 2611 dbSNP
rs1229235312 2616 dbSNP
rs1359157902 2617 dbSNP
rs1346868302 2626 dbSNP
rs574181886 2636 dbSNP
rs1428450338 2637 dbSNP
rs964126287 2643 dbSNP
rs1278265645 2644 dbSNP
rs140480222 2644 dbSNP
rs1491047436 2645 dbSNP
rs1018327900 2646 dbSNP
rs367891294 2654 dbSNP
rs1440901300 2671 dbSNP
rs908191002 2681 dbSNP
rs984169563 2687 dbSNP
rs1309508296 2694 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions BCBL-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1015448. RNA binding protein: AGO2. Condition:BCBL-1 mRNA ...

- Haecker I; Gay LA; Yang Y; Hu J; Morse AM; et al., 2012, PLoS pathogens.

Article - Haecker I; Gay LA; Yang Y; Hu J; Morse AM; et al.
- PLoS pathogens, 2012
KSHV is the etiological agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and a subset of multicentricCastleman's disease (MCD). The fact that KSHV-encoded miRNAs are readily detectable in all KSHV-associated tumors suggests a potential role in viral pathogenesis and tumorigenesis. MiRNA-mediated regulation of gene expression is a complex network with each miRNA having many potential targets, and to date only few KSHV miRNA targets have been experimentally determined. A detailed understanding of KSHV miRNA functions requires high-through putribonomics to globally analyze putative miRNA targets in a cell type-specific manner. We performed Ago HITS-CLIP to identify viral and cellular miRNAs and their cognate targets in two latently KSHV-infected PEL cell lines. Ago HITS-CLIP recovered 1170 and 950 cellular KSHV miRNA targets from BCBL-1 and BC-3, respectively. Importantly, enriched clusters contained KSHV miRNA seed matches in the 3'UTRs of numerous well characterized targets, among them THBS1, BACH1, and C/EBPbeta. KSHV miRNA targets were strongly enriched for genes involved in multiple pathways central for KSHV biology, such as apoptosis, cell cycle regulation, lymphocyte proliferation, and immune evasion, thus further supporting a role in KSHV pathogenesis and potentially tumorigenesis. A limited number of viral transcripts were also enriched by HITS-CLIP including vIL-6 expressed only in a subset of PEL cells during latency. Interestingly, Ago HITS-CLIP revealed extremely high levels of Ago-associated KSHV miRNAs especially in BC-3 cells where more than 70% of all miRNAs are of viral origin. This suggests that in addition to seed match-specific targeting of cellular genes, KSHV miRNAs may also function by hijacking RISCs, thereby contributing to a global de-repression of cellular gene expression due to the loss of regulation by human miRNAs. In summary, we provide an extensive list of cellular and viral miRNA targets representing an important resource to decipher KSHV miRNA function.
LinkOut: [PMID: 22927820]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048188. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_ptb_knockdown ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1015448
Method / RBP HITS-CLIP / AGO2
Cell line / Condition BCBL-1 / BCBL-1 mRNA
Location of target site ENST00000334295.4 | 3UTR | AAACGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUUUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22927820 / GSE41357
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1048188
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_ptb_knockdown
Location of target site ENST00000334295.4 | 3UTR | AAACGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUUUUAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1013116
Method / RBP HITS-CLIP  / AGO
Cell line / Condition hMSC / hMSC-replicate-5
Location of target site ENST00000334295.4 | 3UTR | UGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUUUUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24038734 / GSE41272
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT085323 MORC3 MORC family CW-type zinc finger 3 2 2
MIRT089441 STAMBP STAM binding protein 2 2
MIRT089456 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT111856 CCND1 cyclin D1 2 2
MIRT184933 ZNF268 zinc finger protein 268 2 2
MIRT215288 CREBRF CREB3 regulatory factor 2 2
MIRT237300 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT238446 MYO10 myosin X 2 4
MIRT273827 RPL41 ribosomal protein L41 2 2
MIRT282703 HOOK1 hook microtubule tethering protein 1 2 2
MIRT347970 ZNF850 zinc finger protein 850 2 2
MIRT371076 KLF3 Kruppel like factor 3 2 2
MIRT464339 USP6NL USP6 N-terminal like 2 2
MIRT470034 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT477506 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT482886 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 2 2
MIRT492606 POLR3E RNA polymerase III subunit E 2 2
MIRT502294 GNG12 G protein subunit gamma 12 2 6
MIRT507600 DCTN4 dynactin subunit 4 2 4
MIRT510728 SON SON DNA binding protein 2 6
MIRT514065 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 8
MIRT519718 ZNF512B zinc finger protein 512B 2 4
MIRT520890 STRN striatin 2 2
MIRT521760 PPIL1 peptidylprolyl isomerase like 1 2 6
MIRT526874 ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit 2 2
MIRT530232 WSB2 WD repeat and SOCS box containing 2 2 2
MIRT532003 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT533371 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 4
MIRT547106 PIGW phosphatidylinositol glycan anchor biosynthesis class W 2 2
MIRT548189 FOXA1 forkhead box A1 2 2
MIRT552935 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT560085 ZNF195 zinc finger protein 195 2 2
MIRT561726 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT562713 ZNF415 zinc finger protein 415 2 2
MIRT562761 ZNF846 zinc finger protein 846 2 2
MIRT564159 ZNF117 zinc finger protein 117 2 2
MIRT565673 SETD5 SET domain containing 5 2 2
MIRT565718 SESN3 sestrin 3 2 2
MIRT566026 RFX1 regulatory factor X1 2 2
MIRT569048 ZNF655 zinc finger protein 655 2 2
MIRT570367 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT570410 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT570443 TMEM189 transmembrane protein 189 2 2
MIRT571738 RNF11 ring finger protein 11 2 2
MIRT575042 Tpgs2 tubulin polyglutamylase complex subunit 2 2 4
MIRT614330 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT617629 RAB3IP RAB3A interacting protein 2 2
MIRT621667 UBE4B ubiquitination factor E4B 2 2
MIRT639906 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT651436 XRCC5 X-ray repair cross complementing 5 2 2
MIRT683853 ZNF208 zinc finger protein 208 2 2
MIRT684841 TPGS2 tubulin polyglutamylase complex subunit 2 2 5
MIRT689347 ZNF83 zinc finger protein 83 2 2
MIRT692492 SPIN4 spindlin family member 4 2 2
MIRT695711 OLA1 Obg like ATPase 1 2 2
MIRT698219 TMEM248 transmembrane protein 248 2 2
MIRT711560 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT712867 TMEM67 transmembrane protein 67 2 2
MIRT722956 TSPAN1 tetraspanin 1 2 2
MIRT723622 SOBP sine oculis binding protein homolog 2 2
MIRT724176 ABCF2 ATP binding cassette subfamily F member 2 2 2
MIRT755363 LMBR1 limb development membrane protein 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-758 Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-758 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-758 5-Fluorouracil approved 3385 Quantitative real-time PCR human squamous cell carcinoma cell line KYSE410 21743970 2011 up-regulated
miR-758 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-758 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-758-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-758-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-758-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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