miRTarBase - #MIRT684875


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pre-miRNA Information
pre-miRNA hsa-mir-378f   
Genomic Coordinates chr1: 23929070 - 23929147
Description Homo sapiens miR-378f stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-378f
Sequence 52| ACUGGACUUGGAGCCAGAAG |71
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 18 1 + 23929138 29233923 MiREDiBase
A-to-I 19 1 + 23929139 29233923 MiREDiBase
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol P4HB   
Synonyms CLCRP1, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB
Description prolyl 4-hydroxylase subunit beta
Transcript NM_000918   
Expression
Putative miRNA Targets on P4HB
3'UTR of P4HB
(miRNA target sites are highlighted)		 
>P4HB|NM_000918|3'UTR
   1 TACGCAAAGCCAGACCCGGGCGCTGCCGAGACCCCTCGGGGGCTGCACACCCAGCAGCAGCGCACGCCTCCGAAGCCTGC
  81 GGCCTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTCTCTGAAGTGACACCTCACCCCTACACACCGTCCGTT
 161 CACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGATCCATCTCCAGGCAGCCCACCCTGGTGGGGCTTGTTT
 241 CCTGAAACCATGATGTACTTTTTCATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGAGTCTCGCTGCCTCCCT
 321 CCCGCGGGAGGTTTCTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGACATCAGGGTATTTGTTCC
 401 ACCTTGGCCAGGCCTCCTCGGAGAAGCTTGTCCCCCGTGTGGGAGGGACGGAGCCGGACTGGACATGGTCACTCAGTACC
 481 GCCTGCAGTGTCGCCATGACTGATCATGGCTCTTGCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCC
 561 CCATGCCTGGAAGAGGAGCTGGTGGCTGCCAGCCCTGGGGCCCGGCACAGGCCTGGGCCTTCCCCTTCCCTCAAGCCAGG
 641 GCTCCTCCTCCTGTCGTGGGCTCATTGTGACCACTGGCCTCTCTACAGCACGGCCTGTGGCCTGTTCAAGGCAGAACCAC
 721 GACCCTTGACTCCCGGGTGGGGAGGTGGCCAAGGATGCTGGAGCTGAATCAGACGCTGACAGTTCTTCAGGCATTTCTAT
 801 TTCACAATCGAATTGAACACATTGGCCAAATAAAGTTGAAATTTTACCACCTGTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaagaccgagguuCAGGUCa 5'
                       |||||| 
Target 5' catacatgagtctGTCCAGa 3'
 264 - 283 120.00 -9.20
2 
miRNA  3' gaagacCGAGGUUCAGGUCa 5'
                |:|| :||||: | 
Target 5' taccgtGTTCGGAGTCTCGc 3'
 292 - 311 106.00 -11.40
3 
miRNA  3' gaaGACCGAGGUUCAGGUCa 5'
             ||  | :|||| |||| 
Target 5' cccCTTCCCTCAAG-CCAGg 3'
 622 - 640 105.00 -11.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1178163 217 ClinVar
COSN30495905 3 COSMIC
COSN26987752 15 COSMIC
COSN30516087 22 COSMIC
COSN30535817 25 COSMIC
COSN30602976 37 COSMIC
COSN30663388 38 COSMIC
COSN30695926 62 COSMIC
COSN31518822 66 COSMIC
COSN30469185 71 COSMIC
COSN31541047 80 COSMIC
COSN30507184 81 COSMIC
COSN30156024 86 COSMIC
COSN13754763 100 COSMIC
COSN28769471 106 COSMIC
COSN30495126 122 COSMIC
COSN30450497 152 COSMIC
COSN30469596 153 COSMIC
COSN30135828 187 COSMIC
COSN31975531 434 COSMIC
COSN16996921 449 COSMIC
COSN5421226 707 COSMIC
COSN29379840 743 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs758887971 1 dbSNP
rs370688004 3 dbSNP
rs186188916 4 dbSNP
rs758893845 5 dbSNP
rs200808646 6 dbSNP
rs1318161078 8 dbSNP
rs199996586 14 dbSNP
rs1380154793 15 dbSNP
rs201550009 16 dbSNP
rs200613922 17 dbSNP
rs774068400 18 dbSNP
rs980530243 18 dbSNP
rs199842092 21 dbSNP
rs761747641 22 dbSNP
rs1439767863 24 dbSNP
rs1159994262 25 dbSNP
rs774085259 26 dbSNP
rs201806182 27 dbSNP
rs542316751 28 dbSNP
rs779818882 32 dbSNP
rs200662613 33 dbSNP
rs769528841 34 dbSNP
rs745389097 37 dbSNP
rs199734113 38 dbSNP
rs1182183148 39 dbSNP
rs960283696 42 dbSNP
rs1240889367 44 dbSNP
rs1311567138 45 dbSNP
rs770582948 47 dbSNP
rs753242374 48 dbSNP
rs1457866660 49 dbSNP
rs779201521 51 dbSNP
rs1244365701 52 dbSNP
rs201612293 53 dbSNP
rs911494615 56 dbSNP
rs147064630 61 dbSNP
rs754037583 62 dbSNP
rs199642683 64 dbSNP
rs201329193 65 dbSNP
rs1179925995 66 dbSNP
rs200355357 70 dbSNP
rs202111707 71 dbSNP
rs201042887 72 dbSNP
rs200423004 76 dbSNP
rs1344196961 80 dbSNP
rs1400863373 81 dbSNP
rs202217417 83 dbSNP
rs201016924 85 dbSNP
rs1000637508 86 dbSNP
rs1395566157 87 dbSNP
rs1313703640 90 dbSNP
rs1323792378 97 dbSNP
rs1277756743 101 dbSNP
rs200134721 103 dbSNP
rs1020656115 104 dbSNP
rs201677863 105 dbSNP
rs901601284 106 dbSNP
rs919582693 107 dbSNP
rs1045145910 123 dbSNP
rs947789527 128 dbSNP
rs1396019738 130 dbSNP
rs1039084207 137 dbSNP
rs200828785 145 dbSNP
rs200054528 147 dbSNP
rs1257759894 148 dbSNP
rs201910369 153 dbSNP
rs1467037320 154 dbSNP
rs200750945 156 dbSNP
rs1470642824 157 dbSNP
rs199961374 158 dbSNP
rs201824642 166 dbSNP
rs1048663029 167 dbSNP
rs200713670 168 dbSNP
rs536396561 170 dbSNP
rs199793402 171 dbSNP
rs1277857756 172 dbSNP
rs1243688395 175 dbSNP
rs1220917320 176 dbSNP
rs1277100213 179 dbSNP
rs561138949 187 dbSNP
rs1257280486 188 dbSNP
rs924795868 190 dbSNP
rs201237023 203 dbSNP
rs1487077703 205 dbSNP
rs977656159 208 dbSNP
rs897361947 212 dbSNP
rs968972501 215 dbSNP
rs2277706 217 dbSNP
rs199734473 218 dbSNP
rs767981895 222 dbSNP
rs1202274838 224 dbSNP
rs201581381 227 dbSNP
rs867755982 229 dbSNP
rs550784125 232 dbSNP
rs918021928 234 dbSNP
rs200334750 248 dbSNP
rs201948230 250 dbSNP
rs1216968683 252 dbSNP
rs938050931 255 dbSNP
rs571536625 268 dbSNP
rs201121769 269 dbSNP
rs774057600 270 dbSNP
rs925190764 271 dbSNP
rs979353786 271 dbSNP
rs966608675 272 dbSNP
rs1020702188 279 dbSNP
rs886926360 280 dbSNP
rs200284911 282 dbSNP
rs995356961 287 dbSNP
rs975903645 291 dbSNP
rs546917582 293 dbSNP
rs201874292 294 dbSNP
rs151253783 295 dbSNP
rs199988706 296 dbSNP
rs1017384351 297 dbSNP
rs1007619982 298 dbSNP
rs887490895 301 dbSNP
rs1044699497 302 dbSNP
rs947701820 308 dbSNP
rs202216013 309 dbSNP
rs201258965 310 dbSNP
rs1349643106 316 dbSNP
rs1056597907 317 dbSNP
rs1336672668 323 dbSNP
rs200164217 324 dbSNP
rs181783040 325 dbSNP
rs949559793 326 dbSNP
rs977605276 332 dbSNP
rs1355359042 337 dbSNP
rs1226235061 346 dbSNP
rs1288750592 349 dbSNP
rs560510378 353 dbSNP
rs1322098451 354 dbSNP
rs896543575 355 dbSNP
rs200571378 356 dbSNP
rs1457263939 364 dbSNP
rs1224852728 366 dbSNP
rs199972106 373 dbSNP
rs201922333 380 dbSNP
rs11558887 381 dbSNP
rs1381242848 389 dbSNP
rs530240512 390 dbSNP
rs1804510 396 dbSNP
rs1406311479 399 dbSNP
rs780393047 403 dbSNP
rs1481004256 408 dbSNP
rs1446739522 409 dbSNP
rs199628220 414 dbSNP
rs562857463 415 dbSNP
rs201513679 417 dbSNP
rs1025410599 419 dbSNP
rs995315684 420 dbSNP
rs1255950727 427 dbSNP
rs573023532 427 dbSNP
rs1461692784 436 dbSNP
rs200774373 437 dbSNP
rs369044530 441 dbSNP
rs199766901 445 dbSNP
rs201028813 449 dbSNP
rs200278911 450 dbSNP
rs1256153869 452 dbSNP
rs201860755 453 dbSNP
rs951895824 454 dbSNP
rs577027305 455 dbSNP
rs1182979652 456 dbSNP
rs558786948 457 dbSNP
rs1027284589 467 dbSNP
rs1012206951 470 dbSNP
rs993176090 474 dbSNP
rs1284981507 479 dbSNP
rs896133007 480 dbSNP
rs1434528993 481 dbSNP
rs201256987 482 dbSNP
rs200328297 483 dbSNP
rs1056141193 485 dbSNP
rs1412210217 486 dbSNP
rs540567085 488 dbSNP
rs201943438 492 dbSNP
rs201169340 493 dbSNP
rs1252080570 494 dbSNP
rs200429607 500 dbSNP
rs1329593636 502 dbSNP
rs202137950 505 dbSNP
rs200909487 506 dbSNP
rs757287145 508 dbSNP
rs1411783056 511 dbSNP
rs199952117 513 dbSNP
rs1280006439 515 dbSNP
rs1480111284 516 dbSNP
rs1014167105 525 dbSNP
rs1198736659 538 dbSNP
rs1265605892 539 dbSNP
rs11558890 540 dbSNP
rs1278045857 541 dbSNP
rs201829447 541 dbSNP
rs201105668 544 dbSNP
rs200178858 545 dbSNP
rs1477690937 551 dbSNP
rs1445237140 553 dbSNP
rs1379581379 559 dbSNP
rs1375214170 563 dbSNP
rs201628613 566 dbSNP
rs912517739 570 dbSNP
rs200785188 572 dbSNP
rs1176906414 576 dbSNP
rs1171430664 579 dbSNP
rs1402265584 581 dbSNP
rs1002252416 588 dbSNP
rs199777206 594 dbSNP
rs201618550 595 dbSNP
rs903957047 596 dbSNP
rs8324 600 dbSNP
rs199682639 603 dbSNP
rs1198353228 604 dbSNP
rs3210096 606 dbSNP
rs201508643 607 dbSNP
rs1345801288 608 dbSNP
rs1236663761 609 dbSNP
rs1063472 617 dbSNP
rs1284075177 624 dbSNP
rs556800261 625 dbSNP
rs1217748384 626 dbSNP
rs752575002 626 dbSNP
rs1223642792 630 dbSNP
rs11558889 638 dbSNP
rs190537631 640 dbSNP
rs571475357 644 dbSNP
rs1284436921 653 dbSNP
rs546905510 655 dbSNP
rs960659683 656 dbSNP
rs1416646781 658 dbSNP
rs1035074542 661 dbSNP
rs1419964409 663 dbSNP
rs1185316309 664 dbSNP
rs149227300 666 dbSNP
rs951800688 672 dbSNP
rs902208759 674 dbSNP
rs1443108571 675 dbSNP
rs920370851 681 dbSNP
rs1353190893 682 dbSNP
rs1241114962 685 dbSNP
rs1262755144 685 dbSNP
rs374510839 691 dbSNP
rs1209682553 692 dbSNP
rs1268601925 704 dbSNP
rs566730591 707 dbSNP
rs961745785 709 dbSNP
rs1015844869 720 dbSNP
rs1013801190 721 dbSNP
rs961249040 723 dbSNP
rs1010698351 728 dbSNP
rs1425040348 733 dbSNP
rs893284431 734 dbSNP
rs201310822 735 dbSNP
rs942904274 737 dbSNP
rs1408879380 739 dbSNP
rs548528911 742 dbSNP
rs1376208508 749 dbSNP
rs200432203 750 dbSNP
rs1190676785 752 dbSNP
rs1477184415 759 dbSNP
rs1392101227 769 dbSNP
rs202131032 774 dbSNP
rs1271285576 777 dbSNP
rs201211019 780 dbSNP
rs912828787 781 dbSNP
rs1050597 785 dbSNP
rs1043815948 788 dbSNP
rs1063495 797 dbSNP
rs1218490835 799 dbSNP
rs1197279498 808 dbSNP
rs562954955 809 dbSNP
rs1258025988 810 dbSNP
rs1284427644 813 dbSNP
rs200425539 814 dbSNP
rs1457820752 816 dbSNP
rs1051319651 822 dbSNP
rs1253558734 824 dbSNP
rs1422911430 836 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048188. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_ptb_knockdown ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaagaccgagguuCAGGUCa 5'
                       |||||| 
Target 5' cauacaugagucuGUCCAGa 3'
 		3 - 22
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048188
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_ptb_knockdown
Location of target site ENST00000331483.4 | 3UTR | UUCAUACAUGAGUCUGUCCAGAGUGCUUGCUACCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
27 hsa-miR-378f Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT463100 ZNF609 zinc finger protein 609 2 2
MIRT469371 REST RE1 silencing transcription factor 2 6
MIRT495441 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT513606 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT520414 TXNL1 thioredoxin like 1 2 4
MIRT525111 PRKD2 protein kinase D2 2 2
MIRT525979 SPA17 sperm autoantigenic protein 17 2 2
MIRT527002 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT529215 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT529835 ARGFX arginine-fifty homeobox 2 2
MIRT532300 HAUS3 HAUS augmin like complex subunit 3 2 2
MIRT537577 ESYT2 extended synaptotagmin 2 2 2
MIRT543140 AKT1 AKT serine/threonine kinase 1 2 2
MIRT554924 RAP1B RAP1B, member of RAS oncogene family 2 2
MIRT564970 WTAP WT1 associated protein 2 2
MIRT570115 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT652734 TGFB2 transforming growth factor beta 2 2 2
MIRT655948 NDST1 N-deacetylase and N-sulfotransferase 1 2 2
MIRT655997 MYRF myelin regulatory factor 2 2
MIRT684875 P4HB prolyl 4-hydroxylase subunit beta 2 2
MIRT692969 LGSN lengsin, lens protein with glutamine synthetase domain 2 2
MIRT693737 ACACA acetyl-CoA carboxylase alpha 2 2
MIRT710991 PPARGC1B PPARG coactivator 1 beta 2 2
MIRT712247 RCC2 regulator of chromosome condensation 2 2 2
MIRT718602 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT723499 WDR33 WD repeat domain 33 2 2
MIRT725448 HIPK3 homeodomain interacting protein kinase 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-miR-378f Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (SW480, HCT-116)
hsa-miR-378f Erlotinib 176870 NSC718781 approved resistant High Head And Neck Squamous Cell Carcinoma cell line (HN6)
hsa-mir-378f Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-378f Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-378f Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-378f Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)

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