pre-miRNA Information
pre-miRNA hsa-mir-124-1   
Genomic Coordinates chr8: 9903388 - 9903472
Description Homo sapiens miR-124-1 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-2   
Genomic Coordinates chr8: 64379149 - 64379257
Description Homo sapiens miR-124-2 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-3   
Genomic Coordinates chr20: 63178500 - 63178586
Description Homo sapiens miR-124-3 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-124-5p
Sequence 14| CGUGUUCACAGCGGACCUUGAU |35
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 8 8 + 64379180 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1280076135 1 dbSNP
rs775858016 4 dbSNP
rs760972715 7 dbSNP
rs1334649236 11 dbSNP
rs1160219511 12 dbSNP
rs764591061 12 dbSNP
rs1261326747 13 dbSNP
rs1344491363 20 dbSNP
rs1340798465 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Increase Plasma Polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Peripheral blood mononuclear cell Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol POTED   
Synonyms A26B3, ANKRD21, CT104.1, POTE, POTE-21, POTE21
Description POTE ankyrin domain family member D
Transcript NM_174981   
Expression
Putative miRNA Targets on POTED
3'UTR of POTED
(miRNA target sites are highlighted)
>POTED|NM_174981|3'UTR
   1 GTACAGTGGACAGCTTAGG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uaguuccaggcGACACUUGUgc 5'
                     | |||:|||  
Target 5' --------gtaCAGTGGACAgc 3'
1 - 14 111.00 -8.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31961891 9 COSMIC
COSN5028327 20 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1276157386 6 dbSNP
rs768070926 30 dbSNP
rs1296859362 36 dbSNP
rs776163294 38 dbSNP
rs1257431422 43 dbSNP
rs761656523 44 dbSNP
rs1160839455 50 dbSNP
rs1348516768 52 dbSNP
rs765204623 53 dbSNP
rs1384921280 57 dbSNP
rs201280833 59 dbSNP
rs1188473127 64 dbSNP
rs562566026 70 dbSNP
rs1444251120 83 dbSNP
rs1259775024 86 dbSNP
rs1204596512 99 dbSNP
rs1253985332 101 dbSNP
rs1287998387 102 dbSNP
rs531439387 107 dbSNP
rs1358455307 124 dbSNP
rs949601332 127 dbSNP
rs551550729 134 dbSNP
rs1246504868 163 dbSNP
rs1046652159 173 dbSNP
rs1317025735 188 dbSNP
rs1400018276 193 dbSNP
rs1309534072 209 dbSNP
rs1361805969 223 dbSNP
rs1300583192 235 dbSNP
rs1382358145 244 dbSNP
rs1454503773 271 dbSNP
rs1164152749 328 dbSNP
rs1473917905 336 dbSNP
rs1371479676 355 dbSNP
rs902653376 386 dbSNP
rs1162673308 387 dbSNP
rs1054400389 390 dbSNP
rs999679440 390 dbSNP
rs10222155 391 dbSNP
rs1490139468 410 dbSNP
rs1290357255 411 dbSNP
rs1211371276 412 dbSNP
rs1337055421 416 dbSNP
rs2849161 420 dbSNP
rs1269214726 436 dbSNP
rs368712337 457 dbSNP
rs2150359 506 dbSNP
rs1218780873 545 dbSNP
rs1341801209 564 dbSNP
rs1280700450 582 dbSNP
rs1403657757 608 dbSNP
rs1242841111 618 dbSNP
rs1349766853 630 dbSNP
rs893546574 640 dbSNP
rs1407378883 641 dbSNP
rs1007058464 648 dbSNP
rs1017913935 668 dbSNP
rs1388744034 675 dbSNP
rs1466246669 684 dbSNP
rs1425845488 710 dbSNP
rs1197305938 714 dbSNP
rs1407014733 725 dbSNP
rs1200806440 726 dbSNP
rs965058467 726 dbSNP
rs1435860863 731 dbSNP
rs1324174802 732 dbSNP
rs1375851641 736 dbSNP
rs1444250033 740 dbSNP
rs1222300474 758 dbSNP
rs772964507 761 dbSNP
rs998073102 763 dbSNP
rs1377100233 764 dbSNP
rs2334592 783 dbSNP
rs1439135868 785 dbSNP
rs1243628689 794 dbSNP
rs1334321449 797 dbSNP
rs4524196 835 dbSNP
rs8129783 858 dbSNP
rs4416309 860 dbSNP
rs1263161653 862 dbSNP
rs1402678495 864 dbSNP
rs1174376379 872 dbSNP
rs1413963989 878 dbSNP
rs1425868306 896 dbSNP
rs1174216026 904 dbSNP
rs1357895101 920 dbSNP
rs1212128432 931 dbSNP
rs1178975285 935 dbSNP
rs1458814884 936 dbSNP
rs1274298360 951 dbSNP
rs1202555058 952 dbSNP
rs1312264954 959 dbSNP
rs2183548 963 dbSNP
rs1457733388 967 dbSNP
rs1221416936 969 dbSNP
rs1177086239 970 dbSNP
rs1240424558 972 dbSNP
rs571254196 973 dbSNP
rs4490281 974 dbSNP
rs1379468310 978 dbSNP
rs1334962451 990 dbSNP
rs2150360 993 dbSNP
rs1473847384 999 dbSNP
rs1336192712 1028 dbSNP
rs1398911814 1040 dbSNP
rs1379534804 1074 dbSNP
rs1159034077 1090 dbSNP
rs141924343 1100 dbSNP
rs775908656 1114 dbSNP
rs879112925 1154 dbSNP
rs112360650 1158 dbSNP
rs1441304972 1170 dbSNP
rs1383074444 1172 dbSNP
rs2104806 1173 dbSNP
rs951399480 1181 dbSNP
rs983968509 1212 dbSNP
rs1333050297 1213 dbSNP
rs1017215658 1217 dbSNP
rs1487597321 1224 dbSNP
rs963461458 1237 dbSNP
rs1310198424 1245 dbSNP
rs990869065 1251 dbSNP
rs1341915934 1253 dbSNP
rs1356257564 1274 dbSNP
rs1313252075 1284 dbSNP
rs1244828107 1292 dbSNP
rs916558602 1332 dbSNP
rs949402531 1346 dbSNP
rs1428648704 1352 dbSNP
rs1359883707 1418 dbSNP
rs1298733569 1488 dbSNP
rs1421334281 1529 dbSNP
rs982108833 1564 dbSNP
rs1197363388 1574 dbSNP
rs1424064698 1577 dbSNP
rs1415429729 1578 dbSNP
rs1184272695 1598 dbSNP
rs1260396498 1607 dbSNP
rs796573791 1636 dbSNP
rs182956641 1655 dbSNP
rs201172569 1665 dbSNP
rs1481189971 1673 dbSNP
rs1217960248 1700 dbSNP
rs4471970 1703 dbSNP
rs1489527835 1716 dbSNP
rs1264082507 1721 dbSNP
rs1200071645 1725 dbSNP
rs935614341 1726 dbSNP
rs4555432 1734 dbSNP
rs202036840 1749 dbSNP
rs1292271108 1757 dbSNP
rs1212953767 1784 dbSNP
rs533807683 1795 dbSNP
rs760953377 1799 dbSNP
rs187301606 1801 dbSNP
rs200346536 1802 dbSNP
rs1401796928 1810 dbSNP
rs4239828 1835 dbSNP
rs4239829 1840 dbSNP
rs1423025103 1845 dbSNP
rs1476793180 1850 dbSNP
rs1351319053 1865 dbSNP
rs1172780521 1877 dbSNP
rs1464692979 1878 dbSNP
rs1373408393 1901 dbSNP
rs1423745426 1917 dbSNP
rs1195160057 1958 dbSNP
rs371500066 1961 dbSNP
rs1479089744 1965 dbSNP
rs1465315715 1966 dbSNP
rs1191034911 2000 dbSNP
rs1489006991 2028 dbSNP
rs8131141 2034 dbSNP
rs1300894860 2035 dbSNP
rs1403813877 2061 dbSNP
rs1196964279 2066 dbSNP
rs1415030391 2071 dbSNP
rs1258835261 2077 dbSNP
rs1220477818 2080 dbSNP
rs1310383805 2096 dbSNP
rs1300487694 2097 dbSNP
rs1297022601 2101 dbSNP
rs1369436455 2110 dbSNP
rs1337856446 2119 dbSNP
rs548047664 2123 dbSNP
rs1053922808 2127 dbSNP
rs142359277 2132 dbSNP
rs1172206780 2148 dbSNP
rs1308624578 2160 dbSNP
rs1376498040 2167 dbSNP
rs1175941710 2168 dbSNP
rs1434172698 2169 dbSNP
rs367816011 2178 dbSNP
rs567887040 2180 dbSNP
rs1269945186 2184 dbSNP
rs753979750 2197 dbSNP
rs893967934 2198 dbSNP
rs1457489301 2245 dbSNP
rs1238962120 2246 dbSNP
rs1200667404 2250 dbSNP
rs1482315467 2265 dbSNP
rs1255391039 2287 dbSNP
rs1233907668 2292 dbSNP
rs1313840735 2321 dbSNP
rs202146573 2324 dbSNP
rs1306811106 2325 dbSNP
rs1239083750 2337 dbSNP
rs1377253625 2338 dbSNP
rs1332942287 2348 dbSNP
rs1449879245 2350 dbSNP
rs1400847424 2385 dbSNP
rs1302872765 2391 dbSNP
rs1467032935 2399 dbSNP
rs1379814469 2419 dbSNP
rs1157246582 2426 dbSNP
rs1232941184 2435 dbSNP
rs1254634748 2447 dbSNP
rs1484326727 2455 dbSNP
rs887077189 2457 dbSNP
rs3017190 2467 dbSNP
rs1381224885 2473 dbSNP
rs1180712087 2482 dbSNP
rs1440858806 2493 dbSNP
rs1211939268 2500 dbSNP
rs112139263 2507 dbSNP
rs4046835 2508 dbSNP
rs1201040408 2509 dbSNP
rs1484200600 2514 dbSNP
rs1283778396 2534 dbSNP
rs1215706356 2535 dbSNP
rs73148745 2543 dbSNP
rs1311066646 2544 dbSNP
rs4046837 2582 dbSNP
rs1242193914 2585 dbSNP
rs1339472434 2586 dbSNP
rs1312818415 2603 dbSNP
rs545456990 2613 dbSNP
rs3017191 2621 dbSNP
rs1262525751 2633 dbSNP
rs1377859606 2642 dbSNP
rs1487377364 2643 dbSNP
rs1419524380 2662 dbSNP
rs1361596178 2663 dbSNP
rs3017192 2664 dbSNP
rs1195960445 2666 dbSNP
rs1262291709 2680 dbSNP
rs373410283 2681 dbSNP
rs1471934659 2705 dbSNP
rs191745103 2729 dbSNP
rs1368056246 2741 dbSNP
rs1188399378 2750 dbSNP
rs1432526699 2754 dbSNP
rs1192821993 2756 dbSNP
rs1488550298 2760 dbSNP
rs1287940263 2764 dbSNP
rs4046840 2785 dbSNP
rs1488114905 2793 dbSNP
rs1207779058 2797 dbSNP
rs1355229489 2808 dbSNP
rs1265651703 2842 dbSNP
rs1246437545 2847 dbSNP
rs1194152319 2854 dbSNP
rs2334594 2873 dbSNP
rs536821056 2874 dbSNP
rs2334595 2881 dbSNP
rs1399965081 2893 dbSNP
rs4046841 2897 dbSNP
rs1379207127 2915 dbSNP
rs1320707721 2929 dbSNP
rs1403937533 2931 dbSNP
rs1390370111 2939 dbSNP
rs556490059 2941 dbSNP
rs1164016252 2942 dbSNP
rs1463120790 2943 dbSNP
rs2334596 2944 dbSNP
rs1421608201 2949 dbSNP
rs1192993663 2950 dbSNP
rs1478111965 2954 dbSNP
rs1265177740 2962 dbSNP
rs2334597 2965 dbSNP
rs2334598 2967 dbSNP
rs757229848 2968 dbSNP
rs765781265 2969 dbSNP
rs1267665339 2992 dbSNP
rs1211243440 2993 dbSNP
rs576434152 2998 dbSNP
rs538743581 3003 dbSNP
rs1256872693 3020 dbSNP
rs1157722765 3032 dbSNP
rs183958834 3038 dbSNP
rs1358054851 3043 dbSNP
rs1464660555 3060 dbSNP
rs2334599 3082 dbSNP
rs4046842 3083 dbSNP
rs2334600 3086 dbSNP
rs1288978119 3121 dbSNP
rs879006654 3141 dbSNP
rs78806737 3145 dbSNP
rs1814006 3151 dbSNP
rs1443424049 3158 dbSNP
rs1299626984 3159 dbSNP
rs1814007 3164 dbSNP
rs2334601 3167 dbSNP
rs2334602 3168 dbSNP
rs758820384 3192 dbSNP
rs1466199480 3193 dbSNP
rs1421647904 3200 dbSNP
rs1277959134 3203 dbSNP
rs1477604202 3222 dbSNP
rs1378013573 3227 dbSNP
rs1200648734 3228 dbSNP
rs1402108262 3231 dbSNP
rs4046830 3234 dbSNP
rs1482369890 3239 dbSNP
rs1456180007 3240 dbSNP
rs1200136939 3241 dbSNP
rs141566892 3242 dbSNP
rs1262513931 3259 dbSNP
rs1430440668 3267 dbSNP
rs942402576 3269 dbSNP
rs113348606 3270 dbSNP
rs1455109194 3272 dbSNP
rs3080117 3276 dbSNP
rs1275818835 3278 dbSNP
rs1236883070 3279 dbSNP
rs1375035740 3279 dbSNP
rs1175869468 3281 dbSNP
rs28888521 3297 dbSNP
rs1447663913 3304 dbSNP
rs4098544 3312 dbSNP
rs1332223160 3319 dbSNP
rs900951037 3323 dbSNP
rs1425711532 3336 dbSNP
rs1175345229 3339 dbSNP
rs997834029 3345 dbSNP
rs1379340577 3350 dbSNP
rs28782309 3352 dbSNP
rs1178838435 3358 dbSNP
rs1470930238 3365 dbSNP
rs1235272287 3386 dbSNP
rs1208740319 3387 dbSNP
rs1442366346 3389 dbSNP
rs1378058438 3393 dbSNP
rs1421145415 3411 dbSNP
rs1159125203 3414 dbSNP
rs1348855172 3417 dbSNP
rs1351924348 3421 dbSNP
rs1308866648 3424 dbSNP
rs1241180464 3426 dbSNP
rs1375753032 3429 dbSNP
rs879066571 3434 dbSNP
rs879040057 3436 dbSNP
rs4098543 3439 dbSNP
rs1447368792 3448 dbSNP
rs1359739503 3457 dbSNP
rs8129761 3459 dbSNP
rs572090218 3461 dbSNP
rs1457839329 3462 dbSNP
rs1417682303 3465 dbSNP
rs8131497 3466 dbSNP
rs1158980709 3475 dbSNP
rs1402092768 3476 dbSNP
rs1373855839 3477 dbSNP
rs1180838160 3478 dbSNP
rs1258876828 3481 dbSNP
rs1472840317 3481 dbSNP
rs554002512 3482 dbSNP
rs573864437 3487 dbSNP
rs1308993732 3489 dbSNP
rs1487567689 3490 dbSNP
rs1025771550 3502 dbSNP
rs1285793171 3505 dbSNP
rs3017193 3514 dbSNP
rs542762558 3519 dbSNP
rs1217729342 3524 dbSNP
rs1319012138 3526 dbSNP
rs1374871135 3537 dbSNP
rs149752065 3538 dbSNP
rs8131522 3540 dbSNP
rs2878225 3541 dbSNP
rs1285034300 3546 dbSNP
rs1398101897 3548 dbSNP
rs545110258 3549 dbSNP
rs1298600759 3551 dbSNP
rs1219257984 3560 dbSNP
rs1267096614 3561 dbSNP
rs1347831661 3565 dbSNP
rs1468887206 3566 dbSNP
rs1405495825 3567 dbSNP
rs3080118 3575 dbSNP
rs755846239 3575 dbSNP
rs1419418348 3585 dbSNP
rs565000593 3589 dbSNP
rs1477131776 3592 dbSNP
rs527252161 3594 dbSNP
rs1236150726 3615 dbSNP
rs1441144654 3617 dbSNP
rs887023714 3618 dbSNP
rs1005889921 3619 dbSNP
rs1221134414 3621 dbSNP
rs1335667124 3629 dbSNP
rs1177493948 3634 dbSNP
rs1216817299 3638 dbSNP
rs1317286694 3639 dbSNP
rs1278763656 3640 dbSNP
rs1383751923 3644 dbSNP
rs754658600 3648 dbSNP
rs1292683181 3651 dbSNP
rs4046831 3655 dbSNP
rs113198593 3660 dbSNP
rs1164983571 3663 dbSNP
rs1016730287 3678 dbSNP
rs1421491631 3683 dbSNP
rs1166332311 3687 dbSNP
rs547092366 3692 dbSNP
rs1464644203 3696 dbSNP
rs567907733 3701 dbSNP
rs1397240266 3703 dbSNP
rs1171707513 3705 dbSNP
rs1430758814 3710 dbSNP
rs1423540851 3712 dbSNP
rs1190905310 3719 dbSNP
rs8130064 3720 dbSNP
rs1462438294 3721 dbSNP
rs1331079709 3725 dbSNP
rs2334603 3726 dbSNP
rs2334604 3734 dbSNP
rs2334605 3739 dbSNP
rs1444592744 3741 dbSNP
rs958806222 3742 dbSNP
rs1280404991 3745 dbSNP
rs1234681282 3748 dbSNP
rs550225230 3748 dbSNP
rs1372807122 3752 dbSNP
rs2334606 3759 dbSNP
rs1378753917 3761 dbSNP
rs1226643873 3763 dbSNP
rs1295210452 3768 dbSNP
rs1445463295 3771 dbSNP
rs1335334346 3772 dbSNP
rs1218001081 3785 dbSNP
rs550497058 3787 dbSNP
rs1357871452 3793 dbSNP
rs1175868825 3802 dbSNP
rs1454981326 3804 dbSNP
rs1023663831 3810 dbSNP
rs2334607 3816 dbSNP
rs1204751501 3820 dbSNP
rs1399081523 3824 dbSNP
rs372760414 3826 dbSNP
rs1482073827 3827 dbSNP
rs1255334771 3835 dbSNP
rs982068009 3839 dbSNP
rs868756316 3842 dbSNP
rs1306745960 3849 dbSNP
rs1475815759 3851 dbSNP
rs1335908008 3854 dbSNP
rs2334608 3858 dbSNP
rs4263202 3868 dbSNP
rs1170643603 3869 dbSNP
rs2334609 3870 dbSNP
rs569903787 3879 dbSNP
rs372059940 3886 dbSNP
rs1330008685 3889 dbSNP
rs4046832 3892 dbSNP
rs1358736745 3906 dbSNP
rs8130373 3919 dbSNP
rs1314822254 3922 dbSNP
rs1419337098 3926 dbSNP
rs1356252454 3930 dbSNP
rs1364543021 3938 dbSNP
rs1184149936 3944 dbSNP
rs9967975 3945 dbSNP
rs4046833 3953 dbSNP
rs1422098843 3957 dbSNP
rs1255445071 3958 dbSNP
rs538878542 3969 dbSNP
rs1486588419 3973 dbSNP
rs1276284137 3975 dbSNP
rs4046834 3976 dbSNP
rs1214871650 3982 dbSNP
rs558603959 3983 dbSNP
rs1242035232 3987 dbSNP
rs1310060260 3988 dbSNP
rs1293320108 3997 dbSNP
rs1212656065 3998 dbSNP
rs1257561778 4010 dbSNP
rs1357839927 4011 dbSNP
rs1296752492 4013 dbSNP
rs8127303 4015 dbSNP
rs1381997653 4019 dbSNP
rs1385996068 4026 dbSNP
rs962804845 4031 dbSNP
rs1487702604 4032 dbSNP
rs1160488903 4036 dbSNP
rs1190900851 4038 dbSNP
rs142965563 4040 dbSNP
rs201948634 4043 dbSNP
rs4046827 4056 dbSNP
rs1476152492 4066 dbSNP
rs529847566 4070 dbSNP
rs1260915443 4072 dbSNP
rs1192753340 4074 dbSNP
rs565856598 4080 dbSNP
rs1447336016 4081 dbSNP
rs1263472890 4089 dbSNP
rs1424983400 4092 dbSNP
rs1355166071 4094 dbSNP
rs768912110 4098 dbSNP
rs2334610 4099 dbSNP
rs1273273773 4101 dbSNP
rs923943517 4102 dbSNP
rs1337659736 4103 dbSNP
rs1276855613 4110 dbSNP
rs1227215187 4111 dbSNP
rs1412978392 4134 dbSNP
rs4263203 4135 dbSNP
rs1376123991 4136 dbSNP
rs3999506 4138 dbSNP
rs367675423 4141 dbSNP
rs1393946467 4158 dbSNP
rs1326730471 4164 dbSNP
rs1463072284 4173 dbSNP
rs1296423482 4185 dbSNP
rs8130773 4189 dbSNP
rs1169846645 4195 dbSNP
rs935556454 4196 dbSNP
rs1374616562 4197 dbSNP
rs1196405326 4206 dbSNP
rs1450702817 4208 dbSNP
rs1253229341 4215 dbSNP
rs1328070310 4227 dbSNP
rs1456050541 4228 dbSNP
rs1256812533 4232 dbSNP
rs1195760558 4235 dbSNP
rs1272302433 4245 dbSNP
rs1231509694 4252 dbSNP
rs9967972 4253 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048188. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_ptb_knockdown ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uaGUUC---CA-GGCGACACUUGUgc 5'
            ||||    | |:|:||||||||  
Target 5' ucCAAGUCUUUGCUGUUGUGAACA-- 3'
11 - 34
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048188
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_ptb_knockdown
Location of target site ENST00000299443.5 | 3UTR | UUGGGUUGGUUCCAAGUCUUUGCUGUUGUGAACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.553 2.5e-3 0.537 3.4e-3 24 Click to see details
GSE21687 Ependynoma primary tumors -0.214 4.5e-2 -0.214 4.5e-2 64 Click to see details
GSE38226 Liver fibrosis -0.277 1.1e-1 -0.441 2.3e-2 21 Click to see details
GSE28260 Renal cortex and medulla 0.226 2.3e-1 0.280 1.8e-1 13 Click to see details
GSE19350 CNS germ cell tumors -0.208 2.6e-1 0.021 4.7e-1 12 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.152 2.6e-1 0.089 3.5e-1 20 Click to see details
GSE26953 Aortic valvular endothelial cells 0.078 3.6e-1 -0.077 3.6e-1 24 Click to see details
GSE32688 Pancreatic cancer 0.012 4.7e-1 -0.033 4.3e-1 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.008 4.8e-1 -0.108 3.0e-1 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.008 4.8e-1 -0.108 3.0e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
-0.008 4.8e-1 -0.108 3.0e-1 25 Click to see details
-0.008 4.8e-1 -0.108 3.0e-1 25 Click to see details
-0.008 4.8e-1 -0.108 3.0e-1 25 Click to see details
65 hsa-miR-124-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064177 KIAA1804 mitogen-activated protein kinase kinase kinase 21 2 2
MIRT069736 FOXG1 forkhead box G1 2 4
MIRT086429 NABP1 nucleic acid binding protein 1 2 6
MIRT105334 SLC7A2 solute carrier family 7 member 2 2 4
MIRT110455 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT172998 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT196428 TAOK1 TAO kinase 1 2 14
MIRT325704 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT365670 TSC22D3 TSC22 domain family member 3 2 4
MIRT365873 XIAP X-linked inhibitor of apoptosis 2 2
MIRT404126 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT404626 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT405284 ARF1 ADP ribosylation factor 1 2 2
MIRT406099 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT446627 SDC3 syndecan 3 2 2
MIRT446906 RGS5 regulator of G protein signaling 5 2 2
MIRT461790 FXR2 FMR1 autosomal homolog 2 2 2
MIRT463982 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT464204 VGLL4 vestigial like family member 4 2 2
MIRT472790 MTMR4 myotubularin related protein 4 2 4
MIRT473485 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT481124 AZIN1 antizyme inhibitor 1 2 4
MIRT485060 SUCO SUN domain containing ossification factor 2 2
MIRT487343 HLA-DRA major histocompatibility complex, class II, DR alpha 2 2
MIRT491948 VPS52 VPS52, GARP complex subunit 2 2
MIRT497208 CDH7 cadherin 7 2 2
MIRT497476 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT528203 NELFE negative elongation factor complex member E 2 2
MIRT529255 TRIM4 tripartite motif containing 4 2 4
MIRT530096 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530597 C7orf33 chromosome 7 open reading frame 33 2 4
MIRT534980 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT538326 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2 2
MIRT561237 ZNF652 zinc finger protein 652 2 2
MIRT562035 KRAS KRAS proto-oncogene, GTPase 2 2
MIRT563120 THAP5 THAP domain containing 5 2 2
MIRT563538 RBM41 RNA binding motif protein 41 2 2
MIRT566037 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT566505 PAWR pro-apoptotic WT1 regulator 2 2
MIRT566745 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT566850 LRRC58 leucine rich repeat containing 58 2 2
MIRT568077 CELF2 CUGBP Elav-like family member 2 2 2
MIRT576826 Tgfbr3 transforming growth factor, beta receptor III 2 2
MIRT608870 NR2E1 nuclear receptor subfamily 2 group E member 1 2 4
MIRT611997 VAC14 Vac14, PIKFYVE complex component 2 2
MIRT614054 FAM89A family with sequence similarity 89 member A 2 2
MIRT618800 SPATA21 spermatogenesis associated 21 2 2
MIRT619389 RSPH3 radial spoke head 3 homolog 2 2
MIRT622282 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624026 EN2 engrailed homeobox 2 2 2
MIRT626000 MPEG1 macrophage expressed 1 2 2
MIRT641792 USP32 ubiquitin specific peptidase 32 2 2
MIRT651599 WDFY2 WD repeat and FYVE domain containing 2 2 2
MIRT659662 CDC73 cell division cycle 73 2 2
MIRT663010 KIAA1586 KIAA1586 2 2
MIRT663561 ASTN2 astrotactin 2 2 2
MIRT669312 C16orf72 chromosome 16 open reading frame 72 2 2
MIRT685216 POTED POTE ankyrin domain family member D 2 2
MIRT695757 ZNF117 zinc finger protein 117 2 2
MIRT697909 TXNRD1 thioredoxin reductase 1 2 2
MIRT707181 RPH3A rabphilin 3A 2 2
MIRT707214 TRIM13 tripartite motif containing 13 2 2
MIRT707478 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT719507 LMAN2L lectin, mannose binding 2 like 2 2
MIRT755814 PARP1 poly(ADP-ribose) polymerase 1 2 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-124 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) NULL 16078949 Microarray hepatocytes 23107762 2013 up-regulated
miR-124 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-124 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-124 Cocaine NULL 446220 Quantitative real-time PCR HEK293 cells or rat brain parts 19703567 2009 down-regulated
miR-124 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-124 Chaihu Shugan San NULL NULL Microarray hippocampus 23947143 2013 up-regualted
miR-124 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-124 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved resistant High Laryngeal Cancer cell line (Hep2)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (MGC803)
hsa-miR-124-5p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-124-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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