miRTarBase - #MIRT685990


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pre-miRNA Information
pre-miRNA hsa-mir-2909   
Genomic Coordinates chr17: 37033745 - 37033813
Description Homo sapiens miR-2909 stem-loop
Comment This miRNA was referred to as hmiR-che-1 in .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2909
Sequence 4| GUUAGGGCCAACAUCUCUUGG |24
Evidence Experimental
Experiments QPCR
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs187707102 7 dbSNP
rs1375183104 8 dbSNP
rs1174848003 11 dbSNP
rs576577155 21 dbSNP
Putative Targets

Gene Information
Gene Symbol NEK4   
Synonyms NRK2, STK2, pp12301
Description NIMA related kinase 4
Transcript NM_003157   
Expression
Putative miRNA Targets on NEK4
3'UTR of NEK4
(miRNA target sites are highlighted)		 
>NEK4|NM_003157|3'UTR
   1 GCATTTGTCCTAATCTGCTGCCAGAATTAAAGACCTATTTTTAGAGGATTTTGGCTTAAAAAGCAAGGGCAAACAGTCAT
  81 TTGGAAGCCACTCACCACTGTTTTATATCTCTTTTTTATATCTCTTTGGCGTTTCCCTACAGAAAAGAAATTGGACAGAA
 161 CAGAATAATATGAAGCAGGATCACAAAAGAAAAAAAACTTTGGCTTTCATATTCTCTTTGTGAGGACAAATCTGTTGTTT
 241 GTTTGATTACTGTTTACTGAGCCTTAATCCACCAAGTTTATATTTAGAATTTTATTTTTTTAAGGTACTAATTAACTTAA
 321 ACACAGAGCTATAAAATGCTGGATTGAAAATTTTATATTGTAATGTAGAGATAAAAGCAGTAGGAGAAACAAATGACATA
 401 ATATGTCGTCATAATTCCTGCTATTGTTAATAACCTTAAGGAGTAGTTGATAAATTATAAAATTTTAAAAAGTCAATTCA
 481 GTTCTAGAAATAGATTTAAAGAATATGAAGTTCTATCTAGTACTTGAGCAGCTGTATTTCTTTTCTACACATTGATGGAC
 561 TTTTAATATTTTATTCTCATTTAATATAAACCTCATCTAGGGTATATACAAATTAAAACTGAGACACATTGGCTTTGTAA
 641 ATCAGTATGTTTTTACATAATGGTTTTGTTAGATTTATTTTTCCATCAGTGAAAACATTTCTTAAACACAAATTTCATTT
 721 CCATTTAAGCAATTTGTAAGCAAAGTCCAGGTCCATTTAGTTTTTGGATATATTTAATGTTTGTCTCCTGAAGTTTGTCT
 801 TCATGTACTGTAAGATATTAGTTGTCTTTCCATGTTTTAAATGTATGATTATATAGCACATATTTTATTAGTTGTTTAAT
 881 AAGAGGTAATACCCATCTAGGAAAGAAATTTTATGAAGTTAAATACAAGTCTTGAATAGTACATTTTCACTTCTGTATTC
 961 GAGGGACTCTAAAAATAAATATTGCTCCAGAAATGTTTTCAGGTGTTTTTTTTTTGAGACAGAGTTTCACTCTGTCAGTC
1041 AGGCTGGAGTGCAGTGGCATGATCTCAACTCACTGCAACCTCCACTTCTGGGGCTCAAGTGGTATTCCTGCCTGAGCCTC
1121 CCTAGTAGCTGAGACCACAGGCGTGTGCCACCACACCTGGCTAGTTTTTGTATTTTTTGTAGAGACAGGGTTACACCACA
1201 TTGCCCAGGCTGATCTCAGAACTCCTGGGCTCAAGCAATCCACTCACCTCAGCCTCCCAAAGTGCCAGGATTACAGGAAT
1281 GAGCCACTGTGCCCAGCCCTGTTTTCAGTTTCTATAACTAAAAATATATCTATCTTTGAAAATTACACACACACACAAAT
1361 ACTCTAATGAAATGTTCCCTTTACAGCCACTTAACAATTTTTTTTTTTTTTTAAGACACAGTCTTGCTCTGTCACCCAGG
1441 CTGAAGTGCAGTGGCCCAATCTCAGATCACTGCAAGCTCCGCCTCCCAGGTTCACTCCATTCTCCTACCTCATCCTCTCG
1521 AGTAGCTGGGACTACAGTTGCCCGCCACCATGCCCGGCTAATTTTTTTGTATTTTTTTAGTAGAGACAGGGTTTCACCGT
1601 GTTAGCCAGGATGGTCTCAATCTCCTGACCTCGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGA
1681 GCCACCGCGCCCGGCACACTTAACAGATTTTTATTTAGAGTTTACTGTGTGCCAGGTTCTCTGCCAGGAGCTGGGGATAT
1761 AGTGGTGAATAAAACAATACTTCCTGCCCTTTTACAGTGCTCACAGCCTGGTTTCTGATAACTCTTATTTTCACTTTGAA
1841 GGGTTTGCTAGAACTCAACTTGCAAAACCATCAAGTCCCAATGCCCAGTTGGGAACAAATCTTTGGCAAACTTGGTATCC
1921 TTGAGCTATTCACCTTTCCGTGCATGTTTTGGAAATCCACATCGTTCTGGAGAGTCATCAGTTTTACTTAATTTTTCTAA
2001 TGTATTGGTATAAAGTAGGTATTTTATTAGAATTAAAGGAATCTCACCCATATCTTTTTTTTTTTTTTTTTTTTTTGAGA
2081 CAGGGTCTTGCTCTGTCACCCAGCCTGGAGTGCAGTGAGGTGATCATAGCTCACTGCAGCCTTGACCTCCTGGGCTTAAG
2161 TGATCCTCCCACCTCAGCCCCTCAAGTAGCTAGGACCACAGGCATGCACCACCACACCTGGCTAATTTTTAAAATTTTTT
2241 GTGGAGAGGAAGTCTGTGTTGCCCAGGCTGGTCTCAAACTGCATTCAAGCAGTCCTCCTGCATCGGCCTCTGAAAGTGCT
2321 GGGATTATAGGCATGAACCACCACACCTGACTTCCCCCATACTTTCTTATTAATTACCATACTGTATATTTTTATTTTGT
2401 TTAAACATCTTTTCTTCCCACTTTTATCGTTTTTACTTGAGTGCTTAATTCATCTTCCTAAATTAATTTAAAAACTCATC
2481 TTTAAGACTGTGAATTTTCTTCCGAATATACCTTTGGCCACAGTTCAGAGACTTTGATGTGTTACTCTTTTGGCATTGGT
2561 TCTAAAATGTCAATCATTCTTTTTTTTTTTTTTTTGAGATGGAGTCTTCTTGTTGCCCAGGCTGGAGTACAGTGGTGCGA
2641 TCTTGGCTCACTGCAGCCTACGCCTCCTGGGTTCAAGTTCCCCTCCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACA
2721 CACCACCATGCCTGGCTGATTTTCGTTATTTTTAGTAGAGATGGAGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCC
2801 TGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCTAAATGCTGGGATTACAGGCTTGAGGCACCATGCCTGGCCTAAAGTG
2881 TCAGTAATTCTGATTTCGGTTTTCTCTTTTAGAAGTTTTGATTTCCACAGACTTACAAAGCTAAGGAAGTTTTATGTCCT
2961 TGCTCTGGCTACACTGCAGTGTTACTGAATATCACCTGCACAACCTTTACTGCTTGCAGTTTTTTTTTTCCTGTTGCTTT
3041 GTACATGATCCGTTATTCAAATGGCCTTATAGGCATTCAATAAAGGTGAAATGTTAAATACAAAATCACTTGTCTATTAA
3121 ATTTTATTCAAGGTTCTATATAAGATCTGATAAATGGAACTTTGTGATGGAAATGTTTTATATGGTAGCCACTAGTCACA
3201 TATAGCTATTGAACCTTTGAATCATGGCTAGTTTTAGAGTTTTATATTTTAATTTTAATTAAATAGACGTGTCTAGTGGC
3281 ACCATATTGTACAATGCAGTTCTCATTCAATAAATCTTAAGTACTTAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gguucucuacAACCGGGAUUg 5'
                    || |:||||| 
Target 5' -------gcaTTTGTCCTAAt 3'
 1 - 14 131.00 -7.50
2 
miRNA  3' gguucucuACA----AC-CGGGAUUg 5'
                  |||    || |||:||| 
Target 5' ttgattacTGTTTACTGAGCCTTAAt 3'
 243 - 268 127.00 -7.50
3 
miRNA  3' gguucucuacAACCGGGAUUg 5'
                    ||||::|||| 
Target 5' tcttttggcaTTGGTTCTAAa 3'
 2546 - 2566 123.00 -10.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30492183 15 COSMIC
COSN30580716 38 COSMIC
COSN19569713 46 COSMIC
COSN30515446 109 COSMIC
COSN30500984 129 COSMIC
COSN30170475 147 COSMIC
COSN30108944 168 COSMIC
COSN31587794 195 COSMIC
COSN9721552 477 COSMIC
COSN30544417 594 COSMIC
COSN28646689 706 COSMIC
COSN31962068 727 COSMIC
COSN31589481 856 COSMIC
COSN28637135 883 COSMIC
COSN23467073 1293 COSMIC
COSN14917584 1517 COSMIC
COSN29371658 2309 COSMIC
COSN27751578 2539 COSMIC
COSN27141251 2852 COSMIC
COSN29560379 3019 COSMIC
rs11235 706 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs371886246 2 dbSNP
rs1266792132 3 dbSNP
rs990850853 10 dbSNP
rs777416618 11 dbSNP
rs758254168 18 dbSNP
rs1241758083 26 dbSNP
rs1294152618 27 dbSNP
rs1425272521 28 dbSNP
rs1364870127 29 dbSNP
rs747764051 32 dbSNP
rs959118902 38 dbSNP
rs1310680040 44 dbSNP
rs1160680897 70 dbSNP
rs1389766204 76 dbSNP
rs1460594882 76 dbSNP
rs1220442524 100 dbSNP
rs1396103138 100 dbSNP
rs1440974531 100 dbSNP
rs1018026672 109 dbSNP
rs1333940329 109 dbSNP
rs1008356740 112 dbSNP
rs890798670 113 dbSNP
rs1333882894 118 dbSNP
rs190258795 120 dbSNP
rs1005763032 123 dbSNP
rs988629638 128 dbSNP
rs1469911809 130 dbSNP
rs952838367 131 dbSNP
rs1249852988 144 dbSNP
rs1038190792 178 dbSNP
rs1375056682 179 dbSNP
rs1413240936 189 dbSNP
rs1475076286 190 dbSNP
rs548926734 190 dbSNP
rs937168226 194 dbSNP
rs927096151 198 dbSNP
rs994443811 198 dbSNP
rs1176503756 199 dbSNP
rs981553300 202 dbSNP
rs752327916 204 dbSNP
rs1393137004 212 dbSNP
rs548975874 216 dbSNP
rs1308547694 218 dbSNP
rs1354639624 220 dbSNP
rs751834909 220 dbSNP
rs950155810 229 dbSNP
rs1472865226 233 dbSNP
rs550302822 234 dbSNP
rs529164042 239 dbSNP
rs1208460488 240 dbSNP
rs1006814194 245 dbSNP
rs1337522203 246 dbSNP
rs1485175433 246 dbSNP
rs114513483 252 dbSNP
rs1211626573 259 dbSNP
rs1485571851 262 dbSNP
rs1314576942 266 dbSNP
rs1305640349 270 dbSNP
rs1259988559 275 dbSNP
rs989208107 287 dbSNP
rs1169306346 298 dbSNP
rs1228360161 316 dbSNP
rs1351634978 321 dbSNP
rs1463052677 328 dbSNP
rs77933071 328 dbSNP
rs1374809978 329 dbSNP
rs1412809722 338 dbSNP
rs1314510194 339 dbSNP
rs1379547043 340 dbSNP
rs532231579 344 dbSNP
rs1413257613 355 dbSNP
rs936535523 356 dbSNP
rs1295105779 360 dbSNP
rs1396893042 360 dbSNP
rs532859091 363 dbSNP
rs1230656951 364 dbSNP
rs923809539 365 dbSNP
rs532766711 368 dbSNP
rs1282916738 370 dbSNP
rs1185623323 372 dbSNP
rs1483775866 372 dbSNP
rs1259193669 384 dbSNP
rs564066631 401 dbSNP
rs1467667549 402 dbSNP
rs1188668757 404 dbSNP
rs1343560960 405 dbSNP
rs1158437682 407 dbSNP
rs376749262 408 dbSNP
rs377714357 411 dbSNP
rs964879885 412 dbSNP
rs1288550227 416 dbSNP
rs917791601 420 dbSNP
rs1298439911 423 dbSNP
rs990535311 427 dbSNP
rs1232816674 429 dbSNP
rs1474721631 429 dbSNP
rs1256464141 430 dbSNP
rs1215563858 434 dbSNP
rs1183194485 441 dbSNP
rs1486652427 444 dbSNP
rs959024051 444 dbSNP
rs1007993424 447 dbSNP
rs1259698274 448 dbSNP
rs1452013801 451 dbSNP
rs908985957 457 dbSNP
rs1195473186 465 dbSNP
rs1425743774 465 dbSNP
rs890840090 467 dbSNP
rs1025336255 472 dbSNP
rs1346684198 474 dbSNP
rs984526437 476 dbSNP
rs950420957 479 dbSNP
rs898457018 491 dbSNP
rs1438766309 492 dbSNP
rs1276651565 499 dbSNP
rs774751559 500 dbSNP
rs1038258191 512 dbSNP
rs937220661 515 dbSNP
rs1331660792 517 dbSNP
rs1025831650 521 dbSNP
rs1340206502 527 dbSNP
rs766723674 530 dbSNP
rs1398056017 532 dbSNP
rs1466779657 536 dbSNP
rs1223167382 543 dbSNP
rs965667127 544 dbSNP
rs1480275610 551 dbSNP
rs1175341323 567 dbSNP
rs1409976170 570 dbSNP
rs561746665 573 dbSNP
rs1472783283 576 dbSNP
rs1160234848 592 dbSNP
rs1417453223 594 dbSNP
rs1460029332 596 dbSNP
rs1360117072 597 dbSNP
rs1350477564 598 dbSNP
rs1020280757 607 dbSNP
rs1352763922 611 dbSNP
rs1435818096 615 dbSNP
rs763477014 622 dbSNP
rs913290281 631 dbSNP
rs1293017599 636 dbSNP
rs1332248797 637 dbSNP
rs1162638760 646 dbSNP
rs988869241 657 dbSNP
rs935982103 672 dbSNP
rs1306410060 675 dbSNP
rs1460753283 682 dbSNP
rs1368890257 683 dbSNP
rs1166636961 690 dbSNP
rs1426441727 693 dbSNP
rs925908041 697 dbSNP
rs11235 706 dbSNP
rs889769284 723 dbSNP
rs1483319630 727 dbSNP
rs1186987594 733 dbSNP
rs912076007 734 dbSNP
rs1032273563 745 dbSNP
rs1465823326 748 dbSNP
rs1000922142 753 dbSNP
rs902556205 755 dbSNP
rs1250477965 759 dbSNP
rs1168999353 762 dbSNP
rs1372976018 764 dbSNP
rs879214507 776 dbSNP
rs772913142 799 dbSNP
rs1312665787 804 dbSNP
rs1356233843 805 dbSNP
rs1353880745 806 dbSNP
rs1042230380 810 dbSNP
rs955173518 812 dbSNP
rs1360712205 814 dbSNP
rs1266461019 818 dbSNP
rs1212325174 824 dbSNP
rs1025812602 832 dbSNP
rs993843625 842 dbSNP
rs962356621 843 dbSNP
rs1247435317 846 dbSNP
rs1278003214 848 dbSNP
rs1016531686 849 dbSNP
rs1238243500 850 dbSNP
rs1475187433 852 dbSNP
rs949233498 855 dbSNP
rs1392040990 859 dbSNP
rs1430961637 863 dbSNP
rs1297064398 867 dbSNP
rs1173559797 870 dbSNP
rs1374088003 870 dbSNP
rs1001421654 878 dbSNP
rs905763987 879 dbSNP
rs185330076 885 dbSNP
rs1367389067 893 dbSNP
rs1323932198 895 dbSNP
rs1299179059 909 dbSNP
rs150985010 928 dbSNP
rs896441797 931 dbSNP
rs1346904258 960 dbSNP
rs1055028835 961 dbSNP
rs937690451 970 dbSNP
rs1446654028 971 dbSNP
rs1250055941 976 dbSNP
rs1391363165 976 dbSNP
rs908892064 982 dbSNP
rs1193614113 987 dbSNP
rs1376465154 991 dbSNP
rs1479261583 999 dbSNP
rs540234384 1000 dbSNP
rs1173539682 1011 dbSNP
rs1322119195 1016 dbSNP
rs1388791951 1016 dbSNP
rs1455375164 1016 dbSNP
rs891915740 1016 dbSNP
rs1439474806 1018 dbSNP
rs1053617951 1022 dbSNP
rs1339857699 1022 dbSNP
rs1233813776 1027 dbSNP
rs984433644 1030 dbSNP
rs1278746734 1034 dbSNP
rs1460227999 1037 dbSNP
rs1226857416 1040 dbSNP
rs1372171417 1043 dbSNP
rs764733619 1043 dbSNP
rs929074680 1046 dbSNP
rs540877754 1050 dbSNP
rs925960382 1054 dbSNP
rs1265285783 1057 dbSNP
rs943629052 1061 dbSNP
rs1450911351 1064 dbSNP
rs1363640537 1071 dbSNP
rs1392775280 1078 dbSNP
rs972962048 1080 dbSNP
rs1160972338 1084 dbSNP
rs13084074 1088 dbSNP
rs1412291821 1092 dbSNP
rs1460552666 1096 dbSNP
rs1451603843 1101 dbSNP
rs1387351551 1102 dbSNP
rs965928186 1114 dbSNP
rs1328087905 1116 dbSNP
rs1333815513 1123 dbSNP
rs1019891796 1133 dbSNP
rs985687546 1134 dbSNP
rs1411394924 1138 dbSNP
rs954269202 1139 dbSNP
rs950939932 1140 dbSNP
rs919393763 1142 dbSNP
rs769784642 1143 dbSNP
rs1232830040 1144 dbSNP
rs972475284 1155 dbSNP
rs1000786301 1159 dbSNP
rs962408590 1161 dbSNP
rs902630632 1163 dbSNP
rs1021454918 1182 dbSNP
rs571920011 1186 dbSNP
rs758990085 1189 dbSNP
rs1013443226 1190 dbSNP
rs1184820386 1194 dbSNP
rs896296825 1202 dbSNP
rs1225161068 1220 dbSNP
rs748218948 1230 dbSNP
rs1229461047 1235 dbSNP
rs578128931 1236 dbSNP
rs776405042 1238 dbSNP
rs1301431659 1241 dbSNP
rs1024632289 1249 dbSNP
rs1232542605 1250 dbSNP
rs937930964 1251 dbSNP
rs1457950953 1259 dbSNP
rs887656292 1261 dbSNP
rs1048768722 1264 dbSNP
rs1431487354 1275 dbSNP
rs557917366 1277 dbSNP
rs1354575765 1280 dbSNP
rs928958650 1292 dbSNP
rs919055028 1299 dbSNP
rs1395724044 1300 dbSNP
rs149305355 1301 dbSNP
rs1014135691 1309 dbSNP
rs746861733 1314 dbSNP
rs1245650166 1317 dbSNP
rs1303257590 1318 dbSNP
rs538356188 1326 dbSNP
rs1040512009 1331 dbSNP
rs1275886690 1332 dbSNP
rs13079063 1333 dbSNP
rs767287019 1336 dbSNP
rs1000296187 1338 dbSNP
rs904596650 1339 dbSNP
rs912747566 1354 dbSNP
rs61220667 1357 dbSNP
rs1478035494 1358 dbSNP
rs943349158 1358 dbSNP
rs1451324986 1362 dbSNP
rs535342040 1362 dbSNP
rs748099852 1365 dbSNP
rs954301365 1366 dbSNP
rs1378739810 1377 dbSNP
rs747231437 1384 dbSNP
rs1464326611 1398 dbSNP
rs1304326239 1399 dbSNP
rs1404644795 1400 dbSNP
rs925530479 1407 dbSNP
rs1052449545 1411 dbSNP
rs111869354 1412 dbSNP
rs1296977576 1413 dbSNP
rs1298963527 1413 dbSNP
rs1363114754 1413 dbSNP
rs56359883 1413 dbSNP
rs572795681 1413 dbSNP
rs78751886 1413 dbSNP
rs796847781 1413 dbSNP
rs113171818 1415 dbSNP
rs1312020846 1428 dbSNP
rs1258085815 1431 dbSNP
rs764081243 1431 dbSNP
rs979440668 1457 dbSNP
rs1483375297 1458 dbSNP
rs1204182235 1462 dbSNP
rs919431818 1465 dbSNP
rs143529536 1469 dbSNP
rs1206314687 1475 dbSNP
rs1394433699 1478 dbSNP
rs1431317688 1480 dbSNP
rs1021068066 1481 dbSNP
rs879441880 1484 dbSNP
rs1278394704 1488 dbSNP
rs1466807158 1506 dbSNP
rs960800266 1509 dbSNP
rs1033516467 1510 dbSNP
rs1386612076 1518 dbSNP
rs1199968052 1519 dbSNP
rs1002005160 1520 dbSNP
rs1321256126 1520 dbSNP
rs1345761856 1526 dbSNP
rs887729946 1528 dbSNP
rs1313133740 1536 dbSNP
rs1227452485 1543 dbSNP
rs1236852878 1543 dbSNP
rs1465941271 1544 dbSNP
rs546379825 1553 dbSNP
rs993204471 1555 dbSNP
rs1288821881 1556 dbSNP
rs909630942 1559 dbSNP
rs532923178 1560 dbSNP
rs970134402 1561 dbSNP
rs1023937532 1562 dbSNP
rs1410075685 1563 dbSNP
rs11428497 1569 dbSNP
rs1458973173 1569 dbSNP
rs1435021445 1575 dbSNP
rs993174691 1576 dbSNP
rs1353191595 1579 dbSNP
rs1409631686 1582 dbSNP
rs955955778 1586 dbSNP
rs897495271 1591 dbSNP
rs181452063 1595 dbSNP
rs188864609 1598 dbSNP
rs1414572087 1599 dbSNP
rs1403764865 1604 dbSNP
rs1223743843 1606 dbSNP
rs1265931731 1607 dbSNP
rs944454385 1613 dbSNP
rs1456182932 1614 dbSNP
rs1253634646 1618 dbSNP
rs1473733239 1623 dbSNP
rs910266414 1632 dbSNP
rs1183145856 1633 dbSNP
rs1049917751 1634 dbSNP
rs1403644700 1639 dbSNP
rs1166948485 1640 dbSNP
rs1411790820 1643 dbSNP
rs148874395 1644 dbSNP
rs1410119336 1648 dbSNP
rs530646738 1649 dbSNP
rs1376395270 1650 dbSNP
rs1017694632 1657 dbSNP
rs1007609075 1660 dbSNP
rs1341385416 1671 dbSNP
rs1255712577 1679 dbSNP
rs1202855735 1686 dbSNP
rs561514689 1687 dbSNP
rs1443193610 1688 dbSNP
rs1280896773 1689 dbSNP
rs966959068 1690 dbSNP
rs541878485 1692 dbSNP
rs992133632 1693 dbSNP
rs960791161 1699 dbSNP
rs890470814 1701 dbSNP
rs1372850057 1704 dbSNP
rs1328395192 1710 dbSNP
rs1333879394 1712 dbSNP
rs184140710 1724 dbSNP
rs1363811099 1726 dbSNP
rs1226152379 1728 dbSNP
rs1002078693 1730 dbSNP
rs560808892 1739 dbSNP
rs557577129 1740 dbSNP
rs1342735480 1743 dbSNP
rs540928858 1760 dbSNP
rs1218448566 1762 dbSNP
rs1276166516 1764 dbSNP
rs1332353499 1766 dbSNP
rs1440912633 1769 dbSNP
rs1212503633 1771 dbSNP
rs1243889988 1775 dbSNP
rs1283347700 1792 dbSNP
rs1187275669 1793 dbSNP
rs1027458603 1796 dbSNP
rs879346538 1801 dbSNP
rs1037871530 1808 dbSNP
rs897700570 1818 dbSNP
rs1315623157 1821 dbSNP
rs1415886569 1826 dbSNP
rs1334375980 1838 dbSNP
rs1387326097 1842 dbSNP
rs1040450429 1847 dbSNP
rs1433642863 1850 dbSNP
rs1365852602 1853 dbSNP
rs1008554386 1858 dbSNP
rs1388581809 1863 dbSNP
rs1346840216 1864 dbSNP
rs888903803 1870 dbSNP
rs1050115700 1872 dbSNP
rs1459257878 1873 dbSNP
rs932850055 1873 dbSNP
rs778893338 1874 dbSNP
rs1163028453 1878 dbSNP
rs1473287620 1879 dbSNP
rs1043877936 1888 dbSNP
rs1239360860 1889 dbSNP
rs945623419 1896 dbSNP
rs914124950 1902 dbSNP
rs376313095 1909 dbSNP
rs948476424 1915 dbSNP
rs1245392089 1923 dbSNP
rs916916404 1927 dbSNP
rs992603706 1934 dbSNP
rs34182518 1939 dbSNP
rs956176522 1940 dbSNP
rs145786184 1946 dbSNP
rs544361662 1963 dbSNP
rs978625949 1964 dbSNP
rs952083696 1968 dbSNP
rs575721437 1972 dbSNP
rs1228611989 1979 dbSNP
rs144705449 1980 dbSNP
rs1350117074 1981 dbSNP
rs1267999144 1984 dbSNP
rs191561499 1986 dbSNP
rs1351480205 2001 dbSNP
rs1209810079 2002 dbSNP
rs1288384323 2004 dbSNP
rs1453783933 2005 dbSNP
rs1200616895 2019 dbSNP
rs1251456067 2021 dbSNP
rs1008069372 2022 dbSNP
rs1183878879 2034 dbSNP
rs1363924045 2039 dbSNP
rs976075642 2046 dbSNP
rs1160912077 2047 dbSNP
rs962303279 2049 dbSNP
rs1018859821 2050 dbSNP
rs1008540224 2052 dbSNP
rs1030770142 2052 dbSNP
rs185437411 2054 dbSNP
rs1244186046 2055 dbSNP
rs1348642834 2055 dbSNP
rs1282441572 2057 dbSNP
rs993508897 2061 dbSNP
rs1323316204 2063 dbSNP
rs1274441090 2072 dbSNP
rs1167871544 2077 dbSNP
rs1184800071 2077 dbSNP
rs1206904804 2077 dbSNP
rs1369624317 2077 dbSNP
rs1386470104 2077 dbSNP
rs1422834086 2077 dbSNP
rs1445235755 2077 dbSNP
rs1482263964 2077 dbSNP
rs372472872 2077 dbSNP
rs374943793 2077 dbSNP
rs1247406252 2078 dbSNP
rs1420233649 2078 dbSNP
rs1238030524 2079 dbSNP
rs1297468527 2085 dbSNP
rs1028586875 2091 dbSNP
rs999920460 2092 dbSNP
rs1340612360 2101 dbSNP
rs1406261233 2102 dbSNP
rs1416256016 2108 dbSNP
rs898114901 2112 dbSNP
rs36069882 2116 dbSNP
rs904243230 2119 dbSNP
rs1482729274 2126 dbSNP
rs1198368408 2128 dbSNP
rs566535170 2128 dbSNP
rs552803627 2137 dbSNP
rs1461360872 2138 dbSNP
rs539743431 2139 dbSNP
rs1190575657 2143 dbSNP
rs1045209601 2147 dbSNP
rs1451190649 2154 dbSNP
rs948505877 2155 dbSNP
rs1376847925 2173 dbSNP
rs745927301 2178 dbSNP
rs1465779029 2180 dbSNP
rs1171012059 2181 dbSNP
rs1487501156 2182 dbSNP
rs916989356 2194 dbSNP
rs1453515544 2196 dbSNP
rs1319919005 2201 dbSNP
rs1363666721 2205 dbSNP
rs1384356825 2209 dbSNP
rs373092273 2211 dbSNP
rs1245999940 2214 dbSNP
rs1311962575 2216 dbSNP
rs1230670725 2218 dbSNP
rs1264586859 2219 dbSNP
rs1323739126 2224 dbSNP
rs1057241940 2230 dbSNP
rs1245593913 2236 dbSNP
rs1222063360 2241 dbSNP
rs934307410 2249 dbSNP
rs1187018994 2252 dbSNP
rs1044296505 2254 dbSNP
rs187779700 2256 dbSNP
rs1431197985 2258 dbSNP
rs1177915321 2259 dbSNP
rs1272176539 2260 dbSNP
rs184195635 2271 dbSNP
rs1431750312 2277 dbSNP
rs1470393711 2296 dbSNP
rs968593977 2300 dbSNP
rs978678171 2300 dbSNP
rs770949005 2302 dbSNP
rs892732264 2304 dbSNP
rs1385484898 2305 dbSNP
rs1285519120 2306 dbSNP
rs985962607 2313 dbSNP
rs954998524 2321 dbSNP
rs781512384 2322 dbSNP
rs749207457 2328 dbSNP
rs1056713281 2340 dbSNP
rs1183665389 2345 dbSNP
rs939365720 2346 dbSNP
rs1264823773 2347 dbSNP
rs1487438245 2359 dbSNP
rs569548556 2369 dbSNP
rs777730627 2369 dbSNP
rs1269257436 2370 dbSNP
rs1480927306 2374 dbSNP
rs926615038 2376 dbSNP
rs1420925921 2377 dbSNP
rs760890449 2377 dbSNP
rs755586822 2378 dbSNP
rs35418959 2385 dbSNP
rs1371392003 2386 dbSNP
rs530503575 2388 dbSNP
rs1366568994 2394 dbSNP
rs1408887968 2394 dbSNP
rs1375012101 2399 dbSNP
rs1431465309 2399 dbSNP
rs193267983 2400 dbSNP
rs6445534 2409 dbSNP
rs895590238 2412 dbSNP
rs1319862563 2417 dbSNP
rs1478956711 2424 dbSNP
rs1056891562 2428 dbSNP
rs1181184745 2430 dbSNP
rs1231427178 2436 dbSNP
rs1471254337 2436 dbSNP
rs920679113 2440 dbSNP
rs1413159559 2442 dbSNP
rs1422642432 2445 dbSNP
rs924286137 2461 dbSNP
rs972332290 2462 dbSNP
rs961902600 2475 dbSNP
rs1429543532 2478 dbSNP
rs1306504859 2481 dbSNP
rs1276259944 2488 dbSNP
rs1019314621 2490 dbSNP
rs772475918 2493 dbSNP
rs1376332699 2498 dbSNP
rs1248144416 2500 dbSNP
rs1315609036 2503 dbSNP
rs115738369 2504 dbSNP
rs953257803 2514 dbSNP
rs188608431 2534 dbSNP
rs1220360074 2535 dbSNP
rs986401673 2538 dbSNP
rs1205470539 2544 dbSNP
rs954575178 2567 dbSNP
rs1286914120 2573 dbSNP
rs1409521259 2576 dbSNP
rs1351365503 2577 dbSNP
rs190815631 2579 dbSNP
rs1167106902 2580 dbSNP
rs1422094258 2581 dbSNP
rs1410244672 2582 dbSNP
rs1464708263 2583 dbSNP
rs77110483 2594 dbSNP
rs1358708748 2595 dbSNP
rs1174894434 2596 dbSNP
rs1364393928 2596 dbSNP
rs1438122016 2596 dbSNP
rs200752443 2596 dbSNP
rs1176865314 2597 dbSNP
rs1432802458 2597 dbSNP
rs1019546753 2603 dbSNP
rs1271770718 2609 dbSNP
rs923055471 2612 dbSNP
rs985352459 2612 dbSNP
rs1215417418 2619 dbSNP
rs1278226133 2622 dbSNP
rs972190450 2627 dbSNP
rs1416171698 2631 dbSNP
rs999787948 2635 dbSNP
rs1464896699 2637 dbSNP
rs904298739 2638 dbSNP
rs1244242839 2639 dbSNP
rs140728965 2646 dbSNP
rs1190939796 2654 dbSNP
rs766777116 2657 dbSNP
rs533712469 2660 dbSNP
rs1472767658 2661 dbSNP
rs537018707 2662 dbSNP
rs1056998087 2666 dbSNP
rs1455618562 2675 dbSNP
rs1320167021 2689 dbSNP
rs1326911758 2696 dbSNP
rs750924336 2697 dbSNP
rs1482709813 2701 dbSNP
rs1003818563 2704 dbSNP
rs1272800113 2707 dbSNP
rs1143225 2711 dbSNP
rs1016249731 2712 dbSNP
rs1225580473 2713 dbSNP
rs1263896255 2717 dbSNP
rs953873475 2719 dbSNP
rs1328548200 2723 dbSNP
rs905417958 2729 dbSNP
rs1237604570 2730 dbSNP
rs564500415 2731 dbSNP
rs1045121035 2734 dbSNP
rs930614758 2735 dbSNP
rs1221317354 2737 dbSNP
rs920716816 2738 dbSNP
rs1036441284 2739 dbSNP
rs544835885 2745 dbSNP
rs940737949 2748 dbSNP
rs1014221079 2749 dbSNP
rs1404627146 2752 dbSNP
rs911731861 2755 dbSNP
rs1143223 2762 dbSNP
rs565498727 2765 dbSNP
rs1330295512 2775 dbSNP
rs1407048736 2781 dbSNP
rs1284126553 2783 dbSNP
rs765707571 2794 dbSNP
rs575639608 2800 dbSNP
rs1237006435 2803 dbSNP
rs561804748 2804 dbSNP
rs1352041715 2815 dbSNP
rs1228237376 2817 dbSNP
rs1378716687 2821 dbSNP
rs1490933007 2831 dbSNP
rs1042781711 2832 dbSNP
rs947026573 2867 dbSNP
rs1435655892 2870 dbSNP
rs1183358079 2872 dbSNP
rs1363868918 2877 dbSNP
rs888744282 2888 dbSNP
rs1050366683 2897 dbSNP
rs1386905329 2898 dbSNP
rs1425102166 2899 dbSNP
rs146869954 2912 dbSNP
rs753218130 2919 dbSNP
rs923140161 2935 dbSNP
rs1331053348 2936 dbSNP
rs971859913 2936 dbSNP
rs541924513 2949 dbSNP
rs921838518 2950 dbSNP
rs978420187 2953 dbSNP
rs940805376 2960 dbSNP
rs968408360 2961 dbSNP
rs1413967717 2967 dbSNP
rs1274283250 2977 dbSNP
rs1162412256 2989 dbSNP
rs909300138 2989 dbSNP
rs1020485394 2995 dbSNP
rs1441304487 3009 dbSNP
rs1413980226 3018 dbSNP
rs969424767 3019 dbSNP
rs1244921779 3027 dbSNP
rs1463133224 3028 dbSNP
rs1024019029 3030 dbSNP
rs1445109256 3030 dbSNP
rs554482248 3030 dbSNP
rs1246850518 3031 dbSNP
rs1208710182 3033 dbSNP
rs1465736329 3036 dbSNP
rs1262936328 3037 dbSNP
rs1009993725 3042 dbSNP
rs572873588 3044 dbSNP
rs1169837540 3049 dbSNP
rs960017071 3051 dbSNP
rs375592442 3052 dbSNP
rs1003702405 3062 dbSNP
rs73839167 3068 dbSNP
rs1385624308 3070 dbSNP
rs539337636 3077 dbSNP
rs776838387 3080 dbSNP
rs768827617 3082 dbSNP
rs1325028122 3085 dbSNP
rs1229207922 3086 dbSNP
rs995281868 3095 dbSNP
rs899172807 3097 dbSNP
rs1343790731 3104 dbSNP
rs1036733148 3105 dbSNP
rs940804699 3106 dbSNP
rs1264393326 3107 dbSNP
rs1461767986 3129 dbSNP
rs765720837 3139 dbSNP
rs1187841923 3147 dbSNP
rs1259443911 3154 dbSNP
rs1021390169 3156 dbSNP
rs1193566760 3157 dbSNP
rs1373867507 3176 dbSNP
rs1462934321 3185 dbSNP
rs1469421921 3186 dbSNP
rs911935754 3203 dbSNP
rs1319946090 3206 dbSNP
rs1174450907 3207 dbSNP
rs1051574013 3208 dbSNP
rs1011290505 3209 dbSNP
rs752709745 3215 dbSNP
rs1390734192 3223 dbSNP
rs1288768422 3236 dbSNP
rs931797209 3238 dbSNP
rs12486554 3256 dbSNP
rs1384299619 3258 dbSNP
rs1296671661 3261 dbSNP
rs1050483452 3263 dbSNP
rs1457165920 3265 dbSNP
rs753256033 3268 dbSNP
rs933284426 3280 dbSNP
rs978639318 3282 dbSNP
rs147659930 3284 dbSNP
rs1323579873 3285 dbSNP
rs1341369327 3286 dbSNP
rs1207505436 3288 dbSNP
rs1036194497 3289 dbSNP
rs1447265260 3292 dbSNP
rs1486771705 3293 dbSNP
rs1205507214 3294 dbSNP
rs1266403732 3296 dbSNP
rs912897428 3302 dbSNP
rs1197508614 3310 dbSNP
rs1431593223 3312 dbSNP
rs988856818 3315 dbSNP
rs1480823575 3316 dbSNP
rs537295415 3320 dbSNP
rs1158416397 3332 dbSNP
rs1188636012 3334 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048188. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_ptb_knockdown ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
CLIP-seq Support 1 for dataset GSM1048188
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_ptb_knockdown
Location of target site ENST00000233027.5 | 3UTR | GAGUUUCACCAUGUUGGCCAGGCUGGUCUUGAACUCCUGACCUCAGGUGAUCUGCCUGCCUUGGCCUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
33 hsa-miR-2909 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254788 XRCC6 X-ray repair cross complementing 6 2 4
MIRT464426 UHMK1 U2AF homology motif kinase 1 2 2
MIRT478185 DDX6 DEAD-box helicase 6 2 6
MIRT481768 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT489915 RTKN rhotekin 2 2
MIRT500566 VPS4A vacuolar protein sorting 4 homolog A 2 8
MIRT510700 SREK1IP1 SREK1 interacting protein 1 2 6
MIRT513331 CDK2 cyclin dependent kinase 2 2 4
MIRT524310 CTC1 CST telomere replication complex component 1 2 4
MIRT533571 TOMM40L translocase of outer mitochondrial membrane 40 like 2 2
MIRT537784 EIF4E3 eukaryotic translation initiation factor 4E family member 3 2 2
MIRT540489 ZMAT4 zinc finger matrin-type 4 2 8
MIRT547020 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT549561 C19orf12 chromosome 19 open reading frame 12 2 2
MIRT557346 HBP1 HMG-box transcription factor 1 2 4
MIRT564692 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT570167 LIPG lipase G, endothelial type 2 2
MIRT621677 UBE2QL1 ubiquitin conjugating enzyme E2 Q family like 1 2 2
MIRT629121 APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 2 4
MIRT633745 MCM9 minichromosome maintenance 9 homologous recombination repair factor 2 2
MIRT634178 TXNDC16 thioredoxin domain containing 16 2 2
MIRT646387 SLC22A6 solute carrier family 22 member 6 2 2
MIRT651181 ZNF281 zinc finger protein 281 2 2
MIRT651892 UFD1L ubiquitin recognition factor in ER associated degradation 1 2 2
MIRT675180 KIF1C kinesin family member 1C 2 2
MIRT682670 CPM carboxypeptidase M 2 2
MIRT685990 NEK4 NIMA related kinase 4 2 2
MIRT698850 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT699396 SLC2A1 solute carrier family 2 member 1 2 2
MIRT723260 SREK1 splicing regulatory glutamic acid and lysine rich protein 1 2 2
MIRT725320 NFASC neurofascin 2 2
MIRT734596 CD276 CD276 molecule 2 0
MIRT734938 PTEN phosphatase and tensin homolog 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-2909 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2909 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)

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